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<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S4D2</accession>
    <name>A0A1H5S4D2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_10175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="SEF45459"/>
        <property type="gene ID" value="SAMN04489712_10175"/>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
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        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="10">
        <location>
            <begin position="26"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF45459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="562" mass="62208" checksum="979336692141826D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S4N0</accession>
    <name>A0A1H5S4N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">STE24 endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_10178</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45569">
        <property type="protein sequence ID" value="SEF45569"/>
        <property type="gene ID" value="SAMN04489712_10178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
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    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
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            <end position="32"/>
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        </location>
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    </feature>
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            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
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        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF45569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="442" mass="47347" checksum="241403C5E78927C7" modified="2017-01-18" version="1">MSGLGRARTAALVTAAGLFVAVGVVLLTTTPWDPLPGAVPGGAVPPDPARDFSPAELARSAAFDAAINPPAYAGLAAGLAVALALGLTPLGARFIGWCTARVPRRTPRLVVAVIAMTTLLWAAGLPFGVWRENALRRYGLSVQTWPGWAVDELKSLGLSWAVWTVAVLLLFALARRFPRYWWTGAAAGGFALVVAISFVYPLVVEPVFNRFSPLPAGPLRSDLLAMADRDGVPVENVLVADASRRTTSLNAYVSGFGSTRRIVVYDTLLESSPARIKSIVAHELGHAKRNDVLYGTLVGALGTSGAVCLLFLALTSPRLRRRAGLRDGDGAPDEREAAADPRSVALLLAAVVVLTQLGGPVQNLVSRRIEARADAHALDLTRDPVTFVSMQHELSVRNLSDLRPDSLEYVLWFSHPGAPERIAMARDWARLHRIPEPPSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S831</accession>
    <name>A0A1H5S831_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_10191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45967">
        <property type="protein sequence ID" value="SEF45967"/>
        <property type="gene ID" value="SAMN04489712_10191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="9">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF45967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="24219" checksum="393F4CC2B72A6017" modified="2017-01-18" version="1">MLPVATASAIQATPHARTNRPNLVSVGTIVWLSSELMFFAALFAMFFTIRSVIIGQEGHHAWPGAELDLPLSAFNTTILVLSSVTCQMGVFKAEAGKVGRDGGLLNVKRWGLREWYVLTFLMGAYFVAGQCFEYYNLVTKDGLTLSSSPYGSVFYLTTGFHGLHVTGGLIAFLFVLGRTYAAKRWTHEQATSAIVVSYYWHFVDVVWIGLFGVIYLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SA55</accession>
    <name>A0A1H5SA55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="9" type="ORF">SAMN04489712_101132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47469">
        <property type="protein sequence ID" value="SEF47469"/>
        <property type="gene ID" value="SAMN04489712_101132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="24"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF47469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="30175" checksum="23A5F497BDE26A17" modified="2017-01-18" version="1">MSTVHSPVGGHVPVAGGLATGGLKYAEQIGAEAIQVFVSNPRGWAQAAGRPEEDARLRDSGVPVFVHANYLINPGSPNAETLEKSLASIRHALQRGHAIGAGGVVIHTGSSVTWSYEEAMRQVHEHLLPVVAEIPEDGPQLLLEPMAGQANMLCATVQQLGPYFEALEHHPKVGVCLDTCHAWAAGHDLTASGGVKATVDALVEAVGPDRLKLIHANDSKDPCGSGRDRHENIGAGAIGEAPFADLFRHPAVAGVPFIIETPGRAPEPHRKDVETLKRLRDNLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SRN5</accession>
    <name>A0A1H5SRN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53219">
        <property type="protein sequence ID" value="SEF53219"/>
        <property type="gene ID" value="SAMN04489712_101335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="85"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF53219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="260" mass="27768" checksum="65F5F2D15362A546" modified="2017-01-18" version="1">MSKATRHRNARERLAEERRRQEQRGRRLRAVLVSGGAVLVIGIVVAAVVLMRSGGDDGEATATAPLTRQADGSVVMAQPGVSGPVLEIYEDFQCPACQKFEEATGKTIKELAAEGKVKVVYRPFSLFREWPEPTKGNSARALNASLCAPADKWIAYHDRLFAEQGPENSKGFENDDLVGWAKEVGITGAAFEGCVRGAEKEPMIAQANAAATKAGVQSTPWVTLNGRKLDQNEAFTAAGLRKAVENAPDTATTSPATSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SVJ8</accession>
    <name>A0A1H5SVJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="13" type="ORF">SAMN04489712_101383</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54623">
        <property type="protein sequence ID" value="SEF54623"/>
        <property type="gene ID" value="SAMN04489712_101383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="107"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEF54623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="31821" checksum="8D580CE8F71D0546" modified="2017-01-18" version="1">MRRYLAHLAADRGLAANTLSSYRRDLRRYAQALAARGRRAVGEVTEGDVRGYLAGLGEGDATHPPLSARSAARAVAAVRGLHRFAVREGLAAADPAAGVRPPASPRPVPRAISVAEVERLLAAAPGDTPRGLRDRALLELLYGSGARISEAVGLDVGDFDLTGGLIRVAGQGGRTRRVPVGEHARRAAEAYLARARPELARDGGAMPALFLNARGGRLSRQGAWMVLRATAERARLAGVSPHTLRHSFATHLLDGGADARVVQQLLGHAPATTALAPGRQACALVTEGLLQEVHATSHPRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TD55</accession>
    <name>A0A1H5TD55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60729">
        <property type="protein sequence ID" value="SEF60729"/>
        <property type="gene ID" value="SAMN04489712_101573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="FUS7/LUC3-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="17"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF60729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="468" mass="48959" checksum="8AB069E45EC4A0E0" modified="2017-01-18" version="1">MSDFTMTIAGAGVTAPQTFGVVNPATGAEHAQAPDCSPEQLEAAMSSAAEAFTEWRKDEQARRKALLAAADALFASAGDLAPVLTAEQGKSLQDATMEVMGTGVWLKYFAELELPREIVQDDANAFVEVVRRPMGVVAAIAPWNYPLLLAAWKLGPALLAGNTVVLKPSPYTPLATLKLGELLRGVLPPGVFNVISGGDALGAQMTAHPVPRKISFTGSVPTGKKVAAAAAPDLKRVTLELGGNDAAIVLEDADPAKVADRLFGAAFMNNGQVCSAIKRVYVPDALYGDMVEALAAKARSVKVGNGMDEGVEYGPIQNKPQFERVSELVADALSHGAKAAAGGKPIDGPGYFFQPTILADISDGTRIVDEEQFGPALPVVRYSDVEDAVARANGTPFGLGGSVWGTDLDRAAEVAGRLECGSAWVNTHLALAPNLPFGGFKWSGIGVENGPWGVYGFTEVQVVYRAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TSJ3</accession>
    <name>A0A1H5TSJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65852">
        <property type="protein sequence ID" value="SEF65852"/>
        <property type="gene ID" value="SAMN04489712_101733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF65852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="60" mass="6875" checksum="C42235F258A29C50" modified="2017-01-18" version="1">MTRIRDRWADRGNGLARFWLARLQAMPIAMAARFLHALARRTAERVADGVPDRTTGRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UUQ1</accession>
    <name>A0A1H5UUQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78795">
        <property type="protein sequence ID" value="SEF78795"/>
        <property type="gene ID" value="SAMN04489712_10238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF78795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="36" mass="4051" checksum="A2D6739B6343B982" modified="2017-01-18" version="1">MEITHAQESQDDARQEAAKALQDALDRRDNGGRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UVF1</accession>
    <name>A0A1H5UVF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_10244</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78934">
        <property type="protein sequence ID" value="SEF78934"/>
        <property type="gene ID" value="SAMN04489712_10244"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="196"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="395"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF78934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="581" mass="62130" checksum="553896F3D35E81B8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UZP7</accession>
    <name>A0A1H5UZP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system, NarL family, response regulator DesR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80585">
        <property type="protein sequence ID" value="SEF80585"/>
        <property type="gene ID" value="SAMN04489712_102105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF80585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="21160" checksum="663B1F658846350E" modified="2017-01-18" version="1">MIRVLIVEELSLLRGGLVALLEDHNDFAVVGAVDEAEKLVPTACEVHPDIALIGVEGAQADAFTLVRRLRDQLPDCAAVLMADRGRPGDLRRAAAAGAAGFVLKGTSPDTLTGGLRRVAAGERVIDADLAFAELAAADSPLTPRELEVLRLAGEGASAAQIADTLVLTIGTVRNHLSRINRKIGARNRVHAIRIAESAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VCG1</accession>
    <name>A0A1H5VCG1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SAMN04489712_102260</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84920">
        <property type="protein sequence ID" value="SEF84920"/>
        <property type="gene ID" value="SAMN04489712_102260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="14"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="351"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEF84920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1115" mass="121682" checksum="46020234DD25D7F2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VDT7</accession>
    <name>A0A1H5VDT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA carboxylase, carboxyltransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85413">
        <property type="protein sequence ID" value="SEF85413"/>
        <property type="gene ID" value="SAMN04489712_102279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="25"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="286"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF85413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="539" mass="57556" checksum="8FF4B535B30FF9CD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VJB9</accession>
    <name>A0A1H5VJB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86647">
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        <property type="gene ID" value="SAMN04489712_102323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="23"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
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    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF86647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15460" checksum="C7D516D8F9C8D9F5" modified="2017-01-18" version="1">MTRMTFASEHEQTVALIRPAADDRAPGKVREWAKETLARWGLPALADDLNTVLTELVTNAWQAGAGDLLVLLEPCQDRGLVDVAVWDDAPGVPVRREPDFVAESGRGLHLVEALTTAWGVEPDPGGGPGKTVWASLRVPGDGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VKD5</accession>
    <name>A0A1H5VKD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPFH domain / Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87663">
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        <property type="gene ID" value="SAMN04489712_102351"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="272"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF87663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="466" mass="52140" checksum="CDF21863832CBED1" modified="2017-01-18" version="1">MSAEKGNSYLEQVVAQQAVLEDDLRSRRPGAPPAPAWAGAPASAPAPGPLAKRERALGGARAEQAANAAIDVRISGFWRWKTVIVPPNAFVVHTRRGRAEPLHLGLGVSFRYNPATDSYLVVPGATQTILINAYCICRELQGVLVQGYVQWIIQDFATAYRKLDFSDHEDPMRLVNLQLREQAEAAIKDKVATMSVHDVLSDKQPIIEELTARLRAVAEGQNNSDQGLGLRIVTVQIKEAVVSSSRLWENLQKPFRSEQGKLARLAELQAEEVISEREMSAERLRETRRIEHARELEMLRARNDAERFDTESAERLRRTHREHDDRRQVEDLELETAIHSLELVRRRQAEQTETDRLRIEQEQRLKRLEQDGELALEASRAEAAHQRALLELEATRLRAAIDNERTPAAIQADLVSALPEIVQRLPRPNEMRNVTIGGADTSRLGGLLAELMGVLGALREDGGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VQE1</accession>
    <name>A0A1H5VQE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89522">
        <property type="protein sequence ID" value="SEF89522"/>
        <property type="gene ID" value="SAMN04489712_102417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF89522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12365" checksum="78E74C908E112B91" modified="2017-01-18" version="1">MIRTLVRRVARAGTGDGDGGRGAAVPLAMAARELAEGARRLPGVQGVRVRPAGTAARPRLAMTVVCAEEADLAALYTALEKGPADRCRSMTKMSDLPVTVRFKVVYRQSPTFPQTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W1Z5</accession>
    <name>A0A1H5W1Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93522">
        <property type="protein sequence ID" value="SEF93522"/>
        <property type="gene ID" value="SAMN04489712_102560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF93522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="234" mass="25439" checksum="C7CDDCBF7DFDFDBB" modified="2017-01-18" version="1">MTTTGEATGDATGGADRAPIRAVFFDIGETLINEGEIYGRWADWLGVPRHTFLTKLGALLATGGTHLDLLEYFRPGFDLDKEERRRAEAGVPNGFGAEDLYFDARRCLAGLRAQGLYVGVAGNQPVQAAEQFAALGLEADVVGISDVWGVSKPSPEFFARCAAECGLPPGDILYVGDRIDNDVRPALAFGMRAAFLRRGPWGHIQHDERALRRCTFVLDDLVDLPALVERHNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W7N0</accession>
    <name>A0A1H5W7N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_102619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95410">
        <property type="protein sequence ID" value="SEF95410"/>
        <property type="gene ID" value="SAMN04489712_102619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="142"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="254"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF95410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="410" mass="45064" checksum="A73D4663C4BC7DA0" modified="2017-01-18" version="1">MPFWKTDGMDFELSPKAQAYSAKLQEFMDQHVYPAEPIYAAQRAELIAAGTPHRHPPIIDELKTEARKRGLWNLFLPDISGLSNVDYATLAEITGRSLDLAPEAVNCAAPDTGNMEVLHMFGTPEQQERWLRPLLDGEIRSAFAMTEPAVASSDATNITTSIVRDGDEYVINGRKWFSSGAADERCKIFIVMGKTDPDGPTHRQQSQILVPRDTPGVRVVRDMTIFGYSDQHGHPEVVFEDVRVPAGNLIGQEGDGFAIAQARLGPGRIHHCMRAIGMAERALELMCRRAASRVAFGKPLAQQGVVQQQIAESRMAIEQARLLTLKTAWLIDRHGAKGARTEIAAIKVIAPRVAGEVIDRAIQVHGGAGVSGDTPLAAMYAWARAMRIFDGPDEVHVRTVARQELKSYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WAP3</accession>
    <name>A0A1H5WAP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein SpoIIM, required for sporulation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96534">
        <property type="protein sequence ID" value="SEF96534"/>
        <property type="gene ID" value="SAMN04489712_102649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF96534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="36199" checksum="94AD1462DE888054" modified="2017-01-18" version="1">MDVDAYVAAHHAEWSRLEWLINHSRRLDGAQIDELVELYQRAATHLSVVRSSSPDPVLVGRLSSLVARGRAAVAGAQAPLWRDTTRFLTRSFPAAAYRMRWWWLGVAVLGNLFSLVYAVWLVRNPEVQATLATPYEVRQLVEHDFANYYTEHSAQSFAFMVWVNNAWVSATALIFGILLGIPTLYVLFANQLNLAQVGGFMFAHGKGDVFFGLILPHGLLELTAVYLACAAGLKLGWTIIDPGPRTRGRALAEEGRATVAIALGLVLVLLVSGLIEGFVTGWVHLTWLRIGIGVVAELAFLAYVVALGRPAARQGETGDSDLRPDLAPTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WC50</accession>
    <name>A0A1H5WC50_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein SAMN04489712_102663</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97035">
        <property type="protein sequence ID" value="SEF97035"/>
        <property type="gene ID" value="SAMN04489712_102663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF97035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="58" mass="6339" checksum="A904C43B46063F8B" modified="2017-01-18" version="1">MKLDSWLLEILACPNCQGALRADESADELVCTGECGYAYPVRDDIPVLLVDEARTPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XLQ9</accession>
    <name>A0A1H5XLQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oleandomycin transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12415">
        <property type="protein sequence ID" value="SEG12415"/>
        <property type="gene ID" value="SAMN04489712_103302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG12415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="34924" checksum="BE168F871C3DC373" modified="2017-01-18" version="1">MTFAIEAEGLVKHFGETRALNGVDLTARTGSVLGVLGPNGAGKTTSVRVLATLIQPDEGQARVGGYDVVKDAHRVRQLIGLTGQYAGVDEMLTGTENLVLIGRLLGLRRAQARSRAAELLERFELTDARDRAAKTYSGGMRRRLDLAASLVGRPQILFLDEPTTGLDPRSRGGLWDIVRGLTDDGVTVLLTTQYLEEADQLADDIVVIDHGRVIARGTPDQLKTQAGGQMLEVRPVTAADHVTVARIVGELTGAQPEVRDGLVSAPLSDPAVMPAVVRRLDEAGVTVGELSLRKSSLDEVFFALTGHHAEEQQEAEDAQAESVKAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XR97</accession>
    <name>A0A1H5XR97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14309">
        <property type="protein sequence ID" value="SEG14309"/>
        <property type="gene ID" value="SAMN04489712_103375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289726" evidence="1">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG14309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="32883" checksum="321B34092F560710" modified="2017-01-18" version="1">MRSHRARRRSSGLAAVVALAATCSTTAGMTSPDPYAAPGALPALSAPALGARYASVRHDIDGALRTARQNGDGDRVRALSAFLAPGRRFLSFDARGRGRAVEVLGDLAAADRVAVVVPGADGSLTGYDSWKFAGGGARALYARARQVSPGTRLAVVAWLGYDSPRTLSTDVLTAGRATGAARGLRRLVSEVRRVNGAAGLSLLCHSYGSVVCAKAARHVHAQDIALFGSPGTGVARASDLRTGARVWAGRAGGDWITFVPHVRFFGVGFGADPVSPEFGARVFDAGSGRHSGYLKPGSTPLRNLALIALGRSQEVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XRP1</accession>
    <name>A0A1H5XRP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14090">
        <property type="protein sequence ID" value="SEG14090"/>
        <property type="gene ID" value="SAMN04489712_103366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG14090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="13473" checksum="544A0AFEB1D4691D" modified="2017-01-18" version="1">MATAQQTRAPRGRTAKTQAKTQAKTPARAQAKTPAAAEKERHGASVPIPVVTPRLKVLHVPVPGGGEGAGRLPPPERLAFYGGLGAMAAFNVISWPVAAAIGVGTAIAGRARRAGRAGDQPEAGAAKARTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XSL6</accession>
    <name>A0A1H5XSL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14789">
        <property type="protein sequence ID" value="SEG14789"/>
        <property type="gene ID" value="SAMN04489712_103393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="227"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG14789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="480" mass="50101" checksum="650FD0F7E3912947" modified="2017-01-18" version="1">MTVLDNRVVGPAPASPQEQTDPRHPRVRLEILFDDGTFRPLTEENDGSGVLAGVGRVEGLPVVAFASDPRVQGGAMGMAGCQAIVAAYDHAVRERLPIVGVWHSGGARLAEGVESLHAVGLVFAAMTRASGIVPQISVVLGAAAGGAAYGPALTDIVILAEQGKIFVTGPDVVKSVTGEEIDMAGLGGPEPHSRKSGVVHVVAKDDTDALARARTLAVLLGHQGRMRVDEVAERDFSGLLPDNVRRAYSVQPLVKGLVDNADESYVELHAKWAPNIVTALGRLGGRTVGVIANNPLRLGGCLDAQSAEKAARFVRMCDAFGVPLVVLVDVPGYLPGVGQEHGGVVRRGAKLLHAFAEATVPRVTLVTRKAYGGAYIAMNSRSLGATRVFAWPTAELAVMGAVAAVRVLHRRALAAVTEDERPALEAKLAAEHEQIAGGLERACELGVVDEVITPATTRTAIARAIAEAIPARGTHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XU58</accession>
    <name>A0A1H5XU58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (NDP forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15075">
        <property type="protein sequence ID" value="SEG15075"/>
        <property type="gene ID" value="SAMN04489712_103404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG15075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="823" mass="87643" checksum="9368F4C4DF87846B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZE4</accession>
    <name>A0A1H5XZE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17048">
        <property type="protein sequence ID" value="SEG17048"/>
        <property type="gene ID" value="SAMN04489712_103482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="414" mass="46378" checksum="744F5FA6F0824003" modified="2017-01-18" version="1">MVKAADINLTSWGFWERPLEERHAAFRALRYEPGLPHYEEPVTYLPPGPGYYALTRHADVVEASRRPKDFCSGQGAISIPDMPADLGEYFGSMINMDDPRHAHIRRIVSRAFSPRMIQRFEDHVEEVAARIVTGVREGGGTGDFVADVAARLPLTIICELMGISEDHYQTVLDATNVILAGADPEFVDAEDFEKIAMALLTAGQTLKDIVEDLGRHRRANPTDDLTSALVNANIDGESLTDQELGSFFILLVVAGNETTRNAIAHGLHLLTHNPDQRALLTEDFEARIPGAVEEIVRYASPVIWMRRTATCDTTLNEHEIKAGDKLLLYYWSANRDETVFDHPERFDITRSPNPHIGFGGPGPHFCLGAHLARREITVMFREMFRQVPNIRTAGEPDRLLSNFINGIKRLPYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YKS9</accession>
    <name>A0A1H5YKS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24759">
        <property type="protein sequence ID" value="SEG24759"/>
        <property type="gene ID" value="SAMN04489712_10471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG24759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="14969" checksum="33174779220ABD25" modified="2017-01-18" version="1">MNTTYTAEGHIDAHPQVVLSVAHGPGGAIATLQGDLDVATAPALREGLLALLRPGLRLLVLDLSRLWFCDAAGVSVLLGTRRRATLLHIPLRLAAPRSRVAKILEVTGADCGFMIYSTLPEALALPLPPTLGPDRHRALCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YLD6</accession>
    <name>A0A1H5YLD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24405">
        <property type="protein sequence ID" value="SEG24405"/>
        <property type="gene ID" value="SAMN04489712_10456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="126"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="478"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG24405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="875" mass="94633" checksum="7B7698375EF3F903" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YM23</accession>
    <name>A0A1H5YM23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25128">
        <property type="protein sequence ID" value="SEG25128"/>
        <property type="gene ID" value="SAMN04489712_10485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG25128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="179" mass="19826" checksum="C9CC22A5392E4974" modified="2017-01-18" version="1">MANSGLWVGVLTALTALGAGYLTSRATLRAALAQARTTTRAQALREQRERRRSSYREMMSCAHAFSAITWQIDDVDATHDREGKDRLLSQMYERIGPAIGDMNRAMHEVRLDGPDEVSAAADHLRNMARRVQVLLQALIGDGGPGRRDAYDAAYRDFREAYVTFIGLARGALEVKDEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YSQ9</accession>
    <name>A0A1H5YSQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26732">
        <property type="protein sequence ID" value="SEG26732"/>
        <property type="gene ID" value="SAMN04489712_104147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG26732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="507" mass="53725" checksum="6A30A3CB42B06A96" modified="2017-01-18" version="1">MTVPGSPLPKVLCEVEPGRWVQVASPYAEALEHKGPGCGLGDLGCMAKQAVNGWFQDLVTSAAKPVFGFLGATVLGTPEIDSGGMARARQLWGASQVIANTCFVLVVSIAGVLLMAGQSLPGQVSPKELLPRVVLAFGAVNLSLTFIGYGISFANGLAQAFLSSGPSKVDAGVVADTLGASIAATALTGGVFMPMVALAVIVLALVVTFIYIVRLAITMVLIAAAPLALMFHALPMTDGLARLWWRGITGILAIQVCQALALVTAFQLLFSEVTDSSGSVVGVPTRTDLTDLLVAIALLWVMIRIPSWVARTVWQPAQPRLLGQMLKTFVLYRGIGALMNKTGRSVPAGAGTKPDQGRHRPPSGKPTPRPTRPRRQPTRLQPTHEVVHRQPRPPTPPEPPEPRRPPQAAPPGWNVSADSDTGVAGRAVQLALPISVRPKPGTARPAQLALPIPVTRVPRPPAPPPVSQGRPRVRSRQLMLPGMPRRPVPPRQLALRLELPKQHGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZGD2</accession>
    <name>A0A1H5ZGD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone HtpG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_104533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35140">
        <property type="protein sequence ID" value="SEG35140"/>
        <property type="gene ID" value="SAMN04489712_104533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG35140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="589" mass="64583" checksum="CEA01758E45A0CC1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZGN4</accession>
    <name>A0A1H5ZGN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosaminyl deacetylase, LmbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34797">
        <property type="protein sequence ID" value="SEG34797"/>
        <property type="gene ID" value="SAMN04489712_104516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="26606" checksum="529770C412BAD557" modified="2017-01-18" version="1">MTDVIDDRDIERALVVMAHPDDVDFGSAGTVAVWTDRGIEVTYLMVTDGDAGGFDDGMTRQEMAALRREEQRAAAKAVGVTDVRFLGYPDGRVEATLELRRDIARVIRQVRPDRVLMPSPERNYERIHPSHPDHRAVGSAALDAVYPDARNPYAFPELREEGLEAWTVREVWLNGGPVADHYVDVTEVFGRKLTALRSHASQVAHVPDLEGMLRGWMGANARAAGLPEGHLAEGYHVVSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZIK1</accession>
    <name>A0A1H5ZIK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_104563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35834">
        <property type="protein sequence ID" value="SEG35834"/>
        <property type="gene ID" value="SAMN04489712_104563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="346"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG35834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="463" mass="48869" checksum="F658EA17A979F221" modified="2017-01-18" version="1">MVDMTRIVIIGGGPGGYEAALVAAQLGADVTVVEREGVGGACVLTDCVPSKTLIATSTRMAVLSESASLGVRFNGGPDGIVGGLEVDLGLVNKRVKDLARAQSFDISERLAYEDVRIVRGEARLTDPHTVTVNDTDLAADVVLIATGATPRVLPGAEPDGERILNWRQLYDLPELPEELIVVGSGVTGAELAGAYLSLGSKVTLVSSRDRILPTEDADAASVLQEVFLRRGMNVLSRSRAAGVRRSGDSVIVTLEDGRKVEGSHCLMTVGMEPNTRGIGLEKAGVQLSRGFVKVDKVSRTTVSNIYAAGDCTGVMMLASVAGMQGRIAMWHALGEAVQPLKLGWVAANIFTDPEVATVGVTQKMIDSGEVNARTVMLPLFSNPRAKMQGFEDGFVKLFCRPSTGIVLGGVIVAPRASELILGLSIAVQQHLTVDQVAHTFAVYPSLSGSITEASRRLMQESAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZU71</accession>
    <name>A0A1H5ZU71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucose/arabinose dehydrogenase, beta-propeller fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG39979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG39979">
        <property type="protein sequence ID" value="SEG39979"/>
        <property type="gene ID" value="SAMN04489712_1059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291948" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="526"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="4">
        <location>
            <begin position="723"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG39979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1022" mass="109626" checksum="30F358F01F658CCC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZJ4</accession>
    <name>A0A1H5ZZJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41908">
        <property type="protein sequence ID" value="SEG41908"/>
        <property type="gene ID" value="SAMN04489712_105106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG41908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="18407" checksum="3EAC9040C3B7264F" modified="2017-01-18" version="1">MAEVTAALIEEAMKKSALVWLTLPGLPQPRAAWHVWHDGAAYVLTGGEGEQPLPGLPEADRVPVTVRSKDKGGRLLSWVAACEHVEPGGDLWNEVAPLLAKERLNAPTHEGQLERWASESYVIRLVPTGEITEAPGGYDGDYATVRPVPTPATTAGTPPRLLGAKKRHADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A053</accession>
    <name>A0A1H6A053_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase carboxyl transferase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41415">
        <property type="protein sequence ID" value="SEG41415"/>
        <property type="gene ID" value="SAMN04489712_10578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="246"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG41415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="496" mass="51151" checksum="9FBB6E6208C52D33" modified="2017-01-18" version="1">MTRIGARELIDRILDAGSRTSWDAPPRPVAAPGSAYAAELAAARERSGCDEAVITGEGLLRGRRVAFVVSEFGFLAGSIGRATADRIVAAVERATAEGLPLLAAPSSGGTRMQEGTAAFVQMARITAAVMRHRAAGLPYTVYLRHPTTGGVLASWGSLGHVTAAEPGALIGFLGPRVYEALHGEPFPPGVQVAENLAAKGLVDAVVGIDDLPEVAARALAVLCAGDPPAVPPAPEPSGDVPGEVSAWESIERSRRPDRPGVRDLLRYGARDVTVLSGTGEGEAEPGLLLALARFGEAACVVVGQDRLSQRTGHPLGPAGLRVARRGMRLSRELGLPLLTVVDTPGAVLSAEAEERGLAGEIARCLAELTTLAVPTLCVLLGEGTGGAALALLPADRVLCARHGWLSPLPPEGASAIVHRTTERAAEMARAQGVRSADLLAAGIADRLLPECPDAAEEPQEFCARAAVMIAEELAALAAADPAVRMAARGRRFDGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A066</accession>
    <name>A0A1H6A066_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42128">
        <property type="protein sequence ID" value="SEG42128"/>
        <property type="gene ID" value="SAMN04489712_105118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG42128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="20825" checksum="F872C2A3C422810B" modified="2017-01-18" version="1">MLTVRARPSWYRAGRVASPLIAFGASVAFVTGGARGGTGFAAMGFLVLGVLGIAFFGAGTVLAAGNLLGRRPVLELDEQGVRRPAPWPRRRRRDRVLPWPQVEALCLVSRGVAARGSRVRDHLVFLSSPQAAEHARTAPKPQLVALVLTDLPGGSEHAPWLLMADPDWNVPLKDIVAEVRRHGVPIIDRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A3N5</accession>
    <name>A0A1H6A3N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43353">
        <property type="protein sequence ID" value="SEG43353"/>
        <property type="gene ID" value="SAMN04489712_105191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="PTHR31250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG43353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="514" mass="55106" checksum="466BAEAE992576BE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A566</accession>
    <name>A0A1H6A566_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43879">
        <property type="protein sequence ID" value="SEG43879"/>
        <property type="gene ID" value="SAMN04489712_105221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010662">
        <property type="entry name" value="Hydrolase_RBBP9/YdeN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06821">
        <property type="entry name" value="Ser_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG43879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="179" mass="19582" checksum="F914F441DF49A0EE" modified="2017-01-18" version="1">MTTVLVLPGYENSGPEHWQSRWEREHPDHRRVEQRDWSFPLVDDWVSALDEAVAAEPGEVALVAHSLGCITAVRWAVADPERARDRVRGALLVAPADVERLPDLPLGSFAPIPRAALPFRTTVVGSRDDPYMSFDRTEEFAAAWGADLVDLGDAGHINADSGLGSWPRGRQLLAALLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AL57</accession>
    <name>A0A1H6AL57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48765">
        <property type="protein sequence ID" value="SEG48765"/>
        <property type="gene ID" value="SAMN04489712_105495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG48765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="172" mass="19635" checksum="BCEEE05664954FE4" modified="2017-01-18" version="1">MRLTSKNAYHGHALCKTPDTEVTSGWWFVPDLRMHLKLHQRWRAEIWLPADSLHLARLQIYDHFSGAEWLDASYPPDTSGVVPFQRADRFMLDGRMPGWGEWPSEPTSNGRVPMLACLYCHSPVSRTEVVVIGPGPVLGRIYPVLTVRAPRAHRSCHRSHQRKQSTADHPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AW39</accession>
    <name>A0A1H6AW39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prostaglandin-endoperoxide synthase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52265">
        <property type="protein sequence ID" value="SEG52265"/>
        <property type="gene ID" value="SAMN04489712_10618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="547" mass="60771" checksum="660BCEF4D2300E4D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYD2</accession>
    <name>A0A1H6AYD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53643">
        <property type="protein sequence ID" value="SEG53643"/>
        <property type="gene ID" value="SAMN04489712_106106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG53643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="213" mass="23635" checksum="68DA80AAC2FE3180" modified="2017-01-18" version="1">MRKLERAVCPKCEQGRLAPVMYGYPDFTDELERMLAAGELVLGGCMPGPERWGCPRCRARYVELPGPDSRWGDIVWGIPVEIQATRGCGPERALVTVRRNDPWTLTFQFDDGLWQRPTIVALGDDLFGAFQGLCRAAAKRGVKLLVNGARRDVHRCQVDAPDTHHLVSLLRPGRPAALSDTANLLDPAPEDGLGTPDEQNDHLARWFRSLPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2L6</accession>
    <name>A0A1H6B2L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55098">
        <property type="protein sequence ID" value="SEG55098"/>
        <property type="gene ID" value="SAMN04489712_106203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG55098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="25620" checksum="2488729554A4EF4F" modified="2017-01-18" version="1">MIEVIGAGLPRTGTLSLKTALERLGFGPCHHMFELFDHPELIDRWLPEVPDDAVGWQRVFAGYRSTMDWPASFFWRELAEAFPWAKVVLTVRDPGSWYASFRALIRLRAASLAEEDPSQAALASRASVARLRPLLEHIAHQTFGNTRPFPEWLPDEDQAVAAFQRYATTVRESLPAGRLLVFDVRQGWEPLCTFLGVAPPLDEPFPRLNDIDALKSRLDRLESDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3Q5</accession>
    <name>A0A1H6B3Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl oligopeptidase Serine peptidase. MEROPS family S09A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55499">
        <property type="protein sequence ID" value="SEG55499"/>
        <property type="gene ID" value="SAMN04489712_106236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="487"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG55499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="703" mass="76993" checksum="E325BF61104B19C4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B4E7</accession>
    <name>A0A1H6B4E7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55713">
        <property type="protein sequence ID" value="SEG55713"/>
        <property type="gene ID" value="SAMN04489712_106252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="56"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG55713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="38605" checksum="C5FCFCD91475A926" modified="2017-01-18" version="1">MAMPTDAPDRNPADQKTADPSTAGRKVADCGDVDLRHHGDSEVGGGLADFAVNVRGGTPPAWLAERIRRSVGDLAAYPDPGPARRAVARRHGRAVEDVLLTAGAAEAFVLLARVLAPRRAVVVHPQFTEPEAALRAAGRPVERAVLDGDFKLDPGRIPPDADLVMIGNPTNPTSVLHPAAEIAALARPGRTVVVDEAFMDCVPGEPESLAAAAVPGLVVLRSLTKTWGLAGLRAGYVLAEPPLVAALAQAQPLWAVSTPALVAIEACCEPPALAEADVWAREMAAERDRLAGELALRGLTAVPGARASFLCVHTPGASELRERLRGRGFAVRRGDTFPGLGPDWLRIAVRDRAADNALLEVLDDLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BGV8</accession>
    <name>A0A1H6BGV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, DUF305 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59999">
        <property type="protein sequence ID" value="SEG59999"/>
        <property type="gene ID" value="SAMN04489712_107103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="65"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG59999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="23296" checksum="060C8E7DF80DCDDA" modified="2017-01-18" version="1">MSGQRWAGLGIAFALVSGLLVGCSGEEEPAAAPKATVIAPGRPGEPNKTITAGPTSAKPPTAAEITFVQMMIPHHQQALEMSVLAPKQASDAKVKSLAERIDVSQGAEISVMQSWLRRQPGGRPGGGHGGHGGHGAPSAAASHAGMPGMATPEEMARLQAAQGEEFDRLYLTLMIKHHEGALTMANDVLSKDGTDVTVQELAKDVLTTQRAEIVRMRDLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLD0</accession>
    <name>A0A1H6BLD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease of the drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61529">
        <property type="protein sequence ID" value="SEG61529"/>
        <property type="gene ID" value="SAMN04489712_107221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="165"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG61529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="317" mass="32579" checksum="D412EDE32B520892" modified="2017-01-18" version="1">MKNEDSATESRPIALGGLGGAGQAALGVLVFSFSLPATVYALDGLDPYLIGVGRAVVAALLGAVALAAVRARPPALRYWPGLLAVGFGVVFGFPVLSTLALDHGASAAHGAVLIGLLPAATAIFAVLRTRERPSPAFWAAAAVGALTITAFTLAEGGGTATVADLLLVGALVTAAYGYAEGGRLAREMPGWRVISWALVLAAPVSVPVTAVLLATTEQEWTARSVIGFGYVSAFSMFLGFFAWYAGMARIGVAKAGQFQLAQPILTLAWSTWLLGERLGGATWPAAIIVVACVAWTQRARVRTAPAVPARPVDVASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BW63</accession>
    <name>A0A1H6BW63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64882">
        <property type="protein sequence ID" value="SEG64882"/>
        <property type="gene ID" value="SAMN04489712_10861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="14"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG64882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="433" mass="45860" checksum="CA6BAEAFD81DC36D" modified="2017-01-18" version="1">MDGARTGEGAARLAWLDALRGLAALAVAFHHATYHYAPGLRRQITAWFDPGMYGVMVFFLVSGYIIPASLERSRSLGRFWVGRVFRIYPLLLFALTAVVVIAATDMWPLRDGLAELDRWAVALAHLTMLQDLLAVPNALNVLWTLSYEMLFYLLVAALFAVGLHRRSAGIAAGLAGGAAAAVALGGLVPATALTKVAGVTPVVTVTALVMAAAIGCAFCRRPQVRAAGAVLGGLLAVVLLAANGRVPLWEGLVILAVMFTGTALYRAERGQIRVRAAVLSAGAVLVVAVAAGLWHMGGWGLPADEVLGLRRAWASALVLAALTFAAGMALRHRAMPRGLTILGVISYSVYLLHPVLLIVSDSLFGRPRQDAPFWLALFLAALVAAALLTQRLVERPAQRLGRRVARRLTSGPTTGANNGTTPHADTDRTALTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYR8</accession>
    <name>A0A1H6BYR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65849">
        <property type="protein sequence ID" value="SEG65849"/>
        <property type="gene ID" value="SAMN04489712_108142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="616" mass="66360" checksum="07C8DB753F2592DE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYT7</accession>
    <name>A0A1H6BYT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65864">
        <property type="protein sequence ID" value="SEG65864"/>
        <property type="gene ID" value="SAMN04489712_108144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="9160" checksum="48CA56E935341C8C" modified="2017-01-18" version="1">MVIGDIVIAVVFGSIVGVLGRLVVPGRRPAPLWLVVVAGVAAAIIGAWLGQVLFGWENGALSFPVVLLQIMLAAIGVFTAATLGLRRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1Z9</accession>
    <name>A0A1H6C1Z9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">corA</name>
        <name evidence="7" type="ORF">SAMN04489712_108188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66386">
        <property type="protein sequence ID" value="SEG66386"/>
        <property type="gene ID" value="SAMN04489712_108188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG66386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="324" mass="36355" checksum="C513DFA3F2E17DDF" modified="2017-01-18" version="1">MIVDKAIYCRGRRHDIEGDISDAFDAARADGSDCWVWIGLHEPTAEELKLVSRELNLHPLAVEDAVNAHQRPKLEHYGDTLFLVLKTLDYREATSGIEVGEIMLFVGADFVVTVRHGTANPLAPVRRRLESDPELLETGAVAVPYAVLDEVVDRYQTVAGEVEVDIIELERAVFSSDGRDVTERIYSLKREVLKFRSAEDPLVPVLQEIVGGRVRELRGPLEYFRDVLDHLLRVDGRVDAHDELLTSVLNAHLALLGKRQNEDMRKISAWAAIIAVPTAIAGIYGMNFKDMPELQSPYGYPLVLMAMAAACLLVYWRLRKSGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2V2</accession>
    <name>A0A1H6C2V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67271">
        <property type="protein sequence ID" value="SEG67271"/>
        <property type="gene ID" value="SAMN04489712_108270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294385" evidence="1">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG67271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="15300" checksum="82DFAD3106183D31" modified="2017-01-18" version="1">MFDQRSDATRARRAGAVLGVAAAALLLAPTAAFSATQAPQALPAGVVKLNDGEGCPSMTLCLYRDYDRRGPAYGIGAGYTVDLSQLPMGSGTAANNISSWVNMTRYTAALIDRDKNRIRLLLPGESLEEPMSSNDSVDEVSWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8N3</accession>
    <name>A0A1H6C8N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68995">
        <property type="protein sequence ID" value="SEG68995"/>
        <property type="gene ID" value="SAMN04489712_10939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="488"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="635"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG68995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="782" mass="83168" checksum="E440DCC5C2AE35DE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCY9</accession>
    <name>A0A1H6CCY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70851">
        <property type="protein sequence ID" value="SEG70851"/>
        <property type="gene ID" value="SAMN04489712_109212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="121" mass="14204" checksum="DF5EC7CE4F2C2E89" modified="2017-01-18" version="1">MPHATATLEAIVRSYYDHVDAHRLEELLALFDEDIVYERQGTPRIMGIAALRRFYEQERIIDSGAHTLDQVLTGAEWVAVRGRFDGRLRDGQQVRIRFTDWHHFREGRIVRRESLFPGRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CD26</accession>
    <name>A0A1H6CD26_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalt transport protein CbiN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Energy-coupling factor transporter probable substrate-capture protein CbiN</fullName>
            <shortName evidence="10">ECF transporter S component CbiN</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cbiN</name>
        <name evidence="13" type="ORF">SAMN04489712_109156</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CbiN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70266">
        <property type="protein sequence ID" value="SEG70266"/>
        <property type="gene ID" value="SAMN04489712_109156"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00330">
        <property type="entry name" value="CbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003705">
        <property type="entry name" value="CbiN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38662">
        <property type="entry name" value="PTHR38662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02553">
        <property type="entry name" value="CbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01165">
        <property type="entry name" value="cbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 10" id="KW-0171">Cobalt transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294706" description="Cobalt transport protein CbiN" evidence="12">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG70266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="11307" checksum="F38AF862D8374825" modified="2017-01-18" version="1">MKRGTVVNLLIVLVVVALAVAPLAMGAGDGKEEPFAGADGQAETAITENDPGYEPWFAPLYEPPSGEIESALFALQAALGAGVLGYYFGVVRTRRRLAAEVTARQGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJY2</accession>
    <name>A0A1H6CJY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain-containing protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012850682.1">
        <property type="nucleotide sequence ID" value="NZ_FNVO01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73279">
        <property type="protein sequence ID" value="SEG73279"/>
        <property type="gene ID" value="SAMN04489712_11091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7475" checksum="2EC287622235D8DE" modified="2017-01-18" version="1">MSARTPEAEPLLTPAEVATMFRVDPKTVTRWAKAGKLTSIRTLGGHRRYREAEVRALLAGIPQQRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CK24</accession>
    <name>A0A1H6CK24_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73351">
        <property type="protein sequence ID" value="SEG73351"/>
        <property type="gene ID" value="SAMN04489712_11099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP_3" evidence="1">
        <location>
            <begin position="54"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="149" mass="15590" checksum="1BA1DEFC1620678C" modified="2017-01-18" version="1">MSRSPLSRAVLNERLAALGRPPYEGPDEPAALRLAALNAVLAALDSGVEPGRPDRPLVRGAVRVLLDRLAAASPGRSVEVRVPPYAAVQCVAGPRHTRGTPPNVVEMDATTWIRLATGRLSWDEAVANGLVRASGARADLSALLPVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNG9</accession>
    <name>A0A1H6CNG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FGGY-family pentulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_110243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74569">
        <property type="protein sequence ID" value="SEG74569"/>
        <property type="gene ID" value="SAMN04489712_110243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="256"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG74569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="515" mass="54543" checksum="8C9BF90382109F68" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQK9</accession>
    <name>A0A1H6CQK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, MSMEG_4141 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75262">
        <property type="protein sequence ID" value="SEG75262"/>
        <property type="gene ID" value="SAMN04489712_1116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="140"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="30792" checksum="1986C5AF549CC2A0" modified="2017-01-18" version="1">MLMELSGVGIWSQQLRYGDPGEAAEAAAELEELGFSALWVPDVGGPLFDAVGRLLAATRSAVVATGILNLWMHAPADAAASYASLTDAHGARFLMGIGVSHAPLIDADEPGRYRRPLAAMAGFLDGLDSADPPVPATERVLAALGPKMTALAAERARGVHPYLVTPEHTRSAREALGEGPLVLPEQTVILCSGAEEARAIGVDWLRGYLGLPNYANNLLRQGFTPEDVASVSDRLFDALIAWGDEEAIMRRVDEHRAAGADHVCVQVLTADSRTFPREQWRRLAAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT81</accession>
    <name>A0A1H6CT81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hexapeptide repeat of succinyl-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75646">
        <property type="protein sequence ID" value="SEG75646"/>
        <property type="gene ID" value="SAMN04489712_11167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="28346" checksum="C4F45F3DF1CA9DBA" modified="2017-01-18" version="1">MSLKHVLATRARRCLHTAVHRGWEWVQRQGEITPSTPGRHRFAYLGEGACIGFPSGAIYGEPWISIGDHTLIGTHVTISAGFVPGLDLGPDLVVRIGSSCSLGRGTHIVGHQSIEIGNDVFTGPNVYITDQNHSYGDLDMPIGRQWPENNPVVIGDGCWIGTGAIILPGTRLGRNVAVAGGAVVRGEFPDHCVIGGVPAKVIRRHDPDEGWLPPMRSRSPLVSLDELAKLSTEGLAGLQILQDKLREQDRLRAQEDLTEEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUU2</accession>
    <name>A0A1H6CUU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MinD-like ATPase involved in chromosome partitioning or flagellar assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76734">
        <property type="protein sequence ID" value="SEG76734"/>
        <property type="gene ID" value="SAMN04489712_111199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="66"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="310" mass="33267" checksum="46FEFA121EB495D2" modified="2017-01-18" version="1">MPQTADSLSAETLLRGRRNAPTGGWRKMLYKATGGAIHPGESPAELRRRELVARASTPVAGGHHRVAVMSLKGGVGKTTTTVGLGATLASLRGDRVIAVDANPDRGTLSDKVRLETAATVRDLLNERDQIQRYADVRAFTSQATSRLEVLASDRDPAVSEAFSADDYRAVAEVLEHFYSICLTDCGTGLLHSAMAGVLSLANQLVLVSSPSVDGARSASATLDWLEAHDHGDLVRNGVVVLSMVRARSKSTVDLDRLQAHFESRCRGVVRIPYDDHLEEGAEVELDLLSPECQDAYLQLAAVVGDGFAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV82</accession>
    <name>A0A1H6CV82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76316">
        <property type="protein sequence ID" value="SEG76316"/>
        <property type="gene ID" value="SAMN04489712_111149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="18529" checksum="914167386E9D8698" modified="2017-01-18" version="1">MISLTPATLNDAEIDEMHAVCSTNRLYWQYSGDLDPDDISRDAVAAMLREEAGTGGQELRIARDRTGRLVGFTALLLRHPVDGHPWIGLLLVDGRLRRQGHGRAIATALEQRFRTEGEPGIRLGILENNTEARRFWTALGYHEIDRRPDLAKGRPTLVMHKDLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CWW7</accession>
    <name>A0A1H6CWW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77243">
        <property type="protein sequence ID" value="SEG77243"/>
        <property type="gene ID" value="SAMN04489712_111269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="31491" checksum="0EA1B857595E7FEE" modified="2017-01-18" version="1">MDMRALVVDPEVPGSLRLGTTAEPHPAPDQLVLEVRHISLNRGEVAFAGHRPPGTVHGYDAAGVVVGAAADGTGPAVGTRVAAFGTGAWAQRMAVDTTAVAEVPAKVDLADAAALPMAGITALRTLRSRSILGRRVLITGAAGGVGRYAVQLAALGGAHVIASVGSAARGEGLTELGADEVRVGLEGIDRPVDLILDTVGGRQLTAAWQLLAPGGDVQSIGWASDEPAMFAPHSLFSLGPAKTISTFGDTHEVGPDLATLLEFVAAGRLSPEVDWRGSWERVTEAARALLDRRIAGKAVLNVEPAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZE2</accession>
    <name>A0A1H6CZE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78382">
        <property type="protein sequence ID" value="SEG78382"/>
        <property type="gene ID" value="SAMN04489712_11270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="1">
        <location>
            <begin position="30"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="44258" checksum="7D0DAEB3952A3181" modified="2017-01-18" version="1">MSDQPVKAELDLSDVDHRVGKPVGGGQLWEPCSASDIRRWVMAMDYPNPLHWDEEFARETRFGGIVAPQSVAVALDYGHGAQPACVGHIPGSHLIFGGEEWWFYGCSVRPGDKLFQERRFHDYKVVETKFAGPTMFSRGDTIHRNQHGALVARERSTAIRYLASEAEKRGMYENQLGAVKRWTATELDEIEKVRHDWILSNRTGVSPHFEEVNVGDRLPRRVIGPHSIAGFTTEYRAFLFNIWGTFHWVAPPGVEDPWINQDPGWVEGFAFDEEGARIDPRKRDGLYVGPSRGHIDADKAGEVGMARAYGYGATMGAWCTDYLAYWAGHDGMVRHSKADFRGPAFEGDVTYFDAEVVGKQTESSWGVPLVQVKLRLTNQDGGVLVDCTAEIELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZG2</accession>
    <name>A0A1H6CZG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78217">
        <property type="protein sequence ID" value="SEG78217"/>
        <property type="gene ID" value="SAMN04489712_11248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG78217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="390" mass="42841" checksum="62D53B00F693FD4B" modified="2017-01-18" version="1">MKANCWMGRNSVEVTEVPDPKILNSRDAIVRITSAAICGSDLHMYDGYIPTMKKGDILGHEFMGEVVEVGPEVTDLRPGDRVVVPFPIACGRCWACEHELYSVCENSNPNAGLAEKFMGHSPAGIFGYSHMLGGYAGGQAEYARVPFADFGPLKVDGDLSDEQVLFLSDILPTGYMAAEMCDISPGDVVAVWGAGPVGQFAVVSAYLLGAEQVICIDRFSYRLRRIHEHTGAEIVDYEEVDVMEALKEMTAGRGPDACIDAVGMEAHHPTGPIHAYDRAKQATRMETDRPHALREAIMACRNGGIVSSVGGYGGFVDKFPMGSFMNRSLTMRSAQCHVQRYMRPLLERIRRGDLDPTFVISHRMPLEEAPQGFELFKSKRDECNKVVLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZR0</accession>
    <name>A0A1H6CZR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78669">
        <property type="protein sequence ID" value="SEG78669"/>
        <property type="gene ID" value="SAMN04489712_112109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="27190" checksum="343EF105CB3C354F" modified="2017-01-18" version="1">MRIAQDRRALVTGGGAGFGRRIARRLHEAGAMVAVLDIDGERVKETVADLGARSLGIAADVRSAAEMRAAVARTVGDFGGLDTLVVSAGVFHVGTLEETDEDDWDRTLDVNLKGAFMTVKAAAAALRESGRGRIVTIGSDCGRRGFPGQAPYVASKFGLIGLTESVAAELAPAGVTANCVCPVGCPTTEMGRQVLDWKTGRTGLSVERIMEATAATNPLGRNATEDDVADAALFFLSDQAGFLTGVTLDVDGGARLGAIPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D432</accession>
    <name>A0A1H6D432_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79386">
        <property type="protein sequence ID" value="SEG79386"/>
        <property type="gene ID" value="SAMN04489712_112208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295555" evidence="1">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="14167" checksum="4FA4AE0021D1AC1F" modified="2017-01-18" version="1">MDLVAVLVAVLVVCQAAVLVASQEAVQADQVIHLRLRETGPTFQVDLVTRTIRVDLVAQITQAGLVTRTIQVDLVVPITQAGLVARIIQAGRPIRSAVVAAIPTCRTCPVVAVAVSVVFQAVAAVVCQAVALAASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D687</accession>
    <name>A0A1H6D687_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80792">
        <property type="protein sequence ID" value="SEG80792"/>
        <property type="gene ID" value="SAMN04489712_113153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="15"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="333" mass="36581" checksum="FD4D272000AEAE07" modified="2017-01-18" version="1">MEYTQLGRTGLTVSRLVLGTMNFGPYTDEADSHAIMDAALDAGINFFDTANVYGWGEDKGRTEEIIGTWFAKGGGRRDKTVLATKVYGNMGAEGSRWPNEDRLSALNIRRAAEASLKRLGTDHIDLYQFHHIDRRTPWEEIWQALDVLIQQGKVLYVGSSNFPGWGIAQANEAAARRHSLGLVSEQCLYNLYERRAEMEVIPAARNYGLGVIPWSPLQGGLLGGVLRKQSSGEGGQTRSSSGRTAEALNDPAVRDRIQAYEDLCDKHGFEPGEVALAWLLTRPGVTGPIVGPRVREQLDSALRAAELKLPEEFLATLEEIFPGPGPAPEAFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8S9</accession>
    <name>A0A1H6D8S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81847">
        <property type="protein sequence ID" value="SEG81847"/>
        <property type="gene ID" value="SAMN04489712_114157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="32" mass="3665" checksum="F7A55971E2ABBFCB" modified="2017-01-18" version="1">MGWRLLVVLAVLTTAVWWGLSRRAHRCSARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBT3</accession>
    <name>A0A1H6DBT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_115106</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82917">
        <property type="protein sequence ID" value="SEG82917"/>
        <property type="gene ID" value="SAMN04489712_115106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="127"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="254"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG82917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="378" mass="39772" checksum="4FB6666C1144763A" modified="2017-01-18" version="1">MKFRIDHHDLAEAVGWAARTLPARPALPVLAGMLIEATPDGVTLAGFDYEVSARAAAEAAVSEPGRVLVPGRLLAEIVRSLPAQPVEIFTEGAEAVVRCGSVEFGLLTMPVEDYPTLPEPPASAGTVPGEAFATAIAQVVVAASRDDTLPMLTGVRVDIEGEVIRLACTDRYRIASCELRWSPVSAGFSAAAVVPARTLADVARSLRAGTEVALSLTGAGDSLLGISAAGRSMTTRLLDDQFIDYRARLVGEWTSVAEVATAPFVEAIKRVALVADRNVPVRLAFTQGSVRIRAASGDAARANETLSADLDGDEVDIGFNPQFLLDGLAGITSMTTRLHCNGPTKAALLTPGPAQDDEADVEQDDAYRYLLMPIRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE90</accession>
    <name>A0A1H6DE90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_11617</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83541">
        <property type="protein sequence ID" value="SEG83541"/>
        <property type="gene ID" value="SAMN04489712_11617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="136"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="247"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG83541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="399" mass="43391" checksum="9308765AF573D1FE" modified="2017-01-18" version="1">MLEWSDEDLMIRDAIRGWIDAEVRPHLDALDSGELPPYDLIRNLFRTFGMDEMARSSFKKRAAGEGSGRSDGSGGSGGNPSMSILPIVELCKVSPGLVTAMGVSLGLAAGTIMKRGTPEQRERWALDLLTFDKVGAWAITEPGSGSDAFGGMRATARKVGDEYVINGSKTFITNGPHADTIVFYCKLDDGRDPRDREILTFVLDRGMPGLEQSRPLRKMGLHSSPTGELFLTDVRAGADRLLTGGGGDGKASAKQNFVTERAGVAAMALGVIEECLRLSVDYAKTRVLWDKPIGDYQLIQLKLAKMEVARLNVQNLVFRHIEMQRAGRTPTLAEASAMKLYAAQAAAEVAGEAVQLFGGNGYMSEFRVEQLARDAKSFQIYAGTDEIQITHIARDLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGT4</accession>
    <name>A0A1H6DGT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84588">
        <property type="protein sequence ID" value="SEG84588"/>
        <property type="gene ID" value="SAMN04489712_11729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="419"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="515" mass="55929" checksum="D54E5DA8978BFC2E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DI42</accession>
    <name>A0A1H6DI42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84862">
        <property type="protein sequence ID" value="SEG84862"/>
        <property type="gene ID" value="SAMN04489712_11781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="25916" checksum="9AAA028D36DD4BB3" modified="2017-01-18" version="1">MPAFQRAIDLGYRYLETDVHATADGVLVAFHDRTLDRVTDRRGAIARLPYAQVAKARIAGVEPIPLLEDILGSWPDARVNIDIKEAPAIAPLAAALHRTRAWQRVCITSFSTRRLAALRARLPLFTDQDVCTALGPRGVMALRARSAGGPAAKLVRLASTGVACAQVPYGLGRVPFVTEAFIAQAHELGLKVHAWTVNDRAEMERLLDLGVDGVMTDDLLTLRDVLTARGQWYPAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DI77</accession>
    <name>A0A1H6DI77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_117153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85167">
        <property type="protein sequence ID" value="SEG85167"/>
        <property type="gene ID" value="SAMN04489712_117153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="12138" checksum="415C7D3A114EA518" modified="2017-01-18" version="1">MLPAEFAALEPYGDWILETERERYEKRLASSMEEMQAFYDAAFPLLESASKHLDAFTVGELPEPERNLLLLMFSLVMVSFPIEVWKQARVPDSGAAYLDLLVEPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKC0</accession>
    <name>A0A1H6DKC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85561">
        <property type="protein sequence ID" value="SEG85561"/>
        <property type="gene ID" value="SAMN04489712_11833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="723"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="762"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="807"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="852"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="984"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1065"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1109"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1154"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1199"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG85561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1269" mass="135647" checksum="570F83F65315F4CB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL49</accession>
    <name>A0A1H6DL49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85861">
        <property type="protein sequence ID" value="SEG85861"/>
        <property type="gene ID" value="SAMN04489712_11894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="13520" checksum="E88CAEBD81FC62BD" modified="2017-01-18" version="1">MEVLWAREDAGGGAATARDVSRALAGDRDLAHTTVMTVLDRLAKKGFLERERDGRAWRYRPAASREGYVAELMLGALDQTGDRDAALAHFVRSVSQDEVAVLRQALEEINSIQLNRTRVEPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLA2</accession>
    <name>A0A1H6DLA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_118108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85921">
        <property type="protein sequence ID" value="SEG85921"/>
        <property type="gene ID" value="SAMN04489712_118108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG85921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="35630" checksum="6AFB23455B015807" modified="2017-01-18" version="1">MVRRSPTPTVRRYDPRSEERWPYDAAQPYALPPRGRRPRRSLGGAVAGILGVVAAILVLAVLGLAAFTDGGAVAARIRNDPAQIPAETATANPLYRTGPLTPVGCRLPRIRPGSDESMRRFMDTLSQCLDRSWQQQFGKADLTFEPPKRIFWNTPGRGPCGSFPSPGAAAFYCPENDTMYVGLRHIVETSGGEPVSHYAVYARVIAHEYGHHVQEQAGILAYGHQRMDAAAAAASAAGSTEISRRIELQAQCLAGVFLGAERGTLPMTRAQYVALMIDLRARGDDRQPADKRDHGSGRSYAGWVEKGYRERVVGTCDTWTVPAAQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DM38</accession>
    <name>A0A1H6DM38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86249">
        <property type="protein sequence ID" value="SEG86249"/>
        <property type="gene ID" value="SAMN04489712_11932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="375" mass="39069" checksum="1CBBE1428517ACD7" modified="2017-01-18" version="1">MDAIIIGAAETDVLGRNPDQSVLGLNVEGGLRALADAGLEPGQIDGVAGAYSPHGVAHALGITPRWVDSTNVGGCSFLMHVRHAAAAIAAGHATRVLVTHGESGRSRAGTVPRPRDPQSWTGQFEEPYGAKPPYTRFTLPALRYLHDNGLDETALAQVVVAQRRWSSRVPRAGRRDLMTIDEVLAAPALAWPFTVPMICMLTDGGGGLVVTASEHATAEQLRRSVKVLGTGESSDPLLVAQVPDPVGDSAARRAADDAFAEARIGRSEIGHVMVYDAFAHLPLIGLECLGLAPVGKAAELVAAGETSPGGSLPLNTNGGGLAYTHTGMYGMFAIQEAVRQLRHEAAAQVPDVSTSAVLGYGGMFTASSVLILARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMP7</accession>
    <name>A0A1H6DMP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86509">
        <property type="protein sequence ID" value="SEG86509"/>
        <property type="gene ID" value="SAMN04489712_11999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="26856" checksum="B24548B09133029A" modified="2017-01-18" version="1">MIDALGVPQSVLLLGGTSEIGLAIVDRYLDRRPVRVVLAGRPSERLDSAVARLTARATRVDTVDFDAKDLASQQTALQQSFSAGDIDVAIVAFGVLGDQPAPENDPATAAHLATVNFTAAMNVGIILARAMRRQGHGVIVALSSVAAVRPRHSNFIYGATKAGMDAFYRGLADSLDGSGVDVLVVRAGPVRTRMTAHLPDRPLTSSPEAVAAAVTEAVWRRRTVLWTPRSMRIIAWIIRLLPRRLLRKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPM0</accession>
    <name>A0A1H6DPM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_120110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87317">
        <property type="protein sequence ID" value="SEG87317"/>
        <property type="gene ID" value="SAMN04489712_120110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="295" mass="32393" checksum="086FECCEF1A5E0EB" modified="2017-01-18" version="1">MDLATVAHELYEVRPEEFTDARKRLVTAARSAGDAGLAGRIGRLRKPTVSAWAVNRLSRAAGDDLAGLLRLGAELRAAWSSGGPIAELEQRRGEIVARLLRTAERLAADAGRPLRETALREVEDTLQAAAVDPDVAEEVRTGTLDRPRSHTGFAPAAFAVPPGPPTSPTSPAPSGKDGPPATLREPPKPSKAPREQRAERERQRRAEAARAAERRAEEADRARAEWESEVAAARRELDERTAETDELRRRLDEALDRREAAERRVHVAHRELARASRAADEARRRAAETARTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPU8</accession>
    <name>A0A1H6DPU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty-acyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_120126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87407">
        <property type="protein sequence ID" value="SEG87407"/>
        <property type="gene ID" value="SAMN04489712_120126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030310">
        <property type="entry name" value="FadD17/FadD6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="PTHR43107:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="17"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="4">
        <location>
            <begin position="423"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG87407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="551" mass="60636" checksum="70960D309C01C2FE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQ69</accession>
    <name>A0A1H6DQ69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_120143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87492">
        <property type="protein sequence ID" value="SEG87492"/>
        <property type="gene ID" value="SAMN04489712_120143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="41" mass="4194" checksum="CCE1C7927BCC93FC" modified="2017-01-18" version="1">MGKHAKKVDCSSCSGTGKMKIGNNGTTTTIKCTMCKGTGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQE7</accession>
    <name>A0A1H6DQE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86933">
        <property type="protein sequence ID" value="SEG86933"/>
        <property type="gene ID" value="SAMN04489712_12036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="102"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16609" checksum="CD720FF4B63B49F5" modified="2017-01-18" version="1">MPSKSDSGGACVFCEIIKGTRPAHLVMETEDAMAFLDARPLYKGHTLLVPKEHYETLPDLPPELVGPLFGYARRLATVMETGLGAAGSFVALNNRISQSVPHLHVHVVPRNRKDGLRGFFWPRTKYASEEEAAGFAARLREALRDPAEPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRQ1</accession>
    <name>A0A1H6DRQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_120105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87295">
        <property type="protein sequence ID" value="SEG87295"/>
        <property type="gene ID" value="SAMN04489712_120105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG87295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="239" mass="25035" checksum="39CC7BBB121E676A" modified="2017-01-18" version="1">MDNSSGVGVLDKAVLVLNALEAGPASLASLVQTTGLARPTAHRLAVALEHHRLVHRDAQGRFILGPRLAELAVAAGEDRLLAIAQPVLAQLRDLTGESAQLYRRQGDVRVCVAAAERSSGLRDTVPVGSALPMTAGSAAQILLAWEEPDRLHRGLRGAKFEAATLASVRRRGWAQSVGEREQGVGSVSAPIRGTGGRVVAAISVSGPLERLTRSPGRLHAAPVVAAAERISEAMRRTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTH5</accession>
    <name>A0A1H6DTH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88647">
        <property type="protein sequence ID" value="SEG88647"/>
        <property type="gene ID" value="SAMN04489712_12251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG88647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="43126" checksum="FA8D196501C41725" modified="2017-01-18" version="1">MEFGAGTPLEEFRGQVRAFVAAHAPGYKVRSGVRSPENAAELKELQRWTAELYEAGYLGADWPAEYGGAPDHDPLRAFVVGEEIARARAPMPASGSSLAAHALIRFGTEEQKRRYLPRIRSGEDLWCQLFSEPDAGSDLASLRTVAVRDGDEWVVSGQKVWTTNGHWSGYGYLLARTDPQAPKHKGISAFVLDMKAPGVQVRPLRELTGTSDFNEVFFDEVRLPADAIIGAPGQGWLIANASLAEERNGVGASVVQLQLAWKDLVEDARGVTVDGRPALECDDVRQRLAALRAEVDACELLAHTSLARWNAGRERAADAPITKLYFSELNLRIAEYALSLLGASGVLAEGDPDAVADGRWQDAYLYARAYTIAGGSSEIMRNIIAERGLGLPREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX68</accession>
    <name>A0A1H6DX68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89674">
        <property type="protein sequence ID" value="SEG89674"/>
        <property type="gene ID" value="SAMN04489712_12423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="380" mass="39995" checksum="640F43491C838AF3" modified="2017-01-18" version="1">MNELQMISEMLDETPAEQTAAQGRRRLLSEIANPRPAAPARRRFPLPRWSPGLGLAGLAGVAAASVAVAVAVSGTTSPAPQSPGQTATGELSARTILVAAAEQAESTTETTGKYWHTATIDRHSFRVGKGDGAYTVVWRQRSEGWTPSTPGGKQYGRQQDLGATPATPADTAAWRRAGSPATFSVSVPVGPGSKVRKPLKLKTQPGSPHLSGSPLVDRDKVFWLGRNVTVKDLRALPADPAKLKASLLKWYRGHGTESSGQAMTSDAWLFEVTRGLIVDMPVTPKVRGAAFRMLADLDTVKAIGPVRDGEGRTGTAVATTERTPNGVLEHRLIIDQRRGTALGTQIVVVRPAGANAALPAGATLVSTSVMAGGWTDTGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXG0</accession>
    <name>A0A1H6DXG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89764">
        <property type="protein sequence ID" value="SEG89764"/>
        <property type="gene ID" value="SAMN04489712_12456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="31662" checksum="CF90B756197DA5AF" modified="2017-01-18" version="1">MPTREHEIWLELIQERPSLAADLLRLVHPEVPDFEEARVESGALNDYKPTEYRADSVVSLLSGNNPALALIVEVQRGPVKEKRWSWPAYLGTLWSRRRCPVALLVICPDRGVARQARVPIQMGHPGLVITPLVLGPDEMPTIIDPDEATRNVELAVLSALVHGTEPEAEKVFAGMFDVFHRAGLDGTAEAQAYIDELLAMLPQAAGKLLEAIMQTKQHEYKSDYFRRAKAEAEAEGLAKAVLTVLDSRGVEVTDEVRARIVGCTDLEQLGVWLRRAVSAASAGDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXR7</accession>
    <name>A0A1H6DXR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90078">
        <property type="protein sequence ID" value="SEG90078"/>
        <property type="gene ID" value="SAMN04489712_12532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="29569" checksum="0E53F0A16B79F68F" modified="2017-01-18" version="1">MSESVEAADLEAHCARVRERIVEMCASVEGGHLGGSMSLVEILVALYFAVLRVDPAEPEAPGRDRLVLSKGHAGIGLYAVLAERGFFPAEDLAGYAEPGGRFSAHPTPAIPGVEVPTGSLGHGLPLGVGFALAARLSGSARRCFVVLGDGELQEGSVWEAAMAAASLRLDGLTAVVDRNGLQITGGTEDVVGLEPLADRWRAFGWAVVEVDGHDLGALVDVLGKPGPPDRPVAVIARTVKGRGLPFVEGQVRSHYARLGDRQRRRAHAVLRAARRADGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZR8</accession>
    <name>A0A1H6DZR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90155">
        <property type="protein sequence ID" value="SEG90155"/>
        <property type="gene ID" value="SAMN04489712_12554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="22956" checksum="0CE533C2C44FF5C8" modified="2017-01-18" version="1">MASSRGRIDKRQAILDGAFTVFARQGYAQACVQEIANEAGVAKPTVYNHLNDKATLFRHAMQAAAQTALHQRLAALEPLADPDPDLRVTLEDVGHRLLRLHTDDRSCALRRLLYSEITQFPDFLDIVTESGPHRLNQALADRLARLTLAGHLRATDPDQAAEQFMALLTGPLEARTRMGTRQIGDAELHEITRAAVRTFLHAFGTADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0H9</accession>
    <name>A0A1H6E0H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90704">
        <property type="protein sequence ID" value="SEG90704"/>
        <property type="gene ID" value="SAMN04489712_12714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="29774" checksum="BC3DC5C57EC7E9DE" modified="2017-01-18" version="1">MKASQSTVAGGSNGASTGATALGRGGLGASTGQRLPVPPRERKPALAALAVLLILGGALTSAYLVIVSGQRVSAIQIAEPVAAGQRIPLRALREVQVGDTGIQFVNWSERAKVATAYAAVPLVEGTLLTGGMVSPVNDAAKGRVVVGLALKPGQMPADGLKSGVKVGLYAVGSGQGGGPRPGTLLSGDAIVVAVRAGGSERLRSDQTMVDVAVPPADAPQLTQAASAGAVAAAVVPEGSRAAPSGGGNKPNGSGNDNDDDTAETPSAGPQSPGTGQGTGQDQGTGQGTGQGQGTGQGTGRTNNPTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0Y7</accession>
    <name>A0A1H6E0Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">23S rRNA (Adenine-N6)-dimethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91278">
        <property type="protein sequence ID" value="SEG91278"/>
        <property type="gene ID" value="SAMN04489712_12879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="5">
        <location>
            <begin position="36"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG91278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="30165" checksum="6B15569F7C08A32A" modified="2017-01-18" version="1">MNRRPRPGTGVPAGRTARDRARRTLSQNFLIDPATIHHYARTVTDDLPGGALVVEVGAGDGRITTALAERAGHVIAYEIDPVLAGRLRAACAPLGNVRCVPGDFLRARPPQGPFHLAGSIPYAVTSRIVDWALAAPGLVSATLITQLEYARKRTGDYGRWSRLTVQTWPVFGWRLAGRIDRRLFRPVPRVDSAILRVDRRARPLLPPGALPAYRRCVEVGFGGRGGTLHASLRGVHPRSRVDDAFGAAGLDRGTVVAYVHPDQWVRLFQVLHANRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1I6</accession>
    <name>A0A1H6E1I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91470">
        <property type="protein sequence ID" value="SEG91470"/>
        <property type="gene ID" value="SAMN04489712_12927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="418"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="511" mass="55783" checksum="34C34F51D143B8C0" modified="2017-01-18" version="1">MDNGVLCGETFTPYPTLRERSARTASALAELGIGAGDTVAVLMRNDVPFLEAAYGASLIGAVPVPINWHGRQAEVRYILDDAHARLLVAHADLLHGIRDALPERLPVRAVPTPAHIADRYGVPDELRAPGAEDVEWSAWIESFEPRTAPPTAPPWGMLYTSGTTGRPKGVLRQPTDLNDPAAVRAMAALHAAIGMEPGARTIISGPMYHTAPFTYAVGMPAQGAFVVLQPRFDAEELLALIERHRITHLYLVPTMFVRLLQLPAQTRNAYDLSSLVKVMHAAAPCPPSVKRAMIEWWGPILHEYYGGTESAAVVACDSEEWLAHPGTVGRPVDGATVRIYGEDGTVLAPGQVGDIYVRLNGLPDFTYQGQPEARVEIGRDGLVTCGDVGYLDEDGYLYLCDRKRDMVISGGVNIYPVEIEACLTRLVGVKDCAVFGVPDAEYGESLAAAIELLPGAELTEDQVRAHVRRHLAGFKVPKLVVFHESLPREDSGKIFKRLLREPYWAGRERRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E253</accession>
    <name>A0A1H6E253_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91758">
        <property type="protein sequence ID" value="SEG91758"/>
        <property type="gene ID" value="SAMN04489712_13042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="131" mass="14223" checksum="1B20681804F6BAF1" modified="2017-01-18" version="1">MRLAPHEQHLPGPRPRPDSTDLQGLTLRQVAKWAEGQARWLASYLDLDHEDPRVFLLAQAAKFGEEAGELHAEVLGHAGIHRRDKAGQYSQDSLGAEMADVIVCVALLAALTGTDLNAAVTGKIAQLNARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2V4</accession>
    <name>A0A1H6E2V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91867">
        <property type="protein sequence ID" value="SEG91867"/>
        <property type="gene ID" value="SAMN04489712_1317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="61" mass="6566" checksum="754F47AD53FDD49D" modified="2017-01-18" version="1">MTRDAPPVPTADKLRLPDARAAPGVDEEVVGHGLSGSLSRPDRQAHRQSPETVGTPERRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3Y2</accession>
    <name>A0A1H6E3Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92360">
        <property type="protein sequence ID" value="SEG92360"/>
        <property type="gene ID" value="SAMN04489712_13327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="31874" checksum="DFFD1B08F4967E7E" modified="2017-01-18" version="1">MCGLFGLLRSPSAAHPERASDAFVVLGTLAEERGGGSCGVALFTGRPVTCGAPVPPGLGDLSVDGCRIVRGRGGFGRVWRPEPLLPLLDHAPIALGHTGWAVPAREEAGPLVVPGPGAGIVAAHGGDVEAAALGERFGTPAGRDGTGGEAIFRALAGRQDLAAITEVLSALVGRAALAWVDRARPDRVHLARAALSPLAVAVDTERNMYWASNPRWFREVRQHTAVEFASAVMLREGTYLEIGRHPAPGVRARAGFLPTARPGDLDERVWAGFTDADRDRDRAGLRHAVHRRPAGDGTGGFAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4J9</accession>
    <name>A0A1H6E4J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kynurenine formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91926">
        <property type="protein sequence ID" value="SEG91926"/>
        <property type="gene ID" value="SAMN04489712_13131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="31398" checksum="B303428CC05A1FC9" modified="2017-01-18" version="1">MNVVDLTHPWGIHTPGWVGYPGCKIYYTQTLQTNRIVSQRIETSLHTGTHLDGPMHAADGGADMASLPLDKLLHEGVVVDVSDQVGDWDVIKPEHITSKIEVKKGDIIIIHTGFHQYYTGGPKQDLVRYFGMHPGGGVELAEWMLDMEIRWWGIDAGSGDHPINTTIRHMRPDLTKRFEEHVGMSAEEYFGEYEYTHHLSGRRVKEDLFPMHYLAFPGGCIHAENVGGDIDAVLDQRVVIGAFPWKIEGGEGCPCRIMAFTDIGKNEVVDVVAGRELPCPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4Z9</accession>
    <name>A0A1H6E4Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92752">
        <property type="protein sequence ID" value="SEG92752"/>
        <property type="gene ID" value="SAMN04489712_13520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="30563" checksum="0515917930EA452D" modified="2017-01-18" version="1">MSDLDFTGKTVIVTGAGRGLGRAYARLLASRGANVVVNDLGGDTDGADPSPGPAALVVDEISAAGGSAVTNAESVASEEGAQSIVATALETFGRIDAVVNNAGNYRLASFEELTLDTVQAFLDVHYKGSLLMARAAWPHLVKAGEGRIVNTVSAAMAGVPDMVHYGSAKGAVYGLTRNLAVAGATHGIKVNAVAPGAGTRMMDLAAAALPPGTAEYMKEHMPPEMVAPVVAYLAHPACSITGEVLNAAGGAVSRQVMMTTRGIHGPGLTPETVAARIEEICDITEAQVAELMIADQAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6W8</accession>
    <name>A0A1H6E6W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93558">
        <property type="protein sequence ID" value="SEG93558"/>
        <property type="gene ID" value="SAMN04489712_13930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="28560" checksum="AFFAD3E8215CE60A" modified="2017-01-18" version="1">MTAYSFDHLAIAAPDWSPAGPWLASVLGGRWGHGARMPHMDVCQLHFGNDTRLELLSPGSSPDSFVRRFLEQAGGRPRPHHLTFKVTDIKRTLDAAVEHGIEPILVNLEHDVWKEAFLHPRDTGLGFLVQFVESAIDPTTVESDAHVPAPWSDRVDGRPADVDFVLARVPGLTTQRPVLRDILGGREEELDAPGGRRIVRFSWSRGADVILVTGTDPADGFGVRSIGVRPGESLDLPLSPLGPGYRETGRLDLLGLSLIVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7U9</accession>
    <name>A0A1H6E7U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92925">
        <property type="protein sequence ID" value="SEG92925"/>
        <property type="gene ID" value="SAMN04489712_13615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="4">
        <location>
            <begin position="277"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="404" mass="42447" checksum="56C63A1C733F13F0" modified="2017-01-18" version="1">MNEAVICRPVRTPIGRFGGALRTVPVQELGVTVVQALMERSGLDGALVDDVVFGHCYGTAEAPAIGRVIALDAGLPTTVPGVQIDRRCGSGLQAVVYAAAMVRSGAAQAIIAGGAENMSQAPHYSLTARWGSRAGDITLTDTLTRGRTTAGGRSYPVPGGMLETAENLRREYKIGREEQDELAYRSHRRALDAQDRGAFTEEIVPVKVSTRKGDVVVDTDEHPRRDISLEGLAALRPVMGRQDAEATVTAGNASGQNDGAAACLVTTPEFAAEHGLRPLARVVSTAIAGVPPHLMGIGPVPATRRALEAAGLTLADMDLIELNEAFAAQALAVTREWGLAPGDFERLNVNGSGISLGHPVGATGARIVATLLHEMERREVRYGLETLCIGGGQGIAAIFERVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBB6</accession>
    <name>A0A1H6EBB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000062">
        <property type="protein sequence ID" value="SEG95047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95047">
        <property type="protein sequence ID" value="SEG95047"/>
        <property type="gene ID" value="SAMN04489712_1622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG95047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="22031" checksum="0E6C82567C2F3C26" modified="2017-01-18" version="1">MSSDDTTDGRPKLGQEPIQPKGADLSFLNPRNRTAAADRQAPADAAETPPAANDGPPPASPRSQDDHVQSDDHVQGRAEDGSDGQAAKPVIVYIPSRLRTKLKKAAAGSGRTYTDVLFDAVDALDAHLPDLFKGHPAAPSPGSLFSRRSVRGRPTSTRPAPNVQVPIRPPTIADLQVLDDRANRYTAGNRSEFVRVVLSAYLSGKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S0D4</accession>
    <name>A0A1H5S0D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WXG100 protein secretion system (Wss), protein YukD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44035">
        <property type="protein sequence ID" value="SEF44035"/>
        <property type="gene ID" value="SAMN04489712_10128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF44035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="441" mass="44553" checksum="CB0E912BC43AC624" modified="2017-01-18" version="1">MAAWSRVTLIGEQRRIDTVLPALEPIGALMPDVLRLLGDPVHSPPRLRHLVTSTGEVLDPGATLADRRIPDGAVLRLVHSDEPLPAPVVHEVPEVVGDALDGRLWRWSPAAARWSATFAFVALTFAVGLVAGGALPVGAAPGALGGLGALLVAGGVALGVSGREPLGTALTLGGGTVGMLATWSAAGSHDWAEWARWGGPALLAAVLVALLGISSPLGRGGLIGGGVAALLTLEGTLCAALGLNAARTGAVLAVTCVIVLNLLLRAALMLSGLTSLDDRRGAGASVARGDVMAALDDAHRGMTIGTVAVAVAAAVAGLGATAAFDGWNAALAGLLALVVGSRARMFPLVLEKAALLAATVAIVVTLAVRWAEHTAWGAAPALGMLLAGLVIPAVVLASEQPEHVRARLRRSMNRIEAVAVVALVPVAFGTFGTFTRLLGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SSX4</accession>
    <name>A0A1H5SSX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SAMN04489712_101352</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53712">
        <property type="protein sequence ID" value="SEF53712"/>
        <property type="gene ID" value="SAMN04489712_101352"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="3"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="16">
        <location>
            <begin position="354"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SEF53712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="476" mass="50884" checksum="FA268CB690B4DF45" modified="2017-01-18" version="1">MTRRAKIVSTIGPACSSDEQIHALVEAGIDVARLNMSHGDHADHEAVYHRLRAASDATGHGVGILADLQGPKIRIGRFAEGPVRLTLDDEFTITTDDVPGTRKEVSTSYQGLPGDVAPGDTILIDDGRVALEVTDVDGPRVRTRVAVGGMVSDNKGLNLPGVAVSVPALTEKDEHDLRWALRLGVDMIALSFVRTPADAEICYRVMEEEGVRVPLIAKIEKPQAVDALPEIVAAFDGIMVARGDLGVELPLEQVPIVQKRAIELCREKARPVIVATQMLESMISAPRPTRAEASDVANAIFEGADAVMLSGETSVGQYPIESVQTMSRIALAAERASLRAVHSLERMPETVGGAIARAAAEVGAIVGAKALVAFTMSGETARRLSRYRSPIPLLAFTTLQATRSQLALVWGVETFIVPHVDHTDDMVRQVEQSLLEIGRCQKGDRVVIVAGSPPGTPGSTNALRVHRIGDAIAIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TDJ8</accession>
    <name>A0A1H5TDJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60248">
        <property type="protein sequence ID" value="SEF60248"/>
        <property type="gene ID" value="SAMN04489712_101558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="75"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF60248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="28256" checksum="6A060CD267A45C81" modified="2017-01-18" version="1">MSVDEQETGPSRSGIARALAVIDAVARSPQPLGVSRIARETGLSKAVAHRILRELVSGRFLGFDEKTKVYRLGAGALNIGLAAMRELDVPAVAHRHLVALAERTGQTATLSLRQGWSRVYVDQVLSPHEIRMSVALGSGHPLHAGSSSKAILAALPDAEVADYIAHHRLDGVTDATITSAEALRQEIARIRRLGYAASAGERQSGAASVAAAIHGAIGQVVGSISVCGPQDMLTRSRREALGAQVQVAAAAISTDLGFRPDDETAEEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TKE2</accession>
    <name>A0A1H5TKE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62658">
        <property type="protein sequence ID" value="SEF62658"/>
        <property type="gene ID" value="SAMN04489712_101635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF62658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="30040" checksum="57DDD6FC8A14D375" modified="2017-01-18" version="1">MPLVPASGDPVLQIKDVDLVRDRRLLLEQVSLRVQPGEHWALLGPNGAGKSTLLSILGAYRHPTRGTAEILGQLLGRVDVHRLRGLIGQVNPHHPVQSQSRTVHQVVLTGATGTTEPVPRWTPTPAELDRAAELMALMGLERLRDARWANLSHGERGRTLIARALMPSPRLLLLDEPATGLDVAARERLLESIDGLRERHPDMASILVTHHLEELPASTGHAMLLRAGRVLASGAVDDVLTTENVSACFDHPIAIHRRAGRWTATAGRVPQRPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TRE0</accession>
    <name>A0A1H5TRE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65344">
        <property type="protein sequence ID" value="SEF65344"/>
        <property type="gene ID" value="SAMN04489712_101718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF65344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="27811" checksum="5C5D4A43966ACCA6" modified="2017-01-18" version="1">MEIIGNGFLAHHLQPLRDAHPGYLVLAAGVPRQQLPDRDHRREVALVDDMIRRGLRQRRTLVFFSTASMYGAPGCRGLEDDPIVPSTRYGAHKRDLELRIRESGVDHLILRLGYVLGPNGPDFRLVPALMKQILSGRVRILRGARRDMLHVSDFVAVLDGLLGAGVANDILNVASGDCAEILHVVEHIERRLRLFPEHQIVEGSHVSHCPSVDKLRAVLPAFGEMGLGPGYHRHALNRYLAETGHLDRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U157</accession>
    <name>A0A1H5U157_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68805">
        <property type="protein sequence ID" value="SEF68805"/>
        <property type="gene ID" value="SAMN04489712_101829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009285631" evidence="3">
        <location>
            <begin position="29"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="47"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF68805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="409" mass="42957" checksum="CD9859A43CA64F67" modified="2017-01-18" version="1">MSAKTGYKVTALLGAALLLTACASKEERAGVTQQSSGGGWSAGRPVVKVGLIGPMTGPFAVAGISLENSVKVEIDRLNAAGGLGGAKLELVVRDSGLDPAKAVQAANEFAGDDSVGLVVGPALTAFYNAAKAGFESNKKINCQPMVATGDFSSLKYGFRAQDPVSLDAAKMIAHLKTEGVTSIGVVYEGDDAGKNTADEVKAQAEAAGLTWKGFEATRPDDQSHRPYIDKLKDAGAIWISNSSSGAKTMAAANEAGYKGLIVGGSGARNISFVEAAGDAADGALFSATYYPYPSRDGRDTWKQGYRRHIEEIEKRFGKNTGPKTGAESPKAAEIAADCVFAYTQAAEQAKSLDPDAVAAALEKIEIPDTETPSGNSIKIEKHEFFNLDDIHVYQWKKDDKGWHTVEVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UY95</accession>
    <name>A0A1H5UY95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein involved in the export of O-antigen and teichoic acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79944">
        <property type="protein sequence ID" value="SEF79944"/>
        <property type="gene ID" value="SAMN04489712_10284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF79944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="452" mass="47800" checksum="E9B0BB6E9FE5CC4B" modified="2017-01-18" version="1">MRAVARAGLKGGRNPVQAVISGVRGDMADPLFRNAYALVANGAFTGMLGLAYWTLGALLYHDDPAAVGRNWATIQAIMFVGGVTMLNFLLIRFVPQTAGGTGRLVLACYGIGAAAALLLALAFLLVVPSRAPVYGHLDGWTAGTWFLLLAVGWNLFNQQEAVFTGLRHATWVPVVNLTFGVAKLALLALLALTLHPQNGIVLSWFVPMLVALVPVNAFLFGRLIPRHRERGHGRGDRTTCREIVRYFGGGYLGGIFQYASISLIPVVVTSRLHDDALNAYFQMAWALGMMLELLAMTLSLSLTVEGAFDPSALAASTRAALRRTFMLMLPAVVLAVVACPVALKLLGPGYAAQGAPLLQLLAIAVLPKAVIELYVGVLRVRSQTRLIATVQGVRLLGVLALVPLLFHGTRLTTIGMVVLGVNLMVAVAILPALRRACAPGASGAPVMAGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UZK8</accession>
    <name>A0A1H5UZK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal peptide peptidase A. Serine peptidase. MEROPS family S49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80404">
        <property type="protein sequence ID" value="SEF80404"/>
        <property type="gene ID" value="SAMN04489712_10299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004634">
        <property type="entry name" value="Pept_S49_pIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001217">
        <property type="entry name" value="Protease_4_SppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00705">
        <property type="entry name" value="SppA_67K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S49" evidence="4">
        <location>
            <begin position="97"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="4">
        <location>
            <begin position="358"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF80404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="571" mass="60682" checksum="7CFA83734BDD7BC9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VAC3</accession>
    <name>A0A1H5VAC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84312">
        <property type="protein sequence ID" value="SEF84312"/>
        <property type="gene ID" value="SAMN04489712_102239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF84312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="21760" checksum="BD614021047797E1" modified="2017-01-18" version="1">MTTRFTAVLAMPPPGRAAPPGVDPDELRLAMLEDVYEVVAGLELVTPALVLHPPHQPDAEAVTWPGTPILREPDPAAALQAMADLGAEEAALVVPDAPDLPPLLIGKLFRALGSAPAAACPATGGGLVALAVRLPVPGWLAEALPALGAALDAPDALARLRTAAPGAGLVRKTPGWHRLRDPADLGLLDPGLEGWENTRALLASHPLPAPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VCP0</accession>
    <name>A0A1H5VCP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84227">
        <property type="protein sequence ID" value="SEF84227"/>
        <property type="gene ID" value="SAMN04489712_102236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF84227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="467" mass="49436" checksum="380671B5A4076BE9" modified="2017-01-18" version="1">MSDLPFGFNRPGDEGDDSSSGRPQDPFSAMGGDMRQFADMLRSFADMIQSSGPGAGPAGSSGPLNWDLARNIARHTVAEQGDPSVVDAERRQVTEALRLADLWLDERTTLPAGIRTPQAWSRSEWIERTLPVWSQICDPIATRMVESMGGALGGGLGGPIPDEMQAMAGPLIGMVKQMAGAMVGGQAGQALGALAREVVGSSDIGLPLAPDGVGALLPTGVAAFGEGLELSTEEVRLYLALREAAHQRLFAHVPWLRAYVLGAVEDYARGITVDLSGIEQAVAGLDLSDPEALQRALGGEISLQPEETPQQKAALVRLETALALVEGWVDTVVNEAAEGRLPGAVKLAEAVRRRRATGGPAERTFATLVGLELRPRRLREAGVLWRALTQARGVEGRDAVWGHPDLMPTAADLDDPDGFVHGRPESELSDLDLSKLTDGLDERDEGTGTSGKPDDDDPGTERPSEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VFY6</accession>
    <name>A0A1H5VFY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85728">
        <property type="protein sequence ID" value="SEF85728"/>
        <property type="gene ID" value="SAMN04489712_102291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF85728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="23070" checksum="E17BBDEB8EDE44AA" modified="2017-01-18" version="1">MSEGNGRAAAGQERPWELTEPVRPERKGERTRQRILEAARRQFARVGYERATIRRIAADAEVDKASVMKYFGTKQELFRQAVHFRIPLDRLTTDDPGRTAENYLRGLLTTWAADPDSPMAVLLRTSMTSEEAAEVLRARVTAEVVDLVAAADPAPDARLRAAVFAALMMGIASQRYLLRMPDLAEAELDDVLRVAAPLIRQLISPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VWR9</accession>
    <name>A0A1H5VWR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_102485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91426">
        <property type="protein sequence ID" value="SEF91426"/>
        <property type="gene ID" value="SAMN04489712_102485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="22"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF91426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="29478" checksum="851ACF5719852CA8" modified="2017-01-18" version="1">MTAVMSRPPGAVRIGLRRGLLELRLYFREREAVVFTFLMPVMLLSIFGAIFQGELGDTGVDYRQYFTAGMIASGMMSVTFVGLGVAIATERDDGTLKRLYGTPMPRSSYFIGKTLLALTLSLLETAVLFAIGATLYGVEPPADPGRWFTLGWVFVLGVAACSLLGIAMSSLPRTGRSAPAVLNLPFLALQFTSGVFVLFDSLPGWLQQVAAIFPLKWMCQGLRSALLPDTMLAMEPAGAWEHGRIALILGGWCAAGLVLCVLTFRWKGRQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WD73</accession>
    <name>A0A1H5WD73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97529">
        <property type="protein sequence ID" value="SEF97529"/>
        <property type="gene ID" value="SAMN04489712_102681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009288144" evidence="7">
        <location>
            <begin position="25"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF97529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="316" mass="33413" checksum="5B0C2E75E113852C" modified="2017-01-18" version="1">MFSKQRVMSAARALLVLLAVAFCAYSLVSQWEETREAFARMSWAAIVGAFLAGVGGLVAWMLGWRVFLAGLGSPLPLTAASRLSFISGLGKYVPGKVWALVTQMELGRQYDIPRIRNVSSSLLAIASTTASGLAVAAVTLPLTSPAATEDYWWLFLLAPVLMACLHPRIVTWGIDLLLRLVRRPPLEHPVSLAVTLRAVAWTVVGWALFGVHTWLIANAAGGDGRGLPFLATGAYALAFTAGFLVFIAPNGLGAREAVIVITLSPVLPAGAPLVVALVSRVLLSLADLTCAAAAFAMGRRAGMNRPPTDLTPIGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WDQ9</accession>
    <name>A0A1H5WDQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97510">
        <property type="protein sequence ID" value="SEF97510"/>
        <property type="gene ID" value="SAMN04489712_102680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF97510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="25394" checksum="0F0621A96D1EE3A5" modified="2017-01-18" version="1">MKLADAVAFVGHQVHICRFREAGTLLRWMGGDLRGKKVLDVAGGDGYWAGQARRRGAHAVSIDIARGKMEYGKTLAHSPALIEGDALALPFADGAFDAVLSVCAIEHFDDGGRSLAEMARVLRPGGEIFMSADVLSRADAWPKLRDAHKAKYHVQHTYTHESLGGLMDEHGLDVVGYSYQFRTAAAERLYLSLSAYGGRVGFNAAAPLAPLVALADRRAPNDRGSIVLVRARKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X7E5</accession>
    <name>A0A1H5X7E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NitT/TauT family transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07669">
        <property type="protein sequence ID" value="SEG07669"/>
        <property type="gene ID" value="SAMN04489712_103122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG07669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="28807" checksum="3B00995B187AB880" modified="2017-01-18" version="1">MTTQTVSPRSPRAARPLTRTGRWARGAVGVAALFAASELLGRAEVVDRSYLPPASEIVTRAVELVGDTLFLQYLLDTLTAWAVGLGLAIAIAVPLGLLLGSVPAVNTATRAIVEFLRPIPSVALIPLAGLLLGSGLNMKVALIVYAASWPILFNTMYGLDEVDPAAKETLRVFGFGRAEILLRVSLPSAAPFIATGIRLAAAIALILAVGTEIIAGFGEGLGIFIAQAYSMPDGARDVLAGTVWAGTLGLAIDAGLGQTQRRMFRWHHARQGGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XEN1</accession>
    <name>A0A1H5XEN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10103">
        <property type="protein sequence ID" value="SEG10103"/>
        <property type="gene ID" value="SAMN04489712_103217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289355" evidence="2">
        <location>
            <begin position="41"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG10103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="23939" checksum="03DE9EA47547CC03" modified="2017-01-18" version="1">MTSRPSAGRPAARMAAGALPVVLPVMLAGTLLAGCAGQEAAGGASVPPPTSRAVPTWDGRAVPSAAPAATPLVFAPPLPRSVPVSITIPRLGVSAPVSRLGLRRDGTIEEPPLSEPNLTGWYEEGPTPGEAGPSVILGHVDANRRAAVFHRLGELRPGDRIEVTRRDGSVAVFAVQRLVRVAKDRFPGELIYAEDIDYSALRLVTCGGAFDSRSGHYVDNVIAFTRLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XHB3</accession>
    <name>A0A1H5XHB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphopantetheine attachment site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10757">
        <property type="protein sequence ID" value="SEG10757"/>
        <property type="gene ID" value="SAMN04489712_103240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG10757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="91" mass="9952" checksum="50D37D907B9F3895" modified="2017-01-18" version="1">MSRTTPDDDAREPAGPDAQQALAGLWRQVLRVPRVGRTDNFFALGGTSLIAARVRRAIERELAVAIPLRTLFEAADLAGLAARVTDARERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XI07</accession>
    <name>A0A1H5XI07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_103265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11388">
        <property type="protein sequence ID" value="SEG11388"/>
        <property type="gene ID" value="SAMN04489712_103265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG11388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="237" mass="26514" checksum="024E1D57BB7FE221" modified="2017-01-18" version="1">MTSAQAEPPTPPWRRPRKGAPARRPLSRDLIVRTAQDILRTEGLDGVSMRRVAQELGTGPASLYAHVSDKDELLELVVDRIAGEIPLLEPDPARWQEQLKEAARAARRVWTTYSDVSRISLGSVPTGENQLRIAENHLAIMRAGGVPDQVAAWFVDRMGLYVDADAFEGSVFAARFREGWDAGEYFGQIRRYYEGLSPERFPHITSLVGELMEGEDEERFEFGLDLMVRGLASYVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YI93</accession>
    <name>A0A1H5YI93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23420">
        <property type="protein sequence ID" value="SEG23420"/>
        <property type="gene ID" value="SAMN04489712_10412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="15"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="14858" checksum="5DF858CB3A7CDDD7" modified="2017-01-18" version="1">MQQTTGDALKRRLLASPAAVGLARTYVGAHLRRLGYPDAIEDAQLIAAELVTNAARASGPWDTVVLFLGEQSRGLVLAVWDGAAGTPSPGPLPVVDLNDVDALPDDPGGWGLHIVRALSREVWMERPGTGPGKWVCASLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YJC5</accession>
    <name>A0A1H5YJC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24211">
        <property type="protein sequence ID" value="SEG24211"/>
        <property type="gene ID" value="SAMN04489712_10447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG24211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7349" checksum="F7A5E9B641E181C9" modified="2017-01-18" version="1">MKQQQVGATFTTNQRWGLDHIHNAAITPAEPDRPPSTDRSGIDGFLLTFGDDQAATLRTDPNRNLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YPW1</accession>
    <name>A0A1H5YPW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25810">
        <property type="protein sequence ID" value="SEG25810"/>
        <property type="gene ID" value="SAMN04489712_104108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG25810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="27967" checksum="DBD56A12EAD2C7DA" modified="2017-01-18" version="1">MRVLYDVDSDVPPSFYLVVPRATSGYTSGELPIREVVSGAREHSSPQAIAGLRQEIDRLDQFRADAALAGPGGIRMLLQAKFSSRSNATMLSRYGELTKIIAAFADCRGRMGFELPSLFEAETIPAPRPVPWSPLLETTSGSLAVKAIRRLPDLSRESLPSTLPNSSPRVELAIPQQVLHDVFAAFLRMLDDQLVRLRLLLFIALAALTRTACVAAFVLVLIAVCLRYGLRHEPSDDDERFLLRTPELIRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YW51</accession>
    <name>A0A1H5YW51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase/uncharacterized protein, coenzyme F420 biosynthesis associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27707">
        <property type="protein sequence ID" value="SEG27707"/>
        <property type="gene ID" value="SAMN04489712_104191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG27707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="382" mass="41951" checksum="15D27B4B94082BBC" modified="2017-01-18" version="1">MSAQMIDWNVAVQTGTRLVRPGPQISQEEAYEVVDELRRLARLAEGHVRDFTGIEAVGTEATQATIVDRPGWIRANVDGFRVVLEPLMDRLAERRGGLGGGPGGAVIQAVGSRVTGVQMGALLAYMASRVLGQYELFLPPDPSGNAPTGRLTLVAPNIVHVEQELGVDTRDFRLWVCLHEETHRAQFTGVPWLRSYVQDQMTEFLLASDVDPAAMMERLRQTAEAVVDAIRGGDEDPDNPRPGLIDAIQTPQQREILDRLTAVMTLVEGHGDYVMDAVGPEVVPSVKEIRARFQGRRDGGSRLDKAIRRLLGIDLKMRQYAEGSRFVRRTVAEVGMEGFNKVWTSPETLPTHAEIKEPTAWIARVVGTRSLQAAPPPEAGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YX36</accession>
    <name>A0A1H5YX36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol-1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28594">
        <property type="protein sequence ID" value="SEG28594"/>
        <property type="gene ID" value="SAMN04489712_104229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="PTHR11510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="218"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG28594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="384" mass="40751" checksum="A53904B803E5F724" modified="2017-01-18" version="1">MRVGVWLVGARGSVATTVVVGAAAIRSGLMPPVGCVTETPDFAGAELPPLDALVFGGHDIADVPLVKRAEKLARDGVVPPLLPAAVTGELDEAEGEIREGLGGGSDAGTLRERADRLIGDLVSFRDRRELDRVVVINVASTEPPFERRPEHAGLEALERAMAEPGEVLPASSVYAYAALRAGCPYIDFTPSTGARLPALDELARRMGVPYGGSDAKTGETLVKTALAPMFAARALAVRSWSGTNLLGGGDGATLADPAAGESKKVSKDRALSEILDRRVEGQTHIDYVPHMGEWKTAWDHVMFEGFLGVRMTLQFTWQGCDSALAAPLVLDLARLTARAHQAGRFGPLPELGFFFKDPIGSSEHRLTAQYELLRAWAVELGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZY9</accession>
    <name>A0A1H5YZY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28925">
        <property type="protein sequence ID" value="SEG28925"/>
        <property type="gene ID" value="SAMN04489712_104244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG28925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="26549" checksum="E4916943C6648BB4" modified="2017-01-18" version="1">MMNSTAADPPPTAVSVRDLRVRRGGRDVLRGIGFDVPRGSVVGLLGPSGCGKTTLIRAIVGVQIVRGGTVTVLGRPAGHPELRRLVGYATQNPAVYTDITVTENLRYFASVLGAPRGDVRRVIDEVGLGRHRDQVAATLSGGQLSRLSLAVALLGRPELLVLDEPTVGLDPLLRQELWELFGELAAGGTTLLVSSHVMDEAARCRRLLLMREGAILADDAPDALRARTGADDLEEVFLRLISQHVEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z7V6</accession>
    <name>A0A1H5Z7V6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">SAMN04489712_104418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32609">
        <property type="protein sequence ID" value="SEG32609"/>
        <property type="gene ID" value="SAMN04489712_104418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="95"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG32609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="21534" checksum="1B60E83583080F8C" modified="2017-01-18" version="1">MTETTTERPVPQPRLKLRYREEITKSLQEQFGYANVMQIPGLVKIVVNMGVGEAARDAKLIEGAIRDLSLITGQKPSVNRAKKSIAQFKLREGMPIGAHVTLRGDRMWEFLDRLLSLALPRIRDFRGLSPKQFDGNGNYTFGLTEQVMFHEVDPDKVDRQRGMDITVVTSATTDDEGRALLRALGFPFKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z9A8</accession>
    <name>A0A1H5Z9A8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">SAMN04489712_104433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32948">
        <property type="protein sequence ID" value="SEG32948"/>
        <property type="gene ID" value="SAMN04489712_104433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG32948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="37" mass="4414" checksum="C925659F5BFEE26F" modified="2017-01-18" version="1">MKVKPSVKKICNKCRVIRRHGRVMVICQDPRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZB32</accession>
    <name>A0A1H5ZB32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33733">
        <property type="protein sequence ID" value="SEG33733"/>
        <property type="gene ID" value="SAMN04489712_104468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="2">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG33733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="23463" checksum="4EFBD9AD547A7C17" modified="2017-01-18" version="1">MLVLAFDTATAAVTVALYEWIPGAGVRPRAAADAVDARRHAEVLTPAIAGVLAEAGAVPADLSAVAVGVGPGPYTGLRVGLMTARALGEALKIPVHGICSLDAIAWASARDEPFVVATDARRKEVYWARYESARVRTTGPAVSPPAEVLAELGVGPGELPVIGEGAALYPAQLGAAADPLPLLPSAAALAELAVTRLSGADGLPLLPPEPLYLRRPDARAPGPRKKVSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZCR6</accession>
    <name>A0A1H5ZCR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34303">
        <property type="protein sequence ID" value="SEG34303"/>
        <property type="gene ID" value="SAMN04489712_104493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="216"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="412" mass="45410" checksum="099A34A3DCBA946C" modified="2017-01-18" version="1">MKVTYVLMHAYGMGGTIRTVINQANAMAEAGHEVAIASVVRRRDRPRFPVDGRVRMITIADHRGRPAPPPPRGGRLGRWLRRHWTVPVAPGEEPGSEVPVGEAAKRTFTREVEEGFIEYVRGLREGVLVTTRPALNLLSARYAPQELVRVAQDHMHLTSYKPAVHAAILADYPRLDAVVSLTRQDEEDYRRAMGDRVRIAQIPNPLHSLDVPRTDHSAKVVVAAGRLTRQKGFDLLIEAFGQVAAQYPDWTLRIYGGGPWEGRLRGQIRRRRLGDHVLLMGTVKGFDRELAQASIYALSSRFEGFAMVMLEALNCGLPVVGFDCPTGPREVIRDGENGLLVPPEDPDALAAALCRLIGDRRLRRRLGTAAIGTAAGYGPVPIRHRWEALFAELLRAKSAGPDGRPTGTSLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZXJ8</accession>
    <name>A0A1H5ZXJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phytoene desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40186">
        <property type="protein sequence ID" value="SEG40186"/>
        <property type="gene ID" value="SAMN04489712_10520"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG40186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="489" mass="52417" checksum="63CA9B9BB815FD89" modified="2017-01-18" version="1">MGAGDPIVVVGAGLGGLSAAVHLAARGREVVVVEARDGPGGCCGTAHLGPYRFDTGPSVLTMPGVLAEVFGAAGEELHHVLPLRRLDPFYRLTFHDGTHLDVVAGAEEMAEQVRALCGPAEATRYLRFRERLGAMYAAEWPAFIDADMTRLRAVARPYALLKLAMAGGFRRLDRLVGAHLTDERLIRAHTFQALYVGLPPYAALGIYAVIAHMDTVGGVYFPRDGGMHAIPRVMAAVAEKAGAAVRYGVRATKVETNTSGVAAVRLDTGERLAAGHVVVACDLPRAHDGLLPEAAADWRLRRPRYSPSCLLVHFGLDRRPAERAHHTLHFGREWRATFSALTAGRPQPDPNLLVTCPQTDGTAASPGHPTLSVLEPAPNLTGGTDWETLTPRLERRLLSRLADLGYGDLSGAPRMVLDPPAWARRGHSAGTPFALDHRLRQTAWLRPSGRARRVPGLHFAGMYTAPGVGVPPVLISGRLAAARILEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A045</accession>
    <name>A0A1H6A045_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted O-methyltransferase YrrM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42099">
        <property type="protein sequence ID" value="SEG42099"/>
        <property type="gene ID" value="SAMN04489712_105117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG42099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="21625" checksum="437ADB58BFA61C78" modified="2017-01-18" version="1">MEDYLPEDEALLDARRLGEEVGAVPIGPAGGAALRFLAAVLDARTVVEIGSGCGVSGIWLLRGMRPDGVLTSVDLELANQRLAKEAYTAAGFSSSRTRMIVGRALDVLPRLTDGAYDMVFCDAAKEEYPEYLAAALRLLRPGGVVAFDNALWHDRVADPNRRDPETLAIREVGRLIREDERLVPLLLPVGDGLLCALKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A047</accession>
    <name>A0A1H6A047_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="10" type="ORF">SAMN04489712_105119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42143">
        <property type="protein sequence ID" value="SEG42143"/>
        <property type="gene ID" value="SAMN04489712_105119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="331"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG42143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="485" mass="49874" checksum="BE6D195AAA696CBA" modified="2017-01-18" version="1">MPIHTRIRTEPDARPVGRVALDNGAELVAVPVRPGPEVHGADLGVAPPLDPADLLAFHDAKGEPGEVVACPLRLGDGTGELLLYGVGDGSPGALRRAGAALARRAKGRDGLVVLAPEGDAAAFAEGALLGSYEFWIGEAPRRRSVGTITVLGADRAAVERGTVIAEAAALARDLANTPSVDKSPAWLADRAAELAERSGLGVRIRDEGALREEGFGGLIAVGAGSVRPPRLIELTYEPEGGADRHLVLVGKGITFDSGGLSLKPNDNMKTMKTDMAAGGVVMAVLAALPALGVRARVTGLVAAAENMPSGSAMRPSDVITHYGGRTSEVLNTDAEGRLVLADALAYADAVLEPDAVVDVATLTGAAKVALGLRHAALFATDDALAEGLTGAGTAAGEPVWRMPLVDDYRVAIESEVADVANIERRGFGGGAIMAALFLREFAGKRPWAHLDVAGPGRATADDAEITKGATGYGARLLLNWLIAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A5S1</accession>
    <name>A0A1H6A5S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43534">
        <property type="protein sequence ID" value="SEG43534"/>
        <property type="gene ID" value="SAMN04489712_105202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG43534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="91" mass="9866" checksum="A4AEECBC7C2603FD" modified="2017-01-18" version="1">MKMLIPAYVYTATLLRDGAEKSTLFVKGRVERARQRDDRGIALSAEMVGLIAVVVAIALVLIQADIGKWILNMIDEQLQKLKGAKPAEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9C9</accession>
    <name>A0A1H6A9C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44657">
        <property type="protein sequence ID" value="SEG44657"/>
        <property type="gene ID" value="SAMN04489712_105263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="75" mass="8260" checksum="A6A1A74CE709BA9F" modified="2017-01-18" version="1">MTDDPTPMSAVPELLALAAKTRHDIDQRDLEGAISDAITRRGWPWTLAHTAGMLARGEQVRDLRNAIGPIGRKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AI39</accession>
    <name>A0A1H6AI39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="9">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">metG</name>
        <name evidence="13" type="ORF">SAMN04489712_105420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47426">
        <property type="protein sequence ID" value="SEG47426"/>
        <property type="gene ID" value="SAMN04489712_105420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="11">
        <location>
            <begin position="12"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="12">
        <location>
            <begin position="429"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="355"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG47426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="600" mass="67331" checksum="CAA54666D9AF9E2A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXI1</accession>
    <name>A0A1H6AXI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53092">
        <property type="protein sequence ID" value="SEG53092"/>
        <property type="gene ID" value="SAMN04489712_10672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="368" mass="40543" checksum="E5EBF439AC112D2D" modified="2017-01-18" version="1">MVDENALRFVVVRPPVLDESRGRVIVDTETADAVLGRIQAKRSARAEVTWADAAAAVGAEIVSDAAYWPDSPSFSVLGFDTGYVRELLEWARDNPDDPASFLPQAQRWLDRATPSRGDVREWVAGREYRAARDSAWLSWYGFVLHQDRRPQQAPGLAGSLVFLELLGAAVGDRDRFRRTAVASRTEGPAVRPDVLLGPRPVATAPDTTASDAAAPEGARSRQAAAESDERIDPWLIENIRNLRDARTAVQAFFDAKLGRQRAVTYYVTSVDSTEPNGPVGFEGIEQSAPWRVTQAELDADEGLAEALRQADFDLARDTLPEALERIDASLADLTQRLYARRRDTRVTVADGRHVRVVTNSRPTTDRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B191</accession>
    <name>A0A1H6B191_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54372">
        <property type="protein sequence ID" value="SEG54372"/>
        <property type="gene ID" value="SAMN04489712_106153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="157"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG54372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="460" mass="51237" checksum="061A0FB8A78B8909" modified="2017-01-18" version="1">MSTPPKRIFLNAFDMSCVGHQAPGLWRHPDDQAYRYTDLDYWIELARLLERGRFDSLFLADVLGAYDVYTGSRDPALRQSTQIPLTDPLLVVSAMAAATRHLGFGVTVSLTYEQPYALARKFTTLDHLTKGRIAWNVVTSYLDSAARNLGLERQLDHDDRYAVAEEFLEVCYKLWEGSWEEDAVVRDVQRGVYTDPAKVHDIGHKGRYFQVPGAFLSEPSPQRTPVIYQAGASAPGRAFAARHAEGVFINAVTKEGLRRRVADIRGRAAREGRDPDSVKIFILFTAITAPTDAEARAKYDDYLRHSSYEGAMALYGGWSGLDLSEYDPDEPLEYVRTDAVHSALEIFTTIDPDRRWTPRDIAEYLAVGGIGPVVAGSPATVADELESWVEETGIDGFNLAYAVTPGTFVDFVDLVVPELRRRGRVPEEYAGSTLRENLLGTGVRRLREDHPGAGYRGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6C8</accession>
    <name>A0A1H6B6C8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiD</name>
        <name evidence="6" type="ORF">SAMN04489712_106258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CbiD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55777">
        <property type="protein sequence ID" value="SEG55777"/>
        <property type="gene ID" value="SAMN04489712_106258"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043780">
        <property type="term" value="F:cobalt-precorrin-5B C1-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG55777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="42333" checksum="671A8F14C1B84CD6" modified="2017-01-18" version="1">MTPEEPRLREPDLPRTMKVRQRALRTGWTTGSCASAAAKAATSLLRTGRRPDHVEIALPSGNRVTFRVEDCDLDTARGRARAVVVKDAGDDPDVTHGARVTADVSWLDGPGVELDGGEGVGVVTKPGLGLELGGPAINPVPRRMITHAVAEALTGDALEQAPPAPADPGTGRGVRVVISVPDGERMARKTTNKRLGILGGISILGTTGIVRPFSTASWRASVEQAVSVMAAQGESTLVLCTGGRTEKGAMKMLPKLPEVCFVEVGDFTGAALRRAVGHGLRQVVFVGMVGKLTKLASGVLMTHYTRSRVSTELLSGITTDMGGTPELAAEVARANTARHAYELWENAGLLGRCGRELCRRTADVLERFAVEEAGGELAVQVVMVDFTGERMVAMYGRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B870</accession>
    <name>A0A1H6B870_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56407">
        <property type="protein sequence ID" value="SEG56407"/>
        <property type="gene ID" value="SAMN04489712_106310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG56407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="29967" checksum="BB5D0645FD41C9D5" modified="2017-01-18" version="1">MALSAAPRPSAGAPEFSLSRPNVARMCNYLLNGKDNFEADRLAADDVLRRAPEMLTLVRANRDFLTRAIRRLTEGPGIGQFLDLGTGMPMSPSVHEIAARFHPSPRVAYVDNDSVAVAHARALLDNGDTVVAVDGDLREPERILADPRLTSVIDFERPVAVLLSAVLHFVTDEEGAARIVGALRDALAPGSALVISHACLDHADPQVLADVAEVYTRTGLPLVPRSRARIGEFFTGFELIDPGLTDVAHWPLTTGPRPRPALTFYGGVAGYPARHRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B8F6</accession>
    <name>A0A1H6B8F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56695">
        <property type="protein sequence ID" value="SEG56695"/>
        <property type="gene ID" value="SAMN04489712_106330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG56695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="14281" checksum="AA7B6A984F4FF5C5" modified="2017-01-18" version="1">MIRDGYLVRWRGREYEAGPGADGEIRLYTTEPADGFEEIRPGRHRRVVPPDEVEGIRYVRTVCTWRGEPFIVVGEHDNWLRVEYAGGRAQVAERLQLDRIDHGVWQAWASRAEVEDLREEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BE86</accession>
    <name>A0A1H6BE86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58635">
        <property type="protein sequence ID" value="SEG58635"/>
        <property type="gene ID" value="SAMN04489712_1077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG58635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="39" mass="4380" checksum="5779F5A25AB88741" modified="2017-01-18" version="1">MLVHSKTRTARPRSEPAVRVDVRNQVSRTKCAPVALGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BHV4</accession>
    <name>A0A1H6BHV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_107123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60321">
        <property type="protein sequence ID" value="SEG60321"/>
        <property type="gene ID" value="SAMN04489712_107123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG60321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="30369" checksum="5359520E98FFA696" modified="2017-01-18" version="1">MIDLLRYDFMRIALVLAVLIGLTAPAVGTFIVQRRLALLGDGIGHIALTGIGLGLLTSTSPVLGALVVSVLGAVAIEVLRARSRTGGDVALALLFYGGLAGGVLLTNLRGGGSGLQSYLFGSITSVTVEDLYVVAALAAAVLAIVALFGRELFLLCQDEEVARASGLPARALSLLIAVTAAVTVVIAMRAIGLLLVSALMVVPVAAAQQLTRGFRDTMLTAMGIGVLSAVSGLVGSFEYDLPPGPSIVLLALAVYLLLVLWRTIGDSVIRRDRRSRTLPSSPKEATADAEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BIH3</accession>
    <name>A0A1H6BIH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Urea transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_107136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60513">
        <property type="protein sequence ID" value="SEG60513"/>
        <property type="gene ID" value="SAMN04489712_107136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017779">
        <property type="entry name" value="ABC_UrtB_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03409">
        <property type="entry name" value="urea_trans_UrtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG60513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="292" mass="30753" checksum="F89017595B67B4EE" modified="2017-01-18" version="1">MESLLNQLPIGLSIGAVLLLIALGLTFTFGQMGVINMAHGEFIMAGAYTAYMLQDWAGAQAAAVALPVAFALAGTMGWVLERTAIRHFYGRPLDTLLLTWGVSLVLQQAARDLFGAPNVQVVAPSWLNGGVTIGGGTLPYNRLFIMALAIACVAGIWAYQNRSAQGRRMRAVMQNRELAACSGVATARVDQLTFFIGSGLAGVAGVALTLIGPVGPSIGTYYIVDAFLVVVAGGLGQLRGAVIAALALGMLNSFAEFWTNASLAKVIVFAAIIVFLQFRPQGMFVLRSRALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJC4</accession>
    <name>A0A1H6BJC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Urea ABC transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_107135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60495">
        <property type="protein sequence ID" value="SEG60495"/>
        <property type="gene ID" value="SAMN04489712_107135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017778">
        <property type="entry name" value="ABC_transptr_urea_perm_UrtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482:SF4">
        <property type="entry name" value="PTHR30482:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03408">
        <property type="entry name" value="urea_trans_UrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG60495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="364" mass="38165" checksum="801FFFDE33899335" modified="2017-01-18" version="1">MSERVRGYALFATVALLLLVVAPLALPAFRLDELAKYLCLAIAALGIGLAWGQGGMLTLGQGVFFGLGGYAMGMYLKLHDAGGDLPDFMVWSGVERLPALWQPFGNPVVALAAVVLVPVAVAVLLGALVFRRRVRGAYFAILSQALAAAFVILLVGQQGLTGGTNGLTNFYDFFGRDPEAESTQRTMYFVVAGVLGVLYLLARQLVGSRFGRLLVAVRDGEDRVRFLGYDPALVKTVTFAISAGMAGLAGALFVPVVGIISPSLLGVVPSLELVVAVAVGGRYALAGAILGAVVMNYAKTSFSEEWAGGWLYLQGALFILVMTLAPKGAVGLYQQARDALARRRGASAAAVEKPGVAVKEEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BN59</accession>
    <name>A0A1H6BN59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycine hydroxymethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_107275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62131">
        <property type="protein sequence ID" value="SEG62131"/>
        <property type="gene ID" value="SAMN04489712_107275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="5">
        <location>
            <begin position="56"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG62131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="445" mass="46392" checksum="F4362E4A45E7303B" modified="2017-01-18" version="1">MEQHDGTFPEIAPWASPVARARISQVAADLGGLWADLSAGGVVDAVEAALHGHARQFDDEGIVLYAGTNVMSEAARRVAEAPVGGRPSMGWPGEKYQAGLDRLDVLEVLTPALMARLVGARFAEVRSHSATMSNLAVYTALTEPGDTIAVLPERAGGHTSHHAVGAPGVRGLRVVDLPYDVDAYDVDLGALPGFLERERPRLVVIGASLLLFPHRVAAIAEAVSAAGAVLLYDASHMAGLVAAGRFQRPLAEGADLLTFSTYKSFGGPPGGVIATDDAALAEKVSDAVFPGLTANYDAARLAPLAVTAAEILDDGGTYADRCIAVARDFAAALSEEGFTVAGQGRGFTDSHHVAVDVAALGGGRAAMARLAEAGVYLSAIGLPWQADGEPDRGLRIGTQEVVRRGLGEPELRQVAALMADLLLRDADPATIRKAIARIREEARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNR8</accession>
    <name>A0A1H6BNR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62359">
        <property type="protein sequence ID" value="SEG62359"/>
        <property type="gene ID" value="SAMN04489712_107291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG62359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="26451" checksum="7DE11628182880B6" modified="2017-01-18" version="1">MAVALITGAADELGLAVARRLASEGHLVALSDLPRRERLETLHKLAAKLGGPGAALVVPADVADPEDVARMVAEVEERAGEPIGILVTVAGYLATAPFLRHDPDDWWRVVDTNLGGVFACAQAVLPGMAERGGGRMIFIASEWGVTGRAGATACSAAEAGIIAMAKSLGRELGQLGIAVNAIAPGVVDTSRLEADAREAGVTREVIRTRHAARVPLGRIAAPEEIAAAVAFLADPRMISMVGQVLHINGGTTRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BVI4</accession>
    <name>A0A1H6BVI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64731">
        <property type="protein sequence ID" value="SEG64731"/>
        <property type="gene ID" value="SAMN04489712_10850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="73"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG64731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="15857" checksum="C0AC65FA2AF59845" modified="2017-01-18" version="1">MGQETAPEIEGSAQGPTAGPPSGNTRRGVLVGAGLLGVVGVAAACGGEEETTEPGGGDGGGGGNAGGGGGGAGAVAQTSEIPVGGGKIFKDQNVVVTQPAQGEFKAFDIKCTHRGCPVDSVEGGTINCPCHASKFSIADGSVQSGPAGGPLKSKQVTVEGESIKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXH6</accession>
    <name>A0A1H6BXH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65388">
        <property type="protein sequence ID" value="SEG65388"/>
        <property type="gene ID" value="SAMN04489712_108101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="17240" checksum="D8FC90BE94A5BAF3" modified="2017-01-18" version="1">MADTGARIVDARTGRPRRSAVRWPGKRRIMEDVLMWFAAERRGGRRWIVPCLALAAGVAVAAVLAARDRTGAGLAVLAVLAAYAGHLAYRRDEPALPISAAFGSGHRARAHLRAAAITGDVLVAALVGAVVVQALRGGELLPYLWPAALAGVVYTLSAMVAGRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C268</accession>
    <name>A0A1H6C268_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteasome accessory factor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66787">
        <property type="protein sequence ID" value="SEG66787"/>
        <property type="gene ID" value="SAMN04489712_108224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="143"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="35000" checksum="20C06F470789481A" modified="2017-01-18" version="1">MSRRKTERLLNLVVCLLATRRYLTAEQIRRAVPGYPDSGDAFKRMFERDKEELRELGVPLEVGSEDGGEAGYRIPPQDYELPEIHLTPDETAVLGLAARVWQQASLAEAASGALLKLRAAGIDTSETDSLGIEPRVDTDEPAFPALWEAVKGAYPVAFDYQGIGRTAAARRHVEPWGVVSRRGRWYVVGFDTDRQGTRVFRLSRITGEVVPDGPAGSVTVPDGVDIRKIAFERSEAPAEPRTATVRLRAGAAQGLRRWAAEVHRTGGEWDEATLTFGEAERFAPHLARFGADVVVLDPPDLRDAVIQQLKSVLAGHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C6L8</accession>
    <name>A0A1H6C6L8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_1091</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68553">
        <property type="protein sequence ID" value="SEG68553"/>
        <property type="gene ID" value="SAMN04489712_1091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM2" evidence="10">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG68553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="537" mass="57447" checksum="2FAEB813713FF2C2" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAD8</accession>
    <name>A0A1H6CAD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_109122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69872">
        <property type="protein sequence ID" value="SEG69872"/>
        <property type="gene ID" value="SAMN04489712_109122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="4">
        <location>
            <begin position="38"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG69872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="160" mass="16643" checksum="2D2EC947501B3C33" modified="2017-01-18" version="1">MIGVRPAPSTPDGVRWPHVPPDDPSGHTVDGGMTAEALDVTLERRGPWTVLALAGALDFTTVGSLARRLDEVLAGAADRAPPPRLALRLADLAFCDSSGVNAIINVHKRLVAVGGRLVLVAPSRPVTRLLDITGLARCLTVTDTLPDGPPPGSRPEDEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CC21</accession>
    <name>A0A1H6CC21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70448">
        <property type="protein sequence ID" value="SEG70448"/>
        <property type="gene ID" value="SAMN04489712_109171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="29970" checksum="A50BCAB877A45229" modified="2017-01-18" version="1">MARKPRRSSDAVSPALRAFGNQVRHHRERLGLSQDRLGDRFPVSGSYIGLIETGKTRCTEDFAKKLDDHLTAYGALALLWEDLVQHAAYPTWFDWYLVERQAAMLQTFQLAVVYGLLQTPEYARVLLGDEAAVEARLARQAILTRSDPEPPMLVALLDESVLYRQIGDRKVMREQLEHLIAVSSRRISVQIVPMGVHDGLSGSFVLATMEDRSEVAYMDTALRGMTLGGKDGLKKISESLFDLRSKALSARDSQNLIQKTLEERWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEC9</accession>
    <name>A0A1H6CEC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein YndB, AHSA1/START domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71314">
        <property type="protein sequence ID" value="SEG71314"/>
        <property type="gene ID" value="SAMN04489712_109259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23576" checksum="02C66BB85D79F9A5" modified="2017-01-18" version="1">MIDATEQINAVRRQIGERVLEAGKARVSTIGQTYEAPIEDVWDACTNAERIPRWFLPVSGELKVGGRYQLEGNAGGTVERCDPPRSFAATWEFGGQVSWIEVRLTEEGDGRTRLELEHIAHVDDDLWAQYGPGAVGIGWDLSLLGLATHLSSGAALDPAEVAAWSASEDGRLFTALSSERWCEASIAAGTDKDAAQAAAERVFAFYTTPPEGAGEPAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIP8</accession>
    <name>A0A1H6CIP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72802">
        <property type="protein sequence ID" value="SEG72802"/>
        <property type="gene ID" value="SAMN04489712_11036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG72802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="27146" checksum="51A4C248C1290886" modified="2017-01-18" version="1">MVGHNGGMGTYLITGASGGIGAATAELLADRGHDLVLVGRSAERLAKVTTGLGSGAHARTQVLYRDAAGSPVPGASPAGRRGAVQSVVLDLAEPRRLEAALAVAGLPERLDGVVHSAGIVDLGPVAEQDADHWIDQLMVNLVAAAELTRLLLPALRAAEGHVVFVNSGSGLRARAGWSAYAASKHGLKALADSLREEEPRLRVTSVYPGRTATEMQRKVRAQEGGPYEPEKFMSAATVARVIVNALETPRDATVTDVSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIU6</accession>
    <name>A0A1H6CIU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72673">
        <property type="protein sequence ID" value="SEG72673"/>
        <property type="gene ID" value="SAMN04489712_11025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00880">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51708">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAD" evidence="1">
        <location>
            <begin position="231"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG72673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="532" mass="57916" checksum="A569621948C3F06F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJQ0</accession>
    <name>A0A1H6CJQ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73148">
        <property type="protein sequence ID" value="SEG73148"/>
        <property type="gene ID" value="SAMN04489712_11077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG73148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12365" checksum="9A823F1F5BE8FC51" modified="2017-01-18" version="1">MYTDTVAHPAIQVTSRRLAARTVVAIEGELDIASAAALREKLFAEFRRARAAVVLDLSGVSFCDAAGLSVLVAARRRARLLGLSLSLAAPRPSMSRLLQITGLQRSFDVCPTAGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKK3</accession>
    <name>A0A1H6CKK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate dehydrogenase E1 component beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73529">
        <property type="protein sequence ID" value="SEG73529"/>
        <property type="gene ID" value="SAMN04489712_110121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="7"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="330" mass="36006" checksum="D5602C988F530503" modified="2017-01-18" version="1">MTEPAVMTLAKALNEGLRRAMDDDPKVLVMGEDVGRLGGVFRVTDGLQKDFGEERVIDTPLAESGIVGTAIGLALRGYRPVVEIQFDGFVFPAADQIITQLAKMRLRSLGAVKLPVVIRIPCGGGIGAVEHHSESPEAYFTHTSGLRVVACSHPADAYTMIQQAVTCDDPVIFFEPKRRYWDKAPVDKSAAPGDWTPFDRAQVVNPGDDVTVLAYGPMVKTCLEAASAALEEDRSLEVIDLRSLNPLDIGTVVDSVRRTGRCVVVHEAPVFTGYGAELAARISEKCFYHLEAPVLRVGGFSTPYPPSRLEDHYLPDLDRVLDAVDRAMEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKS5</accession>
    <name>A0A1H6CKS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_110120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73522">
        <property type="protein sequence ID" value="SEG73522"/>
        <property type="gene ID" value="SAMN04489712_110120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="62"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG73522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="42494" checksum="21DCCE06FF7F43DC" modified="2017-01-18" version="1">MTIDSARGAPSPGASGPAGLDEAPPSPELIQLLTPEGIRVEHPDYPLELTPEEVRGLYRDLVMVRRIDLEAVALTRQGELGLWASLLGQEAAQVGSGRALAERDMVFPTYREHGVAWCRGLDPRRLLALFRGLSNCGWDPAEHNFHLYTIVIGSQTLHAAGYAMGIQRDGVLGTENAAAAIAYFGDGATSQGDVNESFVFASVFNAPIVFFCQNNQWAISEPLEKQSRIPLYKRAQGFGFPGLRVDGNDVFACLAVTRKALEAARSGQGPTLIEAYTYRMGAHTTTDDPTRYRLAAELESWKLKDPIERVKAYLVKNEMADAAFFGEVEAEAKRYATELRRDCLAMPDPKPLAMFDNVYAEPHSLITEEREQFAAYLDSFETEGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CL49</accession>
    <name>A0A1H6CL49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73690">
        <property type="protein sequence ID" value="SEG73690"/>
        <property type="gene ID" value="SAMN04489712_110142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021243">
        <property type="entry name" value="DUF2804"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35868">
        <property type="entry name" value="PTHR35868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10974">
        <property type="entry name" value="DUF2804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG73690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="38487" checksum="EBA5E2651FC02339" modified="2017-01-18" version="1">MATAEREITEPVPLCLPDGRLNPAATGWSRRPLHECDLRGWGRTKRWEYWCVTTPTHLVAVTVSDLDFLALNSVYFLEYGGREVERTALVPFGRGVRLPPVIAGTPGDLETDVVVGPERPTGGQVRVEIRAVAGGTRLRARCLTPDRQPLEVDLVVGLPDGHETLSVVVPWSDRRFQYTSKHTARPATGTVRIGTTVHEFGEDAWGVLDHGRGRWPRAITWNWGAASGRTGGRVVGLQLGGKWTDGTGATENALCVDGRLTKIGQELEWRYSASDFMAPWTIRTPDGDQVDLTFTPFHDRVTRTEAGLLANRTDQCFGHYSGRVRTDDGLDVAVDGLLGWAEEVHMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMJ3</accession>
    <name>A0A1H6CMJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_110206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74259">
        <property type="protein sequence ID" value="SEG74259"/>
        <property type="gene ID" value="SAMN04489712_110206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="13"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG74259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="515" mass="57067" checksum="47F9EFD4522F7EC1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT35</accession>
    <name>A0A1H6CT35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_111129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76152">
        <property type="protein sequence ID" value="SEG76152"/>
        <property type="gene ID" value="SAMN04489712_111129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG76152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="29345" checksum="7F7A98303821B522" modified="2017-01-18" version="1">MIGLRRRPRLPGPVERGEVALAARGVFVRRAGRDVLSDVGLQVRHGELLMLVGPNGAGKSTLLAALSGDLRPAAGEVVLQGRPLEAWTTRELAMRRAVLPQQHSLAFSFTVADVVRMGRSPWAGTPLEDEDDVVVLRAMRDAGIAEFADRAFTSLSGGEQARTALARVLAQHTETLLLDEPTSALDIGHQELVFSALCAEAERGRAIVAVVHDLDLAAAYADRVAMLSRGRLVACGPPPEVLTAPLLSEVYRHGIEVLPHPRTDRPIILPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV14</accession>
    <name>A0A1H6CV14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76870">
        <property type="protein sequence ID" value="SEG76870"/>
        <property type="gene ID" value="SAMN04489712_111218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="103" mass="11127" checksum="C0346AC4D0B8CAD9" modified="2017-01-18" version="1">MKPPESLTEVRARIDALDGELVRLLADRQRLVRAAATFKTDEQAVRAPDRVERVVAAVRERAAAAGLAPEVAESVWRAMIAAFIEYELAQHRSAADGTGTATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D158</accession>
    <name>A0A1H6D158_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Porphobilinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_112149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78980">
        <property type="protein sequence ID" value="SEG78980"/>
        <property type="gene ID" value="SAMN04489712_112149"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG78980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="301" mass="31237" checksum="A5B9165B25D17B57" modified="2017-01-18" version="1">MLGSAAWTLRPALLAMVILVRQDRSEGSLRAYTVQELPWVAQRVQAAGIEAVKLFAADQAGSSGIHGEDPGSVMARAIRIIKRTCPRLQVWTETCLCSHLPSGECHLSKDGRPDEAGTIAALSRQAVAQAAAGADVVGPAAMVPGSVEACRRALCAAGLGHVGVMPHLIMCSGLYSGYRATMGITPPAESRRFQLPVGGHTAAAVERGLLMLAEGANALLIEPALFSADILAGLRARTDAPLVAFSVSGECAALPPAILAEEYTMLLRAGASRVASHAALTVADTLSDRPSHRPTTGKPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3C7</accession>
    <name>A0A1H6D3C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MinD-like ATPase involved in chromosome partitioning or flagellar assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79488">
        <property type="protein sequence ID" value="SEG79488"/>
        <property type="gene ID" value="SAMN04489712_112223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="411"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG79488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="655" mass="67954" checksum="3DEE364274AAEB44" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D451</accession>
    <name>A0A1H6D451_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80139">
        <property type="protein sequence ID" value="SEG80139"/>
        <property type="gene ID" value="SAMN04489712_11323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="30"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="310" mass="33692" checksum="E16623D77BE72EB2" modified="2017-01-18" version="1">MRLGVLDVGSNTVHLLVVDAHRGARPLPAYSHKEEMRLAAHIEDGRLTEEGEARLLSFVREALRMAEDKGVEDLLAFATSAVREADNGEEVLARVNAATGADLQVLPGDEEARLTFLAVRRWYGWSSGRLLVVDIGGGSLEIASGIDEAPDVAISLPLGAGRLTRDRLGADPPSAEELRELRRYVRAEIARRVGEVARYGPPDHAVATSKTFRQLARIAGAAPSTEGPLVRRVLRHGDLVEWSEKLARMKARERAELPGVSEQRAPQLPAGAIVADAAMDLFGVEELEVCPWALREGVILRRLDTITGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4D0</accession>
    <name>A0A1H6D4D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol-1(Or 4)-monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80121">
        <property type="protein sequence ID" value="SEG80121"/>
        <property type="gene ID" value="SAMN04489712_11318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="29666" checksum="A0630BAA45701313" modified="2017-01-18" version="1">MNLTKEFRTTWTPQLAAAQEAARAAADAIRDQFGQRFISAYKGPYDVQLTADVIAQKVIVESLRESFPDYGIVAEEGDHDRWGAEEFLWAVDPLDGTNNFGYGIAHCAVSITLFHGESVVLAVIADPLTERLFHGVRGGRLSPLPSPPDGVPLHRATLSLVTGYAEEGRTWGYGFTGWMSTRCKRVVNMWAPAMDLALIAGGAIDAMVCRDAALLDVCGGMFLVEAAGGRLVDLAGEPLTVRRSMHRRPLSFIATRSPGLAADLAAEVRAYDGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7I0</accession>
    <name>A0A1H6D7I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81299">
        <property type="protein sequence ID" value="SEG81299"/>
        <property type="gene ID" value="SAMN04489712_11420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="113" mass="11895" checksum="0E9EAF1A7579CE4C" modified="2017-01-18" version="1">MALGPVKVATPAAALPYAIAALVLLPAVPYLLALIAGTQAALARALLQRGSGERLQAELVEVAHSRARLVDAFEAPSLVGPLPPGDRVCRWCPRWRWETAGRAKARSAARHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8X0</accession>
    <name>A0A1H6D8X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar or nucleoside kinase, ribokinase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_114114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81672">
        <property type="protein sequence ID" value="SEG81672"/>
        <property type="gene ID" value="SAMN04489712_114114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="9"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG81672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="30485" checksum="05600E5D8EA8C815" modified="2017-01-18" version="1">MNVPAPAGLLVVGDVVTDVLALHGQPPRPGTDTAADIVVAPGGSAANTAAWAAELGADVRLLARVGADTGGWHAARLRAAGVRPHLRTDPGRPGAVIIVLVDASGERTMLTSRGAGALLGPDDWDDALLEGVGWLHLSGYTLFTAPGRALARLALERAADRGVRVSVDPASTGFLAELGAERFLEAAGGAAVLFPNRDEAALLTGCQDAGTAAARLSGHFGLVVCKLGARGAVVAREGRLVARVPAVTARAVDSTGAGDAFAAGFLAAALAGRGAEAAAAAGCRAGALAVARVGGRPGPPGSPADPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAP6</accession>
    <name>A0A1H6DAP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81923">
        <property type="protein sequence ID" value="SEG81923"/>
        <property type="gene ID" value="SAMN04489712_114173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="477" mass="51987" checksum="01CDDC03111428ED" modified="2017-01-18" version="1">MFDVIVVGGGPTGLMLAGELRLHGVHVLVLEKDAEPTKIVRSLGLHVRSIEVMDQRGLLERFLAHGQKYVLGGYFAGINKPWPGRLDTAHSYILGIPQTVTDRLLAERAAEVGAEIRRGCELVGLSQDEDGVTAELADGTRLRARYLVGCDGGRSTVRKLLGVGFPGEPAENEWLLGEMEVAEDPATVAAVVAEVRKTHRGFGAGPIGDGVYRVVVPAAGVAEDRTVPPTLEEIKQRLRVFAGTDFGVHSPRWLSRFGDATRQAERYRVGRVLLAGDAVHIHPPMGGQGLNLGIQDAFNLGWKLAAEVGGWAPEGLLDSYHTERHPVAADVLNNTRAQSELMSLEPGPQAVRRLISELMDFEEVNRYLIEKITAIGVRYDFGEGHDLLGRRLRDVTLKQGRLYELMHGGRGLLLDQTGRLSVAGWADRVDHVVDASEELDVPAVLLRPDGHVVWVGEDQQDLLDRLPEWFGAAVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBA5</accession>
    <name>A0A1H6DBA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82558">
        <property type="protein sequence ID" value="SEG82558"/>
        <property type="gene ID" value="SAMN04489712_11543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="126"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="26358" checksum="BE9662AE25E46FE6" modified="2017-01-18" version="1">MGQGRAALRSIDLARAAGVSTQQIRNYEDAGVLPPVPRTSAGYRRFDTGHRRAVLTYRALARGYGWDTAQAIMRAVHAEDVPRALSLMDAGHAALHEQRLSLQATGEALEAVVEQDPGATAPPRPDMRIGEVAAHLGVRASALRVWEAAGLLTPEREPGTGYRRFGPADIRDAQMINLLRQGRHSLSQIGLVLDGLRRTGSSDALRAAIAQRRAELTQRARAMLEGSAHLHRYLTEERPDAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBG3</accession>
    <name>A0A1H6DBG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82618">
        <property type="protein sequence ID" value="SEG82618"/>
        <property type="gene ID" value="SAMN04489712_11551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="20754" checksum="29DBF305086F14AA" modified="2017-01-18" version="1">MARRQDPAGPRAAMIRSAIGLIRRRGVAAVSFADVLADSGAPRGSVYHHFPGGKSQLVEEATRSAAEQLSAAVARVLDASDTPGTLRTLADLWRRGLEAGDHAVGCPVVAAALGTERAARDVAGVAFGTWCDLISDKLVADGAERQRAQSVAVLVVGALEGALVLAQAQRTSAPLDAVVGELSALCRSVTERPDPAAANER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DD03</accession>
    <name>A0A1H6DD03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome segregation DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_115144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83094">
        <property type="protein sequence ID" value="SEG83094"/>
        <property type="gene ID" value="SAMN04489712_115144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="48"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG83094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="316" mass="34557" checksum="BE02484174EF3109" modified="2017-01-18" version="1">MTQQRRGLGRGLGALIPTGPPLGAPGGMAGGDGMATAQMEPVAGAHFAELPLDAITPNPRQPRSHFDEEALDELAESIRIVGLLQPVVVRRVTSERYELIMGERRWRASRRAGLEAIPAIVRETGDDDLLRDALMENLHRQQLNPLEEAAAYQQLLEDFGATHEQLATRIGRSRPHITNTLRLLNLPPAVQRRVAAGVLTAGHARALLSLDSPEAQDALAHRIVAEGLSVRAVEEIIAMRDIEDPPKVPRQGRKKPVAPALRALADRLSDRYETKVRVDLGRNKGKIVVEFASLEDLDRIIKAMAPDEPGVQDPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFK7</accession>
    <name>A0A1H6DFK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-(Hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83862">
        <property type="protein sequence ID" value="SEG83862"/>
        <property type="gene ID" value="SAMN04489712_11685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG83862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="358" mass="36802" checksum="2867CB8EA32B01B8" modified="2017-01-18" version="1">MRVAIAYEAGRPPVVEDLPVPDIGPRDVLVRIAASGICHTDLNVLEGRSALPLPIALGHEGCGTVEEVGPQVRRVRPGDRVLASVVPACGTCWQCVNGMSQQCELNPLVKAAVRFELADGRRAAAVCGCGTFAEAMVVHEASVVPVRTDLADEQLALLGCGVTTGLGAALNTAAVTPGSSVAVVGCGGVGQSVVQGARIAGAAMIIAVDPMPGRREAGRRAGATHTVDPAAGDPVVQVRELTGGRGADYAFEAVGRPELMVAAFDMARAHGTVTLVGMPPPGSALTLPAMQAVFSGKRLAGSVLGGAQILRDFPRFIRLAESGRLDLGSMVSRRIKLDEVAHGLDLVARAEGVRTVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DG33</accession>
    <name>A0A1H6DG33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_116138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84072">
        <property type="protein sequence ID" value="SEG84072"/>
        <property type="gene ID" value="SAMN04489712_116138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG84072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="97" mass="10767" checksum="B680544741328106" modified="2017-01-18" version="1">MAPTSSEEHADLAHLDDLSEELTGRGHLTMIVTDGTPRLNVLDRTDPDRYGTVICERGSEDDLWFWWSWADRIAPVTDLRRAAAVIDRTLSSADAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIA3</accession>
    <name>A0A1H6DIA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein, arsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84942">
        <property type="protein sequence ID" value="SEG84942"/>
        <property type="gene ID" value="SAMN04489712_11797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="247"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="323" mass="35118" checksum="B60B98EB1DD515BA" modified="2017-01-18" version="1">MGWWQVNADTLAESRFVISALAEAIASLKSLDRGTAAHPGEHVWLDAHLPAYRERLAGDPVTALLVRVGLGGRWNADFLTPTPAGEGEQSFEEELTRIRRTSAEAAQADLAVSVGGPLPAELRRPDLPERAAGVLEWVWRRAVLPEWPRRRRILEADVVARTGRLSSGGWAAAMGDMRPGMRWLGGGRLQINTYDYPPREIGEARLMFVPVTARRGWVSWDDGRRYAVVYPCSGTLAGPDGAVVPEALGRLLGPGRAGVLVLLDTPKSTTQLVALTGQGLGSVGRHLKVLLEAGLVRRRRAGRSVLYSRTRAGQVLVEAPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIN5</accession>
    <name>A0A1H6DIN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84476">
        <property type="protein sequence ID" value="SEG84476"/>
        <property type="gene ID" value="SAMN04489712_11710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG84476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="25220" checksum="BC59736648C8AE75" modified="2017-01-18" version="1">MAETDPLRAAMIEAAERQLASSSDHEIATRAVCEAVGVSQPVLYRLFGDKRGLLDAVADHGYERYTALKAAQEQTGDPVADLHAGWDGHMAFAQANPALYQLMFTPRPWSHSTARERVMDLLVATLTRCAAAGALKLEPQTAAQLILSANVGTALDHIARPALFEDPALSHRMRDAVFSHVLTTTPTQHNTDPLRTAALRLHAQLQLGGTEALEPVEIALLQRWLERITHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIP7</accession>
    <name>A0A1H6DIP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_117126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85059">
        <property type="protein sequence ID" value="SEG85059"/>
        <property type="gene ID" value="SAMN04489712_117126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="2">
        <location>
            <begin position="168"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="299" mass="31762" checksum="C1AE418741666868" modified="2017-01-18" version="1">MDARLTTEQRELRAAAARLADELGPGSVLDLDDADRVARLEKAVAATGWRTLRSDGASGVEVALVAEEFARGLVDVPFAGPVLADDLRRDDTAEPWTVAVDGEAADARDARRVLVLQGRRILAGRAGHAVAGVDLTRRNAEVSGPFEPVGEVSAEHAERWRALALVVTCADLLGAARGAHTLACEYAKVREQYGNPIGSYQAVAHLLAEGLALIEGSISVLRHAAWAVDELTPAEAVHAARVAKLYCARAARTVCETSVQVHGGIGNTWECLAHVYLRRVLASTDLFPAGLEEIDLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL19</accession>
    <name>A0A1H6DL19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR03084 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85831">
        <property type="protein sequence ID" value="SEG85831"/>
        <property type="gene ID" value="SAMN04489712_11888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017518">
        <property type="entry name" value="CHP03084"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03084">
        <property type="entry name" value="TIGR03084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Wyosine_form" evidence="1">
        <location>
            <begin position="180"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="27476" checksum="141B25E4AA95051C" modified="2017-01-18" version="1">MPDPQILIADLDAEGDALEALVAPLDAAGWATSTPAEGWTVAHQISHLAWTDRQALLAATDPAAFADAVAGLRADSVDEGAAEGAGEDPARLLERWRAGRRDLSKALLAVPAGTRIPWFGPPMSAASMATARLMETWAHGLDVADALGVTPEPTGRLRHVAHLGVRTRDYAFGVRGLTPPAEEFRVELTGPGGLEWTWGPTGARQSVSGPALDFCLLVTRRRHRADLALAAEGADADRWLDIAQAFAGPPGPDRPPSAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DM39</accession>
    <name>A0A1H6DM39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86380">
        <property type="protein sequence ID" value="SEG86380"/>
        <property type="gene ID" value="SAMN04489712_11966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="13"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="316" mass="33017" checksum="9206E5183C2680AD" modified="2017-01-18" version="1">MRAAYFTTPLAEDPVNAIEVGDLDLPEVPDGWSRVDIYAGALNMHDLWMLQGVATVPGGAAHVIGSDGAGICEGQEVLVYPVLPTQGRSLAHSVLLSDRGYGLLAEQAVVPAGGVVPKPAHLTWEEAAAIPTAWLTAYRMLFTKARIRAGQTVLVQGAGGGVSTAVIALAKAAGASVIVTSRSAAKRERALEVGADVALPTGERVPELADIVIESVGPATFDHSVMSTRAGGTIVVCGASTGFTTPLNLARLFAREITVQGSTMGTREEFAALVDFIERHRIRPTIDSTVGLDDIRVLAKRMLGGDAFGKLCAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQL7</accession>
    <name>A0A1H6DQL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske-type oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_120152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87541">
        <property type="protein sequence ID" value="SEG87541"/>
        <property type="gene ID" value="SAMN04489712_120152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG87541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="381" mass="43302" checksum="4FC3AC8C88436735" modified="2017-01-18" version="1">MTAAESDAIRVIEAEAIPARFARGWHCLGPAEKFSDGRPHTVNAFGQKLVVFRGANGNLNVLDAYCRHMGGDLSQGTVKGDEIACPFHDWRWGGDGRCKKIPYSRRVPLRARTAAWPTLLQDELLFVWNDPEGNPPPADVTIPRIEGVTSDEWTDWLWTETVVHTNCREVIDNVVDMAHFFYIHHSFPTYFKNIFEGHTATQIMKGKTRPDIARPDAEGNTMLGNTSVATYHGPAFMVDELTYHYQGFDLESVLINSHYPIDEHSFSLHSGIIVRRSEQLKGPAAEVTARKLSGFIQRGFEQDIAVWRTKTRIDNPLLCEEDGPVYQLRRWYEQFYTDAAEVTPEMTGRFEYEIDTTRPVEAWTRETEENLARRAAEGQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVI1</accession>
    <name>A0A1H6DVI1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="9" type="ORF">SAMN04489712_12375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89357">
        <property type="protein sequence ID" value="SEG89357"/>
        <property type="gene ID" value="SAMN04489712_12375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG89357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="523" mass="57853" checksum="65C32D2536FEC84A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY07</accession>
    <name>A0A1H6DY07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RfaE bifunctional protein, domain II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89636">
        <property type="protein sequence ID" value="SEG89636"/>
        <property type="gene ID" value="SAMN04489712_12413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="50"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="21810" checksum="FAFCB9D637C404FB" modified="2017-01-18" version="1">MVAGNAENRPLVSRGFFADASNFELRYVQDYERIKEIVSALRAVDYRIVLTNGSFDILHEGHSMYLEACRGFGDFLIVGIDSDEKIRARKGPHRPAVPEIERLRMVTHQRGVGLVTLKHLNRPKWELIKAVRPDVLVATAETYTPAEIEELESHYCGEVRVLERMATISTSARLRRIQLGLAEPEPRVTADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYE5</accession>
    <name>A0A1H6DYE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">SAMN04489712_12461</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89776">
        <property type="protein sequence ID" value="SEG89776"/>
        <property type="gene ID" value="SAMN04489712_12461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="4"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG89776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="31581" checksum="56795D4B6548ED78" modified="2017-01-18" version="1">MKHLHSGKVRDLYELPGGELLMVARDTISAYDFVLDSPIPDKGRILTQLSLWWFERLADVLPNHVISTELPDGAPAEWAGRSVVVRRLDMVPVECVARGYLTGSGLKEYGRSGSVCGVPLPEGLMDGSRLPEPIFTPTTKAAVGDHDEPMTFAEVEAAVGAEVAGRLREITVEVYRRGAELAAERGIIVADTKIELGWSPEGELVLADEVLTPDSSRFWPADRWRPGRPQPSFDKQFVRDWLVSPEAGWDRAAGDPPPPLPPEIVERTRAKYVEAYERLTGRTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ08</accession>
    <name>A0A1H6DZ08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vanillate O-demethylase ferredoxin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90401">
        <property type="protein sequence ID" value="SEG90401"/>
        <property type="gene ID" value="SAMN04489712_12626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="228"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG90401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="319" mass="34544" checksum="7C038D30B38280D3" modified="2017-01-18" version="1">MTWTEAVVVSHSPATPDIAVIDLAPATGDEFPAYTAGAHIDVLITPNLVRQYSLCGPPEQGRYRLAVLNEPASRGGSRAMHALKVGDHLRISAPRNHFPLVTARRHLLFAGGIGITPLLAMARQLEREGGDYALHYCARSRARAAFVKELAGNPRVALHFDDGDPRQQLDLARDLGDPQPDTAVYVCGPDGFMDHVLGKAEALGWPPQSLHKERFGTAPEPTASGDSFTVRLASTGAEYLVPDDRSVLDVLLENGVDAPYSCRQGICGTCVVRVLAGHPDHRDEVLTNEEHAEGLFTTCSSRSLSPTLKLDVIPRRDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZK0</accession>
    <name>A0A1H6DZK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90176">
        <property type="protein sequence ID" value="SEG90176"/>
        <property type="gene ID" value="SAMN04489712_12560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="109" mass="12055" checksum="B4CFD0D167D1AE22" modified="2017-01-18" version="1">MSTGRRWQDIKAEAHRRHPELADPERRERARAELDAYVAGHHLKELRKAIGKTQAEVAQILGVSQSRISQIENGDIKAMELETLRAYAAALGGHLDITISVGPHSVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2N5</accession>
    <name>A0A1H6E2N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91882">
        <property type="protein sequence ID" value="SEG91882"/>
        <property type="gene ID" value="SAMN04489712_13113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="252"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="480" mass="50219" checksum="6C11A7A647DC3800" modified="2017-01-18" version="1">MVIATLAPDAPGDLMIDIVDVRKRFGATQALRGVTCSFSRGEFVALLGSNGAGKSTLVKILDGVYPADAGTIAVRGGRAGLGVVHQDLGLVDGMTVAENLCLGAPRRLVNPRAEARLTTEALRAVGLTSIDPYALVSTLSLGQRAMVAVAKTLHRGADTVVIDEVTAGLHPHEARWVVERLRVAAEFGATVLMVTHKLDEVVGAATRYVVLSDGEVALDEDAGGIARADLVAMMSRGRSVSAPAPGAGRVDASGGGIVCELKGVHAGGAGPIDLTVTEGRITAITGPLGSGLHEVAYAAAGLLTPDAGTVRVASDVRRACVPAHRESEGVFAEHTVQFNVAVGGWSRWRGRTGLLRVRQMRRDCDDAVAALAVVPHRLDATVSDLSGGNQQKTLFARALMRRPRLLVLCEPTRGVDVATRREIYAQVRRMADSGTGVLMASTDYEDIAALADTTGVLTADGTVSEWLTPDRLPELTTELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2W4</accession>
    <name>A0A1H6E2W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92058">
        <property type="protein sequence ID" value="SEG92058"/>
        <property type="gene ID" value="SAMN04489712_1327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="451" mass="48953" checksum="65A03372898211E9" modified="2017-01-18" version="1">MTAESTEPAPPPGCPAHGLVKMYGHEFAADPHGTYARLREHGQFAPVEIAPGVPATLAIGYDAVLEMLRDDRTFLNNPSEWQKTVPPDCPVLPMMGYRPNALFADGTVHARLRGAILDSFARLDTATLRRYVERSADTLLQWIGPHGQADIQGEYAMALPVLVFMELFGCPSDISEKIVSGMSGIFEAIDAEKANAELAEGIMELVAHKRARPGEDITSWLMAHPARLTDEEMAHQLTVLLGGGIEPAGNLISGALRLLLSDDRFAGDLSGGSVPIEDALDEVLWTDPPIANYAARYPVRDVELAGHLLPADRPVVISFAAANTDPSKAGEQRVGNRAHLAWGAGPHLCPVREEGRLIASIALEKLLDGLPDMELAVPVEELEWRPGMFHRAPVSMPVRFPPVHTPEAPKQEHNARPVTPMPDSRAAHAPVAQPSGLRRLVASVTRWWRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E449</accession>
    <name>A0A1H6E449_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92357">
        <property type="protein sequence ID" value="SEG92357"/>
        <property type="gene ID" value="SAMN04489712_13326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296519" evidence="1">
        <location>
            <begin position="32"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="2">
        <location>
            <begin position="58"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="44017" checksum="9F3295E5F432A9D1" modified="2017-01-18" version="1">MTSTWRKAVAGALVAAGVPCVIAAPPASASALDRFERFRITRFLGEQRLPHRMSFEGTTVGGLSGIDYDPTTRNWYFISDDRGRHNAPRFYRGRLDIHPETGAFAGVRMTEVTTLQRPDGHRYAPHGRPRSADPETIRFDPWSRRVVWGSEGDRPDAANPHIPLTQPFVRWNGKDGRHLRELQLPSNLLLSTAGHGPRRNYSIEGLALAPRFIAVMQEGPGYEDGPVPTVEHGATTRVTLWDRWPRRRLYAQYAYRLDRLPAAPRPAGGSHDSGVSEILAIDNHRYLALERSWIQGVGYRAKLYEFDTRDATNVLAKDSLAKGRGYRPVTKRLVRDLGSFRRPVQNLESLSWGPRLRSGECTLLIGSDDNFDRQEVTQFLLFAVRGLRGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4D3</accession>
    <name>A0A1H6E4D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91745">
        <property type="protein sequence ID" value="SEG91745"/>
        <property type="gene ID" value="SAMN04489712_13038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="236" mass="27184" checksum="3024D8C9E172AB49" modified="2017-01-18" version="1">MPPARLKVPWEQVEEYRAREARWERVNASGLSLDDPRESVAEGVIEELFDEEKVWLDHRSSGVVCITDPARLALELGLDEQQLTGHPDAFVEDGVLVAPWEVTELIATTAVRRNPEPFLLQVRNEERKARYEAIHGRWSRGGRRSNDHYFEPEFCAKFDNDYYRPRREILLSWCGVDAVERFDELVELRKEVRRVGELAQSAIDALKAAGHASEASRLQRELGTPVETLRFEETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4K5</accession>
    <name>A0A1H6E4K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_13442</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92590">
        <property type="protein sequence ID" value="SEG92590"/>
        <property type="gene ID" value="SAMN04489712_13442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
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        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
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        <property type="entry name" value="Chitinase_insertion_sf"/>
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        <property type="entry name" value="FN3_dom"/>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro18_cat"/>
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        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
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        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="fn3"/>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_18"/>
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    </dbReference>
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        <property type="entry name" value="CBD_II"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296554" evidence="8">
        <location>
            <begin position="37"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="10">
        <location>
            <begin position="32"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="152"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="244"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="613" mass="62938" checksum="C73669BABF672715" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4L6</accession>
    <name>A0A1H6E4L6_9ACTN</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">SAMN04489712_13448</name>
    </gene>
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        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="20617" checksum="6C6D2029D6132938" modified="2017-01-18" version="1">MELRPLMAQAAEAAVAVVEGIDETRLGDPTPCPDFDVRALVNHLIKWTSGPGEAAARKTPPPDSADGDTDLTAEPGWASRYAERARRTGAAWSEPAAWEGVTALTPAGQMPASFVGGMMFAEFLLHGWDLAAATGQKPGFGDELEQALWRQVREMADTARKYGAFGPQVEVPESAPPLDRALGLAGRDPHWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5Q5</accession>
    <name>A0A1H6E5Q5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92529">
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        <property type="gene ID" value="SAMN04489712_13425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
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        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="131" mass="14877" checksum="D98FEAA932701793" modified="2017-01-18" version="1">MDVLSSRTLLRPADPARSHRFYREVLGLAVHREFGPPDEPGVVYFLGQGLLEVSGRSDDGPGGAMMLWLQVRDVEAEHRRLREAGVSVLREPRQEPWGLIEMWIEDPDGVRIVLVEVPADHPLRRDLRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E732</accession>
    <name>A0A1H6E732_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93550">
        <property type="protein sequence ID" value="SEG93550"/>
        <property type="gene ID" value="SAMN04489712_13928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="97" mass="10140" checksum="D1F64F28AC6DFED3" modified="2017-01-18" version="1">MQLGKLSLINLLMEEGEEDSAVLLAGSDLPDTLDTDRDLPALRALGIDEDDLRTLLPAVTGGPDRGPGLSADAAAALDRTISERWAALVAGWTGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8F3</accession>
    <name>A0A1H6E8F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG94002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94002">
        <property type="protein sequence ID" value="SEG94002"/>
        <property type="gene ID" value="SAMN04489712_14223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="22150" checksum="170DC26185A11D6C" modified="2017-01-18" version="1">MSDETSSTRDRLLAAAERLLLSKDPDQVSVRAVNAEAGLNSGAVHYHFGSREGLIAALLERELVPVWADRLAPIIRRSEQPDEGEPFSVADLVAAIVQPFEELVRTEKGRMLCRLLARTTLPRWRIPASSPWFSSAPFEVMLGRAMPELSVREISERWRLAFTLLLEIYGQASDPSSARPQIQSETLIAFLSAGLTAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E928</accession>
    <name>A0A1H6E928_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93355">
        <property type="protein sequence ID" value="SEG93355"/>
        <property type="gene ID" value="SAMN04489712_13829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="70" mass="7550" checksum="C5E1F52EA511170B" modified="2017-01-18" version="1">MYSVEDASAMAVLRIRYPQALIIPMSCGMWVGHTCVGLTRAESPGQLDERLAEIYAEPCPVIPLRGSNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E983</accession>
    <name>A0A1H6E983_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system, OmpR family, KDP operon response regulator KdpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93496">
        <property type="protein sequence ID" value="SEG93496"/>
        <property type="gene ID" value="SAMN04489712_13915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG93496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="25259" checksum="0FC0746B714DFF26" modified="2017-01-18" version="1">MTRVLLVEDEPQLVRALRINLRTRGYEVEAAPDGRTALDLAARRHPDVVVLDLGLPDMDGVEVIEGLRGWLSVPIIVLSARHASEEKVRALDIGADDYVTKPFGMDELLARLRAAVRRAAPAEQAAVVETATFTVDLAAKKVLRDGREVRLTPTEWNILEVLVRNAGRLVGQRSLLREVWGPAYEKETNYLRVYLAQLRRKLEPDPARPRHLITEPGMGYRFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9D6</accession>
    <name>A0A1H6E9D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted metal-dependent hydrolase, TIM-barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93546">
        <property type="protein sequence ID" value="SEG93546"/>
        <property type="gene ID" value="SAMN04489712_13927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="97"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="45549" checksum="9EB1A148CC81A253" modified="2017-01-18" version="1">MAHELPFRFFDCDNHYYEALDAFTRYIEPEFRKRTMQWVQIDGKTRLLVAEKVNKFIPKPTFDPVAAPGVMDEYFRGRNPKSADPSKLMGELEPIRPEYRDRDARLAVMDEQGMEACIMLPTLGVGMEVALCHDIPALAAAFRAFNRWVEEDWGFAYLNRIFAAPYITLADPDNAVRELEWALERDARFLVMIPGPVLTEVGPKAPADPMFDAFWQLVNDSGITVLYHGGETHYTKFLAEWGERNFTEAFRANAFRGLVSADPMQDTIASHLALGLFKRFPNLRMASIEIGSAWVFHLFEKLSKSYGQVPHLFPEDPRETFKRHVWVSPFYEDELRSLLELLGAERILMGSDYPHVEGLADPASYIKDLENFDYTPEQCETVMRTNGWELSTRRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9W9</accession>
    <name>A0A1H6E9W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR system Cascade subunit CasB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93899">
        <property type="protein sequence ID" value="SEG93899"/>
        <property type="gene ID" value="SAMN04489712_14126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013382">
        <property type="entry name" value="CRISPR-assoc_prot_Cse2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038287">
        <property type="entry name" value="Cse2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09485">
        <property type="entry name" value="CRISPR_Cse2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02548">
        <property type="entry name" value="casB_cse2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="215" mass="23823" checksum="3F10AC45EA8CA201" modified="2017-01-18" version="1">MTMASPARPRSVMELVGDVVEKRVAELQRGYLDDQSAAVAALAQLRRGAGKLPQDMPELWGVTGVELLFQDQALPDREASRAEAALFLAVTLYALHQQSRSDQRMHKAGIELGEAVRRLMSGGDIDEPIRRRFVRVGAATTPEVLAYRLREIVSLLRREAIPLDYARLARRLYQAQVPGGMQQVRQIWGRSFHAYRPQTSTTGTAGNGATNDKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECU2</accession>
    <name>A0A1H6ECU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000049">
        <property type="protein sequence ID" value="SEG94625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94625">
        <property type="protein sequence ID" value="SEG94625"/>
        <property type="gene ID" value="SAMN04489712_1499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="28792" checksum="DEF390CF4FF44309" modified="2017-01-18" version="1">MNIAIVTGGASGIGRAIATALVARGDTVIVTDINAPGAESVAERLNTLGRGRALAEGLDVTDAEAVATLYKKVHAEHGRLDLVFNNAGIAIGGLAEELTLDHWNRAIDINLKGVVHGVQAAYPLMLEQRSGHIVNTASLAGLVPMPMGIPYTATKHAVVGLSLGLRAEAASAGVKVSVVCPGFVDTPLLANINPGLPETPMSGDGRAQIKKQAGGFYTVERLARDVLRGVARNEALIVAPATGRTAWRGMRLSPKLAVRAAQFAATRYRREHHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5RZ48</accession>
    <name>A0A1H5RZ48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, MSMEG_2516 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43384">
        <property type="protein sequence ID" value="SEF43384"/>
        <property type="gene ID" value="SAMN04489712_1016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019923">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03621">
        <property type="entry name" value="F420_MSMEG_2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF43384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="312" mass="34483" checksum="876EFD68984ED512" modified="2017-01-18" version="1">MRDFRFGFNFFDVPPREDFVARCRTAERLGYDVALVPDHLGGPAPFPTMVAAAEATERLRVGTLVLNVPFWNPHLLAREVATADRLTGGRVELGLGAGHMKWEFEAAGLPWEPFGARTDRLAETIEELGRLFGGPGYEQHAARDAEYGLAELRPVQRRGFDGSGPPLLIGGTGDRVLRLAARHADIIAYAGVYQLKGEPPGTFRIGTAAEAGERVEFVRGLMGERADEAEASILIQAVVVTDDRRAAAERLSAERLPFLTPEEILETPFLLIGTYEQMAGQLVERRERFGFSYITVHGPYMETFGSVIERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S592</accession>
    <name>A0A1H5S592_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase-3 subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45789">
        <property type="protein sequence ID" value="SEF45789"/>
        <property type="gene ID" value="SAMN04489712_10186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="233"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF45789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="595" mass="64273" checksum="C9A92A7E835E177C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SLG6</accession>
    <name>A0A1H5SLG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50691">
        <property type="protein sequence ID" value="SEF50691"/>
        <property type="gene ID" value="SAMN04489712_101236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF50691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="39822" checksum="98C8517C3FA67247" modified="2017-01-18" version="1">MLPWSADLSGRLDRHVFTSELLRGNPLGDPHERPLWVYVPPGYEDEPDRRYPSIYVIQGYTGHIEMWSNRTAFRRPFPETADAVFAEGQAPPAIVVYVDAWTAYGGSQFVDSPGTGRYHSYLCEELVPWVDAHYRTLADRDHRAISGKSSGGFGAMITPMLRPDLFGALATHAGDALYEYGYIPEFPKAVRHLRGYDGDIFRWWDDFRGRTAFTRQEDQDLLMLLGVSACFSARDDGTPELPFDPRTGVLRQEVWQRWLDLDPVRMVPRHAEAVRSLRAVWIDGGTRDEWYLDVGAQAFRQALADAGVPDEVIHFELFDAGHGMIDYRYPQALAWLCHRIAPPEEGARPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SPM1</accession>
    <name>A0A1H5SPM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid transport protein (AzlD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51791">
        <property type="protein sequence ID" value="SEF51791"/>
        <property type="gene ID" value="SAMN04489712_101279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF51791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="103" mass="10643" checksum="855CCE3910193B1A" modified="2017-01-18" version="1">MNTWIAVLATAAGCYALKLGGLVTPQRILEDPRVRRFTELVPVALLTALVAVQTFAAGRALELDAPRLAGLGAAVAALLLRAPFLVVLVIAAGTAALLRLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SRU2</accession>
    <name>A0A1H5SRU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpA</name>
        <name evidence="9" type="ORF">SAMN04489712_101333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53150">
        <property type="protein sequence ID" value="SEF53150"/>
        <property type="gene ID" value="SAMN04489712_101333"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF53150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="28090" checksum="B2BAD7CC85FE3FD7" modified="2017-01-18" version="1">MTTAIAFEKAKADGRSALVGYLPAGFPSLQGAVKAATAMVEAGCDVIEIGLPYSDPMMDGPTIQDAVHRALTGGVRVADVFRTVEAVAATGVPTLVMTYWNPVDHYGVDAFARDLKSAGGAGLITPDLTPEEAGPWLAASDAHDLDRVFLVALSSTTERIAKIVDVCRGFVYAASLMGVTGARRAVDTGAPALVERTREVISRRLEGAAPLPVGLGLGVGSGAQAAEVAGFADGVIVGSAFVRRLLDAPDEAAGIRAIREFTAELAEGVRQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SY52</accession>
    <name>A0A1H5SY52_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chorismate mutase</fullName>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54781">
        <property type="protein sequence ID" value="SEF54781"/>
        <property type="gene ID" value="SAMN04489712_101388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02185">
        <property type="entry name" value="AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008243">
        <property type="entry name" value="Chorismate_mutase_AroH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21164">
        <property type="entry name" value="PTHR21164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07736">
        <property type="entry name" value="CM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005965">
        <property type="entry name" value="Chor_mut_AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01796">
        <property type="entry name" value="CM_mono_aroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51167">
        <property type="entry name" value="CHORISMATE_MUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR005965-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF54781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="13344" checksum="D74627EF5925732E" modified="2017-01-18" version="1">MAVRALRGATQVDADERDQILEATTELVTEVMRRNGLSTDDVISVIFTTTPDLNAEFPALAARKLGFHEVPLLCASELDVPHALPRVIRLMAHIETDRPRSEMQHVYLRGATALRLDIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SYW1</accession>
    <name>A0A1H5SYW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55802">
        <property type="protein sequence ID" value="SEF55802"/>
        <property type="gene ID" value="SAMN04489712_101419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF55802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="422" mass="42337" checksum="71D810A974F882C3" modified="2017-01-18" version="1">MGIVGAVPIDERAGRPADPVADWACSGVVALTGRADGPPLVPPGRAATVADGLAARFAAITGVRVDGARLLSERAAFTGHGRRGPVSAGGACRLLPTADGWAAVSCARPDDPALLGALVCAQVDEDPWPAVNAWLRGHTGAELAERAALLGVAAGPVRPRDVPPALPEPPATRSPDGLLVVDFSALWAGPLCAHLLGLAGARVVKVETPWRPDGARRGNAGFYRLLHAGHRSVALDPHTAGGRRAMAALVAAADVVIEASRPRALAGFGLDAEAAAAAGTVWVSITAHGRGDDRVGFGDDVAAASGLVARDAGGVPLFCGDAIADPLTGLAAAVLATSAPTGGTGTLWDVSMSDVVAATLDPDGGAPPASPAARPDGDGWVVDTSSGPVPVALPERRHVPGRVPDLGEHTTEVLDELGIPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SZ20</accession>
    <name>A0A1H5SZ20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Molybdate transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_101400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55178">
        <property type="protein sequence ID" value="SEF55178"/>
        <property type="gene ID" value="SAMN04489712_101400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="10">
        <location>
            <begin position="283"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF55178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="37316" checksum="B9D82D76192AE606" modified="2017-01-18" version="1">MTVLDAHLTVRRRDFRLDLPLTAAAGEVVALLGPNGAGKTTALRALAGLLPLDGGHIRLDGEPIGALPAERRPVGVVFQDYLLFPHLSALENVAFGPRCQGVPRRAARERAAGWLERVGLGEHLAKKPRALSGGQAQRVALARALVTEPRLLLLDEPLAALDAHTRLEIRSALRRHLAGFAGATILVTHDPLDAMVLADRLVVVEQGRMVQEGPPAEVARHPRTDYVARLVGLNLYRGRAHGHTVTLEGDKGPVRFDATEALEGEVFVAFAPSAVALYRTRPDGSPRNRWRARVETIERHGDRIRVGLSGPLPAAADVTPGAVAELGLAEGSEVWAVLKAAETHAYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TBH6</accession>
    <name>A0A1H5TBH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60139">
        <property type="protein sequence ID" value="SEF60139"/>
        <property type="gene ID" value="SAMN04489712_101555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF60139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="32732" checksum="CE8E06C37295DC81" modified="2017-01-18" version="1">MIGYIVRRLLLVALVACGVTTLLFVLARLSGDPAELLSPPEAPPEVVEATRIRLGLDAPLAVQYAKALASSFTLDFGQSFAFHQPAAQMVFQRLAPSLWIVVPSIVLSVLLSFAIGVAAALRPSRLSGRLLMAGTFLTGSVPYFWLALLLVLLFAVNLGWLPATGGEGFTSLVIPVTALTVAAVSTSARLARGQLLDSFGEGYVLTARSKGVAPWRVLLGHALPGALPPMLAWLGIEFSFLFSALLVLEPLLGYNGLGALLIRSVANQDFPLVQASVFCMAMLITLVNIGMDVIVRLVDPRLRTKAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TC02</accession>
    <name>A0A1H5TC02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-methylcytosine-specific restriction endonuclease McrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59547">
        <property type="protein sequence ID" value="SEF59547"/>
        <property type="gene ID" value="SAMN04489712_101538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF59547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="146" mass="16690" checksum="13C247EC565D06FB" modified="2017-01-18" version="1">MNVLVLNASYEPLQQVDLRHAIRMLVRGVAVVEEAEEGRTIGSFPVPRVLRLVRYVAMRWRYGRRPPWSKRGVHLRDRGLCGYCGRRGHTIDHVVPQSRGGADTWENTVLACGRCNNRKGSRTPAEAGLRLRVEPRVPRWDELIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TEQ3</accession>
    <name>A0A1H5TEQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6285 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61322">
        <property type="protein sequence ID" value="SEF61322"/>
        <property type="gene ID" value="SAMN04489712_101591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046252">
        <property type="entry name" value="DUF6285"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19802">
        <property type="entry name" value="DUF6285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6285" evidence="1">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF61322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="12291" checksum="0E949C1D5C3EE2F7" modified="2017-01-18" version="1">MAPPHDAPSAGELVAAVREFLEREVLAGLEGRARFHGLVAVNVLGMVERELEHGPAQRAAHRERLAALGFDDDAALAAAIRSGALDDRYAELKAALRDTVRDKLAVANPGYAEPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TGZ8</accession>
    <name>A0A1H5TGZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic selenocysteine-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61478">
        <property type="protein sequence ID" value="SEF61478"/>
        <property type="gene ID" value="SAMN04489712_101596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02786">
        <property type="entry name" value="MopB_CT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037920">
        <property type="entry name" value="YoaE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF61478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="684" mass="73848" checksum="2FF12CF96264DCE0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TJF2</accession>
    <name>A0A1H5TJF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62298">
        <property type="protein sequence ID" value="SEF62298"/>
        <property type="gene ID" value="SAMN04489712_101623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF62298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="21744" checksum="B0817A9C640A4BA3" modified="2017-01-18" version="1">MSVERLVTSGQFTLDGGTWDVDNNVWLVGDDREVIVIDAAHDADAILSAVGDRELKAVVCTHAHNDHINAAAAVADRTGAPILLHPADAVLWDMVYPDRGPDRALADGQEISVAGTTLKVLHTPGHAPGAVCLYAPELDAVFTGDTLFAGGPGATGRSFSDFGTIIDSIRDRLLTLPGDTVVRTGHGDATSIGAESPHLEEWIARGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TJN0</accession>
    <name>A0A1H5TJN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-containing redox enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62378">
        <property type="protein sequence ID" value="SEF62378"/>
        <property type="gene ID" value="SAMN04489712_101626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF62378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="37323" checksum="77EA893F761035DD" modified="2017-01-18" version="1">MTSTADFPVETGPVVPPAPRGPLSEAVVSALRSSVPGTARFPVAEVRSADPLGEDLQLALYTCYELHYQGFQDVDPGWEWEPELLRFRGAVEGVFLAELRAGVPGGDDVGACLEELLVEPVDARGVSHFLKDEGEWWQLREYLVHRSIYHHKEADPHALLIPRLRGQAKASLVAVEFDEYGGGRWERMHSRLYADLMDEVGLDDGYLRYLDAVPAVMLATVNMMSLFGLHRALRGAMVGHFAAAEITTAPSARRMAEALERLGVGPRGTLFFTEHIEADAVHEQVLRHDVLGDLLRREPGLAADVVLGVQATSLLEERLGDHLLGCWGAGRTSLLRPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TLZ7</accession>
    <name>A0A1H5TLZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine phosphatase RsbU, regulator of sigma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63794">
        <property type="protein sequence ID" value="SEF63794"/>
        <property type="gene ID" value="SAMN04489712_101673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="33"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="206"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF63794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="443" mass="47205" checksum="D8C8DF60BBE039C5" modified="2017-01-18" version="1">MGSARMIASTAVSPDAERRRLAAVRRYAVLDTLPDGTFDRVTSLASRIFDTPIATVSIVDERRVWFKAARGLPQGLRQTTREPGLCATAILHEGAYVVNDTLADPHAAVHPLVTGEPEARFYAAASITTSDGQCLGTVNVLDVRPRQVTDEQLAALEDLAALVMDELEQRLAAVRTLTTERRLRTDAERLARTLQRTLLPPALPKVPGLQAAAAYHTASVYEVGGDFYDLFPLNDGRWGFFLGDVCGKGADAAAVTSLVRYTLRAAAVYDPDPLAVLVNLDTVMQQETQDHNARYCTAVFGLLQPDGDDFVLTLADGGHPPPLAVRRDGAIEPIHAPGGQLIGILPKPNFVQSTARLHPGDTLLLYTDGLTEARTSTGSMLGEEGLTAHLAAHLPAARPGAHGILAAVHELIDGLGGGVSDDTALLALSVADRPIHPSAEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TXY5</accession>
    <name>A0A1H5TXY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66877">
        <property type="protein sequence ID" value="SEF66877"/>
        <property type="gene ID" value="SAMN04489712_101764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF66877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="30851" checksum="10EBAD78C6295EA0" modified="2017-01-18" version="1">MLIDSDAYLRDTPASGRTVRVEEPAPGVRLLTLDREHRLNAMSGELIKDLHTALDGIAVDEDCRVVVVTGAGRAFCAGLDLHEPPAREAAPAATEEAAARRRSPQAGMHVQQAIASLVPKLRNLRQPVIAAVNGPASGGGFALALASDVRIAAASARFNAAFVKIGLSGCDIGVSWLLPRLIGAGLSHELLLTGRFVDATEALRIGLVSRVVEDGSVVQAALETAALICANSPMGVWMTKEVAWSQLEVGSLQAGIDLENRTQILTSYTRDQTEQITSFLQRRPPEYTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UXR3</accession>
    <name>A0A1H5UXR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase involved in cellulose biosynthesis, CelD/BcsL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79859">
        <property type="protein sequence ID" value="SEF79859"/>
        <property type="gene ID" value="SAMN04489712_10281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="153"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF79859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="363" mass="40819" checksum="03FC2D077DD518C8" modified="2017-01-18" version="1">MKITVIRPAELGASEIARWREIQQTDPELGNPFLAPEFTLGVARFRPRVRVAVVEEGDKVTAFFPYERGRAGIGHPVGFGLTDLQGIIAPPDLELDARRLLKECRLGVWDFNHLLAHQSAFAPFHTVRRVEPVMDLRDGFEAFITEARNAAPKTHKTVRYKERKLAREVGEIGYVFDCRDEAELTRLMAWKSDQYNRTGRTDRFARPWIVELVRHFHRTGFGVLSILYAGQRPVSAHFGLRDGAVMAGWFPAYDTRFAKYSPGMIGHLRLAQGCAEAGITEIAMGRGGKEFKEGLKGREIPIAEGRVALPLSRHGGGAALHWVRTAPLNRARTAALGNRRLYDLADRALRTYARLRPARTGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UYX8</accession>
    <name>A0A1H5UYX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase YjhB, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80295">
        <property type="protein sequence ID" value="SEF80295"/>
        <property type="gene ID" value="SAMN04489712_10295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF80295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="30689" checksum="61EF5568E28C62F0" modified="2017-01-18" version="1">MGDGDGWARCAKGHQHWGRNGAAGMLIFHRHPEEGTHVLLQQRAWWCSGALTWCLFGGGRHGGEDAVSAALRETTEECTLDTASLRLHGMTVDDHGGWSYTTVIASAAQMPEVLPASSETRRALWLPLEKVDGLRLFQPFALAWPMLATMMSRLVLVVDAANVVGSRADGWWRDRAGAAARLRDELASLAARGVTGLPEDVVGHDTSFPEIVMVVEGAARSVAGTQVPGVRMVAAPGSGDDAIVDLVGAPEPDTVYLVVTADRGLRERVTAAGARTVGPGWLLSRLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VDM4</accession>
    <name>A0A1H5VDM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_102261</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84948">
        <property type="protein sequence ID" value="SEF84948"/>
        <property type="gene ID" value="SAMN04489712_102261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="12">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="13">
        <location>
            <begin position="325"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="995"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEF84948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116482" checksum="6157A6AAA711C537" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VE77</accession>
    <name>A0A1H5VE77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Act minimal PKS acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85553">
        <property type="protein sequence ID" value="SEF85553"/>
        <property type="gene ID" value="SAMN04489712_102284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF85553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="9933" checksum="6ABA7F3D3753180E" modified="2017-01-18" version="1">MGDHEELTLPDLRRILREAAGVNEGTDLDGEILDLDFEDLGYDSLALLETGARIEREYGVRLEDDAITSARTPRALLTVVNLTFTDIDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VE91</accession>
    <name>A0A1H5VE91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_102277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85366">
        <property type="protein sequence ID" value="SEF85366"/>
        <property type="gene ID" value="SAMN04489712_102277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="3"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="122"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="512"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF85366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="603" mass="63921" checksum="C0116C58834948B1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VL11</accession>
    <name>A0A1H5VL11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87959">
        <property type="protein sequence ID" value="SEF87959"/>
        <property type="gene ID" value="SAMN04489712_102362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF87959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13746" checksum="F5EB0AE6E65F8A14" modified="2017-01-18" version="1">MNPPTQPPWERSPADDEQFVRPYVLTSGRISPAHGRFDLITQVVTVGPTPPPDSGLGPEHLSILRLCQDVVMSVAEIAGHLNLPGVTVRVLLGDLLERGHVAVQEPTPEADVTDIGIYEAVISGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W6W0</accession>
    <name>A0A1H5W6W0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95150">
        <property type="protein sequence ID" value="SEF95150"/>
        <property type="gene ID" value="SAMN04489712_102611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF95150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="557" mass="55911" checksum="F3E65A84B871041A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WBR8</accession>
    <name>A0A1H5WBR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ORF">SAMN04489712_102657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96830">
        <property type="protein sequence ID" value="SEF96830"/>
        <property type="gene ID" value="SAMN04489712_102657"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="234"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="199"/>
        </location>
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        </ligand>
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        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="263"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="342"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF96830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="476" mass="51937" checksum="B43DBDD55E390B7E" modified="2017-01-18" version="1">MDYKVADLSLAEFGRKEIRLAEHEMPGLMAVRREYADAQPLRGAKIMGSLHMTIQTAVLIETLVALGADVRWVSCNIFSTQDHAAAAVVVGPEGTVEDPKGVPVFAWKGETLEEYWWCTDQALSWPDGTPPNMILDDGGDATLLVHKGAEYEAAGAVPTAGEGDPEEWGIILETLRRTIAERPGRWTETAAAIKGVTEETTTGVHRLYEMAKNGTLKFPAINVNDSVTKSKFDNKYGCRHSVIDGLNRATDVLIGGKVAVVCGYGDVGKGCADALRGQGARVIVTEIDPICALQAAMDGFQVTTLEDVVDIADIFVTTTGNFNIITAEHMGRMKHQAIVSNIGHFDNEIDMAGLARIPGIEKIEIKPQVHEWRFPDGHSIIVLAEGRLMNLGCATGHPSFVMSNSFTNQVIAQIELFTKTDQYPVGVYVLPKHLDEKVARLHLDALGVKLTKLTKEQAAYIGVDVEGPYKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WBU6</accession>
    <name>A0A1H5WBU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96863">
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        <property type="gene ID" value="SAMN04489712_102658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF96863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="13707" checksum="5A88B0AC3CF12CFB" modified="2017-01-18" version="1">MRITEAARRLGTSPRMLRYREALGLLPPTRERSGHRRFGEAELRAVAYALALEKRYDISPAELAFGLRVLAEPEVQARVRELGERIGRLSAPPARALDFEKEKALRLLRRQPPPSPVNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X805</accession>
    <name>A0A1H5X805_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07881">
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        <property type="gene ID" value="SAMN04489712_103132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG07881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="198" mass="22070" checksum="3270B105104F7EBC" modified="2017-01-18" version="1">MTSKRHKQTDDDALLDAARDCVLAVGVRRTTLTDIARRAGVSRMTLYRRWPDVRSIVADLMTREWTGLAVEVSATARHRGTGSARERLVDHLSEGVRSFRAHPLLRKIVDVDPELLLPYVLQRRGTSQEAFCALLAAGLRAGHADGSVRPGHPVRQARTLLLIAQSFALSVPTMVDDEHTTDAFDAEFREILERVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XAD8</accession>
    <name>A0A1H5XAD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08307">
        <property type="protein sequence ID" value="SEG08307"/>
        <property type="gene ID" value="SAMN04489712_103149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG08307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="22684" checksum="894DAF1C2E77C840" modified="2017-01-18" version="1">MDRPVLPLLGSPRAARADAVRNRRQLLATAREMLAEQGVARLTMDALAERAGLGKGTVYRRFGTRAGIFQALIEDDEHAFQERVLSGPPPLGPGAPALDRLIAYGRARAAFLIEHREIVRAAIDGRRPVPAGTEMRLSQMHIRMLLTQIPLDGADLDILAVQLTAALEAPLLLYLSAADFTDDALHTQERTARGWQDLVQRVCRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XJV5</accession>
    <name>A0A1H5XJV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium uptake protein, TrkH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_103277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11690">
        <property type="protein sequence ID" value="SEG11690"/>
        <property type="gene ID" value="SAMN04489712_103277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG11690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="456" mass="48409" checksum="3C1D7EDBDBC814B4" modified="2017-01-18" version="1">MSLLPRRTPLTSALLSRFRHPAQLIVGGFAAAITLGTVALMLPAATTSGDSAGLLRALLTATSAVCVTGLVTVNVDPHWSGFGEVVILALIQAGGLGIMTLATLLAVLVSGRLGLRARLLAQAETKTLHGTDVRRVIRNIVLFSLVSEAVLALVLGLRFALGYGEPPGRAAYLGIFHSISSFNNAGFALWSDGMMRFVADPWVSLPVAFAVILGGLGFPVVFELARAWRRPRTWSVLTRITVGMSVVLLAGGTLLFTAVEWDNPRTLGPLSDQVKIMAGFFTAVMPRSGGLNVIDISQMRPESWLATDILMFIGGGSAGTAGGIKVTTFGLLAFVMWAELRGEDRVNVGHRRVAGPVQRQALTIALLGVGLVAAGTFLLMFITPHSLDRVLFEVISAFATVGLTTGITPELPAAGQVLIIILMFVGRVGPLTIFSALALRERTRRYELPEERPIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XTQ6</accession>
    <name>A0A1H5XTQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PucR C-terminal helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14646">
        <property type="protein sequence ID" value="SEG14646"/>
        <property type="gene ID" value="SAMN04489712_103388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="167"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="325"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG14646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="42539" checksum="A00C9FE9B67E5D69" modified="2017-01-18" version="1">METTSEDTIRAATTKRLEQAMGTFGTQALASMEQRLPWFRRMPPDQRSWIGLVAQAGIAAFVEWFKNAEGTRPAIAGEVFGTAPRELLRSIKLKHTIDMIRVIIDVVETRLDELAAPGGQAQLREAILRYTRDVAFGAAQVYAQAAETRAAWDARLEALVVNAVLRGEVDDGMHSWAAALGWTAKPVTVVAGYTPPDEEPEVTIDQMQLAARRGRVDVLAGVQGNRVIVIVGGAEDPMEAARPIAAKCGPGPVVIGPLVADLYESSISAQAAMAGLRAAAGWPDAPRPALAVELLPERALDGDESARRHLVKKVYEPMCTAGAPLLDTLTTYLEQGSSLEATARLMFVHPNTVRYRLRRVTELTGLAPTDGRNAFTLRLALVLGRFAERRAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YRU0</accession>
    <name>A0A1H5YRU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26207">
        <property type="protein sequence ID" value="SEG26207"/>
        <property type="gene ID" value="SAMN04489712_104124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="13152" checksum="4A29E9583FE2ACDF" modified="2017-01-18" version="1">MTWRPDDRGSSSVTIAIIFPAIATLFLALAQAVMVSVARDVAQAAAEEGLRVARAHRGSHATGRAAAGGFARREPVLLNPAVSVSGATTITVRVTGHAPTVLPGMRIAVSRTARGARERFTTPQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YTZ7</accession>
    <name>A0A1H5YTZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase / D-alanyl-D-alanine-endopeptidase (Penicillin-binding protein 4)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27683">
        <property type="protein sequence ID" value="SEG27683"/>
        <property type="gene ID" value="SAMN04489712_104190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290919" evidence="2">
        <location>
            <begin position="24"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG27683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="462" mass="47330" checksum="24E6DDBDB8C66F42" modified="2017-01-18" version="1">MPRRERIVAVITLCLLQVCTAGAGVAVIDLTPRHRVAPRPPAVAARTPVQVTAPMPGTDPDAPVPSAAVLTERLAALADGPGPKIGAVVIDAETGRTLFDRDARRPATPASTTKLVTSVAALSALGPDHRITTRVVRGGTEEAVVLVGGGDPTLTARTPAYGAYPQYASLDDLARQTADALKKAGVARIRVDYDTSLYEGGSTAEGWKPNYLPDGEVAPMSALTVDEGRTRLGEQTRVSDPAASAARTFARMLDRHGVPAKAGRRTVAERAAPTLGAVQSPPVSALVEHLMTVSDNDVAEALLRQVAVKRNRPASFEGGSQAVMAELARLGVAEGVRVNDGSGLSTRNRITPLALARIASLAASGAHPELRAAITGMPVAGFTGTLSAPRYTGPGTAAGAGVVRAKTGTLSGVSTLAGLVQDADGRLLAFAFMLGDGEGPVDRGRLDLLAAAVAACGCRTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YV40</accession>
    <name>A0A1H5YV40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27844">
        <property type="protein sequence ID" value="SEG27844"/>
        <property type="gene ID" value="SAMN04489712_104197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15865" checksum="031E96D9438B61BE" modified="2017-01-18" version="1">MKQADLAKVEEANAEFYAAFENGDLDRMSAVWADGPHAPNVGCVHPGWPLLRGREEVLRSWALIMANTPYIQFVLTDLHTVVYGDQALVTCSENIITVDDSADAPGGLAGGSIVATNLFLRVEGRWRLLHHHGSPVLNQAEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YY78</accession>
    <name>A0A1H5YY78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29183">
        <property type="protein sequence ID" value="SEG29183"/>
        <property type="gene ID" value="SAMN04489712_104256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016676">
        <property type="entry name" value="P_lipid/glycerol_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016753">
        <property type="entry name" value="P_lipid/glycerol_ac_tran_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="97"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG29183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="33380" checksum="BCAAB9293634CE61" modified="2017-01-18" version="1">MKHGFGEFAEEQPMAPVIPLNTGAGEPPPGNGSLEDRLAAGLSFLRRRLAGDYEVDEFGYDPELAAGVLLPLARALYEHWFRVELRGLENVPADGCALIVANHSGTLPIDGLMLQVAVHDHVGRDLRLLGADLVYQVPVLGHLSRKAGHTLAHPADAARLLGKGELVGVFPEGFKGVGKPFRERYRLQRFGRGGFVETALRAGAPIVPCAIVGAEEIYPKIADLRALARLLGLPYFPITPTFPLLGVLGLVPLPSKWLIRFGEPMPMDGYGPEDADDPMTVFNLTDHVRETIQQTLYDTLLERGPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z3N4</accession>
    <name>A0A1H5Z3N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_104331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30941">
        <property type="protein sequence ID" value="SEG30941"/>
        <property type="gene ID" value="SAMN04489712_104331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG30941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="18566" checksum="2828F27F8F4572B4" modified="2017-01-18" version="1">MTRRSVTRQYPEVQPDLPPRSRGVIALLEENCTVCMLCARECPDWCIYIDSHKETLPAEGGGRPRTRNVLDRFAIDFALCMYCGICVEVCPFDALFWSPEFEYAEYDIAELTHEKDRLREWMWTVPPPQAHDPAAETPKEVTVAERAAQRAGPAAGRGPGRNGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z559</accession>
    <name>A0A1H5Z559_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">SAMN04489712_104369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31643">
        <property type="protein sequence ID" value="SEG31643"/>
        <property type="gene ID" value="SAMN04489712_104369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG31643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="54" mass="6594" checksum="79EFFC3ECECE6808" modified="2017-01-18" version="1">MAATDVRPKITLACQECKHRNYITRKNRRNDPDRLELKKYCPNCRCHRPHRETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZGX1</accession>
    <name>A0A1H5ZGX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35709">
        <property type="protein sequence ID" value="SEG35709"/>
        <property type="gene ID" value="SAMN04489712_104557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG35709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="963" mass="104948" checksum="37EE2D2EF19126D6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZXC9</accession>
    <name>A0A1H5ZXC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SLATT_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40435">
        <property type="protein sequence ID" value="SEG40435"/>
        <property type="gene ID" value="SAMN04489712_10534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025325">
        <property type="entry name" value="DUF4231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040884">
        <property type="entry name" value="SLATT_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14015">
        <property type="entry name" value="DUF4231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18181">
        <property type="entry name" value="SLATT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_1" evidence="3">
        <location>
            <begin position="178"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG40435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="312" mass="33180" checksum="A3BC4CEBB9A09AA7" modified="2017-01-18" version="1">MTGRSPEDSAPSPPRPRPDDDGIATAARVWRRQSQWSQAAGRLKAGIGRARLAGLLLGTAAAVLGTAAAQLMGWNAPLGKGLAFGSAAAAALVPIVVRGARPETVRDWTRLRSISEALKSEVYVFLAGAGPYRGPDRAVLLLERTDRVQADGSDLTRHLTGLEPVRRELPDITGIGGYVTRRVEAQLDGYYRPGARRMRRRVTAVRRIEIALGALGAVLGALAGAFAVAQAAAWVAVATTVAVAVATHSAASRYEYQELEFSRTADQLERLLARRTAMGGGDPEADDEFVAECELVISAQNEAWMAKVSGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A5V4</accession>
    <name>A0A1H6A5V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44123">
        <property type="protein sequence ID" value="SEG44123"/>
        <property type="gene ID" value="SAMN04489712_105234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG44123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="187" mass="19334" checksum="54BC7E60DCDB828F" modified="2017-01-18" version="1">MTATAARGPSKDTPPATSGGPGSRRAGRRSAATVTGRGGVVIIFALGLLGALLSRWLGVGLLAGLGFMAGCVLAALATRPADLLSLSVCPPLLFLGLTLLAEILTTLGEESLLRGVLVGMVTSLATTAPWLFLGTALVVAIAIPRGLPAAVRDLRDRLAGSRILQEDENEDPVRWDESPRLHHGEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AA66</accession>
    <name>A0A1H6AA66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44636">
        <property type="protein sequence ID" value="SEG44636"/>
        <property type="gene ID" value="SAMN04489712_105262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15695" checksum="6E2FA05D636C9A4A" modified="2017-01-18" version="1">MGKGKEGKGEERISPRARAREARRWLHRNYGLTDDEADAVITEAERRAPNPITHLVPYLAGMADRGDLADIVAAVQATTEPPDTPDPTEPGPAPDPAPASTEPACPRHPHGAAIDPNPPTGWGNCLICNTHRHRANRRERQGAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AB39</accession>
    <name>A0A1H6AB39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44966">
        <property type="protein sequence ID" value="SEG44966"/>
        <property type="gene ID" value="SAMN04489712_105280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="16085" checksum="1F85083A27E11C8B" modified="2017-01-18" version="1">MIIISHKCLVAGCPETSHKWEWNGQPTLRELLYVQETLGMEPAEYREALNSAMTGLTTAGIKAALMMVHLLHRRDGILTPFEDVDLDPTQLETILDPAPDDPAESEGKGTGTPTTPSRPLDDATSSTSGPAAEEGSEPRSSTTPPTSGGGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AD93</accession>
    <name>A0A1H6AD93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46703">
        <property type="protein sequence ID" value="SEG46703"/>
        <property type="gene ID" value="SAMN04489712_105378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292579" evidence="1">
        <location>
            <begin position="28"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="423" mass="44672" checksum="4D60E7F612081683" modified="2017-01-18" version="1">MRRRVTVTAMAATLAFTGAISPPHATADIKHSAVVTANPIDRTPHVLDGTVRAIAVVGGKVIVGGNFTKVREASSKTEIARKNLFAFDFATGKIDTKFKPSVNSTVYALQTGDNNTVYAAGGFWIVNGVQTGSLVKLNVPSGSTVTAFKPNVGGGLVYDIKRHGSRVYLGGMFTKVRGVARNTLARVDATSGAVDTAFDIKPSDPRAGDLKVYKMALNPAGTRLLINGTFTRVNGQRRVQIAMINTSTSPAGLSSWATERYAATCNINAFHTYMRGMDFSPDGSYFVVVTTGGPYGNVTLCDTAARWETDRSGGGQQPTWVNWTGGDTLLSTAVTGAAVYVGGHQRWHDNPLGSDFAGPGAVSRPGIAALNPTTGKALSWNPTRTRGHGVEALVATSQGLFVGSDTDQLGKEYHGRIGFFPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AG58</accession>
    <name>A0A1H6AG58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_105439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47759">
        <property type="protein sequence ID" value="SEG47759"/>
        <property type="gene ID" value="SAMN04489712_105439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG47759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="260" mass="28111" checksum="4C9C49312593AD37" modified="2017-01-18" version="1">MRLDLTGIDAEIDSRPILTDVHLSAAPGDFVALIGPNGSGKSTLLRTVYRALRPTGGVVRLDGADLWGMPARRAARHRAVLTQHSDADVDFSVTELVTTGRIPHKRLLERENETDRAIVEHCLDRVGMRWAADRLVSTLSGGERQRVLLARALAQQAPLLVLDEPTNHLDVRAQLDLLDLVRSLGLTVLAALHDLDHAAAYADHVVVLSKGRVVGHGPPLDVLTPAFIEEVFGVRAHVDVHPLTGRPHIALASLAPQAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AV31</accession>
    <name>A0A1H6AV31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52529">
        <property type="protein sequence ID" value="SEG52529"/>
        <property type="gene ID" value="SAMN04489712_10637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045788">
        <property type="entry name" value="MobC_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19514">
        <property type="entry name" value="MobC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="15437" checksum="64F7C9C9E811B4EE" modified="2017-01-18" version="1">MSGSEDQDERRRAHRQVRKQGQRRKRIMQVRVGDEDLAVISAGATREGLTRSAFVIKASLARARGDTTQTDPVLRDIHEELKDAARKANSIGVNFNQVVKKLNATGHPTGDIPAYSEAAFQAVRRLDAVAVKLWRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWR5</accession>
    <name>A0A1H6AWR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52774">
        <property type="protein sequence ID" value="SEG52774"/>
        <property type="gene ID" value="SAMN04489712_10653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="48" mass="5528" checksum="F6C4036ABAA057F7" modified="2017-01-18" version="1">MPTHSYHVESKSVIKIGVPTWRALAVHGRWADVQKQNVRFLNISRKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B812</accession>
    <name>A0A1H6B812_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56545">
        <property type="protein sequence ID" value="SEG56545"/>
        <property type="gene ID" value="SAMN04489712_106320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG56545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="302" mass="33806" checksum="7AC612BCA9CE2A68" modified="2017-01-18" version="1">MISTTVNDGSGRAPAEPDPAGPLIARMVLGARLRELRESRGISREQAGRTIRASSSKISRLELGRTGCKLRDVTDLLDLYDAERSERSTLLALVERANAPAWWQAYHDIVPHWLRAYLSAEQTASHIRCFEVQFVPGLLQTEDYAREVIRLDHAAVPAPELARRLELRMGRQRILTRRSRPVNLWAVLDEAVLRRPIGGPATMRGQLERLVEVCRMPNVTVQIVPFAAGGHAAAGGSVTLVRLPHPDLQDTVFLEQLDSAVYPDRPAEIDYYWQAFHTLVTEAEPPDRTPEIIESVLADYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BH33</accession>
    <name>A0A1H6BH33_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureG</name>
        <name evidence="6" type="ORF">SAMN04489712_10799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59934">
        <property type="protein sequence ID" value="SEG59934"/>
        <property type="gene ID" value="SAMN04489712_10799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG59934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="220" mass="23031" checksum="E8FE2127A352AFF0" modified="2017-01-18" version="1">MGAFHGDDPHTAPDTGGRALRLGIGGPVGSGKTALTAALCRTLRAELSLAVVTNDIYTTEDADFLRRAAVLSDDRISAVRTGCCPHTAIRDDISANLDAVEALEHRHGPLDLVIVESGGDNLTATFSRGLVDRQIFVLDVSGGDKVPRKGGPGVTTSDLLVINKTDLAPLVGADLAVMARDAAAVRGDRPVLFTSLREEPGAPAVADWVRGLIHHRHPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BM11</accession>
    <name>A0A1H6BM11_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pnp</name>
        <name evidence="10" type="ORF">SAMN04489712_107235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61692">
        <property type="protein sequence ID" value="SEG61692"/>
        <property type="gene ID" value="SAMN04489712_107235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014069">
        <property type="entry name" value="GPSI/PNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02696">
        <property type="entry name" value="pppGpp_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="651"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="728"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG61692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="776" mass="83886" checksum="8DD8FCEEF4645596" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUD6</accession>
    <name>A0A1H6BUD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCP-2 sterol transfer family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64279">
        <property type="protein sequence ID" value="SEG64279"/>
        <property type="gene ID" value="SAMN04489712_10810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="113" mass="12861" checksum="6FB7D2CBEBFDE2F5" modified="2017-01-18" version="1">MANEEECRTALDVIRTRVEKIHPDRFAEHVVERTIVCRISDLGLTLRSTIHEGGLDPFEPTDDSRDAQVRLTVSSDDLVALARDELHAGRAWATGRLKVEASFRDLLRLRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXR1</accession>
    <name>A0A1H6BXR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65432">
        <property type="protein sequence ID" value="SEG65432"/>
        <property type="gene ID" value="SAMN04489712_108105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019283">
        <property type="entry name" value="DUF2330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10092">
        <property type="entry name" value="DUF2330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294251" evidence="2">
        <location>
            <begin position="22"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG65432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="354" mass="38568" checksum="1F7C90FB6CF57D4E" modified="2017-01-18" version="1">MRVLARLSALVCLLVAWTAVGLVRPSWSCGCGAMVTSDSADLLVGQETSIVRYDDRTRTEHIVMRLSVRSKARDAAWLFPTPSTAEVKLGERSWFEQLDRLTEPKVVKRRHWWGRPGGGLVGGDGSSAGAPPGGVAVLGEQRLGPFQVATLAADDSRALAGWLERNGYRLSDRLADGLRPYVRMGWKYVAVKLAPGAGGRLNGDLDPLHVSFRSDEIVYPMRLSRLASNDQAVHLYVLGAHRVAHHGPRGHAFGVTFAGWVEPRQVAAPGLRDFLGGRLFLTEVINQRLAPDVIDDDFRYRYTEDLTHREVRYEDEYLTVLGVPAGYAIVLGALGGVAVVVAGVIAVRRRGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYB0</accession>
    <name>A0A1H6BYB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdhD</name>
        <name evidence="4" type="ORF">SAMN04489712_108122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65633">
        <property type="protein sequence ID" value="SEG65633"/>
        <property type="gene ID" value="SAMN04489712_108122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG65633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="28870" checksum="D2FB27363B87530B" modified="2017-01-18" version="1">MGRVTVRRPVLRLKTEGEPIRRPDTLAVEEPLEIRVGGRPLTVTMRTPGDDFDLVAGFLAAEGIIGGPRDLVAMRYCADTAEQNVLDVALAEGVRPPGTLAERAFQTTSACGVCGKQSIEALRARSPYELAADAVRVDPRVLARLPDRLREAQRVFERTGGLHAAGLFDASGELLAVREDVGRHNAVDKVVGWALRADLLPLSGRILMVSGRASFELAQKAVQAGIPVLAAVSAPSSLAAQLAEETDLTLVGFLRGESMNVYAGARRIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZM4</accession>
    <name>A0A1H6BZM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-related amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66150">
        <property type="protein sequence ID" value="SEG66150"/>
        <property type="gene ID" value="SAMN04489712_108168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="21755" checksum="38E774526EF2F7E9" modified="2017-01-18" version="1">MTQAPTQGRTALLMLDYQVALCERGEHMRMPPLVEQIERRDVLAVAERTLAAARDAGLYIVHVRLAFDPSYELRTNRTARFDVYPRERAMLRDAPGARIVSALAPLPAEPVVDKGGVGAFTGTPLLEMLLGAGVRHIVLGGVATNLVVESTARHAADSGLAVTVLEDMCASFDPELHDVAVRRILPMFAAVRTAAEFAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZW1</accession>
    <name>A0A1H6BZW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Allantoin racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66173">
        <property type="protein sequence ID" value="SEG66173"/>
        <property type="gene ID" value="SAMN04489712_108170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG66173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="28532" checksum="0F57E71EBA9EE2F5" modified="2017-01-18" version="1">MRIWHQSFTVLDDVPHYRDALHRHLNAAARPGTTVELHGMAEGTYPGSYPGVHIGHLYLTNLHREQFVRAALRAEAEGYDAFFIATIPDTGFEEIRSLVDIPVVAFGNASVAFAATLGSRVGIVNFIAELEPQLRRNMDAYGLGSIVGPIVQVEAGFTDVMAAYADPGPLLAAFERAARRAIAEGANVIVPGEGPLNVFLAGQGVSRVDDVPVIDSLGTGLALAETRALLYRRTGLRPPRTGLYFSKPDPRMLAAARAFYYGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C0B4</accession>
    <name>A0A1H6C0B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66352">
        <property type="protein sequence ID" value="SEG66352"/>
        <property type="gene ID" value="SAMN04489712_108185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="312" mass="33717" checksum="B2DDF412FC9B19DA" modified="2017-01-18" version="1">MEQRHLGRSGLVVSRLGLGTMTWGQETAPEEAAAQLAGFADAGGTFVDTADVYGDGDSERVLGRLLREVVPREELVISTKAAIRPDGRYDCSRRHLLAALDASLDRLGIDHVDLWQLHVYDPATPLEETLSALDEAVASGRTRYVGVCDYAGWQLAKAAAWQRAWPGRAPIVSVQTEYSLLHREIERETAPAAEDAGVGILPWSPLGRGVLTGKYRTGIPADSRAATTRYAEFVRPYLGEQSRLIVESVTTAAEGLSVSPLAVALSWVRDRPGVVAPIVGARTPAQLLGILETEEVTLPDEIRDALDDISDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CF68</accession>
    <name>A0A1H6CF68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_109228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70986">
        <property type="protein sequence ID" value="SEG70986"/>
        <property type="gene ID" value="SAMN04489712_109228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG70986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="625" mass="66223" checksum="65C8934EC081144D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CL24</accession>
    <name>A0A1H6CL24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SAMN04489712_110133</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73622">
        <property type="protein sequence ID" value="SEG73622"/>
        <property type="gene ID" value="SAMN04489712_110133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="172"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="297"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEG73622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="383" mass="42342" checksum="DBB48BF8FD388501" modified="2017-01-18" version="1">MQLRYNFRLYPTPGQRQALAKAFGCARTVFNDGLRTRQEARAQGLPYISDGELSKRVITEAKKTPQRSWLGEVSAVILQQALADLNQAYRNFFSSATGKRKGPQVAPPRYRSKRDNRQAIRFTRNARFQVTAGGKLRLPKIGDIPVRWSRDLPSAPSSVTVIKDAAGRYFASFVVEVGDEPLPQTASEVGIDLGLTHFAVLSDGRKIDNPRFLRRAERRLKKAQQALSRKEKGSNNRKKAVVQVARAHARVADARRDFAHQLSTRIIGENQAVVVEDLSVKGLARTKLAKSVHDAGWAQFTAMLAYKAARHGRTLTRIDRWFPSSKLCSTCGTLAESMPLNVRSWTCPCGAVHDRDVNAATNILAAGRAERLNACGGTVRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLB4</accession>
    <name>A0A1H6CLB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="11">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DHOdehase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrD</name>
        <name evidence="13" type="ORF">SAMN04489712_11085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="11"/>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73226">
        <property type="protein sequence ID" value="SEG73226"/>
        <property type="gene ID" value="SAMN04489712_11085"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="12">
        <location>
            <begin position="50"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="322"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG73226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="360" mass="38342" checksum="0786469B06B0253F" modified="2017-01-18" version="1">MYRLLFALVIARIPAEAVHRATLRALRLLQSAPGLARLLRRLLAPRDPALTVRALGLEFPGPLGLAAGFDKDAEAYEALGAFGFGHVEIGTVTGQGQPGNPAPRLFRLPADRAIINRMGFNNHGSQAAAARLRARRPGTVVGVNIGKTKAVPEEQAVGDYVASARRLAPYADYLVVNVSSPNTPGLRNLQAVEQLRPLLEAVREAADAASPGRRVPLLVKIAPDLADPDIDAVADLALDLGLDGIIATNTTIAREGLRSGPELTAQTGGLSGAPVKARSLEVLRRLRGRVGDRLVLISVGGVETADDVWERLRAGATLVQAYTAMIYGGPLWAHQVHRDLSRRLRGSAFRTLQDAIGPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSB2</accession>
    <name>A0A1H6CSB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75922">
        <property type="protein sequence ID" value="SEG75922"/>
        <property type="gene ID" value="SAMN04489712_11198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="52" mass="5710" checksum="CFF907BDEF0DCA9E" modified="2017-01-18" version="1">MKALLTRLAAHHARVQASSVVFHERGGEVCTRACRSAAHRDRVTTAALRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVU0</accession>
    <name>A0A1H6CVU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77199">
        <property type="protein sequence ID" value="SEG77199"/>
        <property type="gene ID" value="SAMN04489712_111263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG77199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="14854" checksum="17916551E0285A35" modified="2017-01-18" version="1">MAKYLLLKHYRGAPAPVNDVPMEQWTPEELSAHVQYMQDFAARLEGTGEFVDGQALSPEGTFVRYDGEGRPPVTDGPFAETKDLIAGWIVIDVETYERALELAGELSAAPGAGGKPIHEWLEVRPFLTVLPTITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CWG2</accession>
    <name>A0A1H6CWG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD(P)H quinone oxidoreductase, PIG3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76716">
        <property type="protein sequence ID" value="SEG76716"/>
        <property type="gene ID" value="SAMN04489712_111197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="13"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="33971" checksum="BDEB05634996382F" modified="2017-01-18" version="1">MICMHAIVIREPGEPDVLEWTEVPDPAPAPGEVVIEVAATAVNRADVMQRRGFYPPPPGAPPYPGLEASGRIAEIGEGVTGWQIGDEVCALLAGGGYAERVAVPAGQLLPVPRGLGLAEAAALPEVACTVWSNVFTLARLAPGESFLVHGGASGIGTMAIQLAHAHGARVACTVGSPEKAARCRELGADVTVNYREEDFVAAGPFDVILDNMGAAYLARNVEALNAGGRLVVIGLQGGTRAELDLNALLRKRAAVHATSLRARPLAEKAAIVSAVREHVWPLIEEGRVAPIVDRVLPITEAAWAHRVLEESGHIGKIVLSVPAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D125</accession>
    <name>A0A1H6D125_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79061">
        <property type="protein sequence ID" value="SEG79061"/>
        <property type="gene ID" value="SAMN04489712_112162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="131" mass="14407" checksum="8417F75794ED6B0E" modified="2017-01-18" version="1">MSLTVSDRLLERARRGEVPEDDFVACVRESLPYAWEVISGVAARSRETGDGFADNRVPPPDETSRGQLLRALASDAMRGALERHFGVRLAFQNCHRVAAFVPDAPGHAERYAAFVSPRGQLLNQSPDLVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2D5</accession>
    <name>A0A1H6D2D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79440">
        <property type="protein sequence ID" value="SEG79440"/>
        <property type="gene ID" value="SAMN04489712_112216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="100" mass="11306" checksum="0F236CC402857FAC" modified="2017-01-18" version="1">MTQDRHVTSEGIGKVRAKVVGDLKRMIDEMRTDIDSTDVGPPGFGLLGEIVFGWKYREIQEHCREILGQAGETLDAWGTSLTVIQQNWRNAENANTVQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D433</accession>
    <name>A0A1H6D433_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH2:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80087">
        <property type="protein sequence ID" value="SEG80087"/>
        <property type="gene ID" value="SAMN04489712_11311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="29454" checksum="158B4D70E9B35617" modified="2017-01-18" version="1">MRAVWLKEFGGPQVLVAADAPDPVPGPGQVLVEVAFANITFVETQFRATGAGPFRPDLPMIPGNGVGGVVTAVGKGTDPELVGRRVVTSTGGSGGYAQRVAVDAAGIFPVPEGLGLDAAVALLADGRTAAMLVRAAGPRPGDRVLVEAAAGGVGTLLVQLARAAGARVVAAAGGDRKTALARELGAEVAVDYRAPDWAERVRAAVGGVDVVFDGVGGAIGRAAFDLLDPSAAHGARMLSYGLASGAWADIPEETARERGVTLLNLRPTPEEVRTCTEIVLTEAAAGRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7L9</accession>
    <name>A0A1H6D7L9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-2-oxovalerate aldolase</fullName>
            <shortName evidence="7">HOA</shortName>
            <ecNumber evidence="7">4.1.3.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-keto-pentanoic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-oxopentanoate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:36003"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17153"/>
            <dbReference type="ChEBI" id="CHEBI:73142"/>
            <dbReference type="EC" id="4.1.3.43"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36004"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22624"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:73143"/>
            <dbReference type="EC" id="4.1.3.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 4-hydroxy-2-oxovalerate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.39" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81281">
        <property type="protein sequence ID" value="SEG81281"/>
        <property type="gene ID" value="SAMN04489712_11415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008701">
        <property type="term" value="F:4-hydroxy-2-oxovalerate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07943">
        <property type="entry name" value="DRE_TIM_HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01656">
        <property type="entry name" value="HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017629">
        <property type="entry name" value="4OH_2_O-val_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012425">
        <property type="entry name" value="DmpG_comm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035685">
        <property type="entry name" value="DRE_TIM_HOA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07836">
        <property type="entry name" value="DmpG_comm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03217">
        <property type="entry name" value="4OH_2_O_val_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG81281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="34806" checksum="1AF1AF7F0CA4DBFA" modified="2017-01-18" version="1">MITLVDTSLRDGMSSVSHKFTPDQVGAVARGLDRAGVRVIEVAHGIGIGASSIQYGIAAATDVEYVQAAVTAADRADIAVLYVPGISTLAALDAVRDAGATTVRVATHCTEADCAEQPIRHARDHGMRVMSFLMMSHKLEPAALAEQAAKLDSYGAQVIYVVDSAGALVPGSAGARVAALRDAVHADIGFHAHNNLGVGIGNALAAVEHGATYIDGSLRGLGASAGNAQTEVLAAALERAGHDPGVDVFALIEVAEHVMAPLMVEPQIVDETALLLGYAGLYSTFFHPAKRAAGKYGVPVRELLLELGRREVIGGQEDMIIDVAAELSSRYGARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D819</accession>
    <name>A0A1H6D819_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81228">
        <property type="protein sequence ID" value="SEG81228"/>
        <property type="gene ID" value="SAMN04489712_1142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="47"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="32393" checksum="13F4B7829DD442C0" modified="2017-01-18" version="1">MTRRSSPLPTQGARGGVRVRTVEVNAAGLRLSGLLAVPPASPPKAVIVALHGAGMSAGYFHSQADPAASLLSLAAARGYAALALDRPGYGVSVTELPDGLELDEQAGRIRHALTDYRGRHPAGAGFFIVGHSLGGKLALTVAAGWSGDALLGVDVSGISDRWAVDPAVHRDMNDRRTRPLSWGPLRLYPPGTFRHAMELAAPIPLRELAEIPHWPHRYPDVARRVRVPVRFTFAEYERWWRCDPQTVEAMTARLAAPLVRTERLAEAGHNISLGYAARDYHLGVLTFVEECLGRSETGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9E3</accession>
    <name>A0A1H6D9E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tn3 transposase DDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_114144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81792">
        <property type="protein sequence ID" value="SEG81792"/>
        <property type="gene ID" value="SAMN04489712_114144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002513">
        <property type="entry name" value="Tn3_Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01526">
        <property type="entry name" value="DDE_Tnp_Tn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DDE_Tnp_Tn3" evidence="6">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG81792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="21994" checksum="71DC745B74E9369C" modified="2017-01-18" version="1">MNLKRIATHWPDMLRVAGSLITNQVRAYDLLRMFGREGHPTPLGAAFAEYGRIDKTMHLLALVDPVDDTYRRLMNRQLTVQESRHRLARAICHGGRGQIRQAYREGQEDQLAALGLVLNAVVLWNTRYLDAAVAQLWAEGREIKDEDVARLSPLKDRHINFLGRYLFNIKASGPGQGLRPLRDPGAVEDDEDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAG9</accession>
    <name>A0A1H6DAG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81833">
        <property type="protein sequence ID" value="SEG81833"/>
        <property type="gene ID" value="SAMN04489712_114154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="71" mass="8208" checksum="AA06D91E5892D3FF" modified="2017-01-18" version="1">MFEVSVAWLRRHRVLLPGVRVLERLVASVREQADERLYAVVARQAVRARRACRAGWRSCRWCRPVGGCRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAN1</accession>
    <name>A0A1H6DAN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMI1 / KNR4 family (SUKH-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82391">
        <property type="protein sequence ID" value="SEG82391"/>
        <property type="gene ID" value="SAMN04489712_11519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="38"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="25794" checksum="49CD1F4BDB4D3DF4" modified="2017-01-18" version="1">MVMVDWHEVRRRVRDLAASPLAAKVFGYHGHGFQLDPVLRPDELAELEQQIKVRLPDDYRDFLLHVGRGGAGPFYGVFPVERIDGRWQWVGDGADLTDLDRLDRPFPAEGLDPTVLEALRAEEPDEETFEDIESFDTAYEEWDRRYEAVVWNDARTVGALCLCHQGCALREWLVVSGPERGNIWTDHRVDDEDLSPHREGDLERTSFATWYLSWLKAAEAEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DB21</accession>
    <name>A0A1H6DB21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82419">
        <property type="protein sequence ID" value="SEG82419"/>
        <property type="gene ID" value="SAMN04489712_11523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12946" checksum="A018F69C5D1E9929" modified="2017-01-18" version="1">MATARRPGAYVCGIDAAMDVIGGKWKVLILWALNEKTCRFGELRRLLPGVTEKVLASHLREMEADGLVHRRVYDEVPPHVEYSLTALGISLNEALAPLGAWGREHVLGPQDTHHAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDB3</accession>
    <name>A0A1H6DDB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82466">
        <property type="protein sequence ID" value="SEG82466"/>
        <property type="gene ID" value="SAMN04489712_11530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTAD" evidence="2">
        <location>
            <begin position="109"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="30539" checksum="3F72C5B4CDDEFE57" modified="2017-01-18" version="1">MLLFRILGQLQVSRSCPGHTVPSLAHRGRALLSTLLLADGVPVSQEHLASMIWDVPPKSYRENIRQHVSRLRIALQHTDPELAARMVTVGGAAGPQRAVYAFKVSFGEVDVHVFRHELETARRALAAGERAAALRCLERGLALWRGPAGLNVEGSLLLRSEFDALDEIRLTAREDLIEIRLATALPSHHVLHEVRELVRGHPLRERSHALLMRALYLSGDQVGALCAYRELAARLDEELGVYPAPELQRLHLAILRHDISAISPSPVTGTDLTRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDF9</accession>
    <name>A0A1H6DDF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83497">
        <property type="protein sequence ID" value="SEG83497"/>
        <property type="gene ID" value="SAMN04489712_1166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="33" mass="3912" checksum="A185F2F404916C96" modified="2017-01-18" version="1">MTAKRTTLEEFLRTHKRTRYTFNADSALVPIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DH34</accession>
    <name>A0A1H6DH34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84491">
        <property type="protein sequence ID" value="SEG84491"/>
        <property type="gene ID" value="SAMN04489712_11713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG84491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="44522" checksum="A2F1DB6F1D69897F" modified="2017-01-18" version="1">MTPQEWLRGYALLALRVNRRLVGDEGATVLIYRGPQEWSAQVKAEEPAAPGRLADDAEALLDEPPFEPERARYLRAQVRALRTVARRLAGERLPLPEYAHQCLGIQAHWLPQEVFEEAHARLDRALPRGTGALTERLQAWQAAHTLPLERLDLLPALVDRAVAEARRRTAALVPLPDDEVVDCRLRHGAHFLAAGHYAGERRSTIFINGDLPFNLADLLYVVTHEGHPGHIAESMLKELVLVEEQGRLDQQVRFMLGPSFVISEGLGLHAQDIAFPGDEAQAWLTDNVLAEHGMTPDSSDFAAIHRARNALFGAWANAGFLAAEGRPDHEVTGYLSRWALMSDAEAAAALGSLRAPGMELYTLGYYHGWRLLNTWLDSPDRTTRVRRLLTEQLLPSDLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJ05</accession>
    <name>A0A1H6DJ05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_1186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85447">
        <property type="protein sequence ID" value="SEG85447"/>
        <property type="gene ID" value="SAMN04489712_1186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="8">
        <location>
            <begin position="292"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG85447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="385" mass="40311" checksum="2D8539D260AB50C2" modified="2017-01-18" version="1">MSQPDKGDAAPEDSAPEPPSPDAGGAQNEASGDPHRPPETPSPIPKPAKDEAAPDTGSPPGGENPPGGGSGETRKTVLAAGGANIAIAVTKLVAGLVAGSSAMLAEAAHSLADTLNQLFLLASLRRSERPADRRHPFGYGKERYFWSLIAAVGIFVAGGGYSIYEGVREIISPGEHGEATVAFVVLAFAFLFEGLSLARAVYQVRKEAADRSRPPLDHVRKTPDTTLKAAVLEDSAALVGLTLAAAGLTLREITGSGVWDGAASVLIGLLLVVVAVTLGRSSMDLLIGQSVDRETLRTIHREIADSPGVSSVVELLTMYLGPDELLVAAKVAFWDEISADQAEDIADEIDVRLRDRLPIIRHVFLDPTQLDPARPPGVSAHETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJW5</accession>
    <name>A0A1H6DJW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin-NADP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_117142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85123">
        <property type="protein sequence ID" value="SEG85123"/>
        <property type="gene ID" value="SAMN04489712_117142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="243"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG85123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="332" mass="36023" checksum="AF0DC92962B97FF7" modified="2017-01-18" version="1">MARDHGFHPVRIRRIVQETADTRTYVLDAAFPYRAGQFVTLRACGTLRSYSMSSSPDTDDEFMTTVKRVPGGLVSNWMHDHLAPGDLVEVTLPAGVFCLRETTVPLVAFCGGSGVTPILSLVKSALATTDRQVRVLTADRDADSVIFRSALAELAERYPGRFEVRHHLDAVDGGFVTAERVRDFAGEDRDADFYICGPTPFMDLTERALLDHGVDPGQILIERFGSASGEPADPRPATQETDGTVTIVLAGKRHTVAQHSGETFLESARRAGLAPPFSCEAGNCATCIAQVTEGEAKMRVNNALDDDEVADGWVLTCQGEPVTPHVTVVYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKF9</accession>
    <name>A0A1H6DKF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85694">
        <property type="protein sequence ID" value="SEG85694"/>
        <property type="gene ID" value="SAMN04489712_11861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTRA" evidence="2">
        <location>
            <begin position="115"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="29206" checksum="B3F51E6085B9FF6F" modified="2017-01-18" version="1">MDLRTIRDISAIADPIERARAITRAMTEQQGITEEAARIRRSAIAEAREAGQTLEEIAKALGVTPGRVSQMRKGPVAKAPTPPASQRPPVIVQRALPTDPATRGSVSLFLVEAERQGITPGRKMLYVGLEPAAEHIAACLRVQPDEEVIARRKMMTANDVPVRIATSFFRNDLFGGTRIAEPDFVKPSLQSAIQALGYTFGHAEETLTARPATRFEADTLQLDPGEWVVQVLRASYSSEGTPIHTLETICSANRHIFTIGQVGGLDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL67</accession>
    <name>A0A1H6DL67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_118130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86012">
        <property type="protein sequence ID" value="SEG86012"/>
        <property type="gene ID" value="SAMN04489712_118130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="101" mass="11027" checksum="88169C68CF54B06E" modified="2017-01-18" version="1">MVMTAIPIRELSHHTARCMAVVKAGETVDITERGKIIGRIVPVDPVHDVRARMIAEGRMRPATAGRAALLAAVRRRLAAEPVDAASRGTAALLEMRDDERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLG4</accession>
    <name>A0A1H6DLG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_118132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86019">
        <property type="protein sequence ID" value="SEG86019"/>
        <property type="gene ID" value="SAMN04489712_118132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="713" mass="77065" checksum="034B797D576B9277" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLL0</accession>
    <name>A0A1H6DLL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ORF">SAMN04489712_11867</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85723">
        <property type="protein sequence ID" value="SEG85723"/>
        <property type="gene ID" value="SAMN04489712_11867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="6"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="241"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG85723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="440" mass="47933" checksum="A945DF3E9D83B3F1" modified="2017-01-18" version="1">MYVCGATPQAAPHIGHLRSGVIYDLLLRWLRRTGHEVTFVRNVTDVDDKIIAVAAERGTPWFAVAEANQRVFDQGYDVLGCLPPTVAPRATGHVPEMIVLIRRLIEAGHAYAAGGDVYFDVKSWADRYGALSNQRLDNMRPAGDTPNEDAKRDPRDFALWKGAKPGEPSWETPWGEGRPGWHLECSAMATKYLGPTFDIHGGGVDLIFPHHENEIAQSQAAGDGFARYWLHNGLLTVDGVKMSKSIGNVVLLTDLLDRARPVEVRYYLASAHYRSLMDYTDAALAEAVAAYQRIEGFVTRAAELVDAGSGDGDLPEAFTTAMNDDLGVPQALAVVHETVRDGNSALASGDTDAVVRHLAAVRAMTGTLGLDPLAGPWMGERDEDLRPVVDALVKVALEQRQAARSRKDYAAADEIRDGLAAAGILVEDTPHGPRWELKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLU7</accession>
    <name>A0A1H6DLU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86270">
        <property type="protein sequence ID" value="SEG86270"/>
        <property type="gene ID" value="SAMN04489712_11938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="11446" checksum="4EB9A09FA4411EE0" modified="2017-01-18" version="1">MKIGHVIVPAADVEAQLAFYASLGLTVKFRDGDRYAAITDGRTTIGLADETQQPVAGQTLISIEVDRLDEFVARLPAGEPVTGPHERRVVVTDPCGNPVVLYERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNT8</accession>
    <name>A0A1H6DNT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86874">
        <property type="protein sequence ID" value="SEG86874"/>
        <property type="gene ID" value="SAMN04489712_12024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="16231" checksum="578D129FCD53B6DF" modified="2017-01-18" version="1">MLPTLSGRIQTRLFLLATVGLVVTALIVPVLPGAGSAALGDRYRTGLVVLASVAVLGVCWELLYHFLMQFRWEKDWPTLFGLLTLVPEGLLLWGLLELDVVPGITAGPPAATFWIHFAVVWLAVWLVANGPMRVPFVRWRFRGGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNX8</accession>
    <name>A0A1H6DNX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="10" type="ORF">SAMN04489712_12060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87057">
        <property type="protein sequence ID" value="SEG87057"/>
        <property type="gene ID" value="SAMN04489712_12060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG87057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="523" mass="55591" checksum="098E5645C22847D3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPS5</accession>
    <name>A0A1H6DPS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87154">
        <property type="protein sequence ID" value="SEG87154"/>
        <property type="gene ID" value="SAMN04489712_12078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="10211" checksum="1B1D88C6197AD67C" modified="2017-01-18" version="1">MPIQEPYRQLEELAGRLSREGLCARLDEPLDRPPTLHVINPDMPVAEEHVIVESVSDEAWFWWAWAERIAPAHDIDTAITGIRRVLGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRD9</accession>
    <name>A0A1H6DRD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Immunity protein 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87790">
        <property type="protein sequence ID" value="SEG87790"/>
        <property type="gene ID" value="SAMN04489712_1212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028961">
        <property type="entry name" value="Imm21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15589">
        <property type="entry name" value="Imm21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="129" mass="13852" checksum="816945DC055414CB" modified="2017-01-18" version="1">MTSLPLDLKIQSPRCPHLGGKPRYLPAHRAFLRRLAAGCEADLLTAAEAVLADPATEWQEYGTWRTDGPAVLMDSAEAGAELSVEYPDGGLPDQAPVLLPAGRWAVRGVHTWADDDTWVGLVQLLPAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTE0</accession>
    <name>A0A1H6DTE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88023">
        <property type="protein sequence ID" value="SEG88023"/>
        <property type="gene ID" value="SAMN04489712_12159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="418" mass="45761" checksum="321DD9578F877CB9" modified="2017-01-18" version="1">MTLDQADVPLVRLDPTGADHHGEVARLRAAGPVARVLLPGDIPAFAVTTHDLAVRVLQDRTLSKDWRHWTAAVDGRLADDNPMVGMVKVPPNMVVADGAEHQRLRRPVIQTFTHRRVQDLTGRIRQIVTTTLARLPDHADQSDVVDLRRDLAVEVPVQVICELLGVPGELRPRLRHLVDSIFRTDTTPQQVAATQAEIPHFLAELVAWRTREPGDDLTSAMIADRARGDSSLSEGELAGTLWVLLTAGHETTVGLIGNAVHALLAHPDQLALALAAEDPAVWKSVVEETLRWDPPITNFIGRYPRQDLDLDGVTVPAGEAILISYAAANRDPVQHGPDADRFDITRTPQAKHLAFGDGPHVCVGPHLARLEAEITLHQLFRDRPALKPAEDLATLPRIPSLFTRAWAVLPTRLGDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTR6</accession>
    <name>A0A1H6DTR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88133">
        <property type="protein sequence ID" value="SEG88133"/>
        <property type="gene ID" value="SAMN04489712_12183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG88133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="17605" checksum="749C3789B864E37C" modified="2017-01-18" version="1">MADADVVALLLVRLVVGITMIAHGLNHWRGGGRIEGTARWFGGLGLRHGKLQAWMSVVTEIGAGALLIIGLLTPLACAAVISVMLVAGLLAHRPNGFFVFKDGYEYVLVLAVTSLALAMLGPGKLSVDDAAGIDVTGWAGGGIALGVAVVATAGLLATFWRPQPKEADQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DW57</accession>
    <name>A0A1H6DW57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ORF">SAMN04489712_12365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89314">
        <property type="protein sequence ID" value="SEG89314"/>
        <property type="gene ID" value="SAMN04489712_12365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="18"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG89314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="421" mass="45740" checksum="8D292B8207DE799E" modified="2017-01-18" version="1">MSSSFQAPKGVSEYVPPRAELLRSAREAFAEQARLAGYGYVELAVFEDTQLFKRGVGESTDVVSKEMYTFSDRGGRSITLRPEFTAGVLRAVLEYGLHKQGLPVKVWTTGPAFRAERPQQGRYRQFYQLDLEAIGSEDPQVDAETIAIAWNWYRSLGLTQVRLLLNSLGCRECRPAYRVRLQEFLRGLDLDEATSARVEINPLRVLDDKRPEVRALVADAPLMADHLCVACKAHHDRVRELLADLGIAWEDDPRLVRGLDYYTRTTYEFDHPLLGAQSGIGGGGRYDGLSEDIGGPALPGIGFGLGLDRTLLALEAEGVQPSVPSRCQVFGVPLGEAAERRVFALVAELRAAGIAADMSYGGKSLKGAMKGADRSGAAYAVIVGERDIAAGSAQVKDLGTGEQSAVPLADITATLKERLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY53</accession>
    <name>A0A1H6DY53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89693">
        <property type="protein sequence ID" value="SEG89693"/>
        <property type="gene ID" value="SAMN04489712_12430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="55" mass="5938" checksum="DC32A5F38A4E570E" modified="2017-01-18" version="1">MRNTNSTENVGKKARKGSGPASRFGGVPDRKSAALSRGARPNARRLPTRNMSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYL5</accession>
    <name>A0A1H6DYL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90418">
        <property type="protein sequence ID" value="SEG90418"/>
        <property type="gene ID" value="SAMN04489712_12631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="18607" checksum="F2DD85C9F2EFD391" modified="2017-01-18" version="1">MSTTGYAGHMPLEPDHLSPEEGLTWRSHLRMHALLGASLARRLARDTGLSEADFEVLAALATSPDGRMTSLRVRCTLVWEKSRLSHQVRRMEQRGLITREPNPDDARSSLLALTAAGRAAVEDAFVPYAQHVREHYLDLMTPEERDVLIKVSERVVANLDPLDADDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0M8</accession>
    <name>A0A1H6E0M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91087">
        <property type="protein sequence ID" value="SEG91087"/>
        <property type="gene ID" value="SAMN04489712_12832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="51" mass="5320" checksum="8434E8BDC17B974E" modified="2017-01-18" version="1">MFVRRCGFLAFWLVLALYVLRHPLGAAQTVAAIGSGLASLADALAAFASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2A7</accession>
    <name>A0A1H6E2A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91697">
        <property type="protein sequence ID" value="SEG91697"/>
        <property type="gene ID" value="SAMN04489712_13024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="103" mass="12312" checksum="DFE21359CBCB6504" modified="2017-01-18" version="1">MRERFYPSDLTDEQWALIEPLLPAEHWDGRKEKWPRREIVDAIAYVNRTGCSWRQLPHDHPPWQTVYGYFRLWREEGLFTELSACCTAWCASPRADEPNHRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3M7</accession>
    <name>A0A1H6E3M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain-containing protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92177">
        <property type="protein sequence ID" value="SEG92177"/>
        <property type="gene ID" value="SAMN04489712_13248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="6998" checksum="48B2191214894AEA" modified="2017-01-18" version="1">MTDAPGDFLTVDETAALLKISRWKLYDLLRNGELASFHLGRRRLIPRTAIDDLVNRLMGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E509</accession>
    <name>A0A1H6E509_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92299">
        <property type="protein sequence ID" value="SEG92299"/>
        <property type="gene ID" value="SAMN04489712_1339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="260"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="382" mass="40106" checksum="FB90DE622C361D20" modified="2017-01-18" version="1">MAEAYIVGAVRTPVGTKKGALKDVHSADLGAHVLKELMSRTGVDPAAVEDVIMGCVMQVGAQTLDIARTAWLSAGLPEHVPGVTIDRQCGSSQQAVHFAAQAVLSGTQDLVVAAGVENMAMVPMGSSVPMGPEGPAAGLPWGPGWAERYGKQEISQFRGAQLMCEKWGFKRGDLEQFALESHQRAAKALENGYFDREIAPLGGLATDEGVRPDTTLEKMAGLKPLREGWEITAAVASQISVGASALLLASEEAVKRHNLTPRARIHTLAVCGSDPVYMLTGPIPATEKVLAKSGLKIDDIDATEINEAFAPVVLAWLKEIGADPARTNPNGGAIALGHPLGATGGVLMTKLLHELERTGGRYGLQTMCEGGGQANATIIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E533</accession>
    <name>A0A1H6E533_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron(III) transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92800">
        <property type="protein sequence ID" value="SEG92800"/>
        <property type="gene ID" value="SAMN04489712_13534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="371" mass="40000" checksum="DD8DB512F58B624D" modified="2017-01-18" version="1">MPEINVSALGLDYAAKTAIDDISFTAREGEFLTLLGPSGCGKTTTLMSIAGLVQPTRGSITCGADVLFDSQRSIDRPPERRNCGVVFQSYAIWPHMSVADNVAYPLRLRKVGKAEIAKRVQEALAMVELAALAERYPHQLSGGQQQRVALARAITYGPGVLLLDEPLSNLDAKLREQARIWLKEFQTSVGLTTIFVTHDQDEALALSDRVIVMNDGHIEQVGTPEEIYQRPASPFVASFLGSANLLAGTVLGTAGGLTQVRLQDSGQTVSVGADSLAGDVLVMIRPEDVELFSDTNAADHATLQGTLASRTFVGSSYRYIIDCGGQKLSVASRERWEPGPVRLRFAPERARLFPHASATAVPTLTEELSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E553</accession>
    <name>A0A1H6E553_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92820">
        <property type="protein sequence ID" value="SEG92820"/>
        <property type="gene ID" value="SAMN04489712_13540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="22911" checksum="6A71393F21F203A6" modified="2017-01-18" version="1">MARTHGWRGDQPGDDVEARGRIIEATMRCIDRYGAKTRLADVAKELGVTRQTVYFYFAGTEELLVAAAQHAVGDFLDRLAAHVAPISGDAEILAEGMLHTIQELPNDPYLGILLASGHTGTFTQSITSPTAMALGRMILTRFDIDWTARDYTATDLDELVELMLRLLQSFVIDPGHPPRSPEEFRAYLRRWFSRLLHSPSPATADGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E942</accession>
    <name>A0A1H6E942_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000044">
        <property type="protein sequence ID" value="SEG94232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94232">
        <property type="protein sequence ID" value="SEG94232"/>
        <property type="gene ID" value="SAMN04489712_14419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="195" mass="21640" checksum="115E9583AB55F7FA" modified="2017-01-18" version="1">MPTSSQPFTTFISDEQLRIMERLRWHGEALLLLVNLSLTRPDANGRLLTGTGTLNAMVQPGDWFRELERVDAASYVELLVPVTEDHARATAVRRIRDARGMLREGKNEPAIVSARAALEQVKNTPEVKALSKSAKAKNSRDRTQDERWAMVVEDVYSLACGAAHDDETTESFVYSRQDAEVIIVAIAGLVARYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E977</accession>
    <name>A0A1H6E977_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000047">
        <property type="protein sequence ID" value="SEG94378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94378">
        <property type="protein sequence ID" value="SEG94378"/>
        <property type="gene ID" value="SAMN04489712_1473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296685" evidence="2">
        <location>
            <begin position="43"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="74"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="376"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG94378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="603" mass="65430" checksum="7FDAAA419FA8BF21" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBX4</accession>
    <name>A0A1H6EBX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000047">
        <property type="protein sequence ID" value="SEG94404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94404">
        <property type="protein sequence ID" value="SEG94404"/>
        <property type="gene ID" value="SAMN04489712_14710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004260">
        <property type="entry name" value="Pyr-dimer_DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03013">
        <property type="entry name" value="Pyr_excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="17888" checksum="9CC36BEE6EEEAEA3" modified="2017-01-18" version="1">MQTFLPYPGFAASARVLDARRLGKQRVEAIQVLRGLLVPGYGWRHHPAVRMWTGYEEALVRYGLETCLTWCAAGRADTCAATLLDDLAEATGILDVRTQEELAKAGELPPWLGDPDFHRSHQSSLLRKDPAHYGPFFPGVPDDLPYVWPRSDRTTRTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECV5</accession>
    <name>A0A1H6ECV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000066">
        <property type="protein sequence ID" value="SEG95101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95101">
        <property type="protein sequence ID" value="SEG95101"/>
        <property type="gene ID" value="SAMN04489712_1661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG95101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="15588" checksum="3E8B5D721DF59E8B" modified="2017-01-18" version="1" fragment="single">MRDRRPRVTLQRALSQQTCTAGRRRWGPPPETAAVATANTEVTAVRQACGGAGRNREPAPTVRLVMTEDTPRRGRPLRLLDERVRSELLEAIEAGATIEAACAAAGITSATYRSWMARGRQAQEAEEAGETVPDSEEPFLAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ED41</accession>
    <name>A0A1H6ED41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000055">
        <property type="protein sequence ID" value="SEG94929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94929">
        <property type="protein sequence ID" value="SEG94929"/>
        <property type="gene ID" value="SAMN04489712_1554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="82"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="431" mass="47837" checksum="8C7C5D321FB54DD4" modified="2017-01-18" version="1">MKNGSQDLPWPIIGESSTSSSRHISGIAHTGRIASDISNCLLQDNPDTDALEVDLQSRYSLSPQDASHLIYEAVLNLNQKLFPPIISLELILTEGCNLACTYCFEKEMLGHKKMPLEVAKSAVDLLFSYSGDRPSVTITHFGGEPTLNFPAIQYATEYAEDRAAELGKSVNFNITTNGVLLNERIVGYFADHKIDVLLSLDGSKTTHNKYRVDKRGQGTFDRVLKGLHTLKEQMPWIAAKLTVMPTNASQLYEDVVHLHEIGVNEFLIGHASGVKWGHDDMNIYSRQLRKVFEWYINMESHETLRIPEFDDIESGASFGCRAGNSSMTVSIDGEISPCAKILALDNKSLLSKLGDTRHGLTHLRNRMELVSCKHVRSECEILGIAKDYHGGCFAENYEDNRNLFSPSRQGYDFAVLTRAACSGCNAGSKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EDD6</accession>
    <name>A0A1H6EDD6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000052">
        <property type="protein sequence ID" value="SEG94815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94815">
        <property type="protein sequence ID" value="SEG94815"/>
        <property type="gene ID" value="SAMN04489712_1523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG94815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="21626" checksum="D321374AF0748B9D" modified="2017-01-18" version="1">MRAVRAAGIRDGRVLEAVRATPRAGFVPAGWVGAAYEDMPVPIGHGQVTTQPSLLARMIEALGPGGDEHVLEVGTGLGFQTALLARLAGDVVSVELWADLTEEARGNLAALGIGNVELRTGDGGEGVPDLAPFDAVIVSAAFPEVPPPLVEQLRLGGRLVQPIGPGGQEDVVLFRRTAAGLAPLRVLTPACFVRLHGRYGFPSDDTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SA59</accession>
    <name>A0A1H5SA59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47290">
        <property type="protein sequence ID" value="SEF47290"/>
        <property type="gene ID" value="SAMN04489712_101127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045998">
        <property type="entry name" value="DUF5954"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19379">
        <property type="entry name" value="DUF5954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF47290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="33178" checksum="FEFE494B9C4F7973" modified="2017-01-18" version="1">MTMGDGDAGGRIFPEDLDAVDPVAAVMLADARRSLSTYPDLVVAGPLFAPAEQVPGGWQAVCPCDPLPQGARELLAAHLRNRGAVAGRTAGRDFQEAARRLEDGSCDELSVLARRFRIVRIEQLMRTGADGPEPPRPTDHDPRPPGPGRPVPRRPPDFIADPARDTRGTDDIVTAELLCQYLDEAARHGSEPAEPFLAPVQLAPMFTVAERSGQLWRPGPRLYGLPQEARDSLVTYFRHVVPSVERPDPLELAEYAEAADLMEDGQRRNGIVAAGRRFRIVRVERMVLVGPDGPETPRPSDRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SAW2</accession>
    <name>A0A1H5SAW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR04222 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47128">
        <property type="protein sequence ID" value="SEF47128"/>
        <property type="gene ID" value="SAMN04489712_101122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026467">
        <property type="entry name" value="Ser/Gly_Cys_C_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04222">
        <property type="entry name" value="near_uncomplex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF47128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="309" mass="31252" checksum="B06584A259DE19DE" modified="2017-01-18" version="1">MDALAVDVFAGTGDTWGISGPDFLLIYVAAAIVLLGAALAARRWACRGRPPQGDLDAYELAYLVGGMRRAVAASVAALRAEGAINVARKGKLRDVREPQTSRTELDQAVFAEVRHLDRPGVRQIGNMSKVRAAADRIRDGLVAKGLLAGPAERAQARLATVPLLILLAIGVVRLVAGLQNHRPVWFLVIAMGVVAVVTAVLWLRQPGLLRAGTAALDAARARNAHLNPTVRPAWTTYGAEGAAFGVALFGAAALTGIDPLFAEEAELAKQLAAGSGGGSSSSGASCAGASSCGGGGGCGGGGCGGGCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SM98</accession>
    <name>A0A1H5SM98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="10" type="ORF">SAMN04489712_101277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51743">
        <property type="protein sequence ID" value="SEF51743"/>
        <property type="gene ID" value="SAMN04489712_101277"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF51743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="25273" checksum="2408E4876910ADFE" modified="2017-01-18" version="1">MQNTRGASLNDAQDSQSAAEGPGGFPRPRRIGVLIAVALTALTLDAITKVLVVARLEGRTPIELLDGLLTLRVTRNSGAAFSIGTGLTIVFTTIALGVVVAILRTARNLRSLPWAISLGLLLGGATGNLTDRLLRAPSPMEGHVVDWIELPYFPVFNVADSAIVCGGILAVLLAGRGLQLDGTRVGDTDAGDSADDADATKDAAGNAAEGGAGDATRDAAGDAAGNAVEGGAGDAAADRGADKERRKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SX18</accession>
    <name>A0A1H5SX18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55106">
        <property type="protein sequence ID" value="SEF55106"/>
        <property type="gene ID" value="SAMN04489712_101398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF55106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="26199" checksum="DEF5E1EFF41759C0" modified="2017-01-18" version="1">MVRHLTAVLAAITLALGAAGCGDTGGDDPADRTLTVFAAASLTETFTELGKTFEKAHPGVRVRFSFGGSSTLAQQIVQGAPVDVFAAASPATMRPVSDERLTADAPRTFARNRLVIAVPPGDPAKIRTLRDLAGRELKVVLCAPQVPCGAAAEKALDVAGVKVTPVSQEQDVKAVLTKVRLGEADAGLVYRTDVRAAGGQVEGVEFPESAEAINDYPIAALAKAPQPGLAGEFVDLVLSAQGRAVLTRAGFESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T1W4</accession>
    <name>A0A1H5T1W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56017">
        <property type="protein sequence ID" value="SEF56017"/>
        <property type="gene ID" value="SAMN04489712_101426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF56017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="17920" checksum="D7FA52D99DCAF09A" modified="2017-01-18" version="1">MDLIALEEIRRVKYRYLRCVDLKLWDDFADVFTEDAVAEYDTPVLGKPLRLAGRDAIIGYMRANLGPGTITTHLAGHPEIEIDGDHAQGTWALEDTVIVMAHRLLIRGAAHYEDTYRRCSDGHWRVSATGHKRTYEYTVSLADLPSLSFTANRWASDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T3V6</accession>
    <name>A0A1H5T3V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57480">
        <property type="protein sequence ID" value="SEF57480"/>
        <property type="gene ID" value="SAMN04489712_101473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF57480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="32354" checksum="B4561D777FDBA556" modified="2017-01-18" version="1">MARLLEDKIAIVTGAAHGIGRGHALELARHGARVVVNDLGTTVRGDGTGQDADEVVKLIAERGGTAIADYGDVADERQAQALLDRAVGEFGRVDIVVNNAGIVRDKVIWNMTPEDFDLVMRVHVRGTWLMTHLAAKHWRARAKAGETFTGRVINTTSGAGLVGNFGQTNYATAKAAVVGLTLTASLELYRLGVTVNAVGPGGLTRLTATMGRDLEPFEPDELGADEYHPMDPAGSSPLVAWLASDEAQHVTGQVVRAIHDKIHLMRGWHEAATISSGEKRWDATTLGLQMATDIFGTRAPGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TD77</accession>
    <name>A0A1H5TD77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60041">
        <property type="protein sequence ID" value="SEF60041"/>
        <property type="gene ID" value="SAMN04489712_101552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF60041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="36499" checksum="D766268AD2285367" modified="2017-01-18" version="1">MKIRGAVKTAATLRPPAGGGAGAALAMRDVEVSLPSARGSLRILRGVTFTVGRGEVVAVAGESGSGKSTSILAALRLLPPGARVTGSIVLDGEDVLAMPRRGLRGLRAGRARLVFQDPWRALHPMKRIGAQLVESARTADPGLSAAAARELVEHTLAGVGIPDPPARMRSYPHEISGGQAQRIVIAMALVARPAVLLCDEPTTALDVTTQAQILELLRRLNRELGISIVIATHDLDVIADVADRLVVMYAGEVVEEGPTAEVLSAPRHPYTWSLLRAAPGAAEGGRLRAIEGRPPSPAEEPAGCAFAARCPSVHEICTTTRPEPRHVLPGRASACLRAEGYGPVPAGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TEX4</accession>
    <name>A0A1H5TEX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61385">
        <property type="protein sequence ID" value="SEF61385"/>
        <property type="gene ID" value="SAMN04489712_101593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF61385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="20616" checksum="FEBFD041051A042C" modified="2017-01-18" version="1">MSAVNDEFELRGVNHLALVCRDMKRTVDFYQGVLGMPLIKTIELPMGWGQHFFFDCGGGNALAFFWFPDAPEPVPGVSAPRGLPDRGELLSAVGSMNHIAFDVPAERIEEYRDKLIAKGVDVGVILNHDDSEFGVAPEMHEGVFVRSIYFRDPDGILVEFAAWTRELNSPDDVRHEPRTAADRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TFI7</accession>
    <name>A0A1H5TFI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61595">
        <property type="protein sequence ID" value="SEF61595"/>
        <property type="gene ID" value="SAMN04489712_101600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="211"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF61595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="417" mass="45090" checksum="61CEDC1922F1E454" modified="2017-01-18" version="1">MTLGRPGQTKVDAAIDGWALPARPRAPYGWPVSRRSSRERAAELAYISLGSLVGSLFVFVVYTDPDSQGLPPIGYEAAAAAVFALLALALRRRWPVALAVVCHLGGIVSVAGIGFAAMAVFNLAVHRSWRVTGALATTHLLLIGALWRLDETTNPRDYWEGVLTVALLHIALVAIGLLVRSQRRLVLAAQERARQAEEGQRLRVEEARHHERERLAREMHDVLAHRISLLAVHAGALEYRGNLPEEEARAAKVIRQCAHDALEDLREVIGMLRDDPGDNGERPQPTLTDLPALIEQSRQAGAHVTLRDRIADPPAVPARVGRHAYRIVQEGLTNARKHAPGTHVRVTVEAVPGEGLTVEVANPLPVGGSPAGPTVLPGAGAGLIGLRERVGIVGGRLEHGRTPQGDFRLRAWLPLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TLI0</accession>
    <name>A0A1H5TLI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NitT/TauT family transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62887">
        <property type="protein sequence ID" value="SEF62887"/>
        <property type="gene ID" value="SAMN04489712_101642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009285173" evidence="1">
        <location>
            <begin position="23"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="50"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF62887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="339" mass="36014" checksum="D5C9AFA5F08C720E" modified="2017-01-18" version="1">MRPRGLIIALIPAFLLATAACGGDGETTTTAGGKKLDKVTLTLNWYPYGEHAPFYYGKTRKIYEKHGIDLQIRPGQGSQKTVQATGAGQSDFGWADTPALLAGVGQGVPVKSLGVFLQTTPASLQFFTEKNYRSPADLKGKKIAITAGDALSRTFPVFLKRNGMTDKDVQLQNVDPAGKIAAVISGKADALIGYASDQGPTMQHKAGKPVSYLRYSELGLNFYSNGLLAGNRLITGKPDLAKRMVAATSEAWTAAQSDPQGAVDAMKGASEQLPPPQVLADQFKTTLTLLHTDSTQGKAPGVNTEADWQQTIDVFAQAGMITDPKPPADYWANDAALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TMR4</accession>
    <name>A0A1H5TMR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64152">
        <property type="protein sequence ID" value="SEF64152"/>
        <property type="gene ID" value="SAMN04489712_101684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF64152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="381" mass="40548" checksum="52AC3E930D6B74F4" modified="2017-01-18" version="1">MPATRHLPTPESADLIALTREIAAKELTPRVDAAERTGTFPREVFATLGEAGLLSLPYPGRYGGGDQPYEVYLQVLEEIGAVWASVGVGVSVHALSCFPLLAFGTDEQRARWLPDMLSGTRLGAYCLSEAHAGSDPAAMRAKAVRDGDSYVLNGAKAWTTHGGEADFYTVMARTSDEGARGISCFHVPADTPGLEFDRPEDKMGLMGSTTATVRLVDARIPADHLIGQEGQGLSIALAGLDAGRLGIAAVATGLAQGALDAAVAYAREREAFGKPIIDHQGLAFVLADMDAAVESARATYLAAARLKDAGHPYGRHASIAKLVATDNAMKVTTDAVQVLGGAGYTRDFPVERYMREAKVMQIFEGTNQIQRLVISRHLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TPE5</accession>
    <name>A0A1H5TPE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotriesterase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64663">
        <property type="protein sequence ID" value="SEF64663"/>
        <property type="gene ID" value="SAMN04489712_101699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF64663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="34381" checksum="A2E430CC64F6AC2A" modified="2017-01-18" version="1">MTGAQTAENATVNTVLGPVPAQELGVVSIHEALLSVVPGAEYAFDITLDRAEIFATLAEKLQDFRRHGGGTIVDSTGMFHGRDVRLYEALSRTTGVHIVASTGQGPEEMLGGYFLTPQTDPPTPWPAEKFADLFAKEVTEGMVVPRVERRGAAGLVATAASLAGMTATDESLFRGAARAALTTGVPVSIRYGNDAVRDLRVVLDEKLPAGRVVVGGLDRRDAVAAGAPIKVAALGAYVALDHVGTEDDAHVTDAERAALVAELIEAGHGGRILLSSNATGVAKGHPANEVRYSHVLTAFVPLLKAQGLGDEDVQRILVGNPRDLLSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V336</accession>
    <name>A0A1H5V336_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Osmoprotectant transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80827">
        <property type="protein sequence ID" value="SEF80827"/>
        <property type="gene ID" value="SAMN04489712_102114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF80827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="23927" checksum="1F90B96549ED48B2" modified="2017-01-18" version="1">MNAILGALEWFTRAQQWSGPDGIPARLLEHVWYSLLGFAITVLIALPAGLVLGHVRRGRLAGLTGFLVTSSANAARALPTLGLLILAVILTSAGDLVPILIPLVVLAVPAVLVNTYAGVRQVEPGLRDAAEGMGMRGPQVLLRVELPVAMPLILLGMRTAMIQIISTATIAAYVGLGGLGRYIVDGYARQDYDSMAGGAILVIVLAVATQFVFAGVSRLTVSPGVRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V7M6</accession>
    <name>A0A1H5V7M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83213">
        <property type="protein sequence ID" value="SEF83213"/>
        <property type="gene ID" value="SAMN04489712_102199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009286931" evidence="2">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF83213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="28285" checksum="BE75E4E17AAFB28A" modified="2017-01-18" version="1">MFPRGLAALLLGAGAVTACATGGDPAPPPAPIPTAPPGTSAPPVPTVSPGPSAPGGLVLRWRLTGGIAGVGGPGALPDFSLYGDGRALVPAGGSPLEVREYRLTGDALRRLLDGARTAGLDRGRTVERPRIADAFTLVIRFGSARTRIEHPEEDGDPAVRFWKRLDPRGWPRQDQAVPPRPHRYTRLAVLAGEVTGGTGGPVRRWPLSPLGRGEQAGGGLCTVLDGDDAATATRLGKAAPAGTLWRSEGKVYSVRWRPLLPDESTCRDMAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V847</accession>
    <name>A0A1H5V847_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine-protein kinase RsbW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82948">
        <property type="protein sequence ID" value="SEF82948"/>
        <property type="gene ID" value="SAMN04489712_102189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF82948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="14687" checksum="F6811400D69C1D20" modified="2017-01-18" version="1">MPAEMPADTKAAVRDMVTVKLPADSAYLSVLRTATAGLAARLDFTLDEIEDLRIAVDEACAMLLAQAVPGTDLECQFELTGDAMRIAVSVLTVDGVEPSRDTFAWTVLSSLAGDVDSTVGADDRVTVMLRKRRGAAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V854</accession>
    <name>A0A1H5V854_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_102206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83390">
        <property type="protein sequence ID" value="SEF83390"/>
        <property type="gene ID" value="SAMN04489712_102206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014293">
        <property type="entry name" value="RNA_pol_sigma70_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02947">
        <property type="entry name" value="SigH_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF83390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="236" mass="26318" checksum="4251802FD4912C6F" modified="2017-01-18" version="1">MPSAVAEPAGVAVVPRQRGPISSEAYGGEGVAGTEGVGQVPGTTESVEQRQERFQRDVLPFLDQLYSAALRMTRNPADAEDLVQETFARAFASFHQFKEGTNLKAWLYRILTNTFINSYRKKQRQPQQSATEEIEDWQLARAESHTSSGLKSAEAEALEHLPDSDVKTALQELPEEFRIAVYLADVEGFPYKEIAEIMGTPIGTVMSRLHRGRRQLRSMLEDYARERGLTRTGDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VUD0</accession>
    <name>A0A1H5VUD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90919">
        <property type="protein sequence ID" value="SEF90919"/>
        <property type="gene ID" value="SAMN04489712_102466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF90919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="180" mass="18925" checksum="3BE6826AE1708CF5" modified="2017-01-18" version="1">MRRVLGAGVLALAGLTATGCSLLGSDDGPSAAQVPKAEIGTDSHVKGAIAKAVQPYAGKDVYVDILSLKRYDKVLRLVYAVTPRARGNSDKLPKQTFGGSWSGGDAGRPYLLDTKNLRVYEHLSIGSGDKASCACSVGIEEYPLDQPTVLYSDYPSPDESVKELTVVMPVVGPMPGVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VVG2</accession>
    <name>A0A1H5VVG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91210">
        <property type="protein sequence ID" value="SEF91210"/>
        <property type="gene ID" value="SAMN04489712_102477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF91210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="134" mass="13856" checksum="356379EBEE378FB3" modified="2017-01-18" version="1">MAHIDLSAPAALPPTAGYSHVASVAPGSRLVWTSGQVPIDADGTVAPAGDWAAQTRLAMRNIGIALEAGGATWDDVFKLTFFVVGTSALATIRAVRDEFVNTERPPTSSLVQVAGLFRPDVLIEIEAVAAVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W6D3</accession>
    <name>A0A1H5W6D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95045">
        <property type="protein sequence ID" value="SEF95045"/>
        <property type="gene ID" value="SAMN04489712_102607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009287960" evidence="1">
        <location>
            <begin position="25"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF95045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="354" mass="37836" checksum="EA4C40331C3AEE30" modified="2017-01-18" version="1">MKRTSLAVPAVAVLLVGGISGCSAEERRASTTPVAVASSPEPERLTPQSAAHEFQRFVSNDDVARASGDERLALHWVADGQMALTAAEYRRAVFHGEAVPRYDYKAPTLYVPKLSESTYPQWFVAVAERTAKPAPGARTDPDEARTAVMAFIRRSPESQWKLSLSTLLRDKAELPEIAVDSEGYAGAVLTGETDLLIPPKSVAGIQAAIAEEGPDSVPAKLMKPGPGTTGYFNETRQIKKRAGKAGLAFDVVFPATLHPVFPLRTADGGAFVLYALGRDTVTLAKDTEDRPPIPTDAAHLLDSLILGNELHVSQTLQFGAYDPPKAKPKKPQPKADVIAIDGAVVRAASPQKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WYE1</accession>
    <name>A0A1H5WYE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04110">
        <property type="protein sequence ID" value="SEG04110"/>
        <property type="gene ID" value="SAMN04489712_1032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="59"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG04110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="498" mass="52983" checksum="CDFFE6C03AF25735" modified="2017-01-18" version="1">MERPGTAAGRLLPVAGLAELPMRPDQPGRARELAVRQAMTRTLEVDLADPVITRVERLAAGPDPVAVADEWRALTYGELAAEARRLAALLERAGVGPGDVVGVGGRRCATVVAAFLAIELLGALYVPADAGWPAARVRDVLVQAGALALLDTGADERSPALLEGAAAAGCPVLRAAEAAGCEPWTGAPRLHSLDQPRYVLFTSGSTGRPKGAVVEHRGMLNHLWAKIVDLEMTAADVLAQTAPLGFDISVWQMLCPLLLGGRVEVIGDEVGHDPVALARVVDERAITIVELVPTMVRHLLDDLAGAPEGSLGGLRWMIATGEELPTELARRWLEAVPHARLLNAYGPTECSDDVTHHTITRADLDLLRLPIGTPIVNADLYVLRREDDGTWAACEMGEVGELFVGGICVGRGYLGDHDRTRDAFFRDPIGGVPGGRLYKTGDAVKLLPTGTLQYLGRVDRQVKISGVRMELGEIEAVLQRHPAVGAVAVVVHEFTPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X3G2</accession>
    <name>A0A1H5X3G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Betaine-aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06399">
        <property type="protein sequence ID" value="SEG06399"/>
        <property type="gene ID" value="SAMN04489712_10375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="13"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG06399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="477" mass="51003" checksum="E317AFF5B438D259" modified="2017-01-18" version="1">MREHDRLFIGGQWTAPAGTGVIEVISPHTEEVIGRVPEGTEADIDHAVAAARRAFDTGPWPRMTPAERAEVVGRLAAIYAERQQEMADLVTAEMGSPIMFSVFGQSAIPQMVLQYYTDLAASYTWEEERPGMLGPVTVTREPVGVVAAIVPWNVPQFTLMLKLAPALIAGCTVVAKPSPETPLDTYLLAEWITEAGIPEGVVNIVPAGREVGAYLVAHPDVDKVSFTGSTAAGRQIAAVCGEQLKRVTLELGGKSAAIVLEDADLAATVEGFKLASLMNNGEACAAQTRILAPRSRYDEVADALAAMVGSLTVGDPADYSTEIGPLVARRQQERVEGYIRLGQEEGAKLLTGGLNRPHDRGWYVAPTVFADVDNSMRIAQEEIFGPVLALIPYEDEADAIRIANDSAYGLGGSVWTADVEHGVEVARQIRTGSCGVNMYVLDPNTPFGGYKNSGLGRELGPEGLVAYLEHKSIPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XN62</accession>
    <name>A0A1H5XN62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13211">
        <property type="protein sequence ID" value="SEG13211"/>
        <property type="gene ID" value="SAMN04489712_103331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045713">
        <property type="entry name" value="DUF6069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19545">
        <property type="entry name" value="DUF6069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG13211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="211" mass="21751" checksum="C6C963180C81FD51" modified="2017-01-18" version="1">MAKVPFGPHPDDASGPRAHPRGRTRQPLHRAYRCPATARSPQVREASVERYRGFAALHGVLAAGPQIRVGRLWAGGLIAALCAVLVTVAGALVARGVLHVPVPVPVSPRVDGLAVSAAYALCMGALTLQATGLLHVLMLVSPRPVSMLAWVCGPVTGIATLAPLVVRAGLEARIATAAINLATGLVVIGLLAATASLSARWPGPPDLDPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XSX0</accession>
    <name>A0A1H5XSX0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_103392</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14768">
        <property type="protein sequence ID" value="SEG14768"/>
        <property type="gene ID" value="SAMN04489712_103392"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="8"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG14768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="422" mass="44000" checksum="7B64CB91C371C938" modified="2017-01-18" version="1">MSRNQTTVVVTGLGATTPLGGDVPSTWSALLAGRSGVRPLDWEGVEELPVRFAAQLAVEPTEVMPKHRLRRLDRNEAIALIAAHEAWQHAGYAFGDRAGGTVDGDRLGVVISSGIGGLHTALNSYDVYREKGWQRVSPFTVPMLMPNGASGLVGIEFGAMAGSHALVSACASSAEAIGYAVDMIRSGRADVVIAGGTEACIHPLQMASFGSMRALSTRNEEPARASRPYDKNRDGFVLGEGAAVLILESEEHARARGAEIHGIASGCGYSGDAYDIVQPDPSGTGQSKAMRRALADAGLTAEDIVHVNAHGTSTPLGDVAELASIKAALGEEAAAKLCVTATKSMTGHLLGGAGALESLITVLTLRERLVPPTINVDDLDDAVDLDIVRGEPRELPDEPIAALNNSFGFGGHNVSVAFQRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XUL2</accession>
    <name>A0A1H5XUL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15348">
        <property type="protein sequence ID" value="SEG15348"/>
        <property type="gene ID" value="SAMN04489712_103414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG15348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="28701" checksum="54BC6625DE94B4DC" modified="2017-01-18" version="1">MRDLNAVIGSHDLLLVTLDTLRYDVAAELAEAGRTPNLTAVLPGGRWERRHAPGSFTYASHAAIFAGFLPTPDGPGPHPRPFAATFPGSASTGQGTWVFDAADLPTGLARAGYHTVCVGGVGFFNKLTPLGSALPGLFAESHWEPEFGVTDPASLEHQIGRVAQIMARQPPGRRLFLFLNVSALHQPNWFHLDGATREHGDSRASHAAALEYVDRHIGRLLGLMRRPCLVIICSDHGTAYGEDGHTGHRIGHEVVWTVPYGEFVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YLQ1</accession>
    <name>A0A1H5YLQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S1 RNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24515">
        <property type="protein sequence ID" value="SEG24515"/>
        <property type="gene ID" value="SAMN04489712_10461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="104"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG24515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="18442" checksum="B9120549D1378CF9" modified="2017-01-18" version="1">MAEDQKAETRPAFLQTLEPGQVRRGTVTSLERFGAFVDLGGASGLVSVPELSWRRFDDVSQVVRVGQDVTVMVLDVDLDRERVSLSLKALQEDPWKQLARTRLGDVVSGPVTKVVPFGVFVAVADGIEGLVHASEFLPGEPPAEGRELTVRIRDINLWRHRMRLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YSK2</accession>
    <name>A0A1H5YSK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26477">
        <property type="protein sequence ID" value="SEG26477"/>
        <property type="gene ID" value="SAMN04489712_104136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="50"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="17967" checksum="8AA51F0BE0109FF5" modified="2017-01-18" version="1">MDVRRHHSLCASLRSGDGNDADSASPSSTRLIDSRFEKWDVPISDQAPGQVRRWAADLLTRWGAADAVEDAVTVLTELVTNACQAGASRVIVSIEPDAGPNVIEVCVWDDAPGVPQKHEPDLSAERGRGLFMVDALAARWGHHALPLGPGCSGKVVWADLAAHGAGSGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YSS2</accession>
    <name>A0A1H5YSS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26356">
        <property type="protein sequence ID" value="SEG26356"/>
        <property type="gene ID" value="SAMN04489712_104131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290883" evidence="2">
        <location>
            <begin position="38"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG26356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="29182" checksum="48CEC6BF70E641A1" modified="2017-01-18" version="1">MAHQQVSCIGRGLLNRLIIASASSFACGVVLSQPAAAAPPSQRPKPPSVNGRTYVFGAHQDGRPGGAPGGQGPRAQRALSGSAPKKSLPTLCSWWRGGVAVCKPISVPDDKPEGKPKVSPAELAITEWRRLPVPAPVVRTAPPRGRDGLVGLPHWFWVANWRPLTGRAEAGGVWIEVTARPQNLTIEPGGGQRPVRCSGSGTAYDPSRPAVSQRTDCSYTFTRSSFRRPGGAYRVRATVVWGGTWTGSGGTGGVLPPLSRSVSFPVRVVEAQSLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YYB4</accession>
    <name>A0A1H5YYB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29051">
        <property type="protein sequence ID" value="SEG29051"/>
        <property type="gene ID" value="SAMN04489712_104250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="4">
        <location>
            <begin position="121"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG29051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="358" mass="38363" checksum="AD4ED892C38A3C55" modified="2017-01-18" version="1">MEPRKPEPSAAYRPGGAVATDTVALKAALGSPTDRRPSMQSAVISRALRFGLRPIVHRLPGHPMGIRTARTAVEAASLLVGQHPRTRIEGVHAPLEGPGGTRHLAGEMLVPEKGRVTDAAVLYLHGGGYIICSPRSHRPITSRLAVETGLPVFVPHYRLAPEHPFPAPLEDALDAYRWLMNEGYPASRIVIAGDSAGGHLAASLTGEICRTKLPTPAGLVLYSPWVDLTCELSTECDQRTRDAYISAHTARRIGQLVMGQAELADPRLALLECSWTGVPPVLIQVGGAEMLRPEAERLAEALTEAGADCRLQVWQGQIHVFQLLNRVLPEARAAMRESARFITSVIDGFPAAGSGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZW2</accession>
    <name>A0A1H5YZW2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ORF">SAMN04489712_104269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29472">
        <property type="protein sequence ID" value="SEG29472"/>
        <property type="gene ID" value="SAMN04489712_104269"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG29472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="431" mass="44744" checksum="D07A74CED03DAA0E" modified="2017-01-18" version="1">MTGIDLSQQLFDRAGEVVPGGVNSPVRAFRAVGGTPRFIASARGPYLTDVDGNEYVDLICSWGPMILGHAHPAVVEAVQRAAERGTSYGAPTPGEVELAEEIVARTPVDKVRLVNSGTEATMSAIRLARGFTGRGKVVKFAGCYHGHVDALLAAAGSGVATLALPDTPGVTGATTADTIVLPYNDVPAVELAFGEHGHEIACVITEACPCNMGVVPPEPNFNRLLKSLCERYGALLILDEVLTGFRASRSGWYGLEGVPGDLMTFGKVMGGGLPAAAFGGRADVMDHLAPAGPVYQAGTLSGNPLATAAGLATLRNATEEVYEGIARAASVVARAATEALTKEGVPHRLQVAGSLFSIFFTDEPVLDFAAAQRQNAKAYAAFFHAALDQGVYLPPSAYEVWFLSAAHDDAALDRVVSAMPGAARAAAEVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z688</accession>
    <name>A0A1H5Z688_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LppX/LprAFG lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31871">
        <property type="protein sequence ID" value="SEG31871"/>
        <property type="gene ID" value="SAMN04489712_104382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009830">
        <property type="entry name" value="LppX/LprAFG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07161">
        <property type="entry name" value="LppX_LprAFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291299" evidence="2">
        <location>
            <begin position="23"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG31871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="30446" checksum="641275DB2D6F71C4" modified="2017-01-18" version="1">MGRRMALRATAAAAVGTTMVISLTGCLGGSGDGSGSSGTIRLSANTALVKASERTGQADTFEADLTITDAGEGATIRGSGNVRLRPSLAFSATLKEARMGGQTLPGAGGQAILVDGALYAKVPQLAQLAGIDKPWLRLNVDQVGQRAGFSFDQITNAVQRINPAEQTKMLTGSKDARRVGEEEVEGVKTVHYAGTVTFEDALNRLDPQAREKVRQWHTDGSDRLSFDVWVDSENLPRKLVVKGTADGRDTSTVTVLYRDFGEPVTVNAPPSDQVGDVTDQLGRFLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZBV0</accession>
    <name>A0A1H5ZBV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33510">
        <property type="protein sequence ID" value="SEG33510"/>
        <property type="gene ID" value="SAMN04489712_104458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="587" mass="61933" checksum="EE39BAA459267D88" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZFC6</accession>
    <name>A0A1H5ZFC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34327">
        <property type="protein sequence ID" value="SEG34327"/>
        <property type="gene ID" value="SAMN04489712_104494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG34327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="317" mass="34666" checksum="1C053052F5955AE7" modified="2017-01-18" version="1">MATFSLDDMRAVCKGRDAWWTVFLVDPVAIRLALPIANRTSITPNQLTAVAFAFGLAAAGCFALAAPGWLALGALLYHVGFVVDCMDGKIARLKGTGTTFGAWLDFMLDRVRDSLCAVALTGGQYARTGQVAYLYAGMAVLALDMFRYVNGPQIVKARRAMRTATAAARRRAAAVAEGDPRMAVLGGQGHRVVTLGGGEGRVEEPEAEFGRTPHPDPHYVFDTRWPWYRRIRQGLLRRRVRTHLVSGIEFQMSVFILGPLTGAIIPIIVVTGALLVFFELVIIYKFWLSTRAHTRLLAVLEAGSRPVTDPARSPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZWF0</accession>
    <name>A0A1H5ZWF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40779">
        <property type="protein sequence ID" value="SEG40779"/>
        <property type="gene ID" value="SAMN04489712_10550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG40779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="195" mass="21572" checksum="BBC38FBE52960F59" modified="2017-01-18" version="1">MSGTDRLRLAIIIGSTRDGRFGPTVAGWLASRARRRADLEVDLIDLAEARLPQTLPDHDGDLPEPVRALAPRLAAADAFAVVTPEYNHGYPAPLKTAIDWYYDEWKAKPVALITYGRESGGRNAAAQLRQVFGELHAVTIRDGISLPCYWEQFAADGSWPKAGADCNTAVKTTLDQLTWWALALREARVRRPYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A0R4</accession>
    <name>A0A1H6A0R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sec-independent protein translocase protein TatB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_105112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42010">
        <property type="protein sequence ID" value="SEG42010"/>
        <property type="gene ID" value="SAMN04489712_105112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG42010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="12765" checksum="8BD1AFC50642EA4A" modified="2017-01-18" version="1">MFDVGLGEMLVLVVLALVIFGDRLPSVAGQAGRMLRQLRGMADSAKRDLQEGLGPEFKDFDIADLHPKTFVRKHLLEDNDDDRPASRFDGLEPAYSSTGPDDLGYGERPPFDSEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A271</accession>
    <name>A0A1H6A271_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_105164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42863">
        <property type="protein sequence ID" value="SEG42863"/>
        <property type="gene ID" value="SAMN04489712_105164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG42863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="562" mass="59151" checksum="58018B0C9108FBE3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A438</accession>
    <name>A0A1H6A438_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_105179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43120">
        <property type="protein sequence ID" value="SEG43120"/>
        <property type="gene ID" value="SAMN04489712_105179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG43120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="27048" checksum="E12AE95A5269AEE5" modified="2017-01-18" version="1">MKLTLRVWRQKGPQDKGGMVEYQLDDVSPDMSFLEMLDVLNERLILDGEDPIAFDHDCREGICGMCSLVINGTPHGPEKATTTCQLHMRKFSDGEVIDIEPWRSQAFPVIKDLVVDRSAFDKIIEAGGYISAPTGSAPDAHAVPVPKPDADRAFEAAECIACGACVAACPNGSAMLFTAAKVTHLGLLPQGQPERYDRVVNMVEAHDEAGFGGCTVTGECTVACPKGIPLDTIAQLNRDYLAATAGRRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9V5</accession>
    <name>A0A1H6A9V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator / MocR family aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45529">
        <property type="protein sequence ID" value="SEG45529"/>
        <property type="gene ID" value="SAMN04489712_105308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG45529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="467" mass="49473" checksum="0DB33ACA630A68E6" modified="2017-01-18" version="1">MTDLHLPLDPAAGRLSAQLAAGLRAAVRDGRLAGGTRLPSSRDLARDLGVSRGVVVTAYEQLVAEGFLVSRRGDGTRVAPLARPDLPPLRSAPVWPDEEPAARAGTSPCDLRPGPDLSAFPRELWAAAIRTALRTIPSDALSYPEPSGAAELRGELAGYLGRVRAAHAVPERIVVMNGVAHVISSVVRLLAAAGHTVLAVEDPSGHRQPPMLEAAGVGLVRIPVDAHGIDVAALAASPARAVLVTPAHQYPTGVVLAPGRRAELIQWARAVNGLVIEDDYDAEFRYDRSPVGCLQGLAPERVVLAGSVSKSLAPALRLGWAVVPASLAERLRMHRMNTDIGGPVLEQHALAHLLASGAYDRHLRAMRRRYRARRDALAGALAARLPDVRVQGVAAGLHLYVELPAGCDEEKVVAEAAHHGLLLQGAAPMWSRPAKPALVIGYARVNETRLRSAVDILDRVIARGIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AF25</accession>
    <name>A0A1H6AF25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46774">
        <property type="protein sequence ID" value="SEG46774"/>
        <property type="gene ID" value="SAMN04489712_105382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292607" evidence="1">
        <location>
            <begin position="32"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="643"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG46774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="936" mass="98133" checksum="5E7FAE34F43968C2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AGM5</accession>
    <name>A0A1H6AGM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_105418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47390">
        <property type="protein sequence ID" value="SEG47390"/>
        <property type="gene ID" value="SAMN04489712_105418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292700" description="G5 domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="5">
        <location>
            <begin position="96"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG47390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="28004" checksum="C5177A81E6AD06F4" modified="2017-01-18" version="1">MRRTPALALTAVLLAASTSACGGDDGGGSRPAAADAPKVTTPPARQVTITVDGRTTTAMTTGTTVREVLTQAGVQLGRYYLVKPKIDEPAGNAVKVRLLLSKPVTRTLKIQAPVKRKTNSKLGPWSQRTARKGRDGLKVVMTAYVRDKKGKKVKAVVAEKITRKPVTQILEVGPQPASVGGTAAGLNWAGLAKCESGGRPNAVNPAGYYGLYQFSLQTWGSVGGTGLPSNASPAEQTYRAQLLYNKVQGRWQGQWPNCGRFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJR5</accession>
    <name>A0A1H6AJR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trans-aconitate methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49003">
        <property type="protein sequence ID" value="SEG49003"/>
        <property type="gene ID" value="SAMN04489712_105509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="37"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG49003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="27254" checksum="404B6592044DA2FA" modified="2017-01-18" version="1">MDVFGSVADLYETARPGYPPEIAEEIVAYHGGTPASVVEIGAGTGKGTEVLARIGAPLTCLEPDPRMAALLATRFPDVRIRASTFERWSPPAGGVGVLACAMAWHWLDPATRNTHARQALAPGGTLALFGHRYDYADPGQRAAIRSALHAIDPTVRERPADWFHQDVVDHGRFVNVRKEVFRRDLPLDRERYLDLVRTFGPYLSRSPEQQQRGLTALGRLVDDFGGTVVLDLRTTLVLGQGGRRIHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B198</accession>
    <name>A0A1H6B198_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54653">
        <property type="protein sequence ID" value="SEG54653"/>
        <property type="gene ID" value="SAMN04489712_106170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
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            <end position="361"/>
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    </feature>
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            <end position="600"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG54653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="605" mass="59890" checksum="D00D5D4C7FE4C0A6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3H6</accession>
    <name>A0A1H6B3H6_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Thermomonospora echinospora</name>
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        <lineage>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="SEG55391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="35109" checksum="FEBEB1AE90FEEC30" modified="2017-01-18" version="1">MESAQDLLGALARRYAFGDLGALAGRALPPEAAARVAALCAFGQRVLELDAEDFGMPEAAGEVPVDLLDRARASRMPQSPRERPRGALATLHPGYALLLEVIGIHWRRREMAALVGVIHIVSEYLPVLAWEPVLGHAADPALLPAAVTGPDSRFGTALDPDAPRRCGHTQAERSACARSLRVAREPAAGWRAYLDRQHSQVAQALGVCAAECRTPCSVITRLEDKERAALVARCTLAHTFTESALVRLRHSAPVGHGFGVPSCEEVEEAWARACASLRRQPLGEAALADAGQDSYPLPGLPALVSAIAGAPIAPGTLLRDVTHRLVSVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B609</accession>
    <name>A0A1H6B609_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56273">
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        <property type="gene ID" value="SAMN04489712_106300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="30729" checksum="E7660B646A60595F" modified="2017-01-18" version="1">MLRVARAALFAMVPAELVLAVLLVSGVPLPHPVVVAVEVGVLAVLVLEAAAGYRLFRAERRAGADRRAALRGAWERLVPEQVRRIVGFDSKGMVSLALWVARRRHGVPPGAVAVSYSRAQTSTMLMFLFAMVVELVGVEIVLRALGVPAGLRAVVFVIDAYTILAVLAVVAACITRPHVVSTDGVRIRYGAFFDLHVPRELIAEVRHVRSYDESGMVKVDGDRLTVAVASQTNLVIELTEPVTAVRPFGRRAQVRTIRFFADDAAPAVNALRPRHEPAPGTVGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B729</accession>
    <name>A0A1H6B729_9ACTN</name>
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        <name evidence="12" type="ORF">SAMN04489712_106327</name>
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        <name type="scientific">Thermomonospora echinospora</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
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    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56649">
        <property type="protein sequence ID" value="SEG56649"/>
        <property type="gene ID" value="SAMN04489712_106327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="405"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="673"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="25"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1033"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG56649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1073" mass="110547" checksum="D29EBA88AB6C136A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKB6</accession>
    <name>A0A1H6BKB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MT0933-like antitoxin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61114">
        <property type="protein sequence ID" value="SEG61114"/>
        <property type="gene ID" value="SAMN04489712_107185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG61114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="94" mass="10256" checksum="27858FAFF8C70601" modified="2017-01-18" version="1">MGRVFGRRTGVPGTDDHDLGGDHMSIVSKVKQMLGQHPDRAREGVRKAGDEFDERTGGKYSDQVAQGRQRAEEYIEREGGQPRPGGQPPQSPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLU9</accession>
    <name>A0A1H6BLU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter membrane protein 1, PAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_107190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61166">
        <property type="protein sequence ID" value="SEG61166"/>
        <property type="gene ID" value="SAMN04489712_107190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG61166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="228" mass="24501" checksum="0DEAB412C1085068" modified="2017-01-18" version="1">MDQLLDFSPVFENLDQILAGFWATIRIAVVTAVLALLFGTFLTALRVSPIPVLKRTGGFVVNLLRNTPLTLVLAICILAVNDTLKVTLSSVEGVNRYWWGVLGLSVYTSAFVSEALRSGINTVPIGQAEAARSIGLTFTQSLRMIILPQAFRAVIAPLGSVLIAMIKNTTVVGAVAYGSEAAAVMKLMFFDLGASIPIFIGFAIGYLILTLPTGFFFGWLAKRMAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BVV0</accession>
    <name>A0A1H6BVV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_10856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64810">
        <property type="protein sequence ID" value="SEG64810"/>
        <property type="gene ID" value="SAMN04489712_10856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG64810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="37117" checksum="21429FDBFBCD5D84" modified="2017-01-18" version="1">MLGPVTPGGTRYEESGSVTIRVGINGFGRIGRNFYRALLAGGADVEVVAVNDLTDNATLAHLLKYDSILGRLGEDVKAGADEIAVGGRSIKVFAERDPGNLKWGDLGVDIVIESTGLFTDATKAKVHADNGAKKVIISAPAKNEDVTLVMGVNDDSYDPANHTIISNASCTTNCLAPMAKVLHDTFGIERGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVLPELKGKLDGYALRVPIPTGSATDLTVTLGRETTVEEVNAALREAAEGPLRGVLTYTEDPIVSSDIVTDPASCILDAGLTKVIGDQAKVVGWYDNEWGYSNRLVDLVQLVGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2E8</accession>
    <name>A0A1H6C2E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67128">
        <property type="protein sequence ID" value="SEG67128"/>
        <property type="gene ID" value="SAMN04489712_108256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG67128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="34791" checksum="D1C51D3AA44EF58C" modified="2017-01-18" version="1">MEFKARAFWLRSPGQGEIRPVEVAPPADGEVLVRTLYSGISRGTETLVFRGGVPKSQYRAMRAPFQEGEFPGPVKYGYLNVGIVEQGPPALLGRTVFCLYPHQTRYVVPTDAVTPVPDEVPPGRAVLAGTVETAVNALWDAAPMVGDRVAVVGAGMVGCCVARLLAAIPGTRVELVDVDPARADTARALGVGFAVPERAAGECDLVVHASATEEGLTRSLELLADEGTVLELSWYGDRRVGVPLGEAFHSRRLVVRGSQVGAVSQARRARRTFADRLSLALRLLADPAFDALITGEHAFAELPRVLPRLAAGELSSLCLRIAYESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8F6</accession>
    <name>A0A1H6C8F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-dependent flavin oxidoreductase YrpB, nitropropane dioxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69047">
        <property type="protein sequence ID" value="SEG69047"/>
        <property type="gene ID" value="SAMN04489712_10944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="7"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="37547" checksum="D2BA05F9966DA67A" modified="2017-01-18" version="1">MHPALRTRVCELFGVRYPIVQTGMGWVSGVHLTAATAAAGGLGILAAVTMSDEQMLTAVREMRERTDAPFGVNLRPDQPDIAERVKALAHEGVRVVSFAGAPTKDTVSALHDAGVLCVCTVGMRRHAEKVAALGVDAVIAQGGEGGGHTGSVPTSLLLPQVVDAVGADIPVLAAGGFHDGRGLVSALAYGADGVAMGTRFLLTADSRVPEHVKQDYLKAGVTQTLVTTAVDGMPQRVISTPFITALEGESSWRRGVRILRASTRLRELTGQSPLKAVREGLAMRREQDMTLFQVASSINVPLLIRAALVEGRPEAGVLPTGQVTGVLDDLPTVADLIDRIITEAETTLHRLEGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CC53</accession>
    <name>A0A1H6CC53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70462">
        <property type="protein sequence ID" value="SEG70462"/>
        <property type="gene ID" value="SAMN04489712_109172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="15275" checksum="F05F5E7BC8D65A02" modified="2017-01-18" version="1">MSDRAPGAGVMIGMCRLPLNATAPKIAREVVARLARSWGIAEIEDAVKIAVSELVTNAFVHAAGMPGSTVLVEVRRVEACFHVQVRDGSSAAPVDRGRGHDDENGRGLLLVRELTDACGWTPTPFGKTVWFELKAAWPLDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDE3</accession>
    <name>A0A1H6CDE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70797">
        <property type="protein sequence ID" value="SEG70797"/>
        <property type="gene ID" value="SAMN04489712_109206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="197" mass="21124" checksum="7AE7AE979BAE0B65" modified="2017-01-18" version="1">MKPVAVTDGAVLSVVVVRVAGMSSFSGWAVVDLDEGRDPGEFVGVLCDACSDPLRVYVDGRRVFVLADFAPQFSAVVDGLVPHWARRAITAADYDEYGVENTVLGPEAQAVHVASISEEIEGLPDADTPQTRRAAAELFGVRPEALDEVSATWAEEGPMPSCIGEPYLRWWAALGAAWPEDFGTRSFDPREKSAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDK4</accession>
    <name>A0A1H6CDK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71034">
        <property type="protein sequence ID" value="SEG71034"/>
        <property type="gene ID" value="SAMN04489712_109233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="27906" checksum="8F9264350BC757A0" modified="2017-01-18" version="1">MSEDLLPIGRFARLCRLSVKQLRHYDDLGLLTPAWVDPGSGYRYYRRSQARTAMSIGLLRSLDVPLVAIGRVLSGDDPAGALGEVRDRMEADLARRRRTLAALDRVLADGLPRVEVTVLHEPARRVRVVRDTATPSTIAEVTGRCVARLLDELGGAPPTGLLLGLFPQDLAEEFTVGVAAEAGDAQATDVLPGGVFAVATHVGPYDQIDLTGHGLLAWCGERGHLPVGPIREVYLTNPADTPPERLVTQLMIRLEDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CHS9</accession>
    <name>A0A1H6CHS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyl transferase AbiEii toxin, Type IV TA system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72462">
        <property type="protein sequence ID" value="SEG72462"/>
        <property type="gene ID" value="SAMN04489712_1102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG72462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="22759" checksum="FC5F8F6CC3D4537D" modified="2017-01-18" version="1">MDTLHELATRIGLTATEKYGFALAGGYAIQAHGFLDRISEDVDLFTVNEARDQFGEAVAAATAAYRSAGFDVEVPLSNDGFARLLITTPDGHSVKVELGIDWRAHPPVGLSVGPVLHPDDAVGNKVAALYGRAEVRDFVDVDAVLRSGRYSTGDLLRLAATADPGFEPEMFVHALNALDRLPDQAFGVHGLSPSQIAELRNRFKTWAAEITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIG4</accession>
    <name>A0A1H6CIG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein, DUF1330 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72587">
        <property type="protein sequence ID" value="SEG72587"/>
        <property type="gene ID" value="SAMN04489712_11016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010753">
        <property type="entry name" value="DUF1330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07045">
        <property type="entry name" value="DUF1330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1330" evidence="1">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG72587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="103" mass="11597" checksum="0D955DD5C15B50DC" modified="2017-01-18" version="1">MAFGMVGAMTVYALAQISIHDRRRYDAYVAGFMDVLTTYQGRLLAADERPEVVEGEWPHDKVILLSFRDRDAFETWANSPEYQEISKDRLAATTGVVILAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIN6</accession>
    <name>A0A1H6CIN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72603">
        <property type="protein sequence ID" value="SEG72603"/>
        <property type="gene ID" value="SAMN04489712_11018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294890" evidence="1">
        <location>
            <begin position="28"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG72603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="257" mass="27189" checksum="5841CAADA0E03A48" modified="2017-01-18" version="1">MGVRKPAVLVMLLLGGLLTAGCDDDGAAAGEPGAASTSAQPTAAVNGVERLTAQEILDRAGQASLAAGSVRMRGGFGKGGLQFRMDVRSSAPDRAMGEVTFGDNSLHLVRIGRTVYMKADDAFWRELGGRAVVDMMSGKYLKATIDDTNLRKLKAFTDHRELLGDALRSTGALTKGTTAMVGWNSVITLKGGDIGNIYVSTVGQPYVLQLEGTEKERLDFSDYGVPVSITPPPPNTVIDADVFKKLGGDIDRFPVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRS4</accession>
    <name>A0A1H6CRS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75353">
        <property type="protein sequence ID" value="SEG75353"/>
        <property type="gene ID" value="SAMN04489712_11124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12316" checksum="62F9823E7DE332CE" modified="2017-01-18" version="1">MAGDRGMGSHDGPNARIGEPKTGPGERGHGGAPGRAHLAVASSASDRPGAKMKTPGDYRLDRFFNALVHKWTAGGAFRHRRVFARTSVGRGRQVRNRQRVAVAFASLNLGPASVTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSQ8</accession>
    <name>A0A1H6CSQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sortase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75693">
        <property type="protein sequence ID" value="SEG75693"/>
        <property type="gene ID" value="SAMN04489712_11172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="21630" checksum="89B1CB3A5287E5C7" modified="2017-01-18" version="1">MTYELWGTGRYTKEQQSRLNDALLKSWNAPAHQVTTERVKLGDGLALIRIPRLGKEYRYVVVEGVKPADLRKGPGHYPGSALPGQIGNFVVSGHRTTYSAPFNQIDRLRDGDRILIDTRRTQYVYKVTGRRVVKPNAVEVTAPVPFHPGRRPTEPLITLTTCHPKYSAAKRLIIFGELAEERPRRLTTASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUN5</accession>
    <name>A0A1H6CUN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76672">
        <property type="protein sequence ID" value="SEG76672"/>
        <property type="gene ID" value="SAMN04489712_111192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="749" mass="85286" checksum="D8FF42C0CDE1E1B0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUZ3</accession>
    <name>A0A1H6CUZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein, gntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76792">
        <property type="protein sequence ID" value="SEG76792"/>
        <property type="gene ID" value="SAMN04489712_111207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="15265" checksum="6AA98B33F0965710" modified="2017-01-18" version="1">MSVDPTADRPVYQQVADILRDRIRTGELAPGQLLPSEPHMVDEFGVARSTARQALAVLRGEGLVVTVPRRGTVVRPRADAEIVTLVPGQEAEARMPSPDERRRLKIPEGVPVFVVKRPGQEPEVYPADRTRLRAADEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVQ5</accession>
    <name>A0A1H6CVQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77072">
        <property type="protein sequence ID" value="SEG77072"/>
        <property type="gene ID" value="SAMN04489712_111244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="27803" checksum="08338BA83A4F9ED2" modified="2017-01-18" version="1">MDLQLSGRVAVVTGASKGIGLAVVRTLLAEGARVVAASRKTTPELDALAGPSLLHVPVDLMDHDAPGQVVERAVREFGGLDVLVNNAGGPPPGVRLPRSSFLEADDGQWLAMFEFNLFAVVRAVRAALPHLIERGGGAIVNVSSGNARQPSPMNVDYGAAKAALNNLGQALSEEFAARGVRVNTVSPGPVRTAWWTDEGGVADMFAAQAGTDRDTVMDSVVPETMGLTIGRMIDPQEVADAVVLLASPRSAGTTGAEFVVDGGFLKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CY72</accession>
    <name>A0A1H6CY72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, DHA2 family, multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78129">
        <property type="protein sequence ID" value="SEG78129"/>
        <property type="gene ID" value="SAMN04489712_11233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG78129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="523" mass="54228" checksum="C43078BF47849A5A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZG4</accession>
    <name>A0A1H6CZG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EF-hand domain pair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78412">
        <property type="protein sequence ID" value="SEG78412"/>
        <property type="gene ID" value="SAMN04489712_11274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="79" mass="8386" checksum="4E0EF271C4F806C6" modified="2017-01-18" version="1">MSDQYEAVFARYDTDGDGQLTVDEVTAAIAGMFPETEVDDLSGIVAALFAEYDADHDGLLSVAEFVPLAENLPELGSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0J2</accession>
    <name>A0A1H6D0J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, DUF2236 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78325">
        <property type="protein sequence ID" value="SEG78325"/>
        <property type="gene ID" value="SAMN04489712_11263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="33"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG78325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="298" mass="33758" checksum="30270A94A7B57E29" modified="2017-01-18" version="1">MHWRGGAVAAPPERPHEVTSTAVTPLGPDSLTWRFFGDTRLLLVGPRAAVLQNMLPALGQGVLDHSVFFSETFARLRRSAGPILNTVYGGDEAAATGRRVRDYHTEIKGTMPDGSRYHALDPETYYWAHATFVDHMLYGVETFIRPLSEGERRRIYEESRTWFRLYGVSDRAMPEDWKGFQAYWKHMLEEVIVPHKTARYGVGYATKGLPAPPKVPARLWRAVSPPLNGIASFLTIGGMPPAAREPLGLPWSADDERRYQRFAAAVRRAGRLWPLLPEAVRYFPQARRAFARTRRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4X8</accession>
    <name>A0A1H6D4X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclease-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80360">
        <property type="protein sequence ID" value="SEG80360"/>
        <property type="gene ID" value="SAMN04489712_11368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="NERD" evidence="2">
        <location>
            <begin position="85"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="28193" checksum="66AB8E2C0B5A8D76" modified="2017-01-18" version="1">MIGSSIYTRGREAFTGGSPQAVFEELWLQDRKSRLRTRAIIAVVALLVGGYVVSPLFGLVLAVVAGGLDALVHYRRYQAAGVWRRGLRGEERMSRLLRWTLERRGYRVLHQRVVPGHDTLDQLLIGPGGVWLIDNQAWHPETELTRHGDRLFIDDRTPSQLVKRLTGMARTVSGLLTKRLGTEITVAPLLAVHGGRIRGRGGFTADGITVLSPWALLRWPARHPTAELSPEQIEDVLRAAVYTLPIGGRTMTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7I1</accession>
    <name>A0A1H6D7I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81367">
        <property type="protein sequence ID" value="SEG81367"/>
        <property type="gene ID" value="SAMN04489712_11438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="36"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG81367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="506" mass="52863" checksum="BC337238A56DFD95" modified="2017-01-18" version="1">MTAPLRHRWAGLVAQAGGQARQRLLAVVGGPARFQVITILSCVLALDAADKGTIGAVGPELKSNLGIDNTQLGSLTAVSSGVGAVAAVPVGVLTDRVNRTRLLAVSIIAWGAAMAAGGLAGSFTWLLLSRLALGAVTATAGPTLASLIGDYFPPGERGRIYGFILSGEMLGAGFGLLVGGNLSQLLSWRAAFGFLALLGLCLVYVIRRWLPEPARGGQSHLRPGQTDLKPRPDEWARGRPEGEGDDAGDDVAAQREDPARSAVEEHGVRPRPDLVLRRDPARMSMWAAMRYVLRIPTNVILIVASALGYFFFAGLRTFGVVFVSRHYGLGYGAISGLVVLIGVGALVGVLTGGRVADGLIRRGHPSARVLVPAVTYLLAAGLFVPGLATTSVAVAVPLFALAAASLTAANPPLDAARLDIVHSRLWGRAESIRTFLRMGAEALAPVTFGFVADLFGPGGKGGARGLEYAFLIMLVPLVANSVILLRGLRTYPRDVATAAESERVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DA32</accession>
    <name>A0A1H6DA32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81386">
        <property type="protein sequence ID" value="SEG81386"/>
        <property type="gene ID" value="SAMN04489712_11444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="DUF5519"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="DUF5519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="17171" checksum="1938F9D8B2601787" modified="2017-01-18" version="1">MSRGRRPRSVSYADLAVDRFRNWPLRACRADCPPGRALALPGLQIVHFHQGDLAEVLLTREVIGRLTAALTASGRVDVPRNTGWVQVHLDTDGDLFLLQSLVSLAIQANDPTCRPHRHTMAACPHASPGLRHRRATAEPDLLVHGPARHDHAAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DA44</accession>
    <name>A0A1H6DA44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81693">
        <property type="protein sequence ID" value="SEG81693"/>
        <property type="gene ID" value="SAMN04489712_114120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="174" mass="19333" checksum="13BDEE78D9EBA888" modified="2017-01-18" version="1">MLDYTGAVPAGNVLIVHKMINAYLMPDGVSDAETSDNDELQTYRADPWPNNASVYWEFEPARGRPGAYYIRSQPNRRYLGVRGNLARADAVVTLRMNQSNAGLWEPVPIPGLPDIPGHPVVRALRLRGTNFAMATAGNLLNRDAEIHLDRAWDGEFTFYHAFLLIPGESVVTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAY4</accession>
    <name>A0A1H6DAY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82379">
        <property type="protein sequence ID" value="SEG82379"/>
        <property type="gene ID" value="SAMN04489712_11517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="384" mass="40882" checksum="FA4B1410E4723437" modified="2017-01-18" version="1">MITEDSIRETLEHGASQAPDPDRVLAGLPARIRTARRRRMATASAGTVAALVTLSAVVNATGLSPLDQDRNVATGGPGAGNAYGPTWLPSGMYEVVRTVSFTSGPQRYERIWSFGPMTKVGRLRPLISLTVAEDGESPLDPLPSPDGRNAAPRTPRHIPGIDKVEPSGGPDVHASDGTSPPPGTDTGTGTEQVTINGHPAVRERSSNICAIAWRPTPTQLLTVVSQDMGNDCTVASRFAQSVAKGSSAPVNDAIKVNRMPEGYRVWSTGALRTNSSGCVARLSIRPADPTADPQLPLPADQIEYGHGPLPEGGEPLTVGGRPARYYERLELDETLFQVVAIDLGDGRRLLVNKYAREPVPRTVLVEFAGQISVGEPPNCNWLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBC2</accession>
    <name>A0A1H6DBC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_11577</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82747">
        <property type="protein sequence ID" value="SEG82747"/>
        <property type="gene ID" value="SAMN04489712_11577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="297"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG82747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="371" mass="41984" checksum="43987EB2DC933E0A" modified="2017-01-18" version="1">MRGMAQLVKRAYKYRFHPTPEQTQELARTFGCVRLVYNKALEERIRAYTQQGRRVSYGESSAWLTAWKRTPEYGFLAEVSSVPLQQALRHLQAAFTNFFAKRAKYPVFKSRKRSRASAEYTRSGFRWRDGELTLAKMDAPLDIVWSRPLPAAAEPSTVTVSRDAAGRWFVSLLVGEKIRPLDPVEQSVGVDAGITALVTLSTGERIANPRHERRDRKRLARAQRALSRKAKGSANRAKARLRVARAHARVVDRRRDFLHKVSTRLVRENQTVVIEDLTVGNLVKNGSLARAISDASWRELRAMLEYKAAWYGRDLVVIDRWFPSSKLCSACGARQEAMPLHVRDWACGCGTVHDRDVNAAKNLLAAGPAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DD01</accession>
    <name>A0A1H6DD01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82585">
        <property type="protein sequence ID" value="SEG82585"/>
        <property type="gene ID" value="SAMN04489712_11547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="22765" checksum="2730C6041D98A553" modified="2017-01-18" version="1">MPNPAHATGTDLLVLHALRCVGFAGLARVSEAVGLPEPDVESELIDLAVAGLVTRVPGDFGGWGLTEAGRAADAERIRDELDTAGVRTAVTRAYEDFLVLNPELLDLCTAWQMRSVDGVIAPNDHTDPGYDSRVLERFADFHRRADAVCAELSAALLRFQRYRDRLADALARARSGALDYVVDDMGSYHTVWFQLHEDLLATLGIPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEV3</accession>
    <name>A0A1H6DEV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">kynU</name>
        <name evidence="7" type="ORF">SAMN04489712_11632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>H2O + L-kynurenine = anthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83592">
        <property type="protein sequence ID" value="SEG83592"/>
        <property type="gene ID" value="SAMN04489712_11632"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061981">
        <property type="term" value="F:3-hydroxykynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="PTHR14084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="104"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG83592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="45278" checksum="4AABC8B4AC778F2A" modified="2017-01-18" version="1">MPKGTLREVKMEPSREMADRLDTVDELAPFRKEFNLPAGVVPLNGNSLGPLPAAVPGAVAEAVRQWGERLTRAWNEDWWHAPARVGDRIGRLIGAAPGQTMAGDSTSVQIFNAVVAAARLRPDRRVVVADAGNFPTDRYLTASAARLLGLEVVEVPMGDLPDAVDRHRDEVAVVFCPAADYRTGELWDVPAVTRVAHEAGAVALWDLSHGAGAVPLWVDDDGVDLAVGCTYKYLSGGPGSPAYGYVAARHQDRLDLPLTGWHGHARPFDMAGVFEPAPGVARARIGTPPVLSLLALEAALEPLERAGIEAVRAKTVRLGDFFLGCADRLLDGLGFEVVTPRDPRRRGGHLALRHPEAAAVMAALKDRGVLGDVRGDLLRFCVNGLYVSFGDVHDAVTALREVAATDEYRSPRFRRREVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DH41</accession>
    <name>A0A1H6DH41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Imidazolonepropionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_116103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83926">
        <property type="protein sequence ID" value="SEG83926"/>
        <property type="gene ID" value="SAMN04489712_116103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="56"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="413" mass="44167" checksum="B3CFEFCE393579A1" modified="2017-01-18" version="1">MAERTLLTNARVLTCTGDRHERPIAADVLIEGDRITRVAPGIEAGPARVVDLRGATVLPGLGDAHTHISWPLDFVFDHATVAAAPPAPHILDVAAVTRTYLESGYTFIIGAGTTQPMDDLLVKDAIDRGLLPGPRIVPSGPMIAEAGGLGGDGEIMEVVANAAELRENVAWQCGMGVRALKLFISGDGVVPEFPSEDVYMNDEMLLAAAEEAGRHGAFLTTHARGSASVAMAARTGVRIVHHACFLDDEALKALEARRGDIWVCPGLHYLYAVVNGHAEPYGITPEKVEASGYHEEFRSQVEGLHRLREAGIGILAGGDFGHQWTRHGTYAAELQRYVELAGMTPAEAVHTATRNMGEAAGLPLGQVREGYLADLLVVDGDPSADVTVLQDPARRRAVMKNGRFAYVNPEVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHB3</accession>
    <name>A0A1H6DHB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84768">
        <property type="protein sequence ID" value="SEG84768"/>
        <property type="gene ID" value="SAMN04489712_11765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="145"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG84768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="358" mass="39444" checksum="865FCA92C874DA76" modified="2017-01-18" version="1">MRPAKIEPVSVQEAVDRYVEMVRAKTLTGQFSPATAEVYCRDVGTFAELAGPGRVLDELDGADVDAVLLAFARRADGRRRDGQALDERGREGRRVGEAVQSAASQARFRRSVSVFFRYAVTAGWVQLDPMQAVTVSARQRGGLRAERRALTVEQAGGLVGAAQRLADDGGGHGQGRRRDQRTELRDALVVLLLATMGPRVSELTRANVEDFFVNDGDRYWRIFGKGGRTRDVPLPRPVARVLEAYVERGRPVLDRGMEPKALLLSWRGRRLARGDVQAVIDRVLARVEPSRRRQVTPHGLRHTTATHLLAAATDMDAVRRVLGHADLSTLGRYRDELPGELEAAMRIHPLLRGGPGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIA0</accession>
    <name>A0A1H6DIA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">SAMN04489712_11791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84911">
        <property type="protein sequence ID" value="SEG84911"/>
        <property type="gene ID" value="SAMN04489712_11791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG84911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="22756" checksum="17A063A02250A5EB" modified="2017-01-18" version="1">MTGGHRGEARYIVPSFVERTTYGIKEMNPYNKLFEDRIVFLGTPIDDTAANDVMSQLLSLEGMDPDRPIALYINSPGGSLTAMMAIYDTMQYIRPEVETTCIGQAASAAAILLAAGAPGRRAALANSRILLHQPATEGGRGSAGDLEIQAREILRMRTVMEEIIARHTGQDPAQVSRDVERDRFFTAAQAREYGLVDEVLTSRRRPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIT8</accession>
    <name>A0A1H6DIT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_117139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85111">
        <property type="protein sequence ID" value="SEG85111"/>
        <property type="gene ID" value="SAMN04489712_117139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="395"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="475" mass="51314" checksum="0F3787EDB64759C9" modified="2017-01-18" version="1">MTWETIPQLVQSAGDRFGDAEAVVDGPLRITFAELAERVRVAAGAFAAAGVERGDRVVVWAPNSAEWIVAAFGLVTAGGVLVPINTRWKAAEAADVIVRSRAKAVLVQQGFLDQEYAAPAGVPMIDLKSGFLSSGSPLERKVSGEDIADILFTSGTTGRPKGVMMNHLQTLRLYSEWCDLADLREGDRYLAVNPFFHTFGYKAGCVASMVRGATVIPVPVFELDRVLELVEREKVTMLPGPPTLYHSLLSVRTDRDISSLRAAVTGAADIPVELIRRIRSELPFQTIMTGYGLTEAGTATASRLGDSFEDIATTVGTPCDGVEVRIADDGEVLVRGYSVMQGYLDDPEATAEAIDADGWLHTGDLGSLDERGYLRIVGRKKDMFIVGGFNAYPAEIEGFLMEHPAVAQAAVIGVPDERMGEVGKAFVVCSGPLTAEELIAWSRDRMAGYKVPRHVEFLEELPLNATGKVDKARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJS9</accession>
    <name>A0A1H6DJS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crotonobetainyl-CoA:carnitine CoA-transferase CaiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_117135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85093">
        <property type="protein sequence ID" value="SEG85093"/>
        <property type="gene ID" value="SAMN04489712_117135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="36916" checksum="5511C98983B51851" modified="2017-01-18" version="1">MTGGPLAGIRILEVGHILAGPYATMLLADLGAEVTKIEPPSGDLSRQVGDAYFASINRNKRSVRLDLTTEAGRARLGELVAESHALLVNLKPSAIRRLGLTYDVLRAWNERIVCVALTGFGLAAGDEPAFDYVVQAATGVAALTGDPEGPPTLPGYSSADNSAGMAAALGLLAQIVSGRGGQVEVSLRDVMLSQLNYKASAYLNEGAEPRRLPFGAHSYYVPAQLFPTAEGYLALFVTHDGFWRSFAAEAGVEGFPTMAERAARREEVLAAVTKALAADTALGWESRLRPLGVPAAAVRTLPQALEATPEMVVTAGDFRLVGSPIRIAGYEPAYGPPPRLGEHGDLPERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKB9</accession>
    <name>A0A1H6DKB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85728">
        <property type="protein sequence ID" value="SEG85728"/>
        <property type="gene ID" value="SAMN04489712_11868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="28790" checksum="45478DCEB87B63B2" modified="2017-01-18" version="1">MSFPLDVLDLAESRRLGEPVRAFDARPDFRRAVTWLVLLGPAGVLLVASSLFYLVVGPRWLGAVGVLLAAAYLGGVGSIVRGAALRGRGLAVYAFEDGLVRLTPRGTSAHRWDELHSVTMAMVRPASRGRRTQWRFTVTGADGAHFVLGDELPGVRDLGEAIVAEVARRELPRRLAEVEEGRTVRFGPFTVDGTGVGKDGEDGKDGEVVPWESAGESGIGNGQVYVRRSDGTRAMSAAVGLVPDALVFVGLCRRMRDTAGSVPARRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLW6</accession>
    <name>A0A1H6DLW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type nitrate/sulfonate/bicarbonate transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86179">
        <property type="protein sequence ID" value="SEG86179"/>
        <property type="gene ID" value="SAMN04489712_1198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296034" evidence="1">
        <location>
            <begin position="28"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="65"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="365" mass="38041" checksum="FEB0186802500496" modified="2017-01-18" version="1">MRRVPARSATAVAAALLVLSGTLVACASPQGGNSEADKRPEAEICPTADTKGTIKIGMSSPLAVFAPLLLGVETGEFSKAGIDIEIKKIPSAESLPLVARGQLDAQMTSLSSAHFNTLKDGVDVRWIVPMDDQQEIPPGTPVPGYWSRKDVVGSATSPDLSKLKGADVSTPTGGTGVSGLILDNALSKVGLGIKDVKLVSPLVGPDALNGLANGAVSAAWISAPLEVEAAKNPDLVPIAGYEPGVTGTAIMAGRALLDRPELAVKFTQVLSKVTKKYLTGDYRQNPETVRLLAAAEEVEESTIKNSALLVFDPSFSMDGTEKFADALQEFALKRGELEYDKPLDSADLIDTRFTKAAASCASVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMB0</accession>
    <name>A0A1H6DMB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85705">
        <property type="protein sequence ID" value="SEG85705"/>
        <property type="gene ID" value="SAMN04489712_11863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="37"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="162" mass="17468" checksum="0E0679104DFB8FD0" modified="2017-01-18" version="1">MITAALLASAGASAKVRSLEMVRFPAGDAAPDGRVNVREVRAYLRRTLDGTGVDLDDMDLMAAEVVTNAVRHTTSGRPGGRVWVAVITEDARVRVETTDEGGATTEPMIPPCQVLSGRGLLIVERLSDRWDWSRDGKGRTTVWFELLRGEETAITSTAEGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMP0</accession>
    <name>A0A1H6DMP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86411">
        <property type="protein sequence ID" value="SEG86411"/>
        <property type="gene ID" value="SAMN04489712_11976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="33354" checksum="066FE78CAD183691" modified="2017-01-18" version="1">MYDMIVVGGGPAGLSAALVFGRQRRRVLVVDGGRVRNAPATEMHMYLSRDGFPPARLLELGRAELAAYPSVEIRPGTARSARGKKDDFEVELDDGTVERARRLVLATGQVDEPYPIEGLRERFGRGVYHCPFCHGWETRDRSLAVLTREPMEAMLALYVADRFSDDVVLCTHGPLELPAEIAAKLDERGVRVIDAPVARVTGEPGALELHFTDGTTLVRQDVYHRAPTRQHSALAAELGCELNDDGTVRVNEMQETTVPGVAATGDTAKLPAVPDAVTLVSQGAADGVRAAVWMEGDLFRSDLGLSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRC7</accession>
    <name>A0A1H6DRC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87927">
        <property type="protein sequence ID" value="SEG87927"/>
        <property type="gene ID" value="SAMN04489712_12138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="33305" checksum="E9BB930BD95D60BC" modified="2017-01-18" version="1">MTRPRTVPVRGGRRRHELASFLRSRRERITPEEVGMPSGSRRRTPGLRREEVAQLAGVGVTWYTWLEQGRPINASAQVLDAVARTLRLDAAEREHLYRLADVPQPPPATDETHALPQDMRTILDNLDPLPAALLNARSDVLSWNQAFAALFPGMVNTPAAERNAVWFVFTTPPCCNPILNLEEQAPEQVAIFRYRYSRHLHEPEWQEFVQRLCKASPEFARLWATHDVAPPRPCDKVFRYPAVGDVATRSTNLEVTALPGARLVVYTPVDDESRERIAWLRDHPEATAPDHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTX0</accession>
    <name>A0A1H6DTX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, DUF305 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88156">
        <property type="protein sequence ID" value="SEG88156"/>
        <property type="gene ID" value="SAMN04489712_12187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296217" evidence="1">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="46"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="23546" checksum="5B28B693038A813D" modified="2017-01-18" version="1">MSRRHLAGRVLSAAGLMVIGAVAAMLLLGAGRAADRAPIPAAGPVDVGFSQDMIAHHQQAVTMAQTVRGRVSPPVAQLASSIELNQTREIGQLQGWLMLWNAPQVPSGPPMTWMAADRAGHSGHRRATDADVVMPGMASQQEVNRLGELTGEDADAWFLQLMIRHHQGGLAMTTAAARDATSPQVRALATLMTTEQHKEVATMAGLLDALGRRPLPAPTSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUW9</accession>
    <name>A0A1H6DUW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89040">
        <property type="protein sequence ID" value="SEG89040"/>
        <property type="gene ID" value="SAMN04489712_1237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296312" evidence="1">
        <location>
            <begin position="29"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="110"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="339" mass="36339" checksum="7D30E6B1661D4791" modified="2017-01-18" version="1">MTMGIRTITAAAAAIALAAAACSGTSDEARKAGGHRSASTSARPVNPAAVRANELGQIPVLMYHRIAAHPAAIHDRTPADFRAELDRLAREGYVPITAAEYVTGRIDIPAGKHPVVLTFDDASVSQLTLSADGKPRPDTAVAILLDAGRRHPGFRPVATMFVNSRPFNEPGGRRTLTWLHEHGFEIGNHTSTHANLGTSDAAKVRREIAVNQRDIIAAVPGATVRTLALPFGIQPKPPALAVRGEDRGIRYEHKGVFLAGANPAPSPFDASFDPYNIPRIRSQGAHGEEANYASTQWLDRLATEEGNRYTSDGDPARISYPRYGTGQIAPAWKKAARPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVD9</accession>
    <name>A0A1H6DVD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89024">
        <property type="protein sequence ID" value="SEG89024"/>
        <property type="gene ID" value="SAMN04489712_1231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="107" mass="12029" checksum="0C717C818CDAFED4" modified="2017-01-18" version="1" fragment="single">DQSREAAGKDWTDTGLIFTTRTGQPINPHNFNRSFDQRCAKAGVRKITVHDTRHTCATLLAALDVHPRVAMRVLRHAQIAVTMEVYTEVSDAKTLKALKRLGKQFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVP7</accession>
    <name>A0A1H6DVP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,5-dihydroxypyridine 5,6-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88796">
        <property type="protein sequence ID" value="SEG88796"/>
        <property type="gene ID" value="SAMN04489712_12281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="338" mass="36741" checksum="5C8CE263F19D2074" modified="2017-01-18" version="1">MPKTLRELFVDQYRLCRLTSSETVAVISELGHKDEYVQAAVAAARDLGAGALVLTASSLSNPLLPPHEGDGREVAALLAAAAECDLVIDVTVGGLIHSDVRTRITGNGKRMLFVAEPADVLERLMGDEKLRAVVEAGGRRLKAGSTLRVTSAAGTDLTADISGEDLPITHQWGYVDEPGRWDHWPSGFVACFPHDLTAQGTIVLQPGDVLIPWQRAVRDTVTLTIEKGFITGVEGSGNDAFVLRDYFEAWDDEAVYAVSHMGWGVHPIARWSALEVYDPRSLYGQELRSTAGNFMWSTGPNRFADRETPAHLDIPMRGCTVEIDGHAVVRDGVLVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DW28</accession>
    <name>A0A1H6DW28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="11" type="ORF">SAMN04489712_12358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89284">
        <property type="protein sequence ID" value="SEG89284"/>
        <property type="gene ID" value="SAMN04489712_12358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG89284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="42234" checksum="12D1B3622FA4FF28" modified="2017-01-18" version="1">MLALRAVLSRIYKGEVSADIVGRPRLWYSLSALLLVFSIAGLVVRGLSFGVEFTGGSVFTFKAPNASIEQVRTTVAEAGPHQVIVQQTSSGWRVTTESLPSAEVAEVQQAVGEEFGLPAGQVSSQVIGSTWGDEITKKAWQALAVFMLLIVLYLSLAFEWRMAVAAMVALVHDLVITAGVYAWSGFEVTPATLLGFLTILGYSLYDAVVVFDMIKEVTRDLGSPGKLKTYSQAANEALNHTLVRSLNTSLVAILPVASILFVGTFLLGAGALKDLSLALFVGIVVGTYSSLCVATPLLVQLKEREPRYRELRERLRSREAGAKRRARKAAVPADRPAAGTKAPAADPPDEDAGRAGDGSAAAEPESSRKVKVVQTGPRRQPRRGTRQQRRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWW1</accession>
    <name>A0A1H6DWW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89832">
        <property type="protein sequence ID" value="SEG89832"/>
        <property type="gene ID" value="SAMN04489712_12482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="213"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="30181" checksum="AA9BB2988E15AF73" modified="2017-01-18" version="1">MTSDSFRIGGDITVRRLGFGAMQLPTEPDEARKASIAVARRAVELGVTLIDTAYLYGWGANEELLVEALYPYPDEVLITTKVGVVPPDPPREAALCGRPEVLRDQVERALRRLRVDRLDLLQLHRIDPEVPLADQVGTLGELQAEGKIGHIGLSEVTVAELDQARQIIDVASVQNRYNVLDREHDAVLEACAAAGIAFLPWRPVLPAAAEPPGEIATVAAELGATAAQVALAWLLDRSPVVLPIPGTASIEHLEENVAAASLRLSDDQRSRLNATRPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXG9</accession>
    <name>A0A1H6DXG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89774">
        <property type="protein sequence ID" value="SEG89774"/>
        <property type="gene ID" value="SAMN04489712_12460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="122"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="29215" checksum="8BCF1E60BC46E7E2" modified="2017-01-18" version="1">MSAVLTGLNVYPLKGGGGTVLTSAELEPKGLRYDREFMLVTPEGRFLSQRDLGLMALLRPSYDGEVLTVRVADPAASPAPLVHKATEDGPVREVYVHRSQCEGVDQGDEAADWFSALLGVDCRLVRFTGHRETGRGGGEVAFADAYPLLLISEESLADLNGRLARSGSGEHTPLPMNRFRPNLVVSGLGAFGEDSVKLLRVGETVVELVKACARCVVTTTDQDTGERGREPLRTLASYRTIGRGIRFGQNGIPRTPGTVRVGDPVEILETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY98</accession>
    <name>A0A1H6DY98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89743">
        <property type="protein sequence ID" value="SEG89743"/>
        <property type="gene ID" value="SAMN04489712_12448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG89743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="24882" checksum="1621B4F1F7609A74" modified="2017-01-18" version="1">MNFLDPQSLIVTFGVIGILAIIFAETGLLFGCILPGDSLLFAAGVFTVGSAASGIGLDQPLSLPVLLVGGPLCAIAGAQLGHWLGAKYGRRLFDRPDSKIFRQEWVEKAEHYFDKFGPAKAVVLARFIPIVRTFLNPLAGMLGMDARKFFLWNVIGAVLWTDGLFLAGHFLGSKIPNIETYIMPGIVVIVLLSIIPIVREVMKGRREARLNADKNAAEQSRASLSGDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYN6</accession>
    <name>A0A1H6DYN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_12449</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89745">
        <property type="protein sequence ID" value="SEG89745"/>
        <property type="gene ID" value="SAMN04489712_12449"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG89745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="36613" checksum="44835E8DD0567407" modified="2017-01-18" version="1">MPIATPEVYAQMLDRAKQEGFAFPAINVTSSQTLNAALRGFAEAESDGIIQVSTGGAEYLSGTAVKDMVTGSVAFAEFARVVADKYPVNIALHTDHCPKDKLDGFMRPLVKISQERVAKGLDPLFQSHMWDGSAVELHENLQIAAELLEECAKARVIMEAEIGVVGGEEDGIVGEMNEKLYTTVGDALATAESLGLGDKGRYMLAATFGNVHGVYKPGHVKLRPEVLKEIQEAVGAKHGQDKPFDLVFHGGSGSSLEEIREAISYGVIKMNIDTDTQYAFTRPIADHMFRNYDGVLKVDGEVGNKKQYDPRSYGKAAEAGMAARVVTACENLLSAGKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZV9</accession>
    <name>A0A1H6DZV9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin carboxylase</fullName>
            <ecNumber evidence="1">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_1261</name>
        <name evidence="9" type="ORF">SAMN04489712_1271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="de Groot N.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.14" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90320">
        <property type="protein sequence ID" value="SEG90320"/>
        <property type="gene ID" value="SAMN04489712_1261"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90659">
        <property type="protein sequence ID" value="SEG90659"/>
        <property type="gene ID" value="SAMN04489712_1271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="119"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG90320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG90659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="41666" checksum="DAB7A720CC2DAB12" modified="2017-01-18" version="1" fragment="single">MRKVLIANRGEIAVRIARACRDAGLASVAVYAEPDLDALHVRVADEAYALGGRTAADSYLDIDKILKIAAEAGADAVHPGYGFLAENADFAAAVQAAGLTWIGPPPAAITALGDKVQARHIAQKVGAPLVAGTKDPVAGAEEVVAFAREHGLPIAIKAAYGGGGRGLKVARTLEEVPELYESAVREAVAAFGRGECFVERYLDRPRHVETQCLADRHGNVVVVSTRDCSLQRRHQKLVEEAPAPFLTDEQVALLYGSSKAILKEAGYVGAGTCEFLVGQDGTISFLEVNTRLQVEHPVTEEVTGIDLVREMFRIADGEELGYGDPPMRGHSIEFRINAEDAGRGFLPAVGTLSAWRPPSGPGVRLDSGYEEGHTVPQEFDSLIAKLIVTGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1G3</accession>
    <name>A0A1H6E1G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ricin-type beta-trefoil lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1H6E1G3"/>
    <dbReference type="EnsemblBacteria" id="SEG91402">
        <property type="protein sequence ID" value="SEG91402"/>
        <property type="gene ID" value="SAMN04489712_1296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="968"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1272" mass="137153" checksum="685FB22DB1A315D8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4M7</accession>
    <name>A0A1H6E4M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92577">
        <property type="protein sequence ID" value="SEG92577"/>
        <property type="gene ID" value="SAMN04489712_13439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="23939" checksum="4F1DC1FE88A20765" modified="2017-01-18" version="1">MTDTRTRLLEAAERLYAERGIDAVSLREINQAAGARNAVAVQYHFKDRAGVLRAIMARHLPDVDARRHALLDAYEAAGEPDVRALAAALVRPPAAKLADPDGGRHFLQIWAELVSRPQGPPGRVPADPGEIGGSLHRWRALVEPLLAEDAARLHRRYTAILHAAIELARRARSGPHSDDRLFTSYLIDVVTAILAAPVSAETRRLAAERDAARTRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6W6</accession>
    <name>A0A1H6E6W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-ketosteroid 9alpha-monooxygenase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93470">
        <property type="protein sequence ID" value="SEG93470"/>
        <property type="gene ID" value="SAMN04489712_1397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="265"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG93470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="354" mass="37331" checksum="DEB7C7AB69E35D47" modified="2017-01-18" version="1">MTSAGALKARVVEVVRETAEAHSLVLEPAEGDRDRFSYRPGQFLTVRVPAEDGWVARCYSLCSSPVSDDRLKVTVKRVAGGLGSNWICDNVTEGDVLEVLRPAGTFTPASLDEDLLLIAAGSGITPVMSILKSCLAAGAGNVVLLYANRDERSVIFADELRDLAAEHGDRLTVVHWLESVQGLPTAAALRSLARPYAGRETFVCGPEVFMDMAGSALTGLGVPAGRVHIERFFSLAGDPFDPAVPEEGEDADGADGADGSAEGAAEVEVEIDGETRTVPWPRSQRLLDVLLRAGVDAPFSCREGSCAACACVVVEGEAAMDANTVLDAQDLADGLLLACQARPVSDRLKVSYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8C4</accession>
    <name>A0A1H6E8C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_14213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93970">
        <property type="protein sequence ID" value="SEG93970"/>
        <property type="gene ID" value="SAMN04489712_14213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="121"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG93970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="41494" checksum="43CF7B405B77977D" modified="2017-01-18" version="1">MTATEIRPAGKASLPAGRGRTRRGGMTRYVLARVARLLSIIAGVTFISFFLLKLTPGDPVATALGPEATPEQVERLRASLGLDRPAWEQYLDWLGGVLHGDFGTTLTQPSRPVGGELAARLPVTLQLIALTIVLSLAISIPLAVWSAHRAGRTFDRAVSSVLYGLVALPGFVAALLLVLVFVFHADAARTAGLAVAGAALAMTVVAALRSRRARSSPLPPLIGGGAVAAVGLAVYALLPDFPRQGFVPLGEGVGANLTSVALPVIALTFVDIAVFTRLLRGDMITELAKPHVLASRAKGMSTAHVLLRESLRPSMFSLITVVGLTIGQLIGGTIIVEHIFRLPGVGSLLVASVRNGDHPVVQAAIFVIATVYVTVNSLIDIAYAYLDPRVRQVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9F1</accession>
    <name>A0A1H6E9F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_14026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93739">
        <property type="protein sequence ID" value="SEG93739"/>
        <property type="gene ID" value="SAMN04489712_14026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="130"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG93739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="43148" checksum="E0F4D878DCEB4826" modified="2017-01-18" version="1">MDLTYSAADEAFRLEVRDWLAAHLSGDFAELRGLGGPGRENQAFDERLEWDRYLGAHGWTCLGWPTEHGGRGLSLARQIIFHEEYARANAPARVNHLGEELLGPTLIAFGSPEQRRRFLPEIVAVRELWCQGYSEPGAGSDLASVATRARLDGDEWIIDGQKVWTSLAHHADWCFVVARTVPGSRRHDGLSYLLVPMRQDGVEVRPITQLTGTSEFNEVYFDGARTEASLVVGTPGDGWKVAMATLGFERGISTVGQQIGFARELDAVIDLARRNGAIDDPVICDRIAHARMGLEAMRLHALRTLAGDASTGPAQASVSKLVWANWHRGLGELAMQVAGAPSLVVQASPYELDDLQRLFLYSRSDTIYGGSNEIQRNILAERVLGLPREARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9J8</accession>
    <name>A0A1H6E9J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94498">
        <property type="protein sequence ID" value="SEG94498"/>
        <property type="gene ID" value="SAMN04489712_1487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="79" mass="8534" checksum="1CFB506BFD1429BC" modified="2017-01-18" version="1">MHERIGPAIGDMNRAMHEVRLDGPGKVSAATDHLRSRARRVQALLKALIGDGGPGQWDAYDADDTVLAAFGKVRNRAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB23</accession>
    <name>A0A1H6EB23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94134">
        <property type="protein sequence ID" value="SEG94134"/>
        <property type="gene ID" value="SAMN04489712_14319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="7963" checksum="C9B7E1A90FA7221D" modified="2017-01-18" version="1">MSKIRNSITWKEVSERMANFMINFEGGDHGRHACRWRARLALHWKRSANGLRARLTWNFTRFWGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBY9</accession>
    <name>A0A1H6EBY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000047">
        <property type="protein sequence ID" value="SEG94424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94424">
        <property type="protein sequence ID" value="SEG94424"/>
        <property type="gene ID" value="SAMN04489712_14716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="259"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="358"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="447" mass="46771" checksum="9A41A967B1DCA840" modified="2017-01-18" version="1">MEVVPFRTPGLGDTSYLLVHDGTGVLVDPQRDIGRFLDAVAERDVALRFVVDTHLHNDYLSGAEQAAARTGAELVLPAGAAAAYPHTPAFHMEDIKGDKGLTLRPVHTPGHTPEHTSHLVLIDGEPVAVFSGGSLLVAAAGRPDLLGPERADTLARLQYRSLHRLAGLPRDVLLLPTHGEGSFCTAGGAGRLTSTIGEELDANPLLSTRSEDEFVGRLLAEPQPIPAFYRHMSPVNVRGVPPMPPVDVPVLDAAGLAGLPEETQLVDIRPRETMAAGFVPGSVGIELADDFGAWTGWLLPYGAPIALVAEPGQDVAEAVTQLARIGLDAVVGVITDLTGVGTARFRVVGLDAFAALARRPGAQVLDVRMPSERETVAVPGSIWRFLPDLFTDGVPAELDPARPVLVACGSGRRAAIAATALHRAGFTPVALTGAGVPELADALKDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S6Y8</accession>
    <name>A0A1H5S6Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45678">
        <property type="protein sequence ID" value="SEF45678"/>
        <property type="gene ID" value="SAMN04489712_10183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009283690" evidence="4">
        <location>
            <begin position="31"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="210"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF45678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="35099" checksum="1AECEFD1177966B3" modified="2017-01-18" version="1">MASEKTRRFWATACLTVATTVALPVATAHAEPTPSASSVQKKLDALNKQVDQLVEKYNQAEEDLKSAKAKLKAARKAAAAEAADFEKTRARIAEMAATAYKNGDMGDVAGFVGTGDPQNVLDQTAVFAHLSRNRSSELTVFLAAAQRLQRQQAQAQEAYDDVLRRSKELKEQKQKVEKSIDTQEKLLSRLGVTPDRPSGGGGGTYTGPASGSARVALQFAYAQIGKPYQYGAEGPNSYDCSGLTMRSWGAAGVNLPRTTYSQYSATKRVAKSDLQPGDLVFFSSLGHVGLYVGNGQMVHAPRTGKNVEVVNITSGYYATNYYGAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SHQ3</accession>
    <name>A0A1H5SHQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan/xylan/chitin deacetylase, PgdA/CDA1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50149">
        <property type="protein sequence ID" value="SEF50149"/>
        <property type="gene ID" value="SAMN04489712_101216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284030" evidence="1">
        <location>
            <begin position="33"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="83"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF50149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="31407" checksum="01AB0D494872E603" modified="2017-01-18" version="1">MRGKIPLVACLVAGVLGVGAGAWPEVRTHAAADTAPSLREDLTALLADQGWERPKPGSWTVEQAADIPRGPVPTIRKITTQDRVVFLTIDDGYEYDPEFVKLVRQHKVPILTFLTSTYVKGQGQYFWSLRNAGSRMENHSVTHPAMNTLPLEQQRKQICDASATITQQYGMRPVFFRPPFGAMNELTQQAAKECGIKLIMLWNTEFYNGTTGPGVGFNGFARGDGGGKGFQPGDIVLMHYRKGLAQQFQMILGWIRQQGFRPAAIENYIPRSLGGNAPDTATTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SP55</accession>
    <name>A0A1H5SP55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52224">
        <property type="protein sequence ID" value="SEF52224"/>
        <property type="gene ID" value="SAMN04489712_101297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF52224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="23381" checksum="869B4AF1D7D8DC62" modified="2017-01-18" version="1">MIRVLLVDDQPLIRAGFRALLEAEEDIEVVAEAADGLRGVELAAAHLPDVALIDVQMPVLDGIEATRRIAADPRLSGVHVVILTNYGLDEYVYDALRAGAGGFLVKDTEPADLLHGVRVAARGDALLSPAITRRLIGEFVARPLDGRVGAGLAELTNREREVVALVAGGLSNDEIAEHLVISPVTVKTHVSRAMTKLHARDRAQLVVFAYQARLVTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SRC2</accession>
    <name>A0A1H5SRC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trp region conserved hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52970">
        <property type="protein sequence ID" value="SEF52970"/>
        <property type="gene ID" value="SAMN04489712_101327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019051">
        <property type="entry name" value="Trp_biosyn_TM_oprn/chp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09534">
        <property type="entry name" value="Trp_oprn_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF52970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="20676" checksum="6AFFC38D374A84FA" modified="2017-01-18" version="1">MNPGRERAVAALLCAVGAGLVLLAGGREWATVRASGAITPIGRTLTGGDLAGATTALGWAGLAALAALFATRGRVRAAVGALLVLLGAGAAYTAATGIGRAHVLAVAEERSTLLRLGGDLVVATSWWWAVSVAGGVLLAVAGLLTLARGGRWPGMSARYDRPGTGRAPAGASGAAGAAPGDPASLWKSLDRGEDPTLDGDPPGPGRATND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T9K9</accession>
    <name>A0A1H5T9K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59479">
        <property type="protein sequence ID" value="SEF59479"/>
        <property type="gene ID" value="SAMN04489712_101536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF59479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="36554" checksum="D09B7B9E1BCFB863" modified="2017-01-18" version="1">MDVIALGDPTDAQIEEWQAVVAAVWAHDHPGEPVPELEQTRARLLVPPMASRNLMWAARDSGGRMCAVAYLRLPEDTGRSGEIDVQVLPAYRRCGLGTRLLAVAADGLRAGDCKTVIVQALAGTPAVPFLEAHGFHCVLSLRAMLLSMDDVAPDRLARLLAEGPSGYRLIRWTGTVRDELAGELAMAKRAMADMPLGGLSGGSFRWDADRVREMAEAVAARGDLLYTVAALHGPAAVPRIAGFTEVVVPAAAPERALQYDTAVVPEHRGRRLGIWLKAAMLEWLRAERPDVREIETDNADDNSHMLAVNEELGFRHQRDYLDYQADTADLPTTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TGI2</accession>
    <name>A0A1H5TGI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61919">
        <property type="protein sequence ID" value="SEF61919"/>
        <property type="gene ID" value="SAMN04489712_101611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040611">
        <property type="entry name" value="TetR_C_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18556">
        <property type="entry name" value="TetR_C_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF61919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="196" mass="21674" checksum="8CDEF4483634A6E4" modified="2017-01-18" version="1">MTTGRRCLRDELLDAFAELLTLRGYRGVRMQDVADAVGVSRQTVYNEFGDKWRLAQALVIRDNEQYLDGIDQVLSQHDDLYSAVAAAVAYTLEMSADDPIKKAVLTGTGGEELLPLLTTQAEPVLFGAKARLIEHVAAQWPHLDRQALAEVADAAIRLTMSHMLLPADPPERVARQIARLVARYQGEPCPPPEGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5THA7</accession>
    <name>A0A1H5THA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62143">
        <property type="protein sequence ID" value="SEF62143"/>
        <property type="gene ID" value="SAMN04489712_101618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="167"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF62143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="372" mass="41414" checksum="3FED96C261CCB1BD" modified="2017-01-18" version="1">MRETPPFRADHVGSLLRPPELLRARADAAAGRIGPGELRAAEDAAIRSVLALQREAGLRSATDGEFRRTSWHMDFIYRLGGIDPADEQIKVSFRNADGDLEFTTAALRVHDRVRLEETVFADAFTFLRDELAGTGVTPKLTIPSPNMVHYRGGPAAVDPRVYPDVEEFWSDLSAAYAEQVRRLGELGCRYLQFDDTSLAYLNDPAQRRMIAERGDDADHLHLRYIRQINDALAGRPAGMAVTTHMCRGNFRSSWTAEGGYDFVAEALFNELAVDGFFLEYDDARSGGFEPLRFVPKGKMVVLGLVTTKRGALESKDDLKRRIEEASRYVPVEQICLSPQCGFSSTVEGNALSREEQAAKLRLIVETAEEVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TI62</accession>
    <name>A0A1H5TI62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62499">
        <property type="protein sequence ID" value="SEF62499"/>
        <property type="gene ID" value="SAMN04489712_101630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF62499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="311" mass="32733" checksum="C92C829DB09FC95C" modified="2017-01-18" version="1">MNCVVAALAAVCLYYLGAAFFKVAAGRMEPLHGRRPVHLIRQVLSDRLWVTGLLVFTVGLELQIVAFAELSLGPAQPLFCSTLLFLLVICLGYFGERLVPREWAGLGLFAVATMCIALSVPTGDDPIEGLPPTPTVVPVAALSLAVPLLLFPLVGRHATGRHARPLAGIAYGLICGLLLGTGEVAVKGLSIANGTRAHGLSLLAEPYLYLTLVAAGLGLCQGTIALQRCRMAIPMVVCTIVAKTYLLVVGSWLYGVGWPSDPLSGHLRLIGVCLAIGALFVFPRHERPRSPVPAAPLATAGPVVSLGSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TJ56</accession>
    <name>A0A1H5TJ56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NitT/TauT family transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62912">
        <property type="protein sequence ID" value="SEF62912"/>
        <property type="gene ID" value="SAMN04489712_101643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF62912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="31169" checksum="7128BD5FE462CD87" modified="2017-01-18" version="1">MSRQTPSTTAPVPGAPSGTGGPDTPARRAGPGAGERLAAAAERTWRPVALLAACLAAWWAVSAARLVEPYLVPSPGTTLQVVRDRAGYLLEHSWVTTYETLLGFAIAVVLGVLSAVLMVHSAELEKTLYPVLLFAQVIPKIAIAPLFVVWLGFGITPKIVVAVLIAFFPVVISMVTGLKSIDPEMLELSATMGAGPWRTFAKIRFPASLPHLFAGLKVAVTLAVTGAVVGEFVGANEGLGYVILQANGNLDTPMLFAGLLIMSLLGVVLFALVELAEKVLLPWHASRRADSVTTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V2L5</accession>
    <name>A0A1H5V2L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CO or xanthine dehydrogenase, FAD-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81474">
        <property type="protein sequence ID" value="SEF81474"/>
        <property type="gene ID" value="SAMN04489712_102134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF81474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="31055" checksum="A3D5DD6000991261" modified="2017-01-18" version="1">MEFLRPLSWEEALALRAGRPDAVPIQGGTDVMVEINFEVRRPGALLDLNPVRELAEWEMAEGRLRIGAGLPYTRLIEEVGDRVPGLAQAARTVGSPQIRNRGTVGGNLGAASPAGDCHPPLLAAGAQVEVESAAGGVRMIPAEEFYLGVKRTALRDDELIRAVWLRPAEGPQHFSKVGTRNAMVIAVCSFAIALHPAERRVGTGIGSAAPTPLRAAEAEEFLAGELAGEPAWGRSLPDGLAERFGELVGRAAAPIDDVRGTAAYRRHALAVMARRTLTWAWQDRLAGTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V5F6</accession>
    <name>A0A1H5V5F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81988">
        <property type="protein sequence ID" value="SEF81988"/>
        <property type="gene ID" value="SAMN04489712_102154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF81988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="7017" checksum="E12EC823FF6AB91A" modified="2017-01-18" version="1">MAYRRGPGISLIGLIYLIIGVFVAWDRDYIDLDLLRRVGSALLAIFLWFLVLLGVDLHIDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VBI4</accession>
    <name>A0A1H5VBI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83817">
        <property type="protein sequence ID" value="SEF83817"/>
        <property type="gene ID" value="SAMN04489712_102220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF83817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="63" mass="6732" checksum="CDE056C763EB3CBC" modified="2017-01-18" version="1">MSSKTKVVLGGVALGLIALWLIPGWILTLVVLGVIAVPVAAYLLLDPSQRRRVRAQGRKRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VX53</accession>
    <name>A0A1H5VX53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91556">
        <property type="protein sequence ID" value="SEF91556"/>
        <property type="gene ID" value="SAMN04489712_102490"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="14"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF91556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="22041" checksum="978CE8C9365C790C" modified="2017-01-18" version="1">MPKNEQTPVVLSRIYTRTGDDGTTALGDMSRTRKSDPRLAAYADVEEANAAIGAALALGELPEDLRTLLVRVQNDLFDVGADLCNPVTDDAAAEYPPLRVQESYVTWLEEACDRHNADLQPLRSFILPGGTPGAALLHVARTVTRRAERSVWTAIEQHGAAPSGTVNPLTARYLNRLSDLLFILCRVANAGHGDVLWKPGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VZ76</accession>
    <name>A0A1H5VZ76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91867">
        <property type="protein sequence ID" value="SEF91867"/>
        <property type="gene ID" value="SAMN04489712_102502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF91867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="85" mass="9457" checksum="B69E596A65699144" modified="2017-01-18" version="1">MVRPAMSGEGRQPDRQPDDWDHQTDHQGFTNAAWSIPSYLLSGMAVYGGIGWLLDRWLGTSALLPIGILVGLGLALYLVYHRYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VZJ0</accession>
    <name>A0A1H5VZJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92438">
        <property type="protein sequence ID" value="SEF92438"/>
        <property type="gene ID" value="SAMN04489712_102524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF92438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="105" mass="10945" checksum="59F47C4E4825547F" modified="2017-01-18" version="1">MGRSRISVNVDLPGRDPNASITLPLDERANCRAFCVTHPEGAEPVLAISHGGVNVMLTPDKPGRVTAGDVATARALLEAVTSYVTDVERLHDQNAPSSGAGRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W1M0</accession>
    <name>A0A1H5W1M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93178">
        <property type="protein sequence ID" value="SEF93178"/>
        <property type="gene ID" value="SAMN04489712_102550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF93178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="47" mass="5216" checksum="06377D46DF2AD7A9" modified="2017-01-18" version="1">MRAADRRDHVLATGDVRRRTGGRRAPARSHTHPHRSDGGLPLPRVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W6Y1</accession>
    <name>A0A1H5W6Y1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsE</name>
        <name evidence="8" type="ORF">SAMN04489712_102605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94986">
        <property type="protein sequence ID" value="SEF94986"/>
        <property type="gene ID" value="SAMN04489712_102605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF94986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="25621" checksum="F4120EF37CD00534" modified="2017-01-18" version="1">MIHFDNVTKVYPNQNRPALQHVNVAIEKGEFLFLVGPSGSGKSTFLRLVLKEERPSQGHVHVAGKDLNRLTNWKVPHLRRRIGCVFQDFRLLPNKNVFENVAFALEVIGKPRRFIAKVVPEVIDLVGLEGKAHRMPDELSGGEQQRVAIARAFVNRPMILLADEPTGNIDPATSIGIMKVLDRINRTGTTVVMATHDAAIVDAFRKRVVELEDGRVVRDQSRGVYGQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WCV4</accession>
    <name>A0A1H5WCV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97409">
        <property type="protein sequence ID" value="SEF97409"/>
        <property type="gene ID" value="SAMN04489712_102676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF97409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="78" mass="8516" checksum="263E5983ACC8C1E3" modified="2017-01-18" version="1">MYFVIGMLITLAVLGPLFGADTRDGLDWAPGNFWLRRRSDGRGRRSHGRPRFTRTDSRAQASAARAVRDGGRTAPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WDJ9</accession>
    <name>A0A1H5WDJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97555">
        <property type="protein sequence ID" value="SEF97555"/>
        <property type="gene ID" value="SAMN04489712_102682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF97555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="107" mass="11558" checksum="63855560DA7CCF0B" modified="2017-01-18" version="1">MSAPIKVTDETFDELVLKSDKPVLVDFWAEWCGPCRMIAPILDEIAAEYDGRLTIAKLNADENPATQAKAGVMGLPTLNLYVGGEVVQQIVGAKPKRALLAAIDPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WY39</accession>
    <name>A0A1H5WY39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_1035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04223">
        <property type="protein sequence ID" value="SEG04223"/>
        <property type="gene ID" value="SAMN04489712_1035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="52"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="326"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG04223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="421" mass="43083" checksum="D974A4BDE379DE3D" modified="2017-01-18" version="1">MIRRAPFRAKGTADGRPAGGRREKTRRSNRLAPRDVLRVGAAGLRARPLRVFLSALGIAIGIAAMTSVVGISSSSRADLQATLDRLGTNLLTVGPGSDFFGKAATLPEQAIGMIGRVPGVRSASGTGKVEDAKVYRNDRIPEGESGGIGVHAARLDLPGTVGATVASGTWLNRATARQPAVVLGSLAADRLGIGAAGPDVQVLLGGRWFTVIGILDPVALAAELDTAALVGWEVAEDRLGFDGHPTTIYTRADEDRVEQVRDLLAATANPEAPNEVQVSRPSDALAAKNATDEAFTGLLFGLGGVALLVGGVGVANTMVISVLERRAEIGLRRSLGATRGQIRGQFLTESQLLAALGGAGGVALGIAVTAIYALTQGWPTVVPAWAMAGGVAATLVIGGVAGLYPAIRAARLSPTEALATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X2I6</accession>
    <name>A0A1H5X2I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen triple helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05517">
        <property type="protein sequence ID" value="SEG05517"/>
        <property type="gene ID" value="SAMN04489712_10347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009288986" evidence="2">
        <location>
            <begin position="36"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG05517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="26396" checksum="72DAE8A081D8FD5C" modified="2017-01-18" version="1">MGLRGKAGLVTLVGLATANGVVLVGGGVAVATAAAAPATIKACVGKSNGATRIVSEKTKCRSNERVVRWNQTGPRGPVGPKGATGPKGAIGPKGATGPQGATGARGPAGPTGSAGARGPAGATGPAGPAGPAGPAGAVGPAGPKGETGPQGPPGPLPDAYRKHQAFHIDVTAAFTKVAWIDLAPGTYSIQAGLHIDEGNARCGISADGAAPDYQQLVTFDGVPGGRWRPLTEIVTLPATGQATLLCSPVPQGGEPTAGADLTAIKVSPRSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XIS6</accession>
    <name>A0A1H5XIS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11533">
        <property type="protein sequence ID" value="SEG11533"/>
        <property type="gene ID" value="SAMN04489712_103271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG11533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="100" mass="10843" checksum="6703F51FB891E7A5" modified="2017-01-18" version="1">MSGQAAVDLAIAELRRGLEVGMANVEGQIALLHQIQGHHERRVDEHTRLLDELGERLAAAERDQVTRAQLDSRFRHTVALLGLIVTAASVLASTLLAMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XKV1</accession>
    <name>A0A1H5XKV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12105">
        <property type="protein sequence ID" value="SEG12105"/>
        <property type="gene ID" value="SAMN04489712_103291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025242">
        <property type="entry name" value="DUF4193"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13834">
        <property type="entry name" value="DUF4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG12105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="10968" checksum="EAA483C2D839BAF7" modified="2017-01-18" version="1">MATDYDSPRKTDDDLSEDSLQELQARRADKAASIIDEDLDAGEVAELPGADLSNEELTFRVVPRQADEFTCSRCFLVHHRSQLAEERKGQPICRECAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XKZ1</accession>
    <name>A0A1H5XKZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12017">
        <property type="protein sequence ID" value="SEG12017"/>
        <property type="gene ID" value="SAMN04489712_103288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025329">
        <property type="entry name" value="DUF4235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14019">
        <property type="entry name" value="DUF4235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG12017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="95" mass="9828" checksum="BF63CBF89D49B3EB" modified="2017-01-18" version="1">MADKGDIGWRVLAGGAALASGFAARRAITYAWKKTTGKEPPTNPESPDVALGEALGWAVVMGVGMEVARLLATRAAARRYAKSNGRLPAAFGLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XR23</accession>
    <name>A0A1H5XR23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation-transporting ATPase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_103367</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14112">
        <property type="protein sequence ID" value="SEG14112"/>
        <property type="gene ID" value="SAMN04489712_103367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cation_ATPase_N" evidence="10">
        <location>
            <begin position="622"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG14112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1494" mass="155248" checksum="3628406E702EDCF2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XVA8</accession>
    <name>A0A1H5XVA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxygen-independent coproporphyrinogen-3 oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15320">
        <property type="protein sequence ID" value="SEG15320"/>
        <property type="gene ID" value="SAMN04489712_103413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="39"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG15320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="432" mass="47446" checksum="37A6E0E65CCA768A" modified="2017-01-18" version="1">MTVADTAVSPYQGYVYAYPHKTAYRPLSPRPALREVWAGEDRGSLFLYLHVPFCEMRCGFCNLFTRTGASEDLTTAYLDALERQARAVHGALGEASFATAAIGGGTPTYLTAAELERLCDIAGRLADLTAIPLAVETSPATATADRLAVLAERGATRVSIGVQSFVDAEARAAVRPQKRAEVEAALDRIRAAGFPTLNIDLIYGIDGQTPRSWLSSLDTALLWEPEELYLYPLYVRPLTGLGRRAGDWDDQRMRLYQIGRDHLLAHGYEQVSMRMFRRRGHGDAGTAYCCQTDGMVGLGAGARSYTTGLHYSFDYAVGAGQVRGIIDDYLREPDFDVAHVGFTLDSEDRRRRHLIQSLLQAAGLDRAEYARRFGADALTDFPELSGHIERGWLDALPDALRLTPAGLAHSDTIGPSLFSARVQTLMDSYEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XVS8</accession>
    <name>A0A1H5XVS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15500">
        <property type="protein sequence ID" value="SEG15500"/>
        <property type="gene ID" value="SAMN04489712_103420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG15500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="21231" checksum="532B39CE6C603DCF" modified="2017-01-18" version="1">MIRVLLADDHLLIREALVLLLETEDGIEVVADVGRGDEAVERVRTLRPDVAVLDIDMPGMDGLAAAERLSREAPGCRLIIVTAHGRPGNLRRAMAAGVRGFLGKDAPGAQLATVIRQVAGGARYIDPQLAADALAAEECPLTPRELDALRAAADGAPISRIARGMGLSEGTVRNYLSAAVTKLGADNRHAAVRAARDHGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y006</accession>
    <name>A0A1H5Y006_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16866">
        <property type="protein sequence ID" value="SEG16866"/>
        <property type="gene ID" value="SAMN04489712_103475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290026" evidence="1">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG16866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="10727" checksum="41E13FF4D5A07201" modified="2017-01-18" version="1">MRLTRRGKAAVVIAMTGLMLGAFWLGTERGSHAAETPGSAPRQEVRTVAVGRDDVLWETAVRARPHTDPRLTVRRIAQLNGLPGSVVQPGRRLRPPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YIX6</accession>
    <name>A0A1H5YIX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23326">
        <property type="protein sequence ID" value="SEG23326"/>
        <property type="gene ID" value="SAMN04489712_1048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="26460" checksum="9353EA14CAD5ABF7" modified="2017-01-18" version="1">MVLLVLNAVASGLPPAYTVLRWIGLPWDRHYAVVLGAAMAVMALTFGLCLERAARLGTTPFLGGWGAAMVALAVGHMVTIAPYLNGLSVPVQLVGAAAVGALEGLLFGWVAGMVVKWAVVLSSAPETGSAARPDRPAQRALTPFLLITGVLLVAPVILGAVSWVMLSPDAAIPEDCGATVCVAESDAIMVPLVLAGAALVPLWAIAAFALGMRRLDHRFRQRGPVGQALAALSIAGSMALPMYLLTMFGGLFTPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YKK9</accession>
    <name>A0A1H5YKK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ClpX C4-type zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23916">
        <property type="protein sequence ID" value="SEG23916"/>
        <property type="gene ID" value="SAMN04489712_10435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG23916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="13308" checksum="B0CEA08E87C1DB66" modified="2017-01-18" version="1">MTSPDTLTELIRCSFCGKPDTEVAKLVAGAGVHICDECVALAASIIEGSPAKPAGPRAPVWQALTDEEMLSHIPRVAAHIDQAEADLRSWVLELRRRGVTWSRIGAALGITRQSAWERFSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YP23</accession>
    <name>A0A1H5YP23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25754">
        <property type="protein sequence ID" value="SEG25754"/>
        <property type="gene ID" value="SAMN04489712_104106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG25754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="33323" checksum="A4FF54585F263AE0" modified="2017-01-18" version="1">MATQETFFENARRRGVSADAIKTLRKWYRPCLSLETHGQGREIGHIGGLPMLPADATWDRHSLILTLDCAALPRKYLEVGFPEDGRLLLFGDNDVDGRGSVRYVPAGAETSERAAPQDEFDVLERRPLYASVSWSRKSPPHWVWGSEYADWLEADGLLGPGAEGLQACEEYHERCDGIPPDGRLGNIQVGGFANIAETPDHWSMAEHELRDRGVLPPDEAPDSEQPYPGDEERQALFRKYYAELAAEADQWVLLAQVLTQEAFDYSDGSMIWYIRQDDLASRRFDRAVSFCVYALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZD6</accession>
    <name>A0A1H5YZD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">A/G-specific DNA-adenine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_104237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28765">
        <property type="protein sequence ID" value="SEG28765"/>
        <property type="gene ID" value="SAMN04489712_104237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="7">
        <location>
            <begin position="44"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG28765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="32244" checksum="D75847DC690CF17B" modified="2017-01-18" version="1">MTAAPPNAARYTEPILGWYDEHARDLPWRAPGATPWAILVSEIMLQQTPVARVLPVWQQWMERWPTPAALAAEPSGEAVRAWGRLGYPRRALRLHACAVAITEQHGGQVPSSYDVLRALPGIGAYTAAAVASFAYRQRHAVLDTNVRRVLARLLTGVEYPPKSQTAAEVALAESLLPHDPPTAARWAVAVMELGALVCTARTPRCVDCPVLSSCAWHRAGRPAYDGPPRRGQTYAGTDRQCRGRLLAVLRHADGPVDKPALDVVWSDPVQRERALDGLIADGLVDPLDDGRYALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z1L5</accession>
    <name>A0A1H5Z1L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_104298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30178">
        <property type="protein sequence ID" value="SEG30178"/>
        <property type="gene ID" value="SAMN04489712_104298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="74"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="140"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG30178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="636" mass="67290" checksum="71BD092300515641" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZGF4</accession>
    <name>A0A1H5ZGF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35160">
        <property type="protein sequence ID" value="SEG35160"/>
        <property type="gene ID" value="SAMN04489712_104534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG35160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="881" mass="95710" checksum="6D1C59EACFD4978A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZI55</accession>
    <name>A0A1H5ZI55_9ACTN</name>
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        <submittedName>
            <fullName evidence="13">D-alanyl-D-alanine carboxypeptidase (Penicillin-binding protein 5/6)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_104541</name>
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        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">DSM 43163</strain>
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        <property type="gene ID" value="SAMN04489712_104541"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
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    </dbReference>
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        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="311"/>
        </location>
    </feature>
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        <location>
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            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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        </location>
    </feature>
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        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
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        <location>
            <position position="101"/>
        </location>
    </feature>
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            <position position="104"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <position position="281"/>
        </location>
        <ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG35327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="449" mass="46467" checksum="F2B42DB9F7509B78" modified="2017-01-18" version="1">MEHIRRAATALTVPLIAAPLVGQPAVALAAPAARRPAAVRTVPGQDPVGGPRLGERGVVVAAAPGVKAPPKINAGSYLIADAGTGQVLAAKNPHGHFLPASALKMLTAVALIPKLDPDATVRPTQETCDVEGTKVGMTPRLTYKVSDLFHALLMVSGNDAALGLAQAAGGLRPTLDTMNAEARRLRAGDTLAGSPNGLDKDLGLSVRTQHTSAYDLALIMRQGLKMPALRTYIGKNDHFWPAPPTKEERKKGKKTGGYPIYSHIRLLPGQRYAYRGMIGGKNGFTLAAGQTFVGAAQRDGRTIIVTLMNGENLWPDTTELLDWGFAYAGKASPVGVLVDPVDTTKPTPKPRGTGLLPTGPLPGGSSGGDWVVLGGAAGAAVLVAGGLFLLLRRRRQAGAGPAPQYGPAQTTPTQTGPAQSGPPPYLHGGPGGRAPDDDRPQGSPDEARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZWX9</accession>
    <name>A0A1H5ZWX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40275">
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        <property type="gene ID" value="SAMN04489712_10525"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291996" evidence="1">
        <location>
            <begin position="31"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="58"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG40275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="15165" checksum="CD830F18516D86B6" modified="2017-01-18" version="1">MDGIRRMPLLLAVAVTAVPLTMVPAVPAIAAATPGSGVTSRTIAQTTVDGRDYVLREITIWPGGSTGWHYHDGTLYALVKQGTLTRTLADCATVTHPRGSVVVEQSGPGNVHIGRNLGSTAVVLEALYVNPAGSPLAQDAPSPGCGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1F9</accession>
    <name>A0A1H6A1F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin-binding Protein dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_105105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MecA_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
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        <location>
            <begin position="169"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="267"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG41885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="547" mass="56996" checksum="365F2DD8F21E9F42" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2W5</accession>
    <name>A0A1H6A2W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43068">
        <property type="protein sequence ID" value="SEG43068"/>
        <property type="gene ID" value="SAMN04489712_105176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG43068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="16306" checksum="CE9160BCCEEEA1BC" modified="2017-01-18" version="1">MSDTGRAIEVLLVEDDPGDVLLTREAFEDNKVGNNLNVVSDGEEAMAYLRREGAYADAPRPDLILLDLNLPRKDGREVLGEVKADPQLRSIPVVVLTTSEADEDILRSYHLHANAYVTKPVDFERFIEVVRQIDDFFVTVVKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A8F1</accession>
    <name>A0A1H6A8F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45033">
        <property type="protein sequence ID" value="SEG45033"/>
        <property type="gene ID" value="SAMN04489712_105283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG45033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="233" mass="23663" checksum="EB89A3F68400AB57" modified="2017-01-18" version="1">MAVAFVAATANAVNSTTLPLTWPAVSSGHVALLGWSGLSTAVWTPPAGWTLLDAVTADSGNHASRVYWRPCDGSESGTITLTHDTLNKQSAVLIVWSGVDTATPIDAYAVRDENTAGTSHASPSASATMAGVVAVAMVSERVTDSTPSYTAPAGYTIRAQPTPIGLGGSVSLAMADLLTGTGGATTVTPGAWTGTVSTANVLTWTILLRPLVVVAGASPVPSAARRLRPLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9Q0</accession>
    <name>A0A1H6A9Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44777">
        <property type="protein sequence ID" value="SEG44777"/>
        <property type="gene ID" value="SAMN04489712_105270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="59" mass="5769" checksum="636E422712CA865E" modified="2017-01-18" version="1">MRELVTTLLDAVGLGLVAAGAAAAVFPLVGWAGLALAGGVVLAGSWWAARPARPAGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AAE5</accession>
    <name>A0A1H6AAE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45678">
        <property type="protein sequence ID" value="SEG45678"/>
        <property type="gene ID" value="SAMN04489712_105317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG45678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="30587" checksum="29C88A2EF6F78C91" modified="2017-01-18" version="1">MTVRRERLTAAIRRSGMYGALRESIYRMYERRVEASLPTDNVPRHVGVILDGNRRWARSMGLADVNTGHQRGADKITELLHWCTEAGVELVTLWMLSTDNLNRPAKELDPLLDIIENTVAKLAADGWHVKAVGAMDLLPDSTARVLKQAEETTSDRPGLIVNVAVGYGGRREIADAVRSLLLEQAGKGTSIEELAEVLEVEHIAEHLYTRGQPDPDLVIRTSGEQRLSGFLLWQSAHSEFHFCEVHWPDFRRVDFLRALRSYAARHRRFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADR2</accession>
    <name>A0A1H6ADR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein involved in the export of O-antigen and teichoic acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_105388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46873">
        <property type="protein sequence ID" value="SEG46873"/>
        <property type="gene ID" value="SAMN04489712_105388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="8">
        <location>
            <begin position="355"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG46873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="527" mass="53750" checksum="BC72745D42AC9202" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AX33</accession>
    <name>A0A1H6AX33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53209">
        <property type="protein sequence ID" value="SEG53209"/>
        <property type="gene ID" value="SAMN04489712_10679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="652" mass="71829" checksum="2E3CF977A2F10418" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZE1</accession>
    <name>A0A1H6AZE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_106110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53700">
        <property type="protein sequence ID" value="SEG53700"/>
        <property type="gene ID" value="SAMN04489712_106110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="1261"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG53700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1346" mass="144862" checksum="923172F1F2749623" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B176</accession>
    <name>A0A1H6B176_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54588">
        <property type="protein sequence ID" value="SEG54588"/>
        <property type="gene ID" value="SAMN04489712_106166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG54588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="21880" checksum="237226675D184C6A" modified="2017-01-18" version="1">MTGDLDADYAAAGFGGSLPFGSRPAVVAIDIARAYLDPGSPLYAGVEDAVAAAARLVSAARDRGVPVLFTRVEYGPDGRDGGLFYRKVAALRCFDAGNPLGDFPDEPRPRPDETVVVKQYASAFFGTSLAATLTATRVDTLLLCGLSTSGCVRASAVDAVQHGFVPIVVRDACGDRDPRPHEANLFDLQAKYAEVVSLEAALAYLSGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BDD9</accession>
    <name>A0A1H6BDD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein, MTH1187 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58843">
        <property type="protein sequence ID" value="SEG58843"/>
        <property type="gene ID" value="SAMN04489712_10726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG58843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="10372" checksum="E94F62C6801333E2" modified="2017-01-18" version="1">MLVAFSVTPLGAGEDVGELVAEAVRVVRASGLPHRTDAMFTTVEGEWDEVMAVVKAATDAVAARAPRVSLVLKADLRPGVTDAMTKKVESVERHLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BFR9</accession>
    <name>A0A1H6BFR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRSP domain C terminus to PRTase_2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59631">
        <property type="protein sequence ID" value="SEG59631"/>
        <property type="gene ID" value="SAMN04489712_10781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041688">
        <property type="entry name" value="PRTase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022537">
        <property type="entry name" value="TRSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011214">
        <property type="entry name" value="UCP020967"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15609">
        <property type="entry name" value="PRTase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12500">
        <property type="entry name" value="TRSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020967">
        <property type="entry name" value="UCP020967"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRTase_2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="TRSP" evidence="2">
        <location>
            <begin position="371"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG59631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="535" mass="55424" checksum="A429F2DC9B67A9B4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BHL0</accession>
    <name>A0A1H6BHL0_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107115</name>
    </gene>
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        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60190">
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        <property type="gene ID" value="SAMN04489712_107115"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293772" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="11367" checksum="2C6DBE8D5D5F0973" modified="2017-01-18" version="1">MRLLVLVAAVLLVALAVMLVVSAFTRERGGGEALEATARWEAHTVSADGVTTVVVRKVAQTPQGPVEFGRQSIASIPDGDPEWESRYHEAMAQARSRVAALQIEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BIK3</accession>
    <name>A0A1H6BIK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain-containing protein, G-beta repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60422">
        <property type="protein sequence ID" value="SEG60422"/>
        <property type="gene ID" value="SAMN04489712_107130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037783">
        <property type="entry name" value="Taf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="PTHR19879"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="612"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="688"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG60422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="797" mass="85344" checksum="EEA7FB8A31E0A440" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BME2</accession>
    <name>A0A1H6BME2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_107225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61577">
        <property type="protein sequence ID" value="SEG61577"/>
        <property type="gene ID" value="SAMN04489712_107225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="25"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG61577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="553" mass="56846" checksum="373AEBC66FDCA3BD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYC2</accession>
    <name>A0A1H6BYC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_108125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65688">
        <property type="protein sequence ID" value="SEG65688"/>
        <property type="gene ID" value="SAMN04489712_108125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
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        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="189"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG65688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="42271" checksum="99F9DB9378B41D6E" modified="2017-01-18" version="1">MKALTWHGKRDVRVEEVPDPVIKEPTDAIVRITSTGICGSDLHLYEVLGPFIGEGDVLGHEPMGIVEEVGAEVSHIRPGDRVVIPFNISCGHCHTCAQQLYAQCETTQVRDQGMGAALLGYTKLYGEVPGGQAEYLRVPQAQFGPIKVPEGPPDERFVYLSDVLPTAWQAVQWADIPDGGSVTVFGLGPIGQMAARVARHLGYRVIAVDPVPERIGMARRHGIEVLDAGRVDVAAEAIRDMTKGRGTDSVIDAVGMEAHGSPAAKLAQTVTGLIPDRAAAGLMSRAGVDRLAALNQAIDTVRRGGTISVVGVYGGMADPLPMLRMFDKGITLRMGQAHVKRWIEDLMPLVTDDADPLGTEDLATHRLPLEQAPHGYEIFQKKRDGAIKVLLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1E9</accession>
    <name>A0A1H6C1E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding universal stress protein, UspA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66475">
        <property type="protein sequence ID" value="SEG66475"/>
        <property type="gene ID" value="SAMN04489712_108196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG66475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="15830" checksum="B16798847C16624E" modified="2017-01-18" version="1">MASYRTILVGTDGSDSSFRAVESAARLSADTGATLLLASAYHPMSERERLSAADRLGDLAYKVQGSTPAEDALRAARERAVAAGAKDIDEVAVEGDAVDVLTKVARDRGADLLVVGNRGLNSLAGRILGSVPANLSHRSPCDILIVHTTDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C224</accession>
    <name>A0A1H6C224_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67011">
        <property type="protein sequence ID" value="SEG67011"/>
        <property type="gene ID" value="SAMN04489712_108246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035223">
        <property type="entry name" value="DUF5335"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17269">
        <property type="entry name" value="DUF5335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG67011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="121" mass="13194" checksum="75B8C88E57BE8DF2" modified="2017-01-18" version="1">MTETMTVERDGWVGFFDTLTADHQGHTVAIELVDSEYGDQYETEGLPFNYASYDPRDDVVVVGVGGNSARFPVVLRHMINHPAEVDVTASRPAEADVRVIDGDGTATMLCLRPRPALPESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C245</accession>
    <name>A0A1H6C245_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PrcA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prcA</name>
        <name evidence="4" type="ORF">SAMN04489712_108218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66725">
        <property type="protein sequence ID" value="SEG66725"/>
        <property type="gene ID" value="SAMN04489712_108218"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_B">
        <property type="entry name" value="Proteasome_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022296">
        <property type="entry name" value="Proteasome_asu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF69">
        <property type="entry name" value="PTHR11599:SF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03691">
        <property type="entry name" value="20S_bact_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG66725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="25774" checksum="BACC8026E0566637" modified="2017-01-18" version="1">MSMPFYVSPEQAMKDKADYARKGIARGRSVVVLQYDEGILFVADNPSRALHKISEIYDRIAYAAVGKYNEFETLRLAGVRYADINGYQYDRQDVTARGLANAYAQTLGNIFTETAKPYEVELVVAEVGEDAESDQIYRLTFDGSVRDEHGYVAMGGQVEAVEQALKERYQEGMSLSAALHAGVQSLEAQEADRHLEAKALEVAVLDRRREHRLFRRLSAARIQELLADSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8J7</accession>
    <name>A0A1H6C8J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-sedoheptulose 7-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68696">
        <property type="protein sequence ID" value="SEG68696"/>
        <property type="gene ID" value="SAMN04489712_10913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="38"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="21360" checksum="610A5F276F34FC8A" modified="2017-01-18" version="1">MERRSAADLVRDAFVRRTAPGRGLAEDAEAVARACHDMARRFHRGGRLLVFGEGSAAADAQHVAVEFVHPVLVGRRALPAVSLAGDAATLTAIAGSQGLDAVFSAQLRLLASPADIALGLSADGRCASVLRGLETAAELGALTVALVGGDGGDIARGGVVEHCLIARSADPCVVKEIHVTTYHLLWELVHVFFDQSGLLEPEAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCB9</accession>
    <name>A0A1H6CCB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase, sigma 29 subunit, SigE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_109189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70659">
        <property type="protein sequence ID" value="SEG70659"/>
        <property type="gene ID" value="SAMN04489712_109189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="109"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG70659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="180" mass="20706" checksum="44D65DE2670D8E1E" modified="2017-01-18" version="1">MAWTPPTWEEIVQEHSTRVFRLAYRLTGNRHDAEDLTQDVFIRVFRSLSSYTPGTFEGWLHRITTNLFLDRARRRQRIRFDALPDDAERLQGGEPSPAQLYDDQLLDADIQRALDDLAPEYRAAVVLCDIEGLTYEEIAATLGVKLGTVRSRIHRGRAQLRDALEHRRPLTTDELPAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CD94</accession>
    <name>A0A1H6CD94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70832">
        <property type="protein sequence ID" value="SEG70832"/>
        <property type="gene ID" value="SAMN04489712_109209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294716" evidence="3">
        <location>
            <begin position="37"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG70832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="23082" checksum="0B2AC3E95DDDAB34" modified="2017-01-18" version="1">MVLGARTRSSSAGRALACAVLGVALLLITPPVTALPRDLAISPARHTDRSAPGVTTYAVTVRPRAAMAEGVTLTLGAGPGRPAKRRSPGRDAEGVRIVPPPGWRPQSWAGHPRYCHPAHGAIMLHCALGNLDRPRTVHLTVRGPGAAAPPGLTAVAQSRTSRGLAMARLPAAPAARGVTEESPWAVMIAIVLAVEVALFWIVACVGLWRHRVTGDRDSADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CET9</accession>
    <name>A0A1H6CET9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71529">
        <property type="protein sequence ID" value="SEG71529"/>
        <property type="gene ID" value="SAMN04489712_109281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="120"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="30040" checksum="03BCEA4559B61798" modified="2017-01-18" version="1">MGAACPGPRGRHKVVIVTDPFAQVAALPGVPEAVADARTSVDRLLGHRILRRRSAEVSTESALRAARASAALEGVSVPLDELRRGAAAQGEAAVPADPIVQGALRVSAELGTLTDTWRRAPRQVLARLHVLAAADAVEAEELGRPRLEGQDAKDFLGLGERPAPEEVAVRLDSLSTLLTQQTKAPAIVVAAIVHGELLALRPFGWGDGIIARAAERLTLVDRGLDPKSLTAPEVGHAELGDEYVRTLRGYIGGTSEGVAAWIRHCAAAVTVAARDSLAICEAYLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CHY5</accession>
    <name>A0A1H6CHY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72528">
        <property type="protein sequence ID" value="SEG72528"/>
        <property type="gene ID" value="SAMN04489712_11010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG72528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="26382" checksum="229CED38E949F218" modified="2017-01-18" version="1">MSNAADVSVLRARGLRREYGKGEGLVRAVDGVDLDIGAGETVAVMGPSGCGKSTLLHLLGGLDRPSGGEVWLNGRRIDDLGEKALARMRRTDVGFVFQSFHLMEELTALENVELSALLAGRSPRAARRRAGDLLEQVGLADRARFLPSALSGGQRQRVAIARALSNEPLVVLADEPTGNLDSAAVLDVLQLFERLHESGQTLVIVTHDARIAATADRMISMRDGAFVDETRLSGGTTGQLGAFVGLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CI08</accession>
    <name>A0A1H6CI08_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72640">
        <property type="protein sequence ID" value="SEG72640"/>
        <property type="gene ID" value="SAMN04489712_11022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="PTHR31544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GGACT" evidence="3">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG72640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="16364" checksum="536EC4A763A34E1F" modified="2017-01-18" version="1">MDALAGDDRPPGPADPAGATRCEPDGLFVYGTLRFPEVLQALLGRVPELEPARAVGWRVKALPGVVYPGLVADPGGVADGLLMTGLSEAERRLLDAYEGESYEPRRMALDDGRRAWTYVWKGRTEPDDWNPARFAERDLPAYLDQWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIQ8</accession>
    <name>A0A1H6CIQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72812">
        <property type="protein sequence ID" value="SEG72812"/>
        <property type="gene ID" value="SAMN04489712_11037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG72812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="485" mass="53385" checksum="6A59E0E05FC2EC22" modified="2017-01-18" version="1">MPERTPVEEPDLTEPEALLWNAYLTGETVDLGAGRSDRTVRAEVIARLLLGAREPLPGHVPAVRLRGAHVTGRLDVSGGVIECELRLEHCVLDEMPDFSNAQTRQLRLSDCRMPGFDGGGLRADGYLSLSGSRINGSVRLPRAQLSGGLRMNRTKVISSGPEQWALFSGGLVVDAGAFLRHAEFTGGVRLVGARMNGGLFMEGTTLRNPGRRALDAQNILIEDAAELSHGFTAEGKVRLRNAQVHGTLSFDQAGPLRNPGAMCLHLSHMQVEELILTPSVPVEGIVSLAYSKIGVLLDNPDHWPERLRLQGLTYESLRGGGVTRRIDWVGRDIEGFRPQPYEQLAAWYRRDGNDHLARRALLYKQRARRRSLPRHSRAWGALLDVTVGYGYRPWLAAAWLGALLTAGTVVFGLIPPHPLKQPTERPDFHSFIYTLDLLVPFGAFGQREVWNPDGWTQWLAYGLIAAGWILATALIAGATRVLRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CK84</accession>
    <name>A0A1H6CK84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name evidence="2" type="ORF">SAMN04489712_110107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73411">
        <property type="protein sequence ID" value="SEG73411"/>
        <property type="gene ID" value="SAMN04489712_110107"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="24483" checksum="23443D9BADC94CCF" modified="2017-01-18" version="1">MNAARVGVITFPGSLDDRDAARAVRLAGAEAVSLWHADHDLRGVDAVILPGGFSYGDYLRAGAISRFAPLMEELVPAARAGLPVLGICNGFQVLCESHLLPGALLPNAGLHFVCRDQRLRIDNADTAWTAEYTEGQEVVIPVKNRDGRYVADERTLAELEDEGRVVARYLDLNPNGSLNDIAGICNEAGNVVGLMPHPEHAVESLTGPSTDGLGFFTSLVKAGLSRAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKW0</accession>
    <name>A0A1H6CKW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carbon starvation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_110125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73558">
        <property type="protein sequence ID" value="SEG73558"/>
        <property type="gene ID" value="SAMN04489712_110125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="10">
        <location>
            <begin position="51"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="11">
        <location>
            <begin position="483"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG73558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="733" mass="77826" checksum="6DA0CC35B9E970F7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM10</accession>
    <name>A0A1H6CM10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_110140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73675">
        <property type="protein sequence ID" value="SEG73675"/>
        <property type="gene ID" value="SAMN04489712_110140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG73675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="228" mass="24251" checksum="9B25F3A291B0D211" modified="2017-01-18" version="1">MTATVTTTGLALDGVTLEYGSGDTLVTALDEVTLTVEPGQFVAVVGPSGSGKSSLLAVAGALIHPTRGRVRIADVEVSGTKARDLAELRRTRIGYVFQSGNLPASLPVRDQLLLVPHLSGRITADARAYADELLEAVGLTAKAGRRPHELSGGERQRVGLARALMNRPAVLLADEPTAALDRRRAREIVALLAEQSHRRGAATVMVTHDTELLDSADRVVHMRDGRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CP88</accession>
    <name>A0A1H6CP88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_110207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74266">
        <property type="protein sequence ID" value="SEG74266"/>
        <property type="gene ID" value="SAMN04489712_110207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="115"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG74266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="322" mass="36059" checksum="7CFBC337190A7ECA" modified="2017-01-18" version="1">MTNLTATRPPATPVPDKRRAAPKRRPRTRFTSEHRTILSPHQLNSRWGRRIYWLVLVSTVLVFTAVFVFPLYWMVTGAMKTGEEFARIPPTYVPSRFSLDGYRQAWELMNLDRFLLNTLQYAFGAWAFALAFDVGAAYALSKLRPLFGNVILLAMLATLMIPPTVILLPAYLTIKDVPIVRLDLLNTPWAIWLPAVANGFNIFLLKRFFDAIPTELIEAAQLDGASPLRILRSIVLPVSRPILGVVSIFTVVNVWRDFAWPLLVLQDPEKMTISVGIASLRANMPQTTMTAALVIASIPTIVVFFLFQRHIMAGLTAGGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTH4</accession>
    <name>A0A1H6CTH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiaminase (Transcriptional activator TenA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76300">
        <property type="protein sequence ID" value="SEG76300"/>
        <property type="gene ID" value="SAMN04489712_111147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034641">
        <property type="term" value="P:cellular nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046483">
        <property type="term" value="P:heterocycle metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901360">
        <property type="term" value="P:organic cyclic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="1">
        <location>
            <begin position="31"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="24485" checksum="3DFAA79543456356" modified="2017-01-18" version="1">MVSQAICDVSRASCETSGMSVAAYLEELGRPLLDEQLGHPTVVGIAKGDLDERVFRSWLEQDYLFLLDYVRVFSRLAWQAPDGHLGDLVDLAYATFHEELSLHRSLAAEFGADLEGARKGPACAAYTGFLLESAASYGEGLAALYPCMWGYSTLGGILAADPPAEPRYRRWVDTYADPGFAALARRIAEMIDEAAPSLERAEQKFREGMRHELAFWSVPLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVF1</accession>
    <name>A0A1H6CVF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_111228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76944">
        <property type="protein sequence ID" value="SEG76944"/>
        <property type="gene ID" value="SAMN04489712_111228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="4">
        <location>
            <begin position="211"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG76944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="437" mass="47508" checksum="8BD0C45E1613D21B" modified="2017-01-18" version="1">MVATRAGAQARCRGARHATRRSAFYGNLRPQVYELIQSESVDPVRNPYAPGAGQRPPELAGRDRELRQFEVVLERVARGRPERSMIITGLRGVGKTVLLNTFRSMAIQRLWGTGKIEARPEQSIRRPVASALHMAIRELAPRHRAPERIEYFLGVLKAFAQAGEEAGGKGRARAHRWQPGIEVPAVRGRADSGDLEIDLTELFVDAASVATDLGVGIGLFVDEMQDVPADDVSALCAACHELSQIGGPLIVVGAGLPHLPAVLSASKSYSERLFRYARIDRLDRASADLALLAPAEREEVTFTPEALDALYEAADGYPYFVQAYAKVAWDIAPASPINAEDIEVAAPEAESELAVGFFGSRYERATPAERDYMRAMAMLGDDPVPTAAVAEELGRKPSSLSPARDGLIKKGLIYSAERGLVAFTVPHFGKFLRSQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CXL0</accession>
    <name>A0A1H6CXL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77235">
        <property type="protein sequence ID" value="SEG77235"/>
        <property type="gene ID" value="SAMN04489712_111268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG77235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="88" mass="9516" checksum="2C2243AF8EA97D3D" modified="2017-01-18" version="1">MRADVGFEAFRVASPQDGWYLPLQLSRRLIPHGTSNVDAFAVPLHYAAPGSADGIGLLPGELFGHRLEHHGRFMLRSALAVGPEDPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3M3</accession>
    <name>A0A1H6D3M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator, OmpR family, contains REC and winged-helix (WHTH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79246">
        <property type="protein sequence ID" value="SEG79246"/>
        <property type="gene ID" value="SAMN04489712_112188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG79246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="237" mass="25772" checksum="668BBBD75F210528" modified="2017-01-18" version="1">MSSLLLLTNALEPSDEVLPALGLLLHSTRVAPAEASALIDAPPADVVLVDARRDLVQAKSLCRLLRTTGLDCPLLAVVTEGGLAALSPEWGLDDVLLQSAGPAEVEARLRLAVGRVAAGEADDVPGEIRSGDLTIDEATYTARLRGRVLDLTFKEFELLKYLAQHPGRVFTRAQLLQEVWGYDYFGGTRTVDVHVRRLRAKLGAEYESLIGTVRNVGYRFVPDHRPGEAEAREPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4Z2</accession>
    <name>A0A1H6D4Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prenyltransferase and squalene oxidase repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80124">
        <property type="protein sequence ID" value="SEG80124"/>
        <property type="gene ID" value="SAMN04489712_11319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="SQHop_cyclase_C" evidence="3">
        <location>
            <begin position="156"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG80124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="595" mass="64813" checksum="601FF63530834296" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D666</accession>
    <name>A0A1H6D666_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80468">
        <property type="protein sequence ID" value="SEG80468"/>
        <property type="gene ID" value="SAMN04489712_11387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="112" mass="11739" checksum="5576806621083B51" modified="2017-01-18" version="1">MIGMEIIPVDRCAGPDGGAHYVEHLRVEALSVGTYSIPAGGTDPQRPHTEDEVYVVIGGRGAFTGGDRTVPVGPGTVLYVPKHEEHRFHDVTEDLVICVMFAPAEGSAAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6U5</accession>
    <name>A0A1H6D6U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80678">
        <property type="protein sequence ID" value="SEG80678"/>
        <property type="gene ID" value="SAMN04489712_113129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="28010" checksum="DADB51E205E35623" modified="2017-01-18" version="1">MTGTGRSHEIMFVTPAVPHRFPVFPRSIGGAGRPVRTAVSTALRRTHDILHWRPGNSACCSPWPLPRSRPVTSGIGGPAGRPRPPDRPHLGRPHLGRPHLGRPHAGRHTLPSRLGRPRLGRPYLGRPYLGRPYLGRPYLGRPYLGRPHLAVRDQRRGTSGVPPRGRARGRRFGILRCPDPGRRLVRWPGSGKDGAGRVATRLGRPSEKRLGELPALPAFHGGEDVRTAEEDSDRDRPSRRQRRRSPPAAPPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9W6</accession>
    <name>A0A1H6D9W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Right handed beta helix region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81326">
        <property type="protein sequence ID" value="SEG81326"/>
        <property type="gene ID" value="SAMN04489712_11426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="332"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="576" mass="61376" checksum="B78A8DFEB5995815" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCC6</accession>
    <name>A0A1H6DCC6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">SAMN04489712_11511</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82335">
        <property type="protein sequence ID" value="SEG82335"/>
        <property type="gene ID" value="SAMN04489712_11511"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="40"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG82335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="36962" checksum="08528BCABBE2BC1C" modified="2017-01-18" version="1">MSKPTLAVVGATGAVGTVMLDLLSTREDVYGEIRLVASPRSAGKKLTVRGEQVEVVALAPEVFDGVDVAMFDTPDEVSKQWAPIAAERGAVAVDNSGAFRMDPDVPLVVPEVNAEAARNRPRGIISNPNCTTLSMIVAMGALHGQYGLRELVVASYQAASGAGQAGIDTLYDQLEKVGGNRGLGERAGDVRRVVGEDLGPFPAPLAMNVVPWAGSLKDDGWTSEELKVRNESRKILGLPDLRVSATCVRVPVVTTHSLAVHAVFDRPVDQREAQAVLAGSPGVVLVDDPEAGEFPTPADVVGTDPTWVGRVRRSLDDPKALDLFLCGDNLRKGAALNTAQIAELVAAEFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCS0</accession>
    <name>A0A1H6DCS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_115105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82912">
        <property type="protein sequence ID" value="SEG82912"/>
        <property type="gene ID" value="SAMN04489712_115105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7658" checksum="7B45B774CC5F1D99" modified="2017-01-18" version="1">MSDDQGVRQSTDGTIVVTGHYRGTARATGRAYEAEFVHLWRVTDGRISWLHQYTDTVRWHQALAPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DES7</accession>
    <name>A0A1H6DES7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83721">
        <property type="protein sequence ID" value="SEG83721"/>
        <property type="gene ID" value="SAMN04489712_11655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG83721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="25280" checksum="6D39FC39E8313FD3" modified="2017-01-18" version="1">MTKPAASSARPAEEAPRPRRRLTAEARKSSILAAARRAFTETGDMNGTTIKVIAEHSGISEGVIYRHFESKDQLFYEAVVEPLKQAVDDLVAATAAVDREQPLTPERQLRTMTGLYRQLISTLEEILPLLGLVLFGDPQVARRFYQEDFTVAMDRLAEAWREVEDRYGYPFESPDISARAVMGIALVLALESHHGKGFDRHRAVTLISEGTVKGFFPPLEAARRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DI18</accession>
    <name>A0A1H6DI18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemerythrin HHE cation binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hemerythrin family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84844">
        <property type="protein sequence ID" value="SEG84844"/>
        <property type="gene ID" value="SAMN04489712_11778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035938">
        <property type="entry name" value="Hemerythrin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47188">
        <property type="entry name" value="SSF47188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="15"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG84844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="158" mass="17255" checksum="1CCA6A7E006E8574" modified="2017-01-18" version="1">MSEGDQSRLIAWNRELAAAHQRLRQALRLARQALDAGHAEDATSAGADLLLYCHGFCAALSGHHVSEDAALFPELAARHPALRPTIAKLEQDHQMIASLLAQFQQALTSNAPPDTLASHLDGLAAIMESHFRYEERQLLDILSTLELHADPRTVLGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJ27</accession>
    <name>A0A1H6DJ27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84616">
        <property type="protein sequence ID" value="SEG84616"/>
        <property type="gene ID" value="SAMN04489712_11735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="297" mass="32390" checksum="446BD54B4FF1C4EA" modified="2017-01-18" version="1">MTRTVLITGATGTVSTALMNALAGAEVNLRALVRDTSQADDLRARGAEVFAGDLDDARSLPPAFEDVQDVWLLTPNGPRAPENNMNAVWAARQAGAERIVRLSAVGAAHHAPTRSGRLHALSDRETERCGMRWTILRPHWFMQNLLNEAGDISATGTFSLNMASARIAMIDARDIAECAARILLDDPDRHHGQTYTLTGPRSLTFHEAADQLSLTLGRPVTYLPASDDAQRKTLLSHGVPPWIIDMLQEYAQAYASGWGDFTTDTAADLLGRPPRDIADFARDHAADFARDHAADFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJ97</accession>
    <name>A0A1H6DJ97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84775">
        <property type="protein sequence ID" value="SEG84775"/>
        <property type="gene ID" value="SAMN04489712_11766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG84775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="14534" checksum="5853FEBD34F0980C" modified="2017-01-18" version="1">MRAGDADRDATIQALGDALAEGRLDPAEHDSRLTRAATATTFGQLAALTADLPPSPSAATGGQTTTDPAHRQDDRRAWLKEVQYWLGGALVMNLIWAAQSLKDHQWASYWPAVPLGIWAAILLTYLIWPQDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DN10</accession>
    <name>A0A1H6DN10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MLTR_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86649">
        <property type="protein sequence ID" value="SEG86649"/>
        <property type="gene ID" value="SAMN04489712_119136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="112" mass="12355" checksum="BD177047FC9F2F30" modified="2017-01-18" version="1">MAPNVADTAAHPNGEITDGFTLTIEALQAASADFRRLWAEHEVAVRRVDRKTILHPRVGRLTMDCETLVTPDQGQQLLVLTPADAEARERLELLRVLGIEEFPTGATDTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNV1</accession>
    <name>A0A1H6DNV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfonate transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86215">
        <property type="protein sequence ID" value="SEG86215"/>
        <property type="gene ID" value="SAMN04489712_11922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG86215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="32192" checksum="1DE3042F4C0B51DC" modified="2017-01-18" version="1">MTVQMDRSVSRNEDSWVEHRPDSKQRSTAHQARRDGVLRLVLGLVLPVGMLVAWEISARSGWIDARFFSQPSAVAAKAWEDMQSGLLWSELKITIVRLLTGYVVGSLAGILIGLLMSQVKVLRWMLEPMIRALYVIPKLALLPLFLLLFGLGEVPKLIFIALGTFYIVAFTTLSAAMMIPTAFHEVARSYGLSSGQRFRWVIVPAITPQIVSSLKLASGISMLLVIAVEFVNAHEGLGYYTWHAWQIFVPDRMYVGVVTISIVGVLFSGLVGLLGSRVARWADSEYAQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP43</accession>
    <name>A0A1H6DP43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="7">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="7">PII uridylyltransferase</shortName>
                <shortName evidence="7">UTase</shortName>
                <ecNumber evidence="7">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="7">UR</shortName>
                <ecNumber evidence="7">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnD</name>
        <name evidence="11" type="ORF">SAMN04489712_12062</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GlnD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="7"/>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87069">
        <property type="protein sequence ID" value="SEG87069"/>
        <property type="gene ID" value="SAMN04489712_12062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="10">
        <location>
            <begin position="455"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="635"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="744"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG87069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="814" mass="86219" checksum="8C7B7CC0D8D4F10B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPX1</accession>
    <name>A0A1H6DPX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_120102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87280">
        <property type="protein sequence ID" value="SEG87280"/>
        <property type="gene ID" value="SAMN04489712_120102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13933" checksum="13898F8B9D300D69" modified="2017-01-18" version="1">MGDTLDVVFGGTSVNSSRISPGSPVWAGPRWEDPALTRLALRLRDAHRMVAPLPAEPRRRLIRHLLTITDLAKRDCELAARRLEAFLVDLAERVNTDGDESDTSGSFSSSEGPQSDEIACDTASIACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DS49</accession>
    <name>A0A1H6DS49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88099">
        <property type="protein sequence ID" value="SEG88099"/>
        <property type="gene ID" value="SAMN04489712_12176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG88099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="7110" checksum="EB34E22D74DBDB12" modified="2017-01-18" version="1">MKVRVDSERCQGHTLCAMIAPEVFRLREIDGHSEVIDEEVPAGQETQVIEAVNSCPERAISTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTF8</accession>
    <name>A0A1H6DTF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family mycofactocin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88530">
        <property type="protein sequence ID" value="SEG88530"/>
        <property type="gene ID" value="SAMN04489712_12224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="30313" checksum="D6BF06FC32F8EFD3" modified="2017-01-18" version="1">MGRVQDKVVFITGAARGQGRAHAVRLAEEGADIIGVDLCANIATNDYPLATREDLDETVRQVEKLGRRMFAAQADVREPAVLAGAVSQGVAELGRLDAVVAQAGICPLGSQDAQAFLDAVAVDFNGVVHAVQAALPHLPDGASIVATGSVAGLLPGATDNPANGFGGMGYSWAKRAVASFVHDLAVTLAPRRIRANAVHPANCNTDMLNSDVMYRAFRPDLENPTREDALVTFPAMQAMPVGFVEPEDIADMVLFLVSDESRFVTGMQMRVDAGSYVKNRPQQPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVI9</accession>
    <name>A0A1H6DVI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88605">
        <property type="protein sequence ID" value="SEG88605"/>
        <property type="gene ID" value="SAMN04489712_12241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="415"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="502" mass="54054" checksum="F6003EE10AB6BD13" modified="2017-01-18" version="1">MKTVDADRDRPLSRRLRQMLSLDPDATALTFEDRTYPYAYHLEAIEDLDHLLGDARIRRVGIVLHNRPALVAALIAALATGREVVPLSPFHGDVGLAEDIASLTPQAVIADPEDWARSGVTEAVAGVRAVAVRTGEDRALRAQPADWTADPKPAGPSDVAVLMLTSGTTGRPKRVELTYSRLTAAFTAGGHGEALTGEPRLRPGTSILWGSLVHIGGLYFAVGAVLEGRAVALMERFDVAEWAALVAEHRPRMVGLPPAAMRMVMDAEVPREVFDGVRAVLSGTAPLDPDDADRFEARYGVPVLTNYGATEFAGAIAGWDLRLRREWGTAKRGSVGRAHPGVELRVVDPETTAVLPCGEIGVLEARGGQLPGAEDGRWTRTTDLASLDEDGFLFIHGRVDEAINRGGFKIVPSVIEDALRGHPAVRDASAVGVPDSRLGEVPVAAVTLKRPADPGTLRDWLADRLARYHLPAEIKIVDELPRTPSLKVSRPAVRALFTEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWM5</accession>
    <name>A0A1H6DWM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89750">
        <property type="protein sequence ID" value="SEG89750"/>
        <property type="gene ID" value="SAMN04489712_12451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="174" mass="19271" checksum="4578AFA3FB5B259F" modified="2017-01-18" version="1">MSFMTQLKDEGGSPWLGDVRVRPYGITDGPRLRRMSGRLSTHSLYSRFFAGTPHIPDTYVRHLDRLDHWDREALVALVDDDIVGIAEYVRAPADPHRAELAVLVTDPWQRHGVGRLLVGCLALTAARRGITAFDAGVLPGNRPALSAIRTAWPLVRPWHEDGSAHFRLPLGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYJ9</accession>
    <name>A0A1H6DYJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90422">
        <property type="protein sequence ID" value="SEG90422"/>
        <property type="gene ID" value="SAMN04489712_12632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="340"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="750" mass="79868" checksum="CC6D29631C84EC71" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1A3</accession>
    <name>A0A1H6E1A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA carboxylase epsilon subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90776">
        <property type="protein sequence ID" value="SEG90776"/>
        <property type="gene ID" value="SAMN04489712_12735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="74" mass="7674" checksum="E5A9A0EE189B28A0" modified="2017-01-18" version="1">MSAEGRPFLQVVRGDATPEEIAALVAVLSARAAAASAAAGGGTRRTSAWADRSRMVRTPLPHGPGAWRHSALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4L5</accession>
    <name>A0A1H6E4L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92173">
        <property type="protein sequence ID" value="SEG92173"/>
        <property type="gene ID" value="SAMN04489712_13247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="213"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="418" mass="47321" checksum="50E2E71CA98F49FF" modified="2017-01-18" version="1">MTATPPTDTKTTRKTRGRGRANGEGSVFPYRNGYAAYVWVTTPDGKRTRKWAYGKTREETHDKWLKLHDAARKGPVATKSPTLEAYLQRWLADVVQPELAPATAANYEMFVRLYIVPTLGRKRLDKLTVADVRTWLNKLRETCQCCAQGKDARREEKARRCCAVGKCCKQLASERTCRDAWTTLRAALGNAVREEILPRNAAALLRVSKPRKRRVKPWTVDEARKFLESARKRRDPMYAAYVLILALGLRRGEVLGLRWADVDLDAEEVRVGWQLQRVKGRLLHRETKTEASDAALPLVGICTTALRERQKEQDTAREAAAEWTDTGFVFTTRTGQPVEPRNFNRSFATACDRAGVRRVPVHVTRKTCASLLVALDIHPRVVMQILRHSQIAVTMDIYSEVSTAATRKALRKLGKQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5G3</accession>
    <name>A0A1H6E5G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92483">
        <property type="protein sequence ID" value="SEG92483"/>
        <property type="gene ID" value="SAMN04489712_13411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="36086" checksum="1D0D16AFC5A07243" modified="2017-01-18" version="1">MPSLTLRGLVALSVAVLGMGMCGCTEKGEPHAGPGGVAKAGTTRPEPSRTVGRRVVPRVPKGVRAGYMVFDRETGKVTAQHNAHGTVRSASVVKILIALDHLERSGGRAVPAGDLALLRGMLRSSDDGAATALWNRGGRGAIVTRMVRRLRLADTAPPPASRPGYWGYTAISAYDVVKTYRYLLEKAPERTRRFVLGELRRATRCGKDGFDQYFGIPRALPRPWAVKQGWSGFGTVPDEPCGGATANGLRLRPMAGAEPGAMAAPEPGLRPEPVSAAGPGAVAAPGAAAAPDLGLGRPVLHTTGTVGEGDRRIVVVLTLHPAGGSFRMAATRLTELTGQVFRAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5H6</accession>
    <name>A0A1H6E5H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type branched-chain amino acid transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92950">
        <property type="protein sequence ID" value="SEG92950"/>
        <property type="gene ID" value="SAMN04489712_13625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296566" evidence="1">
        <location>
            <begin position="32"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="40"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="40832" checksum="AD81BA6E3252E67C" modified="2017-01-18" version="1">MSRPHRATLKALALAGAGALVLAACGGGSDAASGGEYNWGINAELSGATSAYGKTLQQGIQAYVDEVNAAGGINGHKIKLTALDNGGEQSRAAANTTQLATAHRVNVIFGNVLSSNCSAAQPVAVRNKVPLACISAAEHNPYVFNIGPDNARAATPLFEAAKKVTGKSDPKTAFVYLNTLTDLALAKDVQAKAAGAGIQLATAQEIDLMSTDYSSQTAKVVAAKPDVVLISHTGPGLLSVLKGVRAAGIQAPFVWLDGTANLTSLASSTDENVYAMTVYSLVQPDATEEGAKAYINAVKSKIKDSSTLMGLNDGEAVMGYLSAKAYGEAMKACGYPCSGEQLKQQLEKLQTSIPGIVDAFGYTADDHYPFKNWYLYNVVGSKATLTQTLAAGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E683</accession>
    <name>A0A1H6E683_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92395">
        <property type="protein sequence ID" value="SEG92395"/>
        <property type="gene ID" value="SAMN04489712_13340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021391">
        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="29365" checksum="2798BA3A70A8A44F" modified="2017-01-18" version="1">MSPLRQPRSAVTGAARTRRTRPPAVDPACADAVDLARAAAEETAHPTPVGEHLGTQPEAERVLTHFFECLDPAYKGWRWAVSVARAARAKVVTVNECVLVPGEDALMPPPWVPWIERLRPGDLGPGDLLPTPADDVRLAPGYTDAEDAEERQTQWELGLGRARVLSAEGRAEAAARWYEGTAGPRTPIAASAPAQCSTCGFYVMLAGDLRQMFGVCANEYAPDDGRVVSADHGCGAHSEAVVVPPSSEAPPPIVDEMGYDLMPVSSLADEEALGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E743</accession>
    <name>A0A1H6E743_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, luciferase family (Includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92989">
        <property type="protein sequence ID" value="SEG92989"/>
        <property type="gene ID" value="SAMN04489712_13638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="32132" checksum="DA95D53304B2C0E6" modified="2017-01-18" version="1">MTTDRAHAGLYLPQVRMDFAAIERRARAAEECGFHSVWFIDHLAPPAGRDLDMLDAWTVATAVAMRTERLRVGHLVLCAEFRHPALLAKMAASLDVLSGGRLELGLGWGSVARELTDYGFTDPGPAARAGRLAETIDILRLLWSGEPVDFDGEHWTLRAAVCRPRPVDGRVPIHIGGAGSRLTMPLVASRADWWNCPSSAADRLAELRPSAGAARISIQHPIGLAASSATRDEVVETTRRRFGAWGGVVAGTPDEVAEALSRERAAGAELFVCQFHDFGTPETIRLFAEEVLPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7Y0</accession>
    <name>A0A1H6E7Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93351">
        <property type="protein sequence ID" value="SEG93351"/>
        <property type="gene ID" value="SAMN04489712_13828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="7146" checksum="490DF11354FBEE18" modified="2017-01-18" version="1">MRQITLTREPDGIWIATQDGTPVATFYELGEDWWQGCFPNGARRQVYVPHGGEQEAARRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EA78</accession>
    <name>A0A1H6EA78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93826">
        <property type="protein sequence ID" value="SEG93826"/>
        <property type="gene ID" value="SAMN04489712_1411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="160" mass="16745" checksum="05E1D458BCD0D6AC" modified="2017-01-18" version="1">MLGRTSDPQVVRLYRMVKGERSAVIAMEAVNGVSLREFLAEHATQAPETALTVLKGSPQGLAAAHAVGVVHRDHKLANLVVQADGPSKPVDSGVAVLAGDGSQSGTPSHRTPEPLRPTITRGMAKPASDRPDSTHAFMVELEMTARAPYAATGRHVAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAB7</accession>
    <name>A0A1H6EAB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93765">
        <property type="protein sequence ID" value="SEG93765"/>
        <property type="gene ID" value="SAMN04489712_14032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="18"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="295" mass="31638" checksum="D58A924577013298" modified="2017-01-18" version="1">MIGHGATRRIGDLEVSAIGLGAMTLTQVPGYDAERGVRTVHAALDAGVTLIDTADVYGPAGGDYGVNELAVAEALRRYPGSTERVVVATKGGHVRFFDTDTWSIDGRPEYLRRACEASLRRLGLETLPLYLHHRPDPKIPYAESMGGLKELYDKGLVQRVGISNVSVEQVRLAHEILGPALVAVENEYSPRARDGEPVIELCEDLGLAFLSWGPLGGMRGAKDLGSAFGAFGDVAAARGVSPQRIALAWQMHRSPAIIPIPGASRPESILDSLAATDLDLTPEELQRLDRTPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBG4</accession>
    <name>A0A1H6EBG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000049">
        <property type="protein sequence ID" value="SEG94603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94603">
        <property type="protein sequence ID" value="SEG94603"/>
        <property type="gene ID" value="SAMN04489712_1493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296781" evidence="2">
        <location>
            <begin position="33"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="419" mass="41974" checksum="755BF1A2BAE45A3F" modified="2017-01-18" version="1">MAYRSAGTPVALGLGVAMILGTSTAAPALAFADEPSASPSEQTAEPTSEPTTSDPEPEPTTPSPDPSTPDPEPTTPDPEPTTPSPQPTSPDPEPTTPDPEPTTPSPQPTSPGPRPGPGGPKDPDKPGGGPTKPTDPTRPDDPPPGATVAVKLSLSSPVGSPGGSLTATAYVRSGAKAARDVRLVLSGAGFTVRQCTISVPCRLGAVGEGGESAPVTVYVPGDARPGSQITVYATVTAAQSTPQTASVVFGVTDGVPGPAGVLPPGGFPGGGLAPGSVGGLPQVVLPPVASPQIAPGVIQISPVAAIRDNDDSGPPALQRVAAVQAGWLSALLASISLLLASRPGLRPASRTARQAPGRSLIIDRDVRRRLNGKRPTAARLRALPPQPAPRPKAPPRIRVVWLPFRPGSVPVRRGGAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EC14</accession>
    <name>A0A1H6EC14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94325">
        <property type="protein sequence ID" value="SEG94325"/>
        <property type="gene ID" value="SAMN04489712_14614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="146" mass="15724" checksum="A05D1C470FFBDC17" modified="2017-01-18" version="1">MNHAAGSGEVDDRKLEELDRQECLELISPGGVGRVAFDDGEGPALMPVNYVVDGESVVFQTSVHGRLSRSLASLPAGAETRIAFGVDWIDDAAQKGWSVMLRGGAHRMSEEENAAAPRVESWAGGEREAHFRLTPTSISGRRVHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S226</accession>
    <name>A0A1H5S226_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43821">
        <property type="protein sequence ID" value="SEF43821"/>
        <property type="gene ID" value="SAMN04489712_10121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF43821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="198" mass="21716" checksum="70E857F9A2FE88D4" modified="2017-01-18" version="1">MTRADVPARPGRPRSARAEKAILEATVDLLAEEAGVAAVSMEAVAARAGVGKTTIYRRWPNKEKLIVDALATLKQPIPELSGQSVREDLVALARAIGHEQAGKHSRCHWNLLGGADRYPELLDRYRREVIEPRREVIRTVLRRGMRTGELRGDLDCEMVIAMLVGSMTLQARAPAPLKTLPDDFAEQAVDALLHGIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S6W4</accession>
    <name>A0A1H5S6W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase family M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46346">
        <property type="protein sequence ID" value="SEF46346"/>
        <property type="gene ID" value="SAMN04489712_101101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="416"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF46346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="593" mass="63549" checksum="7FBEF004D91CC714" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SI52</accession>
    <name>A0A1H5SI52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50289">
        <property type="protein sequence ID" value="SEF50289"/>
        <property type="gene ID" value="SAMN04489712_101221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF50289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="324" mass="34494" checksum="4558CE3E45BBC59A" modified="2017-01-18" version="1">MIEARGLTKRFGDKVAVDHADFTVRPNTVTGFLGPNGAGKSTTMRMILGLDRPTAGDVTVNGRHYRDLPAPLREVGALLEARAVHGGRSAYHHLWCLAQSNGLPRRRVDEVLGLVGLDSVAGKPTRGFSLGMSQRLGIAAALLGDPGVLMFDEPVNGLDPEGIVWVRRLMRQLAAEGRTVFVSSHLMSEMALTADHLVVIGRGRILADTGMREFIDANATSHVRVRSPHLDRLGPLLAERGWRVEDDSDGAVRVYGATADQVGDTAGEAGLWLHELAGVQPSLEDAFMQLTGESVEYQAGVPGARDGQAADAATVAMTQPGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SI82</accession>
    <name>A0A1H5SI82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CO or xanthine dehydrogenase, Mo-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50124">
        <property type="protein sequence ID" value="SEF50124"/>
        <property type="gene ID" value="SAMN04489712_101215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF50124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="807" mass="87192" checksum="2E5984D5FD48CE2C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJP6</accession>
    <name>A0A1H5SJP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, MSMEG_2516 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50843">
        <property type="protein sequence ID" value="SEF50843"/>
        <property type="gene ID" value="SAMN04489712_101242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019923">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03621">
        <property type="entry name" value="F420_MSMEG_2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF50843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="316" mass="34252" checksum="F68EACC5BC891C92" modified="2017-01-18" version="1">MGVRPFRFGVVVESARTAEDLVRTARRAEELGYATLNVRDHFVREPFGDQLAPMVALTAAACATRALRVGTLVLANDYRHPVMLAKEAATLDRLSGGRLELGLGAGWLREEYERAGLPFDPPGTRVDRLAEALHVIKGLLAGEEVTFTGDHYRVHGLSTFPRPARRPPILVGAGSPRMLRLAGREADIVGVLPPARPGGTIAGGFAERLPEAVDAQLVQVRRGAGKRWPSVELSMLVSPTFAGHPRRGAEAAAARRGWPPEAVDLIPRMPSQFVGPPEHMAEQMAGRRERYGFSYYVVADSAMEDFAPVVGLLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SM73</accession>
    <name>A0A1H5SM73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase-binding protein DksA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51713">
        <property type="protein sequence ID" value="SEF51713"/>
        <property type="gene ID" value="SAMN04489712_101276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="117"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF51713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="20315" checksum="CD3F319B85E29D0D" modified="2017-01-18" version="1">MPALPVEKPSARGTGMAGTRGEPASSGEVAERTSPAKRRRSAVRSAGAKDSARAGADHATAQAAELPVRGDEERWTETELAEVRTRLDGEIKALRAEILAAETQIAEGDTSDGAGDDQADTGAKTYAREHEMALAHNSRDLLAQSERAIARMDAGTYGICESCGKPIGKARLQAFPRATLCVPCKTREERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SSF6</accession>
    <name>A0A1H5SSF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53536">
        <property type="protein sequence ID" value="SEF53536"/>
        <property type="gene ID" value="SAMN04489712_101346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284278" evidence="2">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF53536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="131" mass="14186" checksum="89881CCE529C8A59" modified="2017-01-18" version="1">MMKRLAAAGVVSAALGGVLMTAPAAMAAGTDVSVTADWSGHHKDPGYWEGYGAGYGNGHKDGREEGYGAGYGDGRQDGREEGYGKGYGDGRQDGYGQGYGDGRKTGHEEHEKQEKKEKEKREKKEERHEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T0U1</accession>
    <name>A0A1H5T0U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56399">
        <property type="protein sequence ID" value="SEF56399"/>
        <property type="gene ID" value="SAMN04489712_101437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF56399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="127" mass="13593" checksum="59EA82F1AF13CFA2" modified="2017-01-18" version="1">MEESDALRAARAVRRSVLGDAYVDGQSADPDPAGREFQDYITSTAWGVWARGGALASRDRSLLVLAMTAALGRMEEFRVHAGSALRAGVTDEEIDELLFQIAAYCGVPAGVAARRVVRAVRAERGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T2Q5</accession>
    <name>A0A1H5T2Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57070">
        <property type="protein sequence ID" value="SEF57070"/>
        <property type="gene ID" value="SAMN04489712_101459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF57070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="44814" checksum="FDB599F1E4425A23" modified="2017-01-18" version="1">MVEYNPFSRETVHNPFPTYQRLRDEAPVYHNAEVGFWALSRYQDVIAAHLDTDVFSSAHGVTIEGVDQGAPFLIVKDPPEHTLHRKIVARMFTPRRIAQLEPFIRRTAAELLDRVRDADRFDLVQDFSFRLPLDVISELIGIPVAQREPIHELSDRIAARTEDGGTPQDVYEASAELWGILAELVRDRRRNPGDDVITLLMNTQVEDEDGTPRSLGDGELASRFLELAFAGHETVAKLIPNGVIALTWYPDQRRELVADPSLIPNAIEEMLRWDPPSHYQGRWTLREVELHGVTIPADQRVILITGSAVHDERKYPDPELFDIHRDIDRHVSFGFGRHLCLGASLARLETRVAFEELLKRFPDFGIDETGVQRQYSGNVRGLSSLPLLIERSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TIQ1</accession>
    <name>A0A1H5TIQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61887">
        <property type="protein sequence ID" value="SEF61887"/>
        <property type="gene ID" value="SAMN04489712_101610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="239"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF61887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="42432" checksum="7176BAB707D7BB96" modified="2017-01-18" version="1">MDFDLPESATAVREGVRAIAERYDQAYWDRCDADKRWPQEIWEELIKGGWTALAIPEEYGGAGQGLLELAVALESLAAGGAGGAASFMYLLTPAFGGLTIARHGTAEQRREFLPKIAAGELETCFAVTEPDAGSNAIAIATQATRDGDDFVVRGQKIWISGVERADFLVLVTRTVPAAEARPRVNGFTVLLVDVREAVAAGTLTYRPIPKLGTNTVASSMVFLDGVRVPADRVLGEVDQGFAVLWDILNPERILAAAAGVGFGELVLKIACDYARDRAPFGRPIGANQAVAFPLARVKAQVELARLMAYKAAWLWDRHRPCGAEANIAKLTAADAAWQAADRAFQTHGGMAYSLEYPVARFFRDARIGKNIPVAEELVLAHIAQHELGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V124</accession>
    <name>A0A1H5V124_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80904">
        <property type="protein sequence ID" value="SEF80904"/>
        <property type="gene ID" value="SAMN04489712_102117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF80904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="493" mass="50768" checksum="D9B0106FA3A65E6C" modified="2017-01-18" version="1">MSGSRIVIDGAGLTCAQVARVAREEVTVVAGRAGVERARTAWHVAREVTAAQPVYGRTTGVGANRLVNVEWEPEEAEGADTHGLRLLRSHAAGAGPLIAPESARAMLAVRLNQIAAGGSGVDPGVLGALADALNLGLVPPVPVYGAIGTGDLTALASTALCLLGERSWLATGDEGVRRGPGFALRSSDALAFISSNAATLGEAALAVTDLHTLLSASTVVAALSLHAVRGSVEPYAPAVHEACPHPGQQQVAAAMRALLAWERPVPVRIQDPYGYRAFPQVHGPAVDAAAHAERTVSLEINAAAENPLVDVVARTVWHNGNFHTAYVGLALDAARAALFQTAALSAARLGTLVEPSFTGLYPFQAATDVSSGIMILEYVAHSAIGDIRRLGGPAALGSAVLSRGVEEHAGFSTQSARATTEAVAGYRIALGCELVAAVRALRMQGRPPSGGPLREAYDLAAGTLDARVEDRPLDADIATAADLLPRLARLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V6N8</accession>
    <name>A0A1H5V6N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein (Putative glucokinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82401">
        <property type="protein sequence ID" value="SEF82401"/>
        <property type="gene ID" value="SAMN04489712_102168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF82401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="40793" checksum="2DA813F84479D82F" modified="2017-01-18" version="1">MRMTARPENLHQSRLLHLLRDEGPRSRAELGEMVRLSRSKLALELDRLVELGLVEPAGLAASRGGRRSAVVRLSPRLRFVAFDIGATSIDVAVTNGRLEVLGHVSEPCDVRLGAPAVLERALELLGKLRDDGLLPQVHGAGIGVPGPVSFREGIPVAPPIMPGWDRFPVREAIGRELGCPVLVDNDVNIMALGELHGGMARSVDDFLLVKIGTGIGCGIVVGGGIYRGVSGGAGDIGHIRVDDDGPLCACGNTGCLEAYFGGAALARDALAVARAGHSALLAERLAATGDVTAADVAAAAAAGDPAAVRLIREGGHRVGQVLAGLVSFFNPGLVIIAGGVARLGHALLAEVRSVVYRRSPPLATGNLPIVLSELGDTAGVVGATRLISDHVFSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V8X3</accession>
    <name>A0A1H5V8X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phenylalanine 4-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83663">
        <property type="protein sequence ID" value="SEF83663"/>
        <property type="gene ID" value="SAMN04489712_102215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016714">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="PTHR11473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="SSF56534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BH4_AAA_HYDROXYL_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF83663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="297" mass="33966" checksum="DC676CEE721C440A" modified="2017-01-18" version="1">MMEEAQYFAPVNQDEHGEVTVELAKSHPGFADPVYRSRRNALARLALDHRRGDPIPVAEYTAEEHEVWRLVSRELAAKHERYAIREFLEAKERLGLPRDRIPQLQEISEMLQPLTGFRYLPAAGLVPLREFYGSLADSYFHSTQYIRHHSVPFYTPEPDVIHEVIGHGNTLASDRFAALYRAAGRAARRVESQEALEFVSKVFWFTLEFGVMAEGSELRAYGAGILSSYGEIEEFRSMNIRPLDLATMGTTQYDITKYQDVLFRAESMDHLEDVAGAFWEECDDDSIDRLSRSTVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V9I7</accession>
    <name>A0A1H5V9I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DksA/traR C4-type zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83458">
        <property type="protein sequence ID" value="SEF83458"/>
        <property type="gene ID" value="SAMN04489712_102208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF83458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="121" mass="12988" checksum="28CAA9FD4A04300F" modified="2017-01-18" version="1">MGVRTTVDTAVAHHRLEAMLVDLDRSIALLKGENPGPGEPGFDKHPADAGADLSDADRVEAVLEALRRQRNAVLAALQRVAAGTYGRCVTCGKPVAEGRLEARPEAARCVACQARYDRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VBW3</accession>
    <name>A0A1H5VBW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83957">
        <property type="protein sequence ID" value="SEF83957"/>
        <property type="gene ID" value="SAMN04489712_102225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF83957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="549" mass="59464" checksum="9CEC3A6B5ABDCE3F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VQ96</accession>
    <name>A0A1H5VQ96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein YloU, alkaline shock protein (Asp23) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89469">
        <property type="protein sequence ID" value="SEF89469"/>
        <property type="gene ID" value="SAMN04489712_102415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF89469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="19743" checksum="AF1ACEF28E465DE5" modified="2017-01-18" version="1">MSQDSGKTTAKERSGPSRQESPGSTATAPTGPQATTGAGRRTELSPHGKGELITPTGRTTIVDGVVSKVAGIAAREIGGVHAMGSGMGRTLGSVKERLPGMGRNVARGVSVEVGERQAAVDIDLVVDYGVSIPDLAGAVRENVIRSVEHMCGLEVVEVNVTVDDIHLPGEDEGEEQGGERRGERAEPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VS91</accession>
    <name>A0A1H5VS91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90100">
        <property type="protein sequence ID" value="SEF90100"/>
        <property type="gene ID" value="SAMN04489712_102437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF90100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="28191" checksum="A02C758C6D7924F7" modified="2017-01-18" version="1">MSGFAEATAVSKVAEGRYTAELDGGYRIGEALNGGYLMAVLLRAAVDASPHAHPVATNTAFLRVGRPGPAEISVQTRKTGRTAATAWVTLSQGDVPIVDAQVTTGTLDPDAEPSWAGQAPPALPPLEECVGGAPSLAKDRGFADRVDMRFDPATMGWLDGQPSGRLEMSGHFRLRDDDYAPDAYLLALAVDALPPVVLNTGSPGWAPTVELTWHMRAVPAPGALTLYGGGRMVRDGWFDEEVEVWDSAGRLVAQSRQLARVGRQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WZZ1</accession>
    <name>A0A1H5WZZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05051">
        <property type="protein sequence ID" value="SEG05051"/>
        <property type="gene ID" value="SAMN04489712_10331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG05051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="22504" checksum="C34EBB7D64DB4FD2" modified="2017-01-18" version="1">MTDLPDRRVPSDPRELRASDADRERVAQTLREAAGDGRINLEELEERLTAAYTARTYGELEPLTRDLPIGAASGAGHLTAPDQRVTGGEPTSRMGVAIMSEFKRWGRWTAPRRFTSFAFWGGGKIDLTEARFSEPELRINAFAIMGGIDVVVPDDLDVTVRGFGIMGAFDDKATGPGVPGAPKVVVGGFSFWGGVAVKRRARKQLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X697</accession>
    <name>A0A1H5X697_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07269">
        <property type="protein sequence ID" value="SEG07269"/>
        <property type="gene ID" value="SAMN04489712_103107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG07269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="32204" checksum="D46275F5FEE07101" modified="2017-01-18" version="1">MGGWRAADIPDLTERRAIVTGANSGIGYHTALELARHGAAVVLACRSAERGGAALERIRAELPDADVTLAALDLADLASVRDFAAGHGARPLDVLVNNAGVMAIPRRATADGFEMQFGTNHLGHFALTGLLLPALLAAPAARVVTVTSALAWAGRMNFDDLNGERRYRRWQAYGQSKLANLLFAKELDRRIAGLTSLAAHPGYAATNLQTAGPRMAGDRLGERIMTMANRLVAQSDAAGALPSLYAATAPDARGGACYGPRGFQQRGLPTRVRTPPAAGDRETARRLWEASERLTGVTYETPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X9N2</accession>
    <name>A0A1H5X9N2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="3">APS reductase</shortName>
            <ecNumber evidence="3">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysH</name>
        <name evidence="5" type="ORF">SAMN04489712_103142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08135">
        <property type="protein sequence ID" value="SEG08135"/>
        <property type="gene ID" value="SAMN04489712_103142"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043866">
        <property type="term" value="F:adenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="4">
        <location>
            <begin position="55"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG08135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="26490" checksum="6A1FA1FAAFA398BB" modified="2017-01-18" version="1">MPSTTVLESPTDRPALDLRDIVDSAARALEGAPALEVIRWAVATFGDRICLTSSMSDAALIHLVSKVKPGIDVLFVDTGYHFAETIGTRDAVEAVYPVNVINVTPSRTVAEQETALGPRLHGRNPDLCCFLRKVEPLGRALEGYMAWFSGIRREETASRRDRKVIEWDGKRGMVKVNPILDWTQQQMDDYVSDNGILVNPLHHDGYPSIGCAPCTRRVAPGEDPRSGRWAGLGKSECGIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XH30</accession>
    <name>A0A1H5XH30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11134">
        <property type="protein sequence ID" value="SEG11134"/>
        <property type="gene ID" value="SAMN04489712_103255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289428" evidence="6">
        <location>
            <begin position="26"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG11134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="21418" checksum="72D2AA485985EC0A" modified="2017-01-18" version="1">MGSAQLLVFAGVVQLAVMAPGPDFAVTVRNSAVSGRRTGMMTALGIAAGIVGWSLGAALGIAALLATSATAYTVVKLVGAAYLLFLGVRAVRAALRGDYTAGTSGAGERAEPGPWTGFRQGLLCNVLNPKAAAFYVALMPQFLPPSPGPADTLVLSAIAVTLTGVWFVVVANVVVALRRMFDRPAVRRRIDAFTGIALVGLGLKLAADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XHF7</accession>
    <name>A0A1H5XHF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10807">
        <property type="protein sequence ID" value="SEG10807"/>
        <property type="gene ID" value="SAMN04489712_103242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="140"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG10807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="353" mass="37793" checksum="8E3E4D866C747E94" modified="2017-01-18" version="1">MPVHLPPDEARRFLETGELPAPHLDVIAAMAFHAAAAGVALGVFDALAAGPRTAAALAAELDAAPDALGVLLEVLAATGYLERATKGYRNGLAGRALTDGYGGTLRFWHDVITGLWGGLEHTIRHGERAADFYAWLPEHPDTLERFRNLLRAQAGWLAEEIVDAVPLPPGAARLLDLGGGHARYTAAYCDRYPGLRATIVDLPSARPEPLPERVTLRHGDLLAGWAERDQDCVLMFNLLHGFPTGRARALVRDAVASLRPGGLLLILDRFPGEREGVAGAAFTRAFELNLLHTQGGRLHSPDEIAIWITDAGGTPPARHRLDRSPGHALLASVRGPSGTRPAGPRPRSPRADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XMH4</accession>
    <name>A0A1H5XMH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase, MGT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12951">
        <property type="protein sequence ID" value="SEG12951"/>
        <property type="gene ID" value="SAMN04489712_103322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG12951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="42459" checksum="93082ACEC599C1E0" modified="2017-01-18" version="1">MIPGLQGGGSRGSRFLFAVPPLAGHVNPTVAVGAELARRGHEVAWVGHPPDVRPLLGNGARLYPAPGEEFTPLLEAARREGRALHGPAAFRFLWEGFIVPLGHVMMPGVEAAVEDFRPHVVIADQQVLAAPVVARRRGLPWATSATTSAELARPMAAFPRIERWAGDLIEDFQRAYGDPDPMDLRFSDYLVLVFSTPALVDEAEGCPDHYAFVGPALGRPSSGTFPWRWLDGERPAILVSLGTVSADPRERFFGVAAEAVAGLDVQAVFVAPPEAVPDPPPNVLVRRHVPQLALLPRLSAVVSHGGHNTVCETLAHGLPLVVAPIRDDQPVNAHQVARAGAGIVVPFFRVRPPRLREAITTVLTEDSYRHAACAVQASFRTAGGARAAADRLEKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XNX8</accession>
    <name>A0A1H5XNX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13479">
        <property type="protein sequence ID" value="SEG13479"/>
        <property type="gene ID" value="SAMN04489712_103342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG13479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="410" mass="42642" checksum="81B2BF6EA3556EE6" modified="2017-01-18" version="1">MRSDDPEDSPVALADDSHDVRPRRAVWPAIVAVALSASVFTVMQGLTYPLLAVLLDRGGVSEGLNGLNAAMMPLGMLLAAPAASPLVRRLGAYRVAVVSLVTVAGCLLAIGAVRHPLPWLPLRLAIGFFLACIFVTTDTWINELAPERLRGRILGLYSALLSVGFAVGPALLTLVGTRGWAPFLLGACCPIAALLPLMLTRGSLPSRGRQEEGMRLRAFLPLAPLLLLCVGAAAFADQGAMSLLPLYALREGLSEDGANLALVTMISGSIALMYPIGWLADRISRPVMLAACALLTAVCAALLPVGVHSPGAFGALVFVWGGAYYAIYTLSLVILGERFYGPALVAGSAAFGALWGVGGMIGPPVIGTSMRLLGPGGFPLTFTLIFLAVAVTLGAAAARSRPRPSSDHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XPJ3</accession>
    <name>A0A1H5XPJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13425">
        <property type="protein sequence ID" value="SEG13425"/>
        <property type="gene ID" value="SAMN04489712_103340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG13425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="311" mass="34759" checksum="4ECADB1567A989AB" modified="2017-01-18" version="1">MADTHTTRPAAEDEDFIKAKYDFTAVYNDPSPRPLMRVYRELNYCVPYHIEHFIAALVDMAGKARGAPRVRVVDVGCSYGINALLLKHRMGYRRLSATVLDGGLPDADLPGMLAGRATGQRPVDVIGFDVSPNAIDFCRRTGVQDRSVLADLERRDVPADARDDVAGCDVVLSSGVYGYISERTMGRLVTASDNDRGVPWVCNFALTPIDYTPTAALLREFGLVTETAPVLFPHRRFNSPVEREATLAFNRRAGSDSAAERKTGYLYTRCYISRPAEFARRLPLEPFWSREIPRHLASRLLPDPLHQQWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XVX9</accession>
    <name>A0A1H5XVX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15828">
        <property type="protein sequence ID" value="SEG15828"/>
        <property type="gene ID" value="SAMN04489712_103432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG15828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="55" mass="6052" checksum="3CFC7EA630CA27E4" modified="2017-01-18" version="1">MTSADRTQNDLGRDAWKPVDEGWGRRAARSAALRAPTLVVGHLARKPLSPEESPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XXI2</accession>
    <name>A0A1H5XXI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Formate dehydrogenase subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16411">
        <property type="protein sequence ID" value="SEG16411"/>
        <property type="gene ID" value="SAMN04489712_103456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="4">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG16411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24164" checksum="96D7FB86AA4CF41A" modified="2017-01-18" version="1">MLARFTGAERAVHHATAVLMLVCLGTAACLYVPDLATLVGRRSLLRTVHVWCGFALPVPMLAGWLSRAFREDVRRLNRFGPRDREWLRRADRRAVAGGRGVVPVGKFNAGQKLNAAFVAGAILVMLGTGAVMSFPDPWPVGWRTGATFVHDWLTLAVLAAVVGHLWYALRDPGALGGMWHGRVGPEWAARHHAGWLDELVKAPDPRQERSVKTANPDSAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZM3</accession>
    <name>A0A1H5XZM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17072">
        <property type="protein sequence ID" value="SEG17072"/>
        <property type="gene ID" value="SAMN04489712_103483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="30925" checksum="CEA5A97535218FDD" modified="2017-01-18" version="1">MDVIEANGLEFGYLAEGPADGPLALCLHGFPDSAHTWRHLLPALAAAGYRAVAPFMRGYAPTSVPADGAYQTGALAADANALHEALGGGPDAVLIGHDWGATAVYAAVGHEPGRWRRAVAMAVPPNPVLLSGFLTYEQLKRSFYIFVFQTPLGEMALNRAFVEGLWRDWSPGYDADRDVSHVMDCLSAPGNIAAALGYYRAMLDPSRHVAAYAAQQEAADRVGERPILYMHGVDDGCLNVEVAGGATGALPHLPPGSRVELVERAGHFLHLERPETVNAHILDWLAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y1B1</accession>
    <name>A0A1H5Y1B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17761">
        <property type="protein sequence ID" value="SEG17761"/>
        <property type="gene ID" value="SAMN04489712_103508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="124"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG17761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="46948" checksum="402B10C78EE568CF" modified="2017-01-18" version="1">MREGTPLFTTGRRMLGIAFVLVLSLLVWLSIAAYQKKFTAADMVTLHTGSAGNEMHRNADVKLRGVVVGQVREVRADGGGARLTLAFKPGMLDHVPANVTAQMLPTTLFGQRYVALIPPVQPAGQPLAPGSVITQDRSQNAIELEQVLENVLPLLTAVKPERLAATLTAVADALEGRGDQLGATMVKLDAHLKKLNPYLPQMNRDLRELVRVSHAYADAAPDILDALEDFAITSRTIVDQRGNLSDLYSSMTSSSRYLTEWLRANRDNIIWLSANSRPSLELMARYSPSWPCTLRMLRDFVPSMDRALGKGTGKPGLSVTVKVVPSKGRYRPGKDRPVYNAGGGPRCYSVPYDGVGTVPGNGLTGWGTPPAVTPTTPTAPAPGGRLLGLPNSPEENQQLNELLAAQVGRPHDELPDWSSVLVGPIYRGTEVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YUF1</accession>
    <name>A0A1H5YUF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed RNA polymerase specialized sigma subunit, sigma24 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27614">
        <property type="protein sequence ID" value="SEG27614"/>
        <property type="gene ID" value="SAMN04489712_104187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG27614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="566" mass="60493" checksum="AF82E9FAC110DE44" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A7K0</accession>
    <name>A0A1H6A7K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted ABC-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44723">
        <property type="protein sequence ID" value="SEG44723"/>
        <property type="gene ID" value="SAMN04489712_105267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="16412" checksum="768AC0A8C5F60E32" modified="2017-01-18" version="1">MSVLTVVVGPPCSGKTTYVQAHAQDGDIVIDLDLIAQALGSPVTHGHADAITRTAQAARRAAITTAIRQHHRGARVWIVECDPSRQRRAEYHRAGARFVPMQASRAELHRRAADRPPHWHTLIDQQLARQSPQTHDRDARTTRTGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AKB0</accession>
    <name>A0A1H6AKB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48842">
        <property type="protein sequence ID" value="SEG48842"/>
        <property type="gene ID" value="SAMN04489712_105500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG48842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="28689" checksum="7C133B12BD418951" modified="2017-01-18" version="1">MQSQVAALADFEIAHLYPERGLVMTGALDELRTEALETLSPGSYRSTHGDVITAPEEVFRLLDTFLEKRLVEAFGSLEERKHWDDDEEAGPLPAGPGPYGSGIRALGGTGERIELAAGWNSRQLLASFAEEDEGPDDDAPHAREPWQEVIGDRGMLREWLCHMMRWTDNDGHFTMYPRTEQERAWLTETKASRIELADRLLMAFPPESSRYFIGGHAGWDRWSEDYLSRDEVIAFVSGDDVAVLWLSFYRFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AKN6</accession>
    <name>A0A1H6AKN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49111">
        <property type="protein sequence ID" value="SEG49111"/>
        <property type="gene ID" value="SAMN04489712_105515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG49111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="48" mass="4847" checksum="2B69E49E4CE3FFED" modified="2017-01-18" version="1">MSLLLCVHDVASGAAGLVRLLADPIDNPAPADPTNGSKGISLLLSYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ANF2</accession>
    <name>A0A1H6ANF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty-acyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49575">
        <property type="protein sequence ID" value="SEG49575"/>
        <property type="gene ID" value="SAMN04489712_105539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="413"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG49575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="507" mass="54694" checksum="AD6EF701E13F62B0" modified="2017-01-18" version="1">MSDANGQMTFAHAFWRNVRERPEAVALADRNVELTYADVGSRAAEVIAELERLGVRRGDRIGIAAPNRLDVVLVMVAAAAAGVTVAPANWRLPAAAAAEYLGGVAPSAVFCSHAHRAVAEGVPGAAVIDLDEDPRWRARPGTGRHGLDPHRVSGSDPMTIMSTSGSTGRPKGVVISQAAMVARALVLHAELGVDALDSFVGWAPLFHISSTDYLYASLILGGTFVVHQGFDPQAVTRELLDRDVGWLFLIPGLIPELLAALGERRPRRVKYVGAMADLVAPNQLRDAEERLGAPYLNTFGSTEAGLVPGAGPVAWDGGRPRLDKRVTMFCQHRIVNDQGEDVEPGVPGELWLRGPTLFSGYWEDGRLSRAAFRGGWFPTGDLVRATATNAIEFVERRGRMFKCGGENVYPATIERTFLAHPAVGEAAVVPVPHPRFQQVPAAYVALAEEIDTATLLEECATGLAAFERPFAVHVLGPEQFPRGVTGKVVRDRLAEEHPRCGPECWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AVF8</accession>
    <name>A0A1H6AVF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">SAMN04489712_1063</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52055">
        <property type="protein sequence ID" value="SEG52055"/>
        <property type="gene ID" value="SAMN04489712_1063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG52055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="223" mass="24684" checksum="2AD6849547C1BC27" modified="2017-01-18" version="1">MSDLIRPGMRADGGVAPAQSRYIIPSFVERTTYGVKEMNPYNKLFEERIIFLGVQIDDASANDVMAQLLTLESIDPDRDISIYINSPGGSFTAMTAIYDTMQFVKPDIQTVCIGQAASAAAVLLAAGTPGKRAALPHSRILIHQPATEGTYGQSSDIEIQAREIMRIREQLEEILARHSNKPLEEVRRDIERDKILTAEDAKSYGLVDDVFVSRKRRAEVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AX10</accession>
    <name>A0A1H6AX10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52790">
        <property type="protein sequence ID" value="SEG52790"/>
        <property type="gene ID" value="SAMN04489712_10654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="32729" checksum="17907AFC6E8754CF" modified="2017-01-18" version="1">MPSPFVRRLRLAAELRALREERGMTADELSRLLYQSRPKVSKLENGHLRPDLALVMKILDLLDVTGDKWHEVVTIARDAAERGWWDRYGAAMGDRQRMYADIESGAKSIRGYNQFGIPGILQTPEFTMALVELDKADGPLDYSPERMIKARLQRRKAAFGPEGLTYELILDEFVMRRLAVAPEVMSAQLLHLVETASYEPRLTVHVLPMDARIEGGFLARSTFAIYTFPDPNDPTMAIADTVNTDVVHTATTEVARYIELYQRLRDASLSAVSSLTFLEEAANRLAKMAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXE6</accession>
    <name>A0A1H6AXE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR02677 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52940">
        <property type="protein sequence ID" value="SEG52940"/>
        <property type="gene ID" value="SAMN04489712_10663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013493">
        <property type="entry name" value="CHP02677"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09660">
        <property type="entry name" value="DUF2397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="509" mass="56836" checksum="D3D4C5E57176E24B" modified="2017-01-18" version="1">MDEAELPEEQGEGPDLWAGALPGQVMVPAYLVSRYAAQYRVIVDVLLAAMDTNLTGMSYDKVAHAVTERVRALAGTDTAERLLEGSNFALEARLGRLVAWKVVTRWQEPARTGEDFLRRRDRYQLTPLAARLHAFWAETDDADDEAADLTLAPRAIHDRLKAFTEAMAEERYPAAASEFQQVIALHHAMARAARSWQRTLAHNLSGTPDEAKQEQVGRTLRAYIAMWGEQVDVYSPRIADMVTRTPSSGAWRACARGALAEHPDEEMVQAQAERWEQTWHALQTWFCGPQAQARRLRRQLRDVISPWARNTHFLMEAGGVVTRRAELLELAAVIERAPDETTAWRLWDTALGVFSARHLLVPAESLEDDTETWESAPPAPVPAKFREQGHRAMVGRRPRRADYAAGRDAARRERAKLAAARAAAEAALRRRSGTRLSQWPRLDGAELDLLLELIAAARRSGPGHEAITQDGRWRVRLGDPADPADVATLIGPDGRLVTVDWMFELQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AY50</accession>
    <name>A0A1H6AY50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine rich repeat variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53005">
        <property type="protein sequence ID" value="SEG53005"/>
        <property type="gene ID" value="SAMN04489712_10667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004830">
        <property type="entry name" value="LRR_variant"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01816">
        <property type="entry name" value="LRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="15209" checksum="753A35A37DCA0EB8" modified="2017-01-18" version="1">MPGEELERLVCEHGEDFSVSPLLVEHPNFPPQAFLRLAESDEPSIRHLALKNDDLPATLVSVLAVDPAPHVRRAAAEHRNLPVSCLPALLTDDDLQVVEAAGAAPAFPTPWMHQLLDAHPSRPDRSGSSSSGPRGGGVVRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYT7</accession>
    <name>A0A1H6AYT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkylhydroperoxidase AhpD family core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53751">
        <property type="protein sequence ID" value="SEG53751"/>
        <property type="gene ID" value="SAMN04489712_106114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG53751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="18060" checksum="152CE963803A4582" modified="2017-01-18" version="1">MNIDIPEGKDPIGYVWGEMVPGIGPAAAHLSLAVYEHTTLGLREFEAARLRIAQLNGCLFCLDWRTERDGHKVEEGFADAVTQWRTTDAFDERTRLAAEYAERYVLDHHGLDEEFWTRMTAHYSQAEIVELSMCIGSWLAFGRLNHVLGLDAMCVLPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B420</accession>
    <name>A0A1H6B420_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Poly(ethylene terephthalate) hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.101</ecNumber>
            <ecNumber evidence="4">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_106186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12420"/>
            <dbReference type="Rhea" id="RHEA-COMP:12421"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:131701"/>
            <dbReference type="ChEBI" id="CHEBI:131704"/>
            <dbReference type="EC" id="3.1.1.101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:49529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47348"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:50477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:47349"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.101" evidence="8"/>
    <dbReference type="EC" id="3.1.1.74" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="9actn-a0a1h6b420">
        <property type="family name" value="Chlorophyllase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54886">
        <property type="protein sequence ID" value="SEG54886"/>
        <property type="gene ID" value="SAMN04489712_106186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="Chlorophyllase2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="Chlorophyllase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG54886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="313" mass="32793" checksum="5C116A2CA5C16C75" modified="2017-01-18" version="1">MTGPVTVRSLWWSAQTGGPPPFGTAHLKVYYPARAEGTDAERLTGVFPPDPQGAPYPVVVFCSGVNVEQSVYRPLAADIAAAGFVVVTFDRVAELFGGQVGLTPGVDLDAARPDAYGTRPTCPAIGAVLDALGDIDLLKGMLDLDRIALGGHSAGGTVVLQSARFFPGVRACFAYGTHTMVATMLGWPPGTVLPAQVRCPVLLGVGTRDGVIAGSSDRYGQSAPADPVTRTFTEALTDPGDLLAVLKGANHFAVADPVDPTAARAFLDLDTETDPAASRRAYTDLVVAFLRAHLRDEDVTPSADPALVDLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B576</accession>
    <name>A0A1H6B576_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55999">
        <property type="protein sequence ID" value="SEG55999"/>
        <property type="gene ID" value="SAMN04489712_106276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045443">
        <property type="entry name" value="DUF6504"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20114">
        <property type="entry name" value="DUF6504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG55999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="94" mass="11043" checksum="25B1DF70DA104459" modified="2017-01-18" version="1">MARVFGDPIEVVVACGRPVEFTWRGRPHRVLRVLEHWITTRNWWNEQHTGDPFWENPGEREFWKVEASCGDELVLCELRHESAADAWTLSRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BES7</accession>
    <name>A0A1H6BES7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitinase A, N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59273">
        <property type="protein sequence ID" value="SEG59273"/>
        <property type="gene ID" value="SAMN04489712_10758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013540">
        <property type="entry name" value="ChitinaseA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08329">
        <property type="entry name" value="ChitinaseA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293684" evidence="3">
        <location>
            <begin position="26"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="PGRP" evidence="4">
        <location>
            <begin position="187"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG59273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="681" mass="71078" checksum="64A5FF74221D230B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BGX3</accession>
    <name>A0A1H6BGX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59476">
        <property type="protein sequence ID" value="SEG59476"/>
        <property type="gene ID" value="SAMN04489712_10771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="153"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="153"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG59476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="773" mass="83291" checksum="39E4450905F7CAD5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJM6</accession>
    <name>A0A1H6BJM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60938">
        <property type="protein sequence ID" value="SEG60938"/>
        <property type="gene ID" value="SAMN04489712_107169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG60938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="46" mass="5167" checksum="321DD838F2B85662" modified="2017-01-18" version="1">MLATVRVGVEEEGYARLREFADRVAVLLRTVRAGDPVTRTRRAPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJT0</accession>
    <name>A0A1H6BJT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Competence protein ComEA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60904">
        <property type="protein sequence ID" value="SEG60904"/>
        <property type="gene ID" value="SAMN04489712_107166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="94"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG60904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="237" mass="24704" checksum="F8DE2D8212B174BC" modified="2017-01-18" version="1">MIHRDVFEDFFEPVSKGTHHVVGEQRIDDRWGRLSPGRPGARALALVGLLAVLLAGGYLWASRPRPQPPAGDVPAPSAAASPTVLAEPTPAGLIVHVAGKVRKPGVVTLPVGARVADAIQAAGGLRPGARTGSLNLARRVVDGEQLMVGLPAPSTPAVQPGAGPTAPQGTGAPGEPLDLNTATVEQFDTLPGVGPVLAQRIVEYRTRHGGFRSVEQLQDVTGIGERRYAELKPLVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNV8</accession>
    <name>A0A1H6BNV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_107276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62145">
        <property type="protein sequence ID" value="SEG62145"/>
        <property type="gene ID" value="SAMN04489712_107276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG62145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="21962" checksum="594B4B553343E528" modified="2017-01-18" version="1">MASERREHLVRLAAELFAQKGFQATTVRNIADEAGILSGSLYHHFDSKESIVDEILSGFFDEIMASYRAAIDRGQGPRETIAALVRAAFDTLEPHRAAITVMQNDWSYLRGMERFAYLTKAEDEIEEMWAGTIRQGQRQGLFRADIDATLTYRMVRDTIWMAVRWYRPGSGLDPKTLAEHYLKVMFDGINIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPY2</accession>
    <name>A0A1H6BPY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_107319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62753">
        <property type="protein sequence ID" value="SEG62753"/>
        <property type="gene ID" value="SAMN04489712_107319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG62753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="20262" checksum="008103263798D8AA" modified="2017-01-18" version="1">MLTTSDVSPTGRNLTAAAVLVVALILQVSVANRLPLPGAVTPDLVLLTVVALALTGGPLTGVVAGFCAGLAADIIPPADHTIGRYALVYCLVGYVCGLASDDMDRSSVVPFLAVAAGALGGAVLYAGLGMMLGDPRASWQIVSRIVPLQVVYDVLASPFVVWAVLRVTRRFDRERTRGRFDLPAARYRALSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYU8</accession>
    <name>A0A1H6BYU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65813">
        <property type="protein sequence ID" value="SEG65813"/>
        <property type="gene ID" value="SAMN04489712_108138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="76" mass="8132" checksum="588F1A293893D6AA" modified="2017-01-18" version="1">MTDTNEDTSEYAATFGMVDLDGDGFISLEELKTLMRALGQEISHARAVEVMVAADGSRDGKLSLAEFAAFMAANAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZ39</accession>
    <name>A0A1H6BZ39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose:LPS heptosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65747">
        <property type="protein sequence ID" value="SEG65747"/>
        <property type="gene ID" value="SAMN04489712_108131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="352" mass="36231" checksum="6183E22FD0256CA8" modified="2017-01-18" version="1">MALTERERPSGRALVVRLDSAGDVLLAGPAVRAVAARRAHVTLLTSPLGEAAARLLPGVDEVMVWSAPWVLADPPPVRPEAVAGLVDALAAGRFDDALVLTSFHQSPLPAALLLRLAGVARIAAISVDYPGSLLDVRHRVDEDIPEPERGLSLAAAAGFPLPPDDDGRLAVRRPLPPTAHLTGDGPYVVVHPGAAAPARQWPPERCAQAVTELTARGWRAVVTGGPSERELTALVAGRDGVDLGGRTDMPGLAGVLAGAAAVVVGNTGPAHLAAAVGTPVVSLFSPVVPPARWAPYGVPAVLLGDQLAPCRDTRARVCPVPGHPCLAEVTAAEVADAVEKLATYTHDGSDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C264</accession>
    <name>A0A1H6C264_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_108220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66745">
        <property type="protein sequence ID" value="SEG66745"/>
        <property type="gene ID" value="SAMN04489712_108220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294354" description="Peptidyl-prolyl cis-trans isomerase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="218"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG66745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="32194" checksum="F1A1470CECB1DDA3" modified="2017-01-18" version="1">MRRLVPFAAALAAAPLVLTACVGGDDVPVKVTGEYGERPEVSFPKDTEPGDELVTSTLVTGKGAQVAKGDLVIASYAGYRWNDAGSRLIASSYAAGQPGAFPSGKLVPGLDRALIGQKTGSRVVAVIPPDQGYGSQGDARHQVGAHDSLVYVLDVLATYSKNAQAKGTAQPLEDPRLPKVAAAAPGRSPRVTVPRAAPPSTLQVRTLVQGSGPAVRSNQLTVLQFTGVLWRTGKEFYSTWSDGRPAGEVLGVGQDIKAFDEGLVGQKVGSRMLLVVPPKWGYGAKGLSHYGIKGDDTLIYVVDILGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2W0</accession>
    <name>A0A1H6C2W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mycofactocin system transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67223">
        <property type="protein sequence ID" value="SEG67223"/>
        <property type="gene ID" value="SAMN04489712_108265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023851">
        <property type="entry name" value="Tscrpt_reg_TetR-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03968">
        <property type="entry name" value="mycofact_TetR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG67223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="24301" checksum="3DF3B09E942C2D76" modified="2017-01-18" version="1">MPETTDRPSAARAPRVGRRPRTSRAELEQVALRLFAERGFEETTVDDIAAAAGIGRRTFFRYYGSKNDVVWGDFERELEHMRAWFAGCPPEIPMMDALRRAVVAFNRLDPDQVPWHRLRMMMILQVPALQAHSTLRYADWRAVVAVFVAGRLGQPADALMPQAIAYACLGAAVASYEQWLRHDDADLGELLNRAMSALAHGFQGALDPPGPVSGQTPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C4E4</accession>
    <name>A0A1H6C4E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized zinc-type alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67505">
        <property type="protein sequence ID" value="SEG67505"/>
        <property type="gene ID" value="SAMN04489712_108294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG67505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="36654" checksum="AAA2487F5E51648B" modified="2017-01-18" version="1">MRVHAYAAPAAAEPLVPTVIERRDVGPNDVLIEIKYAGICHSDIHTVNGDWGPQSYPLVPGHEIVGIVTEVGADVTLHQAGDRVGVGCMVNSCGECTNCRNGNEQYCLNGMVPTYGAVDRDGTITQGGYSTHVVVDADFVLSVPEGIDFAAAAPLLCAGITTYSPLRRWGAGPGKKVAVVGLGGLGHMAVKFAHALGAEVTVLSQSLKKQEDGLRLGADHYHATSDPDTFERLAGRFDLIVNTVSARIDVDAYLGLLAVDGTLVNVGAPAEPLSLTVFSLLNARRSYAGSMIGGIPETQEMLDFCAEHHIGADIELISADRINEAYERVLASDVRYRFVIDTATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C551</accession>
    <name>A0A1H6C551_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein E (SpoIIE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67486">
        <property type="protein sequence ID" value="SEG67486"/>
        <property type="gene ID" value="SAMN04489712_108292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="321"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG67486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="573" mass="60530" checksum="E321F6326D3383D9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C6X2</accession>
    <name>A0A1H6C6X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HupF/HypC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68711">
        <property type="protein sequence ID" value="SEG68711"/>
        <property type="gene ID" value="SAMN04489712_10914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="6787" checksum="FF439E0981F12B0E" modified="2017-01-18" version="1">MTPGEVCVTCSDTAVPVRVRALLGDGLALVDTEAGAEKVSVALVDARPGDVVLVHAKEAIAVSERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C787</accession>
    <name>A0A1H6C787_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase, sigma subunit, ECF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_1095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68597">
        <property type="protein sequence ID" value="SEG68597"/>
        <property type="gene ID" value="SAMN04489712_1095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="124"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="200"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG68597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="317" mass="35044" checksum="FF364F3395AA14FE" modified="2017-01-18" version="1">MSAELVAAAQDGDGEAFRRLVEPFRGELYAHCYRMLGSVHDADDAVQETLVRAWQGLRRYEDRGAVRAWLYRIATNRCLSMIERRGRRELAADPKAEAVRVEPCPEERLGPEDAVVAREGVELAFVAALQHLSGLQRAVLVQREVLGFSAAEVAEMLGTSVASVNSALQRARRVVAGLLPETTQRETLRRLGDRAVRDLARRYAAAWEAGDVEAIVAMLTQDAKYSMPPLPAMYQGHEDIRAFLLEGPLATRWRFLPARANGHLAFGTYMWNAERGVYTPGGLDLVTLRGTRIAEVVSFLTVDLTAFGLPEELAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8G7</accession>
    <name>A0A1H6C8G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69270">
        <property type="protein sequence ID" value="SEG69270"/>
        <property type="gene ID" value="SAMN04489712_10967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="334" mass="35434" checksum="78C115D0727E6F3F" modified="2017-01-18" version="1">MIACYVRGEGLGHLTRLRAALHTLGLDGEPVTVLTDSSFAADPRVTGGWTVLRAPSSTGLADWIAATLADLAADELFIDAFPAGLKGELTAAAIPPGTSVVHLARLLRWDAYRPLLPTDPPRFDRTYMLEPLTPEHDAHLRSVSREVTPLTLVEPPVTGHPSPSAPAAVPGGRFRPGAWPDASTAFLAASGARPPSGTRLPAGVRPAGHGGEPVGPAEAAATLGPGAWLVVHSGPDAEIGELVAYARDLAAVEGLSPRLTLVSPHRPADLPAQIAHLDVYPVWPLFPSAERIITAAGFNAVRQLSPWRDRHRMLPFPRTLDDQFTRAARTRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIV4</accession>
    <name>A0A1H6CIV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72683">
        <property type="protein sequence ID" value="SEG72683"/>
        <property type="gene ID" value="SAMN04489712_11026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="201"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG72683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="34877" checksum="C884FC3145B772C9" modified="2017-01-18" version="1">MSLVPDSAVLEQWWQRYRGELTGYCYRMLGSAFDADDAVQETLVRAWRSLDRFDEARGKPRSWLYAIATNICLDMLRGAERRARAVDLGPASRPGEALGRPLPEERWVLPVPDGRLDPAEVVAARETIRLAFVAALQHLPPRQRAVLILRDVLRWKSAEVAGLLGGTVAAVDSALQRARTTLRAPGPADPLDEAGRRLLDGYCDAFERHDVDRLVSLLHEDATMSMPPFAWWLRGREDIRRALLAPAAGCLGSRLVRVAANGSPAFAQYVPTGPGGAFEPRALVLVDVRAGRIAATTSFLNTDRLFPLFGLPPSLGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLX4</accession>
    <name>A0A1H6CLX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73446">
        <property type="protein sequence ID" value="SEG73446"/>
        <property type="gene ID" value="SAMN04489712_110111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="297" mass="31045" checksum="48619550671613CC" modified="2017-01-18" version="1">MPTQFAGRTGRTPSLTGRRVLITGAARGIGAALAERLHARGARVALAGLERDALAEVAARCGDAPWRACDVADREQVEAAVAGAVDALGGLDVVVANAGVAAQMPVIGGDPSVMEHTVRVNVLGTYHTLRAAGPHIAHRRGYALTVASLAAAVHLPLLGAYSASKAAAEALGNTMRAELRPYGARAGVAYFAELDTDMTHRGFGTRAAATLMGSRSAIAAVSRVTPLEVGIDALERGIAWRSARIVAPWWVAGVLPVRMLAQPVVDRVVQRRLRDALEIARDETVPLTTAQPGADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CR29</accession>
    <name>A0A1H6CR29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75450">
        <property type="protein sequence ID" value="SEG75450"/>
        <property type="gene ID" value="SAMN04489712_11140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="36" mass="3925" checksum="7B7817F9DBC5C179" modified="2017-01-18" version="1">MTSNRNQISPLPAGDRLLTVAEAAELLNTSQRFPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSB4</accession>
    <name>A0A1H6CSB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell elongation-specific peptidoglycan D,D-transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75738">
        <property type="protein sequence ID" value="SEG75738"/>
        <property type="gene ID" value="SAMN04489712_11177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="489" mass="52437" checksum="C07DFC82AEB3B63E" modified="2017-01-18" version="1">MDKPLRWVTVFGLLLIFALMVQVNYIQGSQAEKLQTHDLNNRQFLDVFKRPRGKILAGGEVLVSSTKPKESENYARTYKNGEVFAPVTGYFNGGANGIERAYNSLLDGRDKRITNQRWFDQFIGKKALGADVETTIMPAAQRRAYEELRRANPNLRGAVVVMDIRTGAIVVMATYPSYDPTDVAPQTGLKGGERLVELEGKPNSKGEVNERNKRLKPLINNVLEDTFSPGSSFKALIAASALENGYSKDSAVPAPSTYLLPGTRTSLPNSHEGGACGGAGTAPLISTFAESCNTTYGILGAQELGTAKVLETAKEFHYDQRIKVEPDLSSVQSAFPDADGARTALASIGQGDNNATPLHIMMIAAAAANDGRIMKPYLVQRVRAADQSVLEEADPQQLAEPLSGGQADQLADMMRAVTSTGTAKGVGDVAGKTGTADIDGVEYNNRWFAGFAPAQNPRYAFAVFTQGIGSGGEAAAPIAVNVMREVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSR9</accession>
    <name>A0A1H6CSR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76060">
        <property type="protein sequence ID" value="SEG76060"/>
        <property type="gene ID" value="SAMN04489712_111117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG76060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="13069" checksum="34DA9C7E6B1FCD2B" modified="2017-01-18" version="1">MPEVKGGPVPCRVTVCRDCCCGSAKVTGIDHDEQVAFLCGQVPVRVSECLDVCEQANVIVVQPSAAGRAAGARPVWFGLVNDAAGTEDIAARVRAGGPGVAPLPDVLDLYAFTPPRRAASSPPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CX61</accession>
    <name>A0A1H6CX61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_111237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77016">
        <property type="protein sequence ID" value="SEG77016"/>
        <property type="gene ID" value="SAMN04489712_111237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG77016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="180" mass="20702" checksum="B8F76E26A61815E4" modified="2017-01-18" version="1">MSRAARHEEFRQYVSARGPVLLRSAMQLTGDRTEAEDLLQVALAKTYLAWDRINDRSAVDGYVRRAMVNTQISWWRRRKLDIYPTDVLPDQPVDDHTRRSEMRDALSRALDRLPKRQRLAVMLRYYEDMSEAEIAEVLGVSVGTVKSTVSRAMAKLRDDTDLGNDFTASPEVIDTTDRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D276</accession>
    <name>A0A1H6D276_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78875">
        <property type="protein sequence ID" value="SEG78875"/>
        <property type="gene ID" value="SAMN04489712_112136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG78875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="61" mass="6789" checksum="265497DD24437956" modified="2017-01-18" version="1">MNRLIDPRGMDRAGVVAAAAVVGFFGNEWVARHRIRSGRRIGSARRRRADSPRVLAHHLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4M0</accession>
    <name>A0A1H6D4M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cholesterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80309">
        <property type="protein sequence ID" value="SEG80309"/>
        <property type="gene ID" value="SAMN04489712_11359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="6">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="5">
        <location>
            <begin position="211"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="7">
        <location>
            <begin position="505"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG80309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="796" mass="85297" checksum="ABA4F837D954BB62" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4M9</accession>
    <name>A0A1H6D4M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80319">
        <property type="protein sequence ID" value="SEG80319"/>
        <property type="gene ID" value="SAMN04489712_11361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="24543" checksum="737B0D0462307121" modified="2017-01-18" version="1">MPVRTEPHSGRDLALPALREVYRAYVRAAGGLPALPDPLRAELWTSTQLGALESAAPHAAGHRLAMGDLIAELHRAAAPGTRAFLLGIAAIGPQWARRAAGKAAAALRDLPAPPWADALGQVTPGPAWLIQEGPLDGDRLVLEFRYGPEHTGPHHALAVRLMQDSPTEIVVVGDVAAMMADARKAVQAELCTVQPVAQGAAAGRLRAALDTGTPPPEDCYPALALARHRAAVIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6N1</accession>
    <name>A0A1H6D6N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_113144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80744">
        <property type="protein sequence ID" value="SEG80744"/>
        <property type="gene ID" value="SAMN04489712_113144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="18780" checksum="FF7DECF95EC93355" modified="2017-01-18" version="1">MSHQVADAVAEIAAPLEELLAGCDHVVSIYLCGVTEAGEPSRAPVELAGALYTASGIPLCPAVAERVGRPWRDRLHQLVHAQIPTVRSWPPKDPPELELSADEIERVTALTDDLAEVLEAHLGPVRRAYELSSHGGSYREIPPDMCCSHDIVWNDLLLVTKAWATLLHIGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D837</accession>
    <name>A0A1H6D837_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81244">
        <property type="protein sequence ID" value="SEG81244"/>
        <property type="gene ID" value="SAMN04489712_1146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="59"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="27245" checksum="72CEEADCD072174F" modified="2017-01-18" version="1">MATEERTFSQEDYDFDALYAGRARFEGSDPDANFIPWDIGEPQPVIVELEQAGGFRGKVLDVGCGLGENAILLAGNGHEVTGVDGSPSAIEQAGRRASEQGVRVRFLVADATELRDIGTGFDTVLDSGLYHCLNGEQRSAYTAALHRVCRPGAVLHLFCFAESVPSGTPIAEEALVSTDDLHANLDRHWRIEDIADTVFATGFTRELLAKMQQTGTAAGGTETAGAPPLDALRVDERGRVLTPMHHVRARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D838</accession>
    <name>A0A1H6D838_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_113178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80925">
        <property type="protein sequence ID" value="SEG80925"/>
        <property type="gene ID" value="SAMN04489712_113178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG80925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="27042" checksum="2473817E96165FD3" modified="2017-01-18" version="1">MTWFRCAETRPWASLRLFCFPHAGGSAVAYRSWGKELSAAVEVHAVQYPGRADRLAEPLVGDAHRLARLVAGAMAPMMDRPAALFGHSMGAIVAYETARLLEERGAPPTHLFASGARPPHRRDVDAEGRVADRDDDGVVAALAELGGSDAEVLADPEMRELVLPYVRNDFRLIEDYQRRPGPNPAVPVTALIGDSDPHVDEVRAREWAEATDGPFTLKVLPGDHFYLVPRQSEVLREIERALHVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D885</accession>
    <name>A0A1H6D885_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81308">
        <property type="protein sequence ID" value="SEG81308"/>
        <property type="gene ID" value="SAMN04489712_11422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="121" mass="13590" checksum="557C2DFDBADDAE26" modified="2017-01-18" version="1">MLIGELSRRTGVSPRLLRYYEEQGLLAAGRGPNGYRHYDDDSVITVRKIRVLLDAGLSTEVIRSVLPCTRDDQPEFDWCADIRDLLDRELAALDARIKSLQRDRGTLAGFLAQPGGHPQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D980</accession>
    <name>A0A1H6D980_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81901">
        <property type="protein sequence ID" value="SEG81901"/>
        <property type="gene ID" value="SAMN04489712_114169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="40"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="30648" checksum="DBB6988B6E00532D" modified="2017-01-18" version="1">MEMVLRTHRALLSRLLPDVEPEDVTVHEGQFHLVVIGSGRVVCLPRTEAAAARLPRRAAVLRSLAGFDLGFRTPEPLVEGGVDGVGEPSFLMLSRVPGTPLTADVLDDPQVADAVAGQYVGLLTGLARAGADDRVRAALPAPEDRWRRFATDVRAELFGLMSADGRRRAERELAALENLPHLTAAVVHGDLGAENVLWESADGLPRLSGVIDWDEVTLGDPAEDLAAIGAGYGEGLLRRVLILGGWADHETRTRIAAIGGTFALQQALAAHRDGDEEELADGLAGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9M0</accession>
    <name>A0A1H6D9M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_114182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81970">
        <property type="protein sequence ID" value="SEG81970"/>
        <property type="gene ID" value="SAMN04489712_114182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG81970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="42268" checksum="07A9B56B09CF813B" modified="2017-01-18" version="1">MKALCWEGVDKLDVQRVPDPQIVNDQDAIVKVTLSTTCGSDLHLINGFVPTMRPGDVMGHEFMGEIVEAGPGVRHRRVGDRVVVCSFIGCGRCWYCTHDQWSLCDNSNPNWELAQEVFGFELGGVYAYSHALGGFKGSHAEYIRVPFADYGTFLVPDDVDDLDALFASDAAPTGWMGADLGGVQPGDVVAVWGAGGVGQMAARAAELLGAEQVIVIDRLPERLAMTERHTGAETIDFSTTDVDAELRERTGGRGPDVCIEAVGMEAVGGNGQHAAEKIRRRLGRPQERPIALRQAIHACRKGGSVFILGVFGGSVDRFPLGAVMNKGMTVRGAQQHGHRYIPMLLERIAAGELSTSHLATHEFSLEGAPKGYQMFKNKQDGCVRAVFRPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCQ9</accession>
    <name>A0A1H6DCQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_115140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83080">
        <property type="protein sequence ID" value="SEG83080"/>
        <property type="gene ID" value="SAMN04489712_115140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="116"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="577" mass="62435" checksum="A2EDBF358D0E8B69" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCV3</accession>
    <name>A0A1H6DCV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82535">
        <property type="protein sequence ID" value="SEG82535"/>
        <property type="gene ID" value="SAMN04489712_11540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12971" checksum="D5C7AE87213E4433" modified="2017-01-18" version="1">MKHYLLSLYQPDGESPSPELLQQVMRNLDALNEEIRAAGAWVFAAGLHHPSTATVLRHQGDEVLMTDGPFVEGKEYLGGFTIVRAPDLDAALEWGRRLSRATTLPVEVRPFQGDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDY6</accession>
    <name>A0A1H6DDY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83489">
        <property type="protein sequence ID" value="SEG83489"/>
        <property type="gene ID" value="SAMN04489712_1164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="22269" checksum="926BCCCAC86DA1DF" modified="2017-01-18" version="1">MVIVEAVVETYGKEEFTAWPVAGPVADGLLPLSGRMTAAEVGTVMAVIAVGSAYFAEEEIADTDGAGLLRHLARADDVIAPGGLRFRDNDIVVPPGCCYGLESWRDWLDLPSEPWLGHNPTPGLRHQDGLLRLWPDKDRAPDPPPEATIQFPTGQLPGLLAAVQHDLGGFLSLVARWAQIHTPASADRLVTVLDEQLQITAPLTVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE62</accession>
    <name>A0A1H6DE62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83514">
        <property type="protein sequence ID" value="SEG83514"/>
        <property type="gene ID" value="SAMN04489712_11610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="24136" checksum="DE0D37EBFBE67349" modified="2017-01-18" version="1">MVGARAEWRPEGADRNAVVYDADGNVLAEETLGDGIEHVFATRTGHIWVGYFDEGVYGNYGWDGPGPPALGACGLARFSPSLQPNWRFPQSGRWGAISDCYALNIDGDTAWTCYYTDFPIVRIQDGALTGWRNDIHGAKALAVGGSRLALYGGYGADRNRLAVGDLGDEALRVTGEYRVVLPDGQPLPADTQVIGRGPDLHFLTDDNWYRLGLDDIPTKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE97</accession>
    <name>A0A1H6DE97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized membrane protein YcaP, DUF421 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83554">
        <property type="protein sequence ID" value="SEG83554"/>
        <property type="gene ID" value="SAMN04489712_11621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG83554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="20583" checksum="9222118797885F55" modified="2017-01-18" version="1">MWWLTGEWASLGAVVGKAALIYLAALLVLRLSQRRTLAEWTIPDFVTAVAVGAVVGRTAIASTQSFVTGVVALVTFVVLHRVINLARFKPVFGRLLEHQVRVLVAHGRIREDQLRLCGLTTGDLFAHLRQRGVFELSGIRYVLYETTGGLTVVPEEDDAGPVPELVRAGLRESRDFPERTPDRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEH5</accession>
    <name>A0A1H6DEH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83482">
        <property type="protein sequence ID" value="SEG83482"/>
        <property type="gene ID" value="SAMN04489712_1162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="71" mass="7689" checksum="0F3AC32923ACD670" modified="2017-01-18" version="1">MCRSESFQSCRGLPDGAVLVRATEHLDQYRGDAVRRNFEALAPALPVGMPRAGEVAGRRLVEADAADFQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEJ4</accession>
    <name>A0A1H6DEJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83644">
        <property type="protein sequence ID" value="SEG83644"/>
        <property type="gene ID" value="SAMN04489712_11641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295819" evidence="1">
        <location>
            <begin position="24"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="389" mass="40483" checksum="CAE7D429979D05ED" modified="2017-01-18" version="1">MRFLLTTMSAPSHLMPLIPFAHAAQAAGHQVLVATCGPALRTATSAGLVATEAGAGNDPVTPYEDLVRRLNQERLGVGRSEQEMYALHGEVFGEIGARMLDDLVETIGTWGADAVVYPGIHAAALVAARIAGVPAVLHGYGTPLPTFSPALDYLEPHARKAGVDSVREAEVEIDVLPPSLTNFTEVAPRGGRPQHTLPMRYGAYNGGGLLPLWAMRRGERPRVVATCGSLAAMSQDGAVYREIVRGTAGLGVELVVLTAGAELSALPDPLPGHVRLVDWMPLERLLASCDAIVHHGGSGTVLSSFAAGAPQVAVPLPGTVNVTNAQTMTARGAGRTLDMDALTADTVAEAVAEVLRDATRRRAAAEVAAEIAGLPTAAETVGRVHELIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEK5</accession>
    <name>A0A1H6DEK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted nucleic acid-binding protein, contains Zn-ribbon domain (Includes truncated derivatives)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_115157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83153">
        <property type="protein sequence ID" value="SEG83153"/>
        <property type="gene ID" value="SAMN04489712_115157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="18398" checksum="DBD4CBE2775FC5F5" modified="2017-01-18" version="1">MNADSGDDPQAVHDSAPASGKSGIELAREALAQARADALKRGTVPGQGRRKGGGRPKPVRDPGRGGDPKPFGAAIRELLAARGWEQRAAVGGVFGNWPGIVGPELARHTRPERFEDGELTVVADSNAWAQQVRLLASQLVRRLNEELGHGTVRRVKVVGPASGPRRTGGWRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGH5</accession>
    <name>A0A1H6DGH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83706">
        <property type="protein sequence ID" value="SEG83706"/>
        <property type="gene ID" value="SAMN04489712_11652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="26"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="25694" checksum="34076D56B5FDF23C" modified="2017-01-18" version="1">MASELHVDAHAVGLTVRPPEGSGIVLLHLHGDRHLSGEPEPGLDLAGHLAVRTGAEVVCARYRPRFPVALADVRAAYEHCRAAGPVIVVGTLAGAGLATALLLQLRDEGARLPECAVLVSALLDLRLEAQSLLFNAAANPAFDVAELRRRVAEYACGAPRTDPLLSPLLGNLHGLPPVQVQTAGTDPLLDDSLAFAARAAHSGMNVNLHIRQDAAELRARIVPAAAAFIGSWAPSAAVRAPWPPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJ33</accession>
    <name>A0A1H6DJ33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_117157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85181">
        <property type="protein sequence ID" value="SEG85181"/>
        <property type="gene ID" value="SAMN04489712_117157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="117"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="27537" checksum="01E0F419F7290BBE" modified="2017-01-18" version="1">MIDAADLALLSEGLRSAMAEARSAAGLDAALAELGWRELLEESPDEAVALVFGLLGETGAHAPVLNDVLLHAMKRPLGGVVALREDGLAFGRPGEPSPADLDPALGLCRVAWEPLTDEALAAGRRALGLQIVGAGRTMLALAREHALARTQFGRPVAAFQAVRHRLAETLVALEGAQAALEHATDPMTAKLGKALAGRAGLTAMRHCQQVLAGIGFTAEHRFHLFARRVLVLDDLLGSASALTREIGESLEASRIVPRLVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJZ7</accession>
    <name>A0A1H6DJZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske [2Fe-2S] domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_117152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85163">
        <property type="protein sequence ID" value="SEG85163"/>
        <property type="gene ID" value="SAMN04489712_117152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="47"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG85163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="421" mass="48143" checksum="94A6D2165383CE75" modified="2017-01-18" version="1">MPHFSKPAAGSWTEHYPELGTRPVDYTDSIDPACYAAEQTAIFKKTWLNVGRVEQLPKTGSYFTKELAVADTSLVLVRGKDKRIRAFHNLCRHRGNKLVWNDYPGEEVKGTCRQFTCKYHAWRYDLEGNLTFVQQEKEFFDLDKADFGLKSVRCEVWEGFIFVNLDPDAAPLSQYLGELGKGLEGYPFHEMTEVFTYKAEVGSNWKLFIDAFAEFYHAPVLHQKQATKEEAEKLLGYGFEALHYDIRSPHSMISSWGGMSPPKDPSMVKPIERVLRSGLFGPWDRPDIEGLDPLPPGVNPAGHRAWGVDSFHFFPNFMLLIWAPGWYLTYHYWPTAVDRHIFEANLYFVPAKTARERLAHELAAVTFKEYALQDANTLEATQTMLKSRAVTEFPLNDQEILLRHLHKVAGDYVKEHADAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DK59</accession>
    <name>A0A1H6DK59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85642">
        <property type="protein sequence ID" value="SEG85642"/>
        <property type="gene ID" value="SAMN04489712_11851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG85642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="353" mass="37631" checksum="75DC948E34F57424" modified="2017-01-18" version="1">METTEEKGAAAMSERTAELAIETSQLVKTFGDNRAVDGIDLAVPTGAVYGVLGPNGAGKTTTVRMLATLLRPDGGQARVFGHDVLREPNAVRSRVSLTGQYASVDEDLTGAENLVLLARLLGHRKPAARDRAAALLAAFGLEEAADRQVKNYSGGMRRRLDIAASILNTPDLLFLDEPTTGLDPRSRSQVWDIVRAVVAHGTTVLLTTQYMEEADRLAGRIAVIDHGKVIAEGTPGELKSSVGAGAVHVRLREAWQREQARQVLARTLDAQVQLDADPVALTARIMDGGTRDRAAAQASRALAELDEAGITVDDFSLGQPSLDEVFLALTGHPAEQADDSEQDGERESVEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQB9</accession>
    <name>A0A1H6DQB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4328 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_120132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87441">
        <property type="protein sequence ID" value="SEG87441"/>
        <property type="gene ID" value="SAMN04489712_120132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025565">
        <property type="entry name" value="DUF4328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14219">
        <property type="entry name" value="DUF4328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4328" evidence="2">
        <location>
            <begin position="65"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="25919" checksum="4C35E3785B028894" modified="2017-01-18" version="1">MQPSPQQVQAGTTGHADEGPVRPAWRLGALTMAMLGVWTVVALASMVVLGLHVRRLDDAAQSGGPSVLEVSDALPRLALLAQAVAVLCTAVLFVLWLRRAYDNAERIMHLPQRFGRPWVTYGWIIPVAHLWAPKLIVDDVWAASTGRASGHDRRWVTAWWVCWLVYLVGGNFALSLDDDGDLAAERTQAIVSILLIVPGLAAAALAATLIWKINTTQQAQGDRMAAATATTTPPSAPRPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DR55</accession>
    <name>A0A1H6DR55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87173">
        <property type="protein sequence ID" value="SEG87173"/>
        <property type="gene ID" value="SAMN04489712_12082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="77" mass="8257" checksum="E3956045CB9AC848" modified="2017-01-18" version="1">MVQAYILIQTEVGRAADVAHEISGITGVTQAEDVTGPYDVIVRAEARNVDELGKLVVAQIQTVEGITRTLTCPIVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DW72</accession>
    <name>A0A1H6DW72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89600">
        <property type="protein sequence ID" value="SEG89600"/>
        <property type="gene ID" value="SAMN04489712_1241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="25" mass="2696" checksum="04BBC4376B46B33E" modified="2017-01-18" version="1" fragment="single">DARNSYWNNITPDPADHDPAAGQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX99</accession>
    <name>A0A1H6DX99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89205">
        <property type="protein sequence ID" value="SEG89205"/>
        <property type="gene ID" value="SAMN04489712_12341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="7">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG89205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="31597" checksum="1ADA01BF93E039A1" modified="2017-01-18" version="1">MRALGRWWYPPVPRARIAWLRILAYGFLPFDMLLLTNSTLAHAHLPPSLYQPVLLARLVHLPAPTPGAMYALLAVTLAAAALAAAGRLPRAAGLVAALGYLWWVTISMSYGKVDHDHLALVVALFVLPTAGRARIGDREGCEASGWAARCVQIAVVAAYFLSAWAKMRIGGPGWPNGATLQWALNRRGTPPGRLLTDYPGLLRAGQWVTLVAEFASPLLLVARGRWLLLGVAFFAGFHVVTYALMTIHFLPHAIWLAAFLPLERLPWPRRAPGDREREETRDGLVAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXI0</accession>
    <name>A0A1H6DXI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulatory protein, FmdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG89981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89981">
        <property type="protein sequence ID" value="SEG89981"/>
        <property type="gene ID" value="SAMN04489712_1255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="92" mass="10001" checksum="CC23FF4CE5514ECA" modified="2017-01-18" version="1">MTYGYRCAGCGPFDVALPMGRAGPERRCPHCGGTARRVFTAPSLTRPGHPLNRARDAQEASAHEPRVVTRVPEAPRRPAPAADPRHARLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXY5</accession>
    <name>A0A1H6DXY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90158">
        <property type="protein sequence ID" value="SEG90158"/>
        <property type="gene ID" value="SAMN04489712_12555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG90158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="477" mass="48566" checksum="3B775E4F1FB60C59" modified="2017-01-18" version="1">MSSKQSDDRLDPRLLVMIAVILLGGLLGILNSTMAAVATETLATTFDTSLSTVGWASTGFLLAVTATIPFTTWAVDRFGGRRLWLVGLALFLAGSLAAGLAWNVGSLIAFRTLQGVGAGLLDPLVLILLARAAGPQRAGRVMGLMGVVLSLGPALGPIAGGALLDGLSWRWMFLFSVPVGALAYLLALRVVPADAPTDTERPRLDVLGLALLAPGFTALVLALSQTAEHAAFTAWQAFLPLIVGVVLLIGYAVHALGSRRTPPLIDVRLFASRGFTASVTIMGLGGLANFATLFALPLYYQQAHGHGVLAAGLLMAPAGLGGAIAMPLAGGLSDRIGARGLAVGGALLAGLSALAFTRIGADTAEIWPVLAALAIGLGMGCFSAPTMGSLYRSLPGSMVAQGSSVLYMLNQLGAALGVALVTLILQTSGDPIAGFHGVFWLVAAAIAAVLAATRVLPGRPQTPAVHPQPVPSGKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZD0</accession>
    <name>A0A1H6DZD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90708">
        <property type="protein sequence ID" value="SEG90708"/>
        <property type="gene ID" value="SAMN04489712_12715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="405" mass="42238" checksum="3CF86B45374B0129" modified="2017-01-18" version="1">MALIALAADKGAPGVTTAAVALGAVWPRPVLVAECDQAGGDLVYRLPASDDDGRHTAMLNPSRGLLSLAATARRGLRPEQIGEHCQRLVGGLDVLVGITSAEQAQGMTWLWGPLGRAFAGLAPVDVLADCGRLGAGSPLLDLMREADMVVLLCRATLEQVAHLRERVTALAKELPGGPPIGIVVLADPRDFRGSIAEVDRIVAGSQLPATVLGGFALDPKGAEMLRGRWGGRLDRSLLIRSAREVAGNLVGRLAASPRGPQPADRLAGPFPDDGPAPSSGARNPWPPGVPHPSERRRTQQPDERQPDAPRQSPAQPGAQQEAGFRPEGLTRSASQPGAHPEADPWSGVSQPGASRPDAPRPAGLSRQEAPPPGVPQPDTARQSVPPPGADRAADPSRRGVPERGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZK9</accession>
    <name>A0A1H6DZK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propionyl-CoA carboxylase carboxyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90780">
        <property type="protein sequence ID" value="SEG90780"/>
        <property type="gene ID" value="SAMN04489712_12736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="287"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="533" mass="57405" checksum="54A4F55209C23250" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZL4</accession>
    <name>A0A1H6DZL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90095">
        <property type="protein sequence ID" value="SEG90095"/>
        <property type="gene ID" value="SAMN04489712_12537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG90095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="35669" checksum="27B7C9E83569EDC7" modified="2017-01-18" version="1">MRADRLVSLVLLLRQHGRLSATALARELEVSTRTVLRDIEALSAAGVPVYAERGRHGGFALLPGFRTELTGLNHDEALALLIAGSRRGAQAFGLGSALASAMLKVVDALPESHRDTAAGAARRLLIDPETDLLSRRLVAEEVPDAIVAEVRRAVLAGHRLRIHYAAAGQTPKWRTVDPIGLVTVRGQGYLLATRSGADRTYRLSRISAAEELAEPAQRPDRVDLDRAWKERSTRFRTGGDQVTVLVRVDPARREDLVGTALAVRAEDTDADGRLRLEVTFQDPRHAEWALWQLGTNAEALAPQWLRDSLRDRAAAIVASYESQPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2S1</accession>
    <name>A0A1H6E2S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, PucR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91493">
        <property type="protein sequence ID" value="SEG91493"/>
        <property type="gene ID" value="SAMN04489712_12935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="197"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="353"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG91493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="418" mass="46465" checksum="A84B44959223415F" modified="2017-01-18" version="1">MMCKRTAIDNFLTERDSVVGRAVVPNSAMTRSEIRAVMRNVATRLLDQVPQLADRLLVELRGTESPYRRIPEAVHRRDLEGAFRAGLGAVIQQWSERRDLTHAVENATRRAEQGIPLDSLLRGYRLATQITWEAMVDVVTAEYPEAAAAVLRGAGGMWHAVDRQAVVAADAYRRREAELRSRSAERAQALLDALLEGRADTAVVRDAAMALEVPQFGRYLVIATRPEPSDRADVHRRPAEAAGLRLLWRVRPDFDLVVVSLADRDPDRAIATLRPLLLGRAGVSPPVDGLLELSEARRYAVVALRTCRTGETVRLDERLPAALAVSQPDLAERLVEVVLRPILDLDPPDRDILLTTLSCWLDCDGSVTRTAAALYCHRNTVFNRVRRIETLTGRSPDHPRDAMELTLALDAYHITSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E341</accession>
    <name>A0A1H6E341_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ammonium transporter, Amt family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92098">
        <property type="protein sequence ID" value="SEG92098"/>
        <property type="gene ID" value="SAMN04489712_13222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9194" checksum="6884A815FD8EA9F3" modified="2017-01-18" version="1">MKYGLNIGDSAWVLVSFAMILLMTPGLALCYGGSISLLGKQIVAILAVGRYGCVLTYLIGKAVGVLFAFRPSVREEAAGLDTELRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8M8</accession>
    <name>A0A1H6E8M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93643">
        <property type="protein sequence ID" value="SEG93643"/>
        <property type="gene ID" value="SAMN04489712_1402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296659" evidence="1">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="8867" checksum="85747D1B51F0FC5D" modified="2017-01-18" version="1">MQSVACHLCGSCVLVKKNNLAHTEVQWTTDTNQCVELNEQADRGVQRGTVPTCLHLRDSIEASVRSGLVPVPDLDTRYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E978</accession>
    <name>A0A1H6E978_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93679">
        <property type="protein sequence ID" value="SEG93679"/>
        <property type="gene ID" value="SAMN04489712_14011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="27210" checksum="353EB452E601FF6F" modified="2017-01-18" version="1">MGITSVAQDGIRVITMDFPPVNALPVAGWRDLADAVEEAGRAPDTRAVVLRAEGRGFNAGVDIKELQRTPGFEALLGVNRGCYAAFKAIYECAVPVVAAVQGFCLGGGVGLVGNSDTIVASEDAYFGVPEVDRGALGAATHLARLVPVHLLRTLYYTSRTIPARQLLQYGSVLEVVPRDRLDDAAMTVAGEIAAKDTTVIRAAKEALNGIDPVDVHRSYRFEQGFTFELSLSGVADRHRDAFVATGRPLSGDQVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9A4</accession>
    <name>A0A1H6E9A4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_14520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94297">
        <property type="protein sequence ID" value="SEG94297"/>
        <property type="gene ID" value="SAMN04489712_14520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="4">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG94297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="15216" checksum="212281F50F114676" modified="2017-01-18" version="1">MASVPPYPGRNGRPGLPRVAAAVEHFLDSIQDPATRADYAQTLAHLIDLFPAWFPVVGLDCEHYEAVMSRWDDAAPATRNRHLSALTSFTNWAQQQNLLGSDPASPTPPPSTTPQTVTGTVDHSSPATTAVQGREEDRNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9P1</accession>
    <name>A0A1H6E9P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93829">
        <property type="protein sequence ID" value="SEG93829"/>
        <property type="gene ID" value="SAMN04489712_1412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="44"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="20347" checksum="295C5A1278E8E6A4" modified="2017-01-18" version="1">MHVSRLFRSEVGLSTLRIARPLYAVAAMAGRMRRSLQPYEFCVPAAADQVRTARRQVLSVLGPGHPCADSVSTVVSELVTNAVIHGSGAGDRVRVKVRLLRGSRVMVAVTDSGGGSGSGPRLRFGGAAETNGRGLFIVSALAEQWTVQSAGAGHRVRVVLAPGTDEGFCEGTKMVGDLATFPEFADLLSDVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S2M4</accession>
    <name>A0A1H5S2M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44862">
        <property type="protein sequence ID" value="SEF44862"/>
        <property type="gene ID" value="SAMN04489712_10156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03146">
        <property type="entry name" value="GAT1_Peptidase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF44862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="25932" checksum="D93B82AC5644225B" modified="2017-01-18" version="1">MGTDGQPHILAIGGGTFVPDDRYGLAPSPLLRYALDLTGQDRPRVCFLPTALGDGAEHVARGYAALSGLDVETSHLVLFPMPNIADMRSHLLSQDLLYVFGGSVANLLALWRLHGLDDILREAWQEGVVLAGQSAGALCWHVGGNTDSFGPLLRPLTDGLGFLPYSCGVHYDSDPQRRPLLQRLVGEGTLPAGYAADEGVGLHYVGTELVQAVSYRPEGRAYSVEPDGSGAAKETVIEPRMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SCW5</accession>
    <name>A0A1H5SCW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48244">
        <property type="protein sequence ID" value="SEF48244"/>
        <property type="gene ID" value="SAMN04489712_101154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16837">
        <property type="entry name" value="BldD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038099">
        <property type="entry name" value="BldD-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037664">
        <property type="entry name" value="BldD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF48244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="17922" checksum="429D50041E9603C4" modified="2017-01-18" version="1">MPSEYAKALGARLRAIRTQQGLSLHGVEEKSRGRWKAVVVGSYERGDRAVTVQKLAELADFYGVPVSELLPGGAAPSPLGPTPKLVIDLERLQQLPKDKAGPLARYAATIQSQRGDYNGKVLSIRQEDLRSLAVIYDKSPTELTEELIGWGVLDPEARRAVEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJB3</accession>
    <name>A0A1H5SJB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-succinyldiaminopimelate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50585">
        <property type="protein sequence ID" value="SEF50585"/>
        <property type="gene ID" value="SAMN04489712_101232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF50585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="379" mass="40794" checksum="EDF952AC69A65A21" modified="2017-01-18" version="1">MQGFGTTIFAEMTALAVRTGAINLGQGFPDSPGPEAMLERAVAAIRAGDNQYPPGPGVPELREAVARQRVERYGLGYDPDGEVLVTVGATEAIAAAILALAGPGDEVVVFEPYYDSYAAMIALAGAVRRPVTLRPEGGRFTFDPGELRAAVGPRTRLILVNSPHNPVGTVFTRAELEVIADVCREHDLTAVTDEVYEYLTFDGAGHVPLASLEGMRERTVAISSAGKTFSATGWKVGWITAPAPYVRAVQTVKQFLTYTASAPYQRAVAYALGHELGWVQGLRKSLEAKRDRLVAGLEAAGFTAYRPQGTYFVQADIRPLGFTDGMELARALPERAGVVAVPSQVFYDHAAAGAHFLRFAFCKRDHVIDEAVERLAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T4I7</accession>
    <name>A0A1H5T4I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding (PGRP) domain of peptidoglycan hydrolases-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57664">
        <property type="protein sequence ID" value="SEF57664"/>
        <property type="gene ID" value="SAMN04489712_101479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284614" evidence="1">
        <location>
            <begin position="30"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="126"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF57664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="20013" checksum="B08744D36D3B00CE" modified="2017-01-18" version="1">MNLKRMAITALATVGIMTTGAALAGPASADPEPYTGDPYTQALQLSWPVLKQGQTSEEVRTLQWLLNCHGKKVDVPSRFGPKTHAAVYAFQAELSDRPDGVVGTATWALLIGKGSIVYGGTDNDCVRALQVALNKWRYNDDLPITGYLGPRTKAKLHKFQSAHGLPATDQPDAKTWNKLIATPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TCW7</accession>
    <name>A0A1H5TCW7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60639">
        <property type="protein sequence ID" value="SEF60639"/>
        <property type="gene ID" value="SAMN04489712_101570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="7">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF60639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="14616" checksum="A3BF6724AB736386" modified="2017-01-18" version="1">MHWLGIVALLVGAILAFVVRGDLTPAGYLVMGAGAVLLAVGVWRLGRARRRTRAAGGPDTGYRTGTGKIAAMIAAAVYIVSPLDLVPDVFLPVGVVDDATAFGWLVFALGQEMARRSRGRRLSRGSSPRPGSSPPPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TP89</accession>
    <name>A0A1H5TP89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">katG</name>
        <name evidence="12" type="ORF">SAMN04489712_101677</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63911">
        <property type="protein sequence ID" value="SEF63911"/>
        <property type="gene ID" value="SAMN04489712_101677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="142"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)" evidence="8">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF63911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="743" mass="80909" checksum="9C38E679EE59843D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UVU3</accession>
    <name>A0A1H5UVU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv2161c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79189">
        <property type="protein sequence ID" value="SEF79189"/>
        <property type="gene ID" value="SAMN04489712_10255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF79189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="30285" checksum="3013CB92C2EA7267" modified="2017-01-18" version="1">MEFGISTFVTDEGIGPAALGRALEERGFASLFVAEHTHIPVDRQTPYPGGGELPRWYYRTFDPFVTLTAAATVTERLRVGTGIALVIQRDPFLLAKEVASLDRISGGRAIMGVGGGWLREEIRNHGTDPRTRMALLRERVLAVKELWTEDEAEFHGEFVNFDPVRSYPKPVQRPHPPVLIGGSGPTTFDRVVEFGDGWMPIYGRNTANLATQIAELRERAGRRLPVYVFGVPPKQEAVAELSAAGVDQVLFNLPTEPEEPTLTRLDKIAKLISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UXH3</accession>
    <name>A0A1H5UXH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_10276</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79726">
        <property type="protein sequence ID" value="SEF79726"/>
        <property type="gene ID" value="SAMN04489712_10276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
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        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
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        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="11">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF79726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="866" mass="95614" checksum="AB29F1D7EDC98EDD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V0F9</accession>
    <name>A0A1H5V0F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79967">
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        <property type="gene ID" value="SAMN04489712_10285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF79967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="702" mass="77306" checksum="2BF0006E6955E3E5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V0W8</accession>
    <name>A0A1H5V0W8_9ACTN</name>
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        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
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    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10296</name>
    </gene>
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        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80318">
        <property type="protein sequence ID" value="SEF80318"/>
        <property type="gene ID" value="SAMN04489712_10296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF80318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="492" mass="50608" checksum="64D79184F6BFF6C3" modified="2017-01-18" version="1">MPSLPLEADDPREIGRYRLTGRLGEGGQGVVYLGEAPDGQRVAVKVLKATSEAARARFAREMEAAQRVAPFCTAAVLESSATGRRPYVVSEFVEGPSLLQRVRERGPLHGGDLDRLMVNTASALTAIHGAGIVHRDLKPANVLLGPDGPRVVDFGIARAVDAETHTQMVGTPAYFAPEWLRGESPTPASDVFAWAGTMVFAATGRPPFGGGANIPALMHRIATEPPDLSGVPDRVRGLLAECLDKDPARRPTARTLLVRLADPSAGNQAPPTAGHPVGPAVPGPFTQPVWQHGPAGQDTVTGRPARGRGRTLALVAGTVVVTAVTVLAAVLLLLNGRGQGEDPGRNGTTTPPGSATSPGSTAPSDSGATASPPAGQNGGGIPAAFGGTWKGRVAQPSVLGGESSTDVTITLSAGGSQGQADYPGWGCTNRLELSNTAGSTVEFNETVVKDDPSNNGICTGGRVKLTLEGDRLRYESPNILGNGVTTGTLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VIA8</accession>
    <name>A0A1H5VIA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA polymerase (Family 10)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="SAMN04489712_102336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="PTHR11276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF87069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="19827" checksum="F17261AB035106AB" modified="2017-01-18" version="1">MSDVGALAPGFQGAEIAAEAIARGGPARAVAAGRPSYAADRLTAMGQTNDDVAALLLEYADLFAMNGGDGIRVRSYKKAADSIAAYRGDLTAIDVRTLPDVGEAIAKKVEEALDRGTFRQLEDLRAKIPGGARSLLAIPGLGPKRALHLHTELGVDSPRALAAAIEQGRLDGLRGYGPKTRQALLDGIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VSI7</accession>
    <name>A0A1H5VSI7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89976">
        <property type="protein sequence ID" value="SEF89976"/>
        <property type="gene ID" value="SAMN04489712_102433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF89976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="21349" checksum="E47344A1CE6503B1" modified="2017-01-18" version="1">MTRIVLATRNAGKIAELRRILDGVEVVGLEEFPQAPDVPETESTFAGNALLKARAIAAHTGLPAVADDSGLCVDALNGMPGVLSARWSGRLGSATGDKDRANLELVLDQIADVAPGLRGAHFACAAALVLPDGTERVVEGRMTGQLIDAPRGTGGFGYDPIFVPDGESRTSAELSPEEKDAISHRGKAFRVLAEILPEVLATGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VV67</accession>
    <name>A0A1H5VV67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase /ethylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90868">
        <property type="protein sequence ID" value="SEF90868"/>
        <property type="gene ID" value="SAMN04489712_102464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF90868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15896" checksum="1DE804C317C56808" modified="2017-01-18" version="1">MLTRIDHIGIACRDLDATVEFYRRTYGFTDIHTEVNEEQGVREAMLKINDAGDGGATYLQLLEPIRDDSPIAKFLAKNGEGVHHIAFGTDGDVQEEADGIASHGVRVLYDAPRRGSMGSRITFLHPKDCGGVLTELVQAAETTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W0V1</accession>
    <name>A0A1H5W0V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate or tyrosine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93125">
        <property type="protein sequence ID" value="SEF93125"/>
        <property type="gene ID" value="SAMN04489712_102548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF93125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="484" mass="49765" checksum="4F4879293B795704" modified="2017-01-18" version="1">MLPENGRPAADVLAEIDRLTEADLPVRGGKVTAYVYDTGLPEVHETAARAYLRMLEVNGLDPTAFPSIVELERQVVGAVAQRLGGDAATPGIFTSGGTESIMLAVKAARDARPVEGGRPQLVVPVTAHPAFHKAAHYLGLEPVAVPVDPATFRADPAAAAAAITDRTVLVVVSAPSYPQGVVDPVAEIAAAAAARGVPCHVDACVGGWLLPWMREAGAAVPPFDLSVPGVTSLSCDLHKYGYAPKGASVLLFADEAMRRRAYFASADWPGYTVINATVQSSKGAGPLGGAWATMQALGASGYRALAADALRATRRLIDGVASIPGLRVLGSPDAALVAVAAEPPLDVFVLSDEARRRGWFIQPQLSYAGIPANVHLTLTGVSLAGVDELLKVLAESAGAARAAGAPQVPDGLVEALLALDLDTVDDAGFAGLLASVGVSLNGGGQPDMAVVNTVLDALPPRTREALLVRFLSVLYRPSSTGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W5I1</accession>
    <name>A0A1H5W5I1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_102596</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94752">
        <property type="protein sequence ID" value="SEF94752"/>
        <property type="gene ID" value="SAMN04489712_102596"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="11">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF94752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="17889" checksum="BD7B67B1A484F971" modified="2017-01-18" version="1">MAPYLIMTLRATVAGTFLISMVGKLRGRETLAGFVMTVRRIGRVPDRFAAPVAAGVIVTEAGIVVLLAVPGGQVAGFAMAAAVLAGFAVVLMAALRRGLAEPCRCFGKAEEPIGRRHVVRNGVLFVAAAAGAVFAPGVEGVPLEPAAVLLCLLAASAFVAFVVLLDDLLFLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WD76</accession>
    <name>A0A1H5WD76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96757">
        <property type="protein sequence ID" value="SEF96757"/>
        <property type="gene ID" value="SAMN04489712_102655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF96757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="198" mass="21598" checksum="F0F258607481E26B" modified="2017-01-18" version="1">MPRGTYLHLAEDEPVEERFQCAPGPGGWRYVGERSDGGRVDLTVDGRWRQIRVELTTVSWLIRGGLAGHDLLWVRHPAGPAPAAPAEHGVRAAGFLGDSAGFLVAVARWLRLEPGEDAPVRLVRVQGPSLATLTVDQHWRLAEIETYETETAPLPVERYEVTDLATGEVHTVHLAGDVVLQAPNLELTDLQSPPSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X440</accession>
    <name>A0A1H5X440_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06554">
        <property type="protein sequence ID" value="SEG06554"/>
        <property type="gene ID" value="SAMN04489712_10381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG06554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="216" mass="23727" checksum="4F23BE07649BDC2E" modified="2017-01-18" version="1">MSELFEPLLRPYDEKRRAELVAAYMAVEHAAGPVPEVRFPALREPALRRTVARMLELSGRTLIRTSPAHWISGYDDAVREALAGDPACVLPIADRAVLVLVLIHSVAIPRAEGLLTDDSWLSPYPAPLEELRRRSQLTISELEAALRRLRAAGLVGQVKAGADEASGGYVPGPQFHRLTEAARRRLQEELILAAGPDSPLAAAIRARRRGARKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XI51</accession>
    <name>A0A1H5XI51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_103261</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11293">
        <property type="protein sequence ID" value="SEG11293"/>
        <property type="gene ID" value="SAMN04489712_103261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05801">
        <property type="entry name" value="PGM_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="11">
        <location>
            <begin position="39"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="12">
        <location>
            <begin position="210"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="13">
        <location>
            <begin position="320"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="10">
        <location>
            <begin position="481"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG11293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="545" mass="57831" checksum="60CEE4D551AA0CD7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XRZ8</accession>
    <name>A0A1H5XRZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_103364</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14036">
        <property type="protein sequence ID" value="SEG14036"/>
        <property type="gene ID" value="SAMN04489712_103364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="150"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="11">
        <location>
            <begin position="502"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG14036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="929" mass="104046" checksum="6DC30D46EFB3C415" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XT23</accession>
    <name>A0A1H5XT23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14949">
        <property type="protein sequence ID" value="SEG14949"/>
        <property type="gene ID" value="SAMN04489712_103399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG14949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="146" mass="15438" checksum="75E419B779409535" modified="2017-01-18" version="1">MTDAELLRLVRTAFQVHDPPPESVPAAARAAFRLREPDAALAGLVRDGDDEALPALRGDGTRLLVFAGGGLTVEVEVTGGEQVYQIAGQLLPPAHARVRVRHTDGELDGRAGPAGQFVVDGVPAGLISLLFRLPDDSSVVTSWIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XWZ4</accession>
    <name>A0A1H5XWZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA domain (Dynein-related subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16284">
        <property type="protein sequence ID" value="SEG16284"/>
        <property type="gene ID" value="SAMN04489712_103450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="71"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG16284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="37586" checksum="03BB6761543051BA" modified="2017-01-18" version="1">MATTEPASAAQDETWFIYRGDGRPHDGLERLPEPPPWRRFDRSGTDRRRDRALSYRPDKNAVKMVNAAVYLRRPLLVTGRPGTGKSTLAYNVAYELGLEPVLYWPITSKSTLEQGLYRYDAIGRLHETSLRQAAAPAADAAAPDIGRFIRLGPLGTALLPRPRPRVLLIDELDKSDIDLPNDLLNVFEEGGFTIPELDRLPEEQPMVHVMTSDERARVPVERGQVRCTAFPIVIITSNGEREFPPAFLRRCIRLMIEPPTPEQLADIVEAHLGRQARERSGDIIQEFLDRQTRGDLATDQLLNAIYLATSGARPPQSDLEELREAILRPLDAAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XYC4</accession>
    <name>A0A1H5XYC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16632">
        <property type="protein sequence ID" value="SEG16632"/>
        <property type="gene ID" value="SAMN04489712_103466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG16632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="39099" checksum="0A7E17830B959CA9" modified="2017-01-18" version="1">MESLTWPQVLAWRMRRQYLHPTGTETAVQVARRLAGVQAQVASAAELAVAVRQAAPDPGETARALWQERTLVKTWAMRGTLHLLPADEAGAYLALCATVRNWEKASWQRNFGASPAELEALAEAATEALAGGACLTREELGAEIVERTRAPHLAEALTSGWGALLKPLAWWGVLCFGPSQGNRVTFCAPSRHVPGWGGLPPAEDAARTVIRAYFGAHGPATVEAFDAWLMRRTHRRKDVRAWFAAMADELVPVEVDGAPMYALAEHLDELIATGPADAVRLLGGFDQYVLGAGTGAAYLIPPGRRAEVSRAAGWISPVVLHRGRVAGIWDAKDGIDPTLWEDVPTALLEPEIARLTRLLGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XYF3</accession>
    <name>A0A1H5XYF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16698">
        <property type="protein sequence ID" value="SEG16698"/>
        <property type="gene ID" value="SAMN04489712_103469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG16698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="215" mass="23610" checksum="93490D0073C33BB1" modified="2017-01-18" version="1">MDAVVKRLLREAGQTYAEEAGIPLKDQPSALFKLLVLSNLLSARITAQIAVAAARELFEAGGGTARGLERMSWQERVDALGRGHYVRYDESTSTRLGGTAELAQRKYGGDLRRLARDSGRDPERAAEMLREFPGIGPTGVDIFFREAQAVWPWLRPYIDEQVRKGAERLGLPTDPKELAGLVPDKDVARLSAALVRVARDKKLADSIKNGGKDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y0H5</accession>
    <name>A0A1H5Y0H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_103487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17177">
        <property type="protein sequence ID" value="SEG17177"/>
        <property type="gene ID" value="SAMN04489712_103487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="67"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="165"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG17177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="24757" checksum="E0E8A629307E9F69" modified="2017-01-18" version="1">MVTASPRAPCIIYGMDGARERSSPVAEPSRGHPVPSGAPRADGTEEVDLEEALREALNGDETAFRALYRDIQPRLLRYLRALVGADADDVASDTWLQIARDLGTFRGDYDRFRGWSTRIARNRAIDHLRRAGRRPGVSLPVEEFPERAGARDTETDVLERLSTEAAIALIAELPRDQAEAVLLRVVVGLDAREAGRVLGKRAGSVRTSAYRGLRRLSEKLGERGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YJ10</accession>
    <name>A0A1H5YJ10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized peroxidase-related enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23692">
        <property type="protein sequence ID" value="SEG23692"/>
        <property type="gene ID" value="SAMN04489712_10424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010195">
        <property type="entry name" value="Uncharacterised_peroxidase-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01926">
        <property type="entry name" value="peroxid_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="93"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="189" mass="19807" checksum="F7BBD24C621AE41A" modified="2017-01-18" version="1">MAHIDLGEDLPGLPSLLRFRPETAGPLSALAETLLRGPSPLERGERELIASYVSTLNECRFCAWSHGACAAAQLDGGMSLVEQVHADPATAPVSDKLRALLRIAAAVQRGGREVTGGDVAAARAAGATDVEIHDTVLIAAAFCMYNRYVDGLATFTPTDPQAYTRMAERLTTHGYGAPPSNPPQGAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YRZ5</accession>
    <name>A0A1H5YRZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26921">
        <property type="protein sequence ID" value="SEG26921"/>
        <property type="gene ID" value="SAMN04489712_104155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG26921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="460" mass="50363" checksum="44092F56D384A5AD" modified="2017-01-18" version="1">MADSTFQPRTPLAQLMALVGWNGDRLARGLNAFAQAQGRPERLHPKTPYKWVRGETPRSPWRALTAALLSDALQRPVTTAELGWPEDDLQCVSAITGLQVPWTTSGTLRGLRTVTDAGPMDRRLFLMLLGAAATSPAHEWLIARQVGDTGRASGAPVPLEVADRLDQIAGHLRRMDDQLGGGQLLTLVHQHLRYVTGLLDERRYSDTVGRRLHATAAELLRLAGFICFDSGLHARAQRYWVTALHAAHTAGDRALGANILGFWSCQAKDIGQIREAITLAETARTGYPGASPKVSAILELRKAEAYANDHAATDTRRAIDTAFDTLTGAPASTGHPDWAYWMDEAHAHAQAGYCYLRLGDHSRARAHLRSGLRLQGAGYSREGALRRVLLATSYVQQEHPNLDAGLAQAHQALDTLTGEVDSARCLGHLSHLVDHLTPHRRSPEVREFIDRARPLMSPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YYB6</accession>
    <name>A0A1H5YYB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29223">
        <property type="protein sequence ID" value="SEG29223"/>
        <property type="gene ID" value="SAMN04489712_104258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG29223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="84" mass="9223" checksum="2FBE6E9FA11814CF" modified="2017-01-18" version="1">MRCRLRHRRDAVDPLSRLPAARVAPDPAFRAALRERLVSTAPCRSPGGPVRAPERRRRAFRRPGVFGGLMIAVVLLCAHLAACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YYH6</accession>
    <name>A0A1H5YYH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ORF">SAMN04489712_104213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28226">
        <property type="protein sequence ID" value="SEG28226"/>
        <property type="gene ID" value="SAMN04489712_104213"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
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        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
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        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG28226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="30503" checksum="2BA1CF6FC714E9A4" modified="2017-01-18" version="1">MTPVIARTREELAAARSGVTGTLALVPTMGALHEGHRSLIRRARELADTVAVSIFVNPLQFAPHEDLERYPRPFAADVEACAAEGVDLVWAPAVEVMYPADPEVRVSSGRMGTVVEGAARPGHFDGMLTVVLKLLNQVRPDVAVFGAKDAQQFALIRRMVADLDLPVRVVSGPTVREPDGLALSSRNRYLSDAERKTALSLSRALYAGEAAAGEGPAAVLRAARDVLDEAVEADPPLALDYLELVDPATFDPVGESHAGEAVLVVAGKVGTTHLIDNVPLAIEPRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z0W7</accession>
    <name>A0A1H5Z0W7_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29842">
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        <property type="gene ID" value="SAMN04489712_104284"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GG-red-SF"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG29842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="418" mass="45774" checksum="585309C0A6777E58" modified="2017-01-18" version="1">MTDSSGQADVIIVGAGPAGSSTAYWLAQAGLDVLLLEKATFPRDKICGDGLTPRAVRALISMGVDLGDPGWIRNKGLRIYGGGVKIELPWPELASFPDFGMARARTDLDRLLAEHAAKSGARLQQGCNVTGPILDERTGRILGVTARYQGEEVEYRAPLVVAADGNSSRLSLAMGLRKREDRPMGVAVRRYYHTPRHDDDYLESWLELWDGQRLLPGYGWVFPLGNGLSNVGLGLLNTSKAFQNVDYRAMLRGWTAGMPEEWQFDEDHATGPIRGAALPMGFNRQPHYTRGLLLVGDAGGMINPFNGEGIDYGMESGRLAAETIVQALARPTAAQRERALYEYPRILKDEHGGYFTIGRLFVKAIGDPKVMKFLTRHGLPHPTLMRFALKLMANLTDPRDGDAMDRIINAMSKVAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z139</accession>
    <name>A0A1H5Z139_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain-containing protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026414196.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29116">
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        <property type="gene ID" value="SAMN04489712_104253"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
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    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG29116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7490" checksum="89A898EAEEBBFEF2" modified="2017-01-18" version="1">MSSGERPLSEVRFLTVAEVAAVMRVSKMTVYRLVHSGELPAIRVGRSFRVPEQAVHDYLRDAFIEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z5K0</accession>
    <name>A0A1H5Z5K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized membrane protein YjjP, DUF1212 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_104367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31621">
        <property type="protein sequence ID" value="SEG31621"/>
        <property type="gene ID" value="SAMN04489712_104367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="6">
        <location>
            <begin position="41"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="7">
        <location>
            <begin position="307"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG31621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="460" mass="47526" checksum="1A687E5B167050E7" modified="2017-01-18" version="1">MGKIAWRLQRTWRTWTQGAAPDVPPEEDTEPGAAVSAEALDVVLRVGELLLTSGESTERVTEAMYGLAVAYELPRCEVQVSFTGLLVSVHPGHGFPPVTGSRAIRRRTPAYWRLPALHALVQDASIGMLEPAQAHQRLAEIKWARAPYPRWALVAALGLIAASASVLSGGGPVAAATAFGATVLGDRAAAVLARRGVAEFYQLAIAAAIATAAAALVVWVGTPARASAVVTGAILALLPGRPLVASIQDGITGDLVSAGARLLEVFFMIAAIVAGVGLVVYTAVRLHFPIDVSRLPSAPLTLEPVTVLAAAGVSAAFAISLAARRDVLLAVSLGGALIWTLFVLLRGQGVPPVVASAVAATVLGLLANALAVHRRVPVLPYVVPIIGPLLPGGLLFQGMVELNTGAPRHGLLSLIGALSVALALAAGVNLGGELVRAFRRIGLSASGRWARPAARRTRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z8Y4</accession>
    <name>A0A1H5Z8Y4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">SAMN04489712_104414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32534">
        <property type="protein sequence ID" value="SEG32534"/>
        <property type="gene ID" value="SAMN04489712_104414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG32534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="84" mass="9609" checksum="20B62012D638490B" modified="2017-01-18" version="1">MAKGLTADELRTEPEDQLVTKLKEAKEELFNLRFQAATGQLDNHGRLRQVKREIARIYTVMRERELGIVTVAEEPVAQEDENNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZGJ8</accession>
    <name>A0A1H5ZGJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35392">
        <property type="protein sequence ID" value="SEG35392"/>
        <property type="gene ID" value="SAMN04489712_104544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="295" mass="30680" checksum="6EC8635929BDC43A" modified="2017-01-18" version="1">MGPGLSSARLSSVQALRLRGGGTLARWRTAGRGYVWAVPYERPWRSWWPHLRRRRASWARRADRWSRAGGTSPAEGVPSRSASARRRAAGDDRSTETLSSSRESGSRESGEPPWPPPLPGRAEDDSAAAMGLAGSGVAVGWGRSTVAVGSGRSGVAVDEDSGDVAVGPGGAIGASEGGSGAGEGARSAVSRRCMSSRPMRAAKGATSAAMIGFTSSCRRSDAARRVRTEAPAAGLQPLVSMRRDSPCLGAGTRTAGTPSVSVSVVWADSRLVRPRDRAGESHDRPGHDPCCHSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZWU8</accession>
    <name>A0A1H5ZWU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="7" type="ORF">SAMN04489712_10559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40978">
        <property type="protein sequence ID" value="SEG40978"/>
        <property type="gene ID" value="SAMN04489712_10559"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="24"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="408"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG40978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="493" mass="51672" checksum="F24BC30CABD0663E" modified="2017-01-18" version="1">MTARLAVCAALGIEARALARGGLHVTRTGMGPRRTLAAAARLPTFDALAMAGFAGALDDRLRPGDLLVATEVRVGDRTLRCRSAELLASRLARGGGRVRLGPLVSTDHLVSGAERRALAATGALAVDMESGFLAAVSGTRPWAVVRAIVDTSDRPLLHPSTIGGALAARRRLREVGPALTDWAAALGPRRVLLPSPRSFCAGVERAIEVVERALDRYGAPVYVRKQIVHNTHVVDGLRRRGAVFVEELDEVPPGAVVVFSAHGVAPAVREQAGRAGLRVIDATCPLVAKVHAEARRLAARGDLVALIGHAGHEETEGTLGEAPDSTVLVETVEDVANLPAGRRVSYLMQTTLAADEAGRVADAIRRRFPDAQGPRSADICYATTNRQRAVCEVTGEADLVLVVGSANSSNSRRLVEVAEREGTPALLVDGPADIPLDRLAGVGTVGLTAGASAPPALVDAVVEALRGLGPVRVEERSVVTETVEFGLPKEVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADL1</accession>
    <name>A0A1H6ADL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fused isobutyryl-CoA mutase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Isobutyryl-CoA mutase</fullName>
                <shortName evidence="6">ICM</shortName>
                <ecNumber evidence="6">5.4.99.13</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">P-loop GTPase</fullName>
                <ecNumber evidence="6">3.6.5.-</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="6">G-protein chaperone</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">icmF</name>
        <name evidence="9" type="ORF">SAMN04489712_105365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-methylpropanoyl-CoA = butanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:13141"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="EC" id="5.4.99.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IcmF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.13" evidence="6"/>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46462">
        <property type="protein sequence ID" value="SEG46462"/>
        <property type="gene ID" value="SAMN04489712_105365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047727">
        <property type="term" value="F:isobutyryl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034784">
        <property type="term" value="F:pivalyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02050">
        <property type="entry name" value="IcmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033669">
        <property type="entry name" value="IcmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="5 6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="8">
        <location>
            <begin position="10"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="6">
        <location>
            <begin position="400"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="459"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="202"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="339"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="754"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="803"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="838"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="843"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="955"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1074"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG46462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1075" mass="117808" checksum="C2EE8D407DA65615" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADN8</accession>
    <name>A0A1H6ADN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46274">
        <property type="protein sequence ID" value="SEG46274"/>
        <property type="gene ID" value="SAMN04489712_105355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="32862" checksum="95BE6CF4593245F5" modified="2017-01-18" version="1">MTRVAAVDCGTNSVRLLIADIADGRLTDLERRMEIVRLGEGVDETGRLAPQALERTFTAMRAYAKLIDVHGAESTRVVATSATRDAANRADFVAGVVDIFGVQPEVVTGEEEAELSFLGATRELAELRPPRPYLVVDIGGGSTEFVLGSSHAQASRSVDIGCVRMTERHVRDTGGAPPSPERIAAAVADIDGALADVRRRVPVDEARTLVGLAGSVTTVAGMALGLTEYDPARIHLSRITASQVHEVTRDLLHMSHDERAAVGVMHPGRVDVIGMGALILDRIMREYGFGAVVVSEHDILDGIAWSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AFL5</accession>
    <name>A0A1H6AFL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47498">
        <property type="protein sequence ID" value="SEG47498"/>
        <property type="gene ID" value="SAMN04489712_105424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG47498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="532" mass="58303" checksum="556D8A70516E46DB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AH74</accession>
    <name>A0A1H6AH74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_105438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47742">
        <property type="protein sequence ID" value="SEG47742"/>
        <property type="gene ID" value="SAMN04489712_105438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG47742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="363" mass="37416" checksum="4D028C67DAD7AFCF" modified="2017-01-18" version="1">MTTEMTTESVPAPRYRGPHLVPAPATGLLISALAAAWLLASLLAISLGSVHLPLSSVWEVVGAHLTGRAETADPLHDQVVWDIRTPRVLLAALVGAGLSVAGVVFQALVRNPLADPYVLGVSSGASLGAVLVTAAGTAALGGLGGLGVTGAAFTTALLTVLVVYLLAQRGGRLLDSWLLLVGVAVGYLCAAATTYAQLQLDPSELQGVMFWLMGSVAGATWQQLGVPAAVIAVCLAYLMVQARALNALLAGEDTAAGLGVPVHAQRIALLVIGSLLTATMVSVAGGIGFVGLMVPHMARLIVGPDHRRLLPVAMLSGAVFLVLVDLAARTAHRPEELPVGVFTTGLGVPFFLWLLRRRSARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AHT5</accession>
    <name>A0A1H6AHT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47714">
        <property type="protein sequence ID" value="SEG47714"/>
        <property type="gene ID" value="SAMN04489712_105436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG47714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="21432" checksum="61B28F980B2F0630" modified="2017-01-18" version="1">MGLRSVVRWLRAAAFAASCAGLAAAGHLIGGGAVDPPTLLLGFLIIFVPGLLLTARERTLATILPAVALSQVVLHVLLTRSAAETAPAPFPDPAVAAPHHGGSPGLAMFLMHTVSVLVTAWWLEYGEARLCGLARQLALWVLRPLLLLIGYAAPGDPSRPSVWFWTRPRPVVAVLRHSVVGRGPPASGRPGTIRPPATALPVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJH8</accession>
    <name>A0A1H6AJH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH2:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48165">
        <property type="protein sequence ID" value="SEG48165"/>
        <property type="gene ID" value="SAMN04489712_105460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG48165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="34650" checksum="DB25D802C66A2453" modified="2017-01-18" version="1">MRAWLVETLGEPHEVLDLRDRPAPRPGAGEVVLDVAACSLNFPDVLLCRGAYQQRPDLPFTPGLEAAGTVLEVGPGVTGVAPGMRAIAIPQLPSGALAERIVVSAQHIYPIKDSLPLDLVSCLFGTYQTAHFALHRRARIEPGETLLVHAGAGGVGSAAIQLGVAAGARVIATAGSAEKVEICRRLGAEVAIDYNSEDFVSRTLEATDGRGADLIVDPVGGSVLSNSIKCTAWEGRVIVAGFAGGEIPSIAANRILMRNISLVGLHWGPYVQRDPELVRDTLTELLDLLDQGRIRPLVDRRPFEAAPEALEDLAHRRTSGKVVIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AL20</accession>
    <name>A0A1H6AL20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48930">
        <property type="protein sequence ID" value="SEG48930"/>
        <property type="gene ID" value="SAMN04489712_105505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG48930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="333" mass="36553" checksum="46799C71607A9A69" modified="2017-01-18" version="1">MDKTPKLVITSPADAVAVIPYLLGFHPDNSLVILCWNTQSNFAARLDLVDREHYSDLLMQVLGMVIRNAADAAILLGYGGKDLALPLLAEVKDALEDVLTVKEVLHVDGGRWRSLVCHNRDCCPEEGTPYDITTSKVAAQATYAGLVAYGSRQDKAATLTPVEGQDRVWMVAETERAEADLLREGSSSDLLVREGLPMVRSLIGQDRRLTDQEAARLSVVLTHLRVRDEAWIRIAGHDPMQQLRLWQDVTRRAVEAYAAAPAALLAYTAYLSGDGGLAQMALARCRQASPSYALAWLLQQCLDYAVPPKVIRERFSLTPEALAQAWGDSTEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AMG9</accession>
    <name>A0A1H6AMG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49380">
        <property type="protein sequence ID" value="SEG49380"/>
        <property type="gene ID" value="SAMN04489712_105529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="213"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG49380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="371" mass="39362" checksum="DF7E2DA582E1FCA9" modified="2017-01-18" version="1">MSDREALQEVVQQVLADAWPPLPEYGSQRSLPPVPGRLLSLAEELGWGDLEEDADGFTFTATVLEQLGSVLGPGELVTNLTVGPMLSTVAQGGIGSDRFAVSWTAPVWRRDADAPVLDGEGDQLEMTGSVPWVLGGAPDARLLTPADHEGRPVVLLVPVHAERTRLEQVSSSDPTRAFAHWSADAMPVAQTQVLARDDEAVALVAELKERVNLSLALDSLGVAKAALDLTLAYAKVREQFGAPIGSFQAVKHRSVDMFVHVQCAEVLLEEAVTRFGSGAAERCLRAKAAACEAAAEVTRSALQSHGAVGYTWEHPCHLLLRRAKLNQALGTPADEARRAVGASLTAALPKLPEGATAVDRLGSREGSNDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B0G6</accession>
    <name>A0A1H6B0G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54070">
        <property type="protein sequence ID" value="SEG54070"/>
        <property type="gene ID" value="SAMN04489712_106134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG54070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="373" mass="39765" checksum="8135C203318CFF31" modified="2017-01-18" version="1">MDSLNTRLAALRGGTSPVGFSARTIAGLNENPGCARRALLDASGADKDRIGARVGFPGRFGQSPFALARGRVFEEQIKANGAAQLLRLLREKLGLTIEEAAYLPLEDVGDNTGRELRARHTTAQLLRAAREGDDAGTLFDHPMLRLRVAGCTAYLEPDLVAFQVGGRFHVVEIKSFAVIDGQVDGEQVTAAARQAAVYVLALRELLADHGLDPETVSHEVLLVTPADFTNRPVVSLIDVRKQLAAVRRVLARMSRVETLLDALPEGVSFDLAPDDDGDPTRDPAELAAALHQIPARYRPGCRAHCELAAFCRDEARCADSLDVFGPAVGGMLGGVDTVCAALGLAEGTRAPAEDEAEIARALRHAETLRSGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B168</accession>
    <name>A0A1H6B168_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54549">
        <property type="protein sequence ID" value="SEG54549"/>
        <property type="gene ID" value="SAMN04489712_106164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="192"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG54549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="29783" checksum="B21A332CB20E79C9" modified="2017-01-18" version="1">MLRSWDPEEMAATVARDRAQSAFLVPTHAHALRALGEDALRRHDLSSLDTLYFNAAPFPSPLKEWVLDAFPRVGVHELYGSTEAGIITNCRPADARRKAGSVGPPWHLTEIRVVGDDGEPVAPGERGELFSRSPFLMNGYLNDDEATRACTTPDGFVTSGDIVVRDEDGFVSIVDRKKDMIISGGVNVAPREVEEVVAAFPGVAEVAVVGAPSERWGEQVTAFVVALPGHRVAPDALDAHCRQRLSGPKLPRSFVFVEALPRNASGKVLKRELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B1U2</accession>
    <name>A0A1H6B1U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 family transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54197">
        <property type="protein sequence ID" value="SEG54197"/>
        <property type="gene ID" value="SAMN04489712_106142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG54197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="29408" checksum="FF13AF65EA10AE11" modified="2017-01-18" version="1">MTAQLAGELRVTEPRARFRDLAAAEWIKLRSLRSTWIAYGVTALTVIAINVGTAYDTYNHWREQGAADRAAFVRDGIPLQEAFTINAAAIMALALGVLGALMIIGEYATGGIRTTFAAVPARRSVMAAKAVVLTVFTTVFGAFVVGISFGLTQAILGSRGVGVSIGHPGALRVVLASTLLAPVCALAGLALGTVIRQTAPTMVASALVVIVLPTIITDGRHWSAVVGHALPFQAWLRLVTVDPAPTRFPWTTGGAWTVYAVWTLAAAALAIIAVHRRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B387</accession>
    <name>A0A1H6B387_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55082">
        <property type="protein sequence ID" value="SEG55082"/>
        <property type="gene ID" value="SAMN04489712_106202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="561"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG55082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="920" mass="99173" checksum="F19918FAC2427D9F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BD82</accession>
    <name>A0A1H6BD82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58801">
        <property type="protein sequence ID" value="SEG58801"/>
        <property type="gene ID" value="SAMN04489712_10722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG58801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="301" mass="32507" checksum="C5AD5EBD67648FE4" modified="2017-01-18" version="1">MRVLVTGWPSFLNGEATAGDVLAMEAVQEALQGAGVPCDLAWSPVFRPSGPSLAEVEPGRYTHLVFACGPLIGEQVRRLHHRYAHCRRVAVGVSVIDPHDPAVLGFHAVLARDGSGEEPRLDLAAELPVPDVPVVGVALAPGQPEYGSRRRHEQVEDELTAWLNTRDCARVPIDTRLDLYDWRNASTAAQVEALIRRLDLVVTTRLHGMVLALKNGVPALAVDPIEGGAKVGAQARAWGWPALVTALPGKPALNLAELERQWEWCLAGRAAAAAWDLRTDSEPLLTEDLLDVLDLRADQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BI37</accession>
    <name>A0A1H6BI37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60408">
        <property type="protein sequence ID" value="SEG60408"/>
        <property type="gene ID" value="SAMN04489712_107129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG60408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="14837" checksum="2318AE3E8E9E9CA9" modified="2017-01-18" version="1">MGLWDLATRRLRDRFDTGDCGGVGALAFEPGGAVLATGGGDGTVRLWDLATHRQIGGPVGANMNESPFRIASALRWVRYGKGGRLVAGDFMGLVQEWDVARPADPAAAVCALVGRDLTRAERVRHLPEKARDLRVCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BMX1</accession>
    <name>A0A1H6BMX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid/amide ABC transporter substrate-binding protein, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62020">
        <property type="protein sequence ID" value="SEG62020"/>
        <property type="gene ID" value="SAMN04489712_107266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="32"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG62020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="42510" checksum="4BB0D8A7FBFC6C9B" modified="2017-01-18" version="1">MRRFVPFLAAAALALAGCGGSGGSGDSGDGAIKIGFIESLTGNYAPLGGEAKKTVDLAVEQINAAGGIKGRRIELITLDDRTAPDQGVLHFNRLRTEKVTAIIGSTFSNVGLAVEPLAEREKIPYISLAPADEQVDPIRRYTFVVPAISSTYAEAMLQYWQAHKITRVAVAYDTKSAYSKAGFAGMKRLAPKYGVQIVREEPYETTASDFSPIFTHVRGSDAQAMMAWASGAPGVTLAKQYPNSGLRLPLYMTGSQASKLWLEPVGPAAEGVYVQSAIGVVGEYLPDGKLKSAIKEMADPFRQKYGYDAPQFAQDGYSGVRLLAAAIEKAGTDRERIRDALETMTLVTPAGKYTYSATDHSGLRATDISMNQVKDGRLVPTDWSKRRLAETARAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BWL4</accession>
    <name>A0A1H6BWL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64566">
        <property type="protein sequence ID" value="SEG64566"/>
        <property type="gene ID" value="SAMN04489712_10835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="PTHR42721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294211" evidence="4">
        <location>
            <begin position="35"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="877"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG64566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="997" mass="106867" checksum="0E16C16F3D7D9305" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXT7</accession>
    <name>A0A1H6BXT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette, subfamily B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_108111</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65510">
        <property type="protein sequence ID" value="SEG65510"/>
        <property type="gene ID" value="SAMN04489712_108111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="48"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="388"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="422"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG65510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="643" mass="69090" checksum="ACB88CBA4455E4CD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BY14</accession>
    <name>A0A1H6BY14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65347">
        <property type="protein sequence ID" value="SEG65347"/>
        <property type="gene ID" value="SAMN04489712_10897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="179" mass="19569" checksum="FE19BC3821924A0F" modified="2017-01-18" version="1">MLLAIIAGCEIGFWIFLLAGLTARYLLRWRRTGAALLVCVPLVDLVLLVATVLDLRAGATADFTHGLAAAYIGFSVAFGHSMIRWADTRFAHRFAGGPPPPRPPKYGMARARHEWREFGKALVAWAISCALLLGAIVMVGDAERTEALAGWIGRLSMVLGIWALWPITYTLWPAKPKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1S4</accession>
    <name>A0A1H6C1S4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_108211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66647">
        <property type="protein sequence ID" value="SEG66647"/>
        <property type="gene ID" value="SAMN04489712_108211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG66647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="32940" checksum="23560B30B8288363" modified="2017-01-18" version="1">MTEPQPTGVPAQPEAPVGPAPSTGRIPHGPFRAGDQVQLTDPKGRVNTITLQPGKLYHSHKGAIPHDEIIGSPEGSVFRSTGGTEYLAFRPLLADFALRMPRGAAVVYPKDAAQIVAMADIFPGARVVEAGAGSGALSCFLLRAVGEHGLVSSYERREDFAEIARKNVETFFGGPHPAWRLTVGALEDALAETEVDRVVLDMLAPWECLEAVAKALIPGGLVCAYIATTTQMSRVVEALREHGSFAEPYAFETMVRSWHVDGLAVRPDHRMVGHTGFLVTARRLAAGVTPPLRRRRPAKGAHPAPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1T4</accession>
    <name>A0A1H6C1T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hemolysin, contains CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_108242</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66970">
        <property type="protein sequence ID" value="SEG66970"/>
        <property type="gene ID" value="SAMN04489712_108242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="3"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="225"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="285"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG66970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="460" mass="49576" checksum="18B66D19B4562F6B" modified="2017-01-18" version="1">MITALSLLLGVAVVLLITALTGYFVAQEFAYMAVDRSRLNARAADGDGSAGRALKVTRRTSFMLSGAQLGITVTGLLVGYVAEPMIGRALGDLIGVAGVPAGTGLAVGTLLALGFSTLVQMLFGELFPKNLAIARPEPVARWLARSTLLYLKAFGWLIRVFDQSSNLLLRLLRIEPVHDVEHSATERDLAHIVADSRRSGDLPPDLSIMLDRVLDFPRRDVEHAMIPRSRVDTVDRDDPIAEVRRAMSTGHSRYPVLDEEEHVVGVVHLDDVLTAADTAGPVSAIMRPATVLPTLMTLPAALDRLIERRAQLACVIDEFGGFAGILTLEDLAEELVGEITDEHDAAAGEPTATAAGNAWIIPGTFHIDEVERTIDHRLPEGDYETIAGLVIASHGALPEVGTGLDIELPADPADLARTDDPPRRFVHVEVLEVDNHVPSSIRLQVGRTDEPATDEGTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1U7</accession>
    <name>A0A1H6C1U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RecB family exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66625">
        <property type="protein sequence ID" value="SEG66625"/>
        <property type="gene ID" value="SAMN04489712_108209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG66625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="36080" checksum="54BC5856171816B6" modified="2017-01-18" version="1">MTTSDSPAGTAPRAAGPRDGTGGVTGALSPSRAGDFMTCPLLYRFRVIDQIPERPSPAAVRGTLVHAVLERLYDLPAAGRTVAAALDLLGPQWERLLAREPELATMFEPGPGDADGTDNANGAGGGSDPDADQGAWLERARQMVERYFTLEDPRRLEPAERELYVETVLDSGLKLRGYIDRVDIAPTGEIRIVDYKTGTAPRADFEARALFQMKFYALVMWRLHGTVPRMLQLMYLGNGEILRYVPDEADLRATERKVEALWQAIRRATETGEWRPRPGRLCDWCDHKQRCPEFGGTPPPLPAVPTPRRSPADLEPGPSPRDHSDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7N5</accession>
    <name>A0A1H6C7N5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbamoyltransferase</fullName>
            <ecNumber evidence="8">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_10916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68747">
        <property type="protein sequence ID" value="SEG68747"/>
        <property type="gene ID" value="SAMN04489712_10916"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="11">
        <location>
            <begin position="213"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG68747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="768" mass="83132" checksum="83600932CC80409A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCR2</accession>
    <name>A0A1H6CCR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_109192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70688">
        <property type="protein sequence ID" value="SEG70688"/>
        <property type="gene ID" value="SAMN04489712_109192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="179"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="240"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG70688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="449" mass="48796" checksum="06708774D9AD64C3" modified="2017-01-18" version="1">MRLRPRSIRARDTLVAAVISVLVLGALAVAADLIIRANTTARLLHETQLAGRRVSGAVRDGTLRPPIPDDAKGIILQVVGPDGRVRATTRADRGRPPVSDLRPTVAQRIHDYVECDMPGYDRCMLVEAIRATTAPDSVVIYAAQPMPVLLTSGLLELLLAAGVLLMSAPVAWTTWHIVGRTLRPVEAIRAQLSEITASDLSRRVPQPAGEDEIAELARTANDTLDRLEYSVSRQRQFASDASHELRTPIAGLRANLEDASMHPDDTDLQAVVHAALRDTVRLESIITDLLLLARIGTGGAAAQERIDFTDLVRTEVGRRTPPVAIRTLLQDRLTVRGVRMQLVRLLHNLLDNAERYAESVIEIAAGRVDGHLLLTITDDGVGIPEPDRERVFERFTRLDTARSRASGGTGLGLAIARDIANAHGGSLHVEDSPYGARFALRLPLAPDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CD72</accession>
    <name>A0A1H6CD72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70959">
        <property type="protein sequence ID" value="SEG70959"/>
        <property type="gene ID" value="SAMN04489712_109225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045713">
        <property type="entry name" value="DUF6069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19545">
        <property type="entry name" value="DUF6069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="15576" checksum="DBEE1C43ED8FB4AE" modified="2017-01-18" version="1">MTTVTAAQTVQTAPSQPARRRARLTAVGSAVLVNSVLYVAGRLAGVDFKLTAPGTVEPHQLILPEIIAFTLLFGLLGWGALAALERLTRRAHAIWAVLATTVLVVSFAPIWIEHATSSTRAMLVVLHLVVATALFPLLRQGPGVPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDI8</accession>
    <name>A0A1H6CDI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR C-terminal helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70705">
        <property type="protein sequence ID" value="SEG70705"/>
        <property type="gene ID" value="SAMN04489712_109194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="335"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="419" mass="45757" checksum="E881725CA0BED5BE" modified="2017-01-18" version="1">MAGDGSTGSDRPWTQVPRELADRMRPHLDAVADDMIAEIQARVREYDRPPDAPYSSALRTAVERVLHYFVERVADPDGEPESVTAFFHAIGRGEAGEGRSLDAMQAALRVGGMVAWRRIAADAVRLNVPPAALGAIGAALLAYQDELAAAAAAGHAQARAAVAGEMQRRRRRLLDMLLAEPPASPESIADQAAAAHWPVPRTVAAVALGRHHADARQPAFPPDVLADLNRPAPSLIIPDPDGPGRAKLIDRALAGCIAVVGPTVPVAEAGRSMEWARRTLALAERGVIDEPDGVIRSVEHMSTLILFQDEELLAALSRLRLAPLSHLRSSQQDRLAETLLAWLQSGRNANEVAMRLHVHPQTVRYRLRQLEDLFGDQLLDPDLRFDLEIVLRARHMTDRERIMPPARRTASGEVVTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CE87</accession>
    <name>A0A1H6CE87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_109245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71143">
        <property type="protein sequence ID" value="SEG71143"/>
        <property type="gene ID" value="SAMN04489712_109245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="199"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG71143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="32336" checksum="FD50F7351437BD35" modified="2017-01-18" version="1">MSERASKMFRRGSRPGATRLADAVEDLEHADGLDGAIRTISSAISRVLRPGPVKDLLHGVPVGHPAHPPLTDVSVGCWTSAAILDLLPGTERASRTLIIAGLVGAVPTVLTGWTDWSALHREQQRVGLVHASANGTAAVLYTASLAARRRGLTGAGRLLGFAGFAAVLTGAYLGGHLAFRQAAGANHADKVAHLVSLGWHDLCSVEDLPDGWPVQRRLGYITMFVLRQGEEIHVLADRCAHLGGPLHQGRIITDRDEETCVVCPWHGSTFRVADGSVVHGPATARQPSFETRVENGTLQVRPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIS0</accession>
    <name>A0A1H6CIS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation-control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72822">
        <property type="protein sequence ID" value="SEG72822"/>
        <property type="gene ID" value="SAMN04489712_11038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009776">
        <property type="entry name" value="Spore_0_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40053">
        <property type="entry name" value="PTHR40053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07070">
        <property type="entry name" value="Spo0M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG72822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="29059" checksum="82244B0A11C28EB9" modified="2017-01-18" version="1">MVFKKLMKAMGVGGPSVETTLHNPNTTPGGTITGDVHLLGGDHDSDIKYVSVALKTRVEVESGDSEYHSDLEYAKIRLTDAFELKAGARHTVPFSLQIPWEAPLTHMYGQPLHGTTVGVATELEVARAVDATDLDPIAVHPLPAQERILVAFANLGFRFRNADCEKGRIWGVHQELPFYQEIEFYPAPQYASGIKQLEVTFVSYPQSMEVVLELDKRGGVFTEGHDSFARFTVDYASVNNTNWEQQLEGYLNQAARRRGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNF7</accession>
    <name>A0A1H6CNF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multiple sugar transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74287">
        <property type="protein sequence ID" value="SEG74287"/>
        <property type="gene ID" value="SAMN04489712_110209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295061" evidence="1">
        <location>
            <begin position="26"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="462" mass="49810" checksum="8BB70A099BCAA317" modified="2017-01-18" version="1">MRLRHTAVLLAAALALSGTACGAKSSKKDDLGAAPGATAGPLDPNTKVSITVGCQPPKTAKAERAAWDSDVKEFQAKHPNITIVSKDAFPCIVPETFQAKLAGGQMEDVFYVYYTDAQNIIRNRQAADITPYVSGLQSVRDVNPQFLQALKGTDGRIYGLPRKGYTTGLVYNRKLFTQAGLDPNNPPKTWAEVREAAKKITALGPGYVGYGEYSAGNTGGWHFTSEIYGRGGDVVTPDGTKAAFNSPAGRAVLQNLKDMRWTDDSMGTKQLHRWEDLMRLMGSGKLGMMVGAPDVAVEVFLNFGAKIEDIGATTLPEARASLLGGDAYMINPKASPDQIKAAILWLEFRNLTPGQGQFDYEQFKSLGRPVGVPENLLWGTNASGTKERELRRRFATVPVDNFAPYENGAPSVAPKVEPPNAQAIYAILDSAMSAVLTRKDADIDQLLGDAEKKVNALLARTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRK7</accession>
    <name>A0A1H6CRK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Permease of the drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75397">
        <property type="protein sequence ID" value="SEG75397"/>
        <property type="gene ID" value="SAMN04489712_11132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="151"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG75397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="332" mass="34936" checksum="8679F384B3C426DB" modified="2017-01-18" version="1">MSRRGWVLFALMSVIWGIPYLMIKVAVEGVSAPVLVFARTAVGAAVLLPLALHAHGPRELRDLLRRYWLPMLLFSVVEILAPWLLLADAERVLTSSMTGLLIAVSPVVSVLIVRLTGGAERLGAWQWAGLAVGFGGVTVLAAPELGGGDTWSIMEVLLTACGYALGTLITARWLKDVPALPMTALCLTFAALVYTPPAVMTWPDAVPSGRVLAALAGLALICTALAFLVFFALIREVGPSRALVFTYVNPAVAVLAGVLLLGEPLTVTIVVSFVLILGGSILAMTRRPDPDTTDPQPEPRAAAPEAAISATATSEHVDSENGGSEAVDSETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSG6</accession>
    <name>A0A1H6CSG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75931">
        <property type="protein sequence ID" value="SEG75931"/>
        <property type="gene ID" value="SAMN04489712_11199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="542" mass="55811" checksum="7C85E0D74F98770A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSJ6</accession>
    <name>A0A1H6CSJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane secretion effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75990">
        <property type="protein sequence ID" value="SEG75990"/>
        <property type="gene ID" value="SAMN04489712_111106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="27362" checksum="4290CF686B3F24EF" modified="2017-01-18" version="1">MRRCGWALARLRAAGHRRTRSRVLLLNVLAGADGHLTVEAIHRRAAVSGRLDLSTVYRTLAVFERLQLVHTLEIGGRITYGLADHPHAHALAARRPPVRVVVLTGTVLTFLTMAWESTLVLLATGPMGVSDAGYGLMLAIGAIGGVLGAAVTPLLTRRFPQRALQIGALAATAAIDLTLALFPTPATAALAWGGTGFAFTVWNVLSVSLRQRLVPPDLLGRVNGANRAFSMTAVPAGALAGASSPTPSACTPRPGSAASPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTC4</accession>
    <name>A0A1H6CTC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76291">
        <property type="protein sequence ID" value="SEG76291"/>
        <property type="gene ID" value="SAMN04489712_111146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="88" mass="9801" checksum="37C15157D323E5CC" modified="2017-01-18" version="1">MTRMNIDIDEAALTELMELLETDDRDKAVNLAVQAAAVRVRLAKPAQRELAELFASGALDLEALEQPWRQRHSSQTPAHFTGSTESRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTV2</accession>
    <name>A0A1H6CTV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Release factor glutamine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76509">
        <property type="protein sequence ID" value="SEG76509"/>
        <property type="gene ID" value="SAMN04489712_111172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022446">
        <property type="entry name" value="CHP03704_MeTrfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03704">
        <property type="entry name" value="PrmC_rel_meth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="136"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="33737" checksum="C6557C3C040BC21A" modified="2017-01-18" version="1">MSVLPSPASHSAIVTRLRAAGCVFAEDEARLLIRTARTPADLDAMVDRRVASLPLEHVLGWAEFCGLRIAVDSGVFVPRRRTEFLIHQATALAHQATAPTGQGTAPTGQATAPTGQGVVRDGRAVGSGGQGSGSDRERVVVDLCCGSGALGVALAAALGRVELHAADIDPVAVRCARHNVAAVGGQVYEGDLYEPLPTALRGRIDILVANVPYVPTEAVGLLPPEARVHEARVALDGGADGLDVLRRVAAEAPRWLTPGGHLLFETSERQVPQAVAAIAGGGLAPRVVVSDELDATVVIATRPAAQSPLDSMTATTPARTTNSAPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUP5</accession>
    <name>A0A1H6CUP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76527">
        <property type="protein sequence ID" value="SEG76527"/>
        <property type="gene ID" value="SAMN04489712_111174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="56" mass="5813" checksum="A4AD70B5FE1256CE" modified="2017-01-18" version="1">MGGLLLKVAGIVLAIWLIASVAGAILSTVKFFFMIALLGAVVVLVVTLLAKSSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZ76</accession>
    <name>A0A1H6CZ76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78350">
        <property type="protein sequence ID" value="SEG78350"/>
        <property type="gene ID" value="SAMN04489712_11266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018719">
        <property type="entry name" value="DUF2243_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10002">
        <property type="entry name" value="DUF2243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="182" mass="20066" checksum="D19FFD8B0FF2C033" modified="2017-01-18" version="1">MVIGSETTAGRERRAARIGLPGILLGAGLGGFVDGILLHQILQWHHMLTSTDTARIGVRYYPANTVHGLQINTMWDGFFHAVTWLLVLTGLALLYSRVTHARGRLWTSRKLWGWVLVGWGLFNLIEGIVDHHVLGIHHVRTDAYQTWWDIGFLVLGALLVAGGWALQHGAAPVEIGAPETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6F1</accession>
    <name>A0A1H6D6F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Golgi phosphoprotein 3 (GPP34)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80862">
        <property type="protein sequence ID" value="SEG80862"/>
        <property type="gene ID" value="SAMN04489712_113166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="22731" checksum="2CB7A1329E083E56" modified="2017-01-18" version="1">MVKVPESLPARVFLLAYDMERGRLTARGRLGPLLRAAALTELYLDGRLVGDKKPEIGTPGDDPYGLLAQIGASRPRRWQYWVGKDGKAMVRAVRAELEAEGWIRVRSRRRLGLFPVQVVEVRDPRVVKDLWGRASSALRGKPVAHVNSYDAATMALAAAARLRTVIARGEQRRHRKRIAALTARSGPAVPALRRALETTEAAVATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D936</accession>
    <name>A0A1H6D936_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81363">
        <property type="protein sequence ID" value="SEG81363"/>
        <property type="gene ID" value="SAMN04489712_11437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045017">
        <property type="term" value="P:glycerolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="8">
        <location>
            <begin position="53"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="WES_acyltransf" evidence="6">
        <location>
            <begin position="246"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="7">
        <location>
            <begin position="501"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG81363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="660" mass="71218" checksum="6FF95CBE67173AB3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DC10</accession>
    <name>A0A1H6DC10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="1">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tadA</name>
        <name evidence="3" type="ORF">SAMN04489712_11595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82851">
        <property type="protein sequence ID" value="SEG82851"/>
        <property type="gene ID" value="SAMN04489712_11595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="162" mass="17234" checksum="304DD5C4D21428AA" modified="2017-01-18" version="1">MNDAREIDPVHAEFEQPMRLALAEARLAMDDGDVPVGAVVLDATGQVIAAGHNERELTADPTAHAEVVALRAAAARLGGWRLAGCTLVVTLEPCTMCAGAAVLARVERIVYGAVDLKAGAVGSLWDVVRDRRLNHRPEVIAEVLAEECGAVLTEFFARRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DH50</accession>
    <name>A0A1H6DH50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84482">
        <property type="protein sequence ID" value="SEG84482"/>
        <property type="gene ID" value="SAMN04489712_11711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295905" evidence="1">
        <location>
            <begin position="42"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="244" mass="24941" checksum="47F71C2C884773CA" modified="2017-01-18" version="1">MSDQRVAVVSGGSRGIGKAIAVALAARGFAVAVGFQGAASAAAQVVEEITASGGRAIPVQADVADEGAVAEMFDAAEKSFGGVDVVVNSAGRLALSPIADLDLDELDALHRTNIRGAFVMAREAARRVRDGGALVNLSTSVVGLQFPTYGAYAASKGAVEAMTLVLARELRGRDITVNAVAPGPTATELFLEGKDEAAIQRLAKQPPLERLGTPEDIAEVVSFLASPAGHWVNGQVVRANGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DI76</accession>
    <name>A0A1H6DI76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ORF">SAMN04489712_11790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84909">
        <property type="protein sequence ID" value="SEG84909"/>
        <property type="gene ID" value="SAMN04489712_11790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG84909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="213" mass="23628" checksum="40A18FE5587EB4AD" modified="2017-01-18" version="1">MLPRQLGDPHERPQTYAPRTYARVVEATQPVQEHVFQRLLAQRIVMIGSEIDDELANRVCAQLLLLAAQDAERDITVYINSPGGVVDAGMAIYDIMQYLPNDVATVALGMAASMGQTLLCAGAPGKRYALRHARVMMHQPHGGIGGTASDIRIQAEQSLYLKRILAERTAFHTGRPLEQIEADSDRDRWFTAEQAREYGFVDHVIDTTDRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJ11</accession>
    <name>A0A1H6DJ11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84675">
        <property type="protein sequence ID" value="SEG84675"/>
        <property type="gene ID" value="SAMN04489712_11747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295959" evidence="2">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="14445" checksum="950A929D44E5FED7" modified="2017-01-18" version="1">MRAHSTALPAAVLTVLAALTSGCGEPATDGPTASTAPTSPANPAGSAGPAGSVTAAGQVVPVTVTVTKGRATGTGGRVKVPRGARVRITVTSDAADEFHLHGYDRSLRLEPGRPGVVELTADVPGVFEVELHEAGTRLFELQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKD4</accession>
    <name>A0A1H6DKD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative drug exporter of the RND superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_118102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85897">
        <property type="protein sequence ID" value="SEG85897"/>
        <property type="gene ID" value="SAMN04489712_118102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="689"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="207"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="767"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG85897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="792" mass="82154" checksum="F74E27CDEC7B8545" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKU6</accession>
    <name>A0A1H6DKU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose 6-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85453">
        <property type="protein sequence ID" value="SEG85453"/>
        <property type="gene ID" value="SAMN04489712_1187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="494" mass="53445" checksum="609C894632E0EC22" modified="2017-01-18" version="1">MSDSEVGAADRQVLVASNRGPVSFSLSGDGALSMRRGGGGLVSGLAGVAAAGRPGGMGGPEVVWVCAALSDADRMAARQAPDGRLDKAGYDTGGASVRMLDIPAATFQRAYNSVANSTLWFVHHLLYDTPNTPHFDARSRRDWQSYEAYNAAFADALARDAAPGAKTAIQDYHLSLAPRMLRDRRPDLKIVHFSHTPWAPPEYYRLLPDDIGAQVLEGILGADHAGFLTARWADAFLDCCEAVLGARVDRAARTVVHDGHVTRVGVHGLGVDGAELTARAQEPDVVARARALREQVGDRQLIVRIDRTELSKNIVRGLAAYRELLVNHPEWHGRVVHLAFAYPSRHDLPEYREYTAAVQRMAAQITDEFGTPEWEPLILQVNDDYPRSLAAYGMADVLLVNPIRDGMNLVAKEGPVLSERGCALVLSREAGAAAELGEDALTVNPYDVSQTAETLHQALLMPAAERAERCARLTAAATALPPQRWFADQLAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL84</accession>
    <name>A0A1H6DL84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85603">
        <property type="protein sequence ID" value="SEG85603"/>
        <property type="gene ID" value="SAMN04489712_11843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="26778" checksum="7528F8694179E9E2" modified="2017-01-18" version="1">MLKVIGAGFPRTGTMSMKAALERLGFGPCYHMVEVLAHPDHVDRWLSVGTGASADWDRVLEGYASSQDWPSSYFWRELSEAYPEAKVVLTVRDPHHWYLSFRMLISRRPGGIPPEQAPEAVRPVLVAMQRMRPMLDRMGQDVFGAGWHMGQDMPDEDRAVKAYHRHVATVRESLPEDRLLVFDVRRGWDPLCGFLGVEPPTGEPFPHLNDSASLQRMFDRMMTEGRLSFPFEADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DM58</accession>
    <name>A0A1H6DM58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86400">
        <property type="protein sequence ID" value="SEG86400"/>
        <property type="gene ID" value="SAMN04489712_11973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="359" mass="37092" checksum="6B8D29464C7F2D8D" modified="2017-01-18" version="1">MTVIGVLGGSGTVGRVVVDRLTEYGLGRLRVGGRDLDRAAAVCRAFPQATAEPMRVDLHDPQNLREFCTGCDVVVNCAGPSYQVLDAVARVALAAGAHYVDAAGDLAAIDALESAPPPELDERAAVFSAGLMPGLSGLLPRLLATGPLARLDVYVGGAARIGELSAVDALLTRGPQFGTALAVWRDGRIVPGALAPLRAVTLPGFRGRVHAWPFLSVETARLAADLGVGELRNYTVYVTEAIPRALAAAWADGGPAERHVPAVVAAADADIAATGPYYTLLFQAVPAPGQPAGPDRPRRLLLQTPDSYALSGVVAAITVGELLEGRIKPGARAAAECLDAADVFARLTGDPLVTAAELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMI5</accession>
    <name>A0A1H6DMI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86448">
        <property type="protein sequence ID" value="SEG86448"/>
        <property type="gene ID" value="SAMN04489712_11986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="15676" checksum="4441361894044B70" modified="2017-01-18" version="1">MDEDSELEARLRRAVAFLDPVPPESLRVAREALVFRALDAELAELAFDSLDDAAPVRGPGRAQGPRFLTFRAGETTIEVEVTDPPRRIVGRLIPADTAEPVRIRRPGGSTTVTVDALGRFTAPLSGPGPFSLRYGRVVTDWVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DML5</accession>
    <name>A0A1H6DML5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_118114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85946">
        <property type="protein sequence ID" value="SEG85946"/>
        <property type="gene ID" value="SAMN04489712_118114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="17043" checksum="AA421C33CF80F00D" modified="2017-01-18" version="1">MGRRRRRSRESALVWWAGFGLLLAAAGWQRSWRLALLTLLLWCGYEFLLVPTICRVMTRQGFSCREPVRGRLFACTPAHQQVKTDALWRLVGLRNPRRKKAAPDPNRETGMMVYSPKVRGRLAQADRALILLASAGTLITVIGMVYGFGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNH6</accession>
    <name>A0A1H6DNH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86852">
        <property type="protein sequence ID" value="SEG86852"/>
        <property type="gene ID" value="SAMN04489712_12018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14304" checksum="A8F61EE4C016E124" modified="2017-01-18" version="1">MVGALSPLPVDVVARTPLPAINALLRDSVGWPAYVQQITDVYQALPAQERARTTIVVSNYGEAGALDRYGPDHDLPTAYSGHHELHRQGPPPTDADVVVGVVADVRSGVKRYGSEGWGGRGEQGVPAAATGPGWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNR9</accession>
    <name>A0A1H6DNR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="7" type="ORF">SAMN04489712_12047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86990">
        <property type="protein sequence ID" value="SEG86990"/>
        <property type="gene ID" value="SAMN04489712_12047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG86990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="317" mass="34233" checksum="66108166A486F2A4" modified="2017-01-18" version="1">MAPVVTMRQLLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLQQSLSYIDRAYEFIKETVAHGGTILFVGTKKQGQEAIAEQAQRVGMPYVNQRWLGGMLTNFSTVHKRLTRLKELEEINYDDVAGSGMTKKELLGLKREKDKLERTLGGIRDMARVPSAIWIVDTKKEHIAVNEARKLGIPVVAILDTNCDPDEVDYPIPGNDDAIRSVSLLTRVVADAVADGLMARAGAATGGEDKPAEAAAGAEPLAEWERELLEGKEQAEAAQPTAEAAPEAAPQAAEAAPEAAEAAPEAAEAAPQAGEAAPQAGEASDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPW2</accession>
    <name>A0A1H6DPW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent protease with chaperone function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86823">
        <property type="protein sequence ID" value="SEG86823"/>
        <property type="gene ID" value="SAMN04489712_12010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="73"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG86823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="38634" checksum="74B549529BE16746" modified="2017-01-18" version="1">MPDMTKNTPDRARTRFPGISSRAYEHPADRSALVALRSLTGFDTVLRRLSGMFSERALRLMFLGGSVRVGEDQFRNIHDMVRDAAYILDFDEVPELYVVQDPTPNAMAIGTDKPFIVLNTGLIELLDDEELRYVVGHEVGHILSGHAVYRTMLLILTSLGARLAWLPLGNLAIGAIVIGLQEWQRKAELSADRAGLLTSQDVHAVKRALMKMAGGPQLTEMNVEAFHRQAREYDAAGDVRDGLLKFLNLMQRSHPYAVVRFAEIDKWAGGAEYRRIMEGHYPRRQDDGSAKVTDEIRNAAKAYRDSWNETADPFVGKLRDIADGAAGLAGDLFARAGRRGGGQDRGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQH5</accession>
    <name>A0A1H6DQH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_120138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87470">
        <property type="protein sequence ID" value="SEG87470"/>
        <property type="gene ID" value="SAMN04489712_120138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="69" mass="7564" checksum="ABB3A081F9C73C26" modified="2017-01-18" version="1">MAFIPDPSRAAWRKSTRSSGTGACVEVAKLRQLIGVRDSKNPDGPKLSFTPRTWEAFNAGIKSGDYDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWF7</accession>
    <name>A0A1H6DWF7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="9" type="ORF">SAMN04489712_12425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89680">
        <property type="protein sequence ID" value="SEG89680"/>
        <property type="gene ID" value="SAMN04489712_12425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="570"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG89680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="616" mass="66160" checksum="751F3937196A7BDD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX22</accession>
    <name>A0A1H6DX22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89818">
        <property type="protein sequence ID" value="SEG89818"/>
        <property type="gene ID" value="SAMN04489712_12476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="44399" checksum="A6B0CCC3270CE48C" modified="2017-01-18" version="1">MSREAVDHALKTLREDRDRISANLLDLENHHGYRLLKGARLAGPTRRRWDDVTARLTLLWRLFDAYQRILDEAGQVRDRQTRPGEATLRELTALLSGPSVELPLDEVPLERRTLLGPTSERLTLAEAVGRMTAAYDEAIGLISAVDAAWETLLGPLDAAEEEWREAARLARSLAAGRDAELDRIGRELAAAGQLVRTDPLALVRDGRADTARLDAVRADLAKVRDVLVEAVRVREEYDRRVGGIESALTRLGEVLAQARDAYRTVQVKIASPGVDEPADPTPVLRERLAALAGLRDAGRWPELAGRVAALEGAVAAALEQAERSRRLIGGLLERRDELRGRLDAYRVKAARLGFAEHDELTRLQEQARELLWTAPCDLQRSTVVLAQYQRVLRSLETGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXM5</accession>
    <name>A0A1H6DXM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89325">
        <property type="protein sequence ID" value="SEG89325"/>
        <property type="gene ID" value="SAMN04489712_12368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="197" mass="21317" checksum="C8D242A3BDCD14F9" modified="2017-01-18" version="1">MSKSARNRNNRQNVLTKTSPPWGAIAFFTTIGVIVLAAVGFAAWQAFKPAEAIAGLVEKDGLKQDHVQTPVTYDTTPPMGGPHHPVWQNCDGRVYDQPLKNEHAVHSLEHGAVWFTYRPGLASGELDKLKSKVEGTDYTMLSPVQNQDAPIVLSAWGKQVKVDKADDGRINAFLKAYLKGPQTPEPGAACSGGKDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY39</accession>
    <name>A0A1H6DY39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90228">
        <property type="protein sequence ID" value="SEG90228"/>
        <property type="gene ID" value="SAMN04489712_12575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="9979" checksum="0EEF93619C01FF5F" modified="2017-01-18" version="1">MLGTDASTFAAVFVALYAAHQVGDHWAQRSSEALGKGGPGWRGRWLCARHVVALAVGKAAALGLTAVVLSLPLNGWAVLAALAVGASPRDVDTLETGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZN1</accession>
    <name>A0A1H6DZN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90394">
        <property type="protein sequence ID" value="SEG90394"/>
        <property type="gene ID" value="SAMN04489712_12624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="27611" checksum="547679F9711C5CBE" modified="2017-01-18" version="1">MDEPRRVALISGASRGIGAATAREMGRRGYHVVVNYRQNAAAAQGVVDEIKAAGGSAEARRADVCDGDQVGDMVERVLADHGHIDVLICNANTVNPPFEPLLSVSWDAFIGKVSGELAGSFFLTRHVLPVMQRRGEGRIVYISSTAADLVGSVAAHSTAKAALNTFSRHVAAAAAQHGVVVNTVAFGTVRTDATAGVLNDDLRKFTEERSVLGRLMDPEDAARSVAAVADDGFGAAVGQVIRVDGGFDVLDQQLHTVVKHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1S9</accession>
    <name>A0A1H6E1S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Simple sugar transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91532">
        <property type="protein sequence ID" value="SEG91532"/>
        <property type="gene ID" value="SAMN04489712_12951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296438" evidence="2">
        <location>
            <begin position="30"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="54"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG91532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="332" mass="34319" checksum="2CD46F5DF2ED42C9" modified="2017-01-18" version="1">MYSGFSRKAVLAGAAAGLLALAGCSNTGASEGDTGGAGKLTACVTTLFPTGTFAEFVTALKSQGEKRNMSFDVQHVNNDSSKENQVLSACATRQVDVVIASVVSPTGSVASLQRLESADIPVICYNTCLNPPQDQQLAAAFVTNDQVELGERAAEAATGYIKEKLGGTAKVAYLTCETYDVCKQRRQGLDKGLAGVNATVVAAQEGFVVDKATPVATSILTAHPDVDVFIAENEDGVIAAANAIKARGLTGRTVVFGIGMNPTVAGLLLAPDGVVQGTIGQDAASWATEVVEIADAIRNGRDTGPFHHYTPGPGFSHDDPGPVRQYLQTQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1T5</accession>
    <name>A0A1H6E1T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate decarboxylase (ADC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90885">
        <property type="protein sequence ID" value="SEG90885"/>
        <property type="gene ID" value="SAMN04489712_12767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG90885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="24271" checksum="C8DB9CAF5C90F4AC" modified="2017-01-18" version="1">MPVQIREASVASAMFPVPARTAQEIIGYSGLEVLRPLPGRAVCALAFVRYDDGDLGPYHEFAVTFLVRDPAPPPGRLKNVGVFVHWLPVDQSFTLEAGRSIWGFPKLMTDIPLDLDGRVKHCAVRVDGRPVVEMAVLPGLPVPGGGAPEIAAFSCLDGVTRRTPWTTRPTGVRLRPGGAAVRVGGPPDAHPIVEELRRLGLPRARALSSATVAHLSMTFHDAQRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E237</accession>
    <name>A0A1H6E237_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91738">
        <property type="protein sequence ID" value="SEG91738"/>
        <property type="gene ID" value="SAMN04489712_13036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="37847" checksum="CB79606E9585B36E" modified="2017-01-18" version="1">MTGSTILDPLTMKRLAFIRLLYQQGVDQSRLPEPLNFTSVLSFHDAVEHFLVLTGEHLGATLPNHIQFMRYWDELHPNKLANGIVLSGKVAMDRLNRARNNFKHVGALPGTPTVEQARGDVTAFFEDNTPRVFGAAFNEIDMADLVTHEDTRSALKRAAAAWDAGEHVKAMALLVNAFDDLFDEYVSAKGARQAFAFGPQIGVPLLSARIATLLEARPSRAARKEIDLIAELLDQVAMFADPAQQALRVMSLGIAYDEYVRFRSLCPWIMRMDPDLFVQRPKDYTPTVNDFRYCQQFMITVALRITEMQTHLPEVRQGEKETLEFTISMDGSEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2W9</accession>
    <name>A0A1H6E2W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91972">
        <property type="protein sequence ID" value="SEG91972"/>
        <property type="gene ID" value="SAMN04489712_13150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="187" mass="19859" checksum="BFBF391587A23EB6" modified="2017-01-18" version="1">MQGLTSDTAYVSSYLTTIEGPKVLVGHSYGGAVITNAATTVPDITSLVYIAAFIPAKGETVGELAAKSDPALPLVSTPVPGGTEVIFDPARFRTAFAGDLDKATAAELAITQRPATTRAVTDPSVEEGFRTIPFWALVTRQDRAIYPDVQRLMTTRAHARTTEVDASHSVMLSRPGAVTEIIERAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E369</accession>
    <name>A0A1H6E369_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell volume regulation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92138">
        <property type="protein sequence ID" value="SEG92138"/>
        <property type="gene ID" value="SAMN04489712_13236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="5">
        <location>
            <begin position="384"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="481" mass="50381" checksum="105A8BB20B57FAEB" modified="2017-01-18" version="1">MLSAILAVRLSHRLGLPSLLAYLGLGLLIGESGFGINFDNAELAQTLGWAALVVILVEGGLTTNWRNVRSAVPVALALATLGIAVSIVVVAVAAHWLLALNWRLAFLLGAVLAPTDAAAVFSVLRRLPIPRRLAGILEAESGFNDAPVVIIVVLLSSVEAHGPGPWLLVPLVVYELAAGAALGLLLAWLGIFALRRAALPASGLYPIAVLSLAVGSYGVATLVHASGFMACYLCALLLGNARLPHRPATRGFAEGLAWLAQIGLFVMLGMLASPSELPAQVIPALVAGSILVLVARPLSVWASTLGFGLGLREKVFLSWAGLRGAVPVVFATVPMSADVPGSDRLFSLVFVIVVVFTLLQGPTLPPVAGVLRLPVEGEAKDLDVEAAPLEELKADLLEVRIPADSALGGVEIFELRLPAGASITLIVREGRSFVPEPTTALRGGDILLVVTTADVREATERRLRAVSRRGRLAGWFGERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4Y7</accession>
    <name>A0A1H6E4Y7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">csrA</name>
        <name evidence="3" type="ORF">SAMN04489712_1326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92056">
        <property type="protein sequence ID" value="SEG92056"/>
        <property type="gene ID" value="SAMN04489712_1326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="60" mass="6714" checksum="A3FB6A1707BFEBBC" modified="2017-01-18" version="1">MLVLSRKSGEKLMLGDDIVVQVLQIAGNSVRLGIEAPRSLRVWREEVWVKLNGDGRPVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E508</accession>
    <name>A0A1H6E508_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_13146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91965">
        <property type="protein sequence ID" value="SEG91965"/>
        <property type="gene ID" value="SAMN04489712_13146"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG91965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="37835" checksum="A95DFDD2023D74E9" modified="2017-01-18" version="1">MLLDPGMNLTLRPMRYPAFYDRYRAAIRNTWTVEEVDLHSDLADLARLTPAELHLVNRLVAFFATGDTIVANNLVLNLYKHLNAPEARLYLSRQVFEEAVHVQFYLTLLDTYLPDHTERAKAFAAVDNIPAIRDKAEFCFRWIDSLGDLDELRTRHDRRAFLLNLICFAACIEGLFFYGAFAYVYWLRSRGLLNGLASGTNWVFRDESMHMEFAFSVVDTVRAEEPDLFDDALTGQVTRMMEEAVAAELAFARDLCGDGLPGLSAEDMRAYLEYVADQRLARLDMPARYGTANPLAFMELQDVQELSNFFERRVSAYQIGVEGTVTLDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5U6</accession>
    <name>A0A1H6E5U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93062">
        <property type="protein sequence ID" value="SEG93062"/>
        <property type="gene ID" value="SAMN04489712_1371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="21774" checksum="74E4D5F32F329A40" modified="2017-01-18" version="1">MVFVDPDSLESGGAPTLGEPLAVEFGNTRYAVRGNPQEGLAKPEHLAAWLRDYAGAFVPGAADAAVTALAPDDLGRFLRLRDVVRDCTRAIVNGHHPSAALIDELNAASALAPAWPRLEPSGDDLTVTAMTSANPVDAVLGTIARSAIEIFGGPNRTALRACGGPGCILFFVKNHPRREWCSPGCGNRARVARHYDRHRTTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6G8</accession>
    <name>A0A1H6E6G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93398">
        <property type="protein sequence ID" value="SEG93398"/>
        <property type="gene ID" value="SAMN04489712_13843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="20972" checksum="A7271E3A330963DE" modified="2017-01-18" version="1">MANWRDKITVAPPWAYFLLTCAFCGPSFGVLMWLLMPQADAWSALAGGVAFGVGFPAFITSSVVRERRRLRETAGDLSRQDLLALARAVRVGEPPADPALDRPLLAMLERRRTQLESAARSNPWIFGALAAVGLLRAFTEGEPRVYAGTAVLLVLLIVSLKLLSMRRTRLERLEQQISAREERPATQPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E947</accession>
    <name>A0A1H6E947_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94280">
        <property type="protein sequence ID" value="SEG94280"/>
        <property type="gene ID" value="SAMN04489712_14510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16865" checksum="7B99D28F2B7A3D4F" modified="2017-01-18" version="1">MTRPQTRARLEDALSRLLAGQPIRTDGQLTVTNLCREAGVGRDSFYRSPDIVARFEAAKANAQAHKPELLQLREEIAELKRERRKLKSDHARTVRELEKTIRVYANQIQVLALRAAELEGKNTRLRRQLAEDAGVTAIGLASPELSEAPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5RYU4</accession>
    <name>A0A1H5RYU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LexA-binding, inner membrane-associated putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43523">
        <property type="protein sequence ID" value="SEF43523"/>
        <property type="gene ID" value="SAMN04489712_10111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF43523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="25298" checksum="60FD92AA51EDDD2D" modified="2017-01-18" version="1">MMGRTHALSGAVAWLGAVPFLSQERLLGDFAVTLSPAQVLAGTVVCAGAALLPDVDHHNGRIANTMGPVSKGFCKWVGKISGGHRQATHSILFAVGVGLAMDLLATHFVYGWWAALFVTVGFGLRGIGLDFEKHEVWSSVADCAVAALAVWLMRDLDMSFVGYAVTLGCLAHVAGDCLTPRGCPVFWPAKWRVDIPLVPRTDGKVERWVIAPALTLGAVILAVRSVLGDEAVRWLNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5RZ62</accession>
    <name>A0A1H5RZ62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kynurenine formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43646">
        <property type="protein sequence ID" value="SEF43646"/>
        <property type="gene ID" value="SAMN04489712_10115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF43646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23243" checksum="498FC1405EECFEBC" modified="2017-01-18" version="1">MTFIELSHRVTAGMVTYPGLPGPRITDHVSRAQTAERFGPDIAFQIGEITLVSNTGTYVDTPFHWYADGTDLSEFPLERLADLPGVVVRPRPGHRALDAADLAGVDVAGRAVLVATGWSRHFGTERYGAPDHPHLTRAAVDALIGAGAALVGIDSVNIDDMADKSRPAHTGLLAAGVPIVEHLRGLEELPPDGFRFTAVPPPIAGMGTFPVRAYAVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5RZC1</accession>
    <name>A0A1H5RZC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43669">
        <property type="protein sequence ID" value="SEF43669"/>
        <property type="gene ID" value="SAMN04489712_10116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF43669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="198" mass="21512" checksum="9539A4DD098434D1" modified="2017-01-18" version="1">MDSVDADQVAMLREVLSATGWLERTGEFARALRGSAREPGGLLLVGTPTGEPWHMAAHLDDESRLNHIPELSPTLVRWSPPPQAPPHLRVGLERLEAVRRGEALFVVAEDKAPVPLLERVDDARRTGATILTLDGGDRELSGLAHEALVVPPRERLLSFDGAQHLVSAAAGAPPQRRHGLRDRLARLLDRVSGPVTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SH46</accession>
    <name>A0A1H5SH46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49939">
        <property type="protein sequence ID" value="SEF49939"/>
        <property type="gene ID" value="SAMN04489712_101208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009499">
        <property type="entry name" value="DUF1116"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024033">
        <property type="entry name" value="Uncharacterised_dom_sf_YlbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06545">
        <property type="entry name" value="DUF1116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF49939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="469" mass="48684" checksum="5425A1852EB617F6" modified="2017-01-18" version="1">MNGRLGGLLGREPRVVAVGAPALAEALEQQAVAVQPVDWRPPPAEAVDALNAVLGDPRHATANATAVGRMLAARPRLVDVRPAGEVLGLEPGLFLHAGPPLEWDRASGPMRGALIGAMLLEGLAASPEEAERSLAAGTARLDSCHHHAAVGPMAGVVSPSMWMFVIEDTENGAARRSYCSLNEGLGKVLRYGAYGPEVIERLRWMGAVLGPVLRDAVRRHGPVDLTAITAQALQMGDELHNRNRAATSLLVRELAGDIVLAGAPPDRLAEVLRFVHGNDHFYLNLAMAAAKVSADAARGVPGSSLVVAMARNGTDFGIQVSGTGDRWFTGPAGTPDGLYLGSYGPADANPDIGDSTIMETAGLGGFAMAAAPAIVRFVGGEVPDALAATRRMREITLAEHPVFQVPILSFRGTPTGVDVTRVVRTGILPVINTGMAGRVAGTGQVGAGLVEPPAQVFTAALHALATQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SI21</accession>
    <name>A0A1H5SI21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-methylhydantoinase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50333">
        <property type="protein sequence ID" value="SEF50333"/>
        <property type="gene ID" value="SAMN04489712_101223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="2">
        <location>
            <begin position="210"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF50333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="715" mass="76234" checksum="888E77D17918F296" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJV6</accession>
    <name>A0A1H5SJV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-monoxide dehydrogenase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50101">
        <property type="protein sequence ID" value="SEF50101"/>
        <property type="gene ID" value="SAMN04489712_101214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF50101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="17878" checksum="99F402041EF6EC58" modified="2017-01-18" version="1">MNGERTHRIAMTVNGTYREAAAPARRLLSDFLRHDLGLTGTHVGCEHGVCGCCTVLLDGEPVRSCLMLAVTADGHEITTVEGLATGGELSPVQRAFQECHGLQCGFCTPGFLCTVTALLRDNPRPTEEEVLEGISGNLCRCTGYQNIVKSVHRAADLIAEAGREPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SNE3</accession>
    <name>A0A1H5SNE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative spermidine/putrescine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51970">
        <property type="protein sequence ID" value="SEF51970"/>
        <property type="gene ID" value="SAMN04489712_101286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF51970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="28151" checksum="6D92DF67413FAA81" modified="2017-01-18" version="1">MNNGSRAARAALWAFCALVGLWLVAPVLVVVPLSFTDKPSLVFPPTGWSTRWYANFFGDPRWTDAFVNSIKVGLLVTLTATVLGTLAALGLTRARLRGLPIAQGTLLSPMIVPGVVFAIGTYALFLKLQLVGTLFGFVVAHTVLALPFVMIPVTASLAGFDRRLEQAAAGLGAGRWTAFRTVTLPLVAPGVVSGALFAFVTSFDEVVVSLFIQSPYLQTLPVQMYGSVTRDTDPTIAAAATMIITLTTAIVLAATLLTARRSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SQ60</accession>
    <name>A0A1H5SQ60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52736">
        <property type="protein sequence ID" value="SEF52736"/>
        <property type="gene ID" value="SAMN04489712_101318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF52736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="103" mass="10220" checksum="0068570A3CB2521B" modified="2017-01-18" version="1">MLPLVLLPLGAVAACGGEGTTTDCSLNACTVTFDRGVDANASILGVKAELVGVQGDNVTLRIGGQQVTVPVDGQQQVEGLNVAVQSVTQDNVVVKISGGGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SUZ8</accession>
    <name>A0A1H5SUZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54413">
        <property type="protein sequence ID" value="SEF54413"/>
        <property type="gene ID" value="SAMN04489712_101376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF54413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="127" mass="13791" checksum="1634079851C2C35A" modified="2017-01-18" version="1">MRRDGRTDPFFDGAAADRLVIRRCERCDRWYAPDHGGCSGCGDEELSWAEATGEATLVTWAVKHGRPAGDGTAPPPAHLALVELAEGPWLHARLDGVNASALREGLPLRASFVHPDEGESYLLFRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SXJ0</accession>
    <name>A0A1H5SXJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MerR family transcriptional regulator, redox-sensitive transcriptional activator SoxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55293">
        <property type="protein sequence ID" value="SEF55293"/>
        <property type="gene ID" value="SAMN04489712_101403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01110">
        <property type="entry name" value="HTH_SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010211">
        <property type="entry name" value="Redox-sen_tscrpt-act_SoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30204:SF0">
        <property type="entry name" value="PTHR30204:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01950">
        <property type="entry name" value="SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF55293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="168" mass="18861" checksum="B41CFE247700B772" modified="2017-01-18" version="1">MTQSARNRYELTVGQLAERSGVAVSALHFYEAKGLIHSRRTAGNQRRFTRDTLRRVAFIRVSQRVGIPLAEIREALSRLPEERTPTVDDWAALSESWREKLDERITQLQRLRDDLTDCIGCGCLSLNRCALANPYDELGKQGPGPRRLLVSAAKDPRPPAAECISCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T7C6</accession>
    <name>A0A1H5T7C6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske-type oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58696">
        <property type="protein sequence ID" value="SEF58696"/>
        <property type="gene ID" value="SAMN04489712_101511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF58696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="36945" checksum="C1D999DA65B27AF6" modified="2017-01-18" version="1">MARFPFPIPNGWFAVARSEELAAGQVRPAHYFGRDLALFRTASGEARVVDAYCPHLGASLAHGGQVAGELLECPFHAWRFDGVSGRCVEVPYTDAEPSPKAKVRSYPVIERFGLVFAWHHLGGAEPYVPMPEMAEFDDETWVAPVFHEFRIATCVQEMAENNADYVHFKYVHGMETVPGGEVAYDGFVKTVTERQEFKNKEGKVYSLDFVRKSYGLGLGALRLKGVMSFVSSVTPVDEENVHIRWMFTFPKSMERFSPRMINEFVKQIGEDVPIWEHKIYVDRPLLIKGDGPIIEFRHWARQFYGEGVPDSPWIPNRVKRLEGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T9P8</accession>
    <name>A0A1H5T9P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59510">
        <property type="protein sequence ID" value="SEF59510"/>
        <property type="gene ID" value="SAMN04489712_101537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF59510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="30733" checksum="C4C483B6076E415E" modified="2017-01-18" version="1">MGATLSLTIPESTTTRFLIATDDRSAPGVQRLRDALPAGGLARTARDLLASPLLLVTGCRAADSPWACRLPGLGGGAAELAALRSARHHLVVTSIATPAAQPRHAQAARLVARTLAAITGGRVADLAANQLLTDPTGTESERFALHDDWLGVFVSPDPGPNLRADTAGLHRFGLPELLVRGVPYGRLLTAVNVLRGLAFRLLADHRAWLSAAPGAGDRQLPADPDLDLGDILRYWGTDPPDLGGPLPLHLVPSPADCPECGTGLRITPPGGQADLDWWDRTVAPAMPVHPEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5THP3</accession>
    <name>A0A1H5THP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61537">
        <property type="protein sequence ID" value="SEF61537"/>
        <property type="gene ID" value="SAMN04489712_101598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF61537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="298" mass="31092" checksum="5D121E9DB45E3FCC" modified="2017-01-18" version="1">MIEVSELTKRYGDVAAVRNVSFRCEPGTVTGFLGPNGAGKSTTMRMICGLTPPTSGSAAVLGVPYRRIANPGRHVGVLLDAAAQHSGRTGRETLALSAQVLGVDRERAGRMLREVGLPPAAARRRVGGYSLGMRQRLGIALALLGDPRVLILDEPANGLDPEGIHWMRTLLRGFADRGGTVLLSSHLLREVEAVADRFVVISGGRIVAQGDKGELLTTSGGTFVRGLDPGALETALAEAGLAARRCGPDAFTVEADAEAVGRAAAKAGAVLLELRSAGEGGLEELFLSLTAEPKENAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U4F9</accession>
    <name>A0A1H5U4F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69288">
        <property type="protein sequence ID" value="SEF69288"/>
        <property type="gene ID" value="SAMN04489712_101847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF69288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="26842" checksum="A476B31FA257396C" modified="2017-01-18" version="1">MPLVLSAAADMEPVHGFNAYSLAILLHIVLFVYWLGSDIGVFYSSRFILRAELPTPARSVAAKIMHAVDMAPRICLVLFLPSGVTLMALSPFGEDVFPGWLLALSWVGALCWLALVVYDYTRGATPLGALVQKLDLIVRYGLSAGLLVVSGYVFFAAEPFGVTTNPKWLAAKVAAYALCILSGVMIRRRLSPFGPAFGRLVSEGSSPEVEQQIRHSVRSCLPYVYAIWFLVLVAAFLGVVKPGTTAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UU44</accession>
    <name>A0A1H5UU44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA binding domain-containing protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78480">
        <property type="protein sequence ID" value="SEF78480"/>
        <property type="gene ID" value="SAMN04489712_10223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF78480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="12398" checksum="169D38EDA81B230A" modified="2017-01-18" version="1">MTTSGKDATPTPPERSKVGRDPDILTTEELATKLGLSPQTVRRMAAAGQIPALKAGKNFRYSWSAVLDVLRQPHPQPGATANDQNPDQDPVRTTTPPTGAGYRAQRQARAGAQHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UVZ6</accession>
    <name>A0A1H5UVZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF695 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79239">
        <property type="protein sequence ID" value="SEF79239"/>
        <property type="gene ID" value="SAMN04489712_10257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016097">
        <property type="entry name" value="DUF695"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05117">
        <property type="entry name" value="DUF695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF695" evidence="2">
        <location>
            <begin position="228"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF79239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="345" mass="37900" checksum="A864671416D1EA02" modified="2017-01-18" version="1">MGIFRRPRDASRSTPLPAITEFWDWWAQARPRIEAALGEGLSADLVEELSLRIHRIHPELQWELGRPDDGAPALTVSGGGSAELRGLAERWLRAAPADTAGWSLHAARQPDPEMLGQRLVLGDHEFDLEYVRMGMRVDNARARIHVAAYHPDFLFVPEEARVQVALHVLDWALGEDDVARWVGEVTAVAEPPMDSLPPGMLPAVVGQVSEPFREPTWLSGEGRTPRGHPARLGARFPLHRQDHPLCDLHVALSVPYAHSNPDRLPVEPSASALRDLEKKLDDLGPGAVLAVRETGDGLRVFHLYADPDSGVLARLDQLAAGWPEGKAKVASTPDPGWRALAPYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UX80</accession>
    <name>A0A1H5UX80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, contains Zn finger domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79646">
        <property type="protein sequence ID" value="SEF79646"/>
        <property type="gene ID" value="SAMN04489712_10273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF79646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="29798" checksum="060A1497E26ADF8E" modified="2017-01-18" version="1">MDFSERREPLPVTDGIRSLSERGSIGREWWSRRFVDVLESFADRNRLHRGRAYARKGQVIDLKVRPYEVRARVQGSRPEPYEVAIGIDAIGEETWRVVEAELASRAVFRARLLAGELPPEIEWVFAELGVPLFPASAHDLHLMCDCPDYGDPCKHAAAVLYLLAEAFDRDPFLLLAWKGRSRDLLLQGLRRLPAEGAPDPFDVGDEPLTAAGFWTAGPGLAALRDRPPAAPAPPDLLLRLLDPPAVKVRRRPLIDMLGPAYEAMPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UZF8</accession>
    <name>A0A1H5UZF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_102104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80552">
        <property type="protein sequence ID" value="SEF80552"/>
        <property type="gene ID" value="SAMN04489712_102104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="97"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="541"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="795"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="575"/>
            <end position="582"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF80552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="819" mass="84143" checksum="EC2827757915BAB6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V5K3</accession>
    <name>A0A1H5V5K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholest-4-en-3-one 26-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81727">
        <property type="protein sequence ID" value="SEF81727"/>
        <property type="gene ID" value="SAMN04489712_102144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF81727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="415" mass="47043" checksum="E06797FD358824E1" modified="2017-01-18" version="1">MRPQIDVRPDIDIIDPGVYERGGIPHEQFRWIRDNDPVFWHHDLNEGVPGFWAVTRHADVVHVSRNPELFSSHVRSSLYEEFSEDDLALFGLMMLFQDPPDHTRNRLKVNRGFTPRMIKQLEGHIRDICNELIDRVSPLGQADFAEDIAAPLPAYIICELLGAPQEDREQICDWSNKIIGFSDPEMAGAKEEAAALSAELMAYASELAAQRRAEPRDDIATKLLQPDEHGNVLSDEEFQLFVLMLVIAGHETTRTGSVNGIQAFFDHPEQWERLKADRSLLRTAPDEIVRWTSPLNLFRRTATRDTELGGKQIKKGDKVVMFYGSANRDERVIEDPFTFDIGRDPNPHVGFGGGGPHFCLGTHLARLELAVLFETILDRMPDIRPAGPPRRLRSNFVNGIKELRVEFTPSPSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V745</accession>
    <name>A0A1H5V745_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein, AIM24 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82561">
        <property type="protein sequence ID" value="SEF82561"/>
        <property type="gene ID" value="SAMN04489712_102174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF82561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="23501" checksum="9DEDD8B77A9220C5" modified="2017-01-18" version="1">MRSPFFGNMEQAQLPGHFALQNSKMLRVHLNGDVLARQGSMVAFQGQMDFDYEGSGGVGRFLKKALTGEGVPTMRVKGQGLLFLAHDADDIHLFYLENETLTVNGANILAWDAHLQSDIQRVQGAGIAAGGLFNTTLSGTGWVAITAHGTPVMLDTGRAPTFVDGQSAICWSAGLHVGVNRTIKAGALIGRGSGEAMQLAFQGQGFVLVQASEGPTVPTHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VC09</accession>
    <name>A0A1H5VC09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84892">
        <property type="protein sequence ID" value="SEF84892"/>
        <property type="gene ID" value="SAMN04489712_102259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009287152" evidence="1">
        <location>
            <begin position="31"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF84892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="27436" checksum="57D0F5CBF9A2AFFD" modified="2017-01-18" version="1">MKPRTLVTRFAAATTVVMAFGLASAPAAVAQDGAPGMRVKEHGTRVKVTGPGFVVKLSKHGLDVRINEDRFGDPDSGYPIQRQTLDLTGRPARPFECENGTYTVKTGTFERTFRFSSTDPRPLPYPPEFAAGFPGILTPFVGVIKGTVTNAEGETLNFLISDLAQEVLTEDGFSATAPIHGLFIDGRGRIRDHISLVGRFNSGPNGENATYRIEDRGTCRQTADLPYGPDSKGVLVTGPIFVFPFKAPVTTPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VHR9</accession>
    <name>A0A1H5VHR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86341">
        <property type="protein sequence ID" value="SEF86341"/>
        <property type="gene ID" value="SAMN04489712_102313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF86341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="22027" checksum="0FDADDEBB52236CA" modified="2017-01-18" version="1">MRLTREPVAAPVPVAEPPGPVRSYGLVALVAVRGELLRYGVAAMLRELAPLVGEVVEDGRLDGRHVDVVVLSPGADTAALADRAARRRIRVLGLVDETAGDVLDAYVDGVVPYRDLTLETLRDALTGTPHTRPATRADRPRRALTPRERQVLGLVAQGLSNKQIARRLAVSEHGVKKHVASLLTKLDCPNRTIAAVRALNDGLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VHY3</accession>
    <name>A0A1H5VHY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate dehydrogenase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 4 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86834">
        <property type="protein sequence ID" value="SEF86834"/>
        <property type="gene ID" value="SAMN04489712_102329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015944">
        <property type="term" value="P:formate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014603">
        <property type="entry name" value="Formate_DH_Fe-S_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036298">
        <property type="entry name" value="FDH_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036298-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF86834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="32672" checksum="B42E2363485534E8" modified="2017-01-18" version="1">MTDPAAVSGYEDPPPRMGFFTDTSVCIGCKACEVACKEWNAVPEDGLLLTGMSYDNTGSLNASTWRHVAFIEQRKPLALQDPGVMHPDVDVLEMAPLGSSTPPEQALMTPTAPGQEGDLRWLMASDVCKHCTHAACLDVCPTGSLFRTEFGTVVVQEDICNGCGYCIPACPYGVIDQRKGDGRAWKCTLCYDRIGDGLEPACAKACPTDSIQYGPLDELRERAAGRVERLHEAGVTDARLYGHDPADGVGGAGAFFLLLDDPEVYGLPPDPIVTTRDLPSMWRHAAAAAAGLLGAAVLACLTGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W9E9</accession>
    <name>A0A1H5W9E9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="5" type="ORF">SAMN04489712_102638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96112">
        <property type="protein sequence ID" value="SEF96112"/>
        <property type="gene ID" value="SAMN04489712_102638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="4">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF96112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="24834" checksum="3DFFEA4D8598906D" modified="2017-01-18" version="1">MDIIVKGRHTDVNERFRQHVDSKLARIERLDQKVIRVDVEVSEERNPRQADRRERVELTIRSRGPAVRAEAAAEDRYGALDLAIDKLESRLRRSADRRKIHYGSGNRAPAKLARMEPLPELAPMPSSAPVGTAEPETPEPASSAEAEGNLIPLPADGDCPVVVREKFHQSAPMTIDQALYEMELVGHDFFLFRDKESGQPSVVYRRRGWDYGVIRLMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W9X9</accession>
    <name>A0A1H5W9X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96190">
        <property type="protein sequence ID" value="SEF96190"/>
        <property type="gene ID" value="SAMN04489712_102640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF96190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="10729" checksum="382284950FBF1499" modified="2017-01-18" version="1">MRGLAEVAVRRLRAEGFPVACATVLRQGRPVADQAGLSAAARAANLAGALRVTAARRVHGRRVVVVDDVITSGATLTEATRAIEAAGAQVMAVATVAATPRRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WYK8</accession>
    <name>A0A1H5WYK8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04614">
        <property type="protein sequence ID" value="SEG04614"/>
        <property type="gene ID" value="SAMN04489712_10318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG04614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="242" mass="24997" checksum="A048F84F6404BDC0" modified="2017-01-18" version="1">MVLRIRVRLPDRPGSLGKVARILGAAGADVVQMAVLERDSGRALDDFTVAWPTGAGIERLCEGLASVPGVEVVGIWPTLEPPGTNQDATLIGQLAAAREDAGLAILTDAVPAMLSADWAGLVRIEQGIEQGIGQEEAAGAVLVHTSLGVFGGIEVPPLEPLRPRAFTAEDGTRYALVPIGGGELALLVARTGAPPFHRSEVLRLAELVNAAEAVLGQRVRALPEPALRPDPAVITPSGGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X5C0</accession>
    <name>A0A1H5X5C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent oxidoreductase, nitroreductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06964">
        <property type="protein sequence ID" value="SEG06964"/>
        <property type="gene ID" value="SAMN04489712_10395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG06964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="18353" checksum="E0B214C449407621" modified="2017-01-18" version="1">MAALIQKTFGPIFHRISGSPRFARVGPRIVPPLDRALHRATGGRLMLGQLLVPSLVLTTTGSVSGLPRQVPLACMPEPDGGWVVVGSNFGRERHPAWTANLLKEPKATVAFRGRTVSVTARLLDDAERAEVWPRLLRVWPVYGRYAERVDRELRIFRLVPDPPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XLW6</accession>
    <name>A0A1H5XLW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12367">
        <property type="protein sequence ID" value="SEG12367"/>
        <property type="gene ID" value="SAMN04489712_103300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014529">
        <property type="entry name" value="UCP026631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026631">
        <property type="entry name" value="UCP026631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="290"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="425"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG12367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="516" mass="54533" checksum="4DCD0D1B1351C73F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XT31</accession>
    <name>A0A1H5XT31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14813">
        <property type="protein sequence ID" value="SEG14813"/>
        <property type="gene ID" value="SAMN04489712_103394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021491">
        <property type="entry name" value="DUF3145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11343">
        <property type="entry name" value="DUF3145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG14813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="17455" checksum="18241A8884F34A29" modified="2017-01-18" version="1">MTARGVFYVHSAPPALCPHVEWAVAGVLGVPASLTWADQPAAPGSMRAELHWEGKPGTAAGITSSLRNWKLLRFEATEDATPGCDGVRYSVTPSLGVFSGVIGANGDVMVPEDRLRAAMANVAVGKSTLEHEMDRLLGTPWDNELEPFRRAGDGAPVRWLHAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZA3</accession>
    <name>A0A1H5XZA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biotin-dependent carboxylase uncharacterized domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16606">
        <property type="protein sequence ID" value="SEG16606"/>
        <property type="gene ID" value="SAMN04489712_103465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG16606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="29327" checksum="1A00961CD6E7F470" modified="2017-01-18" version="1">MIEVVRSGPLTTVQDLGRPGHAHLGVPCSGAADRRSLCLANRLVGNPEDAACLELTFGGLALRFHAPAWIAVTGAPAPLRVDGRPAGMNAPCHVPAGAPVEIGAPAAGVRTYLAVRGGLAVQPVLGSRATDLLSGLGPAPLEPGDRLPVGEWRDSPPIMVDQAPVPPLAAEPLLRVRPGPRDDWFAADALDTLTGGPYEVTADSNRVGVRLTGRPLRRARDGELPSEGMVTGAIQVPPNGLPIIFLADHPTTGGYPVIGVLAEADIPVAAQLRPGQRVRFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YI50</accession>
    <name>A0A1H5YI50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23793">
        <property type="protein sequence ID" value="SEG23793"/>
        <property type="gene ID" value="SAMN04489712_10429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="110" mass="11792" checksum="8891250EC9C0CCF6" modified="2017-01-18" version="1">MSHADLPLPDYDHLPVATLQHRIRTLGRDDLRRLLDYEKEHAHRMSVLQVMKARLGQLDAGQEPSGGSARGSVPEHPPAAAGGSKVSPSTSGPPMNPPSHGDPTNPAQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YKI9</accession>
    <name>A0A1H5YKI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type I restriction enzyme, R subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23896">
        <property type="protein sequence ID" value="SEG23896"/>
        <property type="gene ID" value="SAMN04489712_10434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006304">
        <property type="term" value="P:DNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025285">
        <property type="entry name" value="DUF4145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013670">
        <property type="entry name" value="EcoEI_R_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13643">
        <property type="entry name" value="DUF4145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08463">
        <property type="entry name" value="EcoEI_R_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="435"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG23896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1168" mass="130952" checksum="540750E056C3D828" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YTJ7</accession>
    <name>A0A1H5YTJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27533">
        <property type="protein sequence ID" value="SEG27533"/>
        <property type="gene ID" value="SAMN04489712_104183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="29751" checksum="AC4799BA877F8EEE" modified="2017-01-18" version="1">MAYSGHPSRYRGEEGHHARLHTKWPAGTAGTAELSIPFDSWKPRARRRRWGACPADGGADLPLEKFVQVNLCRLAPVTDAPTGCRPCPRWSRVGRNPGASIVRNAHRRDLTLADTGGAKSGGIQGSSTVRNALPRLATEVGRVQFAVVAGPGRRRAEHSHGRTAGIRGRLRSGFRDRVRWSTVALPGSSGRWPVGGAVVPEPAVRGRRCPAPPRVMLASGGPGDGRRNRRAHRCAAGGRLWARGHRAGIAAPRPAARAAGRRPGRRPRPTRCAHPGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YW35</accession>
    <name>A0A1H5YW35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27456">
        <property type="protein sequence ID" value="SEG27456"/>
        <property type="gene ID" value="SAMN04489712_104179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG27456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="28424" checksum="32C322A629D69867" modified="2017-01-18" version="1">MSIQEFIVYRATAGPDVDTVIGLIDEASQWLRLKDTDQWARPWPDEESRRQRILDGLRTGTTWIVRDGTVPVATVSMTDEGNPLLWRPDELAERAVYLHRLVISRKYAGHGLGAALLEWAAQEGRREYDATLLRIDVWRDNLDLHAYYRRLGFRPPNGSAEPEIRVDKERWPSGAVFQRRIPDARTYRKNQKIRFTLVENASQAPDAERPMESPRHPSGTRPEPILAMATGMLLTAVNLLPLISRHPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXN8</accession>
    <name>A0A1H5YXN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA integrity scanning protein DisA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">disA</name>
        <name evidence="12" type="ORF">SAMN04489712_104239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DisA family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28808">
        <property type="protein sequence ID" value="SEG28808"/>
        <property type="gene ID" value="SAMN04489712_104239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01438">
        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="10"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG28808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="361" mass="39277" checksum="CA7C09F2358A08F4" modified="2017-01-18" version="1">MGVIHDKGHDERRRATLAAVAPGTALRDGLERILRGHTGGLIVLGYDPVVAELCSGGFELDVEFSATRLRELAKMDGAIVLDMERSRIVRAAVHLVPDPTIPTEESGTRHRTAERVAKQCGFPVISVSQSMRIIALYLDGTRYVLEDSAAILSKANQALATLERYKLRLDEVSGTLSALEIEDLVTVRDVTSVVQRLEMVRRIADEIEGYVVELGTDGRLLSLQLDELVSGVDVDRELIVRDYQPPETPARVVGEVLDALDALSANELLDLTTVAEVMGYSGPDALDIPVSPKGYRLLAKVPRLPGLIVEDLVEHFGGLQKLLAAGIDDLQSVDGVGESRARSVREGLSRLAESSILERYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YYT3</accession>
    <name>A0A1H5YYT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">SAMN04489712_104217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28326">
        <property type="protein sequence ID" value="SEG28326"/>
        <property type="gene ID" value="SAMN04489712_104217"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG28326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="27863" checksum="EEADE2ADB0712A77" modified="2017-01-18" version="1">MLLTIDVGNTNTVLGLFEGEEVIEHWRINTDARRTADEIAVVFQGLISQSPLLADTDISGIALCSTVPSVLHEMREMCRRYYGDVPAVIVEPGVKTGVPVRMDNPKEVGSDRIVNALAAIHLFGGPAIVVDFGTATTFDAVSAKGEYVGGAIAPGIEISIDALSARGAQLHNVELARPRSVIAKNTVEALQSGIIFGFAGQVDGLVDRMSEELTANPDDLTVVATGGLAPLVLDEARSIDVFEPWLTLIGLRLIYERNIGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z5E2</accession>
    <name>A0A1H5Z5E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31240">
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        <property type="gene ID" value="SAMN04489712_104347"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG31240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="158" mass="18136" checksum="C58E16845C715F2B" modified="2017-01-18" version="1">MTMVEMEQVEQVKDPRTLVTPEMFEQMVDDVVVFDKVTRPYAEAGVEQFLVFLKAWGDTMREVGGDPRAWVKFAPSPAVDKIWHRSMMRTRNFEAVCEMVAGRYMHHLPIMDEDIRSGAASERGLTAMRATGYRVDLEWWMDGESCCPENCAQPPLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z650</accession>
    <name>A0A1H5Z650_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31848">
        <property type="protein sequence ID" value="SEG31848"/>
        <property type="gene ID" value="SAMN04489712_104381"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291307" evidence="2">
        <location>
            <begin position="34"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG31848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="28705" checksum="B49649F24A7D82BA" modified="2017-01-18" version="1">MNRRADRIIAVAAVAAVAVVPTVLLVAIKAGQADPKAPGELPSAAAYRPGPTASRTPSAPPSIAAFVPAGTGTPVPPTGGPSATPTAEPFTVNSFTRTTDGRLRRKIDGGGERVNEASRVVLAPRFGQSTEGLHERTVGQETTSSPLRVLIKGDTLSAFDGTKWTKTKLTERQLAQMKAASDPRLITFTVASLPGATRKGPNAAGLTRYGGASTVGQMVGFLPQNLADEVLKTVPPDTATKVEVVADGKGCPSLFTMLVDERTVTVTVRSTFGTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZFJ9</accession>
    <name>A0A1H5ZFJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34515">
        <property type="protein sequence ID" value="SEG34515"/>
        <property type="gene ID" value="SAMN04489712_104502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291496" evidence="1">
        <location>
            <begin position="32"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="3">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="159"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG34515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="522" mass="57459" checksum="CE85A2F08DBD77B6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZUJ5</accession>
    <name>A0A1H5ZUJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40203">
        <property type="protein sequence ID" value="SEG40203"/>
        <property type="gene ID" value="SAMN04489712_10521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291961" evidence="2">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG40203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="6164" checksum="95A2FB90E309E2D9" modified="2017-01-18" version="1">MLSKALLGLVKSLLAFVAALTPSSVPAVAVVAAVGTTVAVTAGCAAEDDGDDDDDGGDNDGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1X9</accession>
    <name>A0A1H6A1X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41736">
        <property type="protein sequence ID" value="SEG41736"/>
        <property type="gene ID" value="SAMN04489712_10596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="24"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG41736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="25707" checksum="84F3642C61F8D9FE" modified="2017-01-18" version="1">MDARIEQVVSKGKCTLDDTEYEVESNTYIVGDDDEVIVIDPAHDAEGVLKAVGDREVMAVICTDGLDSHLNSVLEVAAAGEDDEENWAPIALHRNDRILWRDYFAQLAKEEDDPEDAKALRSLEPDIWLEDGGVFEIGGVQLEIQHTPGHTPGSVIVYCEQLSVLFSGDTLHRGRPGSVGGVFSDLRRQLNSIGSLLTPLPKDIRVLPGQGGETTVGDEDARWESWGALARETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A643</accession>
    <name>A0A1H6A643_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43921">
        <property type="protein sequence ID" value="SEG43921"/>
        <property type="gene ID" value="SAMN04489712_105223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG43921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="130" mass="14569" checksum="4F2E6E5A0B2DD283" modified="2017-01-18" version="1">MALKPLELTYVQFVLLEGLWRFDVQGRYPSQRELADQASTDVMMTSQVVRVLEDKGLLRRAVDPRDARKRVLTITDEGRKLAEEAVQVVRDTDDGYFAGIPDRGALLGVLSRLAFPGEWRPARDGGPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A8F8</accession>
    <name>A0A1H6A8F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44325">
        <property type="protein sequence ID" value="SEG44325"/>
        <property type="gene ID" value="SAMN04489712_105246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="31734" checksum="51FDDC42A4C97087" modified="2017-01-18" version="1">MKIIRRDNGRNHWYIDTETGDRIPGVTTILGDGLPKKALINWSANATAEYAVDHWDELAELPPSARLKKLQGGRYEAKDEAANRGTQVHKMGERLIAGESVVVPDLLRPYVESYVRFLDEFQLRARYVEAVVYSASHRYVGTLDIFGDILLPDMPEYEHLPRDEDGFVCDVLIDAKTNRSGIFGETALQLAGYRFAEFMQPDPKDPDTAIPMPDVTWTGALWIRPDGYSLIPVTAGPEQHRAFLYVQQVGVFDRGARDLIGEAIEPPTASRYVLAKAGEADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AA97</accession>
    <name>A0A1H6AA97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45282">
        <property type="protein sequence ID" value="SEG45282"/>
        <property type="gene ID" value="SAMN04489712_105294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG45282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="61" mass="6909" checksum="0A0B2731A73BA1F1" modified="2017-01-18" version="1">MDRDERRRISERAAAFGVWLDNLPKVGHPDHGDPEIAERALAAFEERRPGARGEQDEQPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AAL0</accession>
    <name>A0A1H6AAL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="9" type="ORF">SAMN04489712_105300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45402">
        <property type="protein sequence ID" value="SEG45402"/>
        <property type="gene ID" value="SAMN04489712_105300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="127"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="313"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG45402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="43808" checksum="743C4487459F55C4" modified="2017-01-18" version="1">MAMETSAESPVPVRTVLNAVSGWVGRLGRIWVEGQITELNRRAGTVYLTLRDPVANMSVRVVGPRAVFEAAGPAVTDGARVVVHAKPDFWVNRGTFSLSALEVRPVGVGELLARLERLKQVLAAEGLFRPERKRPLPFLPGTVGLICGRDSDAEHDVLQNARRRWPAVRFRVENTAVQGSHAVGEVLEALRGLDADPQVEVIIIARGGGAMEDLLPFSDEALVRAVAAARTPVVSAIGHEQDSPILDLVADVRASTPTDAAKKVVPDVREQVQLVRQLRDRGRRCLSGRVERERAWLEATRSRPALADPVREVERKAEQVLALRDRARRCLSGALDRAGDQLSHTRARLLALSPAATLDRGYAIVQRPDGAVLRSAAEAEKGGELLIRLPDGRLRTTVEGPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ACD2</accession>
    <name>A0A1H6ACD2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Beta-thionase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Serine sulfhydrase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_105345</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homocysteine + L-serine = H2O + L,L-cystathionine</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46131">
        <property type="protein sequence ID" value="SEG46131"/>
        <property type="gene ID" value="SAMN04489712_105345"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="336"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG46131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="455" mass="48675" checksum="729950CA4FD0229D" modified="2017-01-18" version="1">MRVHDSLTELMGDTPLVRLRKVTEGLAPQVLAKVEYFNPGGSVKDRIAVRMIDAAEASGRLRPGGTIVEPTSGNTGIGLAIVAQERGYRCVFVCPDKVAQDKIDVLRAYGAEVVVCPTAVAPDHPESYYSVSDRLAAEIPGAWKPNQYANPHNPRSHYETTGPELWEQTDGRITHFVAGIGTGGTISGTGRYLKEVSGGRVKIIGADPEGSVYSGGTGRPYLVEGVGEDIWPETYDRDVCDEILAISDKDSFTMTRRLAREEALLVGGSCGMAVVAALRVAERAAPDDVIVVLLPDGGRGYLSKIFNDDWMASYGFLSTPTEEARIREVLARKNSGLPQFVHVHPYETVEAAISVMREYGVSQLPVMKEEPPVMAAEVVGAIRESDLLSALVSGHAKLADQLDVHMAEPLPMVGAGDPVSKAVGVLEKAGAAVVLDDGKPTGLITRQDLLAYLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADC8</accession>
    <name>A0A1H6ADC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NitT/TauT family transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_105361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46382">
        <property type="protein sequence ID" value="SEG46382"/>
        <property type="gene ID" value="SAMN04489712_105361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="95"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG46382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="294" mass="31797" checksum="C1AB603B2F1793C5" modified="2017-01-18" version="1">MALETRKPGTGRSPDVNRELAGLDALELAAGARRSPLSRLWSAVWPMLVAVAIALGAWELVVLSGWKEPWVLPGPRDVLPEFWNVVTDGRFWDAVGLTMQRAVIGFAVATAIGVLIGAVVSRSMILRRAFGSLITGLQTMPSIAWFPLAILLFQLSESAILFVVVLGAAPSIANGLITGVDYTPPILLRAGKVMGLRGLGLYRHLIIPASLPSFVAGLKQGWAFAWRSLMAGELLVIIGDTQSVGTLLHFARELSDTERMISVMIVILIIGILVDQLFALADRTLRNRWGLNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AFQ6</accession>
    <name>A0A1H6AFQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">SAMN04489712_105399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47080">
        <property type="protein sequence ID" value="SEG47080"/>
        <property type="gene ID" value="SAMN04489712_105399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="99"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG47080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="21645" checksum="D675F41EE0058B0C" modified="2017-01-18" version="1">MSEVRIAAEPRTEFGKGAARRTRRAGKVPAVLYGHGTAPQHITLPGHDLMLALKTPNVLLRVQGLADGDALALPKDVQRDPIKGFLEHVDLLLVKRGEKVTVEIPVNAVGDVVAGGRLEQPVIQLAVEAEATHIPEAVEVDITGLEVGASLLAGDLKLPSGADLAADADTLILQIVDATVATGEVAEAETAEAAEGAEPAAEAGEGTSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AUT6</accession>
    <name>A0A1H6AUT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52281">
        <property type="protein sequence ID" value="SEG52281"/>
        <property type="gene ID" value="SAMN04489712_10619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="713" mass="75580" checksum="99692E62F11298D5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXA5</accession>
    <name>A0A1H6AXA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-formyltetrahydrofolate cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52436">
        <property type="protein sequence ID" value="SEG52436"/>
        <property type="gene ID" value="SAMN04489712_10631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="PTHR13017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="215" mass="23434" checksum="92B678CCDF8A806A" modified="2017-01-18" version="1">MDIKQAKQEVRERIWDLLEREKAVREPGVHGHIPDFIGSERAADLLATLPAWKSAQVIMCNPDRAQLPVRIRALEEGKLVYMAVPNLADEHPFYELDPTKLSLPPSEAATSKVAATVAPKVNVDTIRPIDLFVCGSVAVNRDGARLGKGAGYSDIEFALVRESDLIGPGAVVVTTVHVLQVVDGPLPESAHDFRVDFIITPDVVAVCDTPFAHNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXQ7</accession>
    <name>A0A1H6AXQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerF vWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53070">
        <property type="protein sequence ID" value="SEG53070"/>
        <property type="gene ID" value="SAMN04489712_10671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019303">
        <property type="entry name" value="vWA_TerF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10138">
        <property type="entry name" value="vWA-TerF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="37"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="25764" checksum="BC534D4AEF821439" modified="2017-01-18" version="1">MPISLDKVRSTAPGLVGLYQAAKVNLDKRGLGGERAAVYLVLDRSGSMRRYYKDGTVQHLAEQALALSAHLDDDGVVPVVFFDKVAYPPVEVGLTRYQGRINEEHERLGHMGTTNYAAAMEAVIDHYRAAAPAAPAFVIFQTDGSPDSRTAAEKVLCEASTLPLFWQFVGFGDDEFKFLRKLDDLPVPRKRAIDNAAFFPAGPDPRGIADDDLYRHLMDEFPAWLAAARAAGILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B0F6</accession>
    <name>A0A1H6B0F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53767">
        <property type="protein sequence ID" value="SEG53767"/>
        <property type="gene ID" value="SAMN04489712_106115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293195" evidence="1">
        <location>
            <begin position="29"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="36175" checksum="2AD24E22D01F8DA6" modified="2017-01-18" version="1">MRVVAAVVVAVALVMGGAALRSSGSREADGSLTADEQRSLATLRVVDARHPLLAMTLYAPYDPLRPVVAAPATERPLACSLFLARRGPRGPVFGRNFDWLGNPALLLTTRPPRGPASISLVDISYLGITHAKASRVTRDPVLRRKLLQAAALPFDGMNEHGLTIGLAQIPDAEPPRVPGRPTVGSARIQRLVLDQARTVDEAIAVFGRYNVEFAPGEPALHYLVADARGRSAVVEFVDGRVKVIRGTGSWQGMVNFVLSGAGEDVKRSDDRYRTIAERMRATGGGLSPAGAMDLLAAVAQRHTRWSAVYELHHGTVHVALGRDYHKRYTFSLKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BDX5</accession>
    <name>A0A1H6BDX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">SAMN04489712_10728</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58870">
        <property type="protein sequence ID" value="SEG58870"/>
        <property type="gene ID" value="SAMN04489712_10728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG58870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="17767" checksum="5E5E382BD62D1308" modified="2017-01-18" version="1">MPDAAEPRRPPVALPVDPDVDLHVPAQRAELARAPWTTLGAVSAGGVVGALARHGLAAAWPHPPGGFGWAIFAVNVTGCLLIGVLMVVITEVRQAHPLTRPFLGVGVLGGFTTFSTYVLEAQAALDAGAPRTALAYLAGTALAALAAVVTGVRVTRRLAGRAGTRRTADQGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BEY6</accession>
    <name>A0A1H6BEY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Autotransporter family porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58925">
        <property type="protein sequence ID" value="SEG58925"/>
        <property type="gene ID" value="SAMN04489712_10733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG58925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="6694" checksum="3F8BD7759FF73B5E" modified="2017-01-18" version="1">MLRTPLAPRAVHPSPVPTPPPQPDPVPAPQPRPPGPIPDPQPVPEPAPGPPVPQPDPEPVGGAAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BP17</accession>
    <name>A0A1H6BP17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62433">
        <property type="protein sequence ID" value="SEG62433"/>
        <property type="gene ID" value="SAMN04489712_107296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025289">
        <property type="entry name" value="DUF4081"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016794">
        <property type="entry name" value="UCP21603_acetyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13312">
        <property type="entry name" value="DUF4081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021603">
        <property type="entry name" value="UCP21603_acetyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG62433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="30614" checksum="B69732C4E6FB206A" modified="2017-01-18" version="1">MLGSMPVRVLDDRHRDRVLTILDSDPVSNVFVSSRVHAVGLDPGRLGAQMWGYIRDGRLSALCYSGANLIPIAADSEAVRAFAERARTQGRRCSSIVGQIEAVTELWELLAPYWGRPRAIRASQPVMATSRPSPVPPDPGVRRVRMEEFDIVYPACVSMFTEEVGVSPNVGDGGALYRARVAELIRAGRSFARIEDGRVVFKAEIGAATPHACQVQGVWVHPDLRGRGLSVGGMAALVDESLRTIAPTVSLYVNDYNARARAAYRRVGFTEVDTFMSVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPA9</accession>
    <name>A0A1H6BPA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62520">
        <property type="protein sequence ID" value="SEG62520"/>
        <property type="gene ID" value="SAMN04489712_107302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG62520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="154" mass="16548" checksum="5F4F8405BE3C6E5E" modified="2017-01-18" version="1">MKQITVIVDIAPATPYHPAVIALCAEQQAEIEARYPGAGEAPSGIDPQIDFLLARVGDEPVGCGGLKPLEPRVAEVTRMYVRPAHRGQGISRGLLDALEGLAGGRGVRTLRLETGDLQPESIGLYQSSGYRRIPAFGPYQGNALSLCFEKHLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPC0</accession>
    <name>A0A1H6BPC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_107286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62285">
        <property type="protein sequence ID" value="SEG62285"/>
        <property type="gene ID" value="SAMN04489712_107286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293950" description="Histidine kinase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="169"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="229"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG62285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="440" mass="46341" checksum="A274259650F8DAD8" modified="2017-01-18" version="1">MRRALGLVALAVTAMVALAFLIPLAFTVREITRDRALNAAEREAASMGPVLSLSIKPGDVERAMSATETGASGRMSVHLPDGTVFGTDRADAEAVTEAARRGGVSTVEVTGGHVVLQPVALADSQVAVVEVFLPGGELTQGVWSAWLAMAAVGVVLVAGSVVAADRMGTRVVRATQRLADAAAALGEGDLSVRIEPEGPPELVEAGFAFNAMADRVTQLLAAEREMAADLSHRLRTPLAALRLNVEALDAGPVGDQTRDAVDQLEREIDLIIRAVRTPTGRGSCDAARVLRERVAFWSALAEDEGRNCELIGADQKAPVPLPAAELEAAVDALLGNVFRHTAEGTDFVVTLHVGEGVTGILVADAGPGIDDPEAALERGRSSRGSTGLGLDIARRAAESTGGYLRIHRSVLGGAQIQIWLRTGERPTPRRSRRSRRRQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUG8</accession>
    <name>A0A1H6BUG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Copper transport outer membrane protein, MctB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64348">
        <property type="protein sequence ID" value="SEG64348"/>
        <property type="gene ID" value="SAMN04489712_10816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021522">
        <property type="entry name" value="MctB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11382">
        <property type="entry name" value="MctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG64348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="319" mass="32678" checksum="CF55924B6DD5C25D" modified="2017-01-18" version="1">MIDFRYHLVSIVAIFLSLAVGLVLGATALSDPLLGTLKKESNAAIKRSEELRARQLELLKQIEGEEQFSRTVARQLLAGRLKDQSVVLVETPGAGQESLNKISELLGEDAAGATVTGRVTIQKKFLDDDQLATLDQLAEQLRPAQMKFSDGAGPYDKAGQVLAAALLTGDSAKALRDDASGKATLEAFKSAGFVTVSGKPAQHATLAVMVAPSSPYQDGADVDNRALISLAGALDSAGRGTVLAGPTTAAGEGGLIAALRESDAADEVSSVDVIDQSSGQVVTVLALESQIAGKTGHYGTGEGAGAYLPTPAPAPGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7I8</accession>
    <name>A0A1H6C7I8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ORF">SAMN04489712_10927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68873">
        <property type="protein sequence ID" value="SEG68873"/>
        <property type="gene ID" value="SAMN04489712_10927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG68873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="12915" checksum="8574D3C3188C1D56" modified="2017-01-18" version="1">MHEMGLCEAIVDATLRRAGGRRVSAVRVRATGHPVDPGVVEQGFRLAAAGTVAEGAALDLVVEPPAVRCRSCDETSPVTTATALAACPRCGGLDVTVPAGDGLVVESIATTDNEPASARGGGRRGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C857</accession>
    <name>A0A1H6C857_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69083">
        <property type="protein sequence ID" value="SEG69083"/>
        <property type="gene ID" value="SAMN04489712_10947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="125"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG69083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="30468" checksum="ECDFC3407813E7AC" modified="2017-01-18" version="1">MNGRARGRGGRLAVLTAGLVIALLAGVLVPWPSHGYEDAVSAAPTGLVPLEESRSAALTRSVAGYLAGREGGRLSVEVRDLATGTFYAYGSSQRFPTASIVKADILAALLLQAQQARRDLTEEERELAARMIRKSDNASATTLWNAIGGAPGLTRANQTLGLTETTPASGGYWGLTSTSAHDQVRLLSVLAAGDGPLDARSRAYALSLMSSVSAGQDWGVSAAAPGSPVALKNGWLPRTADDGRWVVNSIGRVRTGTHDYLIAVLSDRSPSLKKGITTVEHVTKLVTRSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8M4</accession>
    <name>A0A1H6C8M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68985">
        <property type="protein sequence ID" value="SEG68985"/>
        <property type="gene ID" value="SAMN04489712_10938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="15852" checksum="EE6F6B2934D15B25" modified="2017-01-18" version="1">MSESPAIVWQAPDGDHPARRAAQRSMAAAIAGRKEDWLALFAPDALVEDPVGPSMLDPTGKGHHGHDGIGKFWDDHVSTVRAFHFHVADSFANGPCCANVTTITTTLDGGTTMTIDCVIVYTVDDTGLITSLRAHWEPDRAMATLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9T1</accession>
    <name>A0A1H6C9T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multisubunit sodium/proton antiporter, MrpE subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69126">
        <property type="protein sequence ID" value="SEG69126"/>
        <property type="gene ID" value="SAMN04489712_10952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG69126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="174" mass="19042" checksum="837D2917626242F7" modified="2017-01-18" version="1">MKIRLTSRLVMAVWLLAVWLALWGRADATTVIGGCVLVVLVGLATRLPALPIFSRVHPAPLARALVAFTADLVVSSVVVGWYALRRTASVRGGIVAVRFRSGTDVTLLMVAHSVSLRPGSLVVDVDRPGSLLYVHGMPIHGERDAERVRREVLDTEHRIMRAFGPPRPGEEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCX1</accession>
    <name>A0A1H6CCX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_109199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70748">
        <property type="protein sequence ID" value="SEG70748"/>
        <property type="gene ID" value="SAMN04489712_109199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1710"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1809"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG70748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="2171" mass="228499" checksum="701EA8D3512ADD40" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJE7</accession>
    <name>A0A1H6CJE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gas vesicle structural protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72893">
        <property type="protein sequence ID" value="SEG72893"/>
        <property type="gene ID" value="SAMN04489712_11047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG72893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="28183" checksum="764B32CF6139D150" modified="2017-01-18" version="1">MRGRPSQGSVVPSSSYYGGGVSHREPANLGDILERVLDKGIVIAGDIRVNLLDIELLTIKLRLLIVSVETAKELGIDWWEHDPWLSGKQRSLEEENRRLRRRLAAVEDGEREDLELRPPRRQPAEERGIESEDYLAESEDRRARSRPYRTEPEDPRARSEDYWADPEDYWAERERRRAGPETRRAGAQDYRDGPENYQPRSRDRRAEQEDYRAEPQGRRGGARDDWAEQEGYRSRSEGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJM9</accession>
    <name>A0A1H6CJM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73132">
        <property type="protein sequence ID" value="SEG73132"/>
        <property type="gene ID" value="SAMN04489712_11075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG73132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="401" mass="44177" checksum="5AE92A4A6A0C2639" modified="2017-01-18" version="1">MESARVVAGLARLLHDVGLAEELAQDALVIALEQWPQSGVPDNPGGWLMLTARHRAIDLIRRNARYTDKLAEVGRDLAVRQESAEAELIDELDDHIGDDLLRLLFTACHPVLPAEGRVALTLRLLGGLTTQEIARAFLVPEPTVGQRIFRAKRTLADKGVRIELPPPDELPGRLASVLEVIYLIFNEGYSATAGDDWTRPSLCEEALRLGRVLAGLMPDQAEAHGLVALMEIQASRIRARTGPDGEPVLLLDQDRRLWDRLLIRRGLAALARAEELGTLGPYGLQAAIAACHARAVTPEDTDWERMAALYRVLAHVAPSPVVELNRAVAVGMAYGPARGLEIVDALVRERALRSYPQLPAVRGDLLEKLGRLDEAREEFRRAADLTRNERERALFLARAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CK65</accession>
    <name>A0A1H6CK65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">SAMN04489712_11096</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73318">
        <property type="protein sequence ID" value="SEG73318"/>
        <property type="gene ID" value="SAMN04489712_11096"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="47"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="173"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEG73318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="341" mass="35359" checksum="DD3AB9706D853A57" modified="2017-01-18" version="1">MTSYEAAGVDIAAGERAVELMKARVAGARRPEVVDDASGFAGLFDASALLKYRRPLLATSTDGVGTKVDLARRLGVYDTVGHDLVGMVVDDLAVCGAEPLFMTDYIACGKVVPERIADIVGGIAEACALAGCALVGGETAEHPGLLEPDEFDIAGAATGVVEADEMLGPDRVRPGDAVLAMASSGIHSNGYSLVRHVLRGSELDLASEPADLGRPLGEELLTPTRIYAQDCLALARAGGVRAFAHITGGGLAANLARSLPPGVDARLRRSSWTPPAIFAVLQEYGRIPQPEMDKTFNLGVGMAAVVAPDAADAALRLLDERGVPAWVLGEITEGTGNAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKW2</accession>
    <name>A0A1H6CKW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_110135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73639">
        <property type="protein sequence ID" value="SEG73639"/>
        <property type="gene ID" value="SAMN04489712_110135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG73639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="34743" checksum="316A64F1FF99AF31" modified="2017-01-18" version="1">MLTLRSLSVGYPGRRGRPSRRVLSGLDAVARSGDLTVLIGPNGTGKSTLLRTLAGLQPALEGDVLLDGSPVTAIDAAELARRVAVVLTERDLPALLTARELTGLGRHPHTGFTGRLTAADHAVVAWALDAAGAAHLAERPVTELSDGERQRVLTARALAQEPAAILLDEPTAFLDVPSRVALMGLLRRLARERSLVVVVSTHDLELALRIADRIWLVDPGGALRCGTPEELTLDGAISTSFDGDDLSFDAASGVFVLHGGGSGTALVTADGVRGPLLERALTREGWRPAAGPPADLTVTWTGDAYEAALNGTTHRFTTLAALTDWARRPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNC0</accession>
    <name>A0A1H6CNC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74519">
        <property type="protein sequence ID" value="SEG74519"/>
        <property type="gene ID" value="SAMN04489712_110236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="69" mass="7958" checksum="982F3273B94CF7D3" modified="2017-01-18" version="1">MTVDTQVRPAIYVGQERMAIAPAPKLAQWERDLIERLELEWDLHKIESMHPDETISGSGDGWDDCDYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CPE8</accession>
    <name>A0A1H6CPE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74495">
        <property type="protein sequence ID" value="SEG74495"/>
        <property type="gene ID" value="SAMN04489712_110232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG74495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="21843" checksum="9D676455F5A6CE9F" modified="2017-01-18" version="1">MNATSSFLSDRSELTDRTVTVVPMARSSTGLRDRLLASALRLFIQHGFRGTSLADIASDVGCSKASLLYHFSNKEAILAELLLPVGREAAALDARLAGLDGAEAAVTAVTGFVDITLRFRREIKLLFDNLTDATSLSEMGLEGVEGIGDRLIDAVAGRSTEPRDRVAGLMAVSGMFVTGAADLPFDEETLREAMVAGALRTLGRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUJ3</accession>
    <name>A0A1H6CUJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_111119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76076">
        <property type="protein sequence ID" value="SEG76076"/>
        <property type="gene ID" value="SAMN04489712_111119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG76076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="360" mass="36638" checksum="9D6CA5CC48F36E71" modified="2017-01-18" version="1">MTDIAEPRTSGGVAITAPRRPRLPYPLVLPVLAALVAVAATAGIAAGSVGVPAGEVWGILAHRLHPALADPTWTPVRETIVIDVRLPRVLLCGVVGAGLSVCGMALQALVRNPLADPMLLGVSSGATVGAVVVVVFGLTLFGPFSLPLAAFCGALAALVAVYLLAHSGGRMTTVRLVLAGVATAEVLSAVASYLVVTSDDPHAAESALRWMLGGLGGTTWDLLPIPAAAVLAGTAVLLGVSRPLNLLLAGEEAAAALGLTVHRFRAAMFVLVALMIGTMVAVSGSIGFVGLIMPHIVRLLVGADHRRALPAAALLGAAFLIVADLAARTLISPEEIPVGIITALVGGPFFLWLMRRRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUQ1</accession>
    <name>A0A1H6CUQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76578">
        <property type="protein sequence ID" value="SEG76578"/>
        <property type="gene ID" value="SAMN04489712_111181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG76578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="30789" checksum="C1C28FC4FE1B5DCF" modified="2017-01-18" version="1">MPREGETPTGPDRSGLRADCANCFGLCCVALPFAASADFAADKAAGQPCANLRADFGCGIHAHLRERGFPGCAVFDCFGAGQQVSQITFGGRDWRRNPHTASRMFEVFPVMRQLHELLWYLAEALALPPARPVHADLRRVRDDIDRLTHGTPETLVELDVAALRADANALLLRASELVRAKIPGRRRNHRGADLIGARLSGADLRGANLRGAYLIAADLTNADLRTADLIGADLRGADLSGADLTGSIFLTQAQLNAAKGDAATRLPRTLVHPAHWRPARKAAGSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CXF4</accession>
    <name>A0A1H6CXF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77185">
        <property type="protein sequence ID" value="SEG77185"/>
        <property type="gene ID" value="SAMN04489712_111260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG77185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="755" mass="81937" checksum="E93B4F5249E03AA2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5I0</accession>
    <name>A0A1H6D5I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80562">
        <property type="protein sequence ID" value="SEG80562"/>
        <property type="gene ID" value="SAMN04489712_113103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="111"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="24100" checksum="430F5362A0D0C151" modified="2017-01-18" version="1">MHVHPFLQTRLHLHNIGSKIANTGHRQPLGFFAMILDQADDATDMPAREGRRHWWLSALDQSPRPPGHWPIPPAGSPRTARLVLRTEAGSPRAAREFTARTLGDWELYDPSDDVTMVVSELVTNAVRYGLDGLPPAAQLCPVQLALFGHPRRLVVVVTDPSDHIPQAAEPGADRISEFSERGRGLLVVQALSSAWGWAPLTSGGKAVWAAFDLRRRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D659</accession>
    <name>A0A1H6D659_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80106">
        <property type="protein sequence ID" value="SEG80106"/>
        <property type="gene ID" value="SAMN04489712_11314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="106"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG80106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="28620" checksum="B392EEB253CB7DAB" modified="2017-01-18" version="1">MSLAHRCGHVITFGGEEEFAGPITNGGEVVSTAVQTARRTGSAGAIGRAMTVLNCLGRRAAPTSLAEISRRTGLPKSTVHRLLGTLEGQGAVRRAGAGYVLGEAIRRLSDGVETAHRDALRHLLMPHIAELYEATRLPTSLAVLDGHSVVRLVTLYPRTPGGPVPHGTGRVPADRTALGRLLLAYRPEPAALEPELVSIRRAGIAFLGREPAGGLAEMAVPVAAWPDREVAAIGLTGRSGELARTGVERLLRRTALEARLTLRRHRAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D856</accession>
    <name>A0A1H6D856_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81490">
        <property type="protein sequence ID" value="SEG81490"/>
        <property type="gene ID" value="SAMN04489712_11469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="TetR_C_1" evidence="2">
        <location>
            <begin position="77"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="188" mass="20171" checksum="39E56152C9E6E0A8" modified="2017-01-18" version="1">MVRQPSVAAQNREPLSRDRIIEAALHIVDGQGLGRLTMRRLGDALEVEAMAIYHHLPRGKEELLDGLVAHVAVHPAPTRAAGDWQAVLRRWAGDYRARLLTHAGVLPLVVTRRNPAALGGTAASLREVLRQAGLTEQAAADGAHALLGYVIGHAALEVRGSAAAEEAVDWDTRFTAGVDLVINGLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D985</accession>
    <name>A0A1H6D985_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81860">
        <property type="protein sequence ID" value="SEG81860"/>
        <property type="gene ID" value="SAMN04489712_114160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="13344" checksum="2056ACC6EE85E8BF" modified="2017-01-18" version="1">MTDIPVGTRRADGAWLIRNDVGPLAHRYGSWATLHRTDLLTLLHRALPPEVLQASVQVDQVRPDGTVVHTGGTSGADVVVGADGQRSGTRRSLWPDAVLQHDTYELPDLSTYAADRARRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DD00</accession>
    <name>A0A1H6DD00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_115162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83171">
        <property type="protein sequence ID" value="SEG83171"/>
        <property type="gene ID" value="SAMN04489712_115162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="73"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="177"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG83171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="386" mass="44215" checksum="1CCC2988BD26176C" modified="2017-01-18" version="1">MADGKRPRQRANGEGTIYERKDGRWEGAAYVLTTDGTYKRVRMYGKTREEVHGKLVEAQQRSNRGVPVADKPWKLGEYLDYWLEHIARPSTRWNTYKKYEQTVRLYLKPGLGKQRLDRLRVAKVQTFLNEQIKAGHSVANVHIMRMVLGAALTRAMREELITVNAARLTTLPPTPGRKVKPWSADEARAFLAAARTERLYPAFVLLLVYGLRRGEVLGLSWDDIDLDEEVMRIEWQMQRVDGQLTRTPVKTAAGRRHLPLLPIAREAVIELAERQMFARRRAGDDWEETGLIFTTRNGRPVEPRNLARVFERICDRAGLRRIRLHDLRHTSASLLKKMGVPPSDAKEILGHARISVTLEIYTHGDSESHRDGLGRVAGELFGDRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEP5</accession>
    <name>A0A1H6DEP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83769">
        <property type="protein sequence ID" value="SEG83769"/>
        <property type="gene ID" value="SAMN04489712_11664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="260" mass="27595" checksum="0A44D70FA11BD597" modified="2017-01-18" version="1">MRYDDLPGELSVESDGPVRTVVINRPAELNAVDRPLHWALANVWQRLARDTEARAVILTGAGRAFSAGGDLGWITSFLDDPVARDESLREGAQIIEEMLRFPLPVVAAVNGPAVGLGCSVALLCDVVLISETAYLADPHVAVGLVAGDGGAAFWPLLTPILRSREYLYTGDRIPAAKAVELGLATRTTAPGDLLPEARRLAARFAAQPVEALRATKRVVNMHLSQALAGPLQAGFAAEAATMRSPEHRARLLALKAKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEP7</accession>
    <name>A0A1H6DEP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_115167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83193">
        <property type="protein sequence ID" value="SEG83193"/>
        <property type="gene ID" value="SAMN04489712_115167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="69" mass="7468" checksum="54D963B63F1BC2B8" modified="2017-01-18" version="1">MSGRDRAGPAVGEVGVQVLYLRAVIRVYGPWTTSQTISADERALAVRRVRYAGDLLADLEARLPRNGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFU0</accession>
    <name>A0A1H6DFU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83545">
        <property type="protein sequence ID" value="SEG83545"/>
        <property type="gene ID" value="SAMN04489712_11618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="180" mass="19675" checksum="5C7C1CBC4C3E84FF" modified="2017-01-18" version="1">MDGQASSYPVRASDGERDRVLRVLSDRVAEGRMSHDTFERRVDQVLAARSRAELDDIVHDLPPRHGMVERLTGLVSSVSAATARIEAAWRAPRLPRFRLPSAGTGRIVVGRAPGCHFVLADLTVSRFHAELYHDEHGWMLADLGSMNGTRVNGWRLTGPAPVRPGDEVGFGNSSFIVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHA7</accession>
    <name>A0A1H6DHA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84610">
        <property type="protein sequence ID" value="SEG84610"/>
        <property type="gene ID" value="SAMN04489712_11734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="94" mass="10372" checksum="A342687EF84C42DE" modified="2017-01-18" version="1">MIKLLRKMGLSSNMMYAAGVASIGISFTSWLTSLKVEHAGLDRADRWGIFVGEWAPTFFALGAALRLEEQWGEGGKEEEARRMGQPARETIPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIZ7</accession>
    <name>A0A1H6DIZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84655">
        <property type="protein sequence ID" value="SEG84655"/>
        <property type="gene ID" value="SAMN04489712_11743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG84655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="26826" checksum="B7EC3D2FC371B54E" modified="2017-01-18" version="1">MTPLPGSVPSYLAELFSLDGRVAVVTGGSSGIGRAVAEALARAGARVVIIARDPQRLADAVAALRGHGCQAEHVAADLSTAARVRAAAEQAAAPFGEPDILVNCAGINLRPPLPDLDDAQWEATMDLNLRAPFLLGQRFGPGMAERGWGRIINVASQQAFRAFGNSGAYGASKGGLAALTRSQAEAWSPHGVCCNTLVPGFVLTPLTAEAAADPARVAAMAARTLTGRNGLPEDFAGAAVFLASPAAAAVTGHALFVDGGFAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DK03</accession>
    <name>A0A1H6DK03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase (Class 3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85431">
        <property type="protein sequence ID" value="SEG85431"/>
        <property type="gene ID" value="SAMN04489712_1182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="2">
        <location>
            <begin position="148"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="46904" checksum="06B2471D176AF9FB" modified="2017-01-18" version="1">MAEKTERAAEKTSDQRPAGRLGDVSVLDWERRLRDEFEAGGLWPPDSLGPTYRELRPYGPVETPGFPVYRDLEEHLLRARVHPDPVVAHVLATCAGYSYSNSETLSMIMARLGLESNHCRMITSFVDSMFICSTAFLIQSRSGKVAILCYRGTELVSPVNWLTVADVAAEPMGYYFGDRRAHVHAGFYRNVRATRYQVMQALKLAQHGESVRTRLPGETDGAAPPALEDGLEVLYITGHSLGGAMAALMTVMLKHERKFGGQHGVADLLRAAYTFGQPMIGDPAFAEACAKNDFLREKLIRYIYDNDIVPHLPPLSTGPFQHFGREYRYQIPNLRRGVFGLSKYFGHTYDNRKGDWKEQESPAGQILSILGTLEIGTLSYVLDKVQVLRSLPLPYSVNDHVPSRYIDALTPHGVPNEFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLI4</accession>
    <name>A0A1H6DLI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_118138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86044">
        <property type="protein sequence ID" value="SEG86044"/>
        <property type="gene ID" value="SAMN04489712_118138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="501" mass="55377" checksum="A8699B0A3B0BF579" modified="2017-01-18" version="1">MGLELTDEPTRREPPSPRSGGPREAVAGTVAGADGRVRRFLRAHWLFLGLLVIGAALRVVTVLGYRTMMWFPDTNGYVRLALEPRPGIFRPIGYSFLLRALEPFHSFGLVVALQHLAGLGIAVMVYALLCRRSAIPRWGAALAAAPVLLDAFQIQLEHMVMSDVLFTTLVTGAVTLALWWRRPGPKATAAAGLLLGLAAITRSVGLPLLVLFTGYLLIRRVGWRAVVAAAVIGLVPVAVYATWFHSVHGRFALSNSSGIFLYARVTTFVDCTRFTPPSGTEELCPEEPLSKRHPAHWYVWAQKGELRDPQMQPWFSAEQEALAGKFARKAILAQPGDYLNTVWQESLIGLRWKRKVFPEPYTYDHYVFDAGDKRYGRVDVETVRRYDSGWSHVRAVEPYSGFLGAYQEHVYLRGPLLGGVLVLGLWGVARRWRRLGGPALLPWTVGAGLFLLPPATVMFDYRYLPPVAPLLCIAAALAFGPARGNGVRNRRGETANEGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPC3</accession>
    <name>A0A1H6DPC3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DhaL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87149">
        <property type="protein sequence ID" value="SEG87149"/>
        <property type="gene ID" value="SAMN04489712_12077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="8"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="535" mass="55279" checksum="40C4430CBB4EBB6F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPS4</accession>
    <name>A0A1H6DPS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_120121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87377">
        <property type="protein sequence ID" value="SEG87377"/>
        <property type="gene ID" value="SAMN04489712_120121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="41860" checksum="46A29515D0492581" modified="2017-01-18" version="1">MTEPEANRLSGAAAIAGIGATEFSKESGRSELRLACEAVLAAIADAGLEPSDVDGLVTFTADTNSEIHVARNTGIGELRFFSRVGYGGGAACGTVQQAAMAVATGIADVVVCYRAFNERSGHRYGLGQANRPLDVGADDAAYAWMTPFGLNTPAQWVAMFARRYMHEYGATSEDFGRVAVVDRRHAATNPAAWFYGRPITLADHQASRWIAEPLHLLDCCQESDGGQALVVVSAERARDLPHPPALVMAAAQGSGNDQHMMTSYYRPEISGIPEMGLVGRQLYAQSGLTPADVGAAILYDHFTPLVLPQLEELGFCARGEAKDFIADGHLEVGGRLPFNTHGGQLGEAYIHGMNGIAEAVRLIRGTSVNQPGDLGYVLVTAGTGVPTSGLVLGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTX2</accession>
    <name>A0A1H6DTX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88728">
        <property type="protein sequence ID" value="SEG88728"/>
        <property type="gene ID" value="SAMN04489712_12267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="47" mass="5164" checksum="6158489E554C75DB" modified="2017-01-18" version="1">MGEVCKGFDQLLRRVAVKPIRADVHDHIALSGRCEPADSAPGFQWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVK1</accession>
    <name>A0A1H6DVK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88615">
        <property type="protein sequence ID" value="SEG88615"/>
        <property type="gene ID" value="SAMN04489712_12244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="10"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG88615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="37976" checksum="FA69661B18E2396B" modified="2017-01-18" version="1">MKTTDPGPLLRVRNLTVTFTERRSTPWRRPGAVTAVNDIDLDIEPGGTLGLVGESGSGKSTTARAVLRLVRPSGGSIEAAGFEVGSFGRRVPIAYRRAVQAVFQDPLGSLDPTKVIGDIVAEPLGIHFGLRGRERDKRVAELLDQVGLASHHGGRYPYELSGGQRQRVNIARALAVEPKLIILDEPVSALDVSVQSQVVNLLEDVQERTGVAYLFVAHDLAVVRHASDRIAVMYRSRIVEEGPADRICERPAHPYTEALLAAVPDPDPARQRLQRERRRELRAAAPAAGPRPATGCPFAARCPHRMPVCAETFPGWTPVPDGGRVACHLFGGEGTARPSDTHPDYQETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVW8</accession>
    <name>A0A1H6DVW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_123102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89480">
        <property type="protein sequence ID" value="SEG89480"/>
        <property type="gene ID" value="SAMN04489712_123102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG89480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23665" checksum="C6298DA61FDB0BE3" modified="2017-01-18" version="1">MSDLLGRDFFDRPVEEVAPALLGQVLAHRTEEGEVALRLTEVEAYAGALDPASHSYRGRTPRNAVMWGPPGHVYVYFTYGMHFCMNLVCGPEGKASAVLLRAGEVTDGRDLAVARRPRSSPRDLARGPARLCQALGIAREHNGLDACAPGSPVRVLTGEPVDPARICTGPRVGVSAAKDVPWRFWIDGEPSVSAYRLHVPRRRRATGRGSALDGSGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWN6</accession>
    <name>A0A1H6DWN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89747">
        <property type="protein sequence ID" value="SEG89747"/>
        <property type="gene ID" value="SAMN04489712_12450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="17214" checksum="5FCDD1D6A2B8CA0E" modified="2017-01-18" version="1">MLPRTYESQNCSIARSLEVVGDRWTLLVIRTAFEGVRRFDDFAARLGMARNVLTDRLNRLCDEGILRRHRYQERPDRYEYRLTRKGVELWPVMMMLLKWGDRYYAADGPPMVVVHRGCGGTLTDRLGCDSCGAALGPSDVEPRPGPGARPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1B9</accession>
    <name>A0A1H6E1B9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Bacterioferritin</fullName>
            <ecNumber evidence="5">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the bacterioferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90796">
        <property type="protein sequence ID" value="SEG90796"/>
        <property type="gene ID" value="SAMN04489712_12741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00754">
        <property type="entry name" value="bfr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00549">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0409">Iron storage</keyword>
    <keyword evidence="5 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG90796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="18972" checksum="6C23361F63576828" modified="2017-01-18" version="1">MEGDKDIIALLNEQLTAELTAINQYFLHAKMQENWGYTRLAKHTREESFDEMRHAERLTDRILFLEGLPNYQKLNPLRIGQTVLEQLESDLAIELEAVARLRPGIELMRSRGDVTSARIFEYILEDEEKHIDYLETEIGLYRSLGEHNYLQRLTGSPEEDGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2P2</accession>
    <name>A0A1H6E2P2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4158 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91988">
        <property type="protein sequence ID" value="SEG91988"/>
        <property type="gene ID" value="SAMN04489712_13159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025296">
        <property type="entry name" value="DUF4158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13700">
        <property type="entry name" value="DUF4158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4158" evidence="1">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="23005" checksum="BC3B95D370E9F9EC" modified="2017-01-18" version="1">MTSVERTAYPQFPKLMMARELHVFYTPSADEAVWARERTDTDDHLLALVVALKCFQRMGRFPKAGEVPDAVVDHVRRCLELGEDAAVVYSSPRTAESHRAVVRTRLGVTRNPGKARKIADRAIRKAARVKNNPPDLINVALEHLVQASLELPAFSTLDEMATRIRAEINAGIFQMIRSRLGWPGGRGWRRCWWWARTARATCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4P6</accession>
    <name>A0A1H6E4P6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92597">
        <property type="protein sequence ID" value="SEG92597"/>
        <property type="gene ID" value="SAMN04489712_13444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="669"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="812" mass="87562" checksum="1EF79FBFAA29F319" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6F8</accession>
    <name>A0A1H6E6F8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nth</name>
        <name evidence="12" type="ORF">SAMN04489712_1387</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93282">
        <property type="protein sequence ID" value="SEG93282"/>
        <property type="gene ID" value="SAMN04489712_1387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="62"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG93282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="27885" checksum="29DD8810AAD76C7F" modified="2017-01-18" version="1">MWGRRTGHTAYALPVPRNAPESRLALVRRARRMNRELAALYPDAHCELDFTNPLELLVATILSAQCTDKRVNAVTPTLFARYRTAEEYASAEREELEKIIQSTGFFRAKANNIIKLGQQLCERHGGEVPGRLQDLVKLAGVGRKTANVVLGNAFGVPGITVDTHFGRLARRFGWTTETDPVKVEHEIGELIPRKDWTVLSHRMIWHGRRICHARRPACGVCPLARLCPSFGEGPTDEKAAAKLVRTGPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6L4</accession>
    <name>A0A1H6E6L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92594">
        <property type="protein sequence ID" value="SEG92594"/>
        <property type="gene ID" value="SAMN04489712_13443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="153" mass="17367" checksum="B34605595E7F24C6" modified="2017-01-18" version="1">MLSMFVAMFATCLIVTARRPARREAQASARYPESMTAVLEPEAEEYLAWLADRHWPADEYLDLEREWLAELDPADLPAVRPCPGCRRHDEDVWPCRMCGLLLHSGCGHGMRRRRVGRPYQTRDMQAEAVIAEWICTNCSSVVGLDLDESADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8Z6</accession>
    <name>A0A1H6E8Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94288">
        <property type="protein sequence ID" value="SEG94288"/>
        <property type="gene ID" value="SAMN04489712_14515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="89" mass="9229" checksum="06CFE7112036CB3A" modified="2017-01-18" version="1" fragment="single">AGTPLGEPLTGHIGAVAAVACTTWQGRLLAITGSGDGAVREWDIGSERPLSVLATPDPLNCLAVAPTGELIVGLSWEVVCMERMGTWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAT1</accession>
    <name>A0A1H6EAT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_14230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG94026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94026">
        <property type="protein sequence ID" value="SEG94026"/>
        <property type="gene ID" value="SAMN04489712_14230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23517" checksum="E872F893C4C924CB" modified="2017-01-18" version="1">MTGGRARLFGGMCMMSVIESVADSTSATLSDRSSTVGEVSGRPLRELIDDRLLDELLARSRDEAGGLRLTGEGSLLGELVKAVLERALEAELTAHLGYGRHSADGRNSGNSRNGAIRKTVQTGVGPVQIAVPRDRAGSFEPVLVPKRAGRVAGGLDDMVISLYAHGMTVRDIVHHLRQVYGTELSAETVSRITDQVLEEVKAWQARPLEAGRFLLMIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EC04</accession>
    <name>A0A1H6EC04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94315">
        <property type="protein sequence ID" value="SEG94315"/>
        <property type="gene ID" value="SAMN04489712_1468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="24810" checksum="AB286C2CB19A9AEC" modified="2017-01-18" version="1">MTELAGKVALVTGGSRGIGAAIAERLARDGADVAVTYTSSADRAAEVVRRIEAAGRRGLALAADSADPVALIGAVERVVAGLGGLDILVNNAGIAPYGPFEQVAVEEVDRALAVHARAAFVAAQAAAPHLEGGGRIIGIGSNLAERLPYPGWTLYAMSKSALIGLTKGLARELGPRGVTVNLVQPGSTDTEMNPADSPDADHERALTALGRYARAEEIAATVAHLAGPAGAYITGTAITVDGGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EC89</accession>
    <name>A0A1H6EC89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv2161c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000054">
        <property type="protein sequence ID" value="SEG94891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94891">
        <property type="protein sequence ID" value="SEG94891"/>
        <property type="gene ID" value="SAMN04489712_1545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="31016" checksum="CFFDD6A4BB8FAF03" modified="2017-01-18" version="1">MRFAISYSTPYYGVDADRLVAYAQHAEKCGFEALYLPEHIALYPGAKVGNLELPPTLPYGDPLDCLSFVAAATERILLGTGVLLLPYHHPVTLAKRLATIDVLSKGRMRLLTVGIGALPGEAEAVGVDFRTRGRRADEAIQVMRSLWAGGEEGVSFDGEFFSFDKLVSFPKPFEATGLPIHIGGSSRAAARRVGRYGDGYFAGGALPADERAAQLDLARSTAAEAGRDPKGLEYTRWGSMDMSAERVEDFAVQGVTRIVVGATATDPEEQRKEMSAFAERFGLLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EDQ7</accession>
    <name>A0A1H6EDQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000055">
        <property type="protein sequence ID" value="SEG94925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94925">
        <property type="protein sequence ID" value="SEG94925"/>
        <property type="gene ID" value="SAMN04489712_1553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="9145" checksum="51057DE5E7080E2B" modified="2017-01-18" version="1">MHYKPLIGLPGVSVHLHATTLCNSIYRGDDQMLVNTHVFGMNAYGAPLWHIRRAPESRMFDVYAESFEAVWELSRPANEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S6J6</accession>
    <name>A0A1H5S6J6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cytochrome bc1 complex cytochrome c subunit</fullName>
            <ecNumber evidence="3 10">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_10192</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 2 heme groups covalently per subunit.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 10"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46004">
        <property type="protein sequence ID" value="SEF46004"/>
        <property type="gene ID" value="SAMN04489712_10192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009152">
        <property type="entry name" value="bc1_cytC-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000007">
        <property type="entry name" value="Ubiq_cycred_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="49"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="175"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEF46004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="32017" checksum="1A815CA0793D2F2E" modified="2017-01-18" version="1">MKRFTAWRRRPWAGYAVVLAALAAIGAIYAGFSPRTDRAEAANAAQAAADLANGRQLYNKNCASCHGPNAEGTKDAKGRPLAPSLIGVGAASVDFQVSTGRMPAMNPGAQMPRKPPIPEFNTNIPTDFHDPAQRARAEQQKAQAEKNLADLRNYIQSLGGGPEVPSAEMVDPQGGDVALGGKLFRTNCAQCHNFVGSGGALTGGKYAPPLSNDNVTPTQIYEAMLTGPQAMPVFNDTTLTPEQKKAIIAYVVQTREEPNPGGNGLGRIGPVAEGLTGWLIGLSMLILAAMWLTAKKPKKLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SER1</accession>
    <name>A0A1H5SER1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49126">
        <property type="protein sequence ID" value="SEF49126"/>
        <property type="gene ID" value="SAMN04489712_101182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF49126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="21074" checksum="BEF887CBA8AA3837" modified="2017-01-18" version="1">MFTGIVEELGEVVAVEPHGDSALLTVRGPLVTEDAVHGASIAVNGVCLTVVETADGAFTADVMKETLDRSSLGVLVPGSRVNLERPVRLADRLGGHLVQGHVDGVGQIVSRRPGERWEVVTVSVPAALSRYVVEKGSITIDGVSLTVVEAGAEHLTVSLIPTTLELTTLGHKGPGDPVNLEVDVVAKYVERLLGPRPEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SKV2</accession>
    <name>A0A1H5SKV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51216">
        <property type="protein sequence ID" value="SEF51216"/>
        <property type="gene ID" value="SAMN04489712_101257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF51216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="20015" checksum="16B0C9F6BF1535DB" modified="2017-01-18" version="1">MTTTTGSRSRPAERPARSRRAVPRRSAGGRPADPPVRPGGPGRAEDTDRVRPAGPVRRPSAPPRTPFVLLIVALLSGALVSLLLLNTVLAQDAFELTRLQRSVKLLDQERQALESDIAREESPERLARKAENLGMEPSAPVAFVDPHTRRVVGGAAQPVPHDAAAAAGAAGALGVPGALIPGDGVIPAATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SQ47</accession>
    <name>A0A1H5SQ47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisH</name>
        <name evidence="11" type="ORF">SAMN04489712_101311</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52564">
        <property type="protein sequence ID" value="SEF52564"/>
        <property type="gene ID" value="SAMN04489712_101311"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF52564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="22298" checksum="61BD83E88BD20ACA" modified="2017-01-18" version="1">MKPKIVVLDYGSGNLRSAERAVARAGAEVTVTSDFDAALAADGLVVPGVGAFAACMEGLRAIRGEQIIGRRLAGGRPVLGICVGMQILFGKGVEHGVATEGCAEWPGTVERLHAPILPHMGWNTVRAPSDSVLFQGLDADTRFYFVHSYGVRRWELPPGRLTPPVVTWAEHGEPFVAAVENTALCATQFHPEKSGDAGAQLLRNWLSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SQM1</accession>
    <name>A0A1H5SQM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52835">
        <property type="protein sequence ID" value="SEF52835"/>
        <property type="gene ID" value="SAMN04489712_101322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF52835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="76" mass="7462" checksum="C00C6341E080AA6D" modified="2017-01-18" version="1">MRFSRSSPGAIGIGAARMTALLRSGSGGVPQGAWAPPEPGDASTEGPDDVRRQAADAAAGLAPAAAPGFVEKASFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T673</accession>
    <name>A0A1H5T673_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein N-acetyltransferase, RimJ/RimL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58323">
        <property type="protein sequence ID" value="SEF58323"/>
        <property type="gene ID" value="SAMN04489712_101500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF58323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="20522" checksum="A6BB3F569E7C2536" modified="2017-01-18" version="1">MFAISLGDGAELRPLEPWRAEEFFAHVERGREYIGRHIGFADAAADLDSARGLLQSYADKTAADTGRLYGIWLDGLLVGGVLFRVFDVGLGNCEVGCWLEPAAAGRGLVTRAARVIIDWAVRERGIHRVEWMVSSDNTPSINVAKRLGMSRDGVLREHYPHRGVRQDIEVWSVLAPEWLSAHGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T9G8</accession>
    <name>A0A1H5T9G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LAO/AO transport system kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59439">
        <property type="protein sequence ID" value="SEF59439"/>
        <property type="gene ID" value="SAMN04489712_101535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="51"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF59439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="35693" checksum="961F94C04FCA99BE" modified="2017-01-18" version="1">MPADLDDYVKGVREGSRAWIARAITLVESTRPDHRELAQRLLTELTPHTGRARRVGITGVPGVGKSTFIDALGTNLTGAGHKVAVLAVDPSSTRTGGSILGDKTRMSRLAVDPDAFIRPSPTAGTLGGVAKATREAMVVMEAAGYDVVLVETVGVGQSETTVAEMVDSFLFLTLARTGDQLQGIKKGVLELADVIAVNKADGPDEMVARKAARELAGALRMLRPASGERGRDIPVLTCSARENTGLDEVWRHIVEHQDRLAGTGELDARRRRQQVGWTWAMVHDRLLAGLHAHPAVRDLAPALERQVAEGTVTPAVAADRILAAFAVPPGDPARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UUP7</accession>
    <name>A0A1H5UUP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme-degrading monooxygenase HmoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78674">
        <property type="protein sequence ID" value="SEF78674"/>
        <property type="gene ID" value="SAMN04489712_10232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF78674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="13111" checksum="2D57E7F6233FD585" modified="2017-01-18" version="1">MKINVLTVSEEMREELERRFGGRAGLVESADGFEHFELLRPVEGTDRYLVYTRWRSDEDFQKWTQSQAFQRGHAEAAQDAARSGHGHGHGHGGPAAMAAELWSFEVAQSAEPKPKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V7W7</accession>
    <name>A0A1H5V7W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin-requiring enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83236">
        <property type="protein sequence ID" value="SEF83236"/>
        <property type="gene ID" value="SAMN04489712_102200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF83236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="70" mass="7579" checksum="807EC2D01F8AFFD4" modified="2017-01-18" version="1">MPEVRAEMVANVWKVVVGEGDQVQDGDTLVILESMKMEIPVLAEDDGVISRLKVAEGDVVQEGDLIAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VC99</accession>
    <name>A0A1H5VC99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84860">
        <property type="protein sequence ID" value="SEF84860"/>
        <property type="gene ID" value="SAMN04489712_102258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="51"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF84860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="27819" checksum="9BF31BBBB2EE4692" modified="2017-01-18" version="1">MTVTREGKITQGIGGRPGRGGDQRLITAFGAELARLVEFIEPELDLEDVVLEVCSGTGRVSRAIARRVRHVTALDRSPEAIREGKREADQDALMNVTFARGDATDLPYADRSFTLLLTRSALHRVEDPAAVLRELVRVSRPGAGLVVADVVRPEGVDGDPDEPAKLRDPAHRELLTAERIAELIGEAGADVRRRDLFDVVRPVDAWLAEVGTPAEAAGEIRARLKAELDGGPATGLRPVLAEDELCVTLATAYLGATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VCI1</accession>
    <name>A0A1H5VCI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PknH-like extracellular domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85062">
        <property type="protein sequence ID" value="SEF85062"/>
        <property type="gene ID" value="SAMN04489712_102265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026954">
        <property type="entry name" value="PknH-like_Extracell"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14032">
        <property type="entry name" value="PknH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PknH_C" evidence="1">
        <location>
            <begin position="30"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF85062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="24188" checksum="120DA4E18FD731EA" modified="2017-01-18" version="1">MWVALAVAVGYLVLSVVSVTGAVRILTRDPTAAELRRAADAEVARRWRAWPAGRIFPERLTYLPGTEEVEYATRAGIAPETDCAGSVDAATATVLQRHGCRAVLRATYADQLEGVVVTVGVVVFPDQQAAYQARQEIPGSPTALRAAAFPGTVAARFDDAARQSGTAERGGPYLVLTTAGQSDGRPATAVAGKQRPDDLFGLVPQLGHTIAQTLSTRALPDCTSADWQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VM58</accession>
    <name>A0A1H5VM58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88392">
        <property type="protein sequence ID" value="SEF88392"/>
        <property type="gene ID" value="SAMN04489712_102377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF88392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="430" mass="45909" checksum="8E7D559E81CBF87F" modified="2017-01-18" version="1">MNSRILINVAVFAALGALLVVWAFSSVVRFDFIDRPYRITAEFESSPGLHPNFEVDYLGTRIGKIDSVRLRPDRVVVRLDIDRGVRIPRGVTAAAARKSAVGEPVVELTPKPGQADGPRMPTDGSAMIPVADTSIPPKYGDLFGAVNKTLEAIDPDSAGTLLHEMAVGWAGRENSLRQIITGTDQLTTTFARDTELIDGLTSDLGRIADVLAANRGQLGAGVDNLAALTAGLRGVRTELAELRDRGPELLETVNGLLADSGPDVECMLGALGGLDLSEHNPGVYEDLRSTLTLAGPMVHVLTNIIGEDQGKKVLNIVFMLTVKKQATLEYKKPLPQPSVAAIPTCADGREPGKSKQKSFPGKDPGDTLPPHDATPQRAPERARTAADSTPDSAGGPPMWLVYVPPLIALLVLIKVMAGSVPVLSRLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WC02</accession>
    <name>A0A1H5WC02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96721">
        <property type="protein sequence ID" value="SEF96721"/>
        <property type="gene ID" value="SAMN04489712_102654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF96721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="21506" checksum="7514DA7A55166867" modified="2017-01-18" version="1">MSPEAPEPGTVRPGGRTARVRTAVLRAAGDTLAERGFAHLDLADVAHRAGVGKTTVYRRWGTVTGLVADLLVDMAEQSLPRTETGSLLGDLKANARLVQRTLSDPRQGALFKAIIAAATCDPRTAEALHRFYDTRIREWAPCVQQAVDRGELPRGTDAHEVVRAVSAPLYYSLLAGGGPLDEAAADRAAQAAAAAARAGVYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WY71</accession>
    <name>A0A1H5WY71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04454">
        <property type="protein sequence ID" value="SEG04454"/>
        <property type="gene ID" value="SAMN04489712_10313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG04454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="365" mass="38987" checksum="74CE0CFA13C1B0B8" modified="2017-01-18" version="1">MPPTPQAASGCLFGLAYGDALGAPTEFLNMRQIRRRFGADGPRDLPGTPALVTDDTQMTIAVAEGLLSALEHPPFTPDLVLPRWRRHFIDWLHDPDNNRAPGNTCLRACRNLDAGTPWVEATQHDSKGCGANMRVAPVGLVPGLSDEQRSGAAQLQAALTHGHPTGLAASELTAFAVWWLREGTAPADLPAALREHCHAQRAVYHERWLEDLWRRPAVPGLSSRRATPGSPESGPGDPRSAGAPLRSPDPQTFIARGWDECLAVLDRLDEALARADRDADPCEITGAGWVAEEALATGLLCFLLFPGDPVAAIRRGAASSGDSDSIACLAGAFAGAHLGMAVWPAEWAGRIEYAGDLARFGRAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WZU8</accession>
    <name>A0A1H5WZU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DO-GTPase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04823">
        <property type="protein sequence ID" value="SEG04823"/>
        <property type="gene ID" value="SAMN04489712_10324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045528">
        <property type="entry name" value="DO-GTPase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19993">
        <property type="entry name" value="DO-GTPase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="DO-GTPase2" evidence="3">
        <location>
            <begin position="258"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG04823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="594" mass="63995" checksum="F6ACAE0C975B2A37" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X0K4</accession>
    <name>A0A1H5X0K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Flp pilus-assembly TadE/G-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05334">
        <property type="protein sequence ID" value="SEG05334"/>
        <property type="gene ID" value="SAMN04489712_10340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="2">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG05334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="40109" checksum="AD8ACC083D00010B" modified="2017-01-18" version="1">MPDLRLLPRGRSRGPRDEGVVSTVFAVLMSSLVVVGMLALVVDVGLLYVEREELQNGADAGVLAAARACAQDEACTPAAFVNAAQTSAEQNARDGAAWAILRCARINGAAAGPCPLDDTQLTRCVGPRPAGGNFVEIRTRTRTADGGTLFPPVFGAAVLGSSYQGGQAAACARAAWGPLGGHSHAFAFGIAECAFEDLTSSPPPAGSGFVPADRIKTVTPDPAQQAQVRQRDCANPADPAPATGPGALAWLGPPGGDCLQDLRADTDVAGIEIPSDWTPPSCQAEGGTVTLETFLADNRRPLPVPVYDSVTPGGGGSHRYHITGFAYFLPTGYWFGPGSAQPSWSDGEDCDGSGATSAGPCLMGFFTKGTVVGAVGTGPDRYGLRAIQLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X474</accession>
    <name>A0A1H5X474_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06619">
        <property type="protein sequence ID" value="SEG06619"/>
        <property type="gene ID" value="SAMN04489712_10383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG06619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="581" mass="60299" checksum="EA8B75FF38126D0C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X6W4</accession>
    <name>A0A1H5X6W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIM zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07127">
        <property type="protein sequence ID" value="SEG07127"/>
        <property type="gene ID" value="SAMN04489712_103102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="405"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG07127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="450" mass="47913" checksum="7040C0900518F465" modified="2017-01-18" version="1">MATAQAYAYTRPSGLAGDQLGLSTSGGTTDSGPKAHPHFFSGLLTQAAPAAAALLGLADVAQARYHQPRPTSMRDPVVTCNGDRLRMESFSACCGVYARLDVLEGALDGEVLERGTTNVDVNGPLREALARVGGSDPLHLAVGADELAVTTLDGAVVEKKVPLPDRWLRGFAEVQVIASGFDLRAELGRAEAVRFLRALPQNPRVEQWAVPAGRTLRLTSRPAPGAVCLAGPHRLATALPLLRFARALRVYGPAVTSGSPPVASAWELELPGMRYVLTLSPEVRRGFSGEGAVLEALATDEAAYDADLVGALLAFEPRVEPDLLAERASLPAGRVRAALTQLGTSGRVGYDAAEAAHFHRELPYDPARVAAMNPRLRSARALADDGAVRFTDPDLAVVTSDGRPRQVRFEGDRVSCTCPWWADHRGGRGPCKHVLAAKLVRQADKEMSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X8E9</accession>
    <name>A0A1H5X8E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotriesterase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08024">
        <property type="protein sequence ID" value="SEG08024"/>
        <property type="gene ID" value="SAMN04489712_103138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289164" evidence="2">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG08024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="34149" checksum="85D7F109C33E3B90" modified="2017-01-18" version="1">MTSRPQLGLLRTVTGSVPASAVTGPVLTHEHLQLDLRWPERRLAAVPSDPRRWLDEEQAVTAELAELHADRELSLVVDLTCQGMGRNAAMLSRISAGGRVAVVAGTGFFAEPFHPHFVADCDEERLTERLMAEIEFGMDGTSSLPGVIGEIGSWGAVPTEAEERCLRAGARAALESGLAVATYGRAGLALLEILASAGLPAERVAVGHQDLVDDPGAHRKIAENGAYVSFGSLGRAGRDAAALGAHVRHVLELLEAGHGERLLLSTGVSRMTHLRRYDGDGYGHLFEVFLPALRAAGVDDGTLWTILHDNPLRWLTGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XBT5</accession>
    <name>A0A1H5XBT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09218">
        <property type="protein sequence ID" value="SEG09218"/>
        <property type="gene ID" value="SAMN04489712_103184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025358">
        <property type="entry name" value="DUF4262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14081">
        <property type="entry name" value="DUF4262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG09218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="177" mass="19975" checksum="20B992F016D171AF" modified="2017-01-18" version="1">MGSACRCIICHDYGDRDRLGNFELRTIVHVKEYGWSVVLIAPRDGRPGWAFTAGLWHTHRVPELAVFGLEPYDMQTIVNNLGDRAAAGLPPAPGQERRDATERHPVALRPVHAQWYDRLLGEALRFYRHPPLPFLQVVWPDADGRYPWQPGSDPALAGSQPCLWLSPDSHPPGVWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YIR7</accession>
    <name>A0A1H5YIR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator PadR-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23958">
        <property type="protein sequence ID" value="SEG23958"/>
        <property type="gene ID" value="SAMN04489712_10437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="118" mass="12860" checksum="03DC091E4A4040A5" modified="2017-01-18" version="1">MVPAMAKRSPLMSEATYHILAALLEGPLHGYGIIKRTQELSGGRVRLAVGTLYGALDRMTGDGLIAVDREETVDGRQRRYFRITDEGHRAVSQEAARMARAAEIVRGRMVARPGTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YS77</accession>
    <name>A0A1H5YS77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TadE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26186">
        <property type="protein sequence ID" value="SEG26186"/>
        <property type="gene ID" value="SAMN04489712_104123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG26186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="15715" checksum="EBD06F237BC8E98A" modified="2017-01-18" version="1">MTVPAICPRRRVRCRDDAGNAVVEAAILAPLFVLFLAALLVAMRIQHGSAVVSQAAADAARHASIARTASQARADATASALATLRDKGLHCTPQVALDLSGFARPVGREGTVAARVRCVVALSDIALPGMPGSRTVTRTHRSPVDPYRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YUV0</accession>
    <name>A0A1H5YUV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27754">
        <property type="protein sequence ID" value="SEG27754"/>
        <property type="gene ID" value="SAMN04489712_104193"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG27754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="20402" checksum="6098A2D17E28FC30" modified="2017-01-18" version="1">MDDKDLGADLANVLIPEDRLQAKIRELAGRIDTDYDGRDLLLVGVLKGAVMVMADLARALHAPVSMDWMAVSSYGSGTRSSGVVRILKDLDADISDRHVLIVEDIIDSGLTLSWLVSNLQSRNPASLEICALLRKPEAAQTEIDVRYVGFDIPNEFVVGYGLDYAEKYRNLPFVGTLAPHVYGGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YVY8</accession>
    <name>A0A1H5YVY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27910">
        <property type="protein sequence ID" value="SEG27910"/>
        <property type="gene ID" value="SAMN04489712_104200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021517">
        <property type="entry name" value="DUF3180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11377">
        <property type="entry name" value="DUF3180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="16668" checksum="56616CC4761489A2" modified="2017-01-18" version="1">MRPTRPALLAALVVGLGLVTWALLQALYESLPKLPWTMVPTLLLLGLGEGFTAYNLWRRIRRRPGTRPVEPLMVARMAVLAKASAHAGAVIAGVFAGFALYLSSQMEKVVPRQDFFVSVGTALAALALVGTAVWLEYACRVPKGPDDRDPGASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z286</accession>
    <name>A0A1H5Z286_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clp amino terminal domain-containing protein, pathogenicity island component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30304">
        <property type="protein sequence ID" value="SEG30304"/>
        <property type="gene ID" value="SAMN04489712_104303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG30304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="154" mass="16056" checksum="860B13F4D2972D0E" modified="2017-01-18" version="1">MAETASRTSLRPVLERAIEEARGRGSATVEAEHLLLALAADGPPAVTVVLAEAGLDYEATEAALREEHVQSLAVAGIGPVDEERLVASPRQSRPGWGASAKAALKNAELGIGRTRGAERNLLIGLLQAELGTVPRALAIAGVDRDALITRLRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z557</accession>
    <name>A0A1H5Z557_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain-containing protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31412">
        <property type="protein sequence ID" value="SEG31412"/>
        <property type="gene ID" value="SAMN04489712_104356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG31412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="85" mass="9785" checksum="3BAA768CA820E338" modified="2017-01-18" version="1">MSRAEAQTFSIDLSERLLTVAEAAEYLNTSERFPRRLIEERRIRFVRLGEPGKRGHIRIPESALREFVNAGLVEPMTVSDNWRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z6Q5</accession>
    <name>A0A1H5Z6Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31325">
        <property type="protein sequence ID" value="SEG31325"/>
        <property type="gene ID" value="SAMN04489712_104352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="186"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="203"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG31325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="447" mass="48596" checksum="27A4A39CC47E2AC3" modified="2017-01-18" version="1">MEVPTAYLVLGALAAAAAGLWAWHRSHPLSFWYGVAFPVRVVRVYLTWRSVASGCKLTRTKRAWRVTLDAIPVVGPAARSAATVVEQKRRVRRVEVDHAPRLGLMKPTPYGWRLRVKLLDGQVPDDYAKVSDRLAHSWRVHGVRVLEDAPGRITLLATRRDPLALVTVTGGAGELLVVRPGVLENGEPWVMDFRTVPHWLIVGATQSGKSNLANAVIRALAPQRVAIIGFDLKGGVEFTPYAPRLSALATTRKESVDLLEKLVAEVEDRMATCRAHGARNIWRLPESARPMPIVVLVDEVAELFLMADKSEKELIAKTGTALLRIAQLGRAFGVFLLVCGQRVGSDLGPGVTALRAQLTGRVCHRVNDPETANMALGDLDPAALEVARSIPADTPGVAVVAGQGGTWHRARAVLVTEEEAEHAARQFADLAPSWDDLVGRHPFLDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z991</accession>
    <name>A0A1H5Z991_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="10" type="ORF">SAMN04489712_104402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32285">
        <property type="protein sequence ID" value="SEG32285"/>
        <property type="gene ID" value="SAMN04489712_104402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG32285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="17510" checksum="F1FFE574912A844D" modified="2017-01-18" version="1">MPRKGPAGKRQLIADPVYNSPLVTALINKVLLDGKRSIAQRIVYEALEGAREKTGNDPVVTLKRALDNVKPTIEVKSRRVGGATYQVPVEVRPARSTTLALRWLVTFSRARREKTMTERLMNELIDASNGLGASVKKREDTHKMAESNKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZHU0</accession>
    <name>A0A1H5ZHU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35305">
        <property type="protein sequence ID" value="SEG35305"/>
        <property type="gene ID" value="SAMN04489712_104540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG35305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="377" mass="40946" checksum="0C66009CC73F7529" modified="2017-01-18" version="1">MVRVIGGIWQRVTSGWDLVVEALHGARRRSAWFDHLARAFERYDDKRGDRLAAAITFYAFLSFFPLVALGYSLLGYLVGISEEARRYMVQAFTELLPGLNGELRVEQIAEARSAAGVIGLAGLLFTGLGCMNAVREALRDIWLGDPTGGGNFFLKKLYDIGTLAFLGSMLILSVVVSTVTGQASHTVLDWVGLGDTPGAGTALRLLSLAVATGFNTLIFLMLFSRVSGTRAPWRDVLRGALFGAVGFEILKLAGTLVVTHIARNPVYVSFAVVAGLLVWIDVVARFLIFSAAWTATRRVVLRADAANEANKVDSGPCDDRTPRNGRTDHEPDREPHPEADRASDREPVREADQAPDRGSGREPGQARAAKPTPVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZU16</accession>
    <name>A0A1H5ZU16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR HTH family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40023">
        <property type="protein sequence ID" value="SEG40023"/>
        <property type="gene ID" value="SAMN04489712_10511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG40023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="29939" checksum="5F4BE7C537A38D6E" modified="2017-01-18" version="1">MNEDGTQEAGYGIGAVARRLGVPAATLRTWNLRYGIGPSRRSPGGHRRYGTADLRRLETMSRLVREGMPPAEAARKALRLPGGPPAAPDGVPSAPALVEAALALDSRAVADGLAAALAGHGATWTWQRLVRPVFAAIVDRQAETGGCVDVEHLFSERLLAALLPLGEPPGSPAGRLRPVLLACAEDEQHSLPVHVLAAVLAGEHGVGVRVLGARTPYSALAASMSALDPAVVFVWAQRSVTGDPAPLAALPGPPERIVVGGPGWTAAPPAGIAQVTSLDEAVSRVLAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZXD8</accession>
    <name>A0A1H5ZXD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40634">
        <property type="protein sequence ID" value="SEG40634"/>
        <property type="gene ID" value="SAMN04489712_10543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG40634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="26088" checksum="BC92361DB5471506" modified="2017-01-18" version="1">MSTPDDDFLVVEDLHAGYGGARVLHGVSLTVGRGEVCAILGPNGAGKTTLLRALCGMVKGRGAVRLGGTGLLGRPPDAVARLGVAHVPEGRGTFLPLTVEENLRLGAFTRRDRAAVQADLERVHGYFPVLRKRLKQQAGSLSGGEQQMLALGRALMLRPRLLLLDEPSLGLAPMVTRELFGIVRSINEEERTTVVVVEQNAHLALGIARQAHVLETGRIVLSGPAERIRADEQVARSYLGYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZ25</accession>
    <name>A0A1H5ZZ25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PD-(D/E)XK nuclease superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41719">
        <property type="protein sequence ID" value="SEG41719"/>
        <property type="gene ID" value="SAMN04489712_10595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="18"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG41719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="33417" checksum="57665B57B5FFB013" modified="2017-01-18" version="1">MAEQLGFEGMPQRLYPCTPSRLNTWLDCPRRYRMTYLDRPAPPKGPPWAHNSLGISVHNALAAWWRLPLPERTAEMAGTLLLRGWLTEGYRDAEQSAAWRERARAMVERYVSRLDPADEPLGVERTVAAKTARIAMQGRIDRLDARGGELVVVDYKTGRREPTADDARSSLALALYAVAASRVLRRPCRTVELHHLPTGTVAAWEHTDDSLDRHVRRAEQIAAEASAADEAYRGDLAPAASKRRLAGEEGIDHSPFDEVFPPRPGNLCAWCDFNRHCPEGRQAAAPKEPWAAVTAAEEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A5L4</accession>
    <name>A0A1H6A5L4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43721">
        <property type="protein sequence ID" value="SEG43721"/>
        <property type="gene ID" value="SAMN04489712_105213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="59"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG43721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="813" mass="86976" checksum="7E0F26E59BBA2CD5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AHG4</accession>
    <name>A0A1H6AHG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein-S-isoprenylcysteine O-methyltransferase Ste14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47951">
        <property type="protein sequence ID" value="SEG47951"/>
        <property type="gene ID" value="SAMN04489712_105449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG47951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="227" mass="23970" checksum="B4EB0E4E5E3087BD" modified="2017-01-18" version="1">MATAALIIYLVWAALAFGLRSWVQWRRTGDAGFRGSGLRPGSMQWWVRLLFTSAMVIGAAGPIAALAGLAPIDVLDRPVVQVAGAVLALGGVAATLAAQTSMGASWRIGVDEAERTALVTTGAFALARNPIFTAMMATATGLTAMVPNPVSLFGLLLTVLAIQLQVRVVEEPYLQRVHGDAYARYAAAVGRFLPGLGHLRSPLRHRPHHTPAPADEPPSVSDMSADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJJ3</accession>
    <name>A0A1H6AJJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48237">
        <property type="protein sequence ID" value="SEG48237"/>
        <property type="gene ID" value="SAMN04489712_105464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG48237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="292" mass="30442" checksum="01B16FC946000058" modified="2017-01-18" version="1">MFDFLGYYNAILIHQSLIIGLLVISVLIAMQAGLLNLAPVGFMAFGAYTSALLTVEAGVSMTVGALAGALTTGLLALLFAVPVLRLRGIYFAMGSLALGQAIVVIIGAVEFTGGQLGLNAIPMGVPTVLLVVLVVVACAALEMVRRSYVGRGLAAIRLDERTAQGLGVSAYRYRLVAFVISGALAGLSGALDVHSNGTVAPSQFDFGLLVVILTYVLVGGVGHWVGPVLVTAAVIVLREWVGLLGTEVEDIVYGLLLVVTMVLAPQGLSDPAMWRRLKSKLQAKREAKVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AMP4</accession>
    <name>A0A1H6AMP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crotonobetaine/carnitine-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49444">
        <property type="protein sequence ID" value="SEG49444"/>
        <property type="gene ID" value="SAMN04489712_105532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030310">
        <property type="entry name" value="FadD17/FadD6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="PTHR43107:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="33"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="420"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG49444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="533" mass="57357" checksum="12C04D2C3933AE8A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AUK5</accession>
    <name>A0A1H6AUK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ORF">SAMN04489712_1064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52072">
        <property type="protein sequence ID" value="SEG52072"/>
        <property type="gene ID" value="SAMN04489712_1064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG52072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="23188" checksum="45B60AFDA8FFE610" modified="2017-01-18" version="1">MSMPPTFPEPQPAVARVAEAQLLPLGDQLFQQLLRKRIVFLGQQVDDDIANRICAELLLLSAEDGQRDIYLYINSPGGSVSAGMAIYDIMQYVPNDVATVGMGLAASMGQFLLCAGAPGKRYALPHARIMMHQPSGGIGGTASDIKIQAEQMLYVKRTLAERIAMHTAQPLDQIERDSDRDRWFTAEEAKDYGFVDHVVRSANQVPSEGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWA4</accession>
    <name>A0A1H6AWA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52357">
        <property type="protein sequence ID" value="SEG52357"/>
        <property type="gene ID" value="SAMN04489712_10625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="24345" checksum="D02C9B15ED8E6926" modified="2017-01-18" version="1">MRLVSHNISYSTADKANVLAFLGSAGDLTAKQQRRLGMMREAARARQDDLDNQGVDWGLSIPDALEHLIAGRLDSDAQYAGNAYHAALQHIIDYNGSDPDHLCTMSNPALFYGLVDKQMRPLGVPADLLPYGFLYGGPPAEFPFLPGSIDGYPAIGHLPLAKAKPAADAYRAVLDQMDADFRYDVQVLIDKLEFEHGEWEQATKRLDWYTQDTIFFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AY63</accession>
    <name>A0A1H6AY63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52736">
        <property type="protein sequence ID" value="SEG52736"/>
        <property type="gene ID" value="SAMN04489712_10651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="18001" checksum="9DCE8AA197091244" modified="2017-01-18" version="1">MGRVRFVRFTDDQGEPLIDPRAYLERLPELAPELPPGAREFATDPGHYDFHGQRCVKDLKLRSQAWDPEANALELFFRHNCWKHEEDLTIRYAGLRSLHTDLAVVSDPVSTTFDVVLDEVLPHQGGCLHEIEFWGGTMVVAADDLTAAWTGADCPDRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5Y5</accession>
    <name>A0A1H6B5Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56239">
        <property type="protein sequence ID" value="SEG56239"/>
        <property type="gene ID" value="SAMN04489712_106297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="162" mass="17928" checksum="A3737764778ED288" modified="2017-01-18" version="1">MSFLGGIGAVVLARFTDVISGGTGWLALQVGIIATLVFSFVGFTLFGREAKNVQAQFDRRFAEQGIRGAARVVNYRDPGPGARKKNLIMHMELELELPDRIDPARWYWGVVPSTDIARLTTAERLPCLVLWDGQALVRLYARQDIAAPHLDGEYIDLAPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6L9</accession>
    <name>A0A1H6B6L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PQQ-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56055">
        <property type="protein sequence ID" value="SEG56055"/>
        <property type="gene ID" value="SAMN04489712_106280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="523" mass="55563" checksum="4B87B1E8D756187E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BE94</accession>
    <name>A0A1H6BE94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59121">
        <property type="protein sequence ID" value="SEG59121"/>
        <property type="gene ID" value="SAMN04489712_10748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG59121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="371" mass="38278" checksum="489263B3BAFA5505" modified="2017-01-18" version="1">MSSALSRALRPTVIAAVAGLVVMLVIPFYAEPFLLQAGLFAMAAAIGAIGLNLLTGSTGQLSMGHAFFLAVGAYGYVYFAGDSGHELSGLGLPTPLAAVLAVVLAGLAGGLFSPIAGRLRGTYLGIASLALIFIGQHILHNAHAITGGANGRDVPPLELAGFSFADTPELVVFQVPLRALEKLWFLALLLLLAAAWVARGILRGRPGRAMGTIRDHEIAAGVMGVPVARYRAGVFVLSSMYAGLAGVLLAMAFRRTVPDYFGIILSLEYLAMIVIGGLGSVAGAVAGAAFVSLLPPLFTRYGDGLPLIAAPGAEGVSPAEASRILYGAAVVAVVLFFPGGLLGVWGRVRASLAARRTSHPLTRMEPEEQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPM9</accession>
    <name>A0A1H6BPM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62347">
        <property type="protein sequence ID" value="SEG62347"/>
        <property type="gene ID" value="SAMN04489712_107290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG62347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="24155" checksum="9C7CDBDEE6155471" modified="2017-01-18" version="1">MDDIAGARVAVVTGAASGIGAATVTELSQRGWTTVGLDLRPSTGAHHAVTLDVSDPAQVRAAICRIERELGPVEAAVCAAGHYAIVPLADIGWTEWLRMLRVHLGGLLNVCRAVVPGMVARGHGTIIGFTSDLAVGGSDGDVHYSAAKGTVIGLVRALAAELAPSGVRVNAIAPGPTDTPLLAPDSPWRRPSYVRMLPAGRLVSPEEVALSVAYLVEEGTFCVGEVLSPNSGSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZE3</accession>
    <name>A0A1H6BZE3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_108137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65805">
        <property type="protein sequence ID" value="SEG65805"/>
        <property type="gene ID" value="SAMN04489712_108137"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="13"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG65805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="329" mass="35593" checksum="5B254E17DBF084B8" modified="2017-01-18" version="1">MISGERRIRRAVVTGGAGFLGSHLCERLLHEGVSVICMDNFLTGTPRNVAHLMGRTGFRVVECDLTGFVHVPGDVDLVLHFASAASPIDYLKLPVETLKVGGLGTLHALGLAREKGARFVLASTSEVYGDPLRHPQREDYWGNVNPVGPRSVYDEAKRYAEALTTAYRNSRDVDTGIVRIFNTYGPRMRPHDGRAIPTFIRQALAGEPLTVAGDGSQTRSICYVDDTVAGVLALARSDLAGPVNIGNAEETSVLELAETIRDLTGSHSPIEFVERPIDDPSVRCPDTTLAAERLGWRPRVPNTEGLRRTIDWFAAELGLTGGRRAAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2C3</accession>
    <name>A0A1H6C2C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Creatinine amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_108259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67160">
        <property type="protein sequence ID" value="SEG67160"/>
        <property type="gene ID" value="SAMN04489712_108259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023871">
        <property type="entry name" value="MftE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03964">
        <property type="entry name" value="mycofact_creat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG67160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="23678" checksum="9EFF9173AB9E133A" modified="2017-01-18" version="1">MTRPLADATWPQVEARPRQVLLVPVGSLEQHGPHLPLDTDTRIAAAVAHHAHESRPQTGLAPAIAYGASGEHAGFPGTVSIGTRALALLVVELVRDASRDWAGILVVNGHGGNADALRQAAQVCAQEGRRLVVHHLHTPGGDAHAGRTETSLMLHLAPSAVRHDLAEAGATDPLPALMPRLRAEGVRAVSPNGVLGDPAGATATEGARLFQGLTRSLLDRIDDEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C430</accession>
    <name>A0A1H6C430_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_108282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67385">
        <property type="protein sequence ID" value="SEG67385"/>
        <property type="gene ID" value="SAMN04489712_108282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG67385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="33212" checksum="C40979575CE4F779" modified="2017-01-18" version="1">MTRPSPDPDQQVFNRHRNLLFSVAYRVLGTAADAEDAVQDAWIKWSAADRSQVADPKAYLTRIVSNLALARLRSTRYKRETYVGPWLPEPILTSGDTAEAVVDAESVSMAMLVVLETLSPLERAVFVLKEVFGFGHAEIAEAVERSEAAVRQAAHRAREHVRARRPRFTVDRSRQREVTERFFAAAAGGDVNALMELLSPDVTLWTDGGGKVRQALRPVVGAPTVAAWFAAIGTVAYQGVEPADMNAELVEINGGPGLVFSGPGRVIATVTFDFDADGRITAVHNVANPDKLRAVAEGTAHDVGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C774</accession>
    <name>A0A1H6C774_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68758">
        <property type="protein sequence ID" value="SEG68758"/>
        <property type="gene ID" value="SAMN04489712_10917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG68758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="23811" checksum="44706C15C9FCC44D" modified="2017-01-18" version="1">MGGDRRETLDGIRAKLELLRRVEAEHGFGVIIEGPRELERVPELPEGVTEVFGLFSRLGGDYFRFAQPEETAGPRAWAERHVDPYCPLGNPLGIGCERFGAPEDIECGSGIYLDLKDGDVYFCDGDDYVFAYENPVDIVETTELAPDIVTFFDFHVLGAGYPQLIESVIDRHGIPNRVPRSRRAHHDRRGRHRDGWMRLLLESGLVSSADVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C797</accession>
    <name>A0A1H6C797_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA ligase, Rnl2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68607">
        <property type="protein sequence ID" value="SEG68607"/>
        <property type="gene ID" value="SAMN04489712_1096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_ligase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="34179" checksum="5F538045DB83FBB0" modified="2017-01-18" version="1">MRYPKIPQRFGDGPLPRGAWVAEEKVHGANLALVTDGVRARAASRRGLLDTDELDAFFGLARIWPVLATSAVAVARELVRERPDVTEVVLFGELAGGRYPHPHVPEVAGLAPVQTGVWYSPDLVWLGFDAVARTASGPLWLGRAELEERLSRTGLGCVPLLGRGRRNELRELPVEFPTRVPAGLGLPELPDNRAEGYVLKPAGSWPSWEKGERPTLKVKHPAFAEDDRYNGSRPFIPPPEGAAGVPAWLLAAAVDRLTPARVASGRSKLGPAAKPDALAAEVLDDLLTDLAEDVGGLSAPDRASLAAALTPGVRTLVTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8H9</accession>
    <name>A0A1H6C8H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69280">
        <property type="protein sequence ID" value="SEG69280"/>
        <property type="gene ID" value="SAMN04489712_10968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294559" evidence="7">
        <location>
            <begin position="19"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="795"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="735"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG69280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="832" mass="85570" checksum="D9C46A6D22E6FB60" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAY3</accession>
    <name>A0A1H6CAY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70013">
        <property type="protein sequence ID" value="SEG70013"/>
        <property type="gene ID" value="SAMN04489712_109134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="30303" checksum="2A0D468DDEAA95BB" modified="2017-01-18" version="1">MEGIGEPSAGAGRVPVGIDPTVPSIARVYDYMIGGKDNFASDRAVGDMIKEQLPGAVTIAVENRRVLGRAVRYLVRQAGIRQFIDIGSGLPTAENVHQVAQRHAPESRVVYVDSDPIVLAHGRALLDENDRTAVIQADARDPRGILDDSATRKLIDFDRPVGVILCAVLHHLEDEEDPAGIVATLREAVPSGSHLFITHFRTEHNEESQQIEQMLQASFGRGRWREQHEIESFFTGLEMVDPGIVPLVEWHPDTPPDREPTAWDRLIVGGIGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CB16</accession>
    <name>A0A1H6CB16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_109147</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70170">
        <property type="protein sequence ID" value="SEG70170"/>
        <property type="gene ID" value="SAMN04489712_109147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG70170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="563" mass="59371" checksum="1B0FE547295BFCB9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CE38</accession>
    <name>A0A1H6CE38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_109247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71168">
        <property type="protein sequence ID" value="SEG71168"/>
        <property type="gene ID" value="SAMN04489712_109247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG71168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="25938" checksum="8E3355E1C6EB2214" modified="2017-01-18" version="1">MNALEAGAVFAAGVGAGGINAAVGSGTLITFPTLVALGFPPVVANISNNIGLVPGSVAGAYGYRAELNGQRERLLRLVTASLAGALIGAGLLLGLPAEAFRVIVPVLITAALVLVVVQPRLNAWLSARREHHHPHGGPWLWAGVLAAGIYGGYFGAAQGIILIALLGIFLDDGLQRANAAKNVLSAVVNGVAALLFTVMWALGRAEIDWMVVLLIALGATVGGLLGARVGRRLPPAVLRGVIVAVGLTAIVNLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CED5</accession>
    <name>A0A1H6CED5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71380">
        <property type="protein sequence ID" value="SEG71380"/>
        <property type="gene ID" value="SAMN04489712_109265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG71380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="16266" checksum="F0F3A8D326C3B403" modified="2017-01-18" version="1">MATVEVSFSALPVHVRTARLIVTAVARRSGVTETLLDEVRLAVGEACSRAVEAHRRHCPDEPVRLELTADGRRFEAVVSDSVPGDDAAGTAAIDPAPAVPSLPAGEPQYSEDAFGLGLADDTAELGLAVIAGLADDVEIETTPKGVQIRMSWPIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIA7</accession>
    <name>A0A1H6CIA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Effector-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72694">
        <property type="protein sequence ID" value="SEG72694"/>
        <property type="gene ID" value="SAMN04489712_11027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG72694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="18747" checksum="C95BF038192B55C6" modified="2017-01-18" version="1">MRSEPRIEERAARPYAAIPIKAPMREWDRVNALVPEVFGWLARQGIAPAGPLFYRYWVIGDRDAPFEVEVGVPVAEAVEEDGRVIAGSIPAGRYATLTHHGHPDGLFGSITALRRWADDHGIAWDIRQEGDSEVWGGCFEFYPNDPAVEPDMDQWSIELAYRVRDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIP2</accession>
    <name>A0A1H6CIP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane associated serine protease, rhomboid family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72788">
        <property type="protein sequence ID" value="SEG72788"/>
        <property type="gene ID" value="SAMN04489712_11035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="60"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG72788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="202" mass="21565" checksum="BA84DC3CB6B97EB2" modified="2017-01-18" version="1">MSNPVVPRRSRSEGLMTHATRAVSAAVLVVAVTAGMWALEIYDYAAGNRLDAYGIRAHDAGELPQILTAPFLHGGFEHLMANTMPFLVLGFLAAARGIGRFLAAALIIIVVGGLGVWFTGSPTVETLGSSILIFGFFGYLLGRGLFERNLLDLVIAVGVAVFYGTMIYGVLPTDPMISWQGHLFGLIGGVLAAFTLRRRIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLV8</accession>
    <name>A0A1H6CLV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_110171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73932">
        <property type="protein sequence ID" value="SEG73932"/>
        <property type="gene ID" value="SAMN04489712_110171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG73932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="25227" checksum="788FBCEE8424D0E8" modified="2017-01-18" version="1">MTATAAVDLPSVMQTVLLVMAAFGAAVLSAVTGFGGGVLLLAVCIAVLGPRNAVVVVTIAQLASNGGRAWFNRAEIDYRLAGVFCIGAVPGAVGGALLLISTPVDILARIIGGFLLAMVLWRHLSPATARVPVPVFVGVGAVAGVGSGLLGSLGPLVAQLFLARGLVRGAYIGTDAAATLIMHVTKLVVYAVTAVLNATNLLVGLVLAPSSIAGSWAGKQIVDRISATVFVLIVELALVTFGIALLIGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM05</accession>
    <name>A0A1H6CM05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NitT/TauT family transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74001">
        <property type="protein sequence ID" value="SEG74001"/>
        <property type="gene ID" value="SAMN04489712_110179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294989" evidence="1">
        <location>
            <begin position="28"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="338" mass="35179" checksum="EB607741D1CC7492" modified="2017-01-18" version="1">MPKKTLAAGIALALTAAGCANSGGGAADSLKIGYFQGAVAGPEAVVAANDDLASAIPGRIELRPIDSGVAGMAQLRAGAFPVVSGVGNPPFVGAFTSGTDVRVVFAESLDQSGLAVHDNIKSPADLTKVGVLVGSTLDFQLRGWLKEQNLTGKVEIASFASEAAEAAAWKAGKIDAVFISQAFLLELKRHGARVLVSSTEIAEKGYAAVNLLAVTSSYIRQKPEVVQQLVCQISKAQTLVKGPDGEKYIRPAARFLGVKPEDSVEATKGYPYIPAAEETSWLKGPDGTAASGRLVKNFRLTAEFLVAQGRAESVPSTEQIAEHVDPTFWDKAQAGGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CPE4</accession>
    <name>A0A1H6CPE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, LacI/PurR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_110210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74296">
        <property type="protein sequence ID" value="SEG74296"/>
        <property type="gene ID" value="SAMN04489712_110210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295095" evidence="4">
        <location>
            <begin position="18"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG74296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="373" mass="39070" checksum="15FEA8E51F4075EE" modified="2017-01-18" version="1">MVGFLSYLILGLSVSCAIGSYTCAMGQPAGESAKTRRLAEVAKKVGVSEATVSRVLNGRPGVSDATRAAVLTALDVLGYERPTQLRGERARLVGLVLPELGNPIFPALAEVIGGALAQRGFTPVLCTRTAGGLSEADYVNMLVDQHVSGMVFAGGHYAEMDSPHEHYFRLMELGLPVVLVNAAVPELAFPRVSTDDAVAVEQAFTHLASLGHERIALMLGPEDHIPSQRKLAAFRAVAAGRGTPVAEDAVVHAMFSIEGGHSAASRIITAGFTAVICASDVLALGAIRAVRRAGLSAPEDLSVVGFDDSAFINCTHPPLTTIRQPIEAMGRAAVTMLVNQMERGSVPAEELLYEPELVVRGSTAPARVAVTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSW9</accession>
    <name>A0A1H6CSW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76120">
        <property type="protein sequence ID" value="SEG76120"/>
        <property type="gene ID" value="SAMN04489712_111125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295168" evidence="2">
        <location>
            <begin position="17"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="20804" checksum="033B8DA8D194E7F9" modified="2017-01-18" version="1">MGLMSVVRWVRAVSFAATCAVLATLGHLTGGGSLDRSAVLTGFLVIVVPALALTGRERTLASILPATAVSQVVLHVLLTKAQGAAPAPAAPAAPMGGAAGMEAMEHGTPGLGMLLMHAVSVLVTSAWLEWGEARLCALVRQLTGWVLRPLLFLLYLAAGSASTWPRPIVGARTGECAPVQAVLRYAVVRRGPPGTWCVPGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT65</accession>
    <name>A0A1H6CT65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75863">
        <property type="protein sequence ID" value="SEG75863"/>
        <property type="gene ID" value="SAMN04489712_11192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021219">
        <property type="entry name" value="DUF2703"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10865">
        <property type="entry name" value="DUF2703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="183" mass="19490" checksum="AD5280757DA5F819" modified="2017-01-18" version="1">MTTAQAHDVLSPVLPPTLRDAPPRVRLSVEYWTVTMDGADSCGSCDETLTALQTALAQVRPVAQALGIDVDIVPRTVATWAQALEHVIVASPTIRAEGIELHPMHSGDTEARVWWWRGAISDTVPGQALTDLLVRALAARSRRLGVYLEQGGPAPYVRRYLQVDPAAVMPVASGSGCGPSACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTE3</accession>
    <name>A0A1H6CTE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76128">
        <property type="protein sequence ID" value="SEG76128"/>
        <property type="gene ID" value="SAMN04489712_111126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08026">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044543">
        <property type="entry name" value="YHJQ-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="16906" checksum="4FE08CEF6E08DD74" modified="2017-01-18" version="1">MASTTMQMLETYPAEIELDRRMLAEVIDALKDCAQTCTACADACLSEPVEELQNLTRCIRDNLDCAEICTTTASVLSRHTGYDANLTHAQVQSAIQATKTCGDSCDEHRDTHEHCRICAETCRSTEQALNGLLPHLEPSGKGAQRPGRAAPQQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYV6</accession>
    <name>A0A1H6CYV6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="9" type="ORF">SAMN04489712_11254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78261">
        <property type="protein sequence ID" value="SEG78261"/>
        <property type="gene ID" value="SAMN04489712_11254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="598"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG78261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="637" mass="68046" checksum="9EBFD759A0AF26B1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2H0</accession>
    <name>A0A1H6D2H0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_112236</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79559">
        <property type="protein sequence ID" value="SEG79559"/>
        <property type="gene ID" value="SAMN04489712_112236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="28"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG79559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="31442" checksum="A14F4C7E66B2942D" modified="2017-01-18" version="1">MTQAAPLPPLLEPDASGGLREVFRRRYLLRLLVRRELRARYKSSMLGLGWSYVRPAVYFCVYFFIVGYVLGAGRKLEDFAVYLFSGMVLVNLFNEILHSATRSVTGHAALVRKIFLPREMFPVASVLVSLVHFVPGLVILMVAAVPAGWRPDPAALAGAVAGFAIVVLLGLGAGLLLAAGNVFLRDLEQAVDVTSAVIMWSAPVIYPWTFMRDGAPGWVLDLYLINPLVTAVSLFQRAFWQPGVEDAYTFPPDLALRTVGSLAFAVMVLAIGQQVFAAAQRRFGQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4H9</accession>
    <name>A0A1H6D4H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80259">
        <property type="protein sequence ID" value="SEG80259"/>
        <property type="gene ID" value="SAMN04489712_11351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG80259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="37507" checksum="EC109551D007AA1C" modified="2017-01-18" version="1">MSTPSGGGAKVPLPRAGTVGIKHVAQHAGVSPGTVSNVLNRPERVAPATRARVERAIRELGFVRNGSASTLRAGQSSSIGLMILDLGNPFFTDVARGVEDVASERGYAVILASSGGSHDKERRNLTVLAEQRVRGVLITPVDQEGDQAELLRRRGVAVVLLDHPTPRANQCSVAVDDVAGGELAVGHLLEQGARDVAMVTGPSVLRQCADRRKGALRALRAAGLGRDALREVAVPAMNARAGQEAAQRLLEGDLPDAIFCANDLLALGVLRVLLQAGVKVPGDVALIGYDDIEFTAAAAVPLSSVRQPTYQLGRIATDLLLDECDNPSGHAHQQVMFQPELVVRESSRQLIAQPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5Z6</accession>
    <name>A0A1H6D5Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80750">
        <property type="protein sequence ID" value="SEG80750"/>
        <property type="gene ID" value="SAMN04489712_113145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="55" mass="5941" checksum="590F93917EAE3047" modified="2017-01-18" version="1">MPVRPLTSRDPVQISGYRLPGRLGEGGQGVVYLAEYGSDEQEPGEQSPEAQERPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7E3</accession>
    <name>A0A1H6D7E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81240">
        <property type="protein sequence ID" value="SEG81240"/>
        <property type="gene ID" value="SAMN04489712_1145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="30123" checksum="2AE8FE511A351E3E" modified="2017-01-18" version="1">MAILVTGATGRVGSRFVPRLLRGGEPVRVLARDPRRAELLGRLGAEVVIGDLRAAGTLADALEGVDAVVHLGAAFRDVPDKEAVAVNHTATVELAEASLRAGVSRFVHVGTTLVYGNGRGRPARESDEPAPPGWAYTTSKVAAEKTLLRLHEAQGLPLCIVRLAFVYGEGDPHLAESLHWAGDWPPHKRLHLVHHADVGQALLRVLRADGVDGEIYNVADDAPVTYLELQNLNGEPGTAGTAGDRSFDDPWEGIVDTSKIRHELGFRPIYPTVYTAEAAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7Q4</accession>
    <name>A0A1H6D7Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81321">
        <property type="protein sequence ID" value="SEG81321"/>
        <property type="gene ID" value="SAMN04489712_11425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG81321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="31245" checksum="12C4AD003A27C76C" modified="2017-01-18" version="1">MTRGKAGDPDHGVELLWERDGRESRRGLSLEEIVRTAIEVADAEGLAGLSMRKVAERLGFTTMSLYRHVPGRDHLIDLMSDAVTGPPPAPPAGDGWRPRLEACARHAWHLRERHPWLAEVRGTRHIPGPNTVAHYERMLSTLAGTGLSPAEVIAAVEVVGRFIDAQALTLVEIAQAERGSGVSEQEWWGARDSLYAHLDRYPTISALWEAGGYDRPEDPFEFGLARLLDGIEALVTQRRDEIRDENCRVCGEPVEQPSAGRPRRYCSRACQQRAYRARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D853</accession>
    <name>A0A1H6D853_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein Atu4866</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81268">
        <property type="protein sequence ID" value="SEG81268"/>
        <property type="gene ID" value="SAMN04489712_11412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038646">
        <property type="entry name" value="Atu4866-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020955">
        <property type="entry name" value="Uncharacterised_Atu4866"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11512">
        <property type="entry name" value="Atu4866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="89" mass="9780" checksum="BAF1DE42D0CF643C" modified="2017-01-18" version="1">MAKDSAHGPDIGVVGMWVTADGYIRQELRADGRYDEARGSRASAYTGRYTVTGSHIEYVDDTGFTATGDVRGGVLYHEHLVLYRERPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D925</accession>
    <name>A0A1H6D925_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Selenocysteine lyase/Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81353">
        <property type="protein sequence ID" value="SEG81353"/>
        <property type="gene ID" value="SAMN04489712_11433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="28"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG81353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="404" mass="41983" checksum="1B05BCEDEBE35BAA" modified="2017-01-18" version="1">MSVLTRVPQVVGAGLPVPVPGGSVPYANLDHAASAPCLEAVQEAVVRALPAYSSVHRGAGYASQVTTRAYETARETVRDFLGGPEAVVFTRNTTDALNLLAGAVPEGTSVVVFESEHHATLLPWRNAVRLPVPASPGAALADAEQALRQCPAGPRLLVVTAASNVTGELWPIAELAEIAHRHGARIAVDAAQLVPHRPLDARGLDYVAFSGHKLYAPFGAGVLAGRADWLRAADPYLRGGGASSHVGDGVRWAADPEQRHEAGTPNVLGAVALAAACATLAAGWDTVAEHERRLLERLQAGLADLPGVRELSLWGLEHPRVGIVAFTVDGHAPRAVAERLSAEHGIGVRDGRFCAHPLVRHLVGGAAGEGCAEGDTAIRASIGLGTVDEHVDRLLEALAAICDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBH9</accession>
    <name>A0A1H6DBH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82638">
        <property type="protein sequence ID" value="SEG82638"/>
        <property type="gene ID" value="SAMN04489712_11554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="15843" checksum="1BB769D1D3EC0B67" modified="2017-01-18" version="1">MKVKESGVLIGELSRRTGVHPHQLRYYEAQGLLEPGRGANGYREYADDAVLTVAQIRKLLKAGLSTEEIGYMLPCATGSGPDLEPCPELLDTLRTRLHRMDEHIDTLVHSRQALHDYIEATEQRVSQHHRRCDSTAPASAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBS0</accession>
    <name>A0A1H6DBS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82273">
        <property type="protein sequence ID" value="SEG82273"/>
        <property type="gene ID" value="SAMN04489712_1152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="34758" checksum="A2F0FB0A64D7A041" modified="2017-01-18" version="1">MRALVAKQYGPPEGLTVEDVPVPRPGPGQIQVRIRAAAVNPADLRTLSGVLRELTPLTFPHVPGSDFAGTVTEVGPDVTRFTWGDEVFGVGLPRATATIAGMLSTPPSLTTGAMADYAVFEADTPAITRRPDGLAADHAASLPISGLTALAVVRAGRFEAGERVLVTGAAGGVGGAVVPLLAAAKVHVIATAIPEDDDYVRDLGATEVIDYRTVDTVAETLRRHPGGVDAMVNLALPGPALVKASDAIRPGGHLLNVAFPSPEPSAFDHADLTVRTVYSTARPGDLEELAAQAMAGSLPATISRRYSLEEAARAYADLVHTHVRGKLLVIANATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFM6</accession>
    <name>A0A1H6DFM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83882">
        <property type="protein sequence ID" value="SEG83882"/>
        <property type="gene ID" value="SAMN04489712_11691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="41372" checksum="1C2DEF5F302F3C26" modified="2017-01-18" version="1">MGTDLLERRAVISGVGQSAIGRRVERSGLQLTLDAVLAAVEDAGLTLDDIDGLAMFPGGGAANLPGYANGNLYEVQDALRITTTWRQGIIEGMALPFYGPAMAVATGQARHVVVWRTVKEGSAARAAGGRPAYGAGKPVAEGPLAWLLPIGMLSPVCQVAPYAARYMHEYGVTREQLAWIPVTQRAHAALNPDAVYRSALTVDDYLAARMISTPMCLYDCDVPADGATAIVVSAAGTAPALRAPVRIEAMAGVVEGRPSWEQWEDMGRVGHGAARAMWARTGLRPGDVDVAQLYDGFTIEAVWWLEAMGFCGTGEAGAFVEGGERIALDGELPLNTWGGQLSGGRLHAAFGHTAEAVRQLRGEAGARQVRGAEVAAVTNVGGLEAGAALLTRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHV5</accession>
    <name>A0A1H6DHV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84810">
        <property type="protein sequence ID" value="SEG84810"/>
        <property type="gene ID" value="SAMN04489712_11772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="45"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="252"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="36359" checksum="CE84C651DFDA1BBE" modified="2017-01-18" version="1">MTVAAHDIDQAAALLQRTVAEIKKVIVGQEHMVERMIVALLAKGHCLLEGVPGVAKTLAVGTLAQVVGGTFARLQFTPDLVPSDIVGTRIYHPSTEQFDVELGPVFVNFVLADEINRAPAKVQSALLEVMAERQVSLAGKTFPLPKPFLVIATQNPIESEGVYPLPEAQRDRFLMKVNVRYPGAHDELQILQRMSVDPPAATQILDPAQLTALQHAAAQVSVHELVADYIVRLVMATREPAHYRLPDLRPVIDIGASPRATLGLVAAARALALLHGRDFVLPDDVRAVAPDIMAHRIVLTFDALADGIDTGEVIDQILAAVPPPRVVWNHDQAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DK55</accession>
    <name>A0A1H6DK55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_117122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85046">
        <property type="protein sequence ID" value="SEG85046"/>
        <property type="gene ID" value="SAMN04489712_117122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="401"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="487" mass="52236" checksum="3FC3B99C76853E0F" modified="2017-01-18" version="1">MRENSILMNIVTILEKAAAAGDRVAVTAGDRSPTASELLRLAHAAARRFRDFPAVLYLGANHLAYPVALFGAALAGVPFVPLNYRLGDHQLTALRERHPGALVLRPADLDGFIETAEREAGAQKAEPAPGGDEDSVAVLLYTSGTTAAPKAAVLRHRHLLAYVQNTLRFASAKEEDAALVAVPPYHVAGLANLLANLYMGRRVVYLPSFDPGEWLRTVRGEGVTHALLVPTMLARIVGEVRGDDAGTPTLRSISYGGARTPLPVLEQAMRIFPKAGFVNVYGLTETASSIAALGPKDHRRALESTDPKVRARLQSVGRALPGTEFQIRREDGTTAGAGEAGLVFVRGEQISGEYGGGNALDDGGWFATRDRGWLDADGFLFIEGRADDTIIRGGENIAPAEIEDVLLAHPGVVEAAVVGVPDPEWGQRIVAFLVGEGDPEEIRGWVRERLRSSKTPDAVVFRADLPKTDTGKTLRRVLLTELENTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLN2</accession>
    <name>A0A1H6DLN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85616">
        <property type="protein sequence ID" value="SEG85616"/>
        <property type="gene ID" value="SAMN04489712_11846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="11136" checksum="5D27CFA1AECF2F20" modified="2017-01-18" version="1">MPITLVRPRRVTALFRARVRGRRPAPPPWRPCGPQSADEVALAIALTARWMLVTGRRIDQVPLLHDLPGDQLIDFWSDDHVAGPHPPRPAADRREVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLY0</accession>
    <name>A0A1H6DLY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86427">
        <property type="protein sequence ID" value="SEG86427"/>
        <property type="gene ID" value="SAMN04489712_11981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="2 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1352"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="870"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG86427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="2174" mass="231484" checksum="471E3C0BDA0974AA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMA2</accession>
    <name>A0A1H6DMA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_119103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86527">
        <property type="protein sequence ID" value="SEG86527"/>
        <property type="gene ID" value="SAMN04489712_119103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="373" mass="39509" checksum="CEDD7DFA3877CD66" modified="2017-01-18" version="1">MLVPSVGCAVVGCGDVSTKYLRTLRAAPIIDIVACCDVLPERARRLAARCARAVSASLPEILADPAVELVINLTPPQQHTEITLRALRAGKSVYTEKPVATSPEELAEVLVMAGNGDAMLGGAPDTALGPAAQAARRAIDEGRIGRPLGASAALLTPGHERSCPTPEVFYRKGAGPLLDMGVYYLTMLVSLLGPVREVVGAHSRPSPLRVIDTGPRARTSFATEVPTHVAALLVFENREIVTLTASFEVWGTRVPHLEIFGTEGTLSIPDPNFYTGAVRLKAARSREWIPLPYPPDAPVGRGIGVIDMAHALRGLTGQRLTGGIIGHVVETMLAVEAEKTAATTLASRCDRPAPLRSAPSPTGCWWCEQCGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DML0</accession>
    <name>A0A1H6DML0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86478">
        <property type="protein sequence ID" value="SEG86478"/>
        <property type="gene ID" value="SAMN04489712_11993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="740" mass="82660" checksum="E27BFFFD4F0F72EC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP42</accession>
    <name>A0A1H6DP42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplS</name>
        <name evidence="8" type="ORF">SAMN04489712_12055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87028">
        <property type="protein sequence ID" value="SEG87028"/>
        <property type="gene ID" value="SAMN04489712_12055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG87028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="13263" checksum="D771A76C3570FAE8" modified="2017-01-18" version="1">MHTLIQEIEKAALRADVPDFRPGDTLKVHVRVTEGNRSRIQVFQGVAIRRQGGGARETFTVRKISYGVGVERTFPLNSPSIEKIEVVTRGDVRRAKLYYLRNLRGKAARIKEKRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRS0</accession>
    <name>A0A1H6DRS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding universal stress protein, UspA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88067">
        <property type="protein sequence ID" value="SEG88067"/>
        <property type="gene ID" value="SAMN04489712_12168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="144"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="30856" checksum="BAEC07A281B0B34D" modified="2017-01-18" version="1">MGRYSQVLVGYDGTKESERALRWAVEEARRRRLPLTVCHAWRWPYPISYIDYEGAAIIKRMGENLLRHGTALAQNLAPGVPVRHRLMDGPTASALLHHADDGLIVIGSHEQSELPVGSSALQIPARARCPVMVVRDPAQATEGRVVAGVDGSAGGEAALEFAFEEAALRGWRLDAVHGCWEPASVADSEIALFADKVTLEHVCGARLQRAVAPWLVKCPQVSVRTFMPMEEPRRALLDAAEGADLIVVGDRGEGGLHPQLLGATTLAMLQLSPCTVAVVHPLHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRS8</accession>
    <name>A0A1H6DRS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Excinuclease ABC, A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88052">
        <property type="protein sequence ID" value="SEG88052"/>
        <property type="gene ID" value="SAMN04489712_12165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="458"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="492"/>
            <end position="499"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG88052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="759" mass="81823" checksum="A8C8CDDE5B1FE26E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSD8</accession>
    <name>A0A1H6DSD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88179">
        <property type="protein sequence ID" value="SEG88179"/>
        <property type="gene ID" value="SAMN04489712_12192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="11187" checksum="00380BBAC0BCFCC5" modified="2017-01-18" version="1">MSNLPNVPRPGEGSGRTEPGMTQMRVRLLAELAIALVERGQASRMVVETSGQTALMLRPVWGQSAVGVVIRARARWAYLWDGTHRHPADDMAAIRAAAAALAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT17</accession>
    <name>A0A1H6DT17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type branched-chain amino acid transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88507">
        <property type="protein sequence ID" value="SEG88507"/>
        <property type="gene ID" value="SAMN04489712_12217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG88507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="665" mass="69212" checksum="496916E8CB3EF7DA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUY4</accession>
    <name>A0A1H6DUY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, sugar porter (SP) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89167">
        <property type="protein sequence ID" value="SEG89167"/>
        <property type="gene ID" value="SAMN04489712_12335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="107"/>
        </location>
    </feature>
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        <location>
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            <end position="141"/>
        </location>
    </feature>
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        <location>
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            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="262"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
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        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG89167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="462" mass="49028" checksum="B76BAAFE8E1DA6F6" modified="2017-01-18" version="1">MGGFLFGYDTSVINGTVDALKSEFGLESVAVGFVVASALLGCAVGAWFAGPLADRFGRVRVMLLASLLFVVSALGSALAFGPADLTFWRVVGGLAVGAASVIAPAYIAEIAPAHLRGRLGSLQQLAIVTGIFAALLADYFIARVSGGAAGEFPLGGAAWRWMFASAAVPAVIYGMIALAIPESPRYLVKKRQEGRARQVLGRLTDGDVDGKIRDIARTLREDRPVRLRDLRGPRLGLLPIVWVGILLSVFQQFVGINVIFYYSSSLWQAVGFTENDAMLTSVITSITNIVTTLVAIALVDRIGRRRLLLAGAAGMTVTLAAMAIAFSTARIVDGQPELGPVAGPVALVAANLYVFAFGATWGPVVWVMLGEMFNNFIRAAALAVAASAQWIANWVITTTFPAMADIGLSFAYGFYTLSAALAFVFVYKSVRETKGRELEDMDEVAGAPVVTRAGRTRRVKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWZ7</accession>
    <name>A0A1H6DWZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89857">
        <property type="protein sequence ID" value="SEG89857"/>
        <property type="gene ID" value="SAMN04489712_12492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="127" mass="13092" checksum="28B98AEFE350AA52" modified="2017-01-18" version="1">MRNIPVDVSALTFVCVSPPRPKLVDQNTGEVRVDRNGQTVYTVGLSAADEAGNVDLVKVAVAGDPAVSIGQVVTPVGLVAFPWEQQLGGRMRWGIAYRAEQIIPAVQAAPASVGSVGSAVPVSADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX72</accession>
    <name>A0A1H6DX72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89868">
        <property type="protein sequence ID" value="SEG89868"/>
        <property type="gene ID" value="SAMN04489712_12495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="29084" checksum="F3A185B15E7E1DF8" modified="2017-01-18" version="1">MTRRVLPVVADSGPVMILAAIAAAGSFTHIRDTAREHGQHGWMAWAVAVCIDLTCVMAARERQRDKRTARATRPLSWPTLVLVGGILLSLAANLAQAEPTVWGWVTAGTPAAAFLVAVSMLERRAAHRPAARPAARSNASAPDGLAVPPSFGCPADSSPSSSPSSSPVSAVRDRVRPELAAPGPALVEDGQTEVPLPAADPAASSRPDDSGRPAPARPASATGPAGLAGPLVEFARRVADEHHTRHGRPITRDALRARLGVSNQLASELLRQIRDQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ82</accession>
    <name>A0A1H6DZ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglutamate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90076">
        <property type="protein sequence ID" value="SEG90076"/>
        <property type="gene ID" value="SAMN04489712_12531"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG90076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="284" mass="28273" checksum="64317CC1C84735F1" modified="2017-01-18" version="1">MPAQRSPLGPLVVKAGGHAAVDPDAVCADVAAVARTGRPTVLVHGGSADIDRLGARLGVPARRLTALDGIITRHTDAATLEVVQLALGGLVRPRLVARLHAHGVRAVGLSGVDGGLLRARRKAAHRAWEDGRRVVVRDVHSGRITGVDAGLLHTLLAAGVLPVVGPPALAEDGRPVNADADRVAAAVAGAVGAGTLVLLTGAPGVLADPADEASVLAACAVPAAGPPPYRGGGMGLKLVAAREALAAGVPEVLVADGRRDRPLSRALAGAATRIELAADEGGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E197</accession>
    <name>A0A1H6E197_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RHS repeat-associated core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91398">
        <property type="protein sequence ID" value="SEG91398"/>
        <property type="gene ID" value="SAMN04489712_1295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032722">
        <property type="entry name" value="Deaminase_XOO_2897"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14440">
        <property type="entry name" value="XOO_2897-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296423" evidence="2">
        <location>
            <begin position="31"/>
            <end position="2365"/>
        </location>
    </feature>
    <feature type="domain" description="HintN" evidence="3">
        <location>
            <begin position="2088"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1888"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2052"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2069"/>
            <end position="2085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG91398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="2365" mass="252573" checksum="40D3BB05966AE9AA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2U3</accession>
    <name>A0A1H6E2U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91434">
        <property type="protein sequence ID" value="SEG91434"/>
        <property type="gene ID" value="SAMN04489712_12916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="177" mass="19801" checksum="175E8E449CC3508D" modified="2017-01-18" version="1">MIEISYPSRVSDSHRPRGADGHPAPDGPSTDLQTFAGQLRRMNSEFNRMAHEFARAQNLHHTDVLALIAILDGDDQGSPLTPGRLCERLNLTSGAVTACLDRLERSGHIRRTRDGSDRRVVHLHYAPHGKAVARAFFRPLARSTEAARSRFDEGELKTIVRFLIAMNEELAEQRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E375</accession>
    <name>A0A1H6E375_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92148">
        <property type="protein sequence ID" value="SEG92148"/>
        <property type="gene ID" value="SAMN04489712_13239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="26822" checksum="A1766F21E721C7BD" modified="2017-01-18" version="1">MQVADSKSDLRRRLLSARASMDARERAAAGRALRDTLLGLPELEMAASVAAYVSFGAEPETRSLLFALWKRGTYVLLPRLLPDGDLDWASYEGPDSLAPAPRFGSGPAGPGLRTPGAGTPESPGAGTQAEPGFPGASDTETHITPGPGLQPTPQEASEARPPGGSGAIGMLEPTEPPRGPDAIRAADVVLVPALAVDGTGLRLGRGGGSYDRALARVGSGILTVGLVYDHELVDTVPAEPHDQRLRAVVTPSRGLVRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E393</accession>
    <name>A0A1H6E393_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92090">
        <property type="protein sequence ID" value="SEG92090"/>
        <property type="gene ID" value="SAMN04489712_13219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="54" mass="5925" checksum="C14FDCD3F1FBDDEA" modified="2017-01-18" version="1">MNASLANPRRTRIDAWPKPPQAEDPATRRPDWLNGSVPHTPAEPINGVPVADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5H0</accession>
    <name>A0A1H6E5H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92932">
        <property type="protein sequence ID" value="SEG92932"/>
        <property type="gene ID" value="SAMN04489712_13618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="26806" checksum="DCCA8D5F164487B7" modified="2017-01-18" version="1">MTNLDGRVALVTGAARGIGAEIARTYARAGARVGVLDLTEDLTRQTVAAIADAGGQAIGLGADVADAGQVEQAVQRLVQEFGGLDIVVNNAGVTRDNLLFKMTEDDWDTVMNVHMRGVFLVTRAAQRIMVERRYGRVINISSTSALGNRGQANYSAAKAGIQGFTRTTAIELGPFGITVNSIGPGYVDTEMTRATAERLGVPVDRRLAEVAATLPMRRVGRPADIANAALFLAADESGFVTGQVLYVDGGRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E694</accession>
    <name>A0A1H6E694_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93318">
        <property type="protein sequence ID" value="SEG93318"/>
        <property type="gene ID" value="SAMN04489712_13818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="74" mass="8835" checksum="1FAC910FC637385D" modified="2017-01-18" version="1">MTRTPGTATQKLRGASGPDELWTVEDLSGFLKKPTSWVYENYRELFPYYRMGQAVRFDPEEIRAVLRQRYRFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E840</accession>
    <name>A0A1H6E840_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_14219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93988">
        <property type="protein sequence ID" value="SEG93988"/>
        <property type="gene ID" value="SAMN04489712_14219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG93988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="227" mass="25830" checksum="4D3B6AD71A67FA51" modified="2017-01-18" version="1">MPAEKTAAGRRTQAVERVVGELRRMIMSGELLPGQQIRQENMAERLGVSRLPIREGLRQLTADGLVSHTHNVGYTVARLSQAEFDQIYLMRNLLENEVIRCLPTPTDAQLQRIIDLNAEVITAAEQLDLVEMRLRNHDFHFEIFRLSDLGLVIDEIERLWNWAAPYHAVYLFSPDSRRAVLEEHEAMIEALRNGDNIRLAQLMDQHRHGSETQIGLILGAGPIARPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8R2</accession>
    <name>A0A1H6E8R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000044">
        <property type="protein sequence ID" value="SEG94208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94208">
        <property type="protein sequence ID" value="SEG94208"/>
        <property type="gene ID" value="SAMN04489712_1448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="375" mass="40940" checksum="EEBCEA40CC4D147F" modified="2017-01-18" version="1">MSTSTSDLVVGADETAALAVVGPNDLTALTGAPRTFSPHGYVRSDGRNVVVSYSASNRIRELALEGDHWASYDLTKEAGDAPRGFAPRGYVRSDGVTAVVYLGLSSDGHHMHELALIGNAWRHTDLTAKTGAIGGGTMRPYVRHDGTTVIVYRGPDGHIHELAREGNTWRHYDLTIESGAPTDPQRLPSPSDQPIGYARSDGSSAVVFRSADGEIRQLKLTNVWEHRNLTNDAGDPKATYGLAAAVRHDGVNVIFYAGQDHHLHELSLDPSGEWQHNDITALFNGPQLGDGAHIEVFPIFRSGRAMTSVVYDDADRHLNEFRLDGTWKNTDRTTQTGAPTLEPFMIAAYQRTDGVTAFLFSSHPNPDHHIFEITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EDI3</accession>
    <name>A0A1H6EDI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000059">
        <property type="protein sequence ID" value="SEG95016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95016">
        <property type="protein sequence ID" value="SEG95016"/>
        <property type="gene ID" value="SAMN04489712_1592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG95016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="14445" checksum="89F565CA67925259" modified="2017-01-18" version="1">MSTPVSPISPVSIATTDPRVLALARARQQLAHRGMLHPAWEELTEEERTMALPEARNWLEAAVAAGLAPDLDDADTAFVVAEALREFAHRQRGEADQVAADVAAGDDLAAGAEVEQRRRWAEIAETVLDRIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EDV1</accession>
    <name>A0A1H6EDV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_1681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000068">
        <property type="protein sequence ID" value="SEG95136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95136">
        <property type="protein sequence ID" value="SEG95136"/>
        <property type="gene ID" value="SAMN04489712_1681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG95136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="418" mass="46350" checksum="5FA718CD1D5FD054" modified="2017-01-18" version="1">MTNHDEDEPQGGLDVQLAAELVAKAKAEGVSLVGPDGLLAGITKTVLQAALEAEMTEHLGYERGEHPAAPTGNHRNGSSAKTVSTEVGPVQIQVPRDRAGEFTPRIVPKHARRIAGFDEAIVSLYAKGLTTGEIRAHLAEIYQVEVSRDLISRVTDKVVEEMEAWRARPLDAVYPVVLIDALYVKIREGQVANRPVYVALGINCHGERDVLGLWVGTGGEGAKHWMTVLAELKNRGVADVCIACCDGLRGLPEAIEEIWPQATVQQCVVHLVRSSLRYASKAHWGRLTRDLRQIYTAPTEAAAEQRFTEFEAEWGDRYPAIIRLWRDAWPSFIPFLAFPAEIRKIVYTTNAIESLNARFRQATRRRGHFPTEQAALKVLYLVIRQPLKNRPNVTGRTPGWKAALNALSLHYGDRITVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SAR6</accession>
    <name>A0A1H5SAR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47585">
        <property type="protein sequence ID" value="SEF47585"/>
        <property type="gene ID" value="SAMN04489712_101135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF47585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="6755" checksum="A7286AFAE6762AB6" modified="2017-01-18" version="1">MRVTVNGQSRELPEGTTVAAVVATVTEATTGVAVAINDEVVSRGSWAGTAVRDQDRVEVLTAVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SCZ2</accession>
    <name>A0A1H5SCZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotate dehydrogenase electron transfer subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="5">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48486">
        <property type="protein sequence ID" value="SEF48486"/>
        <property type="gene ID" value="SAMN04489712_101161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DHODB_Fe-S_bind" evidence="6">
        <location>
            <begin position="243"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF48486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="31690" checksum="53517BC9E6B9F59E" modified="2017-01-18" version="1">MTDTAGPGSGRAVGLRTSAIVLTVRQVQDYHAMTLVAPAVAERFRPGQFVALAVGGEHTGRLVRRCLAVYEVKPDYGGTVEVVFDHRGSRDPGTGWLAGRRARDMVDVVGPLGRPFRLPRDPVNCLLVGGGPGAAALFALADTLRRRECRVHFLLGGRSAPAVFGARSARRIGDSATVVTEDGSLGDTGTVRDVLPRVIEESAADVVYACGPTGLLRSVSAVATEYGLPSQVSVEEFLQQTGACGVGLCMTCVLPIIGDDGVTRMARACTDGLVMRGDRVRWGDLGTIPLDALGAPRALGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SVD6</accession>
    <name>A0A1H5SVD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53831">
        <property type="protein sequence ID" value="SEF53831"/>
        <property type="gene ID" value="SAMN04489712_101357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF53831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="322" mass="34237" checksum="D1CAB0877448402D" modified="2017-01-18" version="1">MFGNFIDQFWPSTIDGLSLGAIYALVALGYTMVYGVLRLINFAHSEIFMIGTFAALATLNAIGLSAPVGGLALIGLVLMLAVVAGLVSGASAVALEFVAYRPLRRRGASRLAALISAIGASLFLQQLFARVLIPWWFDLPKEKGALPIPKHFTETVDLLSIGDFIIRNDKLFVILGAIVMMIALDQFVNRTQLGRGIRATAQDPETAVLMGVNIDRVVSATFMIGGVMAGVAAALYLMRFGETNYFVGFLLGIKAFTAAVLGGIGNLRGALVGGLTLGLIEMYGSVIFGSAWQDVVAFSVLVLVLMFRPTGILGESLQQARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SYC0</accession>
    <name>A0A1H5SYC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55556">
        <property type="protein sequence ID" value="SEF55556"/>
        <property type="gene ID" value="SAMN04489712_101411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF55556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="334" mass="36804" checksum="D3BB5F00BF9AB492" modified="2017-01-18" version="1">MVDMTSPRPRPVLDPDIPAADRDLLRAPSTRLVAAARPAPARPRPGPARLLARALWIPLLALFYGVLPGGWITLFLLASLDEEDLLTGVFRWGRTAVLAMLVLPVVQVTLILLGWEPAAVLVAAAGFTGWTVGIARRLGEPPAARAARVHHGRYLTAGDFDRPAAGLLSRAQRAIDAVQGSRAQRAGLLDGVGNAVALPYQEWEIAEALAEHTRLRREHEAQRPDRLSEPVRALLEPQRRALALSVRSVTERVEALEDYARRVRDLDGAYHEWQVLRRLPEQNARHRDLLARTVRDDLAREEIDRLTGDAQRAETALHDSITSAVQAARAVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TEX2</accession>
    <name>A0A1H5TEX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61356">
        <property type="protein sequence ID" value="SEF61356"/>
        <property type="gene ID" value="SAMN04489712_101592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="65"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF61356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="23901" checksum="D0703856B1E4ABB9" modified="2017-01-18" version="1">MPRLRQVSRAEATDKLVLFFYDRLFGEDRDPVAEPGTATGSPGDWWTVFALDPAIFKHCVQGFNVYRNVKLDPVLRELGQTRAGWARGSQFVFSQHCKQMRALGVPDEKVQAVAHWEVSDLFDELERAVLAYTDALVLGGGRVHDEVFNTLKKHLPDEQILELTYTTCLYEMHATMSRALRTEFDDRDDPIVEVPAPEGYGARDIADDITGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TL64</accession>
    <name>A0A1H5TL64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvP</name>
        <name evidence="9" type="ORF">SAMN04489712_101664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63504">
        <property type="protein sequence ID" value="SEF63504"/>
        <property type="gene ID" value="SAMN04489712_101664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF63504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="949" mass="101280" checksum="4DD318B3139F8FF0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TUU8</accession>
    <name>A0A1H5TUU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP:flavonoid glycosyltransferase YjiC, YdhE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65821">
        <property type="protein sequence ID" value="SEF65821"/>
        <property type="gene ID" value="SAMN04489712_101732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="DUF1205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="DUF1205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1205" evidence="2">
        <location>
            <begin position="184"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF65821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="41523" checksum="0E18D906F1FBABD5" modified="2017-01-18" version="1">MRVLFVASPGLGHLFPTVPLAQAIRAAGHEVRYATGGLSVAASEAGFTVFDVTPGLDYAPIFIEGGGGDGPQPIHADDPEDEMLARLFGRVSGVMVDGVLDAARAWSPDLIFAPPLQGAGPLAAAALGIPYVDMPVGLYDARHDLPDMVREAMSEHYERHGVTGRPPATARISTCLPSFVEHLPAERRPNDAWPMRHVSYNGGSILPDWLRRRPERPRIAVTLGTIEAQWGGIAVLAPLMAAAGAVDAEFVLTLGGGDVSLLGTLPPNVRVVEWAPLDALLETCEAVIHHGGSGTSMTAIQSGIPQCVLPQGSYQHSDVDVIAELGIGFLADAASLGAAECYTLLKDEAMRDAARRVRDELRSMPAPAELVPRLAELAGQGAAVAAADARGDGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TWI2</accession>
    <name>A0A1H5TWI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RibD C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67110">
        <property type="protein sequence ID" value="SEF67110"/>
        <property type="gene ID" value="SAMN04489712_101771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="12"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF67110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="214" mass="24069" checksum="11CB727B8142A895" modified="2017-01-18" version="1">MAQLLRVQNFNVSSDGIGAGEDQSLERPFGHVEPEKLFAWAGATASWSMRTDPGGSRGLDDYFIRDYAHNIGAEIMGRNKFGPQRGPWKDHEWRGWWGDEPPFHTPVFVMTHHERPSFTLSDTTFHFVGGDPATVLEQAREAAQGKDVRLGGGVTTIRQFLDADLVDTMHVVVSPMKLGSGLRLWESPDELLDRFHHEVVPSPSGVTHHLFWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U1T5</accession>
    <name>A0A1H5U1T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68970">
        <property type="protein sequence ID" value="SEF68970"/>
        <property type="gene ID" value="SAMN04489712_101835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF68970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="195" mass="20174" checksum="3491790EF09C5141" modified="2017-01-18" version="1">MGEPRIVDLDAPGLDWTDVTMPAASAPVRLVRLHADAATGSSVSLVRFPAGWTRPGTGHYTCAEEFTVLDGRISVSGTARSAGAYAYLPELTTRTDSFVGAGGCLAVAWFSGPPRWKDGVAEEAPGPGAETGRTHSALLGSLAELSGRLPGIGDGATGLDATFLDARVWAYAPDAASLPDLPGRVLVRRWPASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UUN5</accession>
    <name>A0A1H5UUN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78773">
        <property type="protein sequence ID" value="SEF78773"/>
        <property type="gene ID" value="SAMN04489712_10237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF78773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="196" mass="21112" checksum="A68555986A95E6AD" modified="2017-01-18" version="1">MSASAAPVRPATPADAGPAVETLVRAFADYAFTRHVIAADGYTERLRTFQGMFLERVGLVHGRVWVSDDLRAVAVWTTPDADPTPAFEELAPRVGEIAGNRAAAYQAAEEALAPYRPAGPAWFLATVGVDPDAQGRGLGGAVVRPGLEEAERAGVPAYLETSAERNVRFYERLGFEVEAEAELPGGGPRTWCMWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VDM6</accession>
    <name>A0A1H5VDM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85294">
        <property type="protein sequence ID" value="SEF85294"/>
        <property type="gene ID" value="SAMN04489712_102274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF85294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="26458" checksum="80F57E9306B65C12" modified="2017-01-18" version="1">MIRIIAVDDHTLLREALCETLRAEDDFDVVAQAGGADGIVELVAAHRPDVVLLDMEMPGHAPEETIRTLTRSFPGIKVLVLSMHDDISLIRHMLLTGACGYLHKSIPREHLLSAIRRVVRGEDGLALVLSATGLTRPAATADGLLSARERQILAHVAEALSNRQIATRLGITEGTVKRHLRNVYGKLGAVSRIDAVNRAVAAGLIDAPAGARLGRAAADAPADTQTRALPSPRPHDRHHAHRPGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VQ24</accession>
    <name>A0A1H5VQ24_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="10" type="ORF">SAMN04489712_102403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89116">
        <property type="protein sequence ID" value="SEF89116"/>
        <property type="gene ID" value="SAMN04489712_102403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="13"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="287"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF89116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="366" mass="38803" checksum="BA010B5F4091590D" modified="2017-01-18" version="1">MPADNTTAKKTPLYDVHRELGANLVDFAGYLMPLRYASETAEHRAVRTGAGLFDLSHMGEIFVEGPQAAQGLDYALVGEPSAVPIGRARYTMICAPDGGVLDDLIVYRLAEERFLVVANAANIATVHRALAERVASGFQAEVADRSDEYALIALQGPQSQAILSQFTDAPLDGLRYYAWLSGRVAGVDALIARTGYTGEDGFELFVAAADAVRLWNELALVEGVLPAGLAARDTLRLEAGMPLYGNELTAETTPYEAGLGRVVKLGKPGDFVGRKALAAYADTPPGRTLVGLVARGRRAPRKGYEVVRADGTVCGVVTSGAPSPTLGKPIAMAYVDSGAAEAGLAVDVRGRHEPVDVVDLPFYKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W0F4</accession>
    <name>A0A1H5W0F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92267">
        <property type="protein sequence ID" value="SEF92267"/>
        <property type="gene ID" value="SAMN04489712_102517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="6">
        <location>
            <begin position="122"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF92267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="25619" checksum="DEDCE7D56536E0D9" modified="2017-01-18" version="1">MAAVRDAVDAGELAAPVPAEAPLSGFGVGEYGTPVALRLAARERRPAAEVAKTIAGRLVGRPGLRDVRVTGPGFLTITVEEPGALAAGVIAAGASYGRVEGTVLEGGWPDRPRTFDNPGFSVRYAYARAAAVQRRAEDLGIPLGDPRFLQEPREGVLLALLAELPSRVEQAVRERDAVPLERHLERVADAYHRVFEQCSALPAGDEKPGAVHAARRTLAEAVRIALTNALNMIGESPRERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W506</accession>
    <name>A0A1H5W506_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94306">
        <property type="protein sequence ID" value="SEF94306"/>
        <property type="gene ID" value="SAMN04489712_102583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021424">
        <property type="entry name" value="PorA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11271">
        <property type="entry name" value="PorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF94306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="42127" checksum="A48B49D87A8F0C59" modified="2017-01-18" version="1">MRRPLGLVLVGLGSFLLALAPLVRFYVTGQVVRAPLNFYQATELEARDAQYYDLLARKVRTGVTLAAANTVRGDTRANRGDDGIAVWDSITEIYDKDRRKQVEFQTYRIAFDRRTSELVNCCGSHVGGDTRVRMSGYGLLFPLGNVQRRDYPVFDMSTRRSLPMRFDGEERIHGLNAYRFVQQVPNYRTAKIDLRPTGEMLGLRGAADRRRTFKVDRYFSATITVWVDPRTGIPIKHDQNIRSTVETEDGRGKMVVAAARLVTVDRDQRRNVDTSNGYAFQRRLVESVLPIGGLAGGLVLLALGAFISMRAPKDGGTPRGGVTRKPDGRFGASGGPSGGPAAGGGSSGGGSSGGGPSGGGPAGGPAAGGPARSWRTPAPRPSGAGARRSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XA54</accession>
    <name>A0A1H5XA54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall-active antibiotics response 4TMS YvqF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08227">
        <property type="protein sequence ID" value="SEG08227"/>
        <property type="gene ID" value="SAMN04489712_103146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="113"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG08227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="24289" checksum="72B2D699D991A58A" modified="2017-01-18" version="1">MNNPTPQPDRPQPRRPSPQVPSGSVRASDAEREAVVELLRIASVEGRLTFAELTERTEAAYGAVTRGELEKITADLPGVGAPGAEPAPALQTRRFTAVMGDARERIVGRIEEELNALSVMGSVVLDLRDAQVPRGEVSIVATAVMGDVKIIVPDGVEVRMGGYAVMGDRRVRTRRPEPGHTVPVVHVRAQSVMGDIEIVDDEHHAPIRRAFTTWWEDRRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XI61</accession>
    <name>A0A1H5XI61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv1855c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11441">
        <property type="protein sequence ID" value="SEG11441"/>
        <property type="gene ID" value="SAMN04489712_103267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG11441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="33718" checksum="48C493C2CEC945EE" modified="2017-01-18" version="1">MRLRIFTEPQQGATYDTLLRVARATEELGFDAFFRSDHYLKMGDVSGEPGPTDAWITLAALARETSRIRLGTLMTAATFRYPGPLAISVAQVDQMSGGRVDFGVGTGWFEAEHTAYGIPFPALKERFERLEEQLEIITGLWGTPEGETYSFEGAHYRLADSPALPKPVRPGGPPVLIGGTGAKRTPRLAARYAKEYNVPFNRADETKAAYERVRAACEEAGRTEPMVYSAAQVVCCGRDEAEIARRAAAIGREVSELRENGLAGTPGELLDKLGRFAEFGTECVYLQVLDLSDLDHLELLAGEVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XNU0</accession>
    <name>A0A1H5XNU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13362">
        <property type="protein sequence ID" value="SEG13362"/>
        <property type="gene ID" value="SAMN04489712_103338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="4">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="3">
        <location>
            <begin position="164"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG13362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="316" mass="34038" checksum="7CA7AB0452328ACF" modified="2017-01-18" version="1">MTTLDRPLRSAPARRPARGLFSLGDVDEATVRHLVERSVALYRRPDLHDVPLAGRFVGILFTRTSTRTRTAFTVGTARLGGTPIAFGPQDLQTNTGESLEDTGRIFGAMLDALVARTAGPVHELRELSRAGCLPVLNAMAAEEHPTQGICDLATLLLHRGDLSGIRVLYVGEGNNTATALAQGLAHIPEVSITFYTPPGYGLPPGLASGGAITETHSAEELPAEVDVVYTTRWQTTGTSKAAASWRETFRPFYVDEAFLDRWPNALFMHDLPAHRGEEVAGAVLDGPRSIAWSQARMKLASAMATLEWAIPPHGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XW16</accession>
    <name>A0A1H5XW16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkylhydroperoxidase family enzyme, contains CxxC motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15852">
        <property type="protein sequence ID" value="SEG15852"/>
        <property type="gene ID" value="SAMN04489712_103433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG15852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="21747" checksum="32BD132DB35298BA" modified="2017-01-18" version="1">MSTIGFLGVPEHTPEAQRLFDDDVDELGFVMNISRLWAYRPEFLAGLFDLMQGLGRMHGLTLRQRGVLVAACASAFGDSYCSLAWGCKLAEAADPQTAAGVLRGDDGGLTPGERALAAWARKVARDPGRTCAADVQALRDAGWDDAQIFAITAFVALRVAFSTVNTALGARPDAAFRTIAPGAVLDAVTFGRPVEEPPAEEPPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YQV7</accession>
    <name>A0A1H5YQV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26384">
        <property type="protein sequence ID" value="SEG26384"/>
        <property type="gene ID" value="SAMN04489712_104132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="245" mass="26319" checksum="3ABAAA228DB18A8C" modified="2017-01-18" version="1">MCQAFPWRRCIETRSRACGITITRSPATTRKAQTPRVRPGRPLRVQLSGGVGLSGTGQRSFASVRLCWLGAAVGMACGVLLAGCSEESPTVALPTQTGSALAVPSSSPPSTSPESEAEVIKDAYEQFAALLDRAHTLPAASRRQHLSTYMTDPQLSRVLDRIEKLRADGLVAYGTTVVHIKSVLIDGNDATVHDCQDTRNAGLMRADTHKKISRGVKEENIKSYMLKGADGRWRISKSVALGEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YRL4</accession>
    <name>A0A1H5YRL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26312">
        <property type="protein sequence ID" value="SEG26312"/>
        <property type="gene ID" value="SAMN04489712_104129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG26312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="27593" checksum="C787FBFB85CAE7BB" modified="2017-01-18" version="1">MALYCLISPGGAPGVTTTALGLALTWPGKVLLAECDPAGRRVLPGFMAERLRQAPGPGLLGLAMAMEPDPHAAAASLAEYALPLGDGEAELLHGIRDPRHVQQLASLWRPLAEAFTAVEGDVIADLGRVGGPDTPVALLAAADAVVVVLRRTLAQVDAAVPRLEVLRGLVGEQVPVGLCVIEDGSYSIADVRRVLELPVFAELPYAMADARVLSDGAPPRLTFKTSLLMRAVDGLGKRMRKAVAERLVPDGEPSTSAPVTLGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXG9</accession>
    <name>A0A1H5YXG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28724">
        <property type="protein sequence ID" value="SEG28724"/>
        <property type="gene ID" value="SAMN04489712_104235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023116">
        <property type="entry name" value="Phosphonoacetate_hydro_insert"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG28724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="462" mass="50764" checksum="CB65701426A8921E" modified="2017-01-18" version="1">MSTASPRPLVVIDVVGLTPRLLAHMPNLTKAMKAEATLGTVLPAVTCSVQSTLLTGALPSEHGIVGNGWYFRELGEVFLWRQHNALVGGEKVWDAARRVYPGYKVANVCWWYAMGAATDFTVTPRPIYHADGRKSPDCYTNPPELRVDLTRELGRFPLFSYWGPKAGIASSKWIVEASRLLLRREKPDLTLVYLPHLDYDLQRFGSEGPEAVAAAQEIDAELAPLLADADAQGAVTVVLSEYGITNVSRPVDINRVLRRAGLLDVYRQAGMEYLDPWTSRAFAVADHQLAHVYVKDPADLPKVRDMLAEVPGVDEVLDQAGKAAHGLDHSRSGELVAVAEPDSWFTYYYWLDDARAPDFARMVDIHRKPGYDPAELFMDPSDPLVKAKAGLALARKQLGFRYTMQVVPLDPSLVRGSHGRIPATPDDGPVLMCSEPLDRDTYAATEVKSLLLSLAGLIPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZR7</accession>
    <name>A0A1H5YZR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinol monooxygenase YgiN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29270">
        <property type="protein sequence ID" value="SEG29270"/>
        <property type="gene ID" value="SAMN04489712_104260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="3">
        <location>
            <begin position="320"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG29270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="428" mass="45507" checksum="642611EE4F9C286A" modified="2017-01-18" version="1">MVQGIPALLATLGALAATGLLILRAKKERLPYLIAWCLTMGGISVALIGMTLGFLVGFGGFLFRLMEVGGALIAPVWLALGMTVLIAGVMQLRFACWLFGTSYSVVAVVILLLDPLKGSFDKSLPNPGRHYDSLPLLLIDVAHGVAVIALVACLVVIALRAGKQDRAAYELLMPVALVALAGVLVVSGTRGFLPGFLSALALAGAAGLVWFGVTRMLPETGTDEDGYDEEYQEGEYDGEYAAGYDDGYHDRAPADQGYEIPTGYDEQPYADPAATQVQPPAHARPPVPPQAKQPPPPAMPPAMPAGARLPAGERPGTPLCGQITVYTLMDGRGEAFDRLAAEAVRAAREAEPDILIFTCHEVPGAPSQRIVYRLFRDQAAFAEHQRLPHVQRFAAESRPYVAATNVIELSLTAGKVVSLPAPTVQDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z0T2</accession>
    <name>A0A1H5Z0T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_104259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29247">
        <property type="protein sequence ID" value="SEG29247"/>
        <property type="gene ID" value="SAMN04489712_104259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG29247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="25110" checksum="77AC851125D0FEB3" modified="2017-01-18" version="1">MRSVPLEIPPPAISWPSPLIGALPRRRVGRPATPGTADDEIKALVLRARDGEADAFGALYDHYVELVYRYVYYRVGSHPLAEDLTSETFLRALRRIGDFSWQGKDFGAWLVTIARNLVADHFKSSRFRLEVCTAELLEPEGAGPDRSAEDPERRVLEAMTNRALLAAIRRLNSEQQECVVLRFLHGLSVAETALIMGKKTGAIKALQYRAVRSLGRMLPRDLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z2J0</accession>
    <name>A0A1H5Z2J0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ORF">SAMN04489712_104307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30414">
        <property type="protein sequence ID" value="SEG30414"/>
        <property type="gene ID" value="SAMN04489712_104307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="49"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG30414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23689" checksum="054FA6C833C5482C" modified="2017-01-18" version="1">MFGFFKTEMVSPEAALPGRDTPMPVPPAHEVLGTPLTPPYPEGSEIADFALGCFWGAERKFWQTPGVITTAVGYQGGYTPNPTYEEVCSGRTGHAEAVRVVYDPAKVTYEQLLRVFWESHDPTQGMRQGNDVGTQYRSAVYTHSDAQQKTAEASRDAYQRSLTAAGHGPITTEITPATPFYYAEPYHQQYLSDAKNPNGYCGLGGTGVSCPVGIAPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z3I8</accession>
    <name>A0A1H5Z3I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH dehydrogenase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_104299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30205">
        <property type="protein sequence ID" value="SEG30205"/>
        <property type="gene ID" value="SAMN04489712_104299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="145"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG30205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="516" mass="54511" checksum="D9345541F6192B8D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZCJ8</accession>
    <name>A0A1H5ZCJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_104456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33455">
        <property type="protein sequence ID" value="SEG33455"/>
        <property type="gene ID" value="SAMN04489712_104456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="258"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG33455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="471" mass="50515" checksum="0966217A4F3A5944" modified="2017-01-18" version="1">MVAGFCAVALLSSVLASGLAYVLVRRAILQRTQDAVLAEVRETVARTVPPELPPDAGHAVAADLERALTKQDGRTRAYAVALPLDREVPLPHEVGPQLHVPVGREFARRAARGMVFQRVVHDGRPYLLVGTHVTGYRTTVEEPQRTTPPIVFVSVSLQREEADLRSFTRAVAIADVMALAAAFVLALLATRSVLLPVRQLGTAARALGDGRLETRLRVRGRDELADLARTFNGTAEALERTVTELRAMEAASRRFVADVSHELRTPLTAMIAVTDVLAEEGGASPAGGTAARLVVAEVRRLGVLVENLIEISRFDSGAAALVPDDLVVAEAVTATLAARGWSGQVPVRGPDDLVARLDPRRFDVIIANLAGNALRHGAPPVRLDFRPASRRDRPGFELTITDRGPGIPDDMLALVFDRFVKAEAARTRSEGSGLGLSIARENARLHGGTLEAANAAEGGAVFTLWLPLDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZEP4</accession>
    <name>A0A1H5ZEP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34550">
        <property type="protein sequence ID" value="SEG34550"/>
        <property type="gene ID" value="SAMN04489712_104504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7044" checksum="3D734F6EB60A7F9A" modified="2017-01-18" version="1">MARRIRHRFDPGAPVAGLFFLAVAGVFLAGGLSGEPVVPLEVLVAALLIGLGVVGIVRVLSAGRRRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZGA6</accession>
    <name>A0A1H5ZGA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein YgaE, UPF0421/DUF939 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35120">
        <property type="protein sequence ID" value="SEG35120"/>
        <property type="gene ID" value="SAMN04489712_104532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG35120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="42361" checksum="E6736278EF880F9E" modified="2017-01-18" version="1">MARLGGADAHRWCSAAGRAVRGACGRVRENAWLVLQGTAAATLAWLIAKHLVHHHQPFFSPIAAVIGLNAARGGRGLNSVRLLVGVVVGIAVAELALYVGTGYRALAIAVFGSMTIAVMINAQRIVIGQAAAGAILTIALGYPEAGGQRLVDAFIGAGVALTFSQLLFPSEPIGLLRRAEAAALAGMADGLEQTAEALEHEDVEPVCRAIARLRDASDRLTDLGDARQRSRYIRHTLLWWRRAEVIARESAEAERLDLLGSSCFALGRTALAARADERAELAPLVRELAEAVRVLARAPGDHDVRRRAARGAMHILHRLSELSETYSLLTTGRTLVRMAATDVLLFAGVDRETAIGRKETDMENLDVRIPPATLWAALGSHRRFLPWRGRPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AV07</accession>
    <name>A0A1H6AV07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52381">
        <property type="protein sequence ID" value="SEG52381"/>
        <property type="gene ID" value="SAMN04489712_10627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="166"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG52381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="446" mass="51011" checksum="43D195F9B7524FBD" modified="2017-01-18" version="1">MGHSRKRTGKDGRPRYTAYYLDIKGQERSAGTFSNKKEADKAWQQAEAEVAKGRHGHAGRGRQTFQEYVEKKWLPNHVMEPQTRQSYTGMINKHVLPEFGPIRMVDIAPEHVRAWVARMQADGASPRLIQYCKGSILNAIFTTAFDDQVIFFHPSRGVKTPTVLKKPRKIVTTAQFDKLYQALPTADAQLLVETAIESGLRWGELTELRVKDLDSETRILTVSRAVVELSPRFHPEGKRFLVKDYPKDGEYRRFKLSRQIVDKLTAHIQSERLAENDLLFAHRQDDHPKTRRPHIALDDSDLGLTEPNEHGRRYRHGTMTAYNLAKCRCAPCKASYATYRANRRATGKDSPRQPRLCDTDGHIPRDWFRRQIWTPARQAAALGFTPRFHDLRHAHASWLLAGGADLQVVKERLGHSTIATTEKYLHTLPDADETALDALSRIRSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AW26</accession>
    <name>A0A1H6AW26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52420">
        <property type="protein sequence ID" value="SEG52420"/>
        <property type="gene ID" value="SAMN04489712_10630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="100"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="313" mass="33328" checksum="81F11461FF8853C4" modified="2017-01-18" version="1">MKPDDDIGRYPGTVHNEGVANFGGSTAIHHSVVGRNATVNMAPQADRSADDRAHSPRWDIGVITIIGVETNAVRVALGLRPERVGGLSFDLGEVDVDGDRPVRVVATRTLAQGQRSTVMAFDHLRRHYDPKIIALVGIGGGINRKVAVGDVVVATRVVYYDLRKELPLHTQRRGEEKEAPAAVGHAANAFFTDHGEPARCTVTDPGGTSRTHQVFGGLIGSGDAVIADHGSEIVSYLAGFNDKILAVDMEAGGLSQACHEQSATSGLLQGWVVIRGISDDAGADKNDDHQAVAAWHAATTLRRMLPYLITLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B1K3</accession>
    <name>A0A1H6B1K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54679">
        <property type="protein sequence ID" value="SEG54679"/>
        <property type="gene ID" value="SAMN04489712_106172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293360" evidence="2">
        <location>
            <begin position="26"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG54679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="341" mass="36270" checksum="4E7AEDA8C11F6AC8" modified="2017-01-18" version="1">MRPSHRIAAVAAAAALAAVPGAAGAEDAAAGEPAPATGNGSWSVGPANRSKALAARPHFAIEAPPGATVKDAVRITNLTGEPITFQLYGADAYNTPRDAGFALRTVDEPRRDVGAWIALKAGTLKVPARTAREVPFTLKVPADATPGEHIGGIVALNTTIESVQESGGARVGVRRAVGARVYLRVTGPLNPGLRPENLTVTRTEPLMPFLRQGRGTIRYSVVNTGNQRITPTARVWATGAFGRRIKQWPDRRLPEILPGQRTEITLPWNGTPPLDAVTVRVELTADGGIRARAQSQFNAVPWAALLTLLGTVFVLWSVLPRLVRRWRERAGLVSDDTEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3K0</accession>
    <name>A0A1H6B3K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55180">
        <property type="protein sequence ID" value="SEG55180"/>
        <property type="gene ID" value="SAMN04489712_106210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="29500" checksum="AB9A77EFCCB4A0A3" modified="2017-01-18" version="1">MADNDVTLVLGGTGKTGRRITQRLKARGVPVRIGSRSAEPPFDWEDPAGWAPALHDVGAAYVSYFPDLAVPQAPAAIEAFTEAAAEAGVRRLVLLSGRGEEMAQQCERIVRHGGAEWTIVRASWFAQNFSEGELLGSVLGGELVVPSGTAPEPYIDAEDIADVAVAALTEDGHAGRLYEVTGPRLLTFTDVVTELSAATGRDIRLTQVPPDEYSDVLKGAGVPAEYVDFLTYLFVTVMDGRNSHLEDGVRQALGRAPRDFTDYARSAAATGVWDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B441</accession>
    <name>A0A1H6B441_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_106243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55598">
        <property type="protein sequence ID" value="SEG55598"/>
        <property type="gene ID" value="SAMN04489712_106243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="14"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG55598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="413" mass="41230" checksum="273C536316ABD5FA" modified="2017-01-18" version="1">MVNVEGGPDGRRWVVLGVGLGAIVAGCVFQFGLPYLLPVLRADGLSLGQAGMLVACPTAGLMVALIAWGAAADRWGERLVLSLGLGVAGLALLAAAAVAGRPLALGACLVAAGAGGASVHAASGRLILGWFGARERGLAMGIRQTAQPLGIGVAALALPPLAVGGLAAPLLASALFCLVMAAAVALFVRDPRRTAQESAQGAGSPYATPVLWRLHAASALLVVPQFTVATFALVFLIDEHGWDAATAGRVLAAVQVGGALARIGAGVWSDRAGSRLRPFRLVAAAIAVVMAALAAGALTGSGVAVAVLLVAGVITVSPNGLAYTAVAEYAGRAWAGRALGTQNTAQNALAMATPPLVGMVVGGPGYGAAFAIAVAFSLAAVPLVPVRGEGRTVTARTDRGRRTRLRRTASPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5P1</accession>
    <name>A0A1H6B5P1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">SAMN04489712_106288</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56148">
        <property type="protein sequence ID" value="SEG56148"/>
        <property type="gene ID" value="SAMN04489712_106288"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG56148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="33067" checksum="77A2205F9851DA12" modified="2017-01-18" version="1">MPGSGRAAGARAAGLLLGVALDAATGDPRRGHPVAAFGRTAAALERRMYADSRARGAVYAGILVTGAAMAGVAVERATRGRCAQVAVTAAATWAVLGGTSLGREGRAMAKALQDGDLEAARARLPHLCARNPAGLGPKELARATVESVAENTSDAVVAPLVWGAVAGVPGLLAYRAINTLDAMVGYRNERYERFGWASARSDDVANWVPARLTALLTVACAPFAGGTMRRSHAVMRRDGAAHPSPNAGRCEAAFAGALGVRLGGTNVYGGRAEHRPELGDGPPPEVDDIRRAVRLSTAVGLAAAAVCAAGALAVRRGAAGTGTRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B784</accession>
    <name>A0A1H6B784_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA G18 (Ribose-2'-O)-methylase SpoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56723">
        <property type="protein sequence ID" value="SEG56723"/>
        <property type="gene ID" value="SAMN04489712_106332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="37"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="29255" checksum="E581448A4A550609" modified="2017-01-18" version="1">MRLVPVEDSADPRLADYVRLRDVQLRKSLEAEHGLFIAEGEKVIRRAVETGYPVRSLLMARRWAEPLADLLQRVDAPVYVADERVLEDVAGFAVHRGALAAMSRKPLPPVPELLGTARRVLVLEDLVDHGNVGAIYRCAAALGVDAVVLSPRCADPLYRRAVKVSMGAVFAIPYARMDDWHHGLGELREVGFRLLALTPDQSAVPIEKAVTGERVALLLGSEGDGLSSRWLKAADEAVCIPMSADAMARGVDSLNVVAAASIACYGLMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BHE6</accession>
    <name>A0A1H6BHE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59815">
        <property type="protein sequence ID" value="SEG59815"/>
        <property type="gene ID" value="SAMN04489712_10792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009467">
        <property type="entry name" value="Glycolipid-bd_prot_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06475">
        <property type="entry name" value="Glycolipid_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG59815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="21430" checksum="02EA5B9D96525845" modified="2017-01-18" version="1">MTRSIVWVKPQGAELAEVAFEGGSLTASGWALGGDPVPYRLEYELATVDGYVTSTLQVRVEGVDPDSGPWRRSIELVNGPDEVWTVRAKAEGHVALPPPGGDAAAVRGALDCDLGLSPLTNTMPVLRSGLLEGGGPVEFLTAWVSVPDLTVTPSRQTYTFVRRDGEHAIVNFAVPGFTEDIVFDRDGLVVDYPGIGRRTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJ11</accession>
    <name>A0A1H6BJ11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60729">
        <property type="protein sequence ID" value="SEG60729"/>
        <property type="gene ID" value="SAMN04489712_107152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG60729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="20385" checksum="9599DBF1F16B996D" modified="2017-01-18" version="1">MTYGTPEQPGYGQQPGYGQPGYGQQPGYGADPGGYGQPSPGYGQPGYGAPEGYGAQPGYGQPGYGQPGYGQVQPYGPHGYGAPATPDERNWAMLTHLGQFVFGLFAPLVVYLIKKDESAFVRFHAAQGLNLAITQSIYTVISLVLMLLLIGFVTIIAVAIAWLVLLVVAAVAANRGEWYRFPSFMAWPMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJA0</accession>
    <name>A0A1H6BJA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ORF">SAMN04489712_107160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60829">
        <property type="protein sequence ID" value="SEG60829"/>
        <property type="gene ID" value="SAMN04489712_107160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="28"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG60829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="629" mass="69147" checksum="B2B78FCF73669191" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJZ4</accession>
    <name>A0A1H6BJZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61010">
        <property type="protein sequence ID" value="SEG61010"/>
        <property type="gene ID" value="SAMN04489712_107176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG61010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="25081" checksum="1A95595FBDB6AA99" modified="2017-01-18" version="1">MSNSHRPHRRRRRRRKSHAGRIGLAGALAGVLGVGAVVAGYVALKPDTEPQTSSNAAVQDGPGPSGGPAEPSDAPRTGPTLSVTTPEGYGYGLGAARTGTAGKPLSRSTAAPSGTAYAYAEYVLTNNQQQPVLLDFPADLFLPLKYVPSAARQRCMPQPGVPKDMCTLPNHSQVIARLNGSAAPIVQDGDALMPPGASYLVRIATDLPVDPRVGEEIRLYVWNARFTSDRRGIEVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BK72</accession>
    <name>A0A1H6BK72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trypsin-like peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61074">
        <property type="protein sequence ID" value="SEG61074"/>
        <property type="gene ID" value="SAMN04489712_107181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293948" evidence="3">
        <location>
            <begin position="25"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG61074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="536" mass="56496" checksum="F24190BC3DDFEF21" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BM64</accession>
    <name>A0A1H6BM64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61286">
        <property type="protein sequence ID" value="SEG61286"/>
        <property type="gene ID" value="SAMN04489712_107200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG61286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="45" mass="5352" checksum="BE257D14D3CCF421" modified="2017-01-18" version="1">MTPTARWAIAQRRKRQVITRTVRDRAIHDPRRREPVLAQVSTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BMT9</accession>
    <name>A0A1H6BMT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, PaaX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62028">
        <property type="protein sequence ID" value="SEG62028"/>
        <property type="gene ID" value="SAMN04489712_107267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="2">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="3">
        <location>
            <begin position="189"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG62028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="38894" checksum="73096C8239C472E0" modified="2017-01-18" version="1">MNDPSVVELEPPSQGADGPSPRLRPQSLMLTFLGNYVLRRDIAVSSASFIEIFARLGVGEHAIRSTLSRMVARDLLARHRRGRRMHFGLTERSARILQDGENRVWRRSVVNDDWDGRWTLLAFSMPESWQSRRHDLRSALTWAGFGSMGNGIWIAPSRVEMGPTIAGLGLSDHVKVFTSVAEEPTDVAAMIRDAFDLAALASAHQAFLDRWDRPDPIPHAPDDLARYLWMTTEWLQLVRMDPRLPVEHLPPDWPAVRGQRLLRELRARYEEPARRLADAAIEFIEVPVGPSAALPADAEPDDAGPDDAGLDDAESDDVEPDDPSVGVEPDEAPGHVQVRLDAGGRVPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BMY0</accession>
    <name>A0A1H6BMY0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="10" type="ORF">SAMN04489712_107246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61805">
        <property type="protein sequence ID" value="SEG61805"/>
        <property type="gene ID" value="SAMN04489712_107246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="108"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG61805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="354" mass="38109" checksum="CF697EF4D29DF546" modified="2017-01-18" version="1">MAALRSLESEKDISLDLVVKAIEDAMLIAYHRTEGAAPKARVELDRRSGHVTVWAAEIDEEGNTLREYDDTPEGFSRIAATTAKQVILQKLRDAEDELTFGEYAGREGDIVSGVIQQGKDPRNVLVDLGRIEAVLPPQEQVPGESYEHGDRLRAYVVQVRKGHRGPSVQLSRTHPNLVRKLFALEVPEIADGTVEIAAIAREAGHRTKIAVRSRKAGVNAKGACIGPMGSRVRNVMHELHGEKIDIIDWSEDPAEFVGNALSPARVSGVQVVDEGGRVARVIVPDYQLSLAIGKEGQNARLAARLTGWRIDIRPDTEQPAPPGPGQATGTGRAGSDTSGSSTEHATGPADASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNK7</accession>
    <name>A0A1H6BNK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cellulose synthase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_107285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62271">
        <property type="protein sequence ID" value="SEG62271"/>
        <property type="gene ID" value="SAMN04489712_107285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293914" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="4">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="663"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="794"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG62271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1114" mass="120398" checksum="6BC8E3DDB2F914BE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNL0</accession>
    <name>A0A1H6BNL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, OmpR family, contains REC and winged-helix (WHTH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_107287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62299">
        <property type="protein sequence ID" value="SEG62299"/>
        <property type="gene ID" value="SAMN04489712_107287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="139"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="139"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG62299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="27174" checksum="36A22A0E1A6A5BD1" modified="2017-01-18" version="1">MSQAEAHIVVYGADMATVLVVEDDPNVRAALIRELGARSHTVRSAGTAMDMLREIARNPPDLVVLDLGLPDLDGAEALKMLRGVSDVPVIIATARDDETEIVRLLNAGADDYLVKPFTAEHLGARLSALLRRAGRAGPVMRLAVGGLHIDVDRREAALDGRPLELTRREFDLLAYLAARPGRVVSRRELLAEVWHQAYGDDQTIDVHLSWLRRKLGETAASPRYLHTVRGVGVRLAAPAAPEPETAPDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPZ4</accession>
    <name>A0A1H6BPZ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ORF">SAMN04489712_107322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62789">
        <property type="protein sequence ID" value="SEG62789"/>
        <property type="gene ID" value="SAMN04489712_107322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG62789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14754" checksum="58CBAE7F90326DA8" modified="2017-01-18" version="1">MSERTLVLVKPDGVRRGVVGEVISRIERKGLNIVALELRTLSRETAEDHYAEHRERPFFGELVDFITGGPLVAMVVEGPRAIEAFRALAGATDPVKAAPGTIRGDHALEIGENIVHGSDSPESAAREVKLFFPELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BVK5</accession>
    <name>A0A1H6BVK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64662">
        <property type="protein sequence ID" value="SEG64662"/>
        <property type="gene ID" value="SAMN04489712_10844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="32"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24095" checksum="7B78E2B58F887F33" modified="2017-01-18" version="1">MSYTGDVQVGGRADVRELPGLTIAKVAVGPYDNNAYLLRCTATGEQLLVDAANEPERLLELVGDGPLDRIVTTHRHQDHWQALSAVVRATGAAVVAHPFDAESLPEPVAERVEHGDRVRVGEAELEVVHLRGHTPGSIALLYDAGGELADRPHLFTGDSLFPGGVGNTWGDPALFKQLLADVEERVFDRLPDATWFYPGHGKDSTLGRERPSLPEWRARGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1R3</accession>
    <name>A0A1H6C1R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-glucoside transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_108235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66904">
        <property type="protein sequence ID" value="SEG66904"/>
        <property type="gene ID" value="SAMN04489712_108235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="126"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG66904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="489" mass="51294" checksum="9270F95E6C784A90" modified="2017-01-18" version="1">MTDTSEPPAPREDRPADEPAGGGTSPPAAGPVADRAASVATTPAEAPAEAASGGRSAKAAGRERLGPPPWLAGGFLAPALVLLALLVVYPIVYTLWRSLYDADGGRLVWFDNYVTMFTDSTTFTAIKNNAIWVAVAPALITAFGLIFAVLTERIRWAAAFKVIVFMPMAISMVAAGVIFTLVYDHSPERGVLNAVAVGVHDTFAAASPYPGVRPREQGSPLKPEGKAFVTTAQVQPGQAVTLPLVAVPPAKQRELAPARAAAPAQGAITGTVWADFAPGGGKVNQIDGNEKGLPKVEIEALAGGKVAATTTSRDDGTFTLDGLAPGSYTLRLAESNFAAPYNGVTWLGPGLVTPAIIGAYVWMWAGFAMVLIGAGLAAIPRDALEAARVDGATEWQVFRRVTIPLLAPVLMVVFVTLVINVLKIFDLVYIMAPGSSVQDANVLALRMYLVSFIGERPDQGLGSAIAVVLFLLVLPAMIFNIRRFRAEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIL9</accession>
    <name>A0A1H6CIL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72758">
        <property type="protein sequence ID" value="SEG72758"/>
        <property type="gene ID" value="SAMN04489712_11032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG72758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="112" mass="11763" checksum="971AD53F6FB8BFB4" modified="2017-01-18" version="1">MEATAVMVALADVPRAESRPPSAPALDAAHTLAPDEGRPDGDLPAALRDRCAAVIDAEVTRLARRTALDCAQLAIVTGALHRLADSLLLERVRAGHCEPSLLAALFDLETTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJW3</accession>
    <name>A0A1H6CJW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73254">
        <property type="protein sequence ID" value="SEG73254"/>
        <property type="gene ID" value="SAMN04489712_11088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="32949" checksum="1D0F7DCC1D236B98" modified="2017-01-18" version="1">MRDPELVSCAQRAASELERAWSQWRHSRGLAGPAPESVTGYVTHSIDHPWGRPRVVLGLDADEAHALAALLGGRNAAPALVDAPPSREDSLPGRELDRKDTPSVREIPPPGREDAPLGRESTPLNRTDAPLRQGNTPLDRTDAPLARENATLGQEDALLGRENAAFGRKEAAFSQDNSPFNRRDEQVSQDTSPLSRREAVLGQEGSPFNRRAEQAGHEGSPFSPRDAGLGQDTSPFSRRDEQAGQEGPPFSPRDAELGQDTSPFGWGDEQFGQEDGPLGREEASPDPRGGSRGQGGAALGREDVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQL2</accession>
    <name>A0A1H6CQL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75291">
        <property type="protein sequence ID" value="SEG75291"/>
        <property type="gene ID" value="SAMN04489712_11112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="94"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG75291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="29777" checksum="621133AACBB33DAF" modified="2017-01-18" version="1">MWDTDDLVNASGLGGTMGARGTADGDRSRYHIAALAKGLQVLSLFDGTTLSLRTSDIAARTGIPMPTTFRIVSTLEELGYLERTHDGALQPGVKVLTLGSAAMRGSGLVQLSDRPLRLLAEATGETVNLGVLVEDRVLYLARLRNADLVTANVHVGSTLPAPYTSMGKLLLAYLPPDEFDRRITAASFTPGAGPNAVSSVPELRDRLEQIRRDGYAIQDQELAQGLRSVSVPVFGADDLPVAAVNVAVSTARHPESALHGTILERLRGTAADISAKLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRI8</accession>
    <name>A0A1H6CRI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family with amidase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75622">
        <property type="protein sequence ID" value="SEG75622"/>
        <property type="gene ID" value="SAMN04489712_11164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="233"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="36335" checksum="EC2DB5D488460A5F" modified="2017-01-18" version="1">MAASLRPAGRSAVPPPVRPHVVAVLAFDGMSPFELGSVAEIFGLPRPELRVPWYELRVCAERPDRMMRSFGGLALTAGHGLEEFAAADTVVVVAVPDVRAEVPPALVGALRTAHGRGARVVSICSGAFALAAAGLLDGRTATTHWRYAELLQRRYPRVRVDPDVLYVDDGDVLTSAGSAAGLDLCLHLIRRDHGARVANAVARRLVVPPHREGGQAQFVEAAVAEPARDDAVARSMAWALDHLAEPITVADLARRAHLAPRTFLRHFGRQTGTSPLRWVVVQRVMASLPLLEAGSMPVEEVGAAVGFGSPATFRHHFTRIMKTSPSAYRRTFRDTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTK3</accession>
    <name>A0A1H6CTK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76282">
        <property type="protein sequence ID" value="SEG76282"/>
        <property type="gene ID" value="SAMN04489712_111145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG76282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7535" checksum="F38087998691952C" modified="2017-01-18" version="1">MPIPEQAFERALDIQELMVQRGTHRSAGLADLLLAAAAEEHRLTVLHDDKDFDCIAAVTGQPVRRVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1S1</accession>
    <name>A0A1H6D1S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_112120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78745">
        <property type="protein sequence ID" value="SEG78745"/>
        <property type="gene ID" value="SAMN04489712_112120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="92"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG78745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="314" mass="33582" checksum="C98E906571135292" modified="2017-01-18" version="1">MVTSVRRREALREATAWVRRTGETGRAAASARRVPWIFVAPAAALCSAVLLIPSLLGAFYAFTEWDGLTAPKWVGLGNFAEFFTRPEGTGVLAHTLVIVVCYVVGVNAVGLGLALGLERALRTRNVLRTLFFVPAVVSPLVVAYVWKFILDTHGPLNTALEALGLGAVAQPWLAKPETALPAIIGVMVWQFSGYHMLIYLAGLQGIQAETREAAMVDGAGSWLLFRHIILPQLRPAITIGVALSTIISFTLFDQVMALTGGGPSGKTETLGTYVYKQAFVNGQYGYSAAVALLLVGVVCVAAAGQLRALRREDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3C6</accession>
    <name>A0A1H6D3C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79303">
        <property type="protein sequence ID" value="SEG79303"/>
        <property type="gene ID" value="SAMN04489712_112196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010814">
        <property type="entry name" value="DUF1416"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07210">
        <property type="entry name" value="DUF1416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="10382" checksum="71E109EFBFB56091" modified="2017-01-18" version="1">MTQGCAAPAQTAHLPATVDLANEAVIQGTVTRDGAPVSSAYARLLDSSGEFTAEVVTGEEGVFRFFAADGDWTVRVLAAGGVSVDNTVTAKVGEVANLEVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4C0</accession>
    <name>A0A1H6D4C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80187">
        <property type="protein sequence ID" value="SEG80187"/>
        <property type="gene ID" value="SAMN04489712_11335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="12286" checksum="A1B96B26BF6C0FA3" modified="2017-01-18" version="1">MKLRDPGKIKEALNDLDFPAAKEEIVRHARSRGARRDVDQALSALPPADYANIREVLRSVPLDPDPDLSESERAERHRQAKHKNRLSEHEIPIRPSPVEEELRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D676</accession>
    <name>A0A1H6D676_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80245">
        <property type="protein sequence ID" value="SEG80245"/>
        <property type="gene ID" value="SAMN04489712_11348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG80245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="338" mass="34647" checksum="37F6699CA06DC363" modified="2017-01-18" version="1">MAEGRTAGGLDLGRFLRWDVVVAALLIVVFFGGAGLSPDFGNTDNLSFALGDLGEIALIALPMTLLVVCGQVDLSVASVLGLASALTGALWDAGWAFETIVPVVVLAGVVCGLINGLLVTRLGLPSLAVTIGTLSLYRGLAYVLLGTEAIAEFPQQYADLATTNVPGTPVPYPVALFVLLAIVTALVLHATGIGRSLFAIGAQEDAAFYAGIRVKRIKLVLFAVSGVVAAFAGIVYTLRYGSARADNGVGLELAVIAAVLLGGVDFDGGKGTLGGVIAGVLLIGLLRNLLMLNDVATEIQSIVTGLLLIVSVLTPRLITAAGQARARRRHRDPAAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7M8</accession>
    <name>A0A1H6D7M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81291">
        <property type="protein sequence ID" value="SEG81291"/>
        <property type="gene ID" value="SAMN04489712_11418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="PTHR21198:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="240" mass="25835" checksum="8AFEE354B61FF365" modified="2017-01-18" version="1">MKHLGVLAHSTGGAALCFLTFCEEGFRRTGRNEHPDVTLDYIAFGYSMPAWDAGDHATVRATLATSAQRLARAGADFFVCPDNTAHMAMEVPGPDLALPGLHIAEVVADQAAAEGRTRVGVLGTRYTMDGPLYPRAFAARGIAAELPDADDRDLVNEVIFKELVNGVISDASRREYLRVIDRLADRGCDAVALVCTEIPLLITPEVSSLPTLDSTRLLARAAYDVAVGERAMPDWRGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9B2</accession>
    <name>A0A1H6D9B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81235">
        <property type="protein sequence ID" value="SEG81235"/>
        <property type="gene ID" value="SAMN04489712_1144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="168" mass="19893" checksum="22579460B3863156" modified="2017-01-18" version="1">MPEELDTASTLKQLEKRVEELEAVRDITRLRAEFHRSLNNREWDTLAGLFTDDAHLDYGEYGQAHGSREVRDYYGQLLEQIRDMRNATAILLKNFIHGHQVHLQGENTATGVCFFEEQIRFNQDSHAFSSIGQFSDKYVRIGDRWYFAKVELDHYWVVPDNDGWRWPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9I7</accession>
    <name>A0A1H6D9I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81842">
        <property type="protein sequence ID" value="SEG81842"/>
        <property type="gene ID" value="SAMN04489712_114156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="25951" checksum="5D409FF9C7A10083" modified="2017-01-18" version="1">MQFTSEQRLDDGVLEREFALGEIPGILWTPASASAPAPLVLIGHPGGLRKMYPRLVGRARHSAADGFAAATIELPGSGDRPSSVATEQARADLRRALEAGEPVDEEIVDRLVLPLVEKAVPEWQAALDALLSLPEIGGPVGYSGGVISIGIRLAVVEPRISAAVLFAGSFVPRALFEEARQVTIPLHVLLQWDDEGNDRQLALDLFDAFGSKEKTLHANLGGHTGVPQFAGDAAAQFFTRHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEE9</accession>
    <name>A0A1H6DEE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83807">
        <property type="protein sequence ID" value="SEG83807"/>
        <property type="gene ID" value="SAMN04489712_11671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG83807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="42933" checksum="237C166C14F4606B" modified="2017-01-18" version="1">MDFSLTEDQQSIRDAVLDHCSRFSDEYWLERDREGVFPHDFHKTMADSGWLGVAMPEAVGGAGLGITEAAIMMQAVAESGGGMTAASSIHGPVFSMQPVVLFGTEEQRRRMIPSVLDGEHLLCFAVTEPDAGLDTTRLRTRAERRDGGYLVNGEKIWISVAQVADKMMLLARTTPLEEVERRTEGLSLFFTDLDRSRIEVRRIAKMGRHAVDSNILFISDLWIPEQDRIGAEGEGFKIILHGLNPERILLGAEAVGLGRAAIRRAARYARERVVFGRPIGMNQGLQHPLAKCWAQLEAANLMVMKAATMFDQGLDCGVEANAGKYLAAEAGFEACHTAMLTLGGMGYAQEYHVERYLREVLIPRTAPVSPHMILNFLAEKVLDLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEP6</accession>
    <name>A0A1H6DEP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain-containing protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_115163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83175">
        <property type="protein sequence ID" value="SEG83175"/>
        <property type="gene ID" value="SAMN04489712_115163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="65" mass="7232" checksum="A6CEDEAEBD3488EC" modified="2017-01-18" version="1">MRGGHLAEAKLLTVPEVMAALRLGRWKVYDLIRSGELESVTVGRARRVPADALDRFISQLREDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF28</accession>
    <name>A0A1H6DF28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83820">
        <property type="protein sequence ID" value="SEG83820"/>
        <property type="gene ID" value="SAMN04489712_11674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="27736" checksum="1603D14AD46CD81E" modified="2017-01-18" version="1">MSDAVLFAARDDGIAVITLNRPETRNCLTREVREGLYAAWDRFERDPALRVAVLTGAGEKAFCAGGDLKEMVETGMRVPPRDMFPLPYDTVELSKPTIAAVNGVAFAGGWMLAQACDLCVASTGATFAVTEVKVGRSSPWAAPLIHMIPQRIMMEILLTGRPITARRAYEIGLVNRLADPGELLETALELAGEILDGAPLSVRAARETVMLSTEMGRSAALQAARHASERCYHSEDAQEGPRAFAEKRPPRWKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFU4</accession>
    <name>A0A1H6DFU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_116112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83962">
        <property type="protein sequence ID" value="SEG83962"/>
        <property type="gene ID" value="SAMN04489712_116112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295935" evidence="2">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="21338" checksum="FF9B4013CDFA5A1B" modified="2017-01-18" version="1">MLTTPRPLVALMVAGSVVAGAGAAAIRLLNDANGLTDAGRRPAFGTDGARRGVLRSPAVPVALSAPSIMLRAAVVPVGVDETGAMALPDDVSYVGWYQYGPRPGSAGGSAVLAGHVDSRERGTGPLASLHRVSPGDRLTVRLADGREVGYRVVSREVIERSAMPLNVFFARDGLPRLTVITCGGPFDAALGHYRDNIVITAVPVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHF7</accession>
    <name>A0A1H6DHF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84641">
        <property type="protein sequence ID" value="SEG84641"/>
        <property type="gene ID" value="SAMN04489712_11740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="40204" checksum="7F52E52AB0C3DB8F" modified="2017-01-18" version="1">MDERVVKAEPAGGRRAEPASPDAFGEIAGEMAGEVARRVGAAADPVRQAAQQAASEAATQIVERLAGTPAMRAVEQAAREAAVKAATRAARKAADDVRAAAAGHPVAGTALEATSAAVTLAGRTAAHPLAATALRLAARHPLSQAAAEAARDLASRTAASPAVQAAVRQVTDTVLEPVLDTVTDVAVDLAVDVALEAGRDVVMDVLAATARRAARDLAGDLAGLARDRTREAVRATGAAPLAAAVADLAAGLAVDVAADLTGRSGPETVEAAREAATAAVASTRHAAVAAVAALAENPMARSAQQLLVHTAGRAMASAVEAVLWELIREPLKAALKVVLREVIWDAARQVVADAVRTALTAGREPGPGGPAGPVVITMVPEPDRESGGQPGGGPGGESGAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIK5</accession>
    <name>A0A1H6DIK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84515">
        <property type="protein sequence ID" value="SEG84515"/>
        <property type="gene ID" value="SAMN04489712_11717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045686">
        <property type="entry name" value="DUF6189"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19688">
        <property type="entry name" value="DUF6189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG84515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16896" checksum="17184B3C2408CC93" modified="2017-01-18" version="1">MAVWKDARWLARLAGEQLKGRRRYDIAGTPTQAENQELAEVMRRLPERYADRLTPRTLQGISGAAAAGQWEQAVDRLLAALRARSAPVTAGERDELHMVLAALRMPADRVDALVPPTDATSRDGRRNEDLDLTASWRADGAAWRVWRARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJK9</accession>
    <name>A0A1H6DJK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85587">
        <property type="protein sequence ID" value="SEG85587"/>
        <property type="gene ID" value="SAMN04489712_11839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG85587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="30030" checksum="2FFED8CF89B2A081" modified="2017-01-18" version="1">MNRYGPRTLLREIIMIAVAAVVAFPLYVLVNLSLRDPRDGSSVIAPTTSPTLRNYADAWREAGLAGAIVNSVVVTVLSVAVIVIVSAMAAYPLARITARWSRWAFLLVMLGLLLPFQLALLPLYQTIRDLGLLGTLWSLVLFYSGLQVPFATFLYVGFLRAVPREYEEAALIDGAGPVQVFWRVVFPLLRPVTGTVVILNAILVWNDFLTPFLYLSGSDQQTIPVAIYGFIGQFVSQWNLVFAGLVIAMLPILVGYFLMQRHIIKGFAGGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DK01</accession>
    <name>A0A1H6DK01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase, alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_117106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84986">
        <property type="protein sequence ID" value="SEG84986"/>
        <property type="gene ID" value="SAMN04489712_117106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="33768" checksum="518CC7891316A316" modified="2017-01-18" version="1">MTVPTEPRPGHRVVDVGGVPMSALVGEVPRPRAVVVALHGGATTSVYYDAPNRPRLSLLRTGAALGFTVIALDRPGYGGSEAYADRLTDPRRRVDLAYGAVDRLLEARPRGAGVFVMAHSVGCALAVRMAADERGADLLGLEIAGTGLHRQPRADEILLARHQDLLDGLEGRGRRRPATAGAPGAAGGGLRDLIWGPRHLYPADVAGISSATPGYEGVEVEHWRQTLPDLAARIRVPVHYSLGDHETVWRCGPVGLAEVAALFTTSPRVVVHEQVNSGHNLSVGLSARAYHLKVLSFVEECALAREAAPLPSHRQGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DK78</accession>
    <name>A0A1H6DK78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85678">
        <property type="protein sequence ID" value="SEG85678"/>
        <property type="gene ID" value="SAMN04489712_11858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="792"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG85678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="990" mass="104281" checksum="BFBC19605D4B1265" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLV8</accession>
    <name>A0A1H6DLV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86407">
        <property type="protein sequence ID" value="SEG86407"/>
        <property type="gene ID" value="SAMN04489712_11975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="23"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="27392" checksum="9362CC3A4049B62D" modified="2017-01-18" version="1">MPVSSGSWLRRFDPRPQAALRLICLPHGGGGASFFAGWAGALPAWAELVAVQYPGREDRFGDPFPGDLHDLVRGLADDVEPLTGRPYALFGHSMGATVAYELAHELLGRGRPAPVHLLVSGREAPHDERGGRVHLLDDDGLAAELARLGGTAPEVLRDAGLRSVILRYVREDYGLIETYRPRRRPPLACPVTVLLGDRDPDLTVAEAGRWRWATHGPAEVRVFPGDHFYLVPQRDAVLATLRRVLDGSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLY9</accession>
    <name>A0A1H6DLY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NitT/TauT family transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86218">
        <property type="protein sequence ID" value="SEG86218"/>
        <property type="gene ID" value="SAMN04489712_11923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG86218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="277" mass="31007" checksum="E48641C5D7CF42F0" modified="2017-01-18" version="1">MTEAVRSGLPPTGDVAPIADKIRIEGLSYRYRRRGREDVVALDDVDLTVGRGEFLSVAGPSGCGKSTLLRVLAGLQKPTAGVVRINRERRGRPLVAPVFQEYSIFPWRSVEANVRLGLDAAGVDRSEARRRSQEWIERVGLAGFEKALPGNLSGGMKQRVALARAFVVEPEILLMDEPFAALDAQLRKVLQEELLAIVREHTYTVFFVTHNLDEAILLSDRIALMSARPGRMRRIVDVPFARPRSAELRKDPEFVRLEEELWADLKGDVETIEEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNX9</accession>
    <name>A0A1H6DNX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86891">
        <property type="protein sequence ID" value="SEG86891"/>
        <property type="gene ID" value="SAMN04489712_12028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="18212" checksum="59646BC7A84974DD" modified="2017-01-18" version="1">MIDGTSVPGTGELGLLLGFLNAQRSAVAAKCDGLGEETAHRPLLPTSPLMTVAGLVSHLRWVEQSWFEHILLGEPELGPWTDEDPDREFRVDGVPLPRLLADYRRQCARSDEIVTSVGLDAAAAVERHGAHPTARWIVLHMIEETARHAGHLDIVRELLDGRTGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQ20</accession>
    <name>A0A1H6DQ20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87234">
        <property type="protein sequence ID" value="SEG87234"/>
        <property type="gene ID" value="SAMN04489712_12094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="281" mass="30154" checksum="D6036FFA071513D6" modified="2017-01-18" version="1">METARIVLGVVTAALLPHCLPFTRKSLVASLGISVAYGTWILATILWTWQAAVIFALLLGWSFYVWSASAAGRAGRPPGGPPPVSYRGPLRRARHRFVSLFPSADGEFSQANARVRTLLGSPGGRRFAVLTVCALVTVVAMAFLVDAGGTARFFHRLDEDHALAIVVSGLLAAVLVSHAPVTFFSTRFGGTRPAESIDYFNLSDPSIYIGWFERALIFSFIVAGQAEAAAMALAAKSIARYPAIEHNPEFGRYFIVGTFSSVLAGILWAVIVRLALGLSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRD5</accession>
    <name>A0A1H6DRD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87937">
        <property type="protein sequence ID" value="SEG87937"/>
        <property type="gene ID" value="SAMN04489712_12140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="32166" checksum="39A83B56097EF190" modified="2017-01-18" version="1">MKIAFLGDVHGCVLHALGAAVMLQARRGIRLDAVIQVGDLGAYPSPERLDESSRRFGRGHPAQGDFMRLLDPPPPFAAGVRLALGQIPPVLFVSGNHEDHPWLAALHDAAAGEVAPVDPLGAYRHVACGNVVETAGQRVAFLGLIEAPGKMDLDEGAYARLMAAEPGSVDILVTHDGPYGMSRDRNGKEQGSPKLTRLIEHLRPRLHVSGHYHHPNGPRRYGPTTSYALALLVQPKVTRWDPEPINPRQQVAAGSVGLFDTGTGAFEYVRDEWLADVRGDALDLAALVRSCAGHGLAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSV0</accession>
    <name>A0A1H6DSV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monosaccharide ABC transporter ATP-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87813">
        <property type="protein sequence ID" value="SEG87813"/>
        <property type="gene ID" value="SAMN04489712_1217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="251"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG87813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="503" mass="53717" checksum="51A11EA4794FD769" modified="2017-01-18" version="1">MDLDLEERQVAPVLELREVRKAFGGAQALAGVDFTLLPGEVHAVVGMNGAGKSTLVEMICGSFAPDSGDILIDGERQASLTPRRAHAAGVSIVHQKRTLVDGLTVAENLLLGRLPTRAGRVLWKRVRQEAARALDGLGIDIAPDAVAGALGPAEQTLVEIAREVDLGGRVLVLDEPTASLGGRDAQRIHRLVRTLRDRGTAIVYISHHLDEVLDLADRITVMRDGRVATVVRSAELDLPALIRAMVGDRLVHERSGTSRSPGKPVLELAGLSGGRLHAFDLTVRAGEVVAVLGPAGDGQCELFRLLTGLRRAESGRVTVNDAEVAPGNVGASLAAGLRCITGDRLSYGLVPALSVNENLDLVRRGRRRPWLVRWRDIHAQGRQARQRYGVTTLQVDPPVSTLSGGNQQKVLLSAWLDGDPVACLLEEPTNGVDVAAKADIHRIVDDLADRGAAVLLSSSDVDEVVRLADRVVVVRSGRIVADLPMDRVTRDDLVTLTAGGEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTI0</accession>
    <name>A0A1H6DTI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88578">
        <property type="protein sequence ID" value="SEG88578"/>
        <property type="gene ID" value="SAMN04489712_12235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="408"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="501" mass="53200" checksum="7245D714C0BF1E74" modified="2017-01-18" version="1">MNVTMLLDMAAEGFGDRVVVGRRQDGLTAVRLRELSIGGARAVAAAGADSILYLGVNGPAFPVAMFAAARAGVPLVPVNYRLGREQLGRLLAGHPGAYAIADEGQLEMLGAAGLAARTPEEFMAAAADGDLGEPGEPGWTDAPAVLIYTSGTTSAPKGVVLRHQNLVSYVLGSVEFAAAGEEEAALMSVPPYHIAAVSNVLTNLYAGRRFIALPSFSPAGWLEVVREQAVTNAMVVPTMLARIMDADGLDRSVPSLRTLAYGGAKMPPRVIERALAEWPHVDFVNAYGLTETSSTISVLGPEDHRTAFASTDPEVRARLYSAGRTVPAIELEVRDEEGRVLPAGESGRIWVRGEQVSGEYAGQGSAVDERGFFDTRDRGRLDAGGYLFVEGRIDDTIIRGAENIAPAEIEDVLLRHPDVADAVVVGVPDEEWGQRIEAVIVPAPGAGVDTEALREHVRSLLRGSKTPDRIVVWPELPRTPTGKILRHDVVTGLTAGRQTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTZ7</accession>
    <name>A0A1H6DTZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88827">
        <property type="protein sequence ID" value="SEG88827"/>
        <property type="gene ID" value="SAMN04489712_12288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="818" mass="87603" checksum="DC95E9433DC7A9F2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVW1</accession>
    <name>A0A1H6DVW1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">SAMN04489712_123100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89470">
        <property type="protein sequence ID" value="SEG89470"/>
        <property type="gene ID" value="SAMN04489712_123100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG89470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="43430" checksum="3F0004AB8411BF73" modified="2017-01-18" version="1">MSERIVLAYSGGLDTSVAIPFLAEQTGAEIIAVAVDVGQGGEDLEVIRKRALACGAAEAVVVDAREEFAADFCVPALQANALYMDRYPLLSSLSRPLIVKHLVAAAKEFGGTAVSHGCTGKGNDQVRFEAGLSALHPDLKVIAPARDFAWTRDKAIEYAESKGLPIDVSAKSPYSIDQNLWGRAVETGFLEDIWNGPIEDVYDYTADPAVPRDPDEVVITFTAGVPTALDGRALTPYQIITELNQRAGAQGVGRIDMVEDRLVGIKSREVYEAPAAIALITAHMELENVTVERDLARFKRGVDQRWGELVYDGLWFSPLKYALDAFIADSQRQVSGDIRLTLHGGRAVVTGRRSDASLYSYDLATYDTGDTFDQSLAKGFVELFGLPSKMAAIRDRRVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX91</accession>
    <name>A0A1H6DX91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trypsin-like peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89819">
        <property type="protein sequence ID" value="SEG89819"/>
        <property type="gene ID" value="SAMN04489712_12477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296315" evidence="3">
        <location>
            <begin position="25"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG89819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="547" mass="57229" checksum="FEBF91EDEA2FDF73" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY11</accession>
    <name>A0A1H6DY11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90222">
        <property type="protein sequence ID" value="SEG90222"/>
        <property type="gene ID" value="SAMN04489712_12573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296356" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="47" mass="4888" checksum="6044C5923547C872" modified="2017-01-18" version="1">MFPQPKKYGQMIAGLVAAIYVFNNPAQAAEFVNKAVAAISTFAGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0F6</accession>
    <name>A0A1H6E0F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90684">
        <property type="protein sequence ID" value="SEG90684"/>
        <property type="gene ID" value="SAMN04489712_1278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="17135" checksum="35090095FF81124F" modified="2017-01-18" version="1">MSDLRDIPDPLALESQVCFALAVASRSVLAVYRPLLEPMGLTHPQYLVMLALWQHHQVSVKELSGLLQLDAGTLSPLLKRLEAAGLVRRERDSRDERMLCVTLTAAGRDLRAQAEKIPAAILDRLGMELGELQALHQSLTRLITAAHQAASTDPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0V5</accession>
    <name>A0A1H6E0V5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-phosphofructokinase</fullName>
            <ecNumber evidence="3">2.7.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fructose 1-phosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_12869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14213"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.56"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.56" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91238">
        <property type="protein sequence ID" value="SEG91238"/>
        <property type="gene ID" value="SAMN04489712_12869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008662">
        <property type="term" value="F:1-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022463">
        <property type="entry name" value="1-PFruKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03828">
        <property type="entry name" value="pfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="9">
        <location>
            <begin position="8"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG91238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="312" mass="31970" checksum="06DBBDB9FC0B695A" modified="2017-01-18" version="1">MIVTVTLNPSLDRTIEVDELTRGAVIRTRSARLDPGGKGVNVSRALLANRVACGTVITAGGPDGDRLQRLLEAGGLRVRAVPVAGHTRSNITIVEPGGVVTKLNEPGAALTRPELDAVAEAVLTEAETAGWVVACGSLPPGVPDGIYAELCRTFVPAGIRVAVDSSGPALPAAVEAGPDLVKPNREELAEAVGRRAERLGDVVEAAQELRKRGARAVLVSLGADGAVLVDDDGVVAGEAPVTRPKSTVGAGDALLAGFLAGGARGPRALAEGLAWGAAAVRLPASRMPGPADIRHDIVHVYEHPDLNRPLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E114</accession>
    <name>A0A1H6E114_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5941 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90864">
        <property type="protein sequence ID" value="SEG90864"/>
        <property type="gene ID" value="SAMN04489712_12761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045985">
        <property type="entry name" value="DUF5941"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19365">
        <property type="entry name" value="DUF5941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5941" evidence="2">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23387" checksum="B32BA8C7A3EFDF68" modified="2017-01-18" version="1">MTITLTEAPPAAPVARQIGRLQAYRDDGPICTTIGRLTLGRLIPLPGTVVAALTTAALLLVAGAQEHAIPVLYAPLVALLLTGPSATHPHTGRIDWLVPPILRGIEYGYLAVLGFAQGVSAPLIYGLLAVLAYHHYDTVYRTRQHLWPRGWVFRAGLGWEGRMLIAAFAGLFGQLSAAYAVLAAYLGVLFGVESVIAWVRADRGSGVQVNLEEEAEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E344</accession>
    <name>A0A1H6E344_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 9">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_13147</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 9"/>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91967">
        <property type="protein sequence ID" value="SEG91967"/>
        <property type="gene ID" value="SAMN04489712_13147"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="10">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG91967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="750" mass="82483" checksum="BDEDEB06F2B18FC4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E355</accession>
    <name>A0A1H6E355_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mycothiol maleylpyruvate isomerase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92050">
        <property type="protein sequence ID" value="SEG92050"/>
        <property type="gene ID" value="SAMN04489712_1324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="23061" checksum="6CD784B44013DC37" modified="2017-01-18" version="1">MTADDLDLAVQLTVAALRETPPEAWERTAGSLEWDCWETVEHLIDDLFSYAVRLGPRTPPLDGRVPFARERRRPGGPANSVHVDRTADPAGLLQALEASGALLVAMVRTTPPQTRAYHVYGVSDPEGFAAMGIVESLVHTHDLAEGLGLTWDPPADLCSRALARLFPDAPQTTDPWPTLLWATGRAELPGHPRRTTWRWNGIPHSERTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3V9</accession>
    <name>A0A1H6E3V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92388">
        <property type="protein sequence ID" value="SEG92388"/>
        <property type="gene ID" value="SAMN04489712_13337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="168" mass="18863" checksum="4BE54278DC9C1F9B" modified="2017-01-18" version="1">MNTPQHAPRPESSPGPGTTPELAEELRISVARLSRRLRSVSAGAPAGTRPDGSPQPARLTMSQHAVLAVLERHRSMTPRELADHERVQPPSMTRVIAALEEQGLVERSPHPTDGRQVVLRVTERGTRLLEEERRRKEAWLSQRLRELTPQEREILHQAAPILDRLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3W1</accession>
    <name>A0A1H6E3W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91734">
        <property type="protein sequence ID" value="SEG91734"/>
        <property type="gene ID" value="SAMN04489712_13035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="113" mass="12733" checksum="B187383FE7C8103C" modified="2017-01-18" version="1">MARRLKREGIYVFHNFIAQIWREHDLKPHRQGTFKLSTDPDFAEKVIDVVGLYLAPPVGAVVLSVDEKTQIQALDRIQPVLPISFGSTEQRTHNYVRHGTTNLFAALDVAGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4D7</accession>
    <name>A0A1H6E4D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92608">
        <property type="protein sequence ID" value="SEG92608"/>
        <property type="gene ID" value="SAMN04489712_13447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="166"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="30195" checksum="530CDA92F54A4630" modified="2017-01-18" version="1">MTGSVPDSTRGILRATTALRRFRMHRLAPSSELAPYAEYHWILRWDLRGQPPHSQQVLTHPSVHMTFTTGGRARVVGIVRGVFTETISGHGRVVGVRFLPGGFRPFLDGPVSALTGRYVPVEEIFGPQARVVADKVIAAPEEAEAIALMEDLLLARVPERPDPAVAEVAAIVGRIAADPTISRVDRLAADLGVGTRSLQRRFAEYVGVGPKWVIGRYRMQEAAERAAAGDGVDWAALAAELGYADQAHFVRDFTATVGTPPARYARDCATGAPGEAGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4R6</accession>
    <name>A0A1H6E4R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91986">
        <property type="protein sequence ID" value="SEG91986"/>
        <property type="gene ID" value="SAMN04489712_13158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="91" mass="10205" checksum="ED319EC06FAD3E84" modified="2017-01-18" version="1">MSDEVIEAVLQSWVAELERCMRGSRAELCGPSRRSGRWAYVSGPVAGLERKNGWMQAEHAGVASPDGMQRLLRRADWDIDGARDDLRDYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4Y6</accession>
    <name>A0A1H6E4Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91945">
        <property type="protein sequence ID" value="SEG91945"/>
        <property type="gene ID" value="SAMN04489712_13138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="25077" checksum="A1F2BD201BB29C84" modified="2017-01-18" version="1">MTAGADAPRSVVVTGCASGIGAAVARAFAARGAHVVGVDLVPSPDAHVSVTGDVRDPDVHERAVQAAVRETGGLDVLVPNAGIHDGELGLDADPDELAERTRRVLEVDVLGYVLALRAAAPELVRAKGSVVMTLSDAAHFVGDNHAGIAYTAAKHALVGVLRWAAHRLAPDVRVNGVAPGGMPTGLRSADGGDVFTDPAAAVAGVAALNPLGSVLAPAELAESYVYLASAAARGMTGEVLRMDGGLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4Z1</accession>
    <name>A0A1H6E4Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92760">
        <property type="protein sequence ID" value="SEG92760"/>
        <property type="gene ID" value="SAMN04489712_13522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="404" mass="44005" checksum="11FEACB827078614" modified="2017-01-18" version="1">MTVAKPEYPFGPVPPAEALEIMRALRNDRPMTKVSFPFGGECWLIHRHDACRAMLEDRRFVRQPFTAGRPVPYDVEFPEFLTKTLQFMDPPDHTRFRRLVAKAFTMRRVETLRGKTQAIADELIDAMVAAGSPGNLVDAYALQLPIRVIGDMLGVPEEGRANFVQWSHALLATSGMTPEEIGESMTSLYVYLNGLMADKRADPQDDLLSALAAARDADDRLTDAEITEIAMLLVVGGFDNTANFIELGVLALLSSPEQRAALMADIDGVIPTAVEEILRHVRFAIGGGISGSAGLVPFVATEDVEISGVLIRAGEAVAVDPTTANHDDNVFADADVFDVTRSRNPHLTLSHGLHHCLGAPLARMELQVAIGTLFRRLPGLKLASEPVYQQGVLTGGMIDLPVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4Z7</accession>
    <name>A0A1H6E4Z7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_1354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92697">
        <property type="protein sequence ID" value="SEG92697"/>
        <property type="gene ID" value="SAMN04489712_1354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="6">
        <location>
            <begin position="36"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="5">
        <location>
            <begin position="212"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="7">
        <location>
            <begin position="315"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="8">
        <location>
            <begin position="662"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="829"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG92697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="845" mass="92431" checksum="3D595558CFF45753" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E514</accession>
    <name>A0A1H6E514_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cellobiose ABC transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92076">
        <property type="protein sequence ID" value="SEG92076"/>
        <property type="gene ID" value="SAMN04489712_13214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="31432" checksum="038727F22FD95CBA" modified="2017-01-18" version="1">MIITGPRGRRRGGTVAALWGAGPLTRIMLAATIVLSMFPIYWMFVVATRTNDVVGSVPPPVVPGGELGGNLARLFGDEQARFTLGLVNSAIAASTVTVSTLLFASLAGFAFAKLRFRGRNAALLVMLATMMVPVQMGIIPLYMLMAEIGWTGRLQAVIVPFLVTGFGVFMMRQYTLQALPDELIEAARIDGCSTPRIYWSVVLPVLRPAMAVLGLFTFMQTWNEFIWPLAVLDPDNPTVQYSLNLLNGAYYTDYSLMFTGTAVATLPLLAIFLLFGRQLIGGIMDGALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E617</accession>
    <name>A0A1H6E617_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92711">
        <property type="protein sequence ID" value="SEG92711"/>
        <property type="gene ID" value="SAMN04489712_1358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG92711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="485" mass="50051" checksum="F63F13E068884BE7" modified="2017-01-18" version="1">MTSIEASPKHAAGPRFGARFTLLLIALLWPAQLLSVIGLLAGNAQAQITVHFQTTQIAWFTLTTALVGTFVTPFVVKAANMYGKKRVMVVITVLGLAGDLIAALATSYSALLVGRGVAGFYTPIAMLVYAISRDVFPPRLVGPASGLIGGGVGLVALGGPFLSGWLVDHHGFRGVLWFLVAATALSLVLLLAFVPESPVREERTRIDWLGGLLLGGGLAAIVYGVGKGAEWGWTGGSTLAFIGGGIVALIAFLVVEGRVPHPMFDLSLLARRQVWTVVLATSLIGGTVFSAGTINQLLGLMPRIPGVSDGLGFTATRLAVIGIPGSVLIVAVAVTAGALARRIDARVLLAAGALCAAAGLGLMALFHHSVPQLVLSGIPFGIGMGTVAALAPIMVIQAVSPSEQSLGNGMQGMAQGIVTTVVTQLIFVVLAQNGRVLQGTQFYLDAGYTNAFWLAAGFTVAGLLAVLLIPKVRRLDEAEVGQAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7H5</accession>
    <name>A0A1H6E7H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93099">
        <property type="protein sequence ID" value="SEG93099"/>
        <property type="gene ID" value="SAMN04489712_13712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="33953" checksum="48532DC9FED65A63" modified="2017-01-18" version="1">MVDDPQAAAAERVVSVGRHAKPAEDAQEPVPEGRRVYSPAHGLSAEPTAATPAQVTPLEEAGPDPLLPGEFVRSYAATVTWKAMLVVADGAFPGLGVTGTLTRRMDELLGAAFLPAGGDGGAPFPVWPDDSGLALDLSVHFAGAGVRGLGGGTASRSAEPGWTALGVGPGSGRGAPAGFRQRHHGVLVIDTLNPQSLYRPFGGPIQPDHEPADRSGPADAADGPDAGVVIVADLRGAGTRVVNAGSLWRHACRTVTSALYDPARPESWAQTREELRSLRHVAYIDPALGLGLVVYVDAARRPWCPLGFVIEEDTVTTQANARMLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8W5</accession>
    <name>A0A1H6E8W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94152">
        <property type="protein sequence ID" value="SEG94152"/>
        <property type="gene ID" value="SAMN04489712_14323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="48"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="402" mass="45040" checksum="C9DFBCB4A28DF2C9" modified="2017-01-18" version="1">MNDFPMLSPLAILYRRHRKRNLWASIGGILGSTRTASEWAATVLADPDTVILDTETTNLVNAYAVQIAVMAVDGTLLLDTLLNPETPISAGATDIHGITDADVADAPTFTDIADRLTEALDGRRVVIYNREFDKDVLRRELDRHHRRTDLADAPDSLRKAHPATQAWMRRPRAWECAMEQYAAWWGDWSSHWGNFTWQRLGGEHNAAGDCRAVLARLYDMSTHPDGPTSNHPSPRRAGRGRTTHAPAQDTRGVNAMTPPSPIADCPDCRRSMSTGMRQPHYDHVHVVEDLPRDCRSDSRTIVRGYAVGFAGTRGFPQTWIFFADLEPAIVFGRAARMSAYDINSYGVYEAAHDTFVDQSLNRNVATLHLKAGTDLRDHDTERPILERWIQGCHPQSAYYEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8X6</accession>
    <name>A0A1H6E8X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_13814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93305">
        <property type="protein sequence ID" value="SEG93305"/>
        <property type="gene ID" value="SAMN04489712_13814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="718"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="293"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="748"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG93305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="843" mass="86124" checksum="D0B84F0D49966BE2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E958</accession>
    <name>A0A1H6E958_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxosteroid 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93474">
        <property type="protein sequence ID" value="SEG93474"/>
        <property type="gene ID" value="SAMN04489712_1398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="12"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG93474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="559" mass="60488" checksum="314CDD4BA55DEBE6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBQ7</accession>
    <name>A0A1H6EBQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_15013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94703">
        <property type="protein sequence ID" value="SEG94703"/>
        <property type="gene ID" value="SAMN04489712_15013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="260" mass="27062" checksum="838DFF76D54EC805" modified="2017-01-18" version="1">MTRRALPVLADSGPVVILAGIAAAGSFTHIRDTAREHGQHGWMAWAIAVCIDLTCVMAARERQRDKRTRRDTARLSWPTCVLVGGILLSLAANLAQAKPTVWGWVTAGTPAAAFLVAVSMLERRAAVHTARSDGSSSAGLSVPPSFGRPASSPPSSAPSPVPAVQDGARPELAASGSTPAPAEDGQTEIPLPATDPARPAGSAGPAGLAGPLVEFARRVADDHHTKHGRPITRDTLRARLGVSNQLASELLRQIRDQSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECV3</accession>
    <name>A0A1H6ECV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthase domain TIGR01720</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000053">
        <property type="protein sequence ID" value="SEG94849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94849">
        <property type="protein sequence ID" value="SEG94849"/>
        <property type="gene ID" value="SAMN04489712_1531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG94849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="588" mass="63075" checksum="D850241058CBC025" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S1F9</accession>
    <name>A0A1H5S1F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44419">
        <property type="protein sequence ID" value="SEF44419"/>
        <property type="gene ID" value="SAMN04489712_10141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="245"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF44419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="330" mass="35970" checksum="333A41DC191DA39A" modified="2017-01-18" version="1">MIEYLFTPDDVARVRFAFSPLGELVASLRVLADPSRHALHLPWVREVTPRLEGLPLEPLRALVGPVGYIPDFLTPPPRTPLPDLEAELAEVRATEPAMVVEQIAWMDTDERVPPAQRARTAPARRALTADPRGALARLTDLLVEYWAAAVEPHWPRLRGLLEADVLRRAGALTEQGTHALFADLHHRVSWDGERLTVAVNYAYRVELRGRGLLLVPSAFVWPGVLAMLPPYQPQLTYPPYAVATLWDRGPAPPPDALGALIGRGRAAVLAGLETPVSTTELARRLGVTPGAVSQHLAVLRDCGLVKGHRVGRRVLYARTGSGDALVAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S6X2</accession>
    <name>A0A1H5S6X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46154">
        <property type="protein sequence ID" value="SEF46154"/>
        <property type="gene ID" value="SAMN04489712_10196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009283693" evidence="3">
        <location>
            <begin position="31"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="4">
        <location>
            <begin position="31"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF46154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="309" mass="32216" checksum="86794116992135E8" modified="2017-01-18" version="1">MTARHRGPAAFAATLGVTGLLGLTAVPALAHGSMQTPASRSFTCRQKNPESPESAACKAAVALGGTQALYDWHEVNIADAAGRHRRLIPDGQLCSAGRAKYKGLDLARADWPATRLTGGARHEFRYKATAPHKGTFELYVTRSGYDPAKPLRWADLETSPFLTVKDPTLVNGSYTFTGTLPQGRSGRHLIYAIWQRSDSPEAFYSCSDIDFTGGEGGGTGAAPAPQPQPPSGPAAPARPTPVCPAPAEHSHSASAAPVVELDSTPASGASPAPDAGTSLKTLLTHVGTGLLLGAAATALLIRRPRRRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJZ5</accession>
    <name>A0A1H5SJZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv3520c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50916">
        <property type="protein sequence ID" value="SEF50916"/>
        <property type="gene ID" value="SAMN04489712_101245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF50916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="37856" checksum="033663C6A39DD8DE" modified="2017-01-18" version="1">MRIGMPLSYAGGFKETVEALADYEKAGLDIVFVAEAYSFDAVSQLGYIAAKTDRLEIASGILPVYTRTPTLLAMTAAGLDYVSDGRFTLGLGASGPQVIEGFHGLPYHAPLGRTREVIEICRQVWRRERVQYDGKHYRLPLPAEQGTGLGKPLKLINHPVRDRIPVQIAAIGPKNVELAAEIAEGWQPIFYLPEKAAAVWGDSLAAGKAKRDPALGELDVVGQAPLAIGEDVEGFLEFGRPMVALYVGGMGAKGKNFYNDLCRRYGWEKEAEEIQDLYLAGKKDEAAAKVPFELLRNMSLIGPEAHVKERLAAMKESGITTLNVTPIAGDHKARLALIEKVKELAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SYG9</accession>
    <name>A0A1H5SYG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="11" type="ORF">SAMN04489712_101390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54837">
        <property type="protein sequence ID" value="SEF54837"/>
        <property type="gene ID" value="SAMN04489712_101390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="10">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF54837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="223" mass="23219" checksum="7BA4C78FB1A1CAAF" modified="2017-01-18" version="1">MSLVIAIDGPSGSGKSSASKGVARALGLRYLDTGAMYRAMTWWMLAQGVPVEDAAAVAARASEPLLVCGTDPDAPTIAVDGTDVSGPIRTREVTNAVSAVSAVPAVRERLVALQREIIGTGGIVVEGRDIGTVVAPGAPVKIFLTASEEARAQRRTRDLAADPGATVAVTQAEQARRDRLDSTRKASPLTRAQDAHEIDSTRLSLPEVIEAVVRLAKENTATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SYY8</accession>
    <name>A0A1H5SYY8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_101399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55148">
        <property type="protein sequence ID" value="SEF55148"/>
        <property type="gene ID" value="SAMN04489712_101399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="45"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF55148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="26842" checksum="C66C200ACB746742" modified="2017-01-18" version="1">MPWVLVLPAVLGLAFLVLPLAGLLIRAPWSTLGTRLGEPQVLEALRLSLVTSTLATALCLVLGVPLAWVLARTGFPGRGLVRALVTVPLVLPPVVGGVALLLVLGRRGIVGRWLESAFGVSLPFTTAGVVLAEAFVAMPFLVISVEGALRGADPRYEEAAATLGASRWTIFRRVTLPMVAPGIAAGAILCWARALGEFGATITFAGNFPGRTQTMPLAVYLALETDPEAAIVLSLVLLTVSVVILAALRDRWVSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SZW4</accession>
    <name>A0A1H5SZW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56086">
        <property type="protein sequence ID" value="SEF56086"/>
        <property type="gene ID" value="SAMN04489712_101428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF56086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="22750" checksum="7E67CB6B8FF873C2" modified="2017-01-18" version="1">MDTTRWRPFALLLKAVLAVLLGLALLFPHWDRFADKAMGVRAATYPVAVMLVLAVWALRGRRGAFPWDVDLLLTAPFVIDVAGNAADLYDTVGWFDDACHYGNWLLLAAAAGLALRRWSPLPPAALALSCAGIGAIAAIVWEFFEYGVFILDTPESVGIYRDTVGDLMLGLLGATTAGLLIAALARRSGRPDRVRTDPATPARLGSRLGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TAA8</accession>
    <name>A0A1H5TAA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maleamate amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59755">
        <property type="protein sequence ID" value="SEF59755"/>
        <property type="gene ID" value="SAMN04489712_101544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008908">
        <property type="term" value="F:isochorismatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016291">
        <property type="entry name" value="Isochorismatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01398">
        <property type="entry name" value="ISCHRISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF59755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="214" mass="22808" checksum="B78573BC800AACD0" modified="2017-01-18" version="1">MSDRPDDLTADYRQAGFGGRIGLGARPALIVVDLVRAYLDPDSPLYAAAEPIVGRVARLARHARDLGHPVAFSYASYTPGGADGGWFYRKVPALRLFDEGSPWGEPPAELVPRPGDLTVTKQYPSAFFGTSLAGTLTALGVDSVVITGVSTSGCVRATTVDALGHGLRPVVVRDAVADRDPRPHEAALFDLGAKYADVHDTREVLDLWRGEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TDX2</accession>
    <name>A0A1H5TDX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60378">
        <property type="protein sequence ID" value="SEF60378"/>
        <property type="gene ID" value="SAMN04489712_101562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="315"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF60378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="489" mass="53500" checksum="C8296E6F47E9DBE6" modified="2017-01-18" version="1">MTAHDLVIKNVRVVNHDGDEPVTADIGVAGGRIATVAPGLAVEGVPEVVDGKGRLAFPGVVDAHQHWGIYNPLADDTASESRASAQGGVTSALSYMRTGQYYLNKGGDYADFFPEVLAASQGRAHVDYAFHLAPMSRRHIEEIPDLVERHGVTSFKIFMFYGSHGLHGRSANQSSFLMIPEDERYDYAHFEFVMRGVQAARERFPELADEISVSLHCETAEIMTAYTRMVEEAGELTGLAAYSASRPPHSEGLAVSIASYLAHETGLPTINLLHLSSRKAVDAAVRMSRAFPHIDFRREVTVGHLLADITTASGIGGKVNPPLRPREDVEALWEYVLDGTVDWVVSDHACCRDELKFGEPREDVFLAKSGFGGAEYLLPGMITEGRRRGLSYGRIAALTSWNPATRYGLRGKGAIAAGYDADIALVDPDRTWTVRAADSESTQEYTPFEGFELTARVTDTFVRGHRVLEDGKVIGDPVGRYLSRPYGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TIQ4</accession>
    <name>A0A1H5TIQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62762">
        <property type="protein sequence ID" value="SEF62762"/>
        <property type="gene ID" value="SAMN04489712_101638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF62762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="29357" checksum="44DCE88EA05C3643" modified="2017-01-18" version="1">MIERFSLNQWTTRYWPLPDVVAGCAAAEVRGVGLWREPVAEYGLTRTAKLLREAGVRATSLCRGGFFTADGALADNRRAVEEAAELGAPVLVLVSGGLPGGSRDLDGARDRVADALAELAPYAGRYGVRLAIEPLHPMFCSDRCVVATLGQALELAAPHPPEQVGVVVDTYHLWWDPDAYRMIGRAGREDRLAIFQVADWTTPLPAGVLTGRGLLGDGCVELRRLRQAVDAAGYDGPIEVEIFNEELWAMPGPRVLALCLERFREHVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TU83</accession>
    <name>A0A1H5TU83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase, activator-dependent family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66395">
        <property type="protein sequence ID" value="SEF66395"/>
        <property type="gene ID" value="SAMN04489712_101749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="DUF1205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030953">
        <property type="entry name" value="Glycosyl_450act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="DUF1205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04516">
        <property type="entry name" value="glycosyl_450act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1205" evidence="5">
        <location>
            <begin position="216"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF66395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="433" mass="47706" checksum="BE2499FF0923894C" modified="2017-01-18" version="1">MRVMFVTTPTKAPGHHRVPLAWALRAAGHEVRLVDRPNLVADITRTGLTAVPIGEALEADENIAASDRLREGGGIAADVPGPEDLMRIEETRPEKLTYDFMHGVLTVMTTTVFRTFSPPRTIEELVAFAREWRPDLVLWDPLVFAGPVAAKACGAAHARLLYGLDMVALMRGRYLAAMAERPPEWREDPLEEWLGPVLERYGCSFGEDVVTGQWTIDPVPPSQQLPTGIRYVPMRHVPYNGPSVVPKWLRETPKRPRVCLSLTLPHPEVTGGDRVPVAALLEALGGLDVEVVAPSSPLLRDAERDLPGNVRVVDSAPLNELLPSCSVIIHQSDVWTLHTAFAHGVPQLVLPGELWDIPMRAVQVREAGAGLTVPDVEHATAGELRALLLRLLNEPSFARNAARLQRELMSTPAPSDTVARLERLTDRHRRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TY60</accession>
    <name>A0A1H5TY60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66971">
        <property type="protein sequence ID" value="SEF66971"/>
        <property type="gene ID" value="SAMN04489712_101767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF66971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="158" mass="17275" checksum="7785D36DB0F98C48" modified="2017-01-18" version="1">MPAHVPDLVHPTAPSWPRRRMRRLRAAESLELLGGTPLGRLCLVLYGTPTIRPVNHVVEQGDVLFRTHAGSAVAEAVRAGDLLVAYAADDIDPATRLGWSVVVNGWATPVEDPAEAARHLARIDSWIGDEDGVKDQVIRIRPEVVFGHRVVVEEEDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U4W0</accession>
    <name>A0A1H5U4W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69317">
        <property type="protein sequence ID" value="SEF69317"/>
        <property type="gene ID" value="SAMN04489712_101848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028013">
        <property type="entry name" value="DUF4437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14499">
        <property type="entry name" value="DUF4437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF69317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="415" mass="46650" checksum="2CFA435AC2AFF1C8" modified="2017-01-18" version="1">MRPHVELIQEDDYVWHGAELINGEGRASERRLSVDEEDGSSSLRIDFHTDWGRGPGIHHANSEYYVLEGSMTYGGRKIGKGGYVYAPKGVPTDAITFAEGTRILHYREYGDAGFDRVDSLAHPRWEGAREDVIVIDSEAMQWDAVPNPGPMPGLFIKYLHVDPVTGFYTRLVHAQEGWADHRLAHHPCYEEAYTTQGHMEYNFGTLDLGTYFFRPARVKHGHFTTMEGGATWLLRSDGELQNWYTQNEWLRWGGEAVNYGPEGGRMRWSQSSHDLGSGPTWRSEKDIADLTASWQFQRDQGQPDARYTQHGQGVDRSILAIAKALDAARLQGGHGDDHGHSHDHDHDHEHSHDVPALDWGADPASLEHADERTDSGAHNWAQGRAWKPGDHIPAPIISSLPVRSRSRGRWDGDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5USN9</accession>
    <name>A0A1H5USN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA replication protein DnaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF77994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF77994">
        <property type="protein sequence ID" value="SEF77994"/>
        <property type="gene ID" value="SAMN04489712_1022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="107"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF77994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="29200" checksum="BD9081D169A79F64" modified="2017-01-18" version="1">MPTKAKTGRNITSELAYLTRALKAPSLAASVERLAERARAENWSHEEFLLACLQREVAAREAHGGEGRIRQARFPSRKSIEEFDFDHQRSLKRDTIAHLGTLDFVVAKENVVFLGPPGTGKTHLSIGLGIRACQAGHRVRFATAAEWVGRLADAHHAGRLEDELVRLGRIPLLIIDEVGYIPFESEAANLFFQLVSSRYERASLIVTSNKPFGRWGEVFGDDVVAAAMIDRLVHHAEVISLKGDSYRLKDRDLGRVPAAKTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UT98</accession>
    <name>A0A1H5UT98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78269">
        <property type="protein sequence ID" value="SEF78269"/>
        <property type="gene ID" value="SAMN04489712_10213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF78269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="13439" checksum="20D12E8ED2111037" modified="2017-01-18" version="1">MTAHTTSPEPEFTDLLRDLYGRLVQIEQTIGTLADSTPDGFIMWGFPQAEAAEARDALGSAPSLAGFMPPPAELTDTHATAESLADLTTEIHRTLITASAKATDSADRHACLSAAMFAGRLHESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UV98</accession>
    <name>A0A1H5UV98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78401">
        <property type="protein sequence ID" value="SEF78401"/>
        <property type="gene ID" value="SAMN04489712_10219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF78401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="491" mass="52574" checksum="E79EC493F020591E" modified="2017-01-18" version="1">MAGEIRTYGGWRRRRGIGLLGLDTTATFVTLGVALAAVVLGTVRPGLLLYLGPPIVITGVLGLVRVGGTPVAMLALVRVRWWWGSWRGHARYRAGVVIDHPRAFQLPGVLAPLTLLSAEDGYGGRYGVVWDRRAGLLTATLRVVPASTWLADRTDTDTWVACWGNWLASLGHQRAVRHVTVTVDTAPEPGSTLADAVSAMIDPRAPAPARLIIGEVVNTAPAAAADVDTRMSVTFDPKASPTAPKDLLDAVAELGRTLEGLESRLGLCGVTVVGRATAAEIAGTIRTAFDPDARGEVNRLLSRPSSQEVLSWADAGPVHAVEYTDRYVHDSGISVSWAWHEAPRQAVHSNVLARLVAPGPYPKRVSLQYRVLPAAQATKVLESEVNAAAFRSAFRRKTGRDETARDAHDAARARQAAAEEAMGAGVCLVSMYVTVTVTDEGELRRAVAHTESAAESSKIRLRRLWGSQAAGFATTLPCGICPPDLTSRWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V127</accession>
    <name>A0A1H5V127_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase involved in cellulose biosynthesis, CelD/BcsL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80177">
        <property type="protein sequence ID" value="SEF80177"/>
        <property type="gene ID" value="SAMN04489712_10293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="162"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF80177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="40722" checksum="04B09CD7584C27EB" modified="2017-01-18" version="1">MHITVIRPHELGNTELAAWRAMQAARPRLANPFMSPGWALAVDRVLGGGARRGARVAVLEDGPDLVGFFPFELTGRGTGMAIGGWLSLGQGIVHAPDLDRLDARELLRGCGLGVWEYGTLVEGQPWFEPCTTKTLSTVIMDLSGGFDGYGKTLKERGSKLLAKTRTKERKLGREVGEVTFDFDVRGTAALDLVRQWKSQQYQAMGRADRFARPWVVELTDLLHGVHEDDFGGCLSMLYVGGKPVAGHFGLRSRHTLSAWFPVYDPEYARYSPGIILHLHMAEEAAKAGIQELDLGPSAGWPYKRELRSHEILVGEGVVRRPSLSAAAHWARHAPVARARRVVLENKRLYGLADRAMRRYGSYRTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VPI4</accession>
    <name>A0A1H5VPI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88838">
        <property type="protein sequence ID" value="SEF88838"/>
        <property type="gene ID" value="SAMN04489712_102393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF88838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="22568" checksum="31283D0ACA08B33A" modified="2017-01-18" version="1">MELLDEVERARRERYVRPADRDRFTVGVAVTRLAAGALLGVAPERVPLDRTCAGCGAPHGRPVIDGGPHLSVSHSGERVVVALTGGPVGVDVEEDAGRLTEGVAGQLLGPDEAADLRDLGPAARRRGLLEYWTRKEAVLKATGDGLRVPLTDLRMSAPDEPPRLLAWEDRPGLAGRLTLRTLTPGPGYAACLALIDQPDARIREESAGPLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VWP5</accession>
    <name>A0A1H5VWP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91291">
        <property type="protein sequence ID" value="SEF91291"/>
        <property type="gene ID" value="SAMN04489712_102480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021607">
        <property type="entry name" value="DUF3224"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023159">
        <property type="entry name" value="SO1590-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11528">
        <property type="entry name" value="DUF3224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159238">
        <property type="entry name" value="SSF159238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF91291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="14786" checksum="A1729439EEDA44BE" modified="2017-01-18" version="1">MAAIVATMAVMTQNASGTFDITGWDEYAKDAGPDGVVVARVRVTKAFHGDLTGTSVTEIQTVTTDSGPSAYVGIERFEGALHGRKGTFVLQHSAGSDAEGQWLKWLIVPTSGTGELAGLRGGGDIVVDENGGHSYSLAYDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VZ78</accession>
    <name>A0A1H5VZ78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92328">
        <property type="protein sequence ID" value="SEF92328"/>
        <property type="gene ID" value="SAMN04489712_102520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="239"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF92328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="459" mass="52258" checksum="B4A24403093EAFBA" modified="2017-01-18" version="1">MKSNRIRFWEIRPNYTEKSGKRVVRSYTVRWTVAGREKSETFTRKSQADRFRGRLMSAAEREPFDVETGLPDSMRRERSSMTWYKLACAFIDDKWPRLAAKGRVSVVEGLMAVTPVLVKSQRGAPDPKTLRLALRNWAFNPPRRESDKPEEIAAALRWLEKASVPVSALEEARTVAKALDACAMNLNGKPSKPQYYRRRRRGFYGALKYAVREKQLSANPLDTPDEVDWKPPEVVHAIDRRRVPNPDQVAALLEAVRQVGKTQGPRLVALFGCMYYAMLRPSEAINLRKDDCTLPAEGWGLLELEEVKSAAGRRWTDNGEVHETRGLKGRPKDTVRRVPIPPELVELLREHIDTYGAGLDGRLFRTYRGGVYQPSTLWRVLNLARQKALTPKQVKTPLAGKPYDFRHAGVSWRLNAGVPAVYVAEWAGHSVEVLQRIYAHCLDGDDGRWFQRMDAALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W3C1</accession>
    <name>A0A1H5W3C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93651">
        <property type="protein sequence ID" value="SEF93651"/>
        <property type="gene ID" value="SAMN04489712_102564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF93651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="505" mass="52828" checksum="4A7A6914ABB80699" modified="2017-01-18" version="1">MSEWVGRTATEIAAAVQTGQVTAREVVQRHLDRIRAIDSELGAFVRVRGERALAEADEVDARADRAGLPLAGVPVAIKDNIPVAGEPMRNGSLATPAAPQRADHPVVARLRAAGAVVVGLTNLPELAIYPFTDNAFGVARNPWDTRRTPGGSSGGAAVAVAAGMVPIAHGNDGAGSIRIPSANCGLFGIKPGPGVVPAEIGSDSWGGMSENGPLATTVSDAALALSVMADDPALAAPPVPEGLRIALSVKPPAPGVTIQRELRAAIRTAGRELVGLGHDVRRDDPDYPLWAGPAVISRWLAYPAADAEPYLAHPDLETRTRRHARAGRVGRGRAPVRAPRRAGDADPGPPGAGRPRGRRALLAAQRRHVPDLRAADRRLEPGGLSGRLGPDGRQLRGPADRRPARGRPRQRGPAPGPGRPAGGRPPLVPPCPGLQPVPPRRGHRTVTGRGRPRPWKRHRGARHLRRAPRWVVFGQMSGGGAGAVTNGEGHVPLRVDLGVQGLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W4L5</accession>
    <name>A0A1H5W4L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94449">
        <property type="protein sequence ID" value="SEF94449"/>
        <property type="gene ID" value="SAMN04489712_102587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="27"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="200"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF94449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="43439" checksum="A84E05FFBEA54A12" modified="2017-01-18" version="1">MTRGPAHRGRGLRSAIVNWRDPWHPAAGGAERYAWELARRLAAGGADVRYVTARAPGQRRRERVEGVELVRLGGRFTVYPLVLLWMLVRRRRFDAVVDCQNGIPFFTPWVLPRRVRVFCVVHHVHSEQFGLYFPSWLAWVGRLLEGPVARWTYRRHACVAVSPSTRRAMRERLRWKGPIHLVPNGLTLPSEPVPPARGIGDPALVCVSRLVPHKRVERLLDLAERLRGQWPGLRVHIVGDGPEAGALAAGIAGRGLGAVVTVHGFVSEEDKAALVAGAVLHLSTSRGEGWGLSVIEAAALGVPTVAYDVEGLRDAVRDGVTGWLVRDGEDLSDVVERALKELDDPLRRIEVSAACRGWAAEFDWARTADRMAALLTAEEERIAGRPPLPEGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W943</accession>
    <name>A0A1H5W943_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine--fructose-6-phosphate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95786">
        <property type="protein sequence ID" value="SEF95786"/>
        <property type="gene ID" value="SAMN04489712_102629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="34"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="201"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF95786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="36201" checksum="8FD80762672BC526" modified="2017-01-18" version="1">MTAAMTTSRMRAEIGEQPQALRRTIDALLPRMSDVGLLARGTRQVLFIARGSSDNAAVYGRYLVESQVGRLATPAAPSIATTYRRRLDLTGVLAVAISQSGRTEEIVETLEWAADCGARTIAVTNGPGSPLAETAEVALITEAGDEVAVPATKTYTTQLAALSVLALGLGAPVDQTELRRVPDEVERLIAATEASPALEAVVAGLAEVPGAVVSGRGIAFGTALELALKIKEACYLHAMGLSYADLLHGPIAVVDSATPAILVAADEGPTLPGTVALARRVTGAGAHAYGIGGGDGLARACSHALPGPRLPEWVAPLGLIVPGQLVVEALARRLGHDPDVPRGLNKVTQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W982</accession>
    <name>A0A1H5W982_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96005">
        <property type="protein sequence ID" value="SEF96005"/>
        <property type="gene ID" value="SAMN04489712_102635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF96005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="11263" checksum="BE6ED3EDEC4DAD1B" modified="2017-01-18" version="1">MAGSHGGRPSSWAVVALAFIGFVIGGVALCLGPNWLLFWIGGAVVVASGLLGMVVGIFSDVVLDEPRVLPEVVNYSLFGAQTDERRGGPYGERTSHALTSDPETKPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WDL8</accession>
    <name>A0A1H5WDL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97575">
        <property type="protein sequence ID" value="SEF97575"/>
        <property type="gene ID" value="SAMN04489712_102683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009288166" evidence="1">
        <location>
            <begin position="33"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF97575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="15088" checksum="75A17D5BE4F4E699" modified="2017-01-18" version="1">MGRTNNRLAQLAVATAVVAGGVGVVTAPAASAASVTCTIDSVTNASTAGYKYVNVTCKEGSISPPDFIYDVQIWGEDTWSDDYLATVYPPNYYPASLYVHGSVLNEDYGDKDDIYVKVRFQKSTGGLYSVRSNTVHGWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XWL8</accession>
    <name>A0A1H5XWL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16058">
        <property type="protein sequence ID" value="SEG16058"/>
        <property type="gene ID" value="SAMN04489712_103441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG16058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="323" mass="36776" checksum="F9F0CF37B122596A" modified="2017-01-18" version="1">MPSRSPGARPRAARLIRGRPWLDPVLDRAVDAVRDRYPRVGAAALAESRADPELRSLRVEALAKAAAGWSRGIEALLAEDPGNPDLWLWLGRTRVEEAWRSRPDARARSVQAAGYIAYTKRMKAAREPLMRAAEIFRDDPVPWESMMWLALGLDLGREDKDALWAQAHRRWPTLYGAHVARVVTLSPQWGGMMEEMFDFARVAMSMAPREDPRAALIPLAYFEYFVQERSGIIRGTSSWFSAEECRDVEIAARRWFEGPRPHPRTIEAHNFFGAAFHLADARRPARQHLIRTHGRPSGLPWSYFGDETDQYVKACRHLNLDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YJI6</accession>
    <name>A0A1H5YJI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24299">
        <property type="protein sequence ID" value="SEG24299"/>
        <property type="gene ID" value="SAMN04489712_10451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045684">
        <property type="entry name" value="DUF6191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19690">
        <property type="entry name" value="DUF6191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG24299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="105" mass="11832" checksum="7897829167754264" modified="2017-01-18" version="1">MAAIAFMTIPGLVIALVAFAVLDRVGLWAHRRFRLPWRRDEVGRPISAVALGELDVFFHGTHRHQQEQRRSSLMLRDEENDGAPPRTHIDLNAGTAIVRRPSDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YR71</accession>
    <name>A0A1H5YR71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26524">
        <property type="protein sequence ID" value="SEG26524"/>
        <property type="gene ID" value="SAMN04489712_104138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG26524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="19657" checksum="087304EBD13A750E" modified="2017-01-18" version="1">MRPEKPLYERDPEAWRAHLAEGNATQPRKRVGADALVRDDSGRLLLVDPKYKPDWDLPGGMSEANEPPADTVRRELKEELGLDIRPGPLLCVDWVSPHGPWDDSLMFIFDGGILGHDRIDDIKMLDGELAAFAFCDEGQAAERLRPYVWRRVQAALEGLQAGRAMYLHDGWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z7V4</accession>
    <name>A0A1H5Z7V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_104357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31426">
        <property type="protein sequence ID" value="SEG31426"/>
        <property type="gene ID" value="SAMN04489712_104357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="168"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG31426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="43375" checksum="7F9197E973ED40C8" modified="2017-01-18" version="1">MAKRDFGSVRQLPSGRWQARYRDPDGKRRTAPQTFTTKREANRWLTLKAAEIERGEWINPDAGKITLGEWGTRWLESVRPSLKPKTYASYLSLFKTQVKPRFGESALTSIRPMAVSEWIADMSGRGLSASRIRQAHVVLALMMETAVNNELIRVSPCVGTKLPRVVVRDPVILTQDQVAALVKAAVPPHDLLIEIMAYTGLRIGEAFALRRRSIDLEAACIRVTETLVEISGKTSFGTPKDHQVRDVEIPAFLVRRLRAHLDEMEDQSPNALLFVNRRGNPLHYNAWRTWKFDPAADKAGLDSVKPHDLRASHASWVADRWGVLAAGRRLGHSNTTITTRHYARRLEGRDTDVARGLEALRDGDKAPRARTGHDEDDDDPPGVPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZU29</accession>
    <name>A0A1H5ZU29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG39998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG39998">
        <property type="protein sequence ID" value="SEG39998"/>
        <property type="gene ID" value="SAMN04489712_10510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG39998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="37691" checksum="203AECE26A91ADA4" modified="2017-01-18" version="1">MSRPITLFTGQWADLPFEEVCRLAAEWGYDGLEIACWGDHFEVDRALAEDDYVRGRLDILDKYGLKVWTISNHLVGQAVCDHPIDERHQDIVPARVWGDGEPEGVRQRAAEEIKNTARAAARLGVDTVVGFTGSSIWHTVAMFPPVTEAAIERGYADFAERWNPILDVFDQEGVRFAHEVHPSEIAYDHWTTVRALEAIGHRPAFGLNWDPSHMVWQDIDPVGFILDFADRIYHVDCKDARRRTGNGRNGRMGSHLPWGNPRRGWDFVSTGHGDVPWEDCFRALNAIGYDGPISIEWEDAGMDRLIGAPDALNFIRGLTRIEPPAASFDSAFSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZXI3</accession>
    <name>A0A1H5ZXI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Squalene-associated FAD-dependent desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40911">
        <property type="protein sequence ID" value="SEG40911"/>
        <property type="gene ID" value="SAMN04489712_10556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017830">
        <property type="entry name" value="SQase_HpnE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03467">
        <property type="entry name" value="HpnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG40911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="439" mass="46840" checksum="4FF85F0462C075A7" modified="2017-01-18" version="1">MSVVIVGGGLAGISAALALQEVGVPVTLVEARPRLGGATHSFHRRGLAVDNGQHVFLRCCTAYRGLLERLGTHHHVHVQDRFDVTVLRPGGVAGRLRRSRLPGPLHMLPALARYSALPVADRLRTVRAALALRRLDPGAPELDEISAGRWLAAHGQRERARRELWEPLLMAALNAGLDEAAMGAAGMVCRTALLGRRDAADIGVPALPLGDLHGAAALRRIEEGGGNVLLRARAEAVTADPKVVVNGTPLGADAVILAVPHEAAARLAGEETCPDRDRWPALGAAPIVNVHVIYDRPVLDLPFAAAVGSPVQWVFDRTAPSGLAEGQYLAVSLSAADRWIELSTAELRAVFVPELARLLPAARHARVLDLFVTRERRATFRQAPGSTAGRPGAATRTPGIFLAGAWTATGWPDTMEGAVRSGLTAARLVRRHLREVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZL3</accession>
    <name>A0A1H5ZZL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_105107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41928">
        <property type="protein sequence ID" value="SEG41928"/>
        <property type="gene ID" value="SAMN04489712_105107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG41928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="302" mass="33432" checksum="CEE47398E3468784" modified="2017-01-18" version="1">MNAGDDRRVAVFEEHRDLLFAVAYRMLGTAADAEDVVQDAWLRWDAADRARVDDPRAYLVRITTNVSLDRLRSARVRRETYVGPWLPEPVLTSPDVAEDVELAESVSMAMLVVLETLSPLERAVFVLREVFGYPYAEIAQTLDRSETSVRQLGTRARKHVQARRPRFESGRDERRQAVERFFAAAVGGDVNELMQVLAPDVTLWSDGGGKVRAARRVIVGADKVGRWLDGVSRQSIGGVRLSGMRIAQADVNGAPGLVFHGPDGPLMAVTVDADDRGRVTEIHVVVNPDKLRALAAGRRLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2L8</accession>
    <name>A0A1H6A2L8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_105148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42602">
        <property type="protein sequence ID" value="SEG42602"/>
        <property type="gene ID" value="SAMN04489712_105148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="107" mass="11943" checksum="D67D72BB51C7664B" modified="2017-01-18" version="1">MTYVIAQPCVDVLDKACIEECPVDCIYEGKRQLYIHPDECVDCGACEPVCPVEAIYYEDDVPDQWKDFYKVNVEFFDDLGSPGGASKVGKIDKDHPIVAALPPQNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A395</accession>
    <name>A0A1H6A395_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribosyltransferase exoenzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43223">
        <property type="protein sequence ID" value="SEG43223"/>
        <property type="gene ID" value="SAMN04489712_105185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003540">
        <property type="entry name" value="ADP-ribosyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03496">
        <property type="entry name" value="ADPrib_exo_Tox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="ADPrib_exo_Tox" evidence="3">
        <location>
            <begin position="444"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG43223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="621" mass="67673" checksum="0AECB95F9E6B974F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A4Y3</accession>
    <name>A0A1H6A4Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43491">
        <property type="protein sequence ID" value="SEG43491"/>
        <property type="gene ID" value="SAMN04489712_105199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="257"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG43491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="389" mass="41690" checksum="A10FDD09680706CC" modified="2017-01-18" version="1">MIRRTRGRTGDEGLATTLLVLYVSLALAAATLLIFKIAEAGDMRTQAQIGADAAALGALEPLRNQAIDLALEGISPSGVGYWMTNTEPEVPAKRYAGENETDLVGEVKLSGRLGTTAKVSTVTRKCQLKNERNLTDKERRALQEGEDLCTGTDGEKGVGRAGKATAVGRLIIPDCVYPPIPGDQLEDGNPDYNRLVCDGVQVWPNGDRDRVAKMFKLRLVDAEDPVAYKGGPDYDDIFPPGQVGPLPQLPELPADASDLIKKILAYAYAQIGKPYLWGGVGPSAFDCSGLIYAAYKSAGVAIPRTTFTQWPFGVRVPGGAEKPGDLIFFNSGPGSGPNRPGHVAMVVDPEKKLMIEARCRLCGPISVTSYANRPNVMGFTRPLARFGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AAT8</accession>
    <name>A0A1H6AAT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_105310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45561">
        <property type="protein sequence ID" value="SEG45561"/>
        <property type="gene ID" value="SAMN04489712_105310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="11">
        <location>
            <begin position="49"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="12">
        <location>
            <begin position="330"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG45561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="546" mass="59723" checksum="0B6CD3C7342119ED" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABF1</accession>
    <name>A0A1H6ABF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="11" type="ORF">SAMN04489712_105323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45781">
        <property type="protein sequence ID" value="SEG45781"/>
        <property type="gene ID" value="SAMN04489712_105323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="10">
        <location>
            <begin position="199"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG45781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="311" mass="34358" checksum="47A0B42738043C3C" modified="2017-01-18" version="1">MSTRDLLVLGTASAVPTKSRNHNGYLVRWDGQGLLFDPGEGTQRQMVRAGVAAHDIDWICVTHFHGDHCLGVPGVIQRIARDGVEHPVRAVFPAAGQHYWERLRHATAFRDTEVVHERPLDGAHAEIDSGGSPFTLSARRLDHPVEAYGYRLEEPDGVTMLPDRLAEHGVGGPLVGRLQREGRVTARDGRTVTLEECSVPRPGQKLAFVMDTRLCAAAYELADGVDMLVIESTFLEEDAALAREYAHLTVRQAGEIAAKGGVRRLVLTHFSERYRAEDFPRFAEQAAECYGGDIVLARDLDRISVPARRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AK46</accession>
    <name>A0A1H6AK46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49078">
        <property type="protein sequence ID" value="SEG49078"/>
        <property type="gene ID" value="SAMN04489712_105513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG49078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="240" mass="25672" checksum="010DBC62FEDFCC4A" modified="2017-01-18" version="1">MDNFFLRRRRPSTSCLAVAVIVVVGCLIAWLLVQALTTHTEPGTRRPAATLPAGIAPGDDDTLTAGPLRVLAGRAVVKDVPVGFPHTTAGAVSAAVHYWGQIGSTLKPARAYVIGRIVADPAWKTAPQDLAQGPVHTRRMLGLPTAGPVPQGAAVRLTPMAYQLRDVTPDAVFVLLLAYYETTVPGWEPETGPGVFPAQLRWIAGDWKLPAPTQDADYSELRAPPGSAEAMALGWRPLWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ALD9</accession>
    <name>A0A1H6ALD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49202">
        <property type="protein sequence ID" value="SEG49202"/>
        <property type="gene ID" value="SAMN04489712_105520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG49202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="81" mass="9253" checksum="3E4C46931B32AD97" modified="2017-01-18" version="1">MVRTWRGSAFVALPKSRMAEYGSSWLRYAWFRYCWLVVGEGEVWLRSRKGDYPIPRDEVARGSPVARTPVVWGQVMVSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AVE7</accession>
    <name>A0A1H6AVE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52027">
        <property type="protein sequence ID" value="SEG52027"/>
        <property type="gene ID" value="SAMN04489712_1061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG52027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="33" mass="3604" checksum="D1D798134754F14D" modified="2017-01-18" version="1" fragment="single">TVRNHVSNIFMKLHVADRAQAIVLAREAGLGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXP1</accession>
    <name>A0A1H6AXP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trypco1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53124">
        <property type="protein sequence ID" value="SEG53124"/>
        <property type="gene ID" value="SAMN04489712_10674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045794">
        <property type="entry name" value="Trypco1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19493">
        <property type="entry name" value="Trypco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="109" mass="10889" checksum="DB9195DD89A0C2BA" modified="2017-01-18" version="1">METRDFGPAYGNQVRIAVTDGDVSASADYAGALSTAIQAVAEAVQHAVETLAEGDSGPAGCEVSFGLRATAAGALAIAAEDAVIQVRLTWSRDSGQDGGLTGLLPGLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYQ0</accession>
    <name>A0A1H6AYQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53484">
        <property type="protein sequence ID" value="SEG53484"/>
        <property type="gene ID" value="SAMN04489712_10695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="129" mass="14304" checksum="6E02B49BD58F907B" modified="2017-01-18" version="1">MRGRTDGNAVRMLGWVLCLCLCWSAVLMPASWGEGDRRGASIAAPDHLMGEQREESEKLPRKAEASRLREADDNVGAPARPVMVVMLWHLLAQWRAGLVLRLYGPGDGPWWEGLPDMGAVLARIQVLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2X8</accession>
    <name>A0A1H6B2X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luciferase family oxidoreductase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55213">
        <property type="protein sequence ID" value="SEG55213"/>
        <property type="gene ID" value="SAMN04489712_106213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG55213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="36273" checksum="3AE197EEAF8DD556" modified="2017-01-18" version="1">MSIPFSVLDLAPVVSGSTSAQALRNTLDLARHTERLGYTRYWLAEHHNMPGIASSATSVLIGQVAAATSRIRVGSGGVMLPNHAPLVVAEQFGTLEALYPGRIDLGLGRAPGTDPATAQALRRSTSPLSADDFPEQVIELQRYFDEHSPVTPAAGNRPPIWLLGSSGFSARLAGLLGLPFAFAHHFSAENTLPALELYRESFRPSADLERPYAMIAVSVTAADTDERARELARPQALQFLRLRQGHPGPLPSPEEAAAHPYTPLERDLIDHRLSTQVVGGPDTVRTQMDTLIKATDADEVMVTTSVYDHTDRLRSYDLLATLYNLTATEPAQSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B8N8</accession>
    <name>A0A1H6B8N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56516">
        <property type="protein sequence ID" value="SEG56516"/>
        <property type="gene ID" value="SAMN04489712_106318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="28153" checksum="575C06CB56DCFA3F" modified="2017-01-18" version="1">MPPTDRIAAELHRLGERRATGMLRVGAEGAFFLVDGAVTFAQHRRAPGLDELVTASGRVPAEQWWRDRRAGRPPGGLGRAELELFALLTTFDAGYFLLGSRSEAHFAEDVRHDLAPICRIAPGTLAFEAEHRRALLDAQWPSAQADEAPVVPVRRLRRQRLVLTGLQAEILLNADGRRTPAELARDLGRTAYGCLLAVRGLAADALIEHAGTPRQPPGAEPPAEPPAEPSAEPSAVPIRWGPVDQDVLHRLRAALEQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BEB4</accession>
    <name>A0A1H6BEB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58665">
        <property type="protein sequence ID" value="SEG58665"/>
        <property type="gene ID" value="SAMN04489712_10710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="55"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG58665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="437" mass="45548" checksum="900A398E183EBB7A" modified="2017-01-18" version="1">MHEPYDLVLRSRRVLVPDGERSLAVCVRGGRIAALEPRDAALRTVRDIDLGEVALLPGLVDTHVHVNEPGRTAWEGFASATRAAAAGGVTTLVDMPLNSLPPTVGTAELEVKRAAARGRVFVDVGFWAGAVPGNVPALRALHEAGVLGFKCFTAPSGVAEFPALDPGGVRAAMTEIASFGGMLIVHAEDPARLSEPAGPGYPEFLASRPGAAEGAAIAMVAELSRETGCRAHIVHLSDGGAVPALRRWQGQGVAISAETCPHYLTLSAEEVPAGATEFKCCPPIRESANRERLWGGLAEGTIRCVVSDHSPCAPELKRGDFATAWGGISSLQLGLPVVWTAARARGHSLADVVRWMASGPADLVGLAGKGRIAVGHDADLVAFAADASFVVDPGALHHRHPLTPYAGRELTGVVRGTWLRGEPVDPAGAPRGRLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BH96</accession>
    <name>A0A1H6BH96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized SAM-binding protein YcdF, DUF218 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60128">
        <property type="protein sequence ID" value="SEG60128"/>
        <property type="gene ID" value="SAMN04489712_107111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="3">
        <location>
            <begin position="86"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG60128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="28730" checksum="A5CE0A75757FD052" modified="2017-01-18" version="1">MTLEVEVPDFGSGEHEPAERDLSVPAPEGEEPKNDDRPGKPRKRRRWLFWSVMVLLAVLAVAVLTPLTVGWRVWYQARQDETPRSDAIVVLGAAQYNGVPSPTLRWRLEHAVTLYRKGVAPAIVTVGGKMPGDNYTEADTGRNWLIKERGVPADRVVSVPVGNDTLESMQAVGRRFKQLEWDSAVIVTDPWHGLRSKKMAEDNGIRAAASPTRSGPSVQTRDTQFNYIVRETGGYLSYVLFGRSVRSPSELRPSVTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJ54</accession>
    <name>A0A1H6BJ54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, Tic20 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60791">
        <property type="protein sequence ID" value="SEG60791"/>
        <property type="gene ID" value="SAMN04489712_107157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG60791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="189" mass="19436" checksum="6A35C01048F31895" modified="2017-01-18" version="1">MAYGSPPPAPGPGRQPGYGGQAPWQQQPSPGPYGPGPQAPPPGPPGPYGPGPGPGPGQYGPPPQPPAHGLGGPTRQAPTGPPSPQEQNWALMAYLGQFLTSAIAPAVVLVTKGGSPFVRRHAVQGLNIAIGAIVVWVVGILLTQLMDALALIPLAYTAAVMYFLVRAAITVNRGEFLRVPAFIAWPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BL98</accession>
    <name>A0A1H6BL98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_107216</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61470">
        <property type="protein sequence ID" value="SEG61470"/>
        <property type="gene ID" value="SAMN04489712_107216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="13">
        <location>
            <begin position="533"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="550"/>
            <end position="557"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG61470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="884" mass="94178" checksum="994AFD65A980BA96" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BQQ2</accession>
    <name>A0A1H6BQQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein HdeD, DUF308 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62536">
        <property type="protein sequence ID" value="SEG62536"/>
        <property type="gene ID" value="SAMN04489712_107303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG62536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="179" mass="18612" checksum="A1ED5E0B48F2344E" modified="2017-01-18" version="1">MIAVRGVVAILFGLAAWVWPGITLLALVLLFGAYALVDGIFALVAAFRGRPGGSRTWLAVTGAVGVAAGVLAFLWPGVTALVLLMLIAAWAVVTGVFEIVAAMALRREIEGEWWYAAGGAISVLLGFLLFIWPVSGALAVVWLIGLFSILFGAALVTLSLRLRQQATAARPGGTAAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7A6</accession>
    <name>A0A1H6C7A6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68617">
        <property type="protein sequence ID" value="SEG68617"/>
        <property type="gene ID" value="SAMN04489712_1097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="15180" checksum="01536CC8DF72F79C" modified="2017-01-18" version="1">MTDDILVVGDIPARTQAAVTDVVKALEKAFNTKDPIALSEQFARQTSWSNAMGIRLDGRRAIAESAAPAMQGFLRDSYARYNVVKQLEIAPGVIAVNVAQTPTDSSGNPVEGAHGAALYVFAEQEDGWKIVAGQNTAIEPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C859</accession>
    <name>A0A1H6C859_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69170">
        <property type="protein sequence ID" value="SEG69170"/>
        <property type="gene ID" value="SAMN04489712_10957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="443" mass="49528" checksum="CD93B76F6864CA05" modified="2017-01-18" version="1">MPKQPRRIDPQESPRHLLGAALRHWRHEVRNIDLRELAERAYVDFSQIAKWERAERPAPTDAITRIDTELQAGGHLIALHALVTELENLRIRQEQPTREVDMAQFDDQRRRLLQTLTALGVASATTALEPIRHALASSLPNAAQYAVSDWEEIAVEHSHTYLVTHPAEVLRDLSVDVASLQYAIKNSESEPTARALCAVGAHMTMLMAMALGGLDMRRDARNWWRVARHMADDAEKASLRAWVRGFEAMSSLYRQRPLHVVLTMTDEAIEIAGDDPDPSVLEAMATRAQALSAMGRLREAERVLHQMEPIFEKQPSISPYEDINCGLWAETALLHTRAWVYAHAGSPAADDALDAALAAYPPDMRRQAVQIKLLQAVSLVLNGNITEAVEHARSTMEALPSTQRTTSLKKGAHDVLLLIPESESNRPPVKEYRDFLTLPAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CA33</accession>
    <name>A0A1H6CA33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69485">
        <property type="protein sequence ID" value="SEG69485"/>
        <property type="gene ID" value="SAMN04489712_10988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="208"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG69485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="415" mass="44162" checksum="645B047E03309871" modified="2017-01-18" version="1">MGVRRVARAGWDDLAPNAVGPLLPLSPGTGWAPHVLVGALAVMLAGFSWHTLLMDYGLANEQAAVLGITHALALLVCLYWPMAGWWLSLAMVVVTALSAASVRPLAGGPLWTGPSLAVHLCVLALVGLRVRPRVLVEMWLLTVAAGVVLSAELPRREEFPGLLEPVLLAGAALVAAGALRGRGEAMRRLARQQQISERERSRRELLEERARIARELHDVVAHHMSVVAIQAEAAPYRVADPPAELARGFETIRANALAAMDELHRILGLLRNETAEQEHRPQPTLAGLEELADSVREAGLTVALTVSGERRQVSSGVGLSAYRIVQESLSNVLRHAPGADVRVEVEYGPDRLEVRVANGPPAGRPAISNGSGHGVAGMRERAVMLGGELAAGPRPDGGYQVTATLPLPDAEGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJJ1</accession>
    <name>A0A1H6CJJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72943">
        <property type="protein sequence ID" value="SEG72943"/>
        <property type="gene ID" value="SAMN04489712_11053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG72943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="18795" checksum="F640FC9847719502" modified="2017-01-18" version="1">MADEEYLEFASARSGHLFRTACLLTGDWHLAEDLVQETLGKVYRSWRKVSRADNPAAYSEAILVRTFLSHRRRRSSAERPTASLPDRPGTGDAVDGTALRMTLLDGLARLPVQDRAVLVLRFWEDRSVSETATVLHLSAGAVRNRSMRALERLREVLGDQFLDVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMM3</accession>
    <name>A0A1H6CMM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74211">
        <property type="protein sequence ID" value="SEG74211"/>
        <property type="gene ID" value="SAMN04489712_110200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295012" evidence="1">
        <location>
            <begin position="34"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="326"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG74211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="418" mass="44836" checksum="136D1892B8220EE0" modified="2017-01-18" version="1">MGFPGGKRIAALVAAVGVLGAGAVHLGTGTASAAFSPRSGPVFNNPTGNTAQQYAIMRQIERNIDTAPKGSVIRVAVYSITLNSFADKLIAAHRRGVYVRFLMDQHSVNGVWQRLASALGTKVNVQTSASSYAALCSGGCMGRYHGKDGAAVGSLHTKFFLFSGGGKPTVTISSANPTATQAEVAWNNSYTVVGNKSLYNAYVKNFNDMSKGALGSYNRNYYWTSGANPKAYFWPKSKGSNDTILGMLQLVTCSKTYPSQVRVAMFQWTDGRLPLARQLVSMAAKGCRVTVIYTKDSISPAVQSTLAKSKVVVRDTTFGRTPQGYAEHYTHNKYLLIDGRYGGTNGSKIVMTGSANYTVNGLYYNDESNLKLTGATMYAAYLKNFNDQIASVPALTAQQRAEGRLPAIPVDPAQLRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CR89</accession>
    <name>A0A1H6CR89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75257">
        <property type="protein sequence ID" value="SEG75257"/>
        <property type="gene ID" value="SAMN04489712_1115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="55"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="22981" checksum="6B9D140AF2DB9EC4" modified="2017-01-18" version="1">MTASSSYLRVTAEAYDAVAALYADLFRGALDDQPLDRAALAVFAEVVRTAGGGPVAELGCGPGHVTAYLRKLGLDVSGLDLSPVMIDLARREYPDLRFEVGSMDALDLADGELGGIVSWYSVIHTPPQELPAYFSEFCRVLAPGGHLLLGFFESEGAPVTPFDHKAAPAYRWPIDDLAALARQAGFVEVGRVLREPGEGERYRQGRLLMRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT33</accession>
    <name>A0A1H6CT33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_111112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76038">
        <property type="protein sequence ID" value="SEG76038"/>
        <property type="gene ID" value="SAMN04489712_111112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295180" evidence="3">
        <location>
            <begin position="26"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG76038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="28220" checksum="7E21ACC28F7C9DBC" modified="2017-01-18" version="1">MRSGRAIAVVLAAAIAVLHTPPAQADPRRGTPGFCPDAGGVTVVIDFQELGGPSIVRCAPGPQDTGLAALQNAGISVTGTARWGLGFICRIEGKPGPSSEPCIDTPPASAYWSYWHAPNGGTWHYSDWGVKNRRPPPGSFEGWSFSKNRTAATNPQPRIAPVRPERPKDPDSPAPRSSGRPSPSTSASPPPSASPSASASSTPTVSDSAEPTPGPTDTPTQAPGWTGGAELPPAVPSAASEPMPVSTALGIGFLLSLLIAAVYATVVRARRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV19</accession>
    <name>A0A1H6CV19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76814">
        <property type="protein sequence ID" value="SEG76814"/>
        <property type="gene ID" value="SAMN04489712_111210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039561">
        <property type="entry name" value="Peptidase_M15C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13539">
        <property type="entry name" value="Peptidase_M15_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M15_4" evidence="2">
        <location>
            <begin position="148"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="24826" checksum="085061A54C1AC1C7" modified="2017-01-18" version="1">MVMMLGAVLAGCGGGGSGDNGAGSPVSPPRATGPATSPPSPSGPPRFTADIKKVSRPDLKYSWREGCPVPVSGLRAIDMNHWGMDGKVHNGRLIVNASAAEELTGVFHKLFDRKYPIARMEPVDKYRGSDFDSIEANNTSAFNCRQATGSGSWSQHAYGLAVDINPCENPYVSADGTISHKDCVKYKDRSLDVPGLIHRGDKTVQAFADIGWGWGGNWTGVKDYQHFSSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVQ1</accession>
    <name>A0A1H6CVQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76877">
        <property type="protein sequence ID" value="SEG76877"/>
        <property type="gene ID" value="SAMN04489712_111219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="29802" checksum="586CC4A671F445F3" modified="2017-01-18" version="1">MNVHVDDPVRLGESRLPGGRLLGWAEWGPPGGIPVLLSPGAATSRWLGFGGGALDRLGVRLISVDRPGLGASTPAPGRTFADHAADIRELAALLGLGRPAMVANSQGTPFALACAAEGVVAGLAVVSGADEVAAPEFADALPGDLRGLVETVTSDPVRAEGVFAGFGPQAMWDMVMGGSPQSDLAVYQDPAFASAYRRALEEGFAQGPQGYARDTVLAMGRWPFDLASIAVPVDLWYGEEDTSHSPDNGATLATRIPGATRHVIPGIGGAVLWTHAEPILRTLLDRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYZ7</accession>
    <name>A0A1H6CYZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78359">
        <property type="protein sequence ID" value="SEG78359"/>
        <property type="gene ID" value="SAMN04489712_11267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="32726" checksum="B055C5F3646EF94E" modified="2017-01-18" version="1">MTTAHGTGPQAGWAGVDLSAAASFMAAHARTLDRRRFQLLTGDTDPSAVLAALDGYRNPDGGYGWGLEPDLRSPESQPGGALHAFETYADVTPARSPHSGALCDWLASVSLPDGGLPFALPVTDDAGCAPWWAQADPTVSSLHITSAIAGMAHRVAAHDPAVAEHSWLARATRYCLEVIEAIDTAPHALELLYTLQFLDAVHDTHPEAAPLLARLGEYLPDDGLLHVEGGTEDEMMRPLDFAPLPGRPVRSLFTPDAIAAELRRLAEGQQADGGWTVEYASFSPAARLEWRGYITVRSLGILRHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZH5</accession>
    <name>A0A1H6CZH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbaB/EbfC DNA-binding family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78549">
        <property type="protein sequence ID" value="SEG78549"/>
        <property type="gene ID" value="SAMN04489712_11290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="26725" checksum="2A4BCB3603F4A814" modified="2017-01-18" version="1">MSTEGPVGDDAPVRGSGADAEGRVRAVAERARVKSLEIHPRVMGLPVDELAECSRTAINAALDDLRSKLPFDAAPGMDAGAVTRYLDEVQTQGLQTMEALTSSLSEAMSLLRESVTFQGGPAPHGLHGLQGLLAESQRMLASVAVPPHELPELEGTGEAAQGLVRAVAEPGGRIRSLVVEKRAMRSPSQELAGHLVTAVNAALDDLQSRSEREAGSAGIDQEEISRLRESSMQQSADFMRSLADMINSIQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZK0</accession>
    <name>A0A1H6CZK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78589">
        <property type="protein sequence ID" value="SEG78589"/>
        <property type="gene ID" value="SAMN04489712_11296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="322" mass="34133" checksum="C8EB4564331378B5" modified="2017-01-18" version="1">MARTRPDITVPDLSGKLAVVTGASDGVGLGLAARLAAAGAEVVMPVRNRRKGEAAIAKIKQQYPEATLSLRDLDLSSLGSVAALGATLLGENRPIHILINNAGVMTPPTRQTTTDGFELQFGSNHLGHFALVAHLLPLLRAGRARVTSQISIAANENAINWDDLNWERSYHGRRAYSQSKIAFGLFGLELDRRSQAGGWGITSNLSHPGIAPTSLLAARPEVGRARDTTAVRVIRTLARRGILAGTVETALLPALMAATSPDARGARLYGPSGLGHLSGAPAEQAVYSRLRSEDDAKRIWQISENLTHTSFPADEGVRPGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0G5</accession>
    <name>A0A1H6D0G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78762">
        <property type="protein sequence ID" value="SEG78762"/>
        <property type="gene ID" value="SAMN04489712_112122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="545" mass="58537" checksum="3C164E601DBF5542" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1F3</accession>
    <name>A0A1H6D1F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall-associated hydrolase, NlpC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_112160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79047">
        <property type="protein sequence ID" value="SEG79047"/>
        <property type="gene ID" value="SAMN04489712_112160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295423" evidence="3">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="59"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG79047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="179" mass="18857" checksum="0FBADC31EACC2F2C" modified="2017-01-18" version="1">MLGGIALSATAALTAAALPATPATPAAAATTAPATVTAPATQPVAATTSTTKTKQQKQKERAAKAVKYAYKQIGDPYRYGATGPGSWDCSGLAGGSWRKAGVKLPRTTTQIYAHVKRKVRYSKMKPGDLIFFYSGRSHMGIYVGKGYMIHAPSSGKRVQKVKLSSYYKGQFNGAVRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2G0</accession>
    <name>A0A1H6D2G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YiaA/B two helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_112161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79053">
        <property type="protein sequence ID" value="SEG79053"/>
        <property type="gene ID" value="SAMN04489712_112161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008024">
        <property type="entry name" value="YiaAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05360">
        <property type="entry name" value="YiaAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="YiaAB" evidence="3">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG79053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="100" mass="10574" checksum="20370439D0F246CA" modified="2017-01-18" version="1">MNALFQLKGTTAFFVQSALSFTVATAGVGLGIAFMPAPTWIRAFLALGMLYVITSTFTLAKVIRDRQEAAAMADVRDRPSPPGPLPPNAPYVDASGGSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4X4</accession>
    <name>A0A1H6D4X4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynA</name>
        <name evidence="2" type="ORF">SAMN04489712_11313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80104">
        <property type="protein sequence ID" value="SEG80104"/>
        <property type="gene ID" value="SAMN04489712_11313"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="30023" checksum="072B34FF549F2553" modified="2017-01-18" version="1">MDTGPQEHASLTYSSYLALEDVLAAQHPRSDEHDEMLFIVIHQVYELWFKQLLHELAYLQRRLEAGDSAHSLRTLDRVLSVLKVVVAQIDVLETMLPSRFAGFRSRLEAASGFQSAQFRELEAVLGRRDERAFRHYPVGGAARERIEAAMSRPSLYDSFLAYLRVHGYPVPRRPDVRRPPEPDPRVQDVLLKVYTDDGAPASVCERLVDLDEGLQEWRYRHVKMVERTIGDKSGTGGSSGAGYLRTTLFAPMFPDLWEVRKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7S8</accession>
    <name>A0A1H6D7S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81349">
        <property type="protein sequence ID" value="SEG81349"/>
        <property type="gene ID" value="SAMN04489712_11432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="30185" checksum="56C113D642ADD348" modified="2017-01-18" version="1">MGHDYDRVTDLNHTNPTRRRGALVTHPAQPWTPTVHAFLRHLEAEGFEAAPRVAGAGFDEAGDETLTWLEGTIFARSVWPDAERSMHEVGALLRRLHQVSRTFTPPPDARWMPWTLHTDAAEALISHGNIAPWHVVFHQDRPTGLIGWEYTGPVDPMDEVAVTAFYCAQLFDDDVAEQIGLPDAAARAQWFAAFLDGYGLPRHRRTDLIDRILYFVIKDNGWYSRVQGFTPHHTHTEGLWTLAWQSRAALWTLEHRELLTRTATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D849</accession>
    <name>A0A1H6D849_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81480">
        <property type="protein sequence ID" value="SEG81480"/>
        <property type="gene ID" value="SAMN04489712_11466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="100" mass="11353" checksum="73F2FC0851CF4445" modified="2017-01-18" version="1">MTTTSQQRTHGNHPHVHGEACGHVAFPHDGHVDYLHDGHIHHVHDGHVYECAETGHVIHEQHKHQHGHGCGHVAVPHDDHVDYLHDGHRHALHDGHWDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8X7</accession>
    <name>A0A1H6D8X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted PurR-regulated permease PerM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_114113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81669">
        <property type="protein sequence ID" value="SEG81669"/>
        <property type="gene ID" value="SAMN04489712_114113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG81669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="38105" checksum="5E6DB410577A387E" modified="2017-01-18" version="1">MGPTAERMPPWLPRAFALAAAIAAASWAGLWLLARLKGLLILLLLSMFLALAIEPAVNRLAGHGWRRGPATGAILALILAATGLFFGVLGSLLVAQAGALVRNIPGYSDTVIGWVNHTFGTNLSQTTLLDRLPDLAGELGRHLSQVAGNVWGIGATAVGLLFQGLAVLLFTYYLTAQGPRFRRQVCAVLPPHRQREVLRAWQIALDKTGGYLYSRALLAVVSAAAHAVTLTLLDVPSALALAVWAGAVSQFIPTVGTYLAGVLPVLVALAADPGTALWVLAFTIAYQQVENYVLQPRITARALAMHPAVAFGLVLAGVAVLGPVGALLALPLGASLQVLLSACVRRYTVEEHPLTTEAPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D903</accession>
    <name>A0A1H6D903_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_114107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81648">
        <property type="protein sequence ID" value="SEG81648"/>
        <property type="gene ID" value="SAMN04489712_114107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG81648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="19044" checksum="634DD3D6746EDADD" modified="2017-01-18" version="1">MEIWPQATVQQCVVHLIRSLLRYASKAHWSRLTKDLRRIYTAPTETAAEQRFAEFEAEWGDRYPAVIRLWREAWPTFTPFLAFPAEIRRVIYTTNAIESLGARFRQAARRRGHFPTEQAALKVLYLVIRQPLKNRPNVTGRTPGWKTALNTLALYYGDRITLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAN3</accession>
    <name>A0A1H6DAN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SAMN04489712_11477</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81526">
        <property type="protein sequence ID" value="SEG81526"/>
        <property type="gene ID" value="SAMN04489712_11477"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="7 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="10"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="17">
        <location>
            <begin position="327"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="15">
        <location>
            <begin position="423"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="14">
        <location>
            <begin position="561"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="13">
        <location>
            <begin position="633"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SEG81526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="846" mass="89643" checksum="CAACA0B1DFD0FC25" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DB58</accession>
    <name>A0A1H6DB58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82500">
        <property type="protein sequence ID" value="SEG82500"/>
        <property type="gene ID" value="SAMN04489712_11535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="36936" checksum="1E4DAA3C5F019274" modified="2017-01-18" version="1">MRARSVLTEASRNLATGTTRAALFGLALAVLAGGLAIADARSVMDLRRRAGDFVASGATVQVLVARNTTDAASCEGLSRVTGVRAAGALREADPVVLRAMSANPIPAFAVTPGLVRLLGGDPGARAGAWLPEELARTLRVTAGSTLATTAGTLTVAGTYAHPDDGRDGRLAYAVLLPRLPQGIFDECWVDTRPVSPSAKRTMYAAVKVDGESTEPVNMEQLNAGMGLEFDGAAQFSARATRHALPACAVAGFVLGFAAVRRRRLELAGALHIGMPARAIMTMTLAETAAWALAAFALAAFALVAVVVTGTPVDGRQIYLIDVRGPAAAAVAALAGAACAALTIRERQLFRYFKDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBJ5</accession>
    <name>A0A1H6DBJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82658">
        <property type="protein sequence ID" value="SEG82658"/>
        <property type="gene ID" value="SAMN04489712_11558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295801" evidence="1">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="88" mass="9243" checksum="F099B03BE878C63D" modified="2017-01-18" version="1">MLKRLATAGALTTVVGGMLVSAAPAMADNGAYSLDQHGSRQGASENRCTNYGENRTLVRSLEILEFHNVVFGGDGRQVGVTTNTCVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF01</accession>
    <name>A0A1H6DF01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate lyase subunit beta / citryl-CoA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83811">
        <property type="protein sequence ID" value="SEG83811"/>
        <property type="gene ID" value="SAMN04489712_11672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="11"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG83811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="297" mass="31312" checksum="B6DCA3C2ED4BAD7A" modified="2017-01-18" version="1">MTGTGAVPGARSWLFAPGDSERKMSKAANGTADIVLLDLEDAVAPDEKPRARKMVAAFLASRPPADRGRLWVRINPLDGPHALADLAAVIPARPGGIMLPKSRGRQDVDVLGHYLSALEVAAGIERGTTQVIVLVTETAEGMFTTGSYQGAPRMVAMSWGAEDLADAVGAGENRGPDGSYGFTYELARSLCLLGAAAAGVAAVETIHGDFRDLEGLRRRAEKVRRDGYRGMLAIHPDQVEVINAAFTPTEEELAAAQKIVDLFAAHPGAGAIGHKGVMLDRPHLARAQALLASGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIH5</accession>
    <name>A0A1H6DIH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_117113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85014">
        <property type="protein sequence ID" value="SEG85014"/>
        <property type="gene ID" value="SAMN04489712_117113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG85014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="236" mass="24903" checksum="9D45575876E9BFB7" modified="2017-01-18" version="1">MGSLQVSGVTVAFGGHRALDDVAMTAEPGRVTGLIGPNGAGKSTLFDVVSGLRRPSSGRVVLDGRDVTRLGPARRARHGLARTFQRLELFGRLSVGDNLRVAAELGPERRRADHVVTEILDRLGLAHLADTPSDSLSTGVARLVEVGRAMAARPKLLLLDEPAAGQDGEETERFAALLRSLAGDGTAVVLVEHDMGLVMNVCDEVHVLNLGKIIASGPPEVIRRDETVLAAYLGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL06</accession>
    <name>A0A1H6DL06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85523">
        <property type="protein sequence ID" value="SEG85523"/>
        <property type="gene ID" value="SAMN04489712_11823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="14810" checksum="BF2448D4EE067728" modified="2017-01-18" version="1">MSSEEKRSWIYVVVSAGVAAVYFVIVLSKVPGADVARIAYVRPMLIAIGAGIGLGIVATIAAAIASPREAGRADERDRQIHRLGEYVGFYVMSIAAIVPLALAMAEAAHFWIANALYLAFVLAALASSIAKIVLYRRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL42</accession>
    <name>A0A1H6DL42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysophospholipase L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_118104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85904">
        <property type="protein sequence ID" value="SEG85904"/>
        <property type="gene ID" value="SAMN04489712_118104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296005" evidence="2">
        <location>
            <begin position="24"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="47"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG85904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="29699" checksum="574D609D50A07B61" modified="2017-01-18" version="1">MPRLVWCAFAALLLLCSCTSSQASEPRRTARPKTEPARPHVPVVFMLGDSYTAGITSVPPEQTYAGETARRLGWQVVIAGYAGTGFVSRGRIGKDFAALYEAQLAWRPAPDMVVVSGGHNDVYYPYRVGPAANRLLTTIKSRWPKTHVVLVGPLWGGDPPPQALRVRDTLRGTAATLQVPFIDPLAERWITGNIHRRTGNARRFILRDGTHPTAAGNRHIAERLVAGLRARGLERPALGKPARRPAQQTPGAGRTANAEDRDDLKELQRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLE5</accession>
    <name>A0A1H6DLE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_11855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85663">
        <property type="protein sequence ID" value="SEG85663"/>
        <property type="gene ID" value="SAMN04489712_11855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006293">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01389">
        <property type="entry name" value="recQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="34"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="223"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="9">
        <location>
            <begin position="538"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG85663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="616" mass="67844" checksum="884532A2B45AE12B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLM7</accession>
    <name>A0A1H6DLM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase (NDP forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86192">
        <property type="protein sequence ID" value="SEG86192"/>
        <property type="gene ID" value="SAMN04489712_11913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="654" mass="66921" checksum="EEE6E2C2D93E54C6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNV0</accession>
    <name>A0A1H6DNV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86443">
        <property type="protein sequence ID" value="SEG86443"/>
        <property type="gene ID" value="SAMN04489712_11985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="19281" checksum="6D3A4BC7848456E7" modified="2017-01-18" version="1">MALAVESEIESEQAPYDLLQLTRLRRGGTVRRPTARARGRAGGLATHTRRRTASGAPLIELQNTRFELAECATLAHAGRVFADSCVERHLRGELDAATAAMTKWWLTDVQCQVIDRCLQLFGGYGYMREYPIARMYADARAQRIYGGTNELMKEIITRSLSRAAGRAPIGWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNY7</accession>
    <name>A0A1H6DNY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86901">
        <property type="protein sequence ID" value="SEG86901"/>
        <property type="gene ID" value="SAMN04489712_12030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="80"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG86901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="29964" checksum="C4F641AD2D00009E" modified="2017-01-18" version="1">MTTTTAPAAAKAPARRRVPRKGLGLRIYTWAVIAWLVLPIAVMILFGFNDTSSKFNFEWEGFTLKWYAQLFDREDLTTALINSITIALASTVITTVLGTLVGLALGRYSFRGKGVSNLVLFAAISSPELVMGASLLSMFVTLNTPRGYATILVSHVMFSIAFVAMTVRARAVGLDPSIEEAARDLGAGPWTTFRLVTLPLIMPGVISGALLAFALSIDDFIITNFTSGSTVTFPLWVWGSTRTGTPPQVNVMGTLLFAAGVLIAVLNMVASRRRARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSU9</accession>
    <name>A0A1H6DSU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-methylhydantoinase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87796">
        <property type="protein sequence ID" value="SEG87796"/>
        <property type="gene ID" value="SAMN04489712_1213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="221"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="709" mass="75445" checksum="FA60A41D831D906F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU45</accession>
    <name>A0A1H6DU45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88115">
        <property type="protein sequence ID" value="SEG88115"/>
        <property type="gene ID" value="SAMN04489712_12179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="30" mass="3013" checksum="4C1ADDD8B7D0F2AA" modified="2017-01-18" version="1">MSGPDMNGPFDPNGGTPAVTVRRALGQGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUL2</accession>
    <name>A0A1H6DUL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88734">
        <property type="protein sequence ID" value="SEG88734"/>
        <property type="gene ID" value="SAMN04489712_12268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG88734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="21749" checksum="055A66DECA6BEF1A" modified="2017-01-18" version="1">MIRLLIVDDHPIVRGGLRAAFETEPDIEVAGEAATGREGIERAAALGVDVVLMDLRMPEMDGVAAITALRSSHPGIKTLVLTTFDGDVDVLPAIEAGATGYLLKDAPTEELLRAVRAAAAGEPVLSPSVASRLMGQVRRPVKAALTDREIQVLTLVAGGASNRQAAAKLFISEASIKTHLLHIYDKLGVRDRAAAVGEAYRRGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVJ9</accession>
    <name>A0A1H6DVJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplT</name>
        <name evidence="8" type="ORF">SAMN04489712_12379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89377">
        <property type="protein sequence ID" value="SEG89377"/>
        <property type="gene ID" value="SAMN04489712_12379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG89377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="125" mass="14524" checksum="626952B68071009C" modified="2017-01-18" version="1">MARVKRAVNAAKKRRVVLERASGYRGQRSRLYRKAKEQMLHSMTYAYRDRKDRKGQFRRLWIQRINAAARANGMTYNRFIQGLKAAELEVDRRMLAELAVNEPEVFKTLVELAKESLPAQDAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX53</accession>
    <name>A0A1H6DX53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">SAMN04489712_12462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89779">
        <property type="protein sequence ID" value="SEG89779"/>
        <property type="gene ID" value="SAMN04489712_12462"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="27"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG89779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="430" mass="45672" checksum="8D017F3DF147182C" modified="2017-01-18" version="1">MSMGHEVRYRVRGGHKLQGTVFIQGAKNAVLPMIGASLMASKGRTVLRNVPIIEDVRRAVELAQAVGAKAELHEAERTLVIDASTLTSPVLPAEIAARFRGSFLFVPALLHRLGEAVIEGVGGCNLGSRNLDFHYNGFKRMGATVTEQVADDGAGVIHIKAGDLRGATLYCDTPSHTGTENLVMAGALATGTTLIKNCALEPEVLDNIEFLQRMGARISGGGTGFITVEGVDELTAVEHTVMPDRIDAGVFVMAAAITGGEVSLVGASLEHLGVAADKLEQMGVEFHQQGAVLQVRRERPLRPINVITDEYPGFATDLQSPIMAVSCLADGPSYIYERIFDGRFKLVDELTKMGADIQVDGNRAKVLGPTPLHGAEVVAHDLRAGSALVLAGLGAEGETTITQAYYLDRGHAHIAERLSQLGADITREVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ72</accession>
    <name>A0A1H6DZ72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative spermidine/putrescine transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90113">
        <property type="protein sequence ID" value="SEG90113"/>
        <property type="gene ID" value="SAMN04489712_12542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296383" evidence="1">
        <location>
            <begin position="30"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="353" mass="38341" checksum="C20F9D4E70A12785" modified="2017-01-18" version="1">MKTTKLLAIASVAGLAVTLSSCGGSGSGASESSLTVTMWGGAAQKAHVDSYFTPWAKTKGVTIKQDSPTDYAKIKAQVEAGKVTSGPTEVEPNFANTACEAGLLEKLPQDILDKAKATGVAEDQIGPCAIPILQYSFTIAYNSKTFSGAHPTTWAEFFDTKRFPGKRGFWKYATGGMFEAALLADGVTPDQLYPLDIDRAFKKLDSIKSDIVFFDTGDQMTQMLASGEAPLVQAWSGRIFQAQQEGEKVANEWNDNLVSYDQIVVPKGYPNKDLAFDWMRWFLDNPKAQAADADASIYGPASDKALEFVSENVRKELPGFPANAERSAGLVDYGYWAENYDSVTERLNAWIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0B6</accession>
    <name>A0A1H6E0B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90901">
        <property type="protein sequence ID" value="SEG90901"/>
        <property type="gene ID" value="SAMN04489712_12772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296413" evidence="4">
        <location>
            <begin position="38"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG90901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="502" mass="54878" checksum="EE00F0DBD02F178B" modified="2017-01-18" version="1">MNPERPPAGPRVPRDSRRRFLLTAAAATVVPAGAAVAAWPALGSGRTTASPAPSPARRRRRSGRPNFVVVVADDLGYGELGGYGQTQIRTPRLDRLAAEGVRFTDFYAGAPVCAPSRCSLLTGRHIGRARVRTNPKGPDSSLTDADLTFGKVLQEAGYRTGLFGKWGFGPAEPDQPSHPHAQGFGEFFGYLTHGEAHRYFPPALWDGRRSLPLPANRPRARNVYAPELIVRRGLDFVDRHRDEPFLLVLTPPLPHAPSIAPSPFPYRARTWARPDRAHAAQVTLLDSYVGRLVDRLTSLGLADDTVVLFTSDNGPHEEGGFDPDFFHASGGLRGYKRSLYEGGIRVPLIAWSPGLLGRGRGRVSSHPSAMWDLFPTITDLAGLGPPDEVDGRSLRGLLTGTGGPPRRDYLYWARPNGAKPTPRVAAAEGEHAGRAAAAVRFGRWKAVGFAPGRHYFDPDDRWSYELYDLWTDPGERTDVAASRPEILDQAIRYLHEAWVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E108</accession>
    <name>A0A1H6E108_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90853">
        <property type="protein sequence ID" value="SEG90853"/>
        <property type="gene ID" value="SAMN04489712_12758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="8"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="28042" checksum="BC41EF494BBE13E4" modified="2017-01-18" version="1">MIFDADRPVVIGHRGAGSGEVLLPGEAEAVTENTVESILGAVRAGATWVEIDVTRTADDELVLRHDPTGADGAFLIDRTAAESGLPRLVDVFDALPPEVALDVDVKTVLEDAVDPPARRTGALLAPLLAAESRRRPLMVTSFDPSLLLGLREELDGVPLGLLTWLRFPLWHAIAAASGLGLDAVGVHTGSCGFDSQDTRLRPLDHNVDVAHKAGLEVLAWCPAPADSPRYAAAGVDALVVNDVPGAISALTSSGEPDVPDPAEDVVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1N9</accession>
    <name>A0A1H6E1N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91259">
        <property type="protein sequence ID" value="SEG91259"/>
        <property type="gene ID" value="SAMN04489712_12874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="43"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="212"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="462"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="554" mass="59607" checksum="63D7F60538ED1C6F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2T2</accession>
    <name>A0A1H6E2T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91424">
        <property type="protein sequence ID" value="SEG91424"/>
        <property type="gene ID" value="SAMN04489712_12913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="115" mass="12650" checksum="CFABCA135C7CE04E" modified="2017-01-18" version="1">MVKTPKLGITTPADAVAVIPYLLGFHPDNSLGVLCWNTHSNFAARLDLVGRQHYSDLLMQVLGMVSCRQASPSYTLAWLLQQCLDHAVPPKVIRERFSLTPDALAQAWGDSTETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2W6</accession>
    <name>A0A1H6E2W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91454">
        <property type="protein sequence ID" value="SEG91454"/>
        <property type="gene ID" value="SAMN04489712_12922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG91454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="381" mass="41515" checksum="F7D0723B8E0985E3" modified="2017-01-18" version="1">MYVSSWRSDGLDLLRDTARAFFAAEAVPHRERWARQRHVDRGFWTKAGKAGLLCCSVPEQYGGAGADFDADLVVFEEQARIGELGWGNMVHSGIVAHYLLAYGTEEQKRRWLPGMASGELIGAIAMTEPGTGSDLASVATRAVRDGDGYVLSGAKTFITNGSTADLVIVVCSTDPAAGHRGISLLVVDTRDCAGFRRGRVLDKVGQHSADTCELFFEQVRVSAANLLGEEGSGFSYLMRQLPQERLIIAVAAVTATEAAVAETIAYTRQRTAFGAPLIELQNTRFELAECATLAHAGRVFADSCVERHLRGGLDAATAAMAKWWLTDVQCQVIDRCLQLFGGYGYMREYPIARMYADARAQRIYGGTNEIMKEIIGRSLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3F0</accession>
    <name>A0A1H6E3F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91405">
        <property type="protein sequence ID" value="SEG91405"/>
        <property type="gene ID" value="SAMN04489712_1297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTRA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="53" mass="5929" checksum="2A8DC192F8B0D216" modified="2017-01-18" version="1">MPTPEEAETLHITAGVPVLTITRRMLSGDRPYEVCRDIVIPADRITLDYSSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E416</accession>
    <name>A0A1H6E416_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein TerZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92382">
        <property type="protein sequence ID" value="SEG92382"/>
        <property type="gene ID" value="SAMN04489712_13335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="189" mass="20287" checksum="B327FD9D2A596F6C" modified="2017-01-18" version="1">MSVSLQKGQRISLEKPGGVLSMVRMGLGWDAVKKKGFFGSREREIDLDASCLLFADGRLADVIYFGKLTSDDGSVRHTGDNLTGAGDGDDESVIVDLGRLPVHVTSLVFTVSSFNGQTFNEVENAFCRLVDESNGAEMARYTLTGGGAHTGMVMAKLYRHGNGWKMNAIGEPAQGRTFQDMLPAIAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E459</accession>
    <name>A0A1H6E459_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92367">
        <property type="protein sequence ID" value="SEG92367"/>
        <property type="gene ID" value="SAMN04489712_13329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="661" mass="70722" checksum="B0BC49702A3C10D6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E630</accession>
    <name>A0A1H6E630_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92721">
        <property type="protein sequence ID" value="SEG92721"/>
        <property type="gene ID" value="SAMN04489712_13511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="23093" checksum="A34725CB6C56C74B" modified="2017-01-18" version="1">MKSPVRRTLTERRSDELRLSVAMAAQELFVLDGGTGPTVESICHRAGISPRTFYRHFAVKEDVVVPLFRRAAELIIEALQAAPAAGDVVTALVRAFSWDVFEDARPGEPWRRFLSVIMDSPEYRLRWHAIDDLLTDPIAGFLRSRRLVGDDPFDGVLHAGLVLHSVRLAYQHWIRTDASRDLDKLLEQALTTVMSSWDGSDQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6D2</accession>
    <name>A0A1H6E6D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92526">
        <property type="protein sequence ID" value="SEG92526"/>
        <property type="gene ID" value="SAMN04489712_13424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="491" mass="51270" checksum="8051F3CDDE0520FC" modified="2017-01-18" version="1">MPNSDEPGVNGAELVAHSLDAGGQGDADTAVARVGDPVTVWPCANCGRPVPQPVGGSRTIRYCQDNDGVCEREARGRRERGRDAPGLTGQVAWTWELVERLEKMADGLAESLTSELSVAGVERRVAEIRAEAARDLAVAQSERDASERQAEEARHEAATARARMQAAEEEARRARQEAKLATAKRDAAQQAWEEAHQVAQQAVAARQAAESERDRVTARENELLSALESSRAELVALHAKLAETEAAAEAQRAEAAVTRQGAEDLRTAMREAETQRQQAVQAAAKAEEERTAARRAQAEAEAEAARAAARCGEALGERDAALAQTQQALAERDRLTARMAEQAGQSQQLAQTVAELQAALAALAAERDAARAEADRARRQIDQLTQNVSSGVLPGVPVAGSAAQAPAAPAPGAASGGPASVPGGPAPRHEAVPSPAPIGGGLYEAPATGYNAASGSFTPASSPYGPPAPAGQDQNGRSGEADREDPLFARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E843</accession>
    <name>A0A1H6E843_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93892">
        <property type="protein sequence ID" value="SEG93892"/>
        <property type="gene ID" value="SAMN04489712_14123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="48"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="27700" checksum="1F3D01E1232740C3" modified="2017-01-18" version="1">MSEEIAAHYDRLADRYDENWTHSAEFIAWMTSCILGRLDPQPGNRVADIGCGTGLFTRGLVESAGQVACVDPSGAMLERLPEGEGYVPVEASAEDVAEGRVALPYGRLDAILVKEAIHHVRDRARVLAGLAGMLAPGGRVLVVMLPTTIDYPLFDRALRAFEKHQPDPEDIAGHLERAGLQVRLSYESFPLSFSKERYLRMVRNRYMSLLSMFDDAELEAGVAEIDRRHPEEILQFPDRFAFVLGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E848</accession>
    <name>A0A1H6E848_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93116">
        <property type="protein sequence ID" value="SEG93116"/>
        <property type="gene ID" value="SAMN04489712_13717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="15637" checksum="200ED0198746D2A2" modified="2017-01-18" version="1">MGKAPSPGRKAGAVPPRIREVMSAAPIMVPLETTLAEVARLMRDRGIGDVLVTSAGRLCGIVTDRDIVVRAVADGLSAVVTTVGDICSAGPATVRPDDDTAAAAALMRRHAVRRLPVVEGHRTVGIVSIGDLAIVHGDDPVLADISKAPPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E927</accession>
    <name>A0A1H6E927_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93761">
        <property type="protein sequence ID" value="SEG93761"/>
        <property type="gene ID" value="SAMN04489712_14031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="25360" checksum="BBE0DF24FE830DBC" modified="2017-01-18" version="1">MTREHAVVTGGSSGIGLAVVRRLMKRGLAVTVLDMQPPPDDGPQAFQVDVTREPDVRAALAEAARTAGTPTRLVTCHGIRGEFKPALELNLDAYRRVLDVHLVGTLVTARSLVAGLLADDATNGGSIVTISSTTAYGGWANQADYGVAKAAVEQLTQNLAIEWAPLGVRVNAVAPGHTLTPMVQEMVDQGYDLSATEARMPLGRLCTPDEMAAAIEFLLLDATFSTGVRMPVDGGWTAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAS9</accession>
    <name>A0A1H6EAS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neutral metalloproteinase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_1528</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000052">
        <property type="protein sequence ID" value="SEG94832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94832">
        <property type="protein sequence ID" value="SEG94832"/>
        <property type="gene ID" value="SAMN04489712_1528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023125212" description="Neutral metalloproteinase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="12">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="10">
        <location>
            <begin position="225"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="11">
        <location>
            <begin position="361"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG94832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="696" mass="71505" checksum="9BC3F105B4C99AB9" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAT2</accession>
    <name>A0A1H6EAT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-directed DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG94024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94024">
        <property type="protein sequence ID" value="SEG94024"/>
        <property type="gene ID" value="SAMN04489712_14229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="490" mass="55255" checksum="987E8909C0884249" modified="2017-01-18" version="1">MPKDALPNGSAQGPAPVGSWSRVSEMQAKLHRWAAADPGRRFDDLFNFVHDPATLIVAFDRVADNRGARTPGIDGLTVADVEEQIGVPGFLNDLRTCLKDGSFRPLPVRECRIPKPGGSGKVRALGIPTVRDRVVQAALELVLEPIFEADFEPVSYGFRPGQRAQDAIAEIHHFGTRGYRWVLDADIEACFDRIDHTALMDRVRLRVKDKRVLSLVKAFLKAGILTELGGSRSTTTGTPQGGILSPLLANIALSVLDEHLMGPWKPGGSMSSEGKRGYRRRRGLPTWRLVRYADDFVVLVHGTGNDTQAVREDVARVLEPLGLRLSPAKTQIVHLSDGFDFLGFRIQWRRKRGTDKWHVYTFIADRPIRSLKAKIRALTRRKSQQDLGSVLIRLNQIMRGWANYFKHAVAKDRFSALHQFVWWRLIRMLQLQHRWNWKDVRRHLTTPTGRWLPITATDGTELFNIAKVTVTRYRWRSNKIPNPGGISSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5RZK0</accession>
    <name>A0A1H5RZK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43792">
        <property type="protein sequence ID" value="SEF43792"/>
        <property type="gene ID" value="SAMN04489712_10120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF43792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="529" mass="55414" checksum="C96C082B102E5063" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S3R4</accession>
    <name>A0A1H5S3R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45293">
        <property type="protein sequence ID" value="SEF45293"/>
        <property type="gene ID" value="SAMN04489712_10170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
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        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF45293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="12803" checksum="6FB824D45FAC536E" modified="2017-01-18" version="1">MTVESTQGTSEQVTGVILTDAAASKAKALLEQEGRDDLALRVAVQPGGCSGLIYQLFFDEREMDGDQVQDFEGLAVRVDRMSAPYLTGATIDFVDTIEKQGFTIDNPNATGSCACGDSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S4H9</accession>
    <name>A0A1H5S4H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipoprotein-anchoring transpeptidase ErfK/SrfK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45526">
        <property type="protein sequence ID" value="SEF45526"/>
        <property type="gene ID" value="SAMN04489712_10177"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Big_10" evidence="5">
        <location>
            <begin position="34"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="220"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF45526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="44222" checksum="EF2996A565426923" modified="2017-01-18" version="1">MGVTMAAVAAGCTEDERVVSKPVGLSIEPHNGSAQVRPDTPILVRAAGGTLQNVTVRARGADVAGLTSGDRSQWRSRWTLAPDTRYDVVATALGKDGRTRTVSSAFTTQKVKRAVTVSMEAPNQGETVGVGMPIILRFDREVTDRAAVERALEVRSSKRVEGAWRWLEDGSLVFRTRRHWPTHTDVRVIAHLNGVRALRDGYATQDLDVKFRIGEEHATVADAKTHRMVVYRNGKQIRDFPVSMGRGGVHKYITTSGNHLTMDKGNPVIMDSSTLGCGPGCPGYYRMAVYWSVRISNSGEYAHAAPWSVGSQGNSNVTHGCVNMHPDAAQWFYKFSYRGDPFKVVGTSRELEPGNGWGYWQMDWEKWAEGSALKQTLWVGPEGSVPVQAKRLQAPRPTTSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S639</accession>
    <name>A0A1H5S639_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_10194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46076">
        <property type="protein sequence ID" value="SEF46076"/>
        <property type="gene ID" value="SAMN04489712_10194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="9">
        <location>
            <begin position="17"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF46076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="551" mass="61261" checksum="8EF926CE4BC0B017" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S9R7</accession>
    <name>A0A1H5S9R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-D-arabinoheptulosonate-7-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47363">
        <property type="protein sequence ID" value="SEF47363"/>
        <property type="gene ID" value="SAMN04489712_101129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="87"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF47363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="347" mass="36648" checksum="BF36F513EED66621" modified="2017-01-18" version="1">MVVVMGPEATEADIAAVVSIVETAGGEAFVSRGVARTIVGLVGDVEQFGSLNLRGMDGVRDVIRISVPYKLVSRENHAERSVVRVGGVPIGPGTMTLIAGPCAVETPEQTLQAAQMAKAAGATLLRGGAFKPRTSPYAFQGLGEQGLRILADVREETGLPVVTEVVDAHDVELVASYADMLQIGTRNAQNFALLQAAGESGKPVMLKRGMSGTIEEWLMAAEYVAQRGNLDIVLCERGIRTFEQATRNTLDISAVPVAQRLSHLPVIVDPSHSGGRRDLVLPLTRAAIAVGADGVIIDVHPHPETALCDGPQALVDGDLRELARLVRELPPVFGRALTQSPDPLAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJX5</accession>
    <name>A0A1H5SJX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50896">
        <property type="protein sequence ID" value="SEF50896"/>
        <property type="gene ID" value="SAMN04489712_101244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF50896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="220" mass="23447" checksum="2282B761F55BE5FF" modified="2017-01-18" version="1">MIDLQRDGDVFVLRLDEGENRFSPGFLDAVQAALDTVEKAEGPRALVTVGAGRFYSNGLDLDWLGAHSDQFESYLGRVHEMFARLLALPMPTVAAINGHAFAGGGMLALTHDFAVMRTGRGYFCLPEVDLGMSFTPGMNALIRARLPRVTAHEAMITGRRYTAEEALAAGIVAQAAPEEEVLPAAVARAAGLAGKDGRVVARIRTDLYGPALAALRGPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SXQ3</accession>
    <name>A0A1H5SXQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">SAMN04489712_101381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54567">
        <property type="protein sequence ID" value="SEF54567"/>
        <property type="gene ID" value="SAMN04489712_101381"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="13"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="311"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="197"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF54567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="560" mass="60704" checksum="72E9D293D5A69180" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T9M8</accession>
    <name>A0A1H5T9M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58791">
        <property type="protein sequence ID" value="SEF58791"/>
        <property type="gene ID" value="SAMN04489712_101514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF58791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="28523" checksum="9F9F30F007962B5B" modified="2017-01-18" version="1">MRTIPRRQEPALRGASSEGGADLLPSQNLSRMSSGEQVRLYVRRLIFDGVLRQGQRVPQDAIAQTLGVSRIPVREALIALEREGWMTIVPHRGVFVNALDESSVHDHYELYGLFYGFAVRRAVERRGPELAERLAPIAKQIADTKDVERLHELTMQFHKLVVESAQSPRLRSMLRQMTGIVPGNFFDLVPGADAVERRGTAAIVRAIRKGDAAQAEEEYAKMLRKQGDLVAALFRKRGMFEQEQQPEQEPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U163</accession>
    <name>A0A1H5U163_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, LacI/PurR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67991">
        <property type="protein sequence ID" value="SEF67991"/>
        <property type="gene ID" value="SAMN04489712_101800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF67991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="37358" checksum="C6B334F732D0B10E" modified="2017-01-18" version="1">MEEPKRPGERRPVVMEDVAERAGVSAMTVSRVLNSPEKVRPATRARVLAAVKELDYRPNAAARVLATGRSGVLGVVSFDTTLYGPASTLYGIERAAREHDYMISIVSLGVLNRKTIGEGVDRLRSQNVDGIIIVAPHESAAEGLRDLPPDLAIVVVGAADDLPFPLASVDQYGGAVRATRHLLSLGHGTVWHLSGPADWVDAHARVEGWRAALLAEEREVPEMIMGDWSAQSGYQLGRQIIRDPEVTAIFAANDAMALGLLRALREAGRRVPEEVSVVGFDDVPEAPYFSPPLTTVRQNFGEVGFRAFRLMLDRIDAPDAEAMPHRRVVEPELVVRESTGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UZ94</accession>
    <name>A0A1H5UZ94_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose alpha-D-glucosyltransferase</fullName>
            <ecNumber evidence="3">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79781">
        <property type="protein sequence ID" value="SEF79781"/>
        <property type="gene ID" value="SAMN04489712_10278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="8">
        <location>
            <begin position="69"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF79781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="637" mass="73176" checksum="E07BA7D3E5DAAD02" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VJS7</accession>
    <name>A0A1H5VJS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87443">
        <property type="protein sequence ID" value="SEF87443"/>
        <property type="gene ID" value="SAMN04489712_102346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF87443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="20951" checksum="349845B6BAE6D61E" modified="2017-01-18" version="1">MRDVLYLDRIEQAEALLKPQRIEVLRQLAEPRTCTEVGERLEQTPQRVYYHVKRLVEAGLVTKVAERRVRGVSEGIYQATARSYWMSPGLVGRLGPRRARDELTLGYLLDLMEEVQADIAALDRTAPELPSIGVSGHIHVPPERRGEFLNDMQTVLQDLFTRYGGEEGDAFKLVVACYPKGEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VY45</accession>
    <name>A0A1H5VY45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91477">
        <property type="protein sequence ID" value="SEF91477"/>
        <property type="gene ID" value="SAMN04489712_102487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF91477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="22948" checksum="428FE77F6CC82F57" modified="2017-01-18" version="1">MNDDSVIKSVIKVLLVDDHPVVREGLRGMLTAEPGLEVVGEAGGAAEAVAAVGLHEPDVVLMDLRMPGGDGVEATARVLARRPATRVVVLTTYETDADILRAVEAGAAGYLLKDATRQDLAQAVRAAARGETVLAPSVAAKLVSRMRAPVDLSPREIEVLALVARGHTNAEIGRELFISEATVKTHLLRAFGKLGVGDRTAAVTVAMERGILAPPDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W047</accession>
    <name>A0A1H5W047_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92491">
        <property type="protein sequence ID" value="SEF92491"/>
        <property type="gene ID" value="SAMN04489712_102526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF92491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="115" mass="12695" checksum="B61EEA9BAEC8FC0B" modified="2017-01-18" version="1">MAIQGRIPVEFGQVFPHGVFATDAAQPLENYDTKRQETDKETGLPVWVVNVYDADPAAKHKASAIRVRVLAKVCPVLPEPVMGPFRPVEFTGPPRGVHRHDRHPVRGAGRQEPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W2F9</accession>
    <name>A0A1H5W2F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, MSMEG_4141 family/probable F420-dependent oxidoreductase, Rv3093c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93724">
        <property type="protein sequence ID" value="SEF93724"/>
        <property type="gene ID" value="SAMN04489712_102566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022526">
        <property type="entry name" value="F420_Rv3093c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03841">
        <property type="entry name" value="F420_Rv3093c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF93724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="33734" checksum="0A73F8465533DE28" modified="2017-01-18" version="1">MTARWGLTIPMTGVPLAEHREIVAGLTDLGYTDAWSAETNGADAFTPLALASQWDPGLRLGTAIVPVYTRGPALLAQQAATLAGLAPGRFVLGVGTSSETIVQRWNGIPFTEPYQRVRDTLRFLRKALAGEKVTDEAVGVKGFKLDGAPDEPPSIVLAALRPGMLRLAAREADGAITNWLSPDDVRTVRGVLGDGPELLARLFVCPTDDAEEARRIGRWMIAAYMTVPVYAAFHEWLGRGDALKPMNDAWAAGDRKGALAAIPDEVVDDLIVHGSPAACRDRIRQYVDAGLTTPIVAVVPGGGLSPAEAVRALAPSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XHB5</accession>
    <name>A0A1H5XHB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10596">
        <property type="protein sequence ID" value="SEG10596"/>
        <property type="gene ID" value="SAMN04489712_103234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="104"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG10596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="37012" checksum="204EA0A678EC82B8" modified="2017-01-18" version="1">MATTVKNRPDAVPRPAAGARRGRRPKGDAQSSRRLAAVLLSPTLLVLALVVGYPVIAGFRESLYSRGQQLDADGFVVEGERFVGLDNYTAVFSGDRGDAFWNAFYNTTFFTVTTVALETVIGVVMALIMHQAFRGRAFVRASILVPWAIPTAISGLLWRWIFQHDGVANAVLRQQVLWTADGLESKIAVIIAEVWKTSPFIGLLVLAGLQMIPREVYEAARVDGAGPLQRFWRITLPLVKPTLLVAVLFRMLDALRMFDLPAVLIGVNKDSVETLTMLSWFEANNVRYGSAAAYATILFVYIAVIAYLFVRLLGADIIGQAKQTGKQRQTRKKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XJW4</accession>
    <name>A0A1H5XJW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12074">
        <property type="protein sequence ID" value="SEG12074"/>
        <property type="gene ID" value="SAMN04489712_103290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG12074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="29339" checksum="125FE4DC22400A24" modified="2017-01-18" version="1">MSGDGDGPPDRAQDDTGDLGVPAPRDGGRNAEIAELVGRLAGDDLDPDSRRRLLGRLTRLLAEGARRTGATGLRGGRWLADLLMEITPHLPVRDAPTLSAHHHGLTGERLADSLVRVAANGTTAVGAAGGALAAVQFTAPPLLLTAPAQIAAETLVISAIEVKLIAELHAVYGVDIPGSGTARAGAFLTSWARRRGINPLETGSLTNALGTAAKTALRKRLLRTFGRSMSTMGPFLTGAAAGATLNRTATKRLAEAVREDLRRHMGPAPAVPHVLPRPPLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XPJ7</accession>
    <name>A0A1H5XPJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13689">
        <property type="protein sequence ID" value="SEG13689"/>
        <property type="gene ID" value="SAMN04489712_103350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG13689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="30350" checksum="66644ABBFE2BBC21" modified="2017-01-18" version="1">MTEGRLRTFVALADTGSVRAAAERLYVTESAVSAAVAALARELGVAVVERRGRGVRLTPAGEAYATYARQVLGLLEQGRAAARGQADPGRGTLRLAAVTTAADQVLPRLLAGFRARWPGVELTLEVGPSRQVWRRLADHEADLVLGGRPPAGVPATVLATRPNDLVVVTAPGVEFDLRTTPWVMREPGSGTRVTAEAYLAERDADPPQLVLGSNGAVIAGAAAGLGAALVSRDAVGAELADGRLVVIDAPGTPLHRPWHAVSGVSPTATTRLFVERLLEAPGWRPAGGRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y1B6</accession>
    <name>A0A1H5Y1B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17733">
        <property type="protein sequence ID" value="SEG17733"/>
        <property type="gene ID" value="SAMN04489712_103507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290067" evidence="2">
        <location>
            <begin position="29"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="124"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG17733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="37710" checksum="C9AFA0CDB9A8AE4E" modified="2017-01-18" version="1">MRRKSIAGPLAKSIAFIVVTVVATAALAISIANTGVGDTVAYKARFTDTTGLIIGDSVRIAGVRVGQVEGIRVVDRRLAEVTFNVERDRRLPATTTATIKYLNMVGQRFVELGRGEGQATGQAATLRPGDTIPEQRTTPALDLTQLFDGFQPLFQALSPNDINKLAGELISVFQGEGATVQSLVSTVGSLTSTLAAKDKVIGQVIDNLTTVVETVNAREGQFVTLVSTLRQLVQGFAADRRVFGEAIVSLSDLADTTSSLLRDSRDPLREDIKQLGRLSENLADSTPALETFLRRLPVKMQTIGRVASYGSWLNFYLCEATVRGVSWEHTGGEDHGPPPTGIPVTEQRCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YL57</accession>
    <name>A0A1H5YL57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron(III) transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24460">
        <property type="protein sequence ID" value="SEG24460"/>
        <property type="gene ID" value="SAMN04489712_10459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG24460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="36126" checksum="F93E356CB317F4A7" modified="2017-01-18" version="1">MTELQIEGLTKAYGPDTTVLHGLDLTVPSGSLAAVLGPSGCGKTTLLRIIAGFLRADAGTVTVGGRTLTGPGTHIPPERRRIGIVPQEGALFPHLSVARNVAFGLTDRAARRRRTEEMLDLVGLAGYGDRMPHELSGGQQQRVALARALAPEPALVLLDEPFNALDSALRAGVRADVRAALRATGATALLVTHDQQEALSTADLVAVVREGRVAQCGSPQDVYSRPIDPWVAGFVGDAVPLPGTAVNDTATTALGTVELRTPTEAPLQGTVLLRPEQLRLTEPGETTPDGIVTDVRYYGHDAMITITVDGLDTPVDIRIGGHVPLRPGDRTGIRITGQATFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YNE1</accession>
    <name>A0A1H5YNE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25514">
        <property type="protein sequence ID" value="SEG25514"/>
        <property type="gene ID" value="SAMN04489712_10497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="53"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG25514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="322" mass="34413" checksum="FAACE456AE935CC6" modified="2017-01-18" version="1">MSEPVIDVCEVAYDTECWTAYLGALATVAPRYLVLFAGRLATLTGRAPGDVAAEAARDPAGTADRLAAVLGRGFDIDHHVAALAETGVRHQVLHGGPWTIGDGTVNDRVAAYAARHPDRLSAWAGVGLTDPRAAITEARRALDELGATGLSVIPFLDGVDPSGPEYEGFWRFAADRGVPVWLHCGQHFRSDVAIDVSAPRVLDRIAGAHPDLVLVAGHGGWPWVTEMLAVVQRHTNVYLEFSSHRPARMGDRGSGWEALLALGTASVRTRVLFGSTSWTQARPPAALAAEVTRLGLPDDVVRAWLHDNAERLLNRVRPGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z273</accession>
    <name>A0A1H5Z273_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29725">
        <property type="protein sequence ID" value="SEG29725"/>
        <property type="gene ID" value="SAMN04489712_104279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG29725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="9226" checksum="E2D5FB4C66D4CAB0" modified="2017-01-18" version="1">MYVIRLPDGTLRVPTSATTDDGRIIGQGYVEVGPGDPDYDRLLRQSLTEEELEEKRRGWREGDEALLREFEEWKATQAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZC26</accession>
    <name>A0A1H5ZC26_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_104481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34049">
        <property type="protein sequence ID" value="SEG34049"/>
        <property type="gene ID" value="SAMN04489712_104481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="8">
        <location>
            <begin position="32"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="9">
        <location>
            <begin position="412"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="577" mass="63247" checksum="406BC5D1D7A4F56B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZFF9</accession>
    <name>A0A1H5ZFF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34136">
        <property type="protein sequence ID" value="SEG34136"/>
        <property type="gene ID" value="SAMN04489712_104485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="27"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG34136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="521" mass="57156" checksum="C7F1A501D9E0112D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZGH8</accession>
    <name>A0A1H5ZGH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35372">
        <property type="protein sequence ID" value="SEG35372"/>
        <property type="gene ID" value="SAMN04489712_104543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="223"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="440" mass="46604" checksum="3617F9EEBE521305" modified="2017-01-18" version="1">MTQPGPGVMPGLEPAAVADEPRSEPDVSPWDGAALQMQLDAFLARTGRRLIDFRRDLHMHPELGYAEHRTTEQIVRALTEVGLRPRVLPKGTGVICDVGTADGPTVALRADIDALPLMDEKDVPYRSTVPGVAHACGHDVHTTMVLGTGLFLAQQAAAGLLPGRVRLLFQPAEENPGGALDVMAAGGIAGVDRVFALHCDPRIEVGEVGLRAGPITAACDKVYVRVTGPGGHTARPHLTADLVYALAKIVTELPAALSRRVDPRSSLSLVWGRVAAGSVANAIPDDGIAEGTVRCLDDEAWHKAPEMMKALLQSVAAAYDVEASLEYVRGVPPTVNEPTSVQMFRDAAIQMLGETAPVPTPQSLGGEDFGWYLESVPGALARLGVRTPGSAEEYDLHRGDFDVDESCIGVGVRFLSATALTALWDGRRSMTDELGDTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A3W7</accession>
    <name>A0A1H6A3W7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_105175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43052">
        <property type="protein sequence ID" value="SEG43052"/>
        <property type="gene ID" value="SAMN04489712_105175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="329"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG43052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="575" mass="63480" checksum="AECC78B889535455" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A5I6</accession>
    <name>A0A1H6A5I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43691">
        <property type="protein sequence ID" value="SEG43691"/>
        <property type="gene ID" value="SAMN04489712_105212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025557">
        <property type="entry name" value="DUF4282"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14110">
        <property type="entry name" value="DUF4282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG43691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="11120" checksum="B65F4CB5320B779C" modified="2017-01-18" version="1">MIGALLDTRFDHLVTPKLIRLWYVVALLLISMQCLVFLALGLWILTWEDGWAWGLMTVIATPLVWLFEALMVRIVMEAVVVRFKGVEHLRVIKDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABQ0</accession>
    <name>A0A1H6ABQ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="11" type="ORF">SAMN04489712_105329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45881">
        <property type="protein sequence ID" value="SEG45881"/>
        <property type="gene ID" value="SAMN04489712_105329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="86"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG45881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="17896" checksum="363988E08FA59A77" modified="2017-01-18" version="1">MTETRADNVNWLTQEAYDRLKAELEHLSGPGRIEIAQKIEAAREEGDLRENGGYHAAKEEQGKIEGRILQIQHILENSQVGEAPRTDGVVGPGMTVTVAFEGDDEEVTFLLASREESGAPIDVYSPKSPLGAAINGKKVGEKATYTLPNGRSMTVEIIDATAYAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AC67</accession>
    <name>A0A1H6AC67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46071">
        <property type="protein sequence ID" value="SEG46071"/>
        <property type="gene ID" value="SAMN04489712_105341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG46071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="178" mass="19331" checksum="EF565241786AE62A" modified="2017-01-18" version="1">MSTSDRLLLILHVGFAIFTLGPLTAATMATPRYIRHRNVGVLRYLHRATRLYGLLTLGIFLFGLFLAKGQFAQVWLSASMTLFIVAIGLLLLVERDQRRAIHLLEVAAAEGVQAPAPAAGKVRGPEEQTATATEPETAPAPAPAPEIAQVERGRIAAISGVIALLWLVILILMIWYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AD11</accession>
    <name>A0A1H6AD11_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_105333</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45937">
        <property type="protein sequence ID" value="SEG45937"/>
        <property type="gene ID" value="SAMN04489712_105333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="60"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="343"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG45937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="493" mass="52892" checksum="327999E0FE1E006C" modified="2017-01-18" version="1">MALTLAASLTACQVSFRSDGSQPSESVPAPTAAGPNVPGGLDSAGDDYVPGDGNGGYDVQHYKLDLDIRPGQSPELSATADITAKATQRLSRFNLDLTGLNVAEVKVNGGAARHERQGSELVVSPPQALAKDADFTVTVRYSGTPRPVSKPPLGIYGWVRTSDGVFVACQPSGAHTWFPSNDHPSDKATFEFRVTVPQGLTAIANGEPDGALPSGSPSPGPSTGQTGGAGVVPVAHRAAAPVTWRVKEPMAPYLATVTVGRFDVRTGKSPGGIPVITAVDPAVVNTDVAEFHAKNAEITDAFVKMFGPYPFSSTGGLVDNADVGFALETQTRPVYGSFGADEGIVAHELAHMWFGDSVSVTRWKDIWLNEGFATYAEWIWSERVTGKSPQQQFDELYRQADNPSLWKVATGDPGRDEMFSSDAVYNRGAMTLHALRKKVGDDTFFKILKTWTDRYRHANATTPQFIEVAEQVSGQQLDSFFQAWLYQRSRPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AGL9</accession>
    <name>A0A1H6AGL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47913">
        <property type="protein sequence ID" value="SEG47913"/>
        <property type="gene ID" value="SAMN04489712_105447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="28"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG47913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="376" mass="39969" checksum="E84E51E08661F67D" modified="2017-01-18" version="1">MTEMIAGFGMPSPSQLVAGATCHTPERVVGNTPVLWIPELIEGGGGFWAKLEGGNPGGIKDRAALHIVERARRRGDLAPGAPIVESTSGTFGLGLALAGIVHGHPVTLVTDPGMEPLMRHLLGAYGARIEMVDRPHPRGGWQQARRERVESLMAPGAYWPDQYNNPDNVTAYQGLAAELAGQLGRIDVLVCSVGTGGHSAGVSRALRGYYPDLRLVGVDTIGSTIFGQPARPRLMRGLGSSVHPRNVDYGAFSEVHWVAPGEAVWTCRRLAALRYATGGWSVGAVALVASWLARTLPGHTRIAAVFPDGPHRYFDTVYNDDYCAANRLLEAPPAADPDQIAHPSEREPVRWTRCTTVIDPLGSSRPASGGNGSGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AGN6</accession>
    <name>A0A1H6AGN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SAMN04489712_105427</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47552">
        <property type="protein sequence ID" value="SEG47552"/>
        <property type="gene ID" value="SAMN04489712_105427"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="13">
        <location>
            <begin position="40"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="14">
        <location>
            <begin position="330"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEG47552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="530" mass="58352" checksum="9DE2207752318AD2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AIE0</accession>
    <name>A0A1H6AIE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CRISPR-associated helicase, Cas3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_105480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48519">
        <property type="protein sequence ID" value="SEG48519"/>
        <property type="gene ID" value="SAMN04489712_105480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF5">
        <property type="entry name" value="PTHR47959:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG48519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="787" mass="86091" checksum="E07C2F1112FE68B9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AVC2</accession>
    <name>A0A1H6AVC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress response protein SCP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52332">
        <property type="protein sequence ID" value="SEG52332"/>
        <property type="gene ID" value="SAMN04489712_10623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019303">
        <property type="entry name" value="vWA_TerF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10138">
        <property type="entry name" value="vWA-TerF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="295"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG52332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="514" mass="54534" checksum="6FFFE7D58C5D571E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AVT1</accession>
    <name>A0A1H6AVT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-oxo-dGTP diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52394">
        <property type="protein sequence ID" value="SEG52394"/>
        <property type="gene ID" value="SAMN04489712_10628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG52394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="27874" checksum="80907C2483765259" modified="2017-01-18" version="1">MINRSDSRAREQVLVTVDLVIFTVREDRLQVLLIERGQPPFEGRLALPGGYIRVGERLDAAALRELQEETGVDGSQLHLEQLRTYGDPERDPRGRVITVAYLALTPDMPVARAGTDARSADWRPVDQVLQEEAGLAFDHDVILREALERARSQLEYTTVASAFCIEPFTIADLRCVYEVVWGFKLDPSNFRRKVTRTDGFVEPTGEHRVQELGRPAALYRRGTARLLSPPLLRSSEVAHSQLSTAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXZ4</accession>
    <name>A0A1H6AXZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52955">
        <property type="protein sequence ID" value="SEG52955"/>
        <property type="gene ID" value="SAMN04489712_10664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="216" mass="24530" checksum="B0BA1B087A2749DB" modified="2017-01-18" version="1">MPHRHAIDLINDEILIYFPYNRENNRALREYTQPINLHWDRSRRAYCLDAAEADSPEVCDILRGFASRRGLRFNRAAAARLGAFVTRSTGERIRAEIRAIDHLLTVQTMPNPAADGQDELHDRLHARRRALTAILTWPAFPRRPEGCDIASPGCLFHLRYDDGEEETRVLAVTEIEGYDNIPPHRPLGKTLGTARIGDRIPLGRGRASFTVLDITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYD1</accession>
    <name>A0A1H6AYD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_106102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53581">
        <property type="protein sequence ID" value="SEG53581"/>
        <property type="gene ID" value="SAMN04489712_106102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG53581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="35835" checksum="BC416E04CC286353" modified="2017-01-18" version="1">MTALLDQTPAARTAAAGGRPPRGRGRRIALPYLLLLPAVLLELLVHLVPMLVGLVMSFRKLTQFYIRNWSAAPHAGLDNYRVVLDFDSAVGRSLLHSFWVTIAFTAASVGTAWLFGTAAAVLMQRHFRGRGLLRAFFLVPYALPMYAAVITWAFMLQRDTGMVNALLGRDGPDAPFWLIGGNSFWSLVVVSVWRTWPFAFLIIMAGLQNVPRDLYEAAALDGAGWWRQFREVTQPLLRPVNQVLLLVLFLWTFNDFNTPYVLFGESAPREASLISIHIYQSSFVTWNFGLGSAMSVLLLLFLLLVTAGYLAVTSRRRHAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZV0</accession>
    <name>A0A1H6AZV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-polyprenyl-6-methoxyphenol hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53914">
        <property type="protein sequence ID" value="SEG53914"/>
        <property type="gene ID" value="SAMN04489712_106125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="3">
        <location>
            <begin position="15"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG53914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="485" mass="52975" checksum="90A8987394D86894" modified="2017-01-18" version="1">MTGIGHGDRTGKHAVVIGGGIGGLLAARVLSESFARVSVIERDEPNSGATPRRGVPQGHHTHGLLARGREIVEELFPGLTAELTDLGAVPCDIQDDCVWYNDGRRLYPAPSRLRGLAVSRPRLEDFLRARVADLPNVEIRSRCEVVGLLPAAGGVRVRPAGGAEAEDVPADLVVNACGRGRRGAAWLAELGYRTPAEERVDSRLVYVTREYRAHPGDADATSILVAHGAAAPRGGFAIRVEGDRWLITLLGMGDDVPPTDPDEYERFAATLPIPDIHLLMRRLQPLGPPRLMRIPTSVRHRYERLRRLPKRYVVLGDALCRFNPSYGQGMTVAACQAIALREALREGPDDVARRFFRLAARIIDVPWDMGVCGDLRFPHVQGRRTPRVRLLNAYLAQVHVAAEDDPVVGEAFLSVVNMVAPPQSLFAPRLLRRVLRRRPEGARLVRHPAPVFAEDVLPSVPQLTGQETDMETHATTRAAAAPQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2B7</accession>
    <name>A0A1H6B2B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_106176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54742">
        <property type="protein sequence ID" value="SEG54742"/>
        <property type="gene ID" value="SAMN04489712_106176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="88"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG54742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="29432" checksum="FC0DDD6B37DCDAAF" modified="2017-01-18" version="1">MSRSATNPSKAAATEEGEGQSRSIAAVERAMDVLLLFGRSTRPDLGVTEIATELGLTKAAVHRILTALRSRELITVDPVTRRYALGHAAIALGRAYLARMDLRAMAAPELRRLAQQTGETATLSIRRGDTRLYVDQVVPPNELRMEVSLGIPYPLHAGSSSKVILAFLDDIEVDGYLRRHPLEALTDKTLVDEGRLRKELAAIRRRGYATSLGERQEGAASVAAPIFDHDGRVIAGLSVAGPLTRFKPRLNECAPLVVESAVRISAQLGHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B4M0</accession>
    <name>A0A1H6B4M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55157">
        <property type="protein sequence ID" value="SEG55157"/>
        <property type="gene ID" value="SAMN04489712_106208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG55157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24302" checksum="A9DC483456EFA710" modified="2017-01-18" version="1">MRPFLPNRRALTVQEPSCKRKSYLAAVTSTTRERILDAALALIMRHGFGGTAVTDIEAAAGLSPGSGSFYRHFRSKEEVFTAVFERELERAQEHRRTFERGPVTGDPQEVLARRFRQQLAYLTAVRPLIALLAREHTRFPELADKIGGVLLDEGISEEAAHLSGDLGTRLLSDDPHATLAVVVSALTGYHLAREFFGHPPADIDEHRFAAALAALLAPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6Q4</accession>
    <name>A0A1H6B6Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56488">
        <property type="protein sequence ID" value="SEG56488"/>
        <property type="gene ID" value="SAMN04489712_106316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG56488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="13221" checksum="B8B3846AECF93812" modified="2017-01-18" version="1">MANIDIALKDIMAIDGAVGAAVVDYGSGMALGTLSSSKVLDLNVAAAGNTEVVRAKLRTMEQLGLKDDIEDILITLSGQYHIIRPLTGRKNSGLFLYAALDRSRANLALARHRLKSIEEELEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B7B4</accession>
    <name>A0A1H6B7B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor type A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56753">
        <property type="protein sequence ID" value="SEG56753"/>
        <property type="gene ID" value="SAMN04489712_106334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="650"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG56753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="851" mass="87502" checksum="A76EF41F2B2BF2D0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B7J3</accession>
    <name>A0A1H6B7J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56823">
        <property type="protein sequence ID" value="SEG56823"/>
        <property type="gene ID" value="SAMN04489712_106339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23937" checksum="8A40A40C36BA55A7" modified="2017-01-18" version="1">MSTTELSSTSRTRLGRARERGLTDRTSLYEVLDAGMICHLGVVVDGLPRVIPTGYGRDGDILYLHGSTGARSLTEGSRQEVCVTVTHLDGIVLARSIFHHSVNYRSAMIYGTPRRVTDPDELLTALRAISERLAPGRWDAARPPTRRELAATAVLALPLEEASVKMRQGPPSDDEEDHSLGVWAGVLPVHQVFGEPVPDPRLRPGIPVPDHVRGRSAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BIU4</accession>
    <name>A0A1H6BIU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60659">
        <property type="protein sequence ID" value="SEG60659"/>
        <property type="gene ID" value="SAMN04489712_107147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="22833" checksum="1DFF5B123616E572" modified="2017-01-18" version="1">MTTHPHDEHGEILRRALHAEADRVEPAPDGLERIRAGIERRSRRRFAGLAGWAPVRFWPPGGWSRPVLAVGAAVAIVAVGVSAPQTIDRITSAGRHGPADGDERPSGAVSGTGSAGQVGQLPPAAGPGQQTAPLPGQPPTSPVPGAPGAPPCTPVEQPSPGQPSATAGPEGPQLTATPCPEPSGPSASPEPSDEPSSPEPTEPQEPPTDPNTPSPTPEPQQTESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BK59</accession>
    <name>A0A1H6BK59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_107180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61063">
        <property type="protein sequence ID" value="SEG61063"/>
        <property type="gene ID" value="SAMN04489712_107180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="97"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG61063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="35109" checksum="E399261E0397E790" modified="2017-01-18" version="1">MAGFLVRRLLNYGVLVVLAASLAYLLAAATLRPRAEFAERSPRPPAAVVDAQLTALNLNDKTPLARRYATWASGVLHGDLGRTLNGDPVAPELLRRALVSVRLLLVGTVLGGVLGVLAGAYAAVRQYRPSDRLITVGSFVVLSTPVFVLAVLLQLGAERVNQATGVRIFEWVGEYTPGHGAGPLARLGGRLQHLVLPTLAIVLTQVAVVSRYQRHLMLDVLGADYVRTAMARGLTRRRALLRHGLRTALAPVTTYFAYTFGFVLLGAMFTEKIFGWHGMGGWLIDSVHRGDVNAVAAVNLLAAVLVLLAGLAADAAHGLLDPRVRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLZ4</accession>
    <name>A0A1H6BLZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase RecJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61738">
        <property type="protein sequence ID" value="SEG61738"/>
        <property type="gene ID" value="SAMN04489712_107240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="260"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG61738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="354" mass="37268" checksum="8D04CCFD3699449C" modified="2017-01-18" version="1">MPVPTAAGHARDGASEQDRWERAVRLIEAAGEVWLACHVSPDGDALGSMLAFGQALRTLGRRCAASFGEPFTVPASLGFLPGQELLAEPGRVPAAPELMITFDAASLERLGSLAGPAGRARELIVIDHHASNTGFGTVRLVDPAAAATAVLTERLIERLGVPLTRDIACGLYAGLASDTGSFKYGSTTPEVHGMAGRLLAAGVRPDTVGRELWDRAPFGYLQVLGGALGRARFEPEAVGGLGLVWTTISRADRAARDVRYDQLEGVIDQLRRADEAEVAVVCKETDDGRWYVSTRSKGRVDVGRVCVELGGGGHRLAAAYTCDCTPAAAIDRLRELLTSPVGDCAGTPAARETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BMM0</accession>
    <name>A0A1H6BMM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">SAMN04489712_107232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61657">
        <property type="protein sequence ID" value="SEG61657"/>
        <property type="gene ID" value="SAMN04489712_107232"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="107"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="101"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG61657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="25809" checksum="A734FE2864FEF7A5" modified="2017-01-18" version="1">MIKVGVLGARGRMGAEVCRAVEGADDLELVAAVDQGDAREALTAAEVVVDFTHPGVVMDNLRWCVEQGLHTVVGTSGFGPERVAEVRSWQEAHPGGNVLIGPNFGIGAVLMMDFARRAAPFFESVEIVELHHPNKADAPSGTAHRTAELIAEARAAAGAGPSPDATTSELDGARGADVEGVRVHAVRLAGLIAHQEVLLGGHGEVFTLRHDSMNRESFMPGVLLAVRRVAGLPDRLTVGIESLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BN02</accession>
    <name>A0A1H6BN02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protocatechuate 3,4-dioxygenase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_107269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62050">
        <property type="protein sequence ID" value="SEG62050"/>
        <property type="gene ID" value="SAMN04489712_107269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024756">
        <property type="entry name" value="PCDO_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012785">
        <property type="entry name" value="Protocat_dOase_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12391">
        <property type="entry name" value="PCDO_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02422">
        <property type="entry name" value="protocat_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="4">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG62050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="28708" checksum="FB209DC32CAB71C5" modified="2017-01-18" version="1">MAETQETISAEIAELRDAYAKAVADGGPRSDHPARDYRPYRSSVLRHPKRPLVTVRDPEAVELSGPVFGVTDVTDLDSDLTRQHSGEPQGERITVTGRVLDRAGRPVRGQLVEIWQANAAGRYAHQRDQHPAPLDPNFTGVGRCLTDDEGRYAFTTIKPGPYPWRNHDNAWRPAHIHFSLFGTAFTQRLITQMYFPGDPLFRYDPIMQSVTDDAARQRMVAEYVHDLSVPEWSMGYRWDIVLDGPAATWIEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNE5</accession>
    <name>A0A1H6BNE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/amide ABC transporter membrane protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_107262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61975">
        <property type="protein sequence ID" value="SEG61975"/>
        <property type="gene ID" value="SAMN04489712_107262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG61975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="35096" checksum="2AEC28E8530D511D" modified="2017-01-18" version="1">MKPSPRVLVAAAVCAAALAAPLLLSEAQVSVYVLLLLAACVVTGLSMLMGYAGQVSLGQASFFMVGGYTAALITTHGRPSWLGLAAAPLVAAALAALIGVPLLRLRGHQLAFATLAVQLILLNLVGQQEWTGGDIGLQGVPRLEIAGYEFATDLSYAYLALAALGLIALITRNIVASRPGRGLRALATSEVAAASSGVPVATYKLAVFSLSAGFAGLAGGIYAFYIGYVAPGSFPVLLSFEYVVMVVVGGAGTVYGALAGATVITLLLQLLNNVGTMEGMPAAAPTVLSYAVYGLLLILIVLFMPRGLVPSATGWWERRAARGAPASDEPDAAPVRDLARTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPP7</accession>
    <name>A0A1H6BPP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_107314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62689">
        <property type="protein sequence ID" value="SEG62689"/>
        <property type="gene ID" value="SAMN04489712_107314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG62689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="21227" checksum="60958DA9DAE6AF65" modified="2017-01-18" version="1">MDAAAERQFREFVTARSPALMRLAFLLAGGDAHAAEDLLQTSLAKTAARWRTVEDLESYVRTVMYRQQVSWWRRGVRRRETTIAEPPDVAARADDTHALELRLVMRGALAKLTAKQRTVLVLRYFEDLPDTEVARLLGCSVGTVRSTAHRSLARLRTLAPELAELRGLEPEQAAGRSASAESMTLKEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BWX8</accession>
    <name>A0A1H6BWX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane proteinase PrsW, cleaves anti-sigma factor RsiW, M82 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65163">
        <property type="protein sequence ID" value="SEG65163"/>
        <property type="gene ID" value="SAMN04489712_10882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="42001" checksum="8EBCF459FF49437C" modified="2017-01-18" version="1">MVRMDPQAVLEGRVPGRPPVGLILGLIVSTLCALVVLGALAWFGGAGFVAALLLAVLPIPPLIALVLALDRLEPEPPRTVALAFMWGAGVAVLGALVLNTAGMIYVTVPIFGETEGHFVSATVGAPLVEETLKGAVLFGLLWFRRNEIDGFADGLIYAAMVGLGFAMMENITYYMRALEEGGTGQLTAVFVLRGVIAPLSHPLFTSMLGLGVAWSATHRRGRVVAPVLGLLAAMVLHGLWNGSAALGAAGLVVVYGLDFCLLLVLIVIVLLERRGIVQRIERYLPMYEGTGLVTPQDVRMLGRLSSRRAARRWARATGGPMAARAMSDYQLAATELALLHKRAERGVADPAWLAQRRDALLGLMAVARQAFLWAPQHGVTGPPWAPGGPSGPPPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BWY5</accession>
    <name>A0A1H6BWY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64965">
        <property type="protein sequence ID" value="SEG64965"/>
        <property type="gene ID" value="SAMN04489712_10867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="73"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG64965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="23129" checksum="740447286B22E17E" modified="2017-01-18" version="1">MSHPRADETDDGRLPPLDPRALSEAQREVYEAVTAGPRAARPPAFRITDGDGRLLGPFNAMLYSPAVGLPLQDLGSALRFRTGFTAREREIATLTAAAHWRSDYEWYAHERIGRRAGLTQAELDALREGRDPVLADARERVVHAATRELLAHGDLGDALYAEAAATLGRAALVELVTLVGYYGVLALQMRVFRVGVPEGETAPFRRDDPGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZ59</accession>
    <name>A0A1H6BZ59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetaldehyde dehydrogenase [acetylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_108156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:23288"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the acetaldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65999">
        <property type="protein sequence ID" value="SEG65999"/>
        <property type="gene ID" value="SAMN04489712_108156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01657">
        <property type="entry name" value="Ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003361">
        <property type="entry name" value="Acetaldehyde_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015426">
        <property type="entry name" value="Acetylaldehyde_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09290">
        <property type="entry name" value="AcetDehyd-dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015689">
        <property type="entry name" value="Actaldh_dh_actl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03215">
        <property type="entry name" value="ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="160"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG65999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="309" mass="32277" checksum="CED416EEB4B230A5" modified="2017-01-18" version="1">MKKTKVAVIGSGNIGTDLMIKVLRLSETLEMAAMVGIDPDSDGLARARRLKVPTTHEGVDGLIGMDGFADIDLVFDATSAKAHLANAARLAPYGKTLIDLTPAAIGPYVVPPVNLGQHLDAGNVNMVTCGGQATIPIVHAISRVAPVAYAEIVASISSRSAGPGTRANIDEFTETTARAIERVGGAGRGKAIIILNPAEPPLIMRDTVFCLIGDADEGQIRASVEKMVAEVSQYVPGYRLKQQVQFTPIPADEPVHTLLPGGAGPVTTKVSVFLEVEGAAHYLPAYAGNLDIMTSAALRVAERIALQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8H0</accession>
    <name>A0A1H6C8H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69208">
        <property type="protein sequence ID" value="SEG69208"/>
        <property type="gene ID" value="SAMN04489712_10961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="92"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG69208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="424" mass="46570" checksum="DD8FC1F9149A63CB" modified="2017-01-18" version="1">MQWAASPVRAAAVRKSGLLRSAGIGRVRGVRVDMQGEVAPFRHRAAYFAFDRFPSSKGSAVHIGHMADELFDHYGGGLLGVLGGGGLPRYQREGEREIVRFEEQIPNLIDRAEAYSAWVAWHLRGHLDTLELCHVRDPWSALPVVTAEGRRHRVVYEVNGLPSIEMAHTWPSAAPSTLAKVRDLERLCLERSDAVVVPSRVIGDAVLKLGVPHERIHLVPNGADVPAPAERPGDAPERYIVYVGALQPWQGVDVLLRAFARLADLPELRLVICSSVPERRARPLRRLAERLGVDQRVEWRFTLPHAEVAAWLANAEVSVAPLTACARNLDQGCAPLKVLESMAAGTPVVASDLPAVRELMADGEHGRLVAPDRPAELARAVRVLLEYPDAARAMGGRARRRITDGLTWGHSRSLLAEVYRTISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CBJ2</accession>
    <name>A0A1H6CBJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70304">
        <property type="protein sequence ID" value="SEG70304"/>
        <property type="gene ID" value="SAMN04489712_109159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG70304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="500" mass="51365" checksum="38BD64ECE8FA4A9E" modified="2017-01-18" version="1">MGADHSHHHRAVPAPPGAVRAVLAVIIPLALLALAALIWMWPDGTGPKNAAPSGDPVQMTRVTGTVIGIEHQKCSETGAFPGDWLAPSDPPPGSAAKCGQATVRLTSGAENGKTVVVGLPTGPGALEYATGDKVVLLHMADTGDGNPPYQLNDHDRSNAMWLVGAAFVLAVVAFGRWRGLTALLGLAITFVLLLKFLIPAILEGRSPLLAAIVCAAAIMLTVLYLTHGFTMATSIAVIGTLASLTLTGVLASTAMGMTHLSGVTDESSLNLSLGYDLNLQGLLLAGIIIGSLGVLDDVTVTQAATVSELAHANPAYRFGQLYRAAARVGRAHIASVINTIILAYAGASLPLMLLLSVGKQPLAEVVTGPILAQEIVRSVAGTLGLIAAVPITTALAALTCAARTRPAPDDGHGPAHPDHDHGPDHPHGGHSLPHPRSGHVSAHPDDDHALAPPGGGHTSARPDDDHGRPPPPTGRRRPRPPAAEPDVPPPGWSRSSDPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CD79</accession>
    <name>A0A1H6CD79_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="7" type="ORF">SAMN04489712_109213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70858">
        <property type="protein sequence ID" value="SEG70858"/>
        <property type="gene ID" value="SAMN04489712_109213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009987980" description="Probable endolytic peptidoglycan transglycosylase RlpA" evidence="3">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DPBB_1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG70858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="197" mass="20739" checksum="85B1661FD2BDBB35" modified="2017-01-18" version="1" precursor="true">MRACLRTLLTVSGVAVAAVPAGAWALNNTEETGRAAAAPPATPATSRPLAKDPTKDPAKDPAPRRPAATAEPSKTREAEPRESREPAAAQDSKPRKPKYRVVDTGACQASYYWEPQPTASGERFDPDALTAAHKTLPMHSKVKVTNKNNGKSVVVRINDRGPYVGGRCLDLSKAAMASVGGTGSGVIPVRYQVLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEQ2</accession>
    <name>A0A1H6CEQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein CpaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71510">
        <property type="protein sequence ID" value="SEG71510"/>
        <property type="gene ID" value="SAMN04489712_109278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022399">
        <property type="entry name" value="HlxAse/secretion_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03819">
        <property type="entry name" value="heli_sec_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="58"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG71510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="40198" checksum="8EB267C8822F8D9D" modified="2017-01-18" version="1">MNGHRFVDAVRDRLAGVGGEPTGGQVAAALRAEDRLLGDQEVLTLVDELQADLVGAGPLEPLLRLPEVTDVLVNGPHEVWMDAGAGLVRTSVRFPDEVALRRLAQRLAAKAGRRLDDAAPYVDARLPGGVRLHAVLAPVAPAGTCLSLRLPRRRAFTLDGLVAAEAVPPAGAALLSALVAARPAFLITGGTGTGKTTLLSGLLSLADPRERLVLVEDSAELRPEHPHVVRLEARPPNVEGAGGVTLHDLVRQALRMRPDRLVVGEVRGSEVADLLSALNTGHEGGCGTLHANTATDVPARLEALGCAAGLSREAVHSQVAAALDVVVHLVRDPAGRRRVAEVCTLKRGPDGLVGAIPAVSFTADGQLVAEAGATALADLLGGHWQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CHW4</accession>
    <name>A0A1H6CHW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribose pyrophosphatase YjhB, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72492">
        <property type="protein sequence ID" value="SEG72492"/>
        <property type="gene ID" value="SAMN04489712_1106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG72492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="15676" checksum="364FFADE01F97F75" modified="2017-01-18" version="1">MIRHRTVPELLVFDHVGMPQAGTQVPAGGVQPGEELEQAVLREVFEETGLHTTSLIEQLVVENKPHPDTRQPRRTTYFHLQAPATTADAWNHTVCGDGDDTGLTFACRFLPLPLTQPLADDQDAWLGRINPLWATTTDNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJ69</accession>
    <name>A0A1H6CJ69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72972">
        <property type="protein sequence ID" value="SEG72972"/>
        <property type="gene ID" value="SAMN04489712_11056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294926" evidence="1">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG72972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="17257" checksum="744C6E619DECC600" modified="2017-01-18" version="1">MFHMTYRSVFALGLAAVLLLSACGGSEDDAPSGGGPGGMTVNTDELVEFAECLRGQGIDVPDPKPGQNLANWLSEENRAELRDSRAVAACEDKLPSAVKDRMKDPELQNRLLRFAQCMRDNGVDMPDPKNGRLDFDAIDRDAPNYQEAAGKCRETLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM82</accession>
    <name>A0A1H6CM82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73763">
        <property type="protein sequence ID" value="SEG73763"/>
        <property type="gene ID" value="SAMN04489712_110151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG73763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="23092" checksum="5672B486963EB663" modified="2017-01-18" version="1">MGTDISGFIECRAPALGPGAPRPWRAAINLDLLYDVRSYDAFGCLFGVRNYASFRPLAAGRGLPDDLSATVREVAGRWERHDATWISWAEVAAVDWDEPAEGVDRRLHEYRRQPDGGLEFVGKSLWGPRLTEATGASREEVMAGRVRWGEGQEFVLGDVVFRAEVLRRRDAVPPDGDWKYVWRVMETLAERAGPEDVRLVVWFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSS1</accession>
    <name>A0A1H6CSS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Energy-coupling factor transport system substrate-specific component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76014">
        <property type="protein sequence ID" value="SEG76014"/>
        <property type="gene ID" value="SAMN04489712_111109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017196">
        <property type="entry name" value="ECF_substrate-spec_UCP037395"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037395">
        <property type="entry name" value="UCP037395_ABCper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="29912" checksum="47C56926BEA40C16" modified="2017-01-18" version="1">MTHAVRIRPRTAVALALASAAGLAMFCWPLLITPEPAGIAHTSDAPLIFIVVVPVLIAIVLAEITSGGIDTKALAMLGVLSAINAALRPLGAGVAGIETVFFLLVLAGRVFGPGFGFVLGSTSLFASALLTAGVGPWLPFQMLSSSWVGLGAGLLPRNVRGRREIAMLAVYGVCSAYFFGFIMNLWFWPYTTGVDTQVSYVAGAPVLENLHRFAVFTVVTSTFGWDTGRALTNLAAIVIVGPAVLAALRRASRRAAFDAPVAFDTLCVDERQWPEGKPVRTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4C3</accession>
    <name>A0A1H6D4C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80150">
        <property type="protein sequence ID" value="SEG80150"/>
        <property type="gene ID" value="SAMN04489712_11326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295562" evidence="2">
        <location>
            <begin position="27"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="100"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG80150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="854" mass="90996" checksum="60DA889D9690279A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D670</accession>
    <name>A0A1H6D670_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-6 DNA Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_113149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80772">
        <property type="protein sequence ID" value="SEG80772"/>
        <property type="gene ID" value="SAMN04489712_113149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="4">
        <location>
            <begin position="164"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG80772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="677" mass="73189" checksum="59BE7AC69B27C31E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7R5</accession>
    <name>A0A1H6D7R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, DHA2 family, multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81339">
        <property type="protein sequence ID" value="SEG81339"/>
        <property type="gene ID" value="SAMN04489712_11429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG81339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="497" mass="51062" checksum="CD7081C70307E373" modified="2017-01-18" version="1">MRINRAWLGAALLMLPTLLVAMDTTALLLALPQLSADLGATNVQQLWISDGYGFLVAGMVITMGTLADRIGRRRLLIVGAAAFTVLSVVAAFAVNPLMLIVTRALLGVAGATLAPSTLALLTNMFRDERQRGKAIAIWATCQFTGGALGPVLAGFLLQHFWWGSVFLAAVPAMALLVLAGPVLLPEFRSDQAGRLDPASVGLSLAAVLLVVYGIKQLTVESARAVPALALIVGAAIGILFVRRQLRSETPLLDLRLLRNRPFTAVLVALVCAGIAMAGTGLLVTQYLQNVLGFSPVASAVLFAPMGLGVAVGTMAAPALARRMKETTAIAGGLMGSALGSLLLVGVDGARALPLVMIGIAVLALGTGPLFALGTGLVVGSVPPERAGSAASMSETGNYFGGSLGFALLGVVAAVVYRSRMDGTSDSLAGAVAASRHLPADQGAELLHTAREAFTASLHVTGVIAAVIFAGLAVLILAMRPVTRTAPAALPDYEATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8H6</accession>
    <name>A0A1H6D8H6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 14">Catalase</fullName>
            <ecNumber evidence="3 10 14">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SAMN04489712_11493</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family. HPII subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 14"/>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81601">
        <property type="protein sequence ID" value="SEG81601"/>
        <property type="gene ID" value="SAMN04489712_11493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Catalase"/>
    </dbReference>
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        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 14" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="15">
        <location>
            <begin position="33"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SEG81601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="686" mass="77045" checksum="DBF03E321A9D93CB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8K7</accession>
    <name>A0A1H6D8K7_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Phospholipid/cholesterol/gamma-HCH transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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        </lineage>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
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            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
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            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="SEG81458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="30753" checksum="A3D15B77E818997D" modified="2017-01-18" version="1">MDISVPHAASARLARISSAAAARTADLAEWPVFLCRVLFHSVRDIVLRLRYAKVVALQVSDIVIGVGATVVGGGMIFVIFIMSLFLGTEVGLQAYTGLEVIGAESFMGLIGAFINVRETTPIIAAIALAAQCGSSFTAELGAMRISEEIDALEVMGINSFVYLVCTRVVAALIALVPLYLIALFASFFATRFISTSFFNLAPGVYDYYFYLYLPPRDLFYSAVKVGVFAFAVITVHCYYGYYATGGPAGVGQAAGRAIRLSIVTIVTLNLLLSYLFWGQGGTVRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9G3</accession>
    <name>A0A1H6D9G3_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Phospholipid/cholesterol/gamma-HCH transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11462</name>
    </gene>
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        <lineage>
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            <taxon>Streptosporangiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81463">
        <property type="protein sequence ID" value="SEG81463"/>
        <property type="gene ID" value="SAMN04489712_11462"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="28256" checksum="6875275ABDDB66CD" modified="2017-01-18" version="1">MTFSVSPLGDRLFTRRAYGGLVSLGDLFAIGLEALRRTWDVRTWFWEFVDQCAFLARVTTLPVIMVALPLGATVALQIGDLAGQLGAQSATGGAVIVGLVREVAPMAAALIIAGAGGSAMTSDMGARRIRDELAAMEVMAVNPVHRLVTPRMWAASLVSTMLASLVIVSGAVGGFVFNVLLQGVTPGAYFDGALGLLRVSDLVVTLLKAWLFGMISALVACHAGMNCAQSPIGVGRAVNRSTVVAFMLVFAFNYVITTIYFLAFPPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAB4</accession>
    <name>A0A1H6DAB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4158 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81635">
        <property type="protein sequence ID" value="SEG81635"/>
        <property type="gene ID" value="SAMN04489712_114103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025296">
        <property type="entry name" value="DUF4158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13700">
        <property type="entry name" value="DUF4158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4158" evidence="1">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="92" mass="10158" checksum="004C91D488F71C1C" modified="2017-01-18" version="1">MTVGELEQFFRLDAKARAVVEGKRRPATKLGWAVQWGTVRMLGTFLADTPLKVPAEVVEFAAEQVGVDSACAPDYLARPKTAHEHSWRSVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAM9</accession>
    <name>A0A1H6DAM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/melibiose symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82527">
        <property type="protein sequence ID" value="SEG82527"/>
        <property type="gene ID" value="SAMN04489712_11539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG82527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="419" mass="42500" checksum="867E28DC3356FB51" modified="2017-01-18" version="1">MYFSSNRAADAAVRAGRSGGARRAVAGNVLALGLVSLVTDVSAEMVTAVLPLYLVLTLGLSPLVFGLIDGGYAGVTAVVRLLGGHLADRLQRRKLVAGLGYGVSAAAKLGLLAAGGSPYALGAVLAADRTGKGVRTAPRDALITLSSDPRDLGTAFGVHRAMDTAGALAGPFVAFAVLWAAPGAYDAVFVVSACLGVLGVLLLMLFVRDRPRRAAPASGKPPVSVRAALRLVADRRFGPVCAAAGLLGLFTVSDAFLYLLLQRELDLQAVYLPLLPVGTAVTFLLLSYGCGRLSDRIGARPVFLGGHLLLLAAYVLLLAPLGGPALLVPVLALHGAFYAATDGVLMAAAGPLLPEDLRTSGLAILQTGQALARLLSSVLVGAAWTAWGPGTAVLAAALLLASALPVAGALLRACRAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCC0</accession>
    <name>A0A1H6DCC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="12" type="ORF">SAMN04489712_11592</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82834">
        <property type="protein sequence ID" value="SEG82834"/>
        <property type="gene ID" value="SAMN04489712_11592"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="130"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG82834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="22552" checksum="34C17EF7BA57C038" modified="2017-01-18" version="1">METLAVDHPLVAHKLTVLRDANTDSPTFRRLADELVTLLAYEATRDVRVAETTVRTPLTDAKGVQLATPKPLVVPILRAGLGMLDGMTRLLPTAEVGFLGMIRDEGSLQAQTYATRLPEDLSGRQCYVLDPMLATGGTLAAAVRLLLSRGATDVTAICLLAAPEGLKYMENAFADTDAPIRVVTAAVDSHLNDLGFIVPGLGDAGDRLYGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFC4</accession>
    <name>A0A1H6DFC4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_116137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84068">
        <property type="protein sequence ID" value="SEG84068"/>
        <property type="gene ID" value="SAMN04489712_116137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043763">
        <property type="entry name" value="DUF5709"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18970">
        <property type="entry name" value="DUF5709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5709" evidence="2">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="15075" checksum="DE0F6D7ECD02976B" modified="2017-01-18" version="1">MTQPDHQPQPRNRPEPDPHSRFEDEGIPDLQEGTPEQQRAVDPSEMPLPGDQPVAVDEWGTTAEEQAEGEPMDLKLSREQPDFGERPVDTSQAAGRIVEEDEGVRPDTEKDSVARDVGPDFGGYTAEEQAMRIDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGM3</accession>
    <name>A0A1H6DGM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Indolepyruvate ferredoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_116102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83923">
        <property type="protein sequence ID" value="SEG83923"/>
        <property type="gene ID" value="SAMN04489712_116102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="609"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG83923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1147" mass="122389" checksum="4C21B04B4F38AE1C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHB0</accession>
    <name>A0A1H6DHB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84574">
        <property type="protein sequence ID" value="SEG84574"/>
        <property type="gene ID" value="SAMN04489712_11727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="17326" checksum="9FDDE3B740CD8B75" modified="2017-01-18" version="1">MSRVQLALRVSDLEGSIAFYTRLFGTEPAKVRPGYANFAITEPALKLVLIEGEGDEPTRLDHLGVEVDDTAQVTAATQRLKDAGLATFTENDTSCCYALQDKVWVHGPGAEPWEVYTVKGDADLLNKAEDSPCRCGVPAESADQMPGGGTGEETKTTAGSACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJB0</accession>
    <name>A0A1H6DJB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84903">
        <property type="protein sequence ID" value="SEG84903"/>
        <property type="gene ID" value="SAMN04489712_11789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG84903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="88" mass="9841" checksum="B35153BC1D1B2B38" modified="2017-01-18" version="1">MTKARQVLADLVNRVAYGGEHVVLTRHGRVVAAIVSPEDLELLQRLREGRIDLTQTEPVVSQEAVAHQPQQSAPMRIAAEYRPSGFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMJ2</accession>
    <name>A0A1H6DMJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HMGL-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_119125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86607">
        <property type="protein sequence ID" value="SEG86607"/>
        <property type="gene ID" value="SAMN04489712_119125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="9284" checksum="970D9BFDF0FBEA32" modified="2017-01-18" version="1">MLNRRGLDQALEAGVDEGAAVLDTSTGGFGRCPFALAATGNIATEDLLYMLHRSGIETGLDLEAVAATGIWLGELLDEPAPALLGRAGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DML1</accession>
    <name>A0A1H6DML1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_119106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86540">
        <property type="protein sequence ID" value="SEG86540"/>
        <property type="gene ID" value="SAMN04489712_119106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="118" mass="12923" checksum="D6379F1365D5CCD3" modified="2017-01-18" version="1">MKAIVRNISGADGEYVIQAQSRALELTVHVRSPQEEPVTPARIGELLEAVAETLAAEDRPWTDAEDAALVRSFDAWYDIAAVAAHLGRPMDSVRRRLTRFGRLPAMDPVSGRLLEADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMT1</accession>
    <name>A0A1H6DMT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_119108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86549">
        <property type="protein sequence ID" value="SEG86549"/>
        <property type="gene ID" value="SAMN04489712_119108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008884">
        <property type="entry name" value="TylF_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40036">
        <property type="entry name" value="PTHR40036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="22764" checksum="F6FFD2FF9F5BE1B7" modified="2017-01-18" version="1">MTNAIRAAEFEAREFAGVPVFYDQPSLLEASIRAVDPALLCWVELGFGSGESAMQIRDIAERAGLKMILHGFDSFQGLPEDWGGEAKRGDYTFPRPPLDPPGVRVHQGWFHEAIPQALPDLADQIGFVHVDCDLYSSTRTAFSLLGERLGPGTVIHFDEYWNYLEAEEGELKAFGEFVDGRELGFRYLGYNANYMQASVILLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP45</accession>
    <name>A0A1H6DP45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="5" type="ORF">SAMN04489712_12059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87050">
        <property type="protein sequence ID" value="SEG87050"/>
        <property type="gene ID" value="SAMN04489712_12059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG87050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="17950" checksum="0E75D43DE6C58141" modified="2017-01-18" version="1">MRARSAIWNLENTTPVAVKIKLKRLGKIRNPQYRIVVADSRTKRDGRAIEEIGKYHPKEEPSLIEVNSERAQYWLGVGAQPTEPVLNILKITGDWQKFKGEPGAEGTLKVAEPKADRKALYQAAVQEAMKEDEGAATTPKSKKKAEPKAKADSGEAAEAKSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP66</accession>
    <name>A0A1H6DP66_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87102">
        <property type="protein sequence ID" value="SEG87102"/>
        <property type="gene ID" value="SAMN04489712_12068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG87102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="94" mass="10199" checksum="E6E3C3D38B262D6E" modified="2017-01-18" version="1">MAGNDPIRLTAWARGRVQGVGFRWWVRSRALELGLVGSATNLSDGRVEVVAEGPRDSCERLLELLRGPGAPGRVAGVSERWTDPRGGLDGFVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRH6</accession>
    <name>A0A1H6DRH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxy-6-oxonona-2,4-dienedioate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87830">
        <property type="protein sequence ID" value="SEG87830"/>
        <property type="gene ID" value="SAMN04489712_12112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="30522" checksum="9E5903EC277D6985" modified="2017-01-18" version="1">MSLWTDLLGAEVRYVTAAGTPTRVACLGAGPPVVLLHGRGGHLETFARNLPHLAAAGRRAIAFDLLGHGLTARRPQSRYTVEDLADHALSVLDALGLAEADLVGQSLGGWTAVQLTLRAPERVRRLALIEPAGLQSESERLADATVRAAYEKGGRAYAEPTPEAVRTRLAGLLADPEDVDPELVEVRTALYLPEEAREVHRLVRAADNGRFLLTPQRLAGLDVPVLFLRGEHGHTPATVVEAARAAIPRARLLTIPGAKQWPQYERPALVNTALIDFLSKENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRS3</accession>
    <name>A0A1H6DRS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_120127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87413">
        <property type="protein sequence ID" value="SEG87413"/>
        <property type="gene ID" value="SAMN04489712_120127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="55" mass="5913" checksum="F6626BE2EEF879ED" modified="2017-01-18" version="1">MTERISDVLAPAKPGPVTLRNRVLKSATDEGPGRGDEHMPRICHGTGCMLVEQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVC5</accession>
    <name>A0A1H6DVC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89210">
        <property type="protein sequence ID" value="SEG89210"/>
        <property type="gene ID" value="SAMN04489712_12342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16949" checksum="FA369B286122FA9E" modified="2017-01-18" version="1">MQGERRRLGPRARLWRSAAAAAVLGALCWSSAYGSDDHFPLGPMTQFAFAVDEDGGEIHSHWLEADTADGRRIRLSMDAVGSGLKRAEVEGQMDRLVRDPSLLQGIADGQRRLHPDRPALTKIYVVKQIRTLRRGEVVSTRQFDRVVWTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWG8</accession>
    <name>A0A1H6DWG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpB</name>
        <name evidence="13" type="ORF">SAMN04489712_12429</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89690">
        <property type="protein sequence ID" value="SEG89690"/>
        <property type="gene ID" value="SAMN04489712_12429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="412"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG89690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="863" mass="94639" checksum="A16F6309B5B38706" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZF9</accession>
    <name>A0A1H6DZF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein, ATPase of CpaF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90712">
        <property type="protein sequence ID" value="SEG90712"/>
        <property type="gene ID" value="SAMN04489712_12716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="92"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="433" mass="47070" checksum="02C63DE19FFCEE4C" modified="2017-01-18" version="1">MDHALVKRLRQEVGDRLAQQRRMDAANGLVPMSAEDERQFARALISQVLEEYARAELTSGRRPPGAEEEEALAAGVHAALFGVGRLQPLLEDPEIENIDINGCDRVFIGYADGREVMGEPVADSDEELVELIQILAAYSGLSSRPFDTANPQLDLRLPDGSRLSAVMDVTVRPALSIRRARLGKVFLSDLVGNGTLTPELGRFLRAAVLARKNIMIAGATNAGKTTLLRAVANEIPPAERLITVERALELGLDQFPELHPNVVAFEQRLPNSEGQGEISMAELVRRSLRMNPSRVIVGEVLGDEIVTMLNAMTQGNDGSLSTIHANSSMEVFNRIATYAIQATERLPVEATHMLIAGAIDFVIFIEKRNDYGRGGRLRRYVASVREVTGCDVRVLSSEVFALGPEGYVLPAAPISCGEELAAYGYDPMAGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2I3</accession>
    <name>A0A1H6E2I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91115">
        <property type="protein sequence ID" value="SEG91115"/>
        <property type="gene ID" value="SAMN04489712_12840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG91115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1269" mass="135333" checksum="3E1E067E2D1D61D5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3L1</accession>
    <name>A0A1H6E3L1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_13241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92157">
        <property type="protein sequence ID" value="SEG92157"/>
        <property type="gene ID" value="SAMN04489712_13241"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="198"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG92157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="43262" checksum="6662429DC2876E5F" modified="2017-01-18" version="1">MSGPHPGAGGTGAPPAADRLRTVDEHLAEILGAVPLLAPIDLALLEAEGALLAEPVSAPIPLPPFDNSAMDGYAVVSTDVASASEDSPVTLPVVGDVAAGDTGVSAIRPGLCLRIMTGAPMPAGADAVIPVEWTDGGTVSVRITRPAPPGHYIRRAGEDVQAGQVVLEPGVRLRAPQLGMLAAVGRARVSVRPRPRVVVLSTGDELREPGSEPAFGQIWDSNSFMLTGAVNESEGVGIRAGALTDAPEKVREALEDQLIRADAIITTGGVSMGARDAVKEALTGTLTFTKVAMRPGKPQGFGLLHGIPIFTLPGNPVSAYVSFQVFVRPALLAMQGLPPEPPGAGTAVLTEEVRSPAGLRHYLRGRLSSGEDGDLAVTPAGAQGSHQMGALAAADALIVVPEERDIVPAGERVEIWRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3Y6</accession>
    <name>A0A1H6E3Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91989">
        <property type="protein sequence ID" value="SEG91989"/>
        <property type="gene ID" value="SAMN04489712_13160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="16818" checksum="3C3CC9F48A45A76C" modified="2017-01-18" version="1">MVGPDGKSDLWRLKRPARRASWSRFKEQRRHLKWVDGLGAASEWVEGVAASKIADFAAEADADDADVLSRYEAVKRVALLARLVHTAQARARDDLAQMLCKRMAGNLKNARLKLEEIREQQRAMSERLIGTYRTVLGASPRDVDTLETGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4Z8</accession>
    <name>A0A1H6E4Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-monoxide dehydrogenase medium subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91955">
        <property type="protein sequence ID" value="SEG91955"/>
        <property type="gene ID" value="SAMN04489712_13142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="302" mass="31967" checksum="E2FE10BEA10855B3" modified="2017-01-18" version="1">MFPREGGRVKPAVFSYLDPRTLEEALGALADHGDDASVLAGGQSLVPLLNMRLARPEVVVDVNRVPGLDALRVDAGAVRVGALVRAAAVERDPAVAGALPVLAEAVRHIAHPQIRSRTTIGGNIAHADPSSELPAVLAAVDGAVVLRSAEEERTVGWEEFFVSVFTTAREPEELVTEVVFPVRPELEFRWVEFARHHGDFPVAGVCLGLSLADGAVRQARLAATGVGDRPLRLREVEAALTGSVLGPETAREAGELAGRAVDPPSDVHGSGDFRRAILATLVRRTIESWPGQAQRGRKGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5C2</accession>
    <name>A0A1H6E5C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein, DUF427 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92958">
        <property type="protein sequence ID" value="SEG92958"/>
        <property type="gene ID" value="SAMN04489712_13628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="131" mass="15070" checksum="AC66890FE9636035" modified="2017-01-18" version="1">MEPSGYVDRPDYRVDVRRKRNLIRVTHEGVVLAETTAALVVDEQDHGLVLYIPRADVRTEHLAPSDQTSRCPYKGRAKYWRLRDGDDPIAWEYPQPYTEVAILRDHIAFYQDRTLVQIGTADPVVSTPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5X1</accession>
    <name>A0A1H6E5X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92285">
        <property type="protein sequence ID" value="SEG92285"/>
        <property type="gene ID" value="SAMN04489712_1335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="925"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="994" mass="107377" checksum="6F6AEC79EEA85308" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7E8</accession>
    <name>A0A1H6E7E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_14028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93748">
        <property type="protein sequence ID" value="SEG93748"/>
        <property type="gene ID" value="SAMN04489712_14028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="261"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG93748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="383" mass="40338" checksum="BC48A17EC8D81848" modified="2017-01-18" version="1">MAEAYIIEAARTPVGRRGGALAGIHSADLGAHVISALVDRSGIDPGRVDDVIFGCTDTVGSQAGDIARTAWLVAGMPDHVPGVTVDRQCGSAQQAVHFAAQGVLSGTADLIVAGGVQNMSAIPISTAMAVGEQFGFTTPFAESPGWLARYGDQEVSQFRAAEMIADKWDISREEMEEFALRSHRRAITATDEGRFAKEITPIGGISADEGPRRDTSLEKMAALQPLREGGRLTAALASQISDGAAALLVASERAVADLGLTPRARIHHISVRGDDPVWMLTGPIPATQHALERTGMSIDDFDLIEVNEAFASVVLAWAKETGADLDRVNVNGGGIALGHPIGATGARLMTTMLHELERRGGRYALQTMCEGGGQANVTVIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E995</accession>
    <name>A0A1H6E995_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives, IS30 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94262">
        <property type="protein sequence ID" value="SEG94262"/>
        <property type="gene ID" value="SAMN04489712_1451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="217"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="361" mass="41046" checksum="0271990B48F38D36" modified="2017-01-18" version="1" fragment="single">MPRWAHNKLPSSVKKRYFELLREGHKGAAAAREIGVSTSCGSLWFLDAGGVIVPDLGPISPRFLTQDDRIAIADGLQAGDTVKQIAASIGKSFQTVYREIRRNSKPDGRYQPWWAHNQALLRRQRPKPERIRSSRPLRTVVRHKLADRWSPQQISRFLARTYPGQIDMQACPETIYRALFAGLLGHKPGKLRTGRTRRKPHRRGVPVPNKIKNMTLVAQRPLEANDRHIPGHWEGDLIIGRGQASAIGTLVERTTRYVKLIHLPRGWKAPAFRNALITQTAGIPPELRKTLTWDQGREMALHEDIEALTGFRIYFCDPHAPWQRGTNENTYWCKVGRAGLLRRERLRDGPLGDSENTCRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9U3</accession>
    <name>A0A1H6E9U3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MLTR_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94472">
        <property type="protein sequence ID" value="SEG94472"/>
        <property type="gene ID" value="SAMN04489712_1481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="15277" checksum="47077E760B914F3A" modified="2017-01-18" version="1" fragment="single">ARFTFLDPRSHRFWGDWERAANDTVALLQAEAGRDPYDKDLTDLVGELCTRSEDFRTRWARHDVRQHHLGAKPFHHPVVGDLHLTYESLDLPADDLTLVAYGTEPGSDSEDKLRLLASWAAEVALQPKQSPADQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9X7</accession>
    <name>A0A1H6E9X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93744">
        <property type="protein sequence ID" value="SEG93744"/>
        <property type="gene ID" value="SAMN04489712_14027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28095" checksum="FE19971F31764E27" modified="2017-01-18" version="1">MTTPKTEQPAPAYVPGHRLLEDRTVVVTAAAGAGIGSAAVRRCLEEGARAVVLGDTHERRLAEAGKALGEEFGTDRVAAVLCDVTDESQVAALLEAAEPFGGVDVMINNAGLGGTVSLLDMTDEQWNRVLDITLTGTFRCIRAVGRRMVEAGRKGVIVNNASVIGWRAQEGQAHYAAAKAGVMALTRSAAMDLAPYGIRVNAVSPSLAMHPFLAKVTTAEFLAELKAGEAFGRAAEPWEVANVMVFLASDYSSYLTGEVVSVSSQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAB4</accession>
    <name>A0A1H6EAB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized ACR, YkgG family COG1556</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000049">
        <property type="protein sequence ID" value="SEG94642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94642">
        <property type="protein sequence ID" value="SEG94642"/>
        <property type="gene ID" value="SAMN04489712_14914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="21828" checksum="774B499C76AD8268" modified="2017-01-18" version="1">MTTPTPAIPFTEPAPAQRLERAAAALTAHGFTVEILDDAAAARTRVKDLIPEGAGVFTAASETLRLSGINEDINTSGRYQAVKPRVRAMDRATCADDIRRLVSGPDVVVGSVAALTETGSLVVASASGSQLPAYAGGAARAIWIVGAQKVVPDLSTALRRLEDHVLPLESARAQVIYGQPSAVNSLLILNAEPRPGRGTVLLLREAIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAD1</accession>
    <name>A0A1H6EAD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94079">
        <property type="protein sequence ID" value="SEG94079"/>
        <property type="gene ID" value="SAMN04489712_1435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="21730" checksum="43272E1A4F932F6B" modified="2017-01-18" version="1">MSDLTTTEADHRISVAAGRQARTARAVTELFAPWVLIISLFLAVGWSTGERGVAWGLLGAAFASMGPMTVIVAGVIVGRYTDHHLTTREQRVIPLVLSLIMVVTGIFVLHVLNAPADVLAVEAAMLGGLVVTAPITALWKVSFHTGVASAAVTILAIVYGPVLIALSPIVVLIGWSRVKLAHHTPLQVLLGAPIGTLAATVPFLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAD7</accession>
    <name>A0A1H6EAD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CRISPR-associated endonuclease/helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_14124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93894">
        <property type="protein sequence ID" value="SEG93894"/>
        <property type="gene ID" value="SAMN04489712_14124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041372">
        <property type="entry name" value="Cas3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18395">
        <property type="entry name" value="Cas3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="9">
        <location>
            <begin position="28"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG93894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="967" mass="106247" checksum="A19D56EE07736028" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAS1</accession>
    <name>A0A1H6EAS1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="4">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rtcB</name>
        <name evidence="5" type="ORF">SAMN04489712_1525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3 4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000052">
        <property type="protein sequence ID" value="SEG94822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94822">
        <property type="protein sequence ID" value="SEG94822"/>
        <property type="gene ID" value="SAMN04489712_1525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="323"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="396"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG94822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="473" mass="49895" checksum="E8A9FE2068A2AAED" modified="2017-01-18" version="1">MRIMQETPYRLRIEREGEMRVPGVVFASRALLPDPAADRSLGQVADVATLPGIVTASYAMPDMHWGYGFPIGGVAATDIAAGGVVSPGGVGFDISCGVRLLAAALDRDGLDPRTHQRLMDELGRTIPRGLGRRAVWPLAGRGQLEHVLAEGSRYAVEQGHGTPRDLARCEDHGAVAGADPASVSARAMERGLGQLGSLGSGNHFLEVQAVERVYDEPVAEAFGLRRDRVCVMIHCGSRGLGHQICTDHVHAMQPAMRRHGITVPDRQLACAPVESPEGRAYLAAMAAAANYGRANRQLLTEAARRAFAGTCGADLELVYDVSHNLAKIETHEVDGGSRRLCVHRKGATLAFPPGHPGLPPDLAGSGQPVLIPGTMGTASYVLAGVAGNPAFDSTCHGAGRLQSRHQAVRSVRGRELRDRLEAAGVAVRGASWRGLAEEAPAAYKDIDEVIAVAEGAGLCRKVARLVPLGVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBB8</accession>
    <name>A0A1H6EBB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000044">
        <property type="protein sequence ID" value="SEG94226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94226">
        <property type="protein sequence ID" value="SEG94226"/>
        <property type="gene ID" value="SAMN04489712_14417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="22616" checksum="60D001D4D25FD118" modified="2017-01-18" version="1">MTGPSSYHRRVAEQKREAILGAATRLFLDSGYAGTSLAKVAEAAGVSKATLFKQFPTKAALFDAIVTTSWRIGEEDGAQPPVGDPVAGLTVIGRRYVALLTRPDMADLFRIVIAEMPRFPELAEAQFNRGKMPYFESVRSYLEAERAAGTIVVDDLDLAATQFLGMISNYVFWPQMLLPHWAPDEASMDHVVDEAVLMMRARYGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBS9</accession>
    <name>A0A1H6EBS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_15024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94733">
        <property type="protein sequence ID" value="SEG94733"/>
        <property type="gene ID" value="SAMN04489712_15024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="PTHR31544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GGACT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="15785" checksum="4C47D4C690CD730F" modified="2017-01-18" version="1">MDPEALFVYGSLQFPEVLFTLIDRVPDHDPAAAHGWRVAALPERPYPGLVPGTGTATGYLLTGLTPEEWRVLDAFEDPVYELKRLDLTDGRHGWAYVCNPGATVEPHDWSAEDFQAQHLPAYIDRCAAWRRRHETNQQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ED89</accession>
    <name>A0A1H6ED89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000051">
        <property type="protein sequence ID" value="SEG94775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94775">
        <property type="protein sequence ID" value="SEG94775"/>
        <property type="gene ID" value="SAMN04489712_1514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="13"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="13495" checksum="0BF1C7F9699ED29B" modified="2017-01-18" version="1">MTSETTLRAAPQSEAVELARRLAARTMRTWSLIECEEQVTAIVAELVANAVRHAGTVLELRLQRRPGAVRVEVRDRASAMPQMTVPAPLDESRRGLFIVDRFASDWGAIPVTGGKVVWAEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S0U3</accession>
    <name>A0A1H5S0U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44232">
        <property type="protein sequence ID" value="SEF44232"/>
        <property type="gene ID" value="SAMN04489712_10135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF44232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="473" mass="51145" checksum="922F9E7DDA72D3B1" modified="2017-01-18" version="1" fragment="single">MSGVIDPGAIPIPKADPDAVETAGRALGGDGTAIAGTGHDIHTGWQRLRGAYEAPEAPQLFAATQPVETTGNAFRDEVATVGGALVSFAGEIRPIIGRLQSLKTSAQNFRNGIAGDDDWREDEDKVTEHNKLNNDVLAAVAQYQDAERRCANKITAIFGGTHFVPADGNPGQGQQGYGLGQAPTDVETPWAKPQEHDKPWYQDVWDGVWDFGEGIITDLADLVGLHGANGWVWEEDSDWTDNLQGNWMQVVRDVSGLIGLHGENGWVWEEDSHYWSNLGHNWKEVVHSFVPWREWDDRPGYVITQSVLNIGSLLIGVGEVKLALKLLKRGDVDAPRPRDRGDADGDGRLDHDELDTPGQDAPTTRDLQDRLDQLDFDTQDLDNLQDQLDQAADLREHEPAHVGGNDRPDTDGGGHDVGGHDDQGDQGEPGDQGDQGDGQGPTSPNDEVPDDDGRDTGTDPDADASDGGQDTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S626</accession>
    <name>A0A1H5S626_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR03083 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45231">
        <property type="protein sequence ID" value="SEF45231"/>
        <property type="gene ID" value="SAMN04489712_10168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="156"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF45231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="29299" checksum="62C65020CC2296EF" modified="2017-01-18" version="1">MGGPIHGRRWAHARYCDAAEAEIAAFAAAVREADPAAPVPTCPGWSVADLVLHLGRTHRWAHALVDRLSPGNLRHRDIDMDFPADRRDPAGYLPWFDAGAAALLGALRRADPQAVMWSWGADRRVRYWSRRMLHETAVHRCDAEFAAGRDPVLDEEVAEDAVDELLDNLPYAASWAPHVERLRGAGETIALVSSGTGTRWLIRLEPGGFSWSRTAEEETKATASVRGTASDVDLFLWGRRKLGDPRLEFAGEDALLIHWVENSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SAP0</accession>
    <name>A0A1H5SAP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46877">
        <property type="protein sequence ID" value="SEF46877"/>
        <property type="gene ID" value="SAMN04489712_101115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF46877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="29479" checksum="F05D935288D7DD39" modified="2017-01-18" version="1">MKRRGNGLDADSYAPLIDLAPHLADTMLEALREAGVAAYVTPTPDPDETGPRITGTDGDSLDRLYVDTAMQSAAEGILHTHLTRLRAADGDPADGPDPDSGPADPGAVDPSPRGRAEPRPADSVAGTTAERDEDAIWAEIVAGFDTVPADGETPWPEQENIDEPPAGRAQPGPADEGEDRAGLLPISRVIKPADDPEPPPPDDEGHYVPPPPPPLPSTDPITKTAWLCLVGGPLYLLVTVILGWSVPGWAAFLAVAAFIGGFVTLVLRMGDDPHDTDDGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SE93</accession>
    <name>A0A1H5SE93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">SAMN04489712_101171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48825">
        <property type="protein sequence ID" value="SEF48825"/>
        <property type="gene ID" value="SAMN04489712_101171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF48825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="20061" checksum="5AE4836FD2BB0C51" modified="2017-01-18" version="1">MAVKPIRLFGDPVLRTPAEPVKDFDKELRNLVKDLTDTMIDAPGAGLAAPQLGVGLRVFTYYVDDRLGHLVNPTLDLSDEQQDGEEGCLSLPGLSFPTPRAWRAVAKGFNMYGEPITLEGTDLLARCVQHETDHLDGILFIDRMDPEQRKAAMKAIREAEWFGEPAPVIKESPHRTLGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SEC0</accession>
    <name>A0A1H5SEC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48976">
        <property type="protein sequence ID" value="SEF48976"/>
        <property type="gene ID" value="SAMN04489712_101176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF48976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="23087" checksum="BAD6FC0DE0D348C8" modified="2017-01-18" version="1">MASVENPPAVHLPAAALLLDVDGTLIDSTPVVERAAHRWAAEYGLDPQEFLADAHGRRTADRVAEFVPPGRVAEATARLDELEASDTEGVVALPGVLDLLAALDGRPWALVTSMDRPLLDVRRAAAGLPLPEVVVTAEDVRQGKPDPEGYLLAARHLGVAAGECVVIEDAPAGIRAGRAAGARVVAVTTSHPAAALTEADMIVSDLTAVSVTAGGLLVSGNGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SF63</accession>
    <name>A0A1H5SF63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="15">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">carB</name>
        <name evidence="19" type="ORF">SAMN04489712_101160</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="15">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="15"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48441">
        <property type="protein sequence ID" value="SEF48441"/>
        <property type="gene ID" value="SAMN04489712_101160"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 15" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="139"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="689"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="18">
        <location>
            <begin position="963"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="15">
        <location>
            <begin position="1"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="15">
        <location>
            <begin position="963"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="840"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="852"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="854"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SEF48441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1114" mass="119518" checksum="91FC250C44A98910" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T0R7</accession>
    <name>A0A1H5T0R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56423">
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        <property type="gene ID" value="SAMN04489712_101438"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:organic acid catabolic process"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
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        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="161"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF56423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="284" mass="29267" checksum="455A7559373A982C" modified="2017-01-18" version="1">MTTAGFVGLGNMGGALAANVARAGLPLVAYDAAGPERTPEGAEYAADVAEVARQADVVVFSLPDGTVSEQVAREIVAVADRRVTHVVDTSTVGVRAAQDIAALLAGSGIAYVDAPVSGGVAGARARTLAVMYAGTDEACAHVEPVLTGLSDRRHRVGDRPGLAQALKLANNFLAATALAATSEAIAFGVSVGLEMDTMLEVLNGSSGRNSATSDKFPDHVLTGRYAAGFANSLMSKDVQLYLRAVADRDGPSSIATVTASLWERFAEAEPGADFTRIFPFVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TLU4</accession>
    <name>A0A1H5TLU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-lactate dehydrogenase complex protein LldF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63733">
        <property type="protein sequence ID" value="SEF63733"/>
        <property type="gene ID" value="SAMN04489712_101671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF63733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="496" mass="53136" checksum="A5226E11CEE168DB" modified="2017-01-18" version="1">MTSGPIPLPMPRVLGALGGTGPGEAARPRFATAAREALADTGQRRSLRESMAVLRGRREAATAEAADWEELREAGRAVRDRSLLSLDTHLETLEGAVTDAGGTVHWAADAAEARRIVVGLVRATGRSEVIEVRSPVTREIGLDRALAGAGVDVAETGAADLAVRLAGERPAHFLLPAVHRDPAEIRRTFLRRMPGAPSDLTDDPRELADAARAHLRRRLLSADVAVIGAAFAVAETGTLVMPEGDGGGRMCLTLPETLICVLGIEQVVPCWRDMEILLQLLPRSATGERMSPYVSTWTGVSAQDGPRDLHVVLLDNGRTAALADEVGRAALRCIGCAACLSVCPVYERTGGHAYAAGGSVLSGPIGAIWTPQTRGVRGAAEASLPFASTLCGACGDVCPVKIDIPGILVHLRGKVVQARRHRPVPPPEMAVMRALAWAMGDRRRYEPALRQGVRWARLLSRGGRIRRLPGLLGKWTEARDLPAPPRDPFRVRWRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TR99</accession>
    <name>A0A1H5TR99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase, activator-dependent family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65313">
        <property type="protein sequence ID" value="SEF65313"/>
        <property type="gene ID" value="SAMN04489712_101717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="DUF1205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030953">
        <property type="entry name" value="Glycosyl_450act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="DUF1205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04516">
        <property type="entry name" value="glycosyl_450act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1205" evidence="4">
        <location>
            <begin position="217"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF65313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="432" mass="47800" checksum="FD5AE603FD3233AB" modified="2017-01-18" version="1">MRVLFVTLPTKAHAFAQVPLAWALRAAGHEVCVASQPELVDDITRTGLTAVPIGPELDQAGMVEENRRQREAAEQADLDVPDPELLLKLDGLPPEAVTYDYMQGLFTVMTTLAFKALSPQHAMDELVRFAREWRPDLVVWDTLVLAAPVAAKACGAAHARLLYSLDLLGRMRERYQSELARRPVEVWDDPVREWLESTLDRYGCGYSEDLMLGQWTIDPVPSSMRLPVDLPYVPVRFVPYNGRAELPGWLRRSPERRRICLTLGLSFREMLGGDRVSVAELLDAVADLDVEVVATLNAEQLAGVDKVPDNVRAVDFVPLNELLPGCLAIVHQGGFGQVQTAMAHGVPQVVLPNGTWDTVPRAWQVQDFGAGLVVDDPDRVSAAEIREKVVRVLQEPGFAVSAARLREEMLATPAPAEIVPLLERLTAEHRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TUP8</accession>
    <name>A0A1H5TUP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p450-derived glycosyltranferase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66602">
        <property type="protein sequence ID" value="SEF66602"/>
        <property type="gene ID" value="SAMN04489712_101756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030958">
        <property type="entry name" value="P450-rel_GT_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04515">
        <property type="entry name" value="P450_rel_GT_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF66602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="425" mass="45931" checksum="FE50562079C85EAC" modified="2017-01-18" version="1">MDKDLATGMADHELSYLLLLMHGAQWIMGVKDDPYALLLRAASDDPHDLGRRMRSRGPLYRSHAAVWVTAHHDLAAAALSDARLGPEYAAPQEPDEARAERERVLPFDLPRMEQLLPLGQASLTLGRPACERLRALTRAVLDGVEDLAADLCARRVRTLDGDFDLRDDLARPVAVAAVAEVLGLRASDGERFAELCAGTDGALDATLCPPLLAPARRLTAAITGMRELLDGSLRRNGGSTGRLVDAAVGEGRSLDDALAACVSLAVVGVDMAINLVCDAVQALLDHPEAWERVRDEPACAALAIEETMRYAPPVRLHRLFSHEDVELGGHKVRVGDEVVVVVEAAERDPAVYDDPDRFSLERGGRAALPDGPLTEPAGPPARRMAAATLRTIADELPRVRRTGPVLRRPRSPITRGVLRFPAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TYW6</accession>
    <name>A0A1H5TYW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monosaccharide ABC transporter substrate-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68062">
        <property type="protein sequence ID" value="SEF68062"/>
        <property type="gene ID" value="SAMN04489712_101803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009285539" evidence="1">
        <location>
            <begin position="22"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="42"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF68062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="325" mass="34540" checksum="6A0601410FA6F277" modified="2017-01-18" version="1">MFKRLILAIAGVSLALTAVTACGGSDGGSTGSNSDTLVLGFSQVGAESGWRTANTLSIKEAAKTAGVDLKFSDAQQKQENQIAAIRSFIKQKVDVIAFSPVVVTGWDAVLKEAKAADIPVILTDRAVDSDASLYVTFLGSDFVEEGRKAGQWLVDEYKDAKEPVNIIQLEGTVGSAPAIDRKKGFEEAIAANPNLKVVASQSGDFTRAKGKEVMQALLKANKDVDVLFAHNDDMGLGAMQAIEEAGRTPGKDVKIVTIDAVRDGMQALADGKFNFIVECSPLLGDQLMATAKKVKAGETVDKRIVTVETVFDQAKAKEALPTRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U2I4</accession>
    <name>A0A1H5U2I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid/amide ABC transporter membrane protein 2, HAAT family /amino acid/amide ABC transporter ATP-binding protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_101845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69230">
        <property type="protein sequence ID" value="SEF69230"/>
        <property type="gene ID" value="SAMN04489712_101845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="374"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="406"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF69230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="628" mass="66674" checksum="5442FCC77030EAFD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UV56</accession>
    <name>A0A1H5UV56_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvC</name>
        <name evidence="12" type="ORF">SAMN04489712_10242</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78886">
        <property type="protein sequence ID" value="SEF78886"/>
        <property type="gene ID" value="SAMN04489712_10242"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="183"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF78886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="330" mass="35810" checksum="5A0FAB1790647C7B" modified="2017-01-18" version="1">MAEMFYDNDADLSIIQGRHVAVIGYGSQGHAHALSLRDSGVDVRVGLKEGSASREKAEADGLRVVTPAEAAEEADLIMILAPDHVQRDLYNNEIRPALVEGDALFFGHGLNIRYGLIEAPQGVDVAMVAPKGPGHLVRRQFTAGRGVPVLVAVENDASGNAWPLVLSYAKGIGGLRAGGIKTTFTEETETDLFGEQAVLCGGVSELIKAGFETLIEAGYQPEVAYFECLHEMKLIVDLMYEGGIQKMYWSVSDTAEYGGYTRGPRVITAETKAAMKQILAEVQSGEFARELVAEFDGGQVNHLKYREELGNHPIEQTGAKLRPMMSWLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V1H5</accession>
    <name>A0A1H5V1H5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hercynine oxygenase</fullName>
            <ecNumber evidence="1">1.14.99.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtB</name>
        <name evidence="4" type="ORF">SAMN04489712_102123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O</text>
            <dbReference type="Rhea" id="RHEA:42672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="EC" id="1.14.99.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EgtB family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.50" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81074">
        <property type="protein sequence ID" value="SEF81074"/>
        <property type="gene ID" value="SAMN04489712_102123"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044875">
        <property type="term" value="F:gamma-glutamyl hercynylcysteine sulfoxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02035">
        <property type="entry name" value="EgtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032890">
        <property type="entry name" value="EgtB_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="3">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="184"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Gamma-glutamylcysteine binding" evidence="1">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF81074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="447" mass="50861" checksum="C60168E930ADFCD5" modified="2017-01-18" version="1">MAPLTTTDGLDEHGLKELIAAELDAVRDRSLGLTTEVLDAAELTAQVSPLMSPLVWDLAHIGNYEELWLLRAAAGVEPMRPEIDSLYDAFEHPRAERPSLPLLPPEEARAYVATVRARVLDSLPKVRLREDDPLTAGGFVYGMVVQHEHQHDETMLATHQLRKGAPALLEPDGPVPPVRDPAIPPEVLIEAGPFEMGTSDDPWAYDNERSAHIVDLPAYYIDTTPVTNHAYIAFIEAGGYDDARWWHPQGWEWRSAKGRRAPGFWTREDGQWLRRRFGRVEPVPPDEPVQHVSWYEADAYARWAGKRLPTEAEWEKAARWDPDAQRSRRFPWGDFYEEGRANLGQRRLRPAPVGSFPRGVSAYGVHQMLGDVWEWTSSDFAAYPGFRAFPYREYSEVFFGPEYKVLRGGSWATHPLAVRGTFRNWDYPIRRQIFTGLRCARDATEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V3F7</accession>
    <name>A0A1H5V3F7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Allantoate amidinohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">alc</name>
        <name evidence="5" type="ORF">SAMN04489712_102129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81268">
        <property type="protein sequence ID" value="SEF81268"/>
        <property type="gene ID" value="SAMN04489712_102129"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="PTHR12045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="4">
        <location>
            <begin position="190"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF81268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="37140" checksum="A785BC31B1C1229C" modified="2017-01-18" version="1">MIENGFTALPDLAVRSLGGSVVAASDEAFAVKENLVNPWAPTFSPGTFGPRGQEYDGWETRRRRPDARGELGHDWAVVRLGLPGVIRGVVIDTAWFRGNFPPLASVEACAAEGYPAPDELAGWVEIVPRSPLEGDRAHFFPVEVERRFTHVRLNVFPDGGVARLRVHGEVVPDPRPLAGLTVDLAALENGARVTGCSDEFYSSPGNMLFPGLARTQAEGWETARRRGAGNDWAVVRLAAAGVVRLAELDTGNLRFNAPGWASLSGMDERADPGRWFPLLERTRLQPDLRHRFRIEDAPETTHVRLDVHPDGGMARLRLLGDLSPSGARALRERWARLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V4D5</accession>
    <name>A0A1H5V4D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82169">
        <property type="protein sequence ID" value="SEF82169"/>
        <property type="gene ID" value="SAMN04489712_102160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF82169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13558" checksum="445F6D7307F4802B" modified="2017-01-18" version="1">MEWTEPGPVVRPYALTGGRTRPAGGDFDLIAIIETAAGSGGDADGPPGTAGIERLPRSPEHRTILELCRSPLSVAEVASELDLALGVVRVLLGDLLDHGLIRVRRPAPVAQFPNERVLKEVIDGLHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V509</accession>
    <name>A0A1H5V509_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82290">
        <property type="protein sequence ID" value="SEF82290"/>
        <property type="gene ID" value="SAMN04489712_102164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="150"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF82290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="399" mass="42277" checksum="1810F9B32A43583E" modified="2017-01-18" version="1">MSGGDAPALGIGMVGHAFMGRAHSQAWRSVRAFFDVPCVPVMAALAGRDAERVRRAADRLGWASAETDWRALLRRDDVQLIDICAPGDTHAEIALAALGAGKHVLCEKPLANTVAEAEAMAAAAERAAARGVRAMVAFNYRRVPAVALARRLVADGRLGTVRHIRAQYLQDWLADPEAPLSWRLDRERAGSGALGDIGAHLVDTAQFITGDRLIGVSALLETFVTERPLATASAGLTASAGTERGPVTVDDAALFLGRTAGGAVALFEATRFATGRKNALRIEVNGSRGSLVFDFEAMNELWFHDHTLDGGEAGFRRILVTEPSHRYAAAWWPPGHLLGYEHTFTHEIADLLSAIAAGTDPSPSFADGLQVQRVLAAVEDSAAGGGGWTPVPFEDAPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V9K9</accession>
    <name>A0A1H5V9K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84019">
        <property type="protein sequence ID" value="SEF84019"/>
        <property type="gene ID" value="SAMN04489712_102228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF84019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="33169" checksum="6FA63A73606DC7EF" modified="2017-01-18" version="1">MGWHITEDLDEYLAAAGDFLWADPTLHTVELGVIEALRVHGTDLYGGEPALFGWWRAGTGPVSGALLRTRPYPALLSGVPPAAAGDLAEILADQRRTLAGVVAERPVAHGFARTWRRRTGTTAKETRRQRLYRLERLDMPSPPPPGAARIAGPADLDLVTAWHRAFGAEAHEGGARIPARLIEDKIAYGGVALWEADGVPVSMAARTPLVSGMARVAPVYTPSEHRRRGYGAAVTAALTRWTLDAGARDVVLFTDLANPTSNAIYRRIGYRPVIDRLELSFHRDGPSPETSTETSLPPEDFHGDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VLW8</accession>
    <name>A0A1H5VLW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol maleylpyruvate isomerase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87537">
        <property type="protein sequence ID" value="SEF87537"/>
        <property type="gene ID" value="SAMN04489712_102349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF87537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="214" mass="22615" checksum="938A964D0B416396" modified="2017-01-18" version="1">MPEQPMSQTYLEVAASALTLLSDPAVAGAWRAPSALAGFTVGGLAEHLATQIFSVRAGLAAPWPDHEVIGLLDHYSRVSWLGADLDAEANVAIREGGEQSAAEGPQALVGRADAALAELRDLLPALPADRPLSINRYAWALRLEDVLVTRVMELAVHSDDLAVSVGVPTPSLPPQAVERVTDLLTRLAVQRHGPTAVLRALSRAERAPTSISAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VM60</accession>
    <name>A0A1H5VM60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88425">
        <property type="protein sequence ID" value="SEF88425"/>
        <property type="gene ID" value="SAMN04489712_102378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009287383" evidence="2">
        <location>
            <begin position="25"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="116"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF88425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="358" mass="38314" checksum="0310A65FE1066E3C" modified="2017-01-18" version="1">MRRTLALGLVAGVLASGCSVRTLGAPKGDLTLVATFDDTQQLVTGHSVQMSDVKVGSVTGVRLVAGYKAEVTMSIRDEYRIPQGTSAEIKVTSLLGENFVDLRLPPGQNMSTGPFLRSGDRIAKTSTQPSFEQVVGRAGPLVNALAGDDLSKIVNAGASALGGNGPKLNAAVAKSAELLEMFAGQRAQLTTAVDEFARLGRSLARGSADLGRAPAELERTTRMLNQNAEEILATVEKLTRTARLLGDRVLEGRVLTLKRLIQQVDPVLEMLAGDRQRLGNLVDGIEVFTRELPRATYDGQLLLYPLLRFVLDDGTILPRPTDGSPTTLGGRRNQASDPVPGKVRDAMPNLDDILERPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VUV0</accession>
    <name>A0A1H5VUV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Very-short-patch-repair endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91075">
        <property type="protein sequence ID" value="SEF91075"/>
        <property type="gene ID" value="SAMN04489712_102472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF91075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="281" mass="31531" checksum="6BBCDDFDA230ED54" modified="2017-01-18" version="1">MERPSPSDVLTARVRSLASVLPAHAVFAERTAAWLWGVDASSMGVGRADRPIELAVPAGRASPDIPGCRTRGGHLPAEDVTYLDGVRVTTRERTALDCARWLPRLEAIAALDQFLRAGTDAALLRRRMRLLTGETHARRLREVLTLADAGAMLPGETYTRIRVMDAGLPRPRTQIPVPSSGRPRFFLDMGYEDHLTAVEYDGEEFHTARAHCRRDAARRTWIREHHGWEIIVVTKEDVLFNPAPFLETLTTILMHRGWSPAPARLDRIAAKLTRLRRHRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W2T6</accession>
    <name>A0A1H5W2T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93795">
        <property type="protein sequence ID" value="SEF93795"/>
        <property type="gene ID" value="SAMN04489712_102568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
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        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF35_N" evidence="4">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="3">
        <location>
            <begin position="60"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="2">
        <location>
            <begin position="254"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF93795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="589" mass="61997" checksum="06BD4652C82EFC2D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W345</accession>
    <name>A0A1H5W345_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93929">
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        <property type="gene ID" value="SAMN04489712_102572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF93929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="385" mass="40884" checksum="01F6EB40AE1B128A" modified="2017-01-18" version="1">MGNPCAVIGVGQTAYKTKRLDVSMAGLLREAAQRALEDAGLDWADIDAVVIGKAPDLFEGMMMPEAYLADALGARGKPMMRVHTAGSVGGSTAIVAAGLIQSGVHDRVLTVAWEKQSESNATWALTVDSPHSTSLVVGAGGYFAPHIRAYMRRSGAPDHIGTLVAVKDRQNALKNPYAHLKIPGISREMVESTPMLWEPIRYLETCPSSDGACAMVLASESAARSAPNPPAWVQGTSMRSEPIFFAGRDNVLPQGGRDAAADVYRQAGITDPRRELDCAEVYVPFSWYEPMWLENLGFCGEGEGWKLTEAGATALDGDIPWNPSGGVLSSNPIGASGMIRFAEAALQVRGMAGEHQVDGARRALGHAYGGGAQFFALWIVGSDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WXM8</accession>
    <name>A0A1H5WXM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthase domain TIGR01720/amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04073">
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        <property type="gene ID" value="SAMN04489712_1031"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="972"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2077"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1007"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="2918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG04073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="2918" mass="313335" checksum="F8B97E96892D215F" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X1M4</accession>
    <name>A0A1H5X1M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05799">
        <property type="protein sequence ID" value="SEG05799"/>
        <property type="gene ID" value="SAMN04489712_10357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043746">
        <property type="entry name" value="DUF5691"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18944">
        <property type="entry name" value="DUF5691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG05799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="599" mass="64097" checksum="684F222274B618F0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X2A6</accession>
    <name>A0A1H5X2A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05878">
        <property type="protein sequence ID" value="SEG05878"/>
        <property type="gene ID" value="SAMN04489712_10359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG05878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="798" mass="86600" checksum="8A2E463FA3A451A6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XGW7</accession>
    <name>A0A1H5XGW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, LacI/PurR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="66"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="339" mass="36445" checksum="7C4F268F814F8904" modified="2017-01-18" version="1">MGVRRSRAQARPTLEEVAALAGVGRGTVSRVINGSPKVSAQARQAVQAAIEELGYVPNRAARTLVTRRTDTVALVLSEGEQRLFEEPYFADIIRGISSALNETGLQLMFTLAQTPRDHERLEQYLTGHHVDGVMMISLHAEDPLPGLLADHGVPTVLGGRPVGVGAERVSYVDADNEGGARKAVEYLVAQGRRRIATIAGPQDMGVGIDRLNGYRAALGDLPEQVVTADFSEAGGRAAMRELLARDPELDAVFVASDNMAMGALRTLREAGRRIPGDVAVIGFEDSAAQRAEPPLTSVHQPTERMGREMVQLLVARIRGERTEPTGVIVDTHLVVRDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
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            <taxon>Actinobacteria</taxon>
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                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 43163</strain>
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    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="SEG13933">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="151"/>
        </location>
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        <location>
            <position position="46"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG13933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16548" checksum="A51B0F9F732B5410" modified="2017-01-18" version="1">MAVEVGDVAPDFELTDQHGTPVRLSDHRGEHNVVVVFYPLAFSGVCTGELGAIRDALPSLGEDARVLAVSVDSMFAQRAWADREGYAFPLLSDFWPHGEVARAYGVFDAERGVAVRGTFVIDREGVVRWKVVNALADARDIDEYRKALATL</sequence>
</entry>
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    <accession>A0A1H5XW94</accession>
    <name>A0A1H5XW94_9ACTN</name>
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    <reference evidence="3" key="1">
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                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
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    <dbReference type="EnsemblBacteria" id="SEG15805">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="93"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG15805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="605" mass="64849" checksum="EA7A25032A68B8DE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZ01</accession>
    <name>A0A1H5XZ01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SseB protein N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16496">
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        <property type="gene ID" value="SAMN04489712_103460"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="365"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG16496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="833" mass="86363" checksum="7F7AA15351DEB5C7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y228</accession>
    <name>A0A1H5Y228_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17845">
        <property type="protein sequence ID" value="SEG17845"/>
        <property type="gene ID" value="SAMN04489712_103511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG17845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="401" mass="42947" checksum="496BAA6F39321AE8" modified="2017-01-18" version="1">MGIEVVVEGLSKSFGRQTIWQDVSLTLPAGEVSVMLGPSGTGKTVFLKSLIGLIKPERGRVMINGVDMVSSSERRLHEIRKLFGIMFQDGALFGSLNLYENIAFPLREHTKKKESEIRRIVLEKMDMVGLAGAEGKLPGEISGGMRKRAGLARALVLDPEILLVDEPDSGLDPVRTAYLSQLLIDLNAQIDATMLIVTHNIDIASTVPDNMGMLFRRGLVTFGPREVLLTSEEPVVFQFLRGRRAGPIGMSEEKDAATLAMEQAQGYPDEEDDGPFKIPRQLRPSPGMPPRKGAERRRERVLGMLHQLPPPAQQAILENMNAEAQRPVGVAPELPQRSAAKGSYGPAPAPGHGPAAGPVPSPRPAPGPRLLPPDPPPGPPPAGPSGPSGPSGPPPGEGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YGT6</accession>
    <name>A0A1H5YGT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23248">
        <property type="protein sequence ID" value="SEG23248"/>
        <property type="gene ID" value="SAMN04489712_1045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="11706" checksum="690877DCAACF2E4B" modified="2017-01-18" version="1">METPARRGKSWTFLTNHARVLISIARRPTIRVRDVAQEIGITERAAQLIITDLEEAGYLTRTRVGRRNTYTVNAERPFRHPAEADHDVRDLLALFTDQSTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YPA2</accession>
    <name>A0A1H5YPA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25196">
        <property type="protein sequence ID" value="SEG25196"/>
        <property type="gene ID" value="SAMN04489712_10487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG25196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="12761" checksum="899B3CA523FF88DA" modified="2017-01-18" version="1">MSMELPSSSRMDQVAAALRQISEGFAALADAISADPAEVPAESRYRSLISEWGARGLTRSEASALFRKHGFSPQVAGGWARGDWLEIRDDGLRYLTDRSFHWLAEQGASDDPQPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YWU0</accession>
    <name>A0A1H5YWU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28783">
        <property type="protein sequence ID" value="SEG28783"/>
        <property type="gene ID" value="SAMN04489712_104238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG28783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="239" mass="25580" checksum="BFEC0EBC03F2482F" modified="2017-01-18" version="1">MDSVTESDYEEPPYWRRRALVLAGLLAVVGLLVWTCGGGDDRRSGVAGAAGTPSPSSSPEPSGRIPVAAPTVTVTATAKTAATPTPTAKTTTKAPAKAQTGAAPRKDIPKDKDACERGDVVAGFSMDGDDYARGTLPQFRVSVVNTGERTCAFRTDPRALRILITSGQDRIWSSDHCVRGAGAPVRLRRGVPQVRTVTWDRRRSAEGCPRLRPAARPGTYVAELRGDGVKTRRLVFRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZED1</accession>
    <name>A0A1H5ZED1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-monoxide dehydrogenase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34424">
        <property type="protein sequence ID" value="SEG34424"/>
        <property type="gene ID" value="SAMN04489712_104498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="786" mass="85103" checksum="7A1D622D399CC43D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A0H6</accession>
    <name>A0A1H6A0H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41852">
        <property type="protein sequence ID" value="SEG41852"/>
        <property type="gene ID" value="SAMN04489712_105103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG41852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="31591" checksum="42A2AFC21F355122" modified="2017-01-18" version="1">MSGIEERIERAFRDAGVVGCLAAIDLDDGRLVGVRADRPVVIASVLKVPLLVALHRQAAAGIVDLSEQVVLRPGERTTGPTGVAVLQDEVRMSLRDLAAMMITVSDNAAADTLFARVGVETVNAVLAELGLHRTHIPGCCRELFDTLLADAGVDGMDELWAVLDEPGLMARLRALDPARTARSTPEEIAQLFAAIWRDEAAPAAECARMRRLFGLQVWPHRLASGFPFDDVQVSGKTGTLPTIRNEAGVVEYPDGGRYAVAVFTRSLSTASVLPRADAVIGTTARMAVEHLRAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A286</accession>
    <name>A0A1H6A286_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42520">
        <property type="protein sequence ID" value="SEG42520"/>
        <property type="gene ID" value="SAMN04489712_105143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG42520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="29546" checksum="5D2A1F4680BBBFFC" modified="2017-01-18" version="1">MSGSGKRGKTADTVGRQIVIWSIVLGVIGLIVVLVVADNNDDEVGFSGGGLFGSEGAGRLVERLNAAAGAQQICYGWEIDSDLPGMTDYITPVTPSAPALRTPAPGATPLPTPAPGTPQSETEQRLRDTLAAEPGVDVGSNLGTGVDPRERPQECPRWVVFTADYYYDITEEEWTSVTQGIETNLPLQLSPSDLRQAGITEVDLLGDQANARLADAVGALPMIVAEKGAAPPVPQIDVQAPPAGDKISPPGMARYVWMGIGGVLVAGGLVWIVIAAVRSRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AAQ4</accession>
    <name>A0A1H6AAQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45380">
        <property type="protein sequence ID" value="SEG45380"/>
        <property type="gene ID" value="SAMN04489712_105299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG45380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="10926" checksum="3C7834D99818DB44" modified="2017-01-18" version="1">MGRSELELAEEFNLRMRAVVLLRRVSADQPVTSQQTAVLGSLTDGGPPRARGRASRCRGRAERRRSRHRLSSQAVPLSLAMRFSYFRNRGLCDLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AB21</accession>
    <name>A0A1H6AB21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45908">
        <property type="protein sequence ID" value="SEG45908"/>
        <property type="gene ID" value="SAMN04489712_105331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="167"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG45908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="364" mass="40471" checksum="B883DE607450F26E" modified="2017-01-18" version="1">MSDVFPVKGMDAVVFAVGNAKQAAHYYSTAFGMRRVAYRGPETGCPDEAAHVLESGGARFVLRGPVRAGTDLGRHVADHGDGVVDLAIEVPDVEAAYRHAVAQGARGIEEPYALEDEHGKVMLAAIATYGQTRHTLVDRSNYSGPYLPGYVAAEPIVEPPAKRFFQAIDHCVGNVERMDEWVDFYHRVMGFTDMAEFIGDDIATEYSALMSKVVADGTRKVKFPLNEPAEGRRKSQIEEYLEFYGGPGVQHIALATNDILASVDRMRAAGVEFLDTPDSYYDDPELRARIGQVRVPVEELRKRRILVDRDEDGYLLQIFTKPVQDRPTVFFELIERHGSLGFGKGNFKALFEAIEREQARRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AC96</accession>
    <name>A0A1H6AC96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NitT/TauT family transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46338">
        <property type="protein sequence ID" value="SEG46338"/>
        <property type="gene ID" value="SAMN04489712_105359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292527" evidence="1">
        <location>
            <begin position="25"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="36418" checksum="593C2EABC4CEFA92" modified="2017-01-18" version="1">MLRTLKRRTVAAALLLFAGTGALAACGGSDDDGGSGGGDGQLKLGFFPNITHATALVGVDKGIFAKHLGTAPKTATFNAGPAAVEALFAKGVDATFIGPNPAINAWAKSKGQGIKIISGAASGGASLVVKPEIKSIEDLKGKKIATPQLGNTQDVAARSYFKSKGLTANKDGSGDIKIVPQENSQTIDTFKQGAIDGAWVPEPFASRLILESGGKELLNEKDLWPGGKFVVTHLIVRTDFAKEHPDTVRKLIEATVEATDYINTNPDEAKKSVNAQLTKLSGKPIKDDVLDAAFKNITFTTDPVASSLLTGAKNAEAVDLLEPVDLNGIYDLTTLNEVLKAGGKAQVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXH0</accession>
    <name>A0A1H6AXH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Shikimate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53054">
        <property type="protein sequence ID" value="SEG53054"/>
        <property type="gene ID" value="SAMN04489712_10670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG53054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="25327" checksum="E03FBBDFC27A5BCD" modified="2017-01-18" version="1">MHSAPNERTSPDARRERLRHVHWIGGGSGSGKSTIAQHIADRYGMRLYDTDAVMPDHARRMSVEQAPHLARFAAMDMDERWVARSPREMLDTFHWFHGEGFDLIIEDLLALPADRPVIAEGFRLLPGLVRPLLADVSHAVWLLPTPRFRQAVFDSRGGPAWGFLAKTSAPRQALRNLLQRDALFTDRLTEQTRHLGLHGLRVDSTTTEEDLVRQVSALFGLEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B288</accession>
    <name>A0A1H6B288_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54445">
        <property type="protein sequence ID" value="SEG54445"/>
        <property type="gene ID" value="SAMN04489712_106157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="244"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG54445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="43999" checksum="76368F6D859FA608" modified="2017-01-18" version="1">MTTAFTDTAPEAKAQPRDHDGWLVLAREVAAELAEDAAERDRAGRPPFEEIEYLRTAGLLTLLIPAERGGGGATWRTAYQVTREIAAADGGIGQLLGYHYLLSWNLHFFGSPQLQERVERQAAAARWLWGGAFNPRDPDLTLTPRPTGGFELNGTKTFATGARVGDRLAVGATRADTGEPLVVIANPLHPGVTRPDDWDNIGQRLSASGSVSFAAVPVAAEDVIGSLENPSPWVTLVTPAIQLVFVQFYLGIAEGALASARDYTRTTTRPWLLSGVERAVDDPYVLATYGELVARLRAARALADQAIEEIEPALHGPGREDLTEERRGELAVLVATAKVAATEASLTVASRIFEVTGARSTRAALALDRFWRNARTHTLHDPVAYKQREVGAHFLTGEFPPFTLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5B8</accession>
    <name>A0A1H6B5B8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_106278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56028">
        <property type="protein sequence ID" value="SEG56028"/>
        <property type="gene ID" value="SAMN04489712_106278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG56028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="592" mass="62537" checksum="C5778DB0633D57B7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLS4</accession>
    <name>A0A1H6BLS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_107229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61623">
        <property type="protein sequence ID" value="SEG61623"/>
        <property type="gene ID" value="SAMN04489712_107229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293870" evidence="4">
        <location>
            <begin position="32"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG61623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="26500" checksum="E82F72A2742BD1CA" modified="2017-01-18" version="1">MPLRPLLRRLAACAGVLLLAPAVAGCGESSAPVTLTVFAPPSLTEVFTELGAVYGRSHGVKVRLVFGGSPELVERLRERQRADVLVTGDETAMQTAAKYVGARRIVARNSMTIAVAPGNPREIHGVTDLIRPGLRVVLGSSTTPVGRYARQITAKEGLTVRASSEEISARAVLTRVRTGEADAGIVYITDMRSAGAAASSVPIPADQNVTVAYPAAPVLNSDHPEAARTLFTWLTSAQARPVLHRHGFVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BVG1</accession>
    <name>A0A1H6BVG1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrA</name>
        <name evidence="16" type="ORF">SAMN04489712_10848</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64711">
        <property type="protein sequence ID" value="SEG64711"/>
        <property type="gene ID" value="SAMN04489712_10848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="613"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="744"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="645"/>
            <end position="652"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SEG64711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="946" mass="104226" checksum="BFD050D178E2A0F1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZR3</accession>
    <name>A0A1H6BZR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65626">
        <property type="protein sequence ID" value="SEG65626"/>
        <property type="gene ID" value="SAMN04489712_108121"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="UCP07580"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="311" mass="35368" checksum="FE402A41B9A2BFBC" modified="2017-01-18" version="1">MTRPLGAQGAAWEIDERHPPIKTRRVSFDWEKTPLHWIPGNPVATHMINSFHVVLPEGEKWFINCVKAATPYVTDERLRREIKGFIGQEMVHSRSHQGVLDGLLAANGIDVTVVTEPAGRGNAEWPAKMAELRKRRPRLYRRRLLFELGAVAAIEHYTAVLGQWIMDNDRLDAAGVDPTMLDLLRWHGAEEVEHRSVVFDVYRHLGGGYLMRVASWMVALFFLYWALIGGTLLFLRQDPTVRGKVTLPRVYRSYRRSVRRGLVPGIFTLLLGEAPVYLRPSHHPSQVCSTPQALEYLMRSPAARAAGYDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C0X4</accession>
    <name>A0A1H6C0X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66036">
        <property type="protein sequence ID" value="SEG66036"/>
        <property type="gene ID" value="SAMN04489712_108159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHTETR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG66036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="216" mass="24474" checksum="A15252599EDB6C99" modified="2017-01-18" version="1">MAPKTDRRTQHSEESRRRILQAAAEISAERGYDGTSVALVTKRSGLPASSVYWHFGSKDELLAEVVEHSYRQWLPRKARWAPPEPGTDRVAYLRDALRQAGASFADQPEFMRLGLMLLLERRAEEPAARVRFKRIRAEMLDAMSEWWEAMLPEEVNASHPHLPRMLAQLNMAAADGLYMMSVGDPEEIDMNGLQELLALALDAVADRIARQVYGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1Q0</accession>
    <name>A0A1H6C1Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted Zn-dependent protease or its inactivated homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66286">
        <property type="protein sequence ID" value="SEG66286"/>
        <property type="gene ID" value="SAMN04489712_108179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="225"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG66286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="464" mass="49095" checksum="07887E95658E24E1" modified="2017-01-18" version="1">MTPQESVERALELSRADECVVIADESSTANLRWAGNTLTTNGVTRSRRLTVIAMRRAGDGVATGVVSRTAVGADEIEDVVREAERVAADSGPAEDAAPLASGGPAAGGAWDEPPTETEIGVFATVAPALGEAFAAAQAAGHRLYGFANHQLTSTFLGTSGGLRLRHDQPTGLVELNAKLAGAAGGGSAWTGMSTRDFTDVDVPALADELARRLEWSRRRVELPAGRYETLLPPSAVADLMIYLYWTAGARDAHDGRTVFSAPGGRTRVGEKLADLPVTLSSDPHAAGLQCAPFVIARASGRDSSVFDNGLAVPATNWIADGTLNALTQTRHSAALTGLPSTPRADNLIMRGPDGAGASLEDMVARTERGLLLTCLWYIREVDPQRLLLTGLTRDGVYLVEGGEVVGEVNNFRFNESPVDLLSRLTEVGATGRTLPREWSDYFTRTAMPPVRVADFNMSTVSQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8K6</accession>
    <name>A0A1H6C8K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69310">
        <property type="protein sequence ID" value="SEG69310"/>
        <property type="gene ID" value="SAMN04489712_10971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="120"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG69310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="384" mass="42076" checksum="3BFA9325BCBC80A4" modified="2017-01-18" version="1">MYELDAEERAVVETVRDFVDREVRPVARDLEHSDTYPEKLIEQMKRLGVFGLAIPEPYGPGSVSTPCYALVAEELARGWMSLAGAMGGHTVVSKLILAFGTEEQKRHYLPRMATGEVRAAMALTEPGGGSDLQAMRTVAARDGDDYVIDGAKTWITNARRAQLIAVLCKTDPQARPAHTGVSILLVEKVPGLTVSKDLPKLGYKGVESCELVFTGCRVPRTALLGGVEGQGFAQMMKGLEIGRIQVAARATGVARAAFDDAFRYAQERESFGKPIWKHQSIGNYLADMATKLTAARRLLMYAAERYDSGDRCDMEAGMAKLFASETAMEITLNAVRIHGGYGYSTEFDVERYFRDAPLMIVGEGTNEIQRNVIVKQLINRGGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCM9</accession>
    <name>A0A1H6CCM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkylmercury lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70527">
        <property type="protein sequence ID" value="SEG70527"/>
        <property type="gene ID" value="SAMN04489712_109177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018836">
        <property type="term" value="F:alkylmercury lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046413">
        <property type="term" value="P:organomercury catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004927">
        <property type="entry name" value="MerB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03243">
        <property type="entry name" value="MerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="24547" checksum="3C0C433390B2A654" modified="2017-01-18" version="1">MDIEELRLGVYRGFAATGRAPDPADLAKGLRATPEEVARGLRELADRRHVVLDGAGRVVMAHPFSAVPLGFSVMGAATLWWGGCAWDSFALPHLLRGEFDEPEVVVATRCLGCGTAHAWAVGRDAPPPGDQVAHFLVPVAHMWDDVVHTCGNQRIFCGEACVGHWLERTGHERGYVMDLPTLWRFARHWYDGRLDRGYVRREPDAAAGYFREVGLEGSFWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CHM7</accession>
    <name>A0A1H6CHM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72501">
        <property type="protein sequence ID" value="SEG72501"/>
        <property type="gene ID" value="SAMN04489712_1107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="178"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG72501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="30096" checksum="6098D3165A88FB11" modified="2017-01-18" version="1">MKVVTATPSAPLASVVRRYVGYRQTGIPPGIHRGLPTRDLTFIVSLEAPVRTAAPPDPTQAPVSLQALVCGLHTRAALIARNPVEYGIAVETGPLAARALFGLPAGELAGTVVDLSTLLGRVGVELVDRLSTADTWTARFAILDEVLARQIGRTTTEVPPEVRHAWRRLTGTGTPPPMETLANEVGWSRRHLTKRFHQEVGLPPRQLRRVLRFERSLTLLRTGQWRTMTDLASAAGYHDHPHLLHEWTDLAGCIPTTWLTQEHLRVQEALDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMT7</accession>
    <name>A0A1H6CMT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid ABC transporter substrate-binding protein, PAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_110204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74240">
        <property type="protein sequence ID" value="SEG74240"/>
        <property type="gene ID" value="SAMN04489712_110204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="64"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG74240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="360" mass="39350" checksum="6C4933AF87CB8996" modified="2017-01-18" version="1">MIASDGGRFGGNWPRGRTIRTLRLGVVLAVLMLVVVTIVVLVQRGGPPTREDLLEQAHLIGKQDLRIGVKNDHPGMALYDPKTRTYSGFDIDIAYMIAGDLGFRPSQVRFLPIETEDRARMQARDADGRFVTVDMVVATFSITEERERLPTVSFSAPYLRTEQTVMTRQDVEPAESMSDFSGMRMCTTATSTSTGPAAEAKVRLVSRNSMKKCADGLLSGEFDAVTSDAAILAGFVKQYPGRLRLHDVGLDTLESYGVNTGGNDALTKLVNLSLYQSRNDPRDRRWEDAFDRNLAAEQQAAGIQQVAISEQPPVEKVEIRQWPWERDRTVGAGTFAAPAAVPVPPAAVTAAGARRGPDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQU6</accession>
    <name>A0A1H6CQU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable non-F420 flavinoid oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75324">
        <property type="protein sequence ID" value="SEG75324"/>
        <property type="gene ID" value="SAMN04489712_11118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023907">
        <property type="entry name" value="Non-F420_Flavin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03885">
        <property type="entry name" value="flavin_revert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="323" mass="35019" checksum="2E7B39D1D41403D7" modified="2017-01-18" version="1">MTVYGIHASHEQIAPGALLAAMVHAEEAGFAAAMCSDHFSPWSARQGQSGFAWSWLGAALQATGLPFGVVNAPGQRYHPAIIAQAIGTLGEMFPGRFWAALGSGEASNEHITGEPWPRKEVRNARLRECVDIIRALLAGEEVSHDGLVTVDRARLWTRPDTVPPLIGAAVSEATARWCAEWADGLVTVNAPAPTLRRIVAAYRDAGGRGPLALQVHLSWAPDEEEAVRIAHEQWRSNVFPPPVCWDLEMTDHFDAVSERVTAGQVAEVVNISSDLGRHTARLHEYAELGFDRVYLHHVGQDLGPFIDAFGAKVLPQLTGDRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRE7</accession>
    <name>A0A1H6CRE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75337">
        <property type="protein sequence ID" value="SEG75337"/>
        <property type="gene ID" value="SAMN04489712_11120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="71"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="21258" checksum="9336B2366C71B85F" modified="2017-01-18" version="1">MDLPVPDGVRSTADLARRVDRRLLLWVVGHSRPVLDRWMPRASRATDHLLGWWAVAAVMTAAGDPAVRSAARRAVAAMLLAEPVCNKAAKRVVDRSRPPRSLRGRRPGRIPDTGGFPSGHTAAAAAFTTAVIATTPRVGVPVGLLGAVVAYSRLYTGAHYPSDVAAGALAGATTALALHWSVTRGWPDRILRPHVRGAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRM8</accession>
    <name>A0A1H6CRM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75538">
        <property type="protein sequence ID" value="SEG75538"/>
        <property type="gene ID" value="SAMN04489712_11152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="17831" checksum="886460270B62F123" modified="2017-01-18" version="1">MERFETESLALLPGQRVRAKILSHQPWGVVAEIVGHERIGASVDMIQQFGSATGSYDELKAMYPPVGSQVDAVVEQVHRYNPPAWVRLSIHPEDFESFGWPCDFCGKPAVLSLGGDGLVLDVRSNDGPGSHTVISHRTCLADRIRPDNSGERARALKVGKRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CS94</accession>
    <name>A0A1H6CS94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75266">
        <property type="protein sequence ID" value="SEG75266"/>
        <property type="gene ID" value="SAMN04489712_1117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295191" evidence="2">
        <location>
            <begin position="29"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="417" mass="45253" checksum="3CF792ED74F58F47" modified="2017-01-18" version="1">MQASLPARWRRSLLGGAVAAMTAVGVCAAPVNAAPALQEVMLVGNNWEGTADVIKSTGDFAKIGRINLIPDKDQRLREIYLNPIRLAFFLGIRETVGEGHDQYVDDMYTTPDGSAIVVSRPSFADVASIDTATGALKWRFPVSGYRSDHMAVSPDGTKVAVSASTGNTVHVLNINTGQQVGSFATGDKPHENVFTNGGRYIWNMSIGEVNNDFDAPWQDFLKGDRKITIADAATFRQVKVIDMRQRLDAFGRRDMSDAVRPVAFTPDESTLYFQVSFFNGFFEYDVAADRITRMKTLPENPATDDDRTTFVNDSRHHGMSMNPAGTKLCIAGTMDDYATIVDRATLQEGPLVTAAKPYWATVSGDGRACVISESGADQVTAIDFATGRKITSVPVGDHPQRVRLAHLPAGWTGPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTA2</accession>
    <name>A0A1H6CTA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_111132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76174">
        <property type="protein sequence ID" value="SEG76174"/>
        <property type="gene ID" value="SAMN04489712_111132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027273">
        <property type="entry name" value="Neocarzinostatin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49319">
        <property type="entry name" value="SSF49319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295176" evidence="3">
        <location>
            <begin position="26"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG76174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="21163" checksum="EB00C25AD992F630" modified="2017-01-18" version="1">MKTFKPPLLLGVLGLAAWIAPSAYADGVSATGPRGQTLTISKAADVAADGEKITVTGRGFDTGKGVYVAFCRDNGPGKAPSPCGGGADTTGSTGGSHWVSSNPPPYGRNLAVPYGEGGSFEVTITVSAKLSDTVDCTEVKCVVATRADHTRSADRSQDVRVPVSFAEPGGPAGVSPVWWAGGGAVIIAAAGGILLLRRRSRAAEPEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTP4</accession>
    <name>A0A1H6CTP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">metE</name>
        <name evidence="13" type="ORF">SAMN04489712_111115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76053">
        <property type="protein sequence ID" value="SEG76053"/>
        <property type="gene ID" value="SAMN04489712_111115"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="12">
        <location>
            <begin position="3"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="11">
        <location>
            <begin position="420"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="425"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="425"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="688"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
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        <location>
            <position position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="637"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="720"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG76053.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="748" mass="81303" checksum="62DAC34FBD849C33" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYF0</accession>
    <name>A0A1H6CYF0_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SAMN04489712_11223</name>
    </gene>
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        <name type="scientific">Thermomonospora echinospora</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="10108" checksum="0B9CFB6D2689C3E7" modified="2017-01-18" version="1">MRAEVEWVDARERLPRDGMPVAAATSGRYPSNDADERDPDAGQDFWLVMPMYFTTHHIAEDGREYRDCFVDSDRIVRLPYGRSRAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZK4</accession>
    <name>A0A1H6CZK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">SAMN04489712_11298</name>
    </gene>
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        <lineage>
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                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78599">
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        <property type="gene ID" value="SAMN04489712_11298"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="97" mass="10554" checksum="0099B9FC2E38D12A" modified="2017-01-18" version="1">MGGVGPEVWIATADGRDMVRADAIVVVRLDGERLTAQLRDESKQTVTLIDGVTGANPPADFHRRLVRTVAELAESSGAQLVRAVCDEKGWRWVTEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D229</accession>
    <name>A0A1H6D229_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79317">
        <property type="protein sequence ID" value="SEG79317"/>
        <property type="gene ID" value="SAMN04489712_112198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="35903" checksum="BF70955B5BC52C9B" modified="2017-01-18" version="1">MSAPDNLVLQILAWVGGATAWPEGDADQAREAARIWNQLAEKVETNADQATSDVASVWLRNEGEGVEAFKKFWTKNFGGQIMGPSLAEPYPQQVAEHARRVAQACEAYAEAIEKHENALTIIAWVTWTNILFTISWGWVTGWAGIGAQLLLIRNRTAVAVAAQQTLFRRIMLKIVEWMLDSLGYAAGQQIVQLGTFAVGDLFMDYDDDTKRVLGFDPYSGKANLEQFGRGFLANMAFDASMDGATPLMRRVPGAAAFFDSAGKSGLPNRLLSLGGRMVGTNMYTITDNWLQGKPPEDWLPSGQQEVAKLFMHVPRLAKNPAKGPIGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2Y8</accession>
    <name>A0A1H6D2Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein, DUF2236 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79155">
        <property type="protein sequence ID" value="SEG79155"/>
        <property type="gene ID" value="SAMN04489712_112175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="50"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="314" mass="35937" checksum="8016A2F28BB3A96E" modified="2017-01-18" version="1">MSSRFPDGRLTGVRAAGAGSGSAIAWRESKWLLTLVAMSDELFRDDDIIRRVSQEGVLIAAGGVASLLQTSHPQVGQGVRDHSYTFDDPMVRLRNTMGWVYMVVFGTREEAEKLSAMVTRMHDGVTGPGYRANDPELQVWVAATLFSVAAQTYQLLFRRRFTEDELEEFYQQSKIYATILGCPEDAMPAGYREFREYYAHMVNTLQINDASRYIADGVLHPTNLPLIMRPALVPIRLITSGLMPPPIREQYGWKWNAFREFQFHLLMRGLSLVYPRLPERVRTLPREIYLRQTRKILRRQINGRPRLKVRSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3U4</accession>
    <name>A0A1H6D3U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79463">
        <property type="protein sequence ID" value="SEG79463"/>
        <property type="gene ID" value="SAMN04489712_112219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="129" mass="14501" checksum="9E4315C49C2048E6" modified="2017-01-18" version="1">MQAIDPTAHSPGACQAREVLDRVGDKWSLYVISQLGSGTKRFNELKREIDGISQRMLTVTLRGLERDGIVTRTMYPVMPPRVEYSLTDLGRTLLETVGTFVRWAEENLDQIEAARARYDARAGEIEAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D452</accession>
    <name>A0A1H6D452_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79575">
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        <property type="gene ID" value="SAMN04489712_112239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG79575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="788" mass="81220" checksum="88CA6234441250A2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D482</accession>
    <name>A0A1H6D482_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, DHA2 family, multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80147">
        <property type="protein sequence ID" value="SEG80147"/>
        <property type="gene ID" value="SAMN04489712_11325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG80147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="522" mass="52977" checksum="A5D355CA0D6B63F3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D561</accession>
    <name>A0A1H6D561_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80391">
        <property type="protein sequence ID" value="SEG80391"/>
        <property type="gene ID" value="SAMN04489712_11373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="74" mass="7847" checksum="B944C5D497E60537" modified="2017-01-18" version="1">MAAGAAVPGVVLKGGDAQVLCLTCRRVRPALSPAEYTVARARLITRHGLCMCLHTGRRPPSRPETPETTPAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D582</accession>
    <name>A0A1H6D582_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80527">
        <property type="protein sequence ID" value="SEG80527"/>
        <property type="gene ID" value="SAMN04489712_11398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="161" mass="17310" checksum="7B9B41E66E6A881E" modified="2017-01-18" version="1">MFACVQPSSSVDRLADGLGTLLGYLMRTAEGDIFRDLMELDLSPSQVRALFLLDRAASPPAVHELAAELGLSMAAAGRAADALVRHGLAERHSDAVDRRVKRISATAAGRDLVGRLCAARRDDLRRFAESLTEEERTGLVNALAPILARPQVRALTIGPHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6N5</accession>
    <name>A0A1H6D6N5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80385">
        <property type="protein sequence ID" value="SEG80385"/>
        <property type="gene ID" value="SAMN04489712_11372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="246"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG80385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="421" mass="45324" checksum="5B461CA0BC39CE56" modified="2017-01-18" version="1">MPDRPPDRPVVPRPHACRDPRPAAHGPVDPPEAAAGAADGAAPRAVICDSWRRSRAAGGDVEIPAAPLVFDADARAAHPLDRHLERVLRRWSCVGAPVTDPDTGHVLDCIDLSATVDALHPAAVGLVAAAARLAESRLELRMQARDELLRERYLRHLRGLGGGAAALVTGTGRVLAADPEGWRGLRVPAPRDGAHLTLPDGRLAVAETLGEVFLLRAAEPGRREDGRPLLTLSLLGADPPHALLDGAALPLTLRHAEILALLALHPRGLSADQLSAQLYGDEGNPGTIRAEIHRLRDRLGELLPAKPYRLECELDADFLTVRRLLADGGADELTQAARLYQGELLPRSESPELRAERDELAVRLRSQLLDRGGPDALWEYAQTSAGQDDLEILQRLVAILPPGEPRRAAAQSRAHRVLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7U8</accession>
    <name>A0A1H6D7U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81369">
        <property type="protein sequence ID" value="SEG81369"/>
        <property type="gene ID" value="SAMN04489712_11439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="463" mass="49884" checksum="592BA2AAE1B0C385" modified="2017-01-18" version="1">MDHQPTSVYSPLTLAATEPLLTRDFDARPALVYERLRAKYGAVAPVDVHGVPAWMVLGYAEALEVLRNERGVWSKSIDNWRAYAEGRVPADWALLPFHASGGVPYTSGRVHAHLRGAWTTALRPFQDRTQPQARRMESEVRRYADELISLMAAGGRSGWADLSAQYSRPLIVMVFNLLVGFGAATDDVLMDMWRLMDGTPDSAEAMVRLTEMIGQAVTAKDRQPGDDLPSYMMAAGLTVEQATTETIMLMGALGDMTSSLICNAIVEVILDTAGARASLAAGMIRETVNRAAMASPPNPNLTFRYATADTMIGDTAIAAGDPVMLSLAAAHADHRFADPLDLSSVHSSRAHLSWGAGAHQCPADDLATTLVSIAVERLFERMAALELALPPDQLPWRSSLVMRGLRSLPVRFQVVESFTPSARAGSLGATGEPGGAEAGQSLQGGSRSALTRLMRSLLRQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBX7</accession>
    <name>A0A1H6DBX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsF</name>
        <name evidence="6" type="ORF">SAMN04489712_115116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82967">
        <property type="protein sequence ID" value="SEG82967"/>
        <property type="gene ID" value="SAMN04489712_115116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG82967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="10920" checksum="11534C8FC76B72F6" modified="2017-01-18" version="1">MRRYEVMVILDPSIEERAIAPSLDQFLTVVKNGGGSVEKVDIWGRRRLSYEIQKKGEGVYAVVDLTAEPAIVKELDRQLNLSETVLRTKVIRPEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DD58</accession>
    <name>A0A1H6DD58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_115169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83201">
        <property type="protein sequence ID" value="SEG83201"/>
        <property type="gene ID" value="SAMN04489712_115169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="247" mass="27993" checksum="800954776D4C5B60" modified="2017-01-18" version="1">MPELEQSLPKYLQIAGHIRDRILRGDLQPGDEVPSERQIASEWNVSRPTATKALEALRVQGLVESRRGSGTYVLNRYDLNRRARERYQKADQTGRIYPPNERAEIVAAEIVEAPAHVVEALALGSGQRAVRRHRITYRDDQPVETSTSWYPADIADRAPRLVERGRIREGTLAYVESTTGRRARHAYDRVAARLAGEEELAVFGLTGPAAVLVVRHVVFDLDERPLEFAEAVYPPDAWTYEQQYTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNZ6</accession>
    <name>A0A1H6DNZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermidine/putrescine transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86911">
        <property type="protein sequence ID" value="SEG86911"/>
        <property type="gene ID" value="SAMN04489712_12032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="416" mass="45995" checksum="2EEBC81355FB5B02" modified="2017-01-18" version="1">MSRHPHPGDPAFLRGLIQPRMRGPLTGRRDVLRLFGAAGAGLALAACGVQGQGGKDKVSQSDVQKFWAGKAKNGTLNWANWPGYMEEDRATIKAFTQATGIKVDYKEVIQENAEWFGKIEAPLRAGQSIDFDLMVMSNGIQLEKARQLGYLAPLDHSKLPNFAKNAGPSYKNPSYDPGNAFTIPYTSGVTGIAYNTKYVKEEITSISALWDSQYKGKIGMMADSQELGNFGMFAVGVDPEKSTPADWQKAADKLREQRSLVRKYYTQDYADAISKGDVWITMAWSGDVYSLGLDDVKFVVPQEGGTIWTDNMCIPKTAANPVDALTLMDWLYDPRANATLTEYINYITPVPAAQEIIKQDAAQAKGAEKAELERLAASSLVFPTQQDMARLRRYRTLTQDEESEYQKVFNPISQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP38</accession>
    <name>A0A1H6DP38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, MSMEG_2516 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86523">
        <property type="protein sequence ID" value="SEG86523"/>
        <property type="gene ID" value="SAMN04489712_119102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019923">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03621">
        <property type="entry name" value="F420_MSMEG_2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="310" mass="32947" checksum="3D54026D787CC4FA" modified="2017-01-18" version="1">MVEIRPFRFGVEAAGARTAAGWRDMARAVEDLGYRTLLVIDHLGDQLAPIPAMLAAADATTTLRVGSHVLANEFRHPALLAKEAATVDLLTGGRLEVGIGAGWNHDEHARLGIGLPDPPTRVARLAEAIAVIKGLLGNEWFDFSGDHYSCERMPGLPRPVQQPRPPLMVGGGGRAVLSLAAREADIVSLNPNLASGRSDASAAGTMTASATATKVDWIRAAAGARFEALELSVRVYYTVVAGDAWGTAADLAPLTGLLPKEALRSPHLLLGDTSRLVDAIQEHRERYGISYFVVTSDAYEAFAQVVSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP70</accession>
    <name>A0A1H6DP70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87014">
        <property type="protein sequence ID" value="SEG87014"/>
        <property type="gene ID" value="SAMN04489712_12052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019592">
        <property type="entry name" value="DUF2469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10611">
        <property type="entry name" value="DUF2469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="12360" checksum="897415A094CA7DEE" modified="2017-01-18" version="1">MSAEDLEKYETEMELQLYREYRDVVGLFSYVVETERRFYLTNSVDLQVRSAENGEIFFEVTMQDAWVWDMYRPARFVKNVRVVTFKDVNVEELAKSDLEPPSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPL5</accession>
    <name>A0A1H6DPL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86586">
        <property type="protein sequence ID" value="SEG86586"/>
        <property type="gene ID" value="SAMN04489712_119119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296087" evidence="1">
        <location>
            <begin position="42"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="14275" checksum="D8E0B4D24FECDBCC" modified="2017-01-18" version="1">MTTKTKAAGQGSGKLRRAIAAGGAVLGAMTLPAVSPPAAFADPNQTCGDRQGVCIKIAREGTSVDFAQAYHDGRTGDWEGKIDLTREGFTTIQGPVGRPPGPATQNHRLVYQPGARICARGFELPGWRAKGVACLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQM8</accession>
    <name>A0A1H6DQM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxo-5alpha-steroid 4-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_120154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87551">
        <property type="protein sequence ID" value="SEG87551"/>
        <property type="gene ID" value="SAMN04489712_120154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="23"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG87551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="495" mass="52002" checksum="C679F7A8B6D0939E" modified="2017-01-18" version="1">MTPVHPVEPVSARDLGGYDHECDVLVAGFGCAGAAAAFEAATAGASVLVLEKAGGPGGTSAVSGGELYLGGGTRIQQACGFDDTPDEMYAYLEAALGPHADTAKLRLYCDQSVEHFEWLRARGVAFKPSLYDAPTWMPYTEDGLMWLGENAWPYNTLAKPVPRGHRPVAKGFGGQVLMEKLTAAAIEAGVVTHADTAAANLVLDDEGRVAGVVARRYGERVTYRARKAVILTTGGFVDNEEMLAHHAPVLIGHGKVSDGNSDGSGIRMATAIGAATRRMGVVEVALTALPAMLVRGMLVDGLGRRFINEDVYPGMFSHHAVLHQPGPYWAVVDEEGFESVPEDERWGVRPAFAAESLAELEAELGMPPGSLENTVEVYNRHAEKGEDPYFHKDPRWLRPLRPPFAAIDPREGFFGLGREGSGTGTGVNGFTLGGLHTTVDGAVLNHSGAPIPGLYAAGRAAAGIHGEGYVSGTSLGDGTFFGRRAGRAAAGAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSV5</accession>
    <name>A0A1H6DSV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reductase C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88124">
        <property type="protein sequence ID" value="SEG88124"/>
        <property type="gene ID" value="SAMN04489712_12181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="321"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="41887" checksum="3A2EDC662E5A9777" modified="2017-01-18" version="1">MRSMQNVVVVGGGAAGVAAVESLRREGYGDSLVLLGEEPALPYDRPPLSKQVLTGAWDDERTRLREEGHYADLDVRLLHGRACALDAERRLVRLDDGSDLAFDGLVIATGVQPRRLPEGHRLAGVHVLRSHPDLVELRTAFRACRRVVIVGAGFLGMEVAASARGMGLDVTVVDPLPQPMIRQVGPEVAAAVAGLHRDRGVDVRTGAGVGGLQGEDGQVTAVALSDGTVLPADCVLVAIGAVPAVEWLSGSGLPLGDGVECDEYCRAAPGIYAAGDVASWINPRYGRRMRLEHRMNATEQGAAAAHNLLHGDVKPFSPLPYFWTDQYEVKIQAHGILPEGSEVTVEEGSVDGGKFVAVYRTDGEITGVLGWNAPTLILPYRKRLLEQQAAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSV9</accession>
    <name>A0A1H6DSV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87806">
        <property type="protein sequence ID" value="SEG87806"/>
        <property type="gene ID" value="SAMN04489712_1215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="28646" checksum="EA52662376A3A6F4" modified="2017-01-18" version="1">MGHLALAAATSHVGAIVKHAQADPEVSGVLHDAWRRLDAEIAAARLDAVVVAATDHYETFGLENYPAFCLGLAEEHHGWAEFGNPGGTVPGRPEVAEALLEGLTARGFDLARSHTMALDHSFMVPLTKLPSAAAAGIVPLFVNCNTPPLPTLGRCLALGAALRDTVRALPGDARIGVIGTGGLSHWVGLPRFGEINEEFDTRFLALLREGRAEEVLTWDDAHILNEAGNGALEIRTWLIAAGAAGGPARVHAYRPMPAWTVGIGVSGFEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTJ5</accession>
    <name>A0A1H6DTJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88702">
        <property type="protein sequence ID" value="SEG88702"/>
        <property type="gene ID" value="SAMN04489712_12262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="10566" checksum="8DC4FCD6454CF69A" modified="2017-01-18" version="1">MRIEGTSALVTDVTSTERSQTAIAAAQEAGPLRAVVHCTGIGNPIRMVGRDGTPGGLPGFEQAIGVNLIGSCNALRLGAAAMAANEPVDGETVRLDGTIRVAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUL9</accession>
    <name>A0A1H6DUL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin HHE cation binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89047">
        <property type="protein sequence ID" value="SEG89047"/>
        <property type="gene ID" value="SAMN04489712_1239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="183" mass="20693" checksum="0478AB1DC0687E30" modified="2017-01-18" version="1">MTQTKTEMDVIDLLVHQHSMIRDLFAEVLEHSGEQRRESFRRLVQLLAVHETAEEEIVHPVSRRSLPGGEGIVDDRLAEEREAKELLSELDGMDIHDPQFLPKLDKLRVSVLTHARAEERYEFYRLKDEFSDTQRRAMAAAVRAAEATAPTHPHPGVESATANLAVGPVASVIDRVRDIIRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVL1</accession>
    <name>A0A1H6DVL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88625">
        <property type="protein sequence ID" value="SEG88625"/>
        <property type="gene ID" value="SAMN04489712_12246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG88625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="314" mass="33237" checksum="6CB9BB8E18F3BB6A" modified="2017-01-18" version="1">MLRMVVLRLLAMIPLVFLVATGVFFLGQLSDVDPAENIVGPNATEEQVAAVRAELGLDRPALEQYADWLSGAVRGDLGESLYTKADVTTSLTQALPITLSLTFGGLLVGLALGVPSGIWSALRAGRAGDRAVSLLATVGQAVPGFWLGLLLIIAFAIRLPWFPAVGYVPPGESLTGWLHCLVLPSVSLGLIAAAAISRQTRSSMIGVLQQEYVRTALSKGLSKRRVVVKHALKNAAVPVVTVVSFQVTTLLGGSIVIERLFAMPGLGALAINAVVRRDPDVIQGIVVLTVIVIVLVNVLLDLSYAWLNPKVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXV8</accession>
    <name>A0A1H6DXV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90172">
        <property type="protein sequence ID" value="SEG90172"/>
        <property type="gene ID" value="SAMN04489712_12559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="17346" checksum="33530E4D345BD6B7" modified="2017-01-18" version="1">MSTTADAVTFSDLSRNPKSVAERAARLGRLRVTHRDAPDFYLTAADREEQRDESLTTASRIFLALMKHDPSARALLLAMPDVFPWARHLSTEEVRAFTVELVDALSDAAELDLDTNAQEVITNWRATARIKADRTEYEEALRPTSGDFDPVEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY21</accession>
    <name>A0A1H6DY21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12576</name>
        <name evidence="3" type="ORF">SAMN04489712_13161</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="de Groot N.N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90232">
        <property type="protein sequence ID" value="SEG90232"/>
        <property type="gene ID" value="SAMN04489712_12576"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91991">
        <property type="protein sequence ID" value="SEG91991"/>
        <property type="gene ID" value="SAMN04489712_13161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="89" mass="9926" checksum="FCBA38EBCACE19B9" modified="2017-01-18" version="1" fragment="single">MALKHYPEEFKADAVALYLSDPSKTYRQVAEDLGINRATLRQWVIDARRRGEAGPKPKPAGKGNPAQDVASPDVLEKENQQLRARIAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E131</accession>
    <name>A0A1H6E131_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91262">
        <property type="protein sequence ID" value="SEG91262"/>
        <property type="gene ID" value="SAMN04489712_12875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG91262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="25252" checksum="087106AEFD2F491D" modified="2017-01-18" version="1">MVKGEAGGVWFRPERSGRSERNAPPLSRERIVTEAIALLDEEGITRLTMRRLAERLNAGATTLYWHVKTKDDVLDLALDTVFGEARVPDEPSGDWRADATALMGEWRAAMLRHPWTAVLLGRPLMGPNVLERTEFLHATLVEAGLSGPRLTAATYALSHYVIGSAMMQAAWRGHEDPATRQTIADHLTAHRDRYPSLVDHGHPSTDWDAVFAEGLACLLDGIAARMPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E203</accession>
    <name>A0A1H6E203_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Golgi phosphoprotein 3 (GPP34)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91411">
        <property type="protein sequence ID" value="SEG91411"/>
        <property type="gene ID" value="SAMN04489712_1299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="PTHR12704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="247" mass="26409" checksum="45C416FAB67DA0B9" modified="2017-01-18" version="1">MFVLGEWGIMLLMELTLAEELLLIVLKDDTGKPMIDGQRLSAALAGAALVELTLEGALRVTEDGDPDHRAGRLVATGAQPGDPRLAELVKEAHDTKPKNAVSRLSGVSAWRNRAKDLKEALLEDLTEQGVLTRERHKVLGLFPTTAWKPGDASVERRIVDRLRSVVVDGREPDERTAALVSILYAVDVLPKLFPDAPRKAVKERGKQISESDWGGKAVRQAVQAAQAALIATITAATAASTAGSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3E1</accession>
    <name>A0A1H6E3E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91395">
        <property type="protein sequence ID" value="SEG91395"/>
        <property type="gene ID" value="SAMN04489712_1294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="45" mass="4616" checksum="5B1C5B15327EBBC2" modified="2017-01-18" version="1">MADGTRKPIDELQVGDKVLATDPDTGRTGPQTVVSTISSAGSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E503</accession>
    <name>A0A1H6E503_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92313">
        <property type="protein sequence ID" value="SEG92313"/>
        <property type="gene ID" value="SAMN04489712_13313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="149"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="329"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="747" mass="81584" checksum="D7EEBEFC91DE12C5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5C0</accession>
    <name>A0A1H6E5C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92827">
        <property type="protein sequence ID" value="SEG92827"/>
        <property type="gene ID" value="SAMN04489712_13542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="11166" checksum="568B414F1ED787D4" modified="2017-01-18" version="1">MPSPHPPEFRRRAVELARQGDKPLVQLAKDLGISRSCLQNRVSQADADDGQSGESGRLTSTEKKELAELRRRNRQLETENEIFKRAAAYFARENVFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5G9</accession>
    <name>A0A1H6E5G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulatory protein, FmdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92135">
        <property type="protein sequence ID" value="SEG92135"/>
        <property type="gene ID" value="SAMN04489712_13235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="113" mass="11334" checksum="3B6915EE645AC23E" modified="2017-01-18" version="1">MPTYQYVCTECGEPLEVVQKFSDDALTECPACSGRLRKVFSAAGIIFKGSGFYRTDSRGGGKSSVGSTTSSNGSSDKSADTKSESATKSDSSSGGSTAAASSSSGSGSDSKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5I8</accession>
    <name>A0A1H6E5I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92952">
        <property type="protein sequence ID" value="SEG92952"/>
        <property type="gene ID" value="SAMN04489712_13626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="16642" checksum="AD10A51D2A286F64" modified="2017-01-18" version="1">MSIPRIYHVGIVVAALEPAMEEFSEATGVTWGRVQRFPAEFATPSGPRTFHQTFVLSLEGPPYIELLVRVDDSVWEKTGLHHLGMWSEDVAGESAALEGRGCAWEAAILDGEGRRAGGCYHTLPNSDARIELVSRAASAPRLERYLAGGDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5Q9</accession>
    <name>A0A1H6E5Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_1338</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92296">
        <property type="protein sequence ID" value="SEG92296"/>
        <property type="gene ID" value="SAMN04489712_1338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="77"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="186"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="296"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG92296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="656" mass="71114" checksum="C661CF63483346F8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E659</accession>
    <name>A0A1H6E659_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein N-acetyltransferase, RimJ/RimL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93127">
        <property type="protein sequence ID" value="SEG93127"/>
        <property type="gene ID" value="SAMN04489712_13720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="172" mass="18616" checksum="13E1B285A2F3DB4F" modified="2017-01-18" version="1">MSSYPQVRLLAATESLLNALNDNRALFGELIGSSVPDGWPEFPEAIGFTLEHLQTASEADRSWSMQFFLDPATGQLLGSGGFAAPPAERTVEIGYEIAPEFRGRGFGVAAARALVERAVASSEVDHVLAHTLPGPNPSTGVLVSLGFEHTNDQEDPEVGVVWEWRWTRPLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6I4</accession>
    <name>A0A1H6E6I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-xylose transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92495">
        <property type="protein sequence ID" value="SEG92495"/>
        <property type="gene ID" value="SAMN04489712_13415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="28646" checksum="B3891C1F63461501" modified="2017-01-18" version="1">MSVTPVLDLRGVGKSFGPVQVLHDVALSAYAGEVTALVGDNGAGKSTLVKCLGGILPMDSGDYLFEGRRVRVNSPREAAELGIEIVHQDLALCENLDIVQNMFLGREWRSGLVLDEPAMEELAARTLTGLSVRTIKSVRQPVSSLSGGQRQSVAIARAMLWDSKVVVLDEPTAALGLAQTQQVLEVVRRLADKGRAVVLISHNMNDVFAVADRICAMFLGSTVAQVRASDVTHAQVVELITSGRGADGPSGVPARMNGVGRARRGDEAGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E759</accession>
    <name>A0A1H6E759_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92999">
        <property type="protein sequence ID" value="SEG92999"/>
        <property type="gene ID" value="SAMN04489712_13641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="73" mass="8114" checksum="583F5B3EFFF71C4F" modified="2017-01-18" version="1" fragment="single">ATMELAGQIARMHPFALRQAKRAVNQTLDVQGFYAAVQSVFDTHQTGHGNALSVDGYPVLMQLEGMKDKLRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8G0</accession>
    <name>A0A1H6E8G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG94012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94012">
        <property type="protein sequence ID" value="SEG94012"/>
        <property type="gene ID" value="SAMN04489712_14226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="15745" checksum="D0DA74E2541171FB" modified="2017-01-18" version="1">MTEERGHGRINRWTTWTTGTDEGIGPPCAARLAVIRRDVADLAGQPLSKQIVLAATSRARLSAAEVSAHLRRHWGIENLEHRPRDTIWREDDQQAYLGNGPRAMATLRNLALGLLDINGIIKIKETVQAIGRNPMRAVPLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8H4</accession>
    <name>A0A1H6E8H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE superfamily endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93571">
        <property type="protein sequence ID" value="SEG93571"/>
        <property type="gene ID" value="SAMN04489712_13933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="97" mass="10228" checksum="0C39C069F31F921A" modified="2017-01-18" version="1">MYGRVATAAGSPSPCTPARRLPGGTNDSAFATKRRIAAGQAIAAAEAGVVFRTAVADCAYGDLDDLRAELRRAGLGWVVAVRPRRSTWAYRDQAHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9L9</accession>
    <name>A0A1H6E9L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94518">
        <property type="protein sequence ID" value="SEG94518"/>
        <property type="gene ID" value="SAMN04489712_14812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="17155" checksum="DD7E52145BCE073B" modified="2017-01-18" version="1">MEAYSEGHISYEELDEHLHQALTATTHDELVQALASLPEENAGSTSTIAAASGLIRRRGAWRVPRVLTVESALGRVHLDLSRAIIEHPVVDIELRLGTGRAKITVPRDAIVDIEGLRTGWTDPRYTTRRRSDSGGPTIRISGAMGLGRLKIHHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAM4</accession>
    <name>A0A1H6EAM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000051">
        <property type="protein sequence ID" value="SEG94772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94772">
        <property type="protein sequence ID" value="SEG94772"/>
        <property type="gene ID" value="SAMN04489712_1513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG94772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="91" mass="9899" checksum="1FCC79AE11E93283" modified="2017-01-18" version="1">MAARGSIDLHSSDELRERLEALVEAGHREIVVDLTAVDFCDSSGLNVLVRAYKHARTQGGAFTVTGAYGRVENVLRTTGLDRFLISTPPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBA0</accession>
    <name>A0A1H6EBA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobQ/CobB/MinD/ParA nucleotide binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000062">
        <property type="protein sequence ID" value="SEG95050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95050">
        <property type="protein sequence ID" value="SEG95050"/>
        <property type="gene ID" value="SAMN04489712_1623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG95050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="216" mass="23521" checksum="1B31B413FAB80587" modified="2017-01-18" version="1" fragment="single">ENLDVLPGGDELHDMVAMLESRRRRNGAEAVLALARALASTGKDYDFILLDCPPGEPQIQEIALAAARWVAIPFRSDASSRRGLGKVATLMSAAWELNPELELLGVYLYGAGKGATQIRKKSLEEIRKVLGPDAPVLDTVISHLEAPAFDIRERGQLAHELERDVASGPAWYEQLRSGVPIQRGPASTSQNLANDFRDLAQELFGLLSAREQAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EE01</accession>
    <name>A0A1H6EE01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000066">
        <property type="protein sequence ID" value="SEG95104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95104">
        <property type="protein sequence ID" value="SEG95104"/>
        <property type="gene ID" value="SAMN04489712_1662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045683">
        <property type="entry name" value="DUF6192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19691">
        <property type="entry name" value="DUF6192"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG95104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="30684" checksum="184FF7C25D8DFFD3" modified="2017-01-18" version="1" fragment="single">MADKIGNVTERRFDTLVDRAHDMVQTMTSHQFAIGDMALEIEPIRRPRSGRDEGIHASLRLFADEIGETFDTVLTWRWVADAWPADQRRADVSYSVHRVMASHPDRFKLIRKPPLDRRGRRHWTTEAAAKAVAKAEGRAEGHVRTVSADTKVRRIRELASDDTVRSAVAAEFLSRPDVAGRVMADPHTRRQLYRAQRDHDQQVQDTARERTPAIKHVERSIHFLDLLRTGHAFVSGIKRLMPRIQADPLTRQDRDVIHHLLDQAQAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S1S0</accession>
    <name>A0A1H5S1S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44535">
        <property type="protein sequence ID" value="SEF44535"/>
        <property type="gene ID" value="SAMN04489712_10145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009283609" evidence="2">
        <location>
            <begin position="25"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF44535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="506" mass="54847" checksum="AED79D6C91CC9C21" modified="2017-01-18" version="1">MRIHRGIALAVLSALLIPFSTAGCSASRDAGPAPSRSAGAAPSPTVTEENSRPGTRDWKLRRKGAQEEIEGFADRVSVLPGEAFRLLVSTTTAGFRVEAFRVGWYGGDQARKVWQSSRQPGVRQPAARTEAKTGTVVAPWKPSLTVPTQGWPEGVYLLRLTADSGAQRYVPLTVRSADTAGRIVVLNATTTWQAYNTWGGRNLYTGPGGYPDRARAVSFDRPYDKDGTGKFMGYEHTAIVQAEKAGVPLAYATDNDLHRRADLLRGARGLLTLGHDEYWSTAMRDNAVRARDQGVNIAFLGANAVNRHIRFADTPLGQDRLVICYKDAAEDPVARTNPAESTQDWRLPPRPRPESDLIGIMYNCFPATGSFTVYRPGHWLFRGTGVRKGTRFPGLIGPETDAINWAGPTPRPIEVLAHSPINCGAFVKTADATYYTTRSGAGVFATGTMRWVCTMRGPSCGHGVTAAGQRFVLKVTENLLHAMAAGPMGRAHPADDNLEEFGQLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S888</accession>
    <name>A0A1H5S888_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46813">
        <property type="protein sequence ID" value="SEF46813"/>
        <property type="gene ID" value="SAMN04489712_101113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF46813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="32734" checksum="DBF02FB053316AC2" modified="2017-01-18" version="1">MALTIGVDVGGTKVAAGVVDDGGRILEQVRRPTPSTDPRQTAEVIAEVVDLLKGKYEQVEAVGLGAAGFVDEARATVLFAPNLAWRDEPIKDKVEELVGMPVVVENDANATAWGEFRFGAGRGERFLVLVALGTGIGGGIVVDGELYRGRFGLAGEIGHLRMVPDGRRCGCGNRGCWEQYASGNALVHEARELARVAPLMAARLLELGDGTPEGVGGLEITQAAREGDRAALECFGTVAAWAGQGLADLAAILDPGAFIIGGGLSDAGDLLLEPVRAAFEAAVTGRGYRRLPEVRIAELGSAAGIVGAADLARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SBU0</accession>
    <name>A0A1H5SBU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48076">
        <property type="protein sequence ID" value="SEF48076"/>
        <property type="gene ID" value="SAMN04489712_101149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03034">
        <property type="entry name" value="ArsC_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006659">
        <property type="entry name" value="Arsenate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF48076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="12686" checksum="EAD0F8994112DF78" modified="2017-01-18" version="1">MEIWHNPRCSKSRAAKAALDEAGVTYTERRYLDEPPTAAELDAVLTAIGAEPWDVARLNEPVAKELGLKDMARDRARWIEVMVAHPVLIQRPIIATGGRAVVARDEGSVRAALDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SFY7</accession>
    <name>A0A1H5SFY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">16S rRNA (Cytosine967-C5)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48888">
        <property type="protein sequence ID" value="SEF48888"/>
        <property type="gene ID" value="SAMN04489712_101173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="8">
        <location>
            <begin position="185"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="286"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF48888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="472" mass="50023" checksum="51B4F139C27D44BC" modified="2017-01-18" version="1">MTPRTSRDRRDRNRRPGGPRRTGGPEDLVRRTAFDVVRAVQTRDAYANLLLPGRLRERGLTGRDAALATELTYGTLRGRGTYDAVLAVCSDRPLHRIDGPLLDVLRLGAHQLLATRIPPHAAVGTAVELARSVAGPGQAKFANAVLRKVATRDLAAWLDIVAPPGDEVGRLSVTYSHPRWVVSALRDALGPGRDEIEELLAADNARPRVTLVAKPGRATVEELLAAGAEPAPYSPYAAILPEGDPSAVAAVAGGRAAVQDEASQLVALALADAPLDGSDARWLDMCAGPGGKAGLLSGLAAQRGTRLLACDVQPHRAGLVRRAVDGRTGVAVVDGTVPAWRPGSFDRVLLDAPCTGLGALRRRPESRWRREPGSVAELGPLQRALLTSALEAVRPGGVVAYVTCSPHLAETRVVVDDVLRGRQDVQRLDSPAVLAGSAAREPAGLGEGPYAQFWPHRHGTDAMFLALLRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SIN7</accession>
    <name>A0A1H5SIN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system, NarL family, sensor histidine kinase DesK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50489">
        <property type="protein sequence ID" value="SEF50489"/>
        <property type="gene ID" value="SAMN04489712_101229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="204"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF50489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="42474" checksum="82838E6C8B7193D9" modified="2017-01-18" version="1">MIGTGTSADIAERAARRFDKARRLTEGTFLVAGGGIGMGLGLSLSDLYADGEIGLPLALLLVAGLMAFTVMYMRLVRAGMQGRAPVGELVLSAVLAAALSAVVGKHPLWVLLGPFWASVAALCLPGLRRIAAICAGTGAVLASYTVVAAGDRAHWYMWPTMFVLLSLVSGVMVAANMAQKWLWDVMQEAHAAREAQARLAVTEERLRFARDLHDLLGHNLSLIAVKSELAIRMTPTDPDRARAEMADVRQAARDALREVRAAVRGYRVVELDAELASIRAVLEAAGVRCTVPQDPGGLPPEIGGVLAWVVREGATNVLKHSDARRCDITLARYDGSVVLEMVNDGARPAAAGHGTGLTGLTERLAAVGGGLTAEHTGHGRFLLRAAVPLPEPVSGGEPLRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SXM0</accession>
    <name>A0A1H5SXM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Condensin subunit ScpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54688">
        <property type="protein sequence ID" value="SEF54688"/>
        <property type="gene ID" value="SAMN04489712_101385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF54688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="311" mass="34364" checksum="9D8238A2E18773D4" modified="2017-01-18" version="1">MPGQWSGSVTVCNVKHTAAPQTGATQVAAAQAEERPGGFQVHLDNFEGPFDLLLGLISKHKLDITEVSLHKVTDEFIAYIRSRGAEWELDQASHFLLVAATLLDLKAARLLPSGEVDDEEDLALLEARDLLFARLLQYRAYKEVAKVLAGRMAEQSRRFPRTVPMEPRFANLLPEVLLGLGPAEFARLAAKALAPKGPPPGVSVEHMYQPKASVREQAAIVVAKLRRLRQATFRALTADCQGTFEIVARFLALLELYRERAVTFEQVEPLGELHVSWTGSDDGDVAVGDDYEGSRDAEGRRRDEDGHDRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T3H1</accession>
    <name>A0A1H5T3H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57452">
        <property type="protein sequence ID" value="SEF57452"/>
        <property type="gene ID" value="SAMN04489712_101472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="467"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF57452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="559" mass="59351" checksum="D2F52712AE2DFF37" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TFQ6</accession>
    <name>A0A1H5TFQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61655">
        <property type="protein sequence ID" value="SEF61655"/>
        <property type="gene ID" value="SAMN04489712_101602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF61655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="30220" checksum="48ECB29CC5C4B1F7" modified="2017-01-18" version="1">MTTSLGDVRPVGEQLRAWRQRRRLSQLELALEADVSTRHLSFVETGRSAPSREMVLRLAEHLDVPLRDRNLLLVSAGYAPVYAETSMDEPRMDSVRAALRQVLTGHEPYPAVVVDRFWNLIDANAAAALFTERATPELLEPPVNVLRLSMHPAGMARDIINLGEWRAHMVDRVRRHVALTADESLARLYQELRDYPVTEAETESPFEMPTGNEVFVPLRIRSGDRVLSFFSTIATFGSPVDITVAELAIESFYPADRPTADFLRERAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TLR0</accession>
    <name>A0A1H5TLR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-lactate dehydrogenase complex protein LldE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63699">
        <property type="protein sequence ID" value="SEF63699"/>
        <property type="gene ID" value="SAMN04489712_101670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="132"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF63699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="25881" checksum="2DEBFB771DEBC1B0" modified="2017-01-18" version="1">MRVALFVACFNDVLFPRTGEAVASLLTRLGCEVSFTPEQTCCGQMHWSTGYQREAAGLARGFTEVFGPQDVVVTPAASCATTIRDAYPRIAEATADPGLAGAAARLTVYELTEFLVDVLGVTDVGAYFPHRVAYHPTCHSLRALRLGDRPLRLLRAVRGLELAELPAAEECCGFGGAFAMKNSDVSVAMVADKVRHIRQSSADVVCAVDNSCLAHIGGALSRLRGGVRAMHLAEILAATEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TSI8</accession>
    <name>A0A1H5TSI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Demethylmacrocin O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65188">
        <property type="protein sequence ID" value="SEF65188"/>
        <property type="gene ID" value="SAMN04489712_101714"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00894"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040800">
        <property type="entry name" value="MycE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17843">
        <property type="entry name" value="MycE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MycE_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF65188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="43237" checksum="659509E63619B9A6" modified="2017-01-18" version="1">MPKTSTTLTERLILAGTASDREIAELVDDAGLDAVVAALVEEILSRCEQPVNIKAVHIALDVDHGDERRRVVLRVHRDEPVRVVDEPAPVVWSRLGITVTDLIRRLYGRTDHRRTGDFHNSFVPDAPSPQDMYFELPEIFNSATQATGTVIAGCAAHSADLGSLSVRSGSDKWASFHWYTPHYERHFARFRDEPVRVLEIGIGGYDEQLGGGSLRMWKRYFHRGLIFGLDIFDKTELTEPRLTALVGDQNDPECLVALAERHGPFDIVIDDGSHMNEHVHTSFAALFPYVRDGGIYVIEDMQTSYLPSFGGSPGDSAGPGTSVGLVKGLLDDLHHRERPRRNGAEPSITQRSVTGVHVYHNIAFVEKGTNGEDGLPGWMDVAAWDALGATDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U318</accession>
    <name>A0A1H5U318_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69512">
        <property type="protein sequence ID" value="SEF69512"/>
        <property type="gene ID" value="SAMN04489712_101855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="168"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF69512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="38989" checksum="88E4B79D41A65156" modified="2017-01-18" version="1">MIWTAGFRTAVISPYEQIQLSEPRGFADQTVRQVLHMAGGGELLRVRLTNRYGRTPLTIAAARAATEHGQAVLTFDGAEGVTIPPGEEAVGDPVDLPVAPGADLLLSLYFPEETGLATYSHMPMETAHIVGGNHVASPALPDAEQVEARFYVSGVDVLTPDDTAIAVAFGDSWFEGVGSTTGANNRSVDFLNRRLKRGWVVNQGIAGNRLLRDEVGEHALARFDRDVLSIPGLTHVLVHFGINDLGLPGMSGEPPATSGALIEGFKALARRAHKADLKILAATIGPFAGAVYPGISTPEGLAARREVNDWMRTTDTFDAVFDVARAVENPEASDYIHPALDSGDGMHLNDKGAQAVANAVDLETLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U330</accession>
    <name>A0A1H5U330_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69484">
        <property type="protein sequence ID" value="SEF69484"/>
        <property type="gene ID" value="SAMN04489712_101854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF69484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="24483" checksum="3164E0160223B7E4" modified="2017-01-18" version="1">MTVPNEDTHTMRALRALESDSSSVRLQAAMAVGTTPDPRFIDKLIERCAIEPEFFVREMLTWALIHHSSSMTVPKLIDELRSERAQARSQALHTLSKIGDRRAWPAITRALLTDADDEVARSAWRAAVALVPEGEEPELADVLATQLGRGGRETQLSLSRALIALGNVIMPVLRAAMTDPDPRVRQHAIATERLSRDPEAGFEFAIEEAKRLVALGTTGQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UW97</accession>
    <name>A0A1H5UW97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_10234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78708">
        <property type="protein sequence ID" value="SEF78708"/>
        <property type="gene ID" value="SAMN04489712_10234"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF78708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="528" mass="57064" checksum="486CE5BD8E9B9CB7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V216</accession>
    <name>A0A1H5V216_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80467">
        <property type="protein sequence ID" value="SEF80467"/>
        <property type="gene ID" value="SAMN04489712_102100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF80467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="170" mass="17760" checksum="D62B1669FFF48BA3" modified="2017-01-18" version="1">MGDPLSGGPTPGPVAGEFVDAVAGFATGVVVLTVRDGRDDLGTTITSFVSVSLEPPMVLVGVASASYLAEVLGRRDRWAVTVLSAAQRALAGRFAAAGRPSARLLLASRPHHRGPLSDALVPEEGMAALECETRRRVTAGDHLLVVAEVLAVDYVHGGRSPLIRVGRRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V3S3</accession>
    <name>A0A1H5V3S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class probable F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81883">
        <property type="protein sequence ID" value="SEF81883"/>
        <property type="gene ID" value="SAMN04489712_102150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF81883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="16226" checksum="96CFDB70FC66EDE1" modified="2017-01-18" version="1">MSEDETTSFLDAQTKLHLGTINPDGTPHMVTMFHAVVDGRLAFWTYRASQKARNIARDPRVTCLVEAGEDYFELVGALVYGRAETLTEPNDVRYVGRQVVRRMLGPDHESAVEPFVDATAAKRYAYLVTPDRVVSWDHRKLTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V5R4</accession>
    <name>A0A1H5V5R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polar amino acid transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82762">
        <property type="protein sequence ID" value="SEF82762"/>
        <property type="gene ID" value="SAMN04489712_102182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009286860" evidence="4">
        <location>
            <begin position="29"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="52"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF82762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="30077" checksum="063513196E64BA71" modified="2017-01-18" version="1">MITGSLRRRVIAVGALVLAGALALSACGDDSDGGDSGGAPKVAGVKLVKDGKLTVCTSLPYPPFQYPEGGKTVGFDVDMIDLVAKKLGVTQEIVDVKFDVIKSGAALNSGRCDVAAAGMTITDERKQNLDFSAPYFPESIALLTKKGAGVTSLDQVKAQNLRLGVQTGTTSLDEAKKKGLSPKEYDDAGKQLLALQSGQIDVILQDLPVVNDWLKKPEVSGKYERSAQFPTGMQYGFAVRKGNNPELLKTIDETIKTAVQDGTWKKIYVQWIGSEPESTPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V9A6</accession>
    <name>A0A1H5V9A6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidinol-phosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_102219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83793">
        <property type="protein sequence ID" value="SEF83793"/>
        <property type="gene ID" value="SAMN04489712_102219"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011809">
        <property type="entry name" value="His_9_proposed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02067">
        <property type="entry name" value="his_9_HisN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF83793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="30119" checksum="EC547CDFCB120656" modified="2017-01-18" version="1">MPVRAVITVAWHAVAGYSDDLRLAHVLADAADDITTRRFRALDLRIDTKPDLTPVSDADRSVEEQVRGTLKRARPRDAVLGEEYGRSGHGARCWIIDPVDGTKNFVRGVPVWATLIALMERDEVVVGLVSAPALNRRWWAARGGGAWTGRSLSQATRLQVSSVAKLADASLSFSSLSGWEERGRLDGFLDLTRSVWRTRAYGDFWSHMMVAEGAVDISAEPEVSLWDLAALQVIVEEAGGVFTDLSGAPGPDGGSVVCTNGLLHAEVLQALGGGPVSVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VDI2</accession>
    <name>A0A1H5VDI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85270">
        <property type="protein sequence ID" value="SEF85270"/>
        <property type="gene ID" value="SAMN04489712_102273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF85270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="15684" checksum="C586C8EA57A5D1B0" modified="2017-01-18" version="1">MTRLAPPRPADPVPSRDGAPDRLPVSGCAVRLGTGSEGRPALEVYGPGGALIDVMVADSLGAAALRGGVRGRAGRRSAESWAVAWGHLPYGRDVPVVRFRSACGDRPGDTVVVAGAFWVSEASGPSRSVTVRAAGVRTVTARLYRIPGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VEY4</accession>
    <name>A0A1H5VEY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase of the HAD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85912">
        <property type="protein sequence ID" value="SEF85912"/>
        <property type="gene ID" value="SAMN04489712_102298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF85912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="24519" checksum="194A72D536CE3A3E" modified="2017-01-18" version="1">MNSSRKPAVKAVWTDFGGVVTPPISHTMESFCTRKDIDRDALFMAIIKVTESYGTDDYMEPIDTPLVTEREWLRQIGDILVAEHGLQGEYPTTLADDWFDGRETNHAWVEVLRGLRARGLFVGMLSNMVPTWDAHWRRMVDAGELFDDVVLSFEVGHRKPQRGMYDLAAKRAGVRPEECLLVDDTARNVEGARAASWQAVHFIDAESAGAELARLLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VLT1</accession>
    <name>A0A1H5VLT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87986">
        <property type="protein sequence ID" value="SEF87986"/>
        <property type="gene ID" value="SAMN04489712_102363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF87986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="197" mass="21534" checksum="729C250B7EF99676" modified="2017-01-18" version="1">MDSARSEQVRRMPTAVKIVIAGGFGAGKTTMVSSVSETVPLRTEETLTGRGVGVDDLAGVENKSTTTVAMDFGRITIRRDLVLYLFGTPGQERFWFMWDDVTLGALGAVVLADTRRLTDCFPSVDYFERRGTPFIVAVNCFDGARRYDLDEVRIALSLGPSVPVTMCDARDRSSAKEVLIKLAQHAMHQRVGPAVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VN77</accession>
    <name>A0A1H5VN77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88694">
        <property type="protein sequence ID" value="SEF88694"/>
        <property type="gene ID" value="SAMN04489712_102388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF88694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="469" mass="48453" checksum="F209C14536FC4C8F" modified="2017-01-18" version="1">MARVPYHWRVLSVVTLGSLMTGVNASTLNVALPVVVRHFEAGALAAHWVLLSFMLTNTVLLVLCGRLADVFGRRETYMLGYGVFTVASLLLGLAPGVGALIALRMVQAAGFAMILANATAIITHSFPPHLLSQGIGLYISTISVSQVLGPSVGGFLADAAGWRWVFWFNVPFGIAAICWGAVTLRKVPRGDREPVDVRGALLLLCWLGGLLLALSEAGALGWGSPLVLAGVLAFALGLPLFWWAQRRTAHPLIDLGLFADPGFSLANAAAFLHTLARFGIVLVAALFFQGVRGVDAATAGLAVLPVPIAMMVASPLAGTLARWVGPRTVAVAGPAMTAAGLATLLLTLDAGTPYPVVAAGLALMGAGSGVFLTGNTTAIMARVPRDRLGVVNGMRLTLQNVGNTLGVAMALSLIASAVDRADRPALFTGAAPEGTVAGYQRAMAVMLVMALLSMAAAVAGLVATRRAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VTV9</accession>
    <name>A0A1H5VTV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90281">
        <property type="protein sequence ID" value="SEF90281"/>
        <property type="gene ID" value="SAMN04489712_102443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MEDS" evidence="2">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="210"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF90281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="35149" checksum="94FA67D45836F202" modified="2017-01-18" version="1">MRTRPVAPSVSGRDVLVHRALTYGSDAELADGAVPYLRDGLRRGDAVVVITGPGNAALLRERLGAAAGPVEFVDSAAWFQAPVQTLAAYHEHARRDWWPRGRLRLLTEPVWAGRTPLEIREWKRHEAILNVAFAGTPSMICCAYDTRELPADVIEDAARTHPELVVRGAARPSPGYVDPADFYDECNAVPLPPPPREGVAERSFAGGGLPGLRDFTAAEAGRRGLPQERILPLVLAVNEVATNIIRHGGGRGRVRLWADGDELVCDVIDPARALRDRFLGYQPPQPSRPGAGMWAVRRLCHIVQIRSGDRGTVVRLHTRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W5Z1</accession>
    <name>A0A1H5W5Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94581">
        <property type="protein sequence ID" value="SEF94581"/>
        <property type="gene ID" value="SAMN04489712_102591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="93"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF94581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="345" mass="36537" checksum="3D18BEDF0C907478" modified="2017-01-18" version="1">MPQAAYYLSHWAANGRVLIVSVMRMPTICGVAAAAVVLAGCSPTELVDPEPLPETAPVPHAEDRRFDLDYAPGSPAQRLDLHVPAGTAPSPLVVYLHGGHWRDGDKSEVERDVRGELLKAGYAVASVNYRLTAEARWPAAVQDAKAAVRWLRANAGEYHLDPHRFAVVGSSSGGYLAAAVALTGDRGTIFDTSRADPPRTSDAVQAAVLWSAPVDFGSLDRQAEAAGCPPAVPAHGAADSAESAWLGEPVGRGGRKARAANLLSHVPKRPKPPFLLLHGTADCTVPPAQSQALHRALRRAGGTSTLTLVKGMDHLGTRYAKARLRATVDFLDRTLSRPAPQPHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WA23</accession>
    <name>A0A1H5WA23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system, OmpR family, response regulator MtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96314">
        <property type="protein sequence ID" value="SEF96314"/>
        <property type="gene ID" value="SAMN04489712_102643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF96314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="24971" checksum="06D4658134C9B6DB" modified="2017-01-18" version="1">MRGRVLVVDDDLALAEMLGIVLRGEGFEPSFVHDGDKALEAFRETRPDLVLLDLMLPGADGIDVCRQIRAESGVPIVMLTAKSDTVDVVLGLESGADDYIVKPFKPKELVARVRARLRRTDEPAPETLQIGDITIDVAGHSVKRADKHIPLTPLEFDLLVALARKPRQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRAKIERDPEHPEIVVTVRGVGYKAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WZS9</accession>
    <name>A0A1H5WZS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">50S ribosome-binding GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04735">
        <property type="protein sequence ID" value="SEG04735"/>
        <property type="gene ID" value="SAMN04489712_10322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045528">
        <property type="entry name" value="DO-GTPase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19993">
        <property type="entry name" value="DO-GTPase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DO-GTPase2" evidence="1">
        <location>
            <begin position="120"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG04735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="440" mass="47530" checksum="BD946DEB1D6BD3F4" modified="2017-01-18" version="1">MGRGRLSRASGPPLGRIGIPGLRGGEDVGCPYCFARVPVQRIEFRCVGRAGRAPGCAPELDERLAEYLGSTAGASLPPVFAAPGRGGRADCPRCGRTTGRRVCPHCHNPLPSAYCEAPGRIVALVGAKNAGKSTYIAVLLHELMNRVGTELDASLVACDDRTIDRYKRDFARPLYEERRLLPTTASAATAPREPLVYLLTRTRRARRRPPAQMARLARLAGRERTESLALVLFDTAGEDLRSREVRDLHLRYLEAADAIVFLVDPLELPGARAAVRDEAAAALPAAPPDPDGEPINVIARVTEALRQRRGTRPGERLPVPVAVALTKIDALAPALARQSALHRSRPSPGTLDLDDREAVDAQVRGLLHQWQAGQLDVYLRQQYAEYALFGVSALGGMPSDGRVGTGGVRPHRVEDPLLWLLYRFGMLEGTRGAVTDGNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X501</accession>
    <name>A0A1H5X501_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-dehydro-2-deoxygluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06824">
        <property type="protein sequence ID" value="SEG06824"/>
        <property type="gene ID" value="SAMN04489712_10390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030830">
        <property type="entry name" value="Myo_inos_IolC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04382">
        <property type="entry name" value="myo_inos_iolC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG06824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="34392" checksum="3F14297358DE0064" modified="2017-01-18" version="1">MASDDLITMGRVSVDLYPHQVGAALEDVESFGRYLGGSPTNVAVAAARHGRRTAVITRTGADPFGRFVRRALREYGVDDRFVTEVPGLPTPLAFCEIHPPDRFPLYFYRYPRAPDMQIAPDELDLDAIGAARILWATVTGLAEQPSRDATLAALAAHPGTTILDLDHRPMFWPSPREARRWAAEALRHATVAVGNLDECEVAVGEREPWRAARALLDRGVELAVVKQGPQGVLAVTGHESAEIPPIEVEVVNGLGAGDAFGGALCHGLLAGWDLARTVRFANAAGAIVASRLACSPAMPTTAEVERLIEGNGRCSHGATRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X965</accession>
    <name>A0A1H5X965_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ORF">SAMN04489712_103148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08282">
        <property type="protein sequence ID" value="SEG08282"/>
        <property type="gene ID" value="SAMN04489712_103148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG08282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="211" mass="22549" checksum="E7B6D43BE52693A7" modified="2017-01-18" version="1">MSLFRLDASIMPATSASAELADLVEAEWSAARPGEPVVRRHLGTDPLPADAWTHAATAGFVPEDQRTPAQRDALALAAALKAELADADAVLLAIPLYNYGVSQHVKTWIDLVTVAAGTAGPGFLQDKPTVLVTVRGGGYGPGTPREGWDHSTPYLRRVLADMWEAELTVVERELTLVGVNPALDHLKDIAVQRHAEARDAAHRTGRALAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XQV5</accession>
    <name>A0A1H5XQV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Phosphoribulokinase</fullName>
            <ecNumber evidence="3 5">2.7.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phosphoribulokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.19" evidence="3 5"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13780">
        <property type="protein sequence ID" value="SEG13780"/>
        <property type="gene ID" value="SAMN04489712_103354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008974">
        <property type="term" value="F:phosphoribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006082">
        <property type="entry name" value="PRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00478">
        <property type="entry name" value="PHRIBLKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00567">
        <property type="entry name" value="PHOSPHORIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="6">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG13780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="316" mass="35621" checksum="3AF1B416E35B4860" modified="2017-01-18" version="1">MPHRIVHMLRARGSARRPVMLAIAGDSAAGKTTLTRGLVQCLGADRMTAVCVDDYHRYDRAERRDKPFTALHPDCNHIDIMEQHLQLLSMGEPILKPVYDHSTGELVRPELVEPRDFVIVEGLLPLHTRLARACFDITVYLDPPETLRHQWKIQRDCAKRGYTPEQVRAELARREPESAAYIRPQRRWADIVVRFAPVAGRADPPDTPLSAELLLRPTIDHPELRGVLDDAEHRAMHLKLHRDTDGRPVDALHVHGYVSPEECQVVKKAIWERLGTGTTLPGSLGRLADGADSDPLAITQLLLLYHLLDANRRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XU14</accession>
    <name>A0A1H5XU14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FG-GAP repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14880">
        <property type="protein sequence ID" value="SEG14880"/>
        <property type="gene ID" value="SAMN04489712_103397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289845" evidence="4">
        <location>
            <begin position="34"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG14880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="494" mass="49336" checksum="558DADA4CDC2DEAB" modified="2017-01-18" version="1">MRSRVFARATALAAVTALGGLGLAGLAPSASAAAPAKAYDFNGDGYADLAIGSPNGKVGSKAGAGFVSVVYGSAAGLNTGKKKVFTQNSAGVPGAAEAGDHFGHSLASADFDRDGYADLAVGAPDEDTADGANAGTVTILWGTRSGLTNRATASGEFGQAGAGHRWGESLAVGDIERDRSPELFITVPGVSSFKWYYFNETAAASAGAVRPGGAKGLVRGGGVSAQSPQDVNSSWVASGDVTGDGYDDLVYAWNDADWHVPAERRGFVVFPGTAGGDLLNGRAVLTEVRSLAVGDFNGDRARDVAVGQGSPKGGRVVVFPGSATNVDPATKTSIDLDTPGVPGVAVAGDGFGSGIAAGDVNKDGKADLAVGVPYAQVGGKKVVNAGRAYVLFGSAKGLTGTGAQTVSQNIAGVPDGAERNDNFGYQVTLLDHTRDGYADLVVGAPGENSPNGAVTFIKSRGARGVLPVAGAKAIGTGTFGVTGKNAQLGRLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YJI5</accession>
    <name>A0A1H5YJI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23536">
        <property type="protein sequence ID" value="SEG23536"/>
        <property type="gene ID" value="SAMN04489712_10417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="23517" checksum="3B25781BBFE7170C" modified="2017-01-18" version="1">MKAPARHTGPAGDTDPIEGYLAALTTALRGPARAKARMIEEMRDGLVETAMAYTDEGMPYRQAAGEAVREFGSPEEIAPSCQRELTIVQARHTARVAALTVPLLFACWYLVRTTGQGWQPPGAALLPAGVAATAALLASATLAATGTLARRLPTPRRLPLAVAWTGTTTAVAMALTALAFAVTSPPAVDWPLVALVAALAVASHAVIAASARVCRECARLSAAPSGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YKN0</accession>
    <name>A0A1H5YKN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23936">
        <property type="protein sequence ID" value="SEG23936"/>
        <property type="gene ID" value="SAMN04489712_10436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="309" mass="33414" checksum="4A2E0A97D0050A8B" modified="2017-01-18" version="1">MSAEVTAGHGPRRSPLERRYEALLRIYPAAFRDRHGADIIGTLMETSTPGRRVPSPRETASLIREGLAARARQATESPVRWWADGLHLGVLILAVVHLVHVGADIVLQGRSSWPWVAVSMALTLALLRGRLWAALPLALGSAFVVSRAMLFGYAASADWPLLSNATVYHSWISLTPYWLMAAGVVVLAARRSRELQPRSWWWLALPVATFAGDALLGVDLYSELGSLGRAGLEGGLLLAGIWVTTVTRSPRWALAAAIYVLPGELSTIADLPQTLKSPMVTAYWAVLAVLLLAMAWIASRVRTDTGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YQH3</accession>
    <name>A0A1H5YQH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type I restriction enzyme, S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25972">
        <property type="protein sequence ID" value="SEG25972"/>
        <property type="gene ID" value="SAMN04489712_104114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG25972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="30797" checksum="E3833C4E871CB4DF" modified="2017-01-18" version="1">MEEQRRIADFLDVKTAHIDKLHAFRGQQLRDLEERELAIIADMLSGGATSEDGRPTGWPWLPHIPQDWSIGPVYAYFYTELGKMLNPDRSRGSNQRPYLRNANIHWYEIDTSDVATMHFDPDEVKRYSLSPGDLLVCEGGAGVAEAAIWDGRIAECFFQKSLHRVQRSGKVPVEWLMYWLRFAKSCGVFEAGGNIATIPHLTGEQLRQYRIPIPNNGETLIRRTEQTIKAMAKVRMALNQAQELLAERRQALITAAVTGQFDVASASGRGVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z4A5</accession>
    <name>A0A1H5Z4A5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein SAMN04489712_104342</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31171">
        <property type="protein sequence ID" value="SEG31171"/>
        <property type="gene ID" value="SAMN04489712_104342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG31171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="162" mass="17996" checksum="8E59579F50D6CA1B" modified="2017-01-18" version="1">MADSSFDIVSKLDRQEVDNAVNQAAKEVANRFDFRNVDAGIKWSGDSIEIQANTEERANAILDVLKDKLVKRGVSLKVLEAGEPRLSGKVYKLGVSLKEGISQENAKKISKIIRDEGPKGVRAQIQGEELRVSSKKKDDLQQVITLLKGKDLDVALQFVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZED9</accession>
    <name>A0A1H5ZED9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">guaB</name>
        <name evidence="16" type="ORF">SAMN04489712_104479</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34007">
        <property type="protein sequence ID" value="SEG34007"/>
        <property type="gene ID" value="SAMN04489712_104479"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="99"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="159"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="343"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="366"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="390"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SEG34007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="500" mass="52732" checksum="EFCED0730B49B3FF" modified="2017-01-18" version="1">MNPAAEPAKFLPPGLTFDDVLLLPAYSDLQPGEADTTTRLSRNITLRIPLVSAAMDTVTEARMAIAMARQGGIGILHRNLSIAEQAEQADMVKRSENGMITKPVTCSPDDTLADVEQLCARFRISGVPVIDSGGVLVGIVTNRDTRFESDPSRLVREVMTPMPLITAPVDVSRDEAFRLLAHNKIEKLPLIDGAGRLRGLITVKDFIKSEQYPDATKDADGRLVVGAAVGVGEDGIARAQALVEAGTDVIIVDVAQGHSKGVLDTIAKIKANTRGVDVVGGNVATYEGARALVEAGADGVKVGVGPGSICTTRVVAGVGVPQVTAIYEAARAARPAGVPVIGDGGLQYSGDIAKAIAAGASSVMLGSLLAGVEESPGELIFVHGKQYKSYRGMGSLGAMRNRERGRSYSKDRYSQADVNSEEKLIPEGVEGQVPYRGPLAAVAHQLVGGLQQSMWYAGTRTVPELQETGRLMQITAAGLKESHPHDVQMIVEAPNYQGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZXJ9</accession>
    <name>A0A1H5ZXJ9_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SEG41179"/>
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            <begin position="1"/>
            <end position="96"/>
        </location>
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            <begin position="1"/>
            <end position="30"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="62"/>
            <end position="88"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG41179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="10226" checksum="7461133F3AEA6B6D" modified="2017-01-18" version="1">MTSPEDDDRRESRPQQDRGPGAHSGHERQVQERVVPGTASAAEGYQTGEDDILAGVRARPGETARPADEEETGTPSGDRGEEPPEDEGQPSFGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1L0</accession>
    <name>A0A1H6A1L0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan/xylan/chitin deacetylase, PgdA/CDA1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
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            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SEG42619"/>
        <property type="gene ID" value="SAMN04489712_105149"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
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        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292208" evidence="2">
        <location>
            <begin position="28"/>
            <end position="353"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="234"/>
        </location>
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            <begin position="33"/>
            <end position="55"/>
        </location>
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            <begin position="248"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG42619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="353" mass="38290" checksum="600670C4CECD7436" modified="2017-01-18" version="1">MVRNRRSAVLVAVAVGACLLSACGQDAQVRTASRRTKAPDGAVARPRQTPSTPPVDCTRAKCVALTFDDGPGPYTGRLLDDLAKARARATFFVLGAHVGPNAELVRRMVAEGHDVGNHTWSHPYLPRLSEAEARSEVQRTQEVVQQVAGVRPTIFRPPYGATNAQVGNAAGLPQIMWSVDPMDWRRPDAARTTQVVLRDTRPGSIVLLHDVKEASVAAVPGILAQLSGRGYRFVTVSELFNGTPLQPGRLYTGREAPPVRERAEDAGGTTLPATRTSRGTSTTSPVRRRTVSTSPVHDSRTPTTSLYPPVGSRRRSETRSPTSACEMETTSRAAKRADMWRPPSRMDISLPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A368</accession>
    <name>A0A1H6A368_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_105182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43169">
        <property type="protein sequence ID" value="SEG43169"/>
        <property type="gene ID" value="SAMN04489712_105182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="4">
        <location>
            <begin position="168"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG43169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="27696" checksum="DC9DAA7E288B7556" modified="2017-01-18" version="1">MSVYEPGSFLAELTVEERGDLLGRGRERRVERGETLFVEGESTTWVAVLLSGTVKACSYGDNGIEVVLAVRGPGALLGEVSAIDGLPRSATVSALERASVRALRAEEFMDFLHGHSRVSVQLMRMLCQRWRDADRKRIEFGMFDTTGRVAQRLVELAERYSEPYEPRRGAERAVAGRVPGPREPRGLSQPPGSVRITLNLTQEELAGWVGASREAVSKALRTLRGHGWIETGRRRVIVHDLQALRRHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A8H7</accession>
    <name>A0A1H6A8H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44036">
        <property type="protein sequence ID" value="SEG44036"/>
        <property type="gene ID" value="SAMN04489712_105229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="93" mass="10351" checksum="57CF46A08B705651" modified="2017-01-18" version="1">MLLHTMASISDQILASPDDLQTDNLADWLRQIFGPLFLVIVSIVAIFFLFTREITRFVQFIVLAIGIGIIFYVPNIIETTAKAIARALGVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A8N4</accession>
    <name>A0A1H6A8N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45098">
        <property type="protein sequence ID" value="SEG45098"/>
        <property type="gene ID" value="SAMN04489712_105286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG45098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="513" mass="55760" checksum="388AF8304F420DD7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AA79</accession>
    <name>A0A1H6AA79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PhoH-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45659">
        <property type="protein sequence ID" value="SEG45659"/>
        <property type="gene ID" value="SAMN04489712_105316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG45659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="443" mass="48390" checksum="7F7CC50EE98CB312" modified="2017-01-18" version="1">MATSSRRRDTEQPQRRTYVLDTSVLLADPGAMTRFAEHEVVLPIVVITELEAKRHHPELGYFARQALRILDDLRVEHGRLDEAIPLGELGGSLRVELNHADPGVLPDGFRLGDNDTRILSVAAWLAREGKDVVLVSKDLPLRVKASAVGLAAEEYRAELAVVESGWTGMRELEATAAQVEELYDTGSLDLPEARELPCHTGLRLLSERGSALGRVQPDKSVRLVRGDREVFGLRGRSAEQRVALDLLMDEDVGIVSLGGRAGTGKSALALCAGLEAVLERRRHRKVVVFRPLYAVGGQELGYLPGSENEKMSPWAQAVYDTLSAVTTPEVIEEVLDRDMLEVLPLTHIRGRSLHDAFVIVDEAQSLERGVLLTVLSRIGAGSRVVLTHDVAQRDNLRVGRHDGVVAVVEKLKGHPLFAHVTLTRSERSPIAALVTDLLGDVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABC9</accession>
    <name>A0A1H6ABC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45056">
        <property type="protein sequence ID" value="SEG45056"/>
        <property type="gene ID" value="SAMN04489712_105284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG45056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="105" mass="10576" checksum="BBB025FED261F62C" modified="2017-01-18" version="1">MAIVVGTSLDAAATPGPGAVVDCEATTYRLHTAIVTVAGTAVTDVQVALEVSHNTTDWALAETLALPGAGCQQVTFSSAARYLRANLTTLNGDADTTVTAVISNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AEP1</accession>
    <name>A0A1H6AEP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46740">
        <property type="protein sequence ID" value="SEG46740"/>
        <property type="gene ID" value="SAMN04489712_105380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG46740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="27297" checksum="2E9F455E709ED708" modified="2017-01-18" version="1">MPTLQRQPTVSYDSQQFERRIREYAAERPGMRLRILEAGCGRRWTLDLEGVDYHLTGLDANEHSMRMRIDEVGDLDEAIVGDLRTAELELGSYDVVFNSFVLEHIAGARQVLDLMVGALRPGGLLLLRIPDRDSMYGFITRHTPHRLHVTYKRRIRGKKLAGTPGRGPFPTVYDKVVSYRGIVDYCASAGLVIESAYSSNHHIDFFGRLAPVVDRGLRTAAALSFGRLTADHSNLSFIIRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AW60</accession>
    <name>A0A1H6AW60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52450">
        <property type="protein sequence ID" value="SEG52450"/>
        <property type="gene ID" value="SAMN04489712_10632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="385" mass="41947" checksum="3921F4FA44AF3578" modified="2017-01-18" version="1">MALKRHRLAQRRRAFGHSQERLADLLGIERSTVGRWERAETSPLPYIRPKLAAELRITLEELADLLDEVEPADGDGNEHLDQVLSNPASVDLITTAHLWQRVQALTDEYDHVPSALLLAAAGQCHGQVSYLRQNAASNRVRRELFAVEAESATLMGQLVWDACQRRDHATSLRYFNEAITAARQIRDRFTEAHAQLRKSYVALYGHGDSHNGLGLAKSAARTVADTSPSLAGIALMHVGEAHAMLGEHGRCHAALEAAQSHFVRADDADPAGEFFTPTDHARLTGSCHLYLGSPASAVSTLAALPQDGSKSDAIVLGNLSLAHIRLRNLDEAVASLHQAITVVEGTRGGGGLNLVFTAGRELHPWRRERPVQEITDRLLALMSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B0J7</accession>
    <name>A0A1H6B0J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54164">
        <property type="protein sequence ID" value="SEG54164"/>
        <property type="gene ID" value="SAMN04489712_106140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG54164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="21630" checksum="69C96D5E1B1D4B2A" modified="2017-01-18" version="1">MVVDARDVGVELGGGRVFAGVGLRVDRGDIVAVVGENGAGKSTLLRCLAGLQPGVSGQVVVFARPPADEPGFWRDVALVGDEPAWYPGLTVREHLELMPAVHGAARMGVDAALETFGLAGQGDRAPLALSTGQRQRLLLAMALIRPSRLLLLDEPERGLDPAFRERLAASLCEYAEEGGTVVMATHDLQLAESTRARRLTLQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B221</accession>
    <name>A0A1H6B221_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Red chlorophyll catabolite reductase (RCC reductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54859">
        <property type="protein sequence ID" value="SEG54859"/>
        <property type="gene ID" value="SAMN04489712_106185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051743">
        <property type="term" value="F:red chlorophyll catabolite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009439">
        <property type="entry name" value="RCC_reductase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06405">
        <property type="entry name" value="RCC_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG54859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="30598" checksum="CAAD492A5797AFDD" modified="2017-01-18" version="1">MKETLQHVEQMLDQSPVIDVTETFHRFESILAGLKEKIDARFELTRDPSTEPLESYGTYPDGPGGRLAAYSGPEVDWMVHSWLGNPKASFANLHLTVWLGPHIRVPHLGIAMLVWPEGWFYVDSIPRTNLLVDGEYYDKYYEPLNDGWLAFREENPEFEWFTSRAGFIRTSLSPTAHCYSFPRAEKNIDLVGRVLDEHVDRWLGWVAEAEPVPEDERAALAATDLAIRRNIAERDPANVMGVRYFGQETTDRLVRALWGGDRELPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3U6</accession>
    <name>A0A1H6B3U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chloramphenicol phosphotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55065">
        <property type="protein sequence ID" value="SEG55065"/>
        <property type="gene ID" value="SAMN04489712_106201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG55065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="19776" checksum="1FB1BC763726034C" modified="2017-01-18" version="1">MVRELDGAVVLITGIMASGKSTVAQLLAERLPRAVHLRGDLFRRMIVSGRAEMTPEADAEAVAQLRLRYQASASVADLYAQAGWTVIVQDVILGEHLNEYLAALRSRPLYLVVLVPDAQAVAAREAARAKTGYGAWAVEALDDALRHQTPRRGLWLDTTHQTPDQSVRAILADLEKARIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BFP5</accession>
    <name>A0A1H6BFP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR C-terminal helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59066">
        <property type="protein sequence ID" value="SEG59066"/>
        <property type="gene ID" value="SAMN04489712_10744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="410" mass="44582" checksum="29CBB5B96AC50E76" modified="2017-01-18" version="1">MPSTTTLIPDENMAAVAAAASRRLLERLDDLTDRLVAEILAEDSGYAGFVPHDDLWRTVHGILGESIDHMGRRALGEEPAVEAAVSIGRRRAEQGLPLESLLRSFRIGGRLTWEAMIEVVAEEDPGSLPALLRFASIVWHTNEVQSNAVAESYRRTESELLRRSDERMAALLDALLEGRGADGGLTKAAAAALDLPVHGRYAVAVLRSPRRDPGFERPGRAGGLRFVWRMRADTEMAVVELGERHPADAAAALEPLFTGEAGISPAVDGLAALGRARWLAEVALQTCRPGDRRIARLDERLPAALVVSQPELSGYLGDTVLGPLADLDPVDREVLLETLATWLDCEGSAARTAGRLYCHRNTVFNRLRRLEQLTARSLHRPRDVVELALALDALDLVAAGDPAARERRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKU8</accession>
    <name>A0A1H6BKU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61320">
        <property type="protein sequence ID" value="SEG61320"/>
        <property type="gene ID" value="SAMN04489712_107203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293978" evidence="2">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG61320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="421" mass="45355" checksum="17F8FB21460D441D" modified="2017-01-18" version="1">MRFIKIAATAAAIALAATACGGDEGNDEAGAAAPAKLNVWMMGEGTPEQTAFLDGVETEFRKKHPNTDVVIKYVPWPQVATTFQKAIAGGEGPDVTEIGNTDVQSHIEQGNLADISDNFAKWADGASLNKTALANDQGDGKTYAVPWYGGVRGVWYRTDWFSELGITPPKTWAELTAAAKKIQDEKKVPGIGAPSDQTNAIMSFIWGNGGDVAVKEGDKWVGKLDQPQVKEAIDFYAGLVTTEKVAPEKYIGKNELQGPQQDFALGKLGMYIDGSWALKEMKKVSEKNADKWSVFPIPTKTGGNAPVMAGGSDLAVWKNTKAKDVAFDYITVLNNKTNAQKWADYSGFSSMFTDVKFTDPKLEAFTAIAANTKMAPLSTGWADFEQTKKVIPNTVKGVMQGKPSADELKKANEQANTLLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BMD5</accession>
    <name>A0A1H6BMD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminodeoxyfutalosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61843">
        <property type="protein sequence ID" value="SEG61843"/>
        <property type="gene ID" value="SAMN04489712_107250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG61843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="338" mass="36510" checksum="467959F88CF4BFC5" modified="2017-01-18" version="1">MTWIYDFIDLLPKVELHVHLVGSASVQTVLELAAGHPDSRLPRTPEGLRGFYKFRDFRHFAEVYQAVSDVVRRPEDIATLVLGAARDLAAQRVRYVELTVTPYTHVLAGMSMPAVTEALDVAARQASERHGIRVAYIFDIAGQHGGAGARATVDHALHHPPERLVGLGLGGVEQVRAAHADAFRDAFRAAVAAGLHSLPHAGEMTGPETIWEAIDGLGAERIGHGISCLDDRRLIDHLRETRLPLEVCPTSNVRTGQVAEHAAHPLPRMLEEGLYVTLNSDDPPMFGTSLTGEYRVAADVFGLGPGDLADLARNAVRASFLDAVGQAEILTEIDTVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BQD1</accession>
    <name>A0A1H6BQD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62842">
        <property type="protein sequence ID" value="SEG62842"/>
        <property type="gene ID" value="SAMN04489712_107326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG62842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="28511" checksum="295856E773158B6F" modified="2017-01-18" version="1">MSGWNPPPGQGGDPYGGPPGPGQQPGYGPPPGGQVPPYGQQPPYGQQPPAYGQQPPAYGQQPGYGPPGTPPPFPQPAPPRRGPGAGLIIALVGGGVVLVLILVVVVVAIGSGSKHTITTPPSAGGLTRNHAAESELSSQISQQRSVMQRSAGYRLDDLKTAVYGTGTQRYLFMGGTGNIESPDDFVDNFRKSATSGSSSLVNTTVNELDDAGGDGVGVCAEIRSTAGTSSTTSALCAWATDSSFGAVFPAPDRASVTSSTSYSASEVADVMRRLRGDVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BR86</accession>
    <name>A0A1H6BR86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidoglycan glycosyltransferase RodA</fullName>
            <shortName evidence="7">PGT</shortName>
            <ecNumber evidence="7">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cell elongation protein RodA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Cell wall polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerase</fullName>
            <shortName evidence="7">PG polymerase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rodA</name>
        <name evidence="8" type="ORF">SAMN04489712_107317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Peptidoglycan polymerase that is essential for cell wall elongation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SEDS family. MrdB/RodA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62726">
        <property type="protein sequence ID" value="SEG62726"/>
        <property type="gene ID" value="SAMN04489712_107317"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02079">
        <property type="entry name" value="PGT_RodA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG62726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="404" mass="42301" checksum="A51CD91DB5A14149" modified="2017-01-18" version="1">MIGGLGGLGAADVVEGYGARQTWRYRLATLRRLDWTLILAVVALSILGALLVRSATVAILTEQGKDPEGFFKRHLFNLAIGFTLGGVVAMLDYRLLRAYTPIVYGLACLGLVAVLSPLGETINGSHSWIVLGGGFQVQPSEFAKVGLVVLLAMLLAEPRDGEPRDTDSGPGARDIVLALALAGGPAVLVMAQPDLGTTLVFGAVVLGMLAMSGVRKRWLAGLVGSALLAAFAVWFFGLLKPYQIDRFTAFANPEADPRGAGYNAQQARIAVGSGGFTGKGLFEGEQTGGHFVPEQQTDFIFTVAGEELGFVGAGLIIALMGVVLWRGLRIATAAADPFGALVAAGVVCWLAFQTFENIGMTLGIMPITGLPLPFVSYGGSATFANMIALGLLQAVHLRARPFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUG9</accession>
    <name>A0A1H6BUG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64381">
        <property type="protein sequence ID" value="SEG64381"/>
        <property type="gene ID" value="SAMN04489712_10819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="17"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="201"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG64381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="39920" checksum="C324058A4CA6CE0B" modified="2017-01-18" version="1">MKLDGLRVALVLGSSAGGVGRHVRSVAEGLAGRGARVLVCGPAGTEELFGFTAAGARFVPVDIADRPRPLADARAVARLRTLLRDADVVHAHGLRAGGLAVAACARVAPGPLRIARGGIPVVVTLHNALLAGGVTGAAYRTLERIVAAGAHQVLGVSPDLEARMRGLGARRVGLALVPAPAAGPPPGPEARARVRDELDVGDRPLILTVGRLAGQKGLPTLLDAAAGWARRTPRPLVAIAGDGPLEGELRARIEAEDLPVRLLGRRSDVPGLLAAADVAVVPSVWEGQPLIVQEILRAGRPLVATRVGGIPLMVGAEDAGTAGGGADHAGGAVAGLLVPAGDAAALERAVARVLDEPELAARLGAAAARRAALLPTEDEAVDGLVRIYRELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BWM7</accession>
    <name>A0A1H6BWM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65101">
        <property type="protein sequence ID" value="SEG65101"/>
        <property type="gene ID" value="SAMN04489712_10877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG65101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="546" mass="56311" checksum="1BECAC0B640DAE20" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BX36</accession>
    <name>A0A1H6BX36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65017">
        <property type="protein sequence ID" value="SEG65017"/>
        <property type="gene ID" value="SAMN04489712_10871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039248">
        <property type="entry name" value="Ptase_RsbX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35801">
        <property type="entry name" value="PTHR35801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="153"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="353" mass="37347" checksum="D213E5E21A1EFDD7" modified="2017-01-18" version="1">MDPLTGGWMTDPAADEVIRTPVEEASVAARLRRLVAQLAERLGFPPERVARLQLAVSEAASNLSKHAQQGELLLRVVRDADHAAIEMVCTDSGPGIADVPAVMVDGQSSTGTLGIGMGMIARIADHSHVYSLPRRGTVLIARFEAVPGTFAETPHAGLNRPITGEEQCGDAFAASQVDEVVYAMLCDGLGHGPLAALAAREAVRAVQDSPLPMRPADLLQRVHQRLGRTRGGAVAVAAINGRTRRVDFAGLGNVAGWIVDGERRQGMISVPGIAGHQARGLREHRYELPPGAVVVLHSDGLTSRWGPHDFPGLSAQAPLVIAATLLRDAGVRRDDRAVLVVRPPDRTSGVDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C3L1</accession>
    <name>A0A1H6C3L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL-like Lipase/Acylhydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67277">
        <property type="protein sequence ID" value="SEG67277"/>
        <property type="gene ID" value="SAMN04489712_108271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294449" evidence="1">
        <location>
            <begin position="30"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="36"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG67277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="27007" checksum="94D7055364AA76B0" modified="2017-01-18" version="1">MRVPRLALAAVCAATLTIGLTATARSASAAAVNYVALGDSYSSGLGAGSYDSASGNCKRSNNAYPKLWANANAPASFRFVACSGATTTSIASGQLGALSSATTLVTVTAGGNDAGFANVMETCVLGSDSTCINAVNNAKAFMQNQLPGRLDTLYGAIRSKAPSARVVVLDYPRLYKIVNVCVGLSNTKRTALNGAADLLDSVIAGASGRANFTYSGVRDEFAGHELCSGHDWLNSVTIPIDNSYHPTALGQRSGYYAALNSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C869</accession>
    <name>A0A1H6C869_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69093">
        <property type="protein sequence ID" value="SEG69093"/>
        <property type="gene ID" value="SAMN04489712_10948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="115" mass="12572" checksum="FD3D2D927A21EC1C" modified="2017-01-18" version="1">MIYHLAADLTFDCADPDGGTDEDFDQFTDAIADELLDLAEVDPGIVDPDVTVRIADRWVSVLMGIEADSEDDAFRLFAANLRAALHAAGCGTAEWPTFKPRTRDPKVRRTQFAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CD74</accession>
    <name>A0A1H6CD74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative drug exporter of the RND superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_109207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70812">
        <property type="protein sequence ID" value="SEG70812"/>
        <property type="gene ID" value="SAMN04489712_109207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="206"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="728"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="766"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG70812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="853" mass="92309" checksum="6DBA72BD54A8AC5E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDZ5</accession>
    <name>A0A1H6CDZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase PrpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71229">
        <property type="protein sequence ID" value="SEG71229"/>
        <property type="gene ID" value="SAMN04489712_109252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG71229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="27637" checksum="63A6F41D53E98C8F" modified="2017-01-18" version="1">MNVTIKYAAGSDIGCVRENNEDSAYAGSRLIAVADGMGGYAGGEVASSTVIGSLRSLDADVPVDDLEDALGRAVAEANEKLRIAREERPDLSRMGTTLTAMLWSGAHIALAHIGDSRGYLLRDGELFQITKDHTMKELLNPDSGDGPDDGGEASRLSHVLYRVLDGREDRDPDLRRREALLGDRYLLCSDGLSGVVDAQTIYEVLSEEAEPADAIGRLIALAREGGGPDNITCVIADVVEGDPNSTMRDPQIVGAARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEP7</accession>
    <name>A0A1H6CEP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-CoA:diacylglycerol acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.122</ecNumber>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_109275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:23472"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:18195"/>
            <dbReference type="ChEBI" id="CHEBI:18234"/>
            <dbReference type="EC" id="2.3.1.122"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mycobacterial A85 antigen family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="4"/>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71481">
        <property type="protein sequence ID" value="SEG71481"/>
        <property type="gene ID" value="SAMN04489712_109275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294850" description="Acyl-CoA:diacylglycerol acyltransferase" evidence="7">
        <location>
            <begin position="37"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG71481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="341" mass="37437" checksum="752A48F3D141AAFF" modified="2017-01-18" version="1">MPARSRRRLTRRVGAITAAAIIGPLAMTAATGPVQAATYKRASNGATVAGVKWIKKGSQFDITINSKALGAKAKVRVLVPKTWKRTAKRTWPVLYAYHGGRDSYLSWTRSTDIEGMARKYDVMVVMPAGNNGSYTNWWNDGRGGKPMWETFHTLEVRELVERNFRAGGARACMGNSSGGQGCVTYAARFPKMFRHAASFSGPLSILSPGLPSLLLYTMSGTPGVDPYDVYGDPIIDRANWKAHDPASLASKLRGTKLYISSGTTGQPGPYEKPGMAPWDVGLTSEKAIGYSNQVFLNKARQLKLPVTANLYGNGRHSWPYWIRESNKVWPTLMKSLGARRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM02</accession>
    <name>A0A1H6CM02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73665">
        <property type="protein sequence ID" value="SEG73665"/>
        <property type="gene ID" value="SAMN04489712_110139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="20934" checksum="A9DD0579479429BA" modified="2017-01-18" version="1">MPRITAPTVAEHRARRYRALLEAAREIVLTDGPQAVTPAAIGARTGLARSSVYKYFPTSLDILVRLLEEVFEQWIARLGEVMAEQATSAGRVTAYVRAFLEFASGDEHRVADAIGFTGLPPEAAAKIRARHHELTEPLRRALADLGDPAPEVTMELMVGTLNAATRLIARGHPQDQIITATLAFIHPGPNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMJ5</accession>
    <name>A0A1H6CMJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_110198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74192">
        <property type="protein sequence ID" value="SEG74192"/>
        <property type="gene ID" value="SAMN04489712_110198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG74192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="30279" checksum="CE611959860F7055" modified="2017-01-18" version="1">MVEQAFNGLVSGAFYALLALGLAVIFGMLGVVNFAHGAFYMLGAFGAFVLLDSFGIGFWAALLIVPVLLGLAGVVLERLFIRRLAALDPLYNFLLTFGLALILQDVVRSRYGVQSQQYGRPGLLDGSLNLGLFEYPAYQVFVLALSALVCGLVWLALTRTKVGMIVRASTEKPELTRALGIDVARWVTPVFGFGIALAGLAGVLAAPMRAINPLMGADLIIVVFAVVVIGGLGSVFGSVAAGFLIGLISALGNLYVPALSQTLVFILMAAVLLWRPAGLFGREEGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CWE1</accession>
    <name>A0A1H6CWE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_111239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77033">
        <property type="protein sequence ID" value="SEG77033"/>
        <property type="gene ID" value="SAMN04489712_111239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG77033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="630" mass="66777" checksum="AB8115BAA1B582D6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CWR2</accession>
    <name>A0A1H6CWR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76836">
        <property type="protein sequence ID" value="SEG76836"/>
        <property type="gene ID" value="SAMN04489712_111213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="121" mass="13364" checksum="963B7714F3484C8A" modified="2017-01-18" version="1">MTGFAELAMVNLDCADPRALAEFYHQILGWEITHAEDDYAMITGPGAPIGFGRVDGFRPPNWPEADSPKRYHLDLYVNDLDEAEASCLKLGAAKPDFQPGGDRWRVLTDPAGHPFCICLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CX51</accession>
    <name>A0A1H6CX51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77085">
        <property type="protein sequence ID" value="SEG77085"/>
        <property type="gene ID" value="SAMN04489712_111246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG77085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="247" mass="25928" checksum="91F7D9571670B9CD" modified="2017-01-18" version="1">MKVPAAGPSRTAFVTAADDLADRVLSALRGAENAPFLARHVEQAPDRGAALAAVRLVGADVFVPHLLAGFPLDGQDAAAVTRSLAVFPQEAVIAGAGDAGSAVAWRDWAVAELLTRFDGGRPAVPPGEEPAEDPAATGWRPWCARMAGLSPLAIAGLDGPVHQAARCGALPLSRGAARSMLRRDYLTAVRLIRWLAWLHHDGVPLPLDLEAALDHAVLLGGHGPRTALDIAVAERLLGRPDDAHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0U8</accession>
    <name>A0A1H6D0U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78658">
        <property type="protein sequence ID" value="SEG78658"/>
        <property type="gene ID" value="SAMN04489712_112107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="190"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG78658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="352" mass="37806" checksum="285A65433A0DA95E" modified="2017-01-18" version="1">MSKVRVAVIGCGWWTTFAHLPAIAGHPDAEIAALADPDRHRLAAAAEAFEVDATFATAEELLNEVKADAAVIAVPHTLHYPIARLTLDHGLPTLLEKPMVIEPRHGRELLALAKRRDAELLIDYPWHYNRHALTIRKELADGVIGPIEHVSCLYASSVRELYRGNPEPYRDLWGYPVNAPGASTYSDPALSGGGQGQTQITHAAALMLWLTGLRPRGVSAFSANFELPVDLADGVAIRFDGGAIGVLSSTGAVLPGHDEIARFEIFGRDGHVLFDVNRGTASIHVAGMTKNLLELPHEQRNPEHAPAHNLIDVVLGRASNGSSGEIGLGAVEFVAAVYQSAREGRIVDPADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1Q1</accession>
    <name>A0A1H6D1Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_112117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78725">
        <property type="protein sequence ID" value="SEG78725"/>
        <property type="gene ID" value="SAMN04489712_112117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG78725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="24546" checksum="9B8FACED043D0B10" modified="2017-01-18" version="1">MNRAEVGTSRKESQANRIARLLVEDIRRGTYPVGDRIPSERRLAERFGVSRPVIREAVSTLTGYGLLEVQMGRGTFVTGQPTDGTPAERLSLQDVVNVREVLEVGALRLSARQGSDQAKAKVAAILDELSRAVAARAETAELDSALHAAVVEASGSPLLVSLCQGLQQQIDATIRISPHGHSMSAEILALHRVLADGVLHDRVEEAVDACRQLYEEHREFLRGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2X2</accession>
    <name>A0A1H6D2X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79394">
        <property type="protein sequence ID" value="SEG79394"/>
        <property type="gene ID" value="SAMN04489712_112209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="45" mass="4736" checksum="A95A91A9AA315D7E" modified="2017-01-18" version="1">MSGMPMMPGAGGGKDGEKERERTTWLTEDEDVWGADGDTAPPVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5G8</accession>
    <name>A0A1H6D5G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80481">
        <property type="protein sequence ID" value="SEG80481"/>
        <property type="gene ID" value="SAMN04489712_11389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG80481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="18231" checksum="0DFD3AC288468E19" modified="2017-01-18" version="1">MALLELYDAALPEVYGYLLSRCGQRSLAEDLTAETFLAAVEAVRRRPPPALSVAWLVGVARHKLADHWRRAAREERGLRVVGGRDGDCEDPWDERLDALVAREVLAELGPHHRAALTLRYLDGLPVAQVAEHLHRTVHATEALLVRARGAFRDAYARREGRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D791</accession>
    <name>A0A1H6D791_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81277">
        <property type="protein sequence ID" value="SEG81277"/>
        <property type="gene ID" value="SAMN04489712_11414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="27893" checksum="D9D92089D59F9310" modified="2017-01-18" version="1">MRTSEIREAAAALLDAHRSGTPIPPLSMTYPSATIADAYRIQQEQVRFWTEAGDRVRGHKIGLVSAVIQRQMGVHEPDYGHLTASMFHPEHRPIPAGAFLQPRIEPEIAFVLGAPLRGPGVTVDDAGRAVRYLLPALEIVDSRIRDWKITIVDTIADNASSGAAILGSTPIDPAEVDLPSVSCALLRNGTVIETGTGAAVLGTPFNALAWLANAIGALGVSLEPGQVVLSGSITRAIAIAPGDSIMAEFPGIGRVTAMLAEDDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7M4</accession>
    <name>A0A1H6D7M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of protease activity HflC, stomatin/prohibitin superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80853">
        <property type="protein sequence ID" value="SEG80853"/>
        <property type="gene ID" value="SAMN04489712_113164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="89"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="33757" checksum="FA9D5E6513C4D45D" modified="2017-01-18" version="1">MGTTSTPAATTAVTTAANMPEPTISERPARHLNGWWMLLPALVLIIVGATTAAGGAAGIGGSGGLPTAAGIALLVGGCLVATAGLVLMGGLTFVAPNEARVLQLVGASYAGTVRRDGLRWVNPLTERRKISTRIRNHETGPAKVNDLDGNPIEISAVVVWQVEDTARACFAVDDFVEFVAFQTEAAVRHIAGSFPYDAADRLSLRDNADEITARLSEEIGVRVASAGVRIIESRINRLAYAPEIAQAMLRRQQAGAVVAARQRIVEGAVGMVELALAKLEEQDVVELDEERKAAMVSNLLVVLCADRDAQPVVNTGTLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8Q8</accession>
    <name>A0A1H6D8Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized lipoprotein YddW, UPF0748 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81622">
        <property type="protein sequence ID" value="SEG81622"/>
        <property type="gene ID" value="SAMN04489712_11499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GHL10" evidence="3">
        <location>
            <begin position="49"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG81622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="517" mass="56458" checksum="55ABC8DB6223DCFA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DA43</accession>
    <name>A0A1H6DA43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81954">
        <property type="protein sequence ID" value="SEG81954"/>
        <property type="gene ID" value="SAMN04489712_114179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="169" mass="18807" checksum="1AD57639129419A8" modified="2017-01-18" version="1">MTGSSAQGIKTVPHPVSDLAKAEARSRVQRRHDTEHRLAHDIDVWVASASADGVPYLVPLSFDWDGEALLVATPAGSPTGRNLAATRVVRLGLGHTRDVSMIDGEVEVLEIDALPGERGDRFAERTGFDPRASATPYRWFRITPRRIQAWREENELSGRELMRDGRWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAY2</accession>
    <name>A0A1H6DAY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Streptomycin 6-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81885">
        <property type="protein sequence ID" value="SEG81885"/>
        <property type="gene ID" value="SAMN04489712_114166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="310" mass="33713" checksum="A231FB88CEBB6FF0" modified="2017-01-18" version="1">MHPSIRIDVPEALAASHSKYGGASGRAWIAALPRLAADFLNRWTLRLDGPGRHGMASLVLPVTRADGTPAALKLQPVSEEHATEPIGLRAWDGDGAVRLLDHDPDTGTMLLERLDATRPLSSVTDDTTAMRILAELLVRLVAVPAPEGLRRLADIAAAMLDQVPHAVAALGDPADRRLVRTCASAVAELIGEPGDRLLHWDLHYDNILAGRREPWLAIDPKPLAGDPGFDLWPALDSRWEELVATGDVTRALLRRFDLLTEALGLDRQRAAGWTLGRVLQNALWDIEDGETALEPAQVTVATTLLRHRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBA4</accession>
    <name>A0A1H6DBA4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">60 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_114183</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81975">
        <property type="protein sequence ID" value="SEG81975"/>
        <property type="gene ID" value="SAMN04489712_114183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG81975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="197" mass="20578" checksum="A86DB9487F3EE1B9" modified="2017-01-18" version="1">MNQIRTEIDATDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVPGGGVALLQAGAKAFDKLELSGDEATGAGIVRRALEEPIKQIAVNAGLEGGVVVEKVRNLPAGEGLNAATGEYVNMFETGILDPAKVTRSALQNASSIAALFLTTEAVIAEKPEKDKAPAMPGGDAGMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DC46</accession>
    <name>A0A1H6DC46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein, DUF952 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82754">
        <property type="protein sequence ID" value="SEG82754"/>
        <property type="gene ID" value="SAMN04489712_11578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13884" checksum="E89CE2EE600EAF08" modified="2017-01-18" version="1">MKQETRPATVGLPSLRGGEEVKGEIFHIADRTAWDAARAAGGPYEMSTRGRTLADEGFIHCSRSEEQTAGVLHRFYGDVAPEDLVLLVIDPTGLDVRYETADGDTFPHVYGSLPLTAVIDVRSVPGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF19</accession>
    <name>A0A1H6DF19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IstB-like ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83899">
        <property type="protein sequence ID" value="SEG83899"/>
        <property type="gene ID" value="SAMN04489712_11696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="8855" checksum="E6FF045C697B6ABB" modified="2017-01-18" version="1">MELDRHGAELLFQVLTEREEKASAAIASNESFGWTETFIDPRLCAAIVDRLTFGGAIIETGIDSYRLAQSRARAEQHTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGS0</accession>
    <name>A0A1H6DGS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_116115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83973">
        <property type="protein sequence ID" value="SEG83973"/>
        <property type="gene ID" value="SAMN04489712_116115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="197" mass="21298" checksum="77076326E2480D89" modified="2017-01-18" version="1">MLWHALPRFAEGVVAPVAVFYAAFVLLGLNGALVAAVSWVYGGIVWRKVRGQGVPGLLILAALGVTVRAGLAAVTHSPVVYFLQPTLGTLMVSMTFLASVPLNRPLARKVATDMVPMPEAFLRHERVHRFFLRISLLWSLVFAINAAISLWILFNESIGTYLWVRTGLVAALGAVAVAVSVLGFRRCLRHVNAEPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLR3</accession>
    <name>A0A1H6DLR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Long-chain-acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86202">
        <property type="protein sequence ID" value="SEG86202"/>
        <property type="gene ID" value="SAMN04489712_11917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="129"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="241"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG86202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="389" mass="42217" checksum="B65FAB94DD0455E2" modified="2017-01-18" version="1">MPLRPQLDRTVYGDEHRDFGDMVGAFLRNEVAPRVAEFEAAGMVDRDVYRSAGKLGLVGLQIPEEYGGGGQDGFLFNCVLTEQVAYERVTLGSLRVHTDVVTPYVLSLATDEQKRRWLPGMASGELMTSIAMTEPATGSDLAGMRTTLRRDGSDWILNGAKTFITGGAQSDLVLVVARSSSSEDDRRAGLTIVVVEAGMPGFTRGAKLDKLGLKAQDTTELFFDDVRLPAANVLGEEGQAFGYLSSHLAQERLSIAVNSQAQAVAALDLTCAYVRDRKVFGRQLGGFQNTKFVLAEQATQIAAGQALVDQAMARHERRELAPAAAAQVKLFCTELHGRVADACLQMHGGYGYVWEQDICRLYADARVARIYGGTSEVMKGIIARTLELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMV8</accession>
    <name>A0A1H6DMV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_118136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86036">
        <property type="protein sequence ID" value="SEG86036"/>
        <property type="gene ID" value="SAMN04489712_118136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="88"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG86036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="547" mass="58663" checksum="8EE5E15B3EE6BB4E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPK6</accession>
    <name>A0A1H6DPK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3',5'-cyclic AMP phosphodiesterase CpdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87198">
        <property type="protein sequence ID" value="SEG87198"/>
        <property type="gene ID" value="SAMN04489712_12086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="27003" checksum="C21C408485101CFB" modified="2017-01-18" version="1">MLVFAQLSDLHLDGGVARARRAEAVLRHLTSLSAPLDAVLVTGDIADHGLPAEYEQARKALACPYPVLTCPGNHDARAAYRRVLLGEDGGTGPDAPINRVHRVGSPAKAVFALCDSTIPGHDDGRLTDETLHWLDSVLAEEPGVPAFVCFHHPPVVLHAPYVDEIRQFDERRLADVIARHPQVVAVLCGHAHTAAATTFAGRPCLVAPAVASTVRLAWERGDPLDHLAPPAVAFHILDDQGRLTTHHRVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRK9</accession>
    <name>A0A1H6DRK9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87848">
        <property type="protein sequence ID" value="SEG87848"/>
        <property type="gene ID" value="SAMN04489712_12117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG87848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="42015" checksum="A14AE01E6A34E7C3" modified="2017-01-18" version="1">MTALDLAAARAVDAGVVAARIERMADRLAAAGYLTRPQWRQAMRAVPRHLFAPGRAWCVPDGPGDAYGIDADADPARWWEAVYSDAAVIIQVDDGRGDPGTGDGAWTSSLSAPGAVAAFLELLAPRDHDRVLEIGTGPGWTAGLLSERLGAGNVVSIEVDPAVADLAAANLHAAGYEPTLVAGDGADGWADGAPYDAVHVTCGVTTVPYTWVEQTRPGGTIVLPWMPEYIGGYKVRLTVGDGRATGRFHGPASYMMLRSQRGGPLTEPDHGIEEEGTRVDPRAVTGDSYGADIAITAMLPDVAAVEDATGDGRYALVLADTVGTSWARVEHRPGRREHLVRHAGPRPLWDEVTDAYLRWVGWGSPGRDRFGLTVDPHGQVVWRDDPANVITPRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUA9</accession>
    <name>A0A1H6DUA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88871">
        <property type="protein sequence ID" value="SEG88871"/>
        <property type="gene ID" value="SAMN04489712_12297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG88871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="26137" checksum="7C6523601A205EBA" modified="2017-01-18" version="1">MMGQAELVGFAVGVLIALVTAPVGVSGAVFLLPVQLSLLNVPSPAVTPTNLLFNVVAGPGALARHHRQGTLTGPLTRLLIAGTLPGVIVGALIRVFAVPGPTVFRVLVGLLLLPLGLWLCARTLRPVRAHNDPPSTRFITTLALAVGAVGGVYGIGGGSILGPILVGRGMPVAQVAPAALVSTFLTSVVGAATYAALSLTTSGDIAPIWSIGLTCGLGGLIGGYLGARLQPRLPDAALRLMLGLLATALASLYLLQAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVH5</accession>
    <name>A0A1H6DVH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="7" type="ORF">SAMN04489712_12378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89372">
        <property type="protein sequence ID" value="SEG89372"/>
        <property type="gene ID" value="SAMN04489712_12378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG89372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="7374" checksum="8E6EB7B81A22B8CA" modified="2017-01-18" version="1">MPKTKTHSGAKKRFKLTGSGKVTRRRANRNHLLEHKPSKRTRRLDGRVVVADSDAKNIKKLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVI2</accession>
    <name>A0A1H6DVI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88595">
        <property type="protein sequence ID" value="SEG88595"/>
        <property type="gene ID" value="SAMN04489712_12239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="427" mass="48022" checksum="51BA372FC3BDAC14" modified="2017-01-18" version="1">MSETTSERVQEEFTKATSAELQDADIEKDRAILGRDWASRSQEFLSTATPEAIRNFAHGYGDDNPLYCDPEYGRGTRWGGQIAPPIMAAVLNAPLRGERPSKQERGGSYRGIHAFVSGGTWDWYRPIRPGDTLYSFGGLESVEVKRSEFAGRSVVKVHREVKMNGNAEVVGVYRTLVIYTERKKARERGKYAGIEEPSYTDEDLARIDEIYAGERPRGARPRYFEDVAVGEVLPAMVKGPLTTTDMIVFHAGGYGFVPYGLKTGRLAYANRQRIAPFYIKNEYGVPDVAQRVHWDSAWSQAIGNPRAYDYGVLRECWMHHYLTDWIGDDGWVVSQHDEIRKFNYHGDVQFLSGEVTGKYEEGGRCLVDIAFKATNQRGEDTIKGTATVCLPSREHGPALLPEVPADLQRRAVEMMARHGELLREGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWQ6</accession>
    <name>A0A1H6DWQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidylate synthase</fullName>
            <ecNumber evidence="1">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.45" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89629">
        <property type="protein sequence ID" value="SEG89629"/>
        <property type="gene ID" value="SAMN04489712_12411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="4">
        <location>
            <begin position="14"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG89629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="299" mass="33767" checksum="ECC3E6C038DF0555" modified="2017-01-18" version="1">MRYSPYRERTPDGQYRELLRRILETGSPVPTRQGPAAITLMQQTMRFDLSNGFPLITERSIKSFWNKPIGELCAFINGARTLSELEKFGCDWWGPWGTEAKTAKRGLPPGDLGPGSYGAAFHDFSTVEGAEGFDQFRHLVEQLRELPGDRTHFVSPWIPQYLVRGAGKTPKATIAPCHGWVHVRVLDGRLHLHMFQRSGDVPIGVPSNMVQYAALLLMLEHLTGFEAAAYYHTISDAHIYEDQVDAVRTMLEREPRPLPTVRLNDLGRQVTDIHGFRADHFELTDYDPHPAIRSIPVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX97</accession>
    <name>A0A1H6DX97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG89972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89972">
        <property type="protein sequence ID" value="SEG89972"/>
        <property type="gene ID" value="SAMN04489712_1252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="52"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG89972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="313" mass="32648" checksum="AF3ED0EDC65187E5" modified="2017-01-18" version="1">MSNPTPNTPVPDSPSGSPMPASPRSGPRSGAPRLAVRKTYKLFIAGAFPRSESGRSYVVNDAKGAFLAYAAHASRKDARDAVTAARKAFAGWAGRAAYNRGQILYRIAEMLEGRRAQFIDELRAAGLAKTAAAGEVEAAIDRWVWYAGWADKLTTVAGSANPISGPFFNVSTPEPTGVVAVIAPDSPLLGLVSVLAPVIVTGNTCVVIASEPAPLPAITLAEVLATSDLPGGVVNILTGHREELAPILASHMDVNALDLAGTPTDQAGPLQEAAAGNLKRVLPPTGDEWTTDPATTRMTAFLETKTVWHPIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY24</accession>
    <name>A0A1H6DY24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">T/G mismatch-specific endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Vsr family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90208">
        <property type="protein sequence ID" value="SEG90208"/>
        <property type="gene ID" value="SAMN04489712_12569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00221">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004603">
        <property type="entry name" value="DNA_mismatch_endonuc_vsr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03852">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00632">
        <property type="entry name" value="vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG90208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="260" mass="29516" checksum="528726972F95AFEA" modified="2017-01-18" version="1">MSGHWRESRPADMAWRAARGLSRDQRAAEQDQAAGGRERRTVILPDGGRAVASVYLRVPPKTRRIYAYLRWSERGSTVERYVGEVGEASRADNLSLAWSTIQKRQLLVAGSEPLANSRSSKRGESWASSPAVRAVMRGNKSRDTRPEKALRSAVHALGLRYRVGMRPLPEIRRTADLVFTRAKVAVFLDGCYWHGCPEHYRPSKQNKEFWEKKIGGNRARDAETDRLLREAGWETVRVWEHEDPLESAAKIARVVRDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYG1</accession>
    <name>A0A1H6DYG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90179">
        <property type="protein sequence ID" value="SEG90179"/>
        <property type="gene ID" value="SAMN04489712_12561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="124" mass="14046" checksum="6468A8BA6146D3BE" modified="2017-01-18" version="1">MAWDVILLEPVESWFLKLCESDVDTAALIEQAIDRLAEVGPTLGRPLVDTLEHSALRNLKELRPGSRGRSEIRMLFVFDPDRAAIFLVAGDKAGQWSRWYDEAIPLAEARYAEYRATKDKEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYP5</accession>
    <name>A0A1H6DYP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90472">
        <property type="protein sequence ID" value="SEG90472"/>
        <property type="gene ID" value="SAMN04489712_12648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG90472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="26267" checksum="9D03C68FE667D6E7" modified="2017-01-18" version="1">MAQVDGRITGGDGTSSAGAAALEVVGVTAGYGAHTVLRDVSLAVGDGEVVTLLGHNGAGKSTLLRAIAGALDVERGDIRFAGVSQLGRGAARIAQDGIALVPQGRGIFPTLSIGENLRLGAGVARNVTDRTRVTLDFVLELFPALADRLHEDAGTLSGGQQQMVAIGTALMASPKFLLLDEPSTGLAPVLVQTMLAQIRSVHRELGIGVLIVEQNIHEALRISDRAYVLRLGEIVREGPASTLLDAPDIWGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E077</accession>
    <name>A0A1H6E077_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tat (Twin-arginine translocation) pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90769">
        <property type="protein sequence ID" value="SEG90769"/>
        <property type="gene ID" value="SAMN04489712_12733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="281" mass="29857" checksum="22D7161F18351559" modified="2017-01-18" version="1">MDRRAFLTATGLAGAATAPGPLTGVARAAGPADSALVLRALTRLTADTMSGLAVFVLPGPDAYSRAQGTPRREPGAIEAGVPAFLVDALNRYLPFPDQVAVPLMRALVQGAGSLSLPAPREGDAQAGTVRRVDAGLRRLLENDATIPLAPVVALLLNLEAVRVDPLAVGGPFLSPFARLRYARKARVFQLLEGPDPTLVAILDRHLPEPLRGSVSGLLKFLAGALLELTALGSYSEWAVFDPQTRRLRGRPVGWRICGYTPSADGWDEHRGYYQGRKQVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0P6</accession>
    <name>A0A1H6E0P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91170">
        <property type="protein sequence ID" value="SEG91170"/>
        <property type="gene ID" value="SAMN04489712_12853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="49"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="21840" checksum="3ED66D0BDCC1D1A1" modified="2017-01-18" version="1">MADVPREGREGPGEPPVRPGAHDAEVAGTLIEVVPNGAWAVRVLLCATFPAVEEQVRGARRAVRRVLGAHPEFDAGDAELLVSELAGNAVRHSGSRVFTVELACTWSGALRIVLVDEGRGSTTPHLRAGGPSDLGGRGLRLVNELAGRWGVVRERGGRLAVWCELGGGPQPYARPGLRGGRRLARRVRDGDPGFPKVGYGLVAGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1H4</accession>
    <name>A0A1H6E1H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91488">
        <property type="protein sequence ID" value="SEG91488"/>
        <property type="gene ID" value="SAMN04489712_12933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="81" mass="8901" checksum="780D773944196E82" modified="2017-01-18" version="1">MPSSYGYPVEARAASAQAGERTAADEGSPQTCWIMHVGLWLKGCLPPAPPTPREAVKVTFVPVRIETSTWWHSGRYGEKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E286</accession>
    <name>A0A1H6E286_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly-gamma-glutamate synthesis protein (Capsule biosynthesis protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91273">
        <property type="protein sequence ID" value="SEG91273"/>
        <property type="gene ID" value="SAMN04489712_12878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="325" mass="35069" checksum="4282AE8F9CE9C5B4" modified="2017-01-18" version="1">MPITLALAGDTMLGRDVARRLSAVSSRDLFSTAVRNRFTAADLAIVNLECCISTRGEPWRSPGKMFHFRAPPKAAESLSWLGVDCVTLANNHALDYGFEALADTLDHLENAGIEAVGAGLDVEQARAGVILEARGMRVGVLGITDHPADFAAGPHRPGVAYADLGSGVPGWVTERIADLHRRADAVVVTPHWGPNMIAEPLPYVRRAAERFVDAGATLVAGHSAHIFHGVAGPILYDLGDFIDDYAVDDRLRNDLGLLWLVTLDSRGPLEVTAVPLALDYCRTRQAGGNERSWIRDRLTRASAEFGTPVEEHDGVFTLRVAVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2V2</accession>
    <name>A0A1H6E2V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH2:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91960">
        <property type="protein sequence ID" value="SEG91960"/>
        <property type="gene ID" value="SAMN04489712_13144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="312" mass="31335" checksum="447485AF33E94E0E" modified="2017-01-18" version="1">MRAVLVSVPGDEPRVHTLADPVPAAGQVVVDMLYAGVNPIDVWIARGELGSAVPFPHVPGCEGVGTVDDVPVALVAPGLGRGRPGTYAERVVVGAGEFVPLPAGVDPVQAAGAKTAGLTALEVLQTGGLTSEDVVLVLGASGGVGSFAVQLAKNAGARVLAHTASAAKSEAVAELGADRVVTAAAPELLAAAVGDDRPTLVLDGLAGDWTQGAAAAAAEEARIAVFGTSADRRLTLDARTLYGKRLRVQGGNRPKPPADVLREDLAGLLSLMAEGRVRVPVTASLPLGAAAQAHASILARTALGKIVLSVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E456</accession>
    <name>A0A1H6E456_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein YoaK, UPF0700 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92101">
        <property type="protein sequence ID" value="SEG92101"/>
        <property type="gene ID" value="SAMN04489712_13223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="23920" checksum="39412EAAFEE6A66C" modified="2017-01-18" version="1">MTGGGTRDGGQTDGPLPRLFVALAFTTGMIDAVSFLDLGQVFVAAMTGNIIILGLGLAGDGTPLPSALSLMSFAAGAGGGGRAVLSWPGNRHRGLLLAVGIAVQTVLVCGASVLASRYGFAEPWARWPIIVMLAFSLGWGYAIVRGMKVLDLNTTVVTTTLTALFAEPVVPAKQSRRLVSICALLAGALVSGALRRVLFPAAPLWTAVLVLTGCTVITCVAARRSDAERWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E487</accession>
    <name>A0A1H6E487_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92053">
        <property type="protein sequence ID" value="SEG92053"/>
        <property type="gene ID" value="SAMN04489712_1325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7544" checksum="47E5A29739165359" modified="2017-01-18" version="1">MPSPPDNSAEIMELERRNEAYEELHARTAVHELATERIEELSDDAAEVESALHRAGDAAKRLGDRDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5Z2</accession>
    <name>A0A1H6E5Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93198">
        <property type="protein sequence ID" value="SEG93198"/>
        <property type="gene ID" value="SAMN04489712_13742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="26200" checksum="F53FDEF030A65D6D" modified="2017-01-18" version="1">MGSTNPVVSPARPAEPAVRSVSAADRPPTGPRPAVVPPVTDPGPAAVPPADAFGAAERAVAVLLAPPAADVLPLAVVLLAAGLRAVVLAPVVLAAPDFVLVDFLAVVVLDVVDLRAGCLAAVVLPPAARPVVVFLPLEVPLLVSVAPDVPRALATPTTVLVAPTIALPAVVTALVTTPTDVLAVEAVLAATDFICSVAEVSAAGAVVRRLPDVAARVDLLPAVVFVRPPVVLRAVPVFPAAVLFARVAVLRPVRDVVFAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E828</accession>
    <name>A0A1H6E828_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prostaglandin-endoperoxide synthase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93309">
        <property type="protein sequence ID" value="SEG93309"/>
        <property type="gene ID" value="SAMN04489712_13815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="538" mass="61693" checksum="60C8747D16935F6C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E870</accession>
    <name>A0A1H6E870_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93146">
        <property type="protein sequence ID" value="SEG93146"/>
        <property type="gene ID" value="SAMN04489712_13726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="15014" checksum="E35BEB997AA4C813" modified="2017-01-18" version="1">MGRAGAERDVRRLLEASLRLPYTGSEGIGSTEKAFLEVERLAATLTRRHGRLRFLGMLAGIVQSGARELARVSGRSPEAIAAAHTGFCSDDGLREWMAEVMRTPAGAAWSPPPADAAMAPAMALAYLHVTLCLALHGETKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBY3</accession>
    <name>A0A1H6EBY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">SAMN04489712_14713</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="FNVO01000047">
        <property type="protein sequence ID" value="SEG94414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94414">
        <property type="protein sequence ID" value="SEG94414"/>
        <property type="gene ID" value="SAMN04489712_14713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="86"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG94414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="34018" checksum="DDE2FC8191365817" modified="2017-01-18" version="1">MLGERGTHSGVMAVRTRFRPDRGLTVRMVWTVFLLGLLYVLFVAALVALLKSVFWVVVIAGGLLFAQYWFSDKIALAGMGARTVTPQQAPELHGLLDRLCATADMPKPRVAISDSDLPNAFATGRNQENAVVCVTTGLLRRLDTQELEGVLAHELSHVAHRDVAVMTIASFLGVLAGLVTRFAFYSGLFGGRGRNNQQGFPVLLAVLLVSAVVYAVSFLLIRALSRYRELAADRAGALLTGRPSALASALTRVSGDMARIPTRDLRAASAFNALFFAPAIPSRASLAGLLMTHPPLERRVEQLARISREIGEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S112</accession>
    <name>A0A1H5S112_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44180">
        <property type="protein sequence ID" value="SEF44180"/>
        <property type="gene ID" value="SAMN04489712_10133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF44180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12113" checksum="AA6774EC27AB61AD" modified="2017-01-18" version="1">MKFELVEPPEPGPSGAPPEDGQPVKVHALDEGTDDPIAGLVAITHRLTVEVAAESIRVRAATAELAAAVHAGPYALRTFEGVRPPAGFRAGRFGPAARAGEDRRGPGRSADKDGRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S963</accession>
    <name>A0A1H5S963_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47163">
        <property type="protein sequence ID" value="SEF47163"/>
        <property type="gene ID" value="SAMN04489712_101123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42194">
        <property type="entry name" value="PTHR42194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF47163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="297" mass="32474" checksum="A506A30F498C8640" modified="2017-01-18" version="1">MRRRRLRWRLRRLTGDMDEGTRHRDDPPPGLGVGIGWRPEIAGFVAGLPGLRFTEVIAESVHRDHPPSGLTALRDRGVRIVPHGVRLSLGGAEPVAAERVAHLAATAELLRAPLVSEHVAFVRADGMEAGHLLPVPRTRAALDALTDNIRRTCAELPVPLAVEPIAALFDWPDAEYDEADFLTELLERTDALLLLDIANVHANARNRGEDPLVLLDRLPLERVAYCHVAGGRQHEGLYHDTHTDPVPAEVLALVRELAARHRPPGFLLERDGRYPPAADLRAELDAIAGAAGLAVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SG26</accession>
    <name>A0A1H5SG26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase (Penicillin-binding protein 5/6)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_101189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49370">
        <property type="protein sequence ID" value="SEF49370"/>
        <property type="gene ID" value="SAMN04489712_101189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009283976" evidence="9">
        <location>
            <begin position="20"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="32"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF49370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="32374" checksum="DD5CB00BCF22FDE0" modified="2017-01-18" version="1">MPLLGTALLVGTPATMAAAAPASPAPPAGATAAGPSGVQARSALLYEPAKRKIHWHRSGNTKRPIGSITKAMTAVVVLRAGNLDRKITIKQKYIDYAVRHGGSMANLRPGDKLTARQLLRALMLPSGCDAAYALADVYGPGWRGFVKKMNTTARQLNMGRTHYANFDGLPWPTATAGYSTALDQTKLANYAMKRADFRKVVGTRTYSLAAGGGHRSYTWHNTNRLLGSYRGAAGVKTGYTSAAGYSLMFAATRGKRTLVGVVLNSSTTDSTARFTDASKVLNWGFGVRSTEQLVLAPMPPGANVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SGN9</accession>
    <name>A0A1H5SGN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 family transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49610">
        <property type="protein sequence ID" value="SEF49610"/>
        <property type="gene ID" value="SAMN04489712_101197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="26561" checksum="70968B333FAA413F" modified="2017-01-18" version="1">MTALGPAFAAEWIKLRTLRSSHWALSSAFALSVGLGVLAGRSFSTRWESLPADQRSGFDPTAVGFYGVALGQLAVVVFGVLAVGTEYGGHGGGTIRASLAAVPRRGLFYGAKVLAVAAAALPVCLLTAFAAFFAAQAALGPHGTELGGEGALRATLGAAVYLTLMSLFAVGVTTLLRGSARAMAILLPLLFLGSQGLGNAPGLRAVSRYLPDQAGIAMLQTGGRGVLLRDPLGPAAGLAVLLCWTAAALVGGYLVLRRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SYE6</accession>
    <name>A0A1H5SYE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA(Arg) A34 adenosine deaminase TadA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55586">
        <property type="protein sequence ID" value="SEF55586"/>
        <property type="gene ID" value="SAMN04489712_101412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF55586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="162" mass="17498" checksum="D8810B7D1384870B" modified="2017-01-18" version="1">MVDDGELRYLRRCVELAAEALGKGDEPFGSVLVAADGTILAEDHNRVASGDQTRHPEFELARWAAANMTPEQRAEATVYTSGEHCPMCAAAHAWVGLGRIVYACSSEQLVGWLAELGVPAPPVRPLPVQEVAPGVVVEGPVPELAEPVRELHRRFHTGRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TBP1</accession>
    <name>A0A1H5TBP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60206">
        <property type="protein sequence ID" value="SEF60206"/>
        <property type="gene ID" value="SAMN04489712_101557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF60206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="445" mass="45768" checksum="EBA8C22773432D8F" modified="2017-01-18" version="1">MSGVDLVVAGAGGGLAGALRAASHGLSVVVVDVDEHFRRGNNTSMSTAMIPGAGSRWQREAAITDSPDRFVADIMAKTHGQADERLARALASVSAPLVEWLADGVGLPMELVTDFPYPGHSALRCHTIPGRSGRAMLDHLARAASGIDMLVPARLVGIGDGAAVVEYPDGAREEIDCAAVLLATGGFGAAPDLVRRHLPEIADATYHGGEHASGDALRIGAGLGAATAFMDAYQGHAAVALPAGTLVGWATIMHGAVMTDRAGDRFGDETCGYSEYAAKLAARRGDHGWIVLDRRIHDACLPFQDFRDTVESGALHWAADTGELAETMDVEPARLEATLAAAGRAASGTASDPFGRTWWEAPLEPPYAAVRVSPCLFHTQGGLVVDQHARVLREDGTPIAGLYASGGAAMGVSGHGAAGYLAGNGLLPALGLAYLAADHLAGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TEG9</accession>
    <name>A0A1H5TEG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Citrate lyase subunit beta / citryl-CoA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60407">
        <property type="protein sequence ID" value="SEF60407"/>
        <property type="gene ID" value="SAMN04489712_101563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="6">
        <location>
            <begin position="9"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF60407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="30370" checksum="B64CD6664018DD6E" modified="2017-01-18" version="1">MTEPPAPIRSALYVPGDQPGKLAKAPDRGADALIVDLEDAVPPQAKDRAREQVAAWLAGLAAAGGPPQIWVRVNPGLRGLADARAVALPAVTGLCVAKAETPEDLAALDEALGEAPWIALSPILESAAAVLAAPALARCRRVVRLQLGEADLRADLGVEPGPDERELLWARSQVVLASAAAGIGPPLGPVSTDFRDTAALRRSTEALRRLGFYGRACVHPAQLPVVHEVFTPSERELARARDLVERFEKADSGVVLDERGQMVDEAVIRQARRLLATPGTTPGGRPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TEI5</accession>
    <name>A0A1H5TEI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sortase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61226">
        <property type="protein sequence ID" value="SEF61226"/>
        <property type="gene ID" value="SAMN04489712_101588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF61226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="22832" checksum="549F7318E3E675E9" modified="2017-01-18" version="1">MARPKNAEYLAAVVLAVTAAVAWGHGSPEDQRTGQVHDGPRALWHIPDGEAMPASAPVRLEIPRLGVRAPVLPVGRNRDGTVEVPPLHRPRHVGWYRHGPAPGSRGAAVLLGHYDDLRGPAVFYRLGEVRPGDVVRVVRRDRSVAVFAVDATEQVPKEGFPGRRVYGPVRYAGLRLVTCGGTFDHARRSYSDNVVVYAHLTGRERIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TI42</accession>
    <name>A0A1H5TI42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62475">
        <property type="protein sequence ID" value="SEF62475"/>
        <property type="gene ID" value="SAMN04489712_101629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014488">
        <property type="entry name" value="UCP017371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017371">
        <property type="entry name" value="UCP017371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF62475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="132" mass="14413" checksum="6D1E30B5185E515E" modified="2017-01-18" version="1">MAALADYRDTRPRMLTEHFSEYEVRKGGQGAGTVVHWKLAATSKRVRDCLMSVSAPREGTLVEDDANSSMVTTWTVTPSGDGAQVRVETTWNGAGGIGGFFERTFAPRGLQRIYDEQLDRLQAVLAAHPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TIG2</accession>
    <name>A0A1H5TIG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61797">
        <property type="protein sequence ID" value="SEF61797"/>
        <property type="gene ID" value="SAMN04489712_101607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF61797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="28745" checksum="EFDA044EF02451FD" modified="2017-01-18" version="1">MSELDRYGTYRRLKTDWPLPGVLRVTISRPERLNAVDTVGHRELAEIWRDADADERVRAVLVRGEGAAFSAGGDLAMIEEMIADPLVRSRIMREARDLVYNLINCAKPVVSAIQGPAVGAGLAVALLADVSVAGRSARIIDGHTRLGVAAGDHAAIVWPLLCGMAKAKYHLLLCETLTGAEAERIGLVSVCVDDEQVHERALEVAGRLAEGPAEAIRFTKYALNNWLRSAGPAFDASLALEFLGFTGPDVREGVAALRDKRPPKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TLB2</accession>
    <name>A0A1H5TLB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63570">
        <property type="protein sequence ID" value="SEF63570"/>
        <property type="gene ID" value="SAMN04489712_101666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF63570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="15860" checksum="D117952FF1DF8F0D" modified="2017-01-18" version="1">MQKMTEAEWRQFVSEGTRTGKAAVVRADGRPHVTPVWFVLDGDDLVFTTAADGVKGRYLRRDPRISFCVDDEKPPYSFVLMDGEATLSEDVDEMRPWATALGRRYMGADRAEEYGARNAVPGEVLVRVRITHVVAQRDIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TLE9</accession>
    <name>A0A1H5TLE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63048">
        <property type="protein sequence ID" value="SEF63048"/>
        <property type="gene ID" value="SAMN04489712_101648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF63048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="30477" checksum="9C93F94921C1544A" modified="2017-01-18" version="1">MTGQPPGQEPDIEPEIEPEIEIDTTVAHPARVWDYWLGGKDHYPADQALGDQLNETMPEVVIWARADREFLGRAVRYLVAEAGVRQFLDIGTGIPTADNTHEVAQRLAPDSRVVYVDNDPVVLAHARALLTSTPQGATDYIDADLRDPETILKAAERTLNLSRPVAIMLLGILEFLPDEQAYPIVRRLVEAVPSGSHLTVACPASDVNTEAMAEVVQRWNESGATPAVLRSGAGIARFFDGMELLEPGVVPLPKWRPDPGTLFLDREIGFFCAVGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U1G4</accession>
    <name>A0A1H5U1G4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68915">
        <property type="protein sequence ID" value="SEF68915"/>
        <property type="gene ID" value="SAMN04489712_101833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022017">
        <property type="entry name" value="DUF3598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12204">
        <property type="entry name" value="DUF3598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3598" evidence="1">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF68915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="17703" checksum="32D5A26AA4BBE1CC" modified="2017-01-18" version="1">MNVREGMPLLARHEGEWKGTYTYVDPEGNLIDQHASHLSCMFPAEHPDRYVQVNRYRWADGRTEEHTFPGIYDGAGRLHFDTERIKGVTWCLDANTAYLTWRYKAADEELDQRLYELIVLSDDGNDRTRVWQWVENGVCVKRTLINEKRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V567</accession>
    <name>A0A1H5V567_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribose transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82344">
        <property type="protein sequence ID" value="SEF82344"/>
        <property type="gene ID" value="SAMN04489712_102166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF82344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="345" mass="35417" checksum="8FDB490F979AE1AB" modified="2017-01-18" version="1">MKDVSERPPVDDPPGGRAAGGRWPWPAPGLAGAGAAGVRHAGLVAALLLLVLVGVITKPDNFATTGNLVSILALAATIGVITVGMTFVIIGGGIDLSVGAIMALASVWATTVATQSYGPVVMALCAILVGAGAGLVNGLLISYGRMVPFIATLAMLVAARGLAQRMSDRRTQLVRPENDAIMALSTTKVLGLPLLVYIFAAVVAAGWVLLNRTTFGRRTFAVGGNPEAARLAGIDVRRHTLLLYTLSGLCCGIAAIIIMARTTTGSSTHGDLYELDAIAAVIIGGTLLTGGRGTIIGSILGLLIFTVITNLFILNGLDTSDQLIAKGVIIVIAVLLQRRGLRTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VX33</accession>
    <name>A0A1H5VX33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, luciferase family (Includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91127">
        <property type="protein sequence ID" value="SEF91127"/>
        <property type="gene ID" value="SAMN04489712_102474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF91127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="35221" checksum="74C089B08D8057BB" modified="2017-01-18" version="1">MRFGVFLLATRFPGGSDADALVRTAEAAVAAERAGFDDVWVAEHHFMSYGVCPSAATLAGYLLGATSRIHVGTAVSVLSNQHPVALAEQAAMLAAVSGGRFRLGVGRGGPWRDLEVFGTGLDRYEHGFAESLDLLLTWLRSERVGWSGERFAFREVPVVPRVAEPPPVAVACTSPATEALAAAHGLPMLLGMHVGDEEKAAAVARYGAPAAHISTGLAQVADSRREAVRLVTREMPRWLGPGLDGYVPVDNRPRQRRDPHEYTRRLCDLHPVGSPDDCVESLVTTVERTGIRHIVLMVEAAGSRERTLENIARLGEEVLPKARAACPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VZW7</accession>
    <name>A0A1H5VZW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92411">
        <property type="protein sequence ID" value="SEF92411"/>
        <property type="gene ID" value="SAMN04489712_102523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="237"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="253"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF92411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="488" mass="53458" checksum="CA7F89BC72F6119A" modified="2017-01-18" version="1">MSWEFRKVKPGENVAVEAQRDPFAAPKWAPPVWRMPEGLVLLVGLLRLLARLLAFCVRHPIAVGAAAGAGWLGVRYGWHVPALLAVLAGLGLASWAVADRPSFVRWVVRPVRSRWRGWWVYRRHWQPVLVTAGLTKMHRGREYLPTLRTVVAGPTSDRVLVVMLKGQAPDVWERAAANLAHGFGATLVRVRDGDRPGRVWLEFVRIDALASPLPALPLLDAAAVDLRAVPVGRQEDGSPWRLRLLGTHVLIAGATGSGKGSVLWSAVRGVLPLMVAGLVEVWAIDPKRMELSYGRVLFERFGRYSSDPSGGMVKLLEEAASDMNARAEEFAGLTRSFVPTVEHPFRLIIVDELAFLTAYSPERDLRKRAESALAVLTTQGRSVGYCVIGAQQDARKEVNNLRNLFPDRIALRLDEDEQVDMVLGDGARDRGALADQISSVPEIGAGVGFVRLESCPDPVRVRAAYVSDADIRAMVAWATGGVDAREVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W1Q0</accession>
    <name>A0A1H5W1Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR C-terminal helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93208">
        <property type="protein sequence ID" value="SEF93208"/>
        <property type="gene ID" value="SAMN04489712_102551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF93208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="427" mass="47616" checksum="BCEE3694D7E95928" modified="2017-01-18" version="1">MTTPEQRTALPPWTGVPCEIADLCRPYLADVAEEMIEEIQRGVPEYARPLDEEYVRMVRLAVEGALGQFVDLIGDSGASWEPVAAVYREIGWAEAREGRSLDALQTALRLGARVAWRRLAAEAEKLNVSRRTLGRLAEAIFAFLDEIAAAATQGYHKARAQVAGELEHRRRRLLDLLLAEPPAAPQAIVDLARVAQWRLPQTVAAVALAERGPDRYAHPSLPPDVLADVNRREPCLVVPDPDGPGRPRMLENALRDWVAAVGPTVRVEETAKSLRWAREGLALARRGVLPADRPVRCVEHMPTLVMFKDEDLIRIVGERRLAPLQKVRARHRERLARTLLACLQSGFNATEVATRLHVHPQTVRYRLHQLEELFGDELYDPDIRLEFEMVLHVWLFQAQEADAPATVISLEGGRQSALAPTAAATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W6I9</accession>
    <name>A0A1H5W6I9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_102604</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94958">
        <property type="protein sequence ID" value="SEF94958"/>
        <property type="gene ID" value="SAMN04489712_102604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="13">
        <location>
            <begin position="56"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="12">
        <location>
            <begin position="207"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEF94958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="301" mass="33378" checksum="DFB7EB0319591CE8" modified="2017-01-18" version="1">MRAQFVLQEIWIGLRRNLTMTISLVITVAIAMALLGTGLLIKLQVDSSKSYWHDRIEVSIFLCAKTSSNANCNKTDVTEQQKQEIQNDLKGLSVVKEVKYESKEEAFERFKESFSNSPGFVNSTKVGDIPDSFRVRLKDPEKFEEVTKLLANRAGVDQVVNEKEILDRFFKILNGLQWAAIMIAVIQVVAAVLLVANTVRLSAFNRRRETGIMRLVGASNLYIQLPFILEGAIAGLIGGGFAAILLVGSKVVLIDQLQESLQFTSQLGWGSVFGVIVFSICVGVLLCAAASFLSLRRYLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WEX8</accession>
    <name>A0A1H5WEX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylglycerophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97920">
        <property type="protein sequence ID" value="SEF97920"/>
        <property type="gene ID" value="SAMN04489712_102694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF97920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="36330" checksum="8E18140926B95C54" modified="2017-01-18" version="1">MAFTLEDVRSRTYKARDAWWTVLLVDPLASRLVKFTANRTGVTPNQLTTGALFLGLGAAACFATAETTWLLVGALLYHFSFVLDCMDGKVARLKGTGSVFGAWLDYIFDRVRVLACAIALMGGQYAATGNVAFVWTALAVVFLDMLRYLDALEIYKVRSQMRSRLVKTQQRVAELELATRTVPDEVDSMLESATGKVVEESVQPHVLMQQGFNQRFPWYARVRNGLMRGRIRPHLISGIEFQMAVFIVAPLLAVLTSHAIIWTTALAGAGLLFFELVIIYKFYLSSRDFARISTELEAKITEYEALLPPEPEQAEQPIRPAVGHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X0W7</accession>
    <name>A0A1H5X0W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase alpha (Molybdopterin) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05020">
        <property type="protein sequence ID" value="SEG05020"/>
        <property type="gene ID" value="SAMN04489712_10330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="5">
        <location>
            <begin position="120"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="6">
        <location>
            <begin position="640"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG05020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="755" mass="82247" checksum="43E9F9A3E7E66CE0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X1S3</accession>
    <name>A0A1H5X1S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05493">
        <property type="protein sequence ID" value="SEG05493"/>
        <property type="gene ID" value="SAMN04489712_10346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG05493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="33434" checksum="87DC13970D593E9D" modified="2017-01-18" version="1">MLLAMEWFERVARMRRWTRGGERDPNRVLLLLLALGELHRRGYAPLRYRDVEEPLGELLAEFGPAKPASPGYAFHQLAADGLWEVLTHQGVGSPGPDASTLRAYDAAGRLAPRFAKELMADAAVFTQIVRLLLQLNFEPGLHDDLRTAVGLPPEPAVPASVAAHVEGLLPRARPDVLLRQKVLVAYDCRCAFCGFEGWMGNSVVGLDAARLRWGAFDGYDDLSNALCLCTLHHRLLDRGVLSLTRSGAILVSRHFVGTTESARTLVDSLVGRRVAAPRAGFPGPHRTNVDWHARQVFRGPARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X3V8</accession>
    <name>A0A1H5X3V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipid kinase, YegS/Rv2252/BmrU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06067">
        <property type="protein sequence ID" value="SEG06067"/>
        <property type="gene ID" value="SAMN04489712_10365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG06067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="310" mass="33716" checksum="E3A508D157B5AD57" modified="2017-01-18" version="1">MRSKQDLEAAIRGQGRAALVVNARSRRGRRLFVKARRLLTEAGLTFAEVHPVTDPARLPDVLGEVLDRRPELVVVGGGDGTIAEAVSHLAQRDVALGVLPLGTTNNFARSLELPVNLAGAVRVLREGKVADVDVGFVAGKVFANMVSIGLSVAVAEQVPHELKRRIGRAAYGVTAARLMLRHRPFKATVEVNGKTYEMVTHQLNIANGSHHSGRLFAADASPDDRLLNVYRFGDRSRLRLAADTVAHMLAGPRRRLADDMFLNTSREVRVSTDPPLDIDVDGEIRGRTPVTVGLLPNALRVMVPQTFEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X799</accession>
    <name>A0A1H5X799_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07166">
        <property type="protein sequence ID" value="SEG07166"/>
        <property type="gene ID" value="SAMN04489712_103103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="204"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG07166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="892" mass="96776" checksum="B80E50E7882552B5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X7J2</accession>
    <name>A0A1H5X7J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Benzoylformate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07719">
        <property type="protein sequence ID" value="SEG07719"/>
        <property type="gene ID" value="SAMN04489712_103124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="188"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="380"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG07719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="532" mass="57006" checksum="0E36529A2D7EB2B1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XEL9</accession>
    <name>A0A1H5XEL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chlorite dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09646">
        <property type="protein sequence ID" value="SEG09646"/>
        <property type="gene ID" value="SAMN04489712_103200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG09646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="27386" checksum="44B75AF2083A5A75" modified="2017-01-18" version="1">MTTDNAGRPVTRGAKARDLNQVIRYTMWSVFRVARPVERADEVAGEVEDLLVQATGKDVTTRGLYDVSGFRADADFMFWWHAPSSDDLQEVYGRFRRTALGRSCEPVWSQMALHRPAEFNKSHVPAFLAEEEARAYVCVYPFVRSYEWYLLPDTERRAMLAEHGQMARGYPDVRANTVSSFALGDYEWILAFEADELHRIVDLMRHLRGSEARRHVREEVPFYTGRRKPVAELVAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XH38</accession>
    <name>A0A1H5XH38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10785">
        <property type="protein sequence ID" value="SEG10785"/>
        <property type="gene ID" value="SAMN04489712_103241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG10785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="439" mass="45307" checksum="C8490B7B094E1DD1" modified="2017-01-18" version="1">MSAPAGLARFGWIWLAELISVIGSSLTAFVLSVWVYEQTGSETRFAVTMLCSTLPGILAGPVAGSVADRFDRRRVLIAADCGAALCTVLLAVLVSAGELAVWHVYAVTAVTAVCGTFHLTVHQALTPALIPRRHLGRANGLMQTAWGLQIAAPVVAGALLVTVGVRGVLLIDLATFAVATVTVLLVRLPRSATRPDGAAERPAPVADLAFGLTWLRRRRGLWHLLLVFAAFNFLFGVAGVLIRPLILSFSSPATLGALVFAGGCGIFTGSLVMGAWGGPRRRVRGICLFMALGGGALALHAPRPSVALIAVAAPTFLFTLPVVNGTVMTILQSATDPAAMGRVLAAARTLGQCAMPLAYMTAGPLAEHVTEPLMSPGGPGAGLGPLVGTGPGRGIALLFLVCGALMIALAVVARALPSLRDLEARPDPGHRTDPVVTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XQ56</accession>
    <name>A0A1H5XQ56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen debranching enzyme (Alpha-1,6-glucosidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13567">
        <property type="protein sequence ID" value="SEG13567"/>
        <property type="gene ID" value="SAMN04489712_103345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG13567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="666" mass="70354" checksum="C8722E76885934EE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YHS8</accession>
    <name>A0A1H5YHS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23651">
        <property type="protein sequence ID" value="SEG23651"/>
        <property type="gene ID" value="SAMN04489712_10422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG23651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="29765" checksum="2BEE634F003A9826" modified="2017-01-18" version="1">MNVSTAWFTGLLDDAAVFPPGLMPLPDAVRAHARHTASPYAALVGPLVIAAPALPKLADLLITPPSGRLDVAVTFPDGPGRLVPVLAAAAALPVRVCAVEVAVPSGMEPSAFLAELDRAQAAVAGAEVFVEIPRDGRRPELIAACATTGRRAKFRTGGVTADLYPDEAELAAAVCAAVRADVPFKATAGLHHAVRNTDPGTGFEQHGFLNLLLAVEAALDGGGEADLVGVLAERDGAKLAARLEDRDARAEAVRARFLSFGTCSITEPLAELAALGLVPASFTGHRGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YIH1</accession>
    <name>A0A1H5YIH1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23858">
        <property type="protein sequence ID" value="SEG23858"/>
        <property type="gene ID" value="SAMN04489712_10432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009029578" description="Carboxylic ester hydrolase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG23858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="529" mass="55830" checksum="A9B2AC7654020C97" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YVG3</accession>
    <name>A0A1H5YVG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27435">
        <property type="protein sequence ID" value="SEG27435"/>
        <property type="gene ID" value="SAMN04489712_104178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="28005" checksum="9D463035856A2565" modified="2017-01-18" version="1">MVRVLSRYVRAPDLETSRPAASTRESTMADHWPPTRPWPTTGQEYGQLVVIEPTPPDGWRSNKVTMYLREASYKVMQSAFDGAGIGWQSCLVQARGNGALVLVPAQTPPQASAEPLITGLAAGIRAHNRLHNESAWLRMRMAVHMGIVCFDPAGPAGRAVQLAGALVDSAEFAGACADNCAELGFIASDQVYAEVLREPGLLIEPEMYRPIKLVAQGERILAWTYFRPSPPRPGVTRPYPVKEGVGGDARGWDADEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z5U6</accession>
    <name>A0A1H5Z5U6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ORF">SAMN04489712_104384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31909">
        <property type="protein sequence ID" value="SEG31909"/>
        <property type="gene ID" value="SAMN04489712_104384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="62"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG31909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13620" checksum="F93E795824E8E33E" modified="2017-01-18" version="1">MAKLSNDELLDAFKEMTLLELSEFVKQFEEVFDVKAAAPVAAAVGPVGPAAPAEEAEVKDEFDVILEAAGDKKIQVIKEVRALTSLGLKEAKDLVDGAPKPLLEKVNKETADKAKEALEKAGATVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z6W3</accession>
    <name>A0A1H5Z6W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31347">
        <property type="protein sequence ID" value="SEG31347"/>
        <property type="gene ID" value="SAMN04489712_104353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG31347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="26626" checksum="7E3A24DA21B5D98E" modified="2017-01-18" version="1">MMRRVGAAVADSGPVLILAGIAAAGSFTHIRDTAAEHGQGGWMAWAVAVCIDLTCVMAARERQRDKRTGRQTARLSWPTLVLVGGILLSLAANLAQAEPSVWGWLAAGTPAVAFLVAVSMLERRASAPRPEPSAVPSPDPLPVPPSFGRPAEPSSVPAVEDEPRPQLPAGQGEQTEISVTTADPAPRPADAVPGPAAPLLDFARRVAAEHEDKHGCPITRDALRARLGVSNQLASDLLRQVRADSKGLHAEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZF19</accession>
    <name>A0A1H5ZF19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34892">
        <property type="protein sequence ID" value="SEG34892"/>
        <property type="gene ID" value="SAMN04489712_104521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="17789" checksum="36456A0DC38F938E" modified="2017-01-18" version="1">MSKSTGNGRATSLFLVLLWLALGVTPILSDVTDLRLAFGLIGEPGRVAVTGCTDLGEGRYDCRGVFVPDDPQGRTVRNLKLPPESDAGETFEARLQPDGERAHPTGTKGQLNALALPFLGFAMLVPLPWLIAYMFWGRSPGRASWWVMGVLAGLGCLGCLAGLIAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZGZ1</accession>
    <name>A0A1H5ZGZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Adenosine deaminase</fullName>
            <ecNumber evidence="1 3">3.5.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 3">Adenosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">add</name>
        <name evidence="5" type="ORF">SAMN04489712_104558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:28190"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="1 3"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35729">
        <property type="protein sequence ID" value="SEG35729"/>
        <property type="gene ID" value="SAMN04489712_104558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046936">
        <property type="term" value="F:2'-deoxyadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00540">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028893">
        <property type="entry name" value="A_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A_deaminase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG35729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="349" mass="38524" checksum="79D96D1C924EECEE" modified="2017-01-18" version="1">MLLHDHLDGGLRPETIVELARAGGYDGLPATDAEELRTWFTEASDSGSLERYLETFQHTVGVMQSQEALRRVAYECAEDLAADGVVYAEVRYAPEQHTRTGLSMEQVVEAVLAGFEEGGRDHGIRVGTLLTAMRHQARSMEIAELAVRYRDVGVVGFDIAGAEAGYPPTRHLDAFEYLQRENAHFTIHAGEAFGLPSIWQAIQWCGADRLGHGVRIVDDITGRDTPSPTLGRLAAYVRDKRIPLEMCPTSNVQTGAAKSIAEHPIGLLRRLSFRVTVNTDNRLMSGTGLAAEFAKLVDAFGYDWDDLQWFTVNAMKSAFIGFDERLELINGVIKPGFAQLKWTGSRTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZJQ9</accession>
    <name>A0A1H5ZJQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35877">
        <property type="protein sequence ID" value="SEG35877"/>
        <property type="gene ID" value="SAMN04489712_104565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035197">
        <property type="entry name" value="DUF5313"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17240">
        <property type="entry name" value="DUF5313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG35877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="15241" checksum="B7F0984F0373DE23" modified="2017-01-18" version="1">MLRAEWTDVPRPGVLRTGASRAGASWAGPRVRGRLPGDPGPWQRVRYALGFRLPPANHDWVRHDLTDAGWRGRLMARHLAVMLPICMLLALLPGEWWMHLTVPLLALLASSLTVVVSADDLRNARLRQHGLPPAGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1G7</accession>
    <name>A0A1H6A1G7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42281">
        <property type="protein sequence ID" value="SEG42281"/>
        <property type="gene ID" value="SAMN04489712_105128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG42281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="29065" checksum="5BD7EBE6D1B43051" modified="2017-01-18" version="1">MDSEDDQRTYRQGPAMLRGKAIPHSTTDQRLLDSRGPVDWLHADPWRVLRIQAEFVEGFGLLAELGKAVSVFGSARTDPDSEEYRLGVEIGTRLVEAGYAVITGGGPGIMEAGNLGAVKAGGVSVGLGIELPFEQRMNDHVDIGLEFRYFFVRKTMFVKYSQAFVVLPGGFGTMDELFEAITLVQTGKITRFPIVLVGTAFWGGLLEWIKNVMLPAGKIHPSDLELVHLTDDPAEVVRVIQEAHAEAQRRLEEEAAVRAAADEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A226</accession>
    <name>A0A1H6A226_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-related amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42789">
        <property type="protein sequence ID" value="SEG42789"/>
        <property type="gene ID" value="SAMN04489712_105160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG42789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="198" mass="21409" checksum="2A0E2F6E78D83B60" modified="2017-01-18" version="1">MRRAVIVIDVQESFRRQPIWEATSNPAVVRQVRRLVEHARGEGDLVVWVLHAEAGSGTVFDPALGFVRLMDGLAAGEGEPVLTKTAHNAFTTTNLQQILTARGVREVVVCGIRTEQCCETTARLASDLGFEVTFVTDATATTPIAHRDAPGGRTVAEILADPRTLGTDEIITRTEYALAGRFATIRTVEEVTGVLVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A574</accession>
    <name>A0A1H6A574_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43205">
        <property type="protein sequence ID" value="SEG43205"/>
        <property type="gene ID" value="SAMN04489712_105184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG43205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="411" mass="43467" checksum="80DCE43357C403AA" modified="2017-01-18" version="1">MLAGRYRDSAGGDCGSVSVSWVSLVVLAATVVVALTSAGLPGAVRDAAESALCPLKRDVSCETAAGRVQPVDAPGRDDGTSPPPAGAQDPAHPRDLKDRPVMRPFEGPIISREDYDEPWKCGWFQIGCDVAQGTGLGLVDMVKDGLEGLALVACSTYACGPDNFDDSWSTWKAIADDPWGSVKTGVEEATKEIVHDWQTGHEGRAVTRAIPSILGSIFGGKGVGKLRALGDGSDRGDPVQAQPRDGPDDPAAAPVAPDIPQSEARGALTNLGRYAGLRRWMRRASGGLNLDDYAPGSGFSGVYDPESGTFLARPSGGTVRRDGQRTFTVPRRGGHGMLSEQLRRATKGDPKKHVGFTILIGKDGALRVEWFSRGVNGRNPSFRGSHVPEHLRESILDAIRETTGRVVEGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A846</accession>
    <name>A0A1H6A846_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ERF superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44344">
        <property type="protein sequence ID" value="SEG44344"/>
        <property type="gene ID" value="SAMN04489712_105247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007499">
        <property type="entry name" value="ERF_bacteria_virus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04404">
        <property type="entry name" value="ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="29810" checksum="84E10D97A9462299" modified="2017-01-18" version="1">MTSTPTPSLAAALAKVQAELPKLERDRTVEVTQKNGGTYSYSYVTLARLSEVVLPLLAKHGLSFAAMPGLGADGKMAVRYTLLHESGEALTGEFPISGEGGIQMIGGRITYARRYCLAAVVGVAADEDDESRLADDGAPRAVQRAGQRPRRQASTPKPGEGAATVQRAASRPQASLPPLPGEEPPPPAAPPVGDDQDNGEPVTKPQLAKIGILFQRVGWTERADKLRASSTIVGRPIASSTELTKKQASTLIDALEMVAADDDPADRLTALLEEIRRQEGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AD54</accession>
    <name>A0A1H6AD54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="5">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cysC</name>
        <name evidence="8" type="ORF">SAMN04489712_105375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46648">
        <property type="protein sequence ID" value="SEG46648"/>
        <property type="gene ID" value="SAMN04489712_105375"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="7">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="6">
        <location>
            <begin position="143"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="323"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG46648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="493" mass="53145" checksum="8FB6E40D9C2F8F40" modified="2017-01-18" version="1">MTAEAGLPDTLRDLPAWTPDPVELADLELLLTGAYHPLTGFLGSFDAAMVIAGGRLADGTPWPVPVTLAVPKELTVHERLVLQDPEGVPLAVLRVAEAWQDPTSSRWCLAGPLEPLRAPAHGPFHRLRRRPEEIAGGLPDGPVLAVATREPLHRKQLGQLRQLTDKLGANVLMLPLLGGDHDEALVRALLAVRRDLPEGARLVPVPLPPRGDGDARRDLLLRSHVAAAYGATHIMGEQEAEGTAIPVVVPEPWAYDADVEVWRPVARIEPDHVQAELTPAELAELLDRGEPIPEWFTPPAVAAELAVARPPKLRRGLTVFFTGLSGSGKSTVARGLADALVERGGRTVTLLDGDVVRRLLSAGLTFSRADRDLNIRRIGYVAAEITRHGGVAICAPIAPYAATRAEVRRMVTAAGDFVLVHVATPLEECERRDRKGLYAKARAGLIPEFTGISDPYEEPDDADLVLDTSRLSPEEAVGRVLDLLVAGGWVRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AE27</accession>
    <name>A0A1H6AE27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46424">
        <property type="protein sequence ID" value="SEG46424"/>
        <property type="gene ID" value="SAMN04489712_105363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG46424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="363" mass="37509" checksum="C9D5FB71AAD602DB" modified="2017-01-18" version="1">MKITAAVLRAPHEPLALEETELEGPRPDEVLVRLVAAGVCHTDLVTAAGHDPAAPPLVLGHEGAGVVEAVGADVEAVQPGDHVVLSYGWCGLCAKCGQGRMAYCDSFLELNHHGTRPDGSTAMSRDGEPIRSHFFGQSSWAAYSLTTERNVVRVASDLPLEHLAPLGCGVQTGAGAVLNALRPRKGSSLAVFGAGAVGLSAVMAARIAGCEPIVAVDPDPHRRALAEALGATAVVDPTAGPPAEAVVELTGGVDHAVECSGLPFVVQAAVASLATPGMCVTVGFQGRANPVRLDQTMLVMGRGIRGSVGGDAIPQRFIPRLIEHHRAGELPVERLVRTFSFADVNEAMAAARDGAAVKPVLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B0S1</accession>
    <name>A0A1H6B0S1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_106122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53867">
        <property type="protein sequence ID" value="SEG53867"/>
        <property type="gene ID" value="SAMN04489712_106122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG53867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="16154" checksum="BB0DFD0F3D2E6CFC" modified="2017-01-18" version="1">MKVFNGISELEQAVGTHLGYSDWHTVTQEQIDLFADATGDHQWIHVDAEKAAQGPFGATIAHGYLTLSLLPKLVHQVYRVDGLKMGINYGCDKVRFPSPVPVGSRLRAGVELLELTTGSAGTRAKVRVTVEREGGDKPACVAESLSLLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3X0</accession>
    <name>A0A1H6B3X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55528">
        <property type="protein sequence ID" value="SEG55528"/>
        <property type="gene ID" value="SAMN04489712_106238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="198" mass="22400" checksum="F1D2B050540BC909" modified="2017-01-18" version="1">MVPSGGDAGTFLRSHREPPRWEYRDLLIRRYTAADHAAVMDLHRQGLAQVGLRPGDGVYYEHDLFQIEDVYLRRGGEFVVGERHGELVAMGGLRRADIIPTGVTRAHGGYAVGLPPRTDTAEMVRLRVHARAWRRGYGSAIVRALEERAAELGYRTLHCDTTDRQVAAMELYRGFGWRETRREVIGGLVNVYFEKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5U9</accession>
    <name>A0A1H6B5U9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56209">
        <property type="protein sequence ID" value="SEG56209"/>
        <property type="gene ID" value="SAMN04489712_106294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG56209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="14807" checksum="DCC0A875188168EC" modified="2017-01-18" version="1">MDRVVLDTDVASLSLKRRVPSPVMTRLIGKQPCITFITLGELTQWAELRQWGRRNREALGHWLNGVIVLPYTEDVAITWGHISAAAIRRGRPRPANDSWIAACALAYGLPLATLNAKDFEDFATHEGLTLITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6M1</accession>
    <name>A0A1H6B6M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56260">
        <property type="protein sequence ID" value="SEG56260"/>
        <property type="gene ID" value="SAMN04489712_106299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024031">
        <property type="entry name" value="MSMEG_5819/OxyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04023">
        <property type="entry name" value="PPOX_MSMEG_5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="146" mass="16145" checksum="C9D89ACDFC6F7DB1" modified="2017-01-18" version="1">MTFTEAELTYLVEHPLGRLATIGPDGAPQIHPVAFWVNADAGTLDIGGPALTRSQKFRNVQADPRVSFIVDGESDEPNPIGQRGCGIEIRGRVEIVPLDPPLMPVFDNETLRIHPRRIIAWNIDEFGPASPERLPHMQGYNSRNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BDE5</accession>
    <name>A0A1H6BDE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58690">
        <property type="protein sequence ID" value="SEG58690"/>
        <property type="gene ID" value="SAMN04489712_10712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG58690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="199" mass="21909" checksum="F5AEE8C242967856" modified="2017-01-18" version="1">MGEVMGEIVLLRHGETEWSRDRRHTGRTDLPLTGHGEEQARALGPLVARRDVARTFGSPALRARRTAELAGLAVDEVDPDLWEWDYGGYEGLTSADIRRERPGWYLWADGVIPGDAEHPGESVERVGERCDAVLARVRPWLERGDVAVVAHGHVLRILTARWLGLEPAAGRLFALHTGTLSALGTEHGHPVITSWNVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BEP2</accession>
    <name>A0A1H6BEP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, LytR/AlgR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59243">
        <property type="protein sequence ID" value="SEG59243"/>
        <property type="gene ID" value="SAMN04489712_10756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="4">
        <location>
            <begin position="165"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG59243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="28760" checksum="17523515B588865F" modified="2017-01-18" version="1">MAGLRVLAVDDEAPALDDLAFWLRADPRIEEVAVARDGAAALRQVDRALAERRPIDAVFLDIRMPGLDGVVLGRLLAQFARPPRIVYVTAYDDHAVDAFEIKAADYLLKPVRPERLAEAIRRVSGPGERAAAEPGSAGSEPGAVPPPSPDPELVPVELAGVTRFVAPADVWYVEAHGDYARLHTPSGGHLVRIPLAALEERWRGAGFVRVHRSHLVALRHIEELRLDSGRCTVRVGGTELPVSRRHTRELRDLLVRNARRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BG26</accession>
    <name>A0A1H6BG26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59196">
        <property type="protein sequence ID" value="SEG59196"/>
        <property type="gene ID" value="SAMN04489712_10753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="124" mass="13495" checksum="78D63224C058EC16" modified="2017-01-18" version="1">MEQDAAHDRAVDAFLAAANTGDPQERDRLLSRALTADVVFWGPLGRGVGRKAVAEFITEVVRSHPSGPCRMVRTTRVDAPDEWARFGWRYEDAAGRVLLSGTDVVHVTADGDIDEMIVFAGALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKH4</accession>
    <name>A0A1H6BKH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61221">
        <property type="protein sequence ID" value="SEG61221"/>
        <property type="gene ID" value="SAMN04489712_107195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG61221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="25933" checksum="6CFA41BD7D9A5334" modified="2017-01-18" version="1">MRTSGRPMCRPPGLRSEPGRLPGRPNGQLRHGTLTPHGKSARPHKQTTNQPTRRTLRTPARPSRPQKQESSPLACGTPGPPGKSPRPQAQSSSRPRRGKLSRPGHPQGQGSSSPTSGMLRPPGWAARPQKQAGSRPVRRGLRALGGLGRPQERASIPLGHGTPKPRGRLVPPQMQVGSRPMYRTSRLRSGLGRPPGRTSGRLLPKAPRACGKPSRPQGWGSRRPRRGMLRPRGRPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPI7</accession>
    <name>A0A1H6BPI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62594">
        <property type="protein sequence ID" value="SEG62594"/>
        <property type="gene ID" value="SAMN04489712_107307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG62594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="53" mass="5670" checksum="3E53DB8FAC2C00DD" modified="2017-01-18" version="1">MVQIAHGGVALPRDRDLAVREKTQVPTLGLSTVRWFSPSVSTGSGSTNNSHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BU58</accession>
    <name>A0A1H6BU58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid Dehalogenase Superfamily Class (Subfamily) IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64261">
        <property type="protein sequence ID" value="SEG64261"/>
        <property type="gene ID" value="SAMN04489712_1088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041065">
        <property type="entry name" value="GNAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18407">
        <property type="entry name" value="GNAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GNAT_like" evidence="1">
        <location>
            <begin position="281"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="334" mass="34423" checksum="950FF08F6AC7FB18" modified="2017-01-18" version="1">MRECERPLSEAYDVALLDLDGVVYVGHRPVPGAAEALAKARAAGQRLAFVTNNASRTPSAVAALLTRVGVPATAQDVVTSAQAAARLLAERLPRGSRVLVVGGSGLRQALYAQGLVPVSTAAERPAAVVQGYDPNLSYGLIAQGAQAVARGALFVGSNGDLTIPGGDGPPAPGNGSLMQVIRAATGVEPVVTGKPERPLHQESIIRTGAERPLVVGDRLDTDIEGAHNGGADSLLVFTGVTDPLTALTAGPRHRPSYLAADLGGLLVPHPPVRRDGQGWHCRGWTARWTGAKIELTGEGDPYDGLRALCAAAWRTDEPVAEPAVAAALARLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BV87</accession>
    <name>A0A1H6BV87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_10840</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64624">
        <property type="protein sequence ID" value="SEG64624"/>
        <property type="gene ID" value="SAMN04489712_10840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="172"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="297"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG64624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="383" mass="42397" checksum="5470612530B8F362" modified="2017-01-18" version="1">MRLRYNFRIHPTAGQRQALARAFGCARVVFNDGLRMRQEARVQGLPYVSDAELSKRVITQAKKTPDRAWLGEVSAVVLQQALADLNAAYRNFFASVTGKRKGPQVAPPKFRSRKDRRQAIRFTKNARFQVTAGGKLRLPKIGDIPVRWSRDLPSDPSSVTVIKDAAGRYFASFVVEVGDEPLPETASEVGIDLGLTHFAVLSDGRKIDNPRFLRRAERRLKKAQQALSRKEKGSNNRKKAVVRVARAHVRVADARRDFAHKLSTRIICENQAVVVEDLSVKGLARTKLAKSVHDAGWGRFTAMLAYKAARHGRALVRIDRWFPSSKLCSTCGAVAESMPLNVRTWECACGAVHDRDVNAAINILAAGRAERLNACGGTVRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZH0</accession>
    <name>A0A1H6BZH0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65835">
        <property type="protein sequence ID" value="SEG65835"/>
        <property type="gene ID" value="SAMN04489712_108140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG65835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="17579" checksum="FCF6D2E193F738C5" modified="2017-01-18" version="1">MKVIVLADTHAPRRWRSCPPAVAALLRGADLILHAGDVCTAAVLDELSAYAPVRAVLGNNDSPDVAAWGAPETVDLDLAGLRVSMIHDSGPARGRLGRMRRRFPDADLVVFGHSHIPMDERGEDLRIFNPGSPTDRRRQPHGTVGVLHIEEGGLLHAEIVPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C6Q1</accession>
    <name>A0A1H6C6Q1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68588">
        <property type="protein sequence ID" value="SEG68588"/>
        <property type="gene ID" value="SAMN04489712_1094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="134" mass="15164" checksum="AE4DFE06C8F5660E" modified="2017-01-18" version="1">MTTDDRERIETLIRRWAAAVHAGDMAGVLADHADDIVMFDVPPPQEGIRGIDAYRDAWPPFFRWQAQGALFEITELDVTAGRDTAFAHALLRCGTPQDLERDPGNRLRLTIGLCKRNGRWTVTHEHHSFPFNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7J8</accession>
    <name>A0A1H6C7J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68883">
        <property type="protein sequence ID" value="SEG68883"/>
        <property type="gene ID" value="SAMN04489712_10928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="17614" checksum="7C61B44592E73E67" modified="2017-01-18" version="1">MNGQRVLVAGIGNVFLGDDGFGVEVVRRIDRAELPPCVDVADYGIRGVHLAYELLDRRHHTLIMIDAVPLDGPPGTLAVLEADPEDGPGLPVLNGHGMHPQAVLHLLHTLGGEVDRVLVVGCRPADTAERMGLSEPVAAVVDDAARLAVELARKAALAGTEAEYARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CB41</accession>
    <name>A0A1H6CB41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70073">
        <property type="protein sequence ID" value="SEG70073"/>
        <property type="gene ID" value="SAMN04489712_109139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="46" mass="4898" checksum="21F94D6D47C98ED3" modified="2017-01-18" version="1">MAYAAVFSGSIFALEDEASEVLAWEPQFIPAKSVQLITALARNGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CE43</accession>
    <name>A0A1H6CE43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71103">
        <property type="protein sequence ID" value="SEG71103"/>
        <property type="gene ID" value="SAMN04489712_109241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG71103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="424" mass="47842" checksum="88BE78993129A138" modified="2017-01-18" version="1">MRPADVHIDDLAEPRFSAEAQELVTVMAAMAPACPLEPEALMAAAVQQTEATGRRLEDFGDEAFREPLEILCRSLREEAGLADHGKVVWHVQMVAQLTQRLRLQDLLTRHPEIHDVQIERPIIIAGLPRTGTTHLHNLLSADPALRPLPYWEACEPVPPPGEEGTIEPRVERVAGSLHMVHTTLPYLKRMFDLTPTYSHEEGGLLALTFASTHLEIQAMLPSYRDWYLGTDQTFAYEYLRTALKAVTWQRGGGRWVLKAPQHLEQLGPLTSVFPDATVVITHRDPVAVTASLTTMLCYGLRMTTAPIDPHAVGAYWRDRAAVYMERCLRDRDLVPKEQSIDVLFHEFMADDIAMVERIYEVAGQPFTTETRAAMEAYMAEHPRGRHGRVDYRLADIGLDLAERRSALAPYAERFGTKEEQVKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CER1</accession>
    <name>A0A1H6CER1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion system (T2SS), protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_109277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71499">
        <property type="protein sequence ID" value="SEG71499"/>
        <property type="gene ID" value="SAMN04489712_109277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG71499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="132" mass="13582" checksum="3C1893A7D51D1A25" modified="2017-01-18" version="1">MSGAADIDVVLDRLSVRPGAEGLRILAACWRIGADKGGTFAAVVEGLATALRDEEAQRQEVAAQLAGPRATARLLAGLPLLGLGMAAALGADPLAFLFGTVPGLVCLALGVGLDVLGLWWTHRLARAAEVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CK76</accession>
    <name>A0A1H6CK76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purL</name>
        <name evidence="10" type="ORF">SAMN04489712_110106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73401">
        <property type="protein sequence ID" value="SEG73401"/>
        <property type="gene ID" value="SAMN04489712_110106"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="9">
        <location>
            <begin position="308"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="388"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="503"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="746"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="878"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="395"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="614"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
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        <location>
            <position position="802"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="839"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
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        <location>
            <position position="842"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG73401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1039" mass="107878" checksum="A4FE2EF73BA68552" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM28</accession>
    <name>A0A1H6CM28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron complex transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="24"/>
            <end position="334"/>
        </location>
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        <location>
            <begin position="59"/>
            <end position="330"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG74012.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="334" mass="35329" checksum="4DD7E709C3A61569" modified="2017-01-18" version="1">MRTLMRRLAATGALVLGLSLVAACGGDGEEPAGPAGSGAFPVTITHKLGTTTIKAEPKRIVALGEIDQDTLLALGVQPVGMAELTGVQDDGLAPWSAPKLSGEKPKLLKAGESGFNLEEIAALRPDLILAGGDFYIDKEYDKLAKLAPTTAYQTGPAEDSWQTVARQVAKAVGKEAEGERLVADVEAKINSVKTAHPALTGKEFAFTSVFPSGNIGVMKSADDVSVKMLSQFGMVLPEKLQSLPGEGFAAELSMEKVGVLDVDVLLSHYNDDPATQRKFEDNKLFSGMDVVKRGSYVPLDLKSFWPLRTPTPLAVPYVVDQVVPKIAQAAEKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT19</accession>
    <name>A0A1H6CT19_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WxL domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">SAMN04489712_111134</name>
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    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
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            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Thermomonospora</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
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    <dbReference type="EnsemblBacteria" id="SEG76189">
        <property type="protein sequence ID" value="SEG76189"/>
        <property type="gene ID" value="SAMN04489712_111134"/>
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        <property type="entry name" value="Neocarzinostatin-like"/>
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        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
        <property type="entry name" value="WxL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49319">
        <property type="entry name" value="SSF49319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295164" description="WxL domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="3">
        <location>
            <begin position="214"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG76189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="330" mass="33004" checksum="39C71283A672B390" modified="2017-01-18" version="1">MKFAFRRVLRGTAVMTGAGLLGLGLTAAPAHADSLSVTVTPTAEADPDGQDIRVTGSGFDPGKNNGFGIYVAFGPKNGDDWYTNANAFQATKWVHKNASTSPGQAKLNADGTFDLTLTGIKAQYTDGDGNQVDCLTTQCYVLTFTAHGLPDRSQDTLTPVTFVGGENPGGENPGGENPGGSSKDQLITTNVTRVGALSLSVAGTNVTLSDAEPGGNSTGTLNTATVTDARGTDAGWSLVGQMSDLAAAEGGAIPAANMAWTPNAAVVNDGSNGTVVPGPSVRGLDAARTLASSEAGASGGIFQAGAGLDLLIPAGAAPGAYVGTLTLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTU9</accession>
    <name>A0A1H6CTU9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_111163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76430">
        <property type="protein sequence ID" value="SEG76430"/>
        <property type="gene ID" value="SAMN04489712_111163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG76430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="608" mass="62942" checksum="DD3EF5D52CC18A74" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTV5</accession>
    <name>A0A1H6CTV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative hydroxymethylpyrimidine transporter CytX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_111159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76394">
        <property type="protein sequence ID" value="SEG76394"/>
        <property type="gene ID" value="SAMN04489712_111159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG76394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="459" mass="48428" checksum="64081AE6339DE7EE" modified="2017-01-18" version="1">MKSVLRASREAAPRDEAPYTLDEPAPKVLGFWDQSAFWANLGVSLFAFSGAYTVLAPDEDGAARLPVTAGIAAMVVGTVLGGLMLGLAAVPGARTGRPAMVLLRGLFGARLSYVPTALNIVQLIGWGTFELIVIADAARQLYDGVPRWAYAVAAGLLTTVLAIWPLGSVRLLRRYVTAAVMVALVYFYVQLLREPLPDLGLVPGSGSDAASWSLFWVGADAALAVSISWVPLAADYTRHARSARGAFGAATVAYAVTQIVAYVLGLLALALVAGNSAEVYSPFLGVTLGAWFFAVFVLREADQSFANVYSTAVSIQNIVPRADRRVLAVLLGAMITGLALVLDMGDYAGFLSLIGSLFVPMLGVLAVDFFLGRGRRGWDLSAAAPPRWGMIAAWALGFVAYQLINPGTVAGWSAWWTDLRDALGFAPQTWMSASLLSFLVAGLAAGVIGRLRPGRGTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYN6</accession>
    <name>A0A1H6CYN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78269">
        <property type="protein sequence ID" value="SEG78269"/>
        <property type="gene ID" value="SAMN04489712_11255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="45"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG78269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="153" mass="17436" checksum="20E41739A477EBDB" modified="2017-01-18" version="1">MALQQPTHRPGRTGLFFDPEREFEDLYDRLGQLLGFPVSGPAGPHVQAPWVPLADISETEDSYVVELDLPGVRKEDLDIQLNDQVLTVTGETKEEEGKRFRRRTRRTGRFEFRAQLPSDVDPNQVEAHMEHGVLQIMIHKAEAAKPRHIEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D550</accession>
    <name>A0A1H6D550_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80184">
        <property type="protein sequence ID" value="SEG80184"/>
        <property type="gene ID" value="SAMN04489712_11334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="15495" checksum="91A46371CA7794C5" modified="2017-01-18" version="1">MEMVTLGLPPSRRPALFSWTVVTRHDDLRRVGACGVCDDRARAMRHLGEALLEAPAGAVGLVHRVTVGVAGLGYLYDGLIARACLDPATGTIDWLEMGCPRWAWGPRDALLDAVTGRAGDPLPPEAVALGLADPQAESGHRGRPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5L7</accession>
    <name>A0A1H6D5L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80669">
        <property type="protein sequence ID" value="SEG80669"/>
        <property type="gene ID" value="SAMN04489712_113127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295550" evidence="2">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="188" mass="19841" checksum="BE1F1388ABC070DF" modified="2017-01-18" version="1">MDSKARSVAAALALAVLPVAAAACGTSTSGGPGQSPGSRSSSHSPLPDQSALASAAARIDAHLRRSFPDHYAGVEIDPSRSVVIVYRRPSSALDADLRARFGDVPTRLHDAPHSARELDRLAARLRDDTGYWRERGVSITSLAVRPDGTAVVVGTDDVAKATRELPRRYGRAPLKIIHATPQLPTSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6N2</accession>
    <name>A0A1H6D6N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80608">
        <property type="protein sequence ID" value="SEG80608"/>
        <property type="gene ID" value="SAMN04489712_113112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="36"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="32848" checksum="F97A50112F37FA3E" modified="2017-01-18" version="1">MSRLGLGLAALGRPAYINVGRADELPDERGVAAMRAATRRVLDAAYAAGIRWVDTARSYGLAEEFLAGWLDGHDDVTVSSKWGYAYVGGWRMDAPRHEVKEHSAERFRTQLAESRALLGDRLSLYQVHSLTDDSPLFRDGPLLAELAQAAADGLRLGFSTSGPRQAETIGRALGLEVEGRPLFSAVQSTWNVLETSAEQALREAHEQGLHVLVKETLANGRLAVDPPEELVALAEIRGVGPDAVALAAALSRPWADTVLIGAVSEPQLHANLAATRITLGEAELAALAGAAVPPARYWAERAALPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8S0</accession>
    <name>A0A1H6D8S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_113168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80876">
        <property type="protein sequence ID" value="SEG80876"/>
        <property type="gene ID" value="SAMN04489712_113168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG80876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="25199" checksum="E5CC1A565F63AC5D" modified="2017-01-18" version="1">MAEQTQGGTLPAAGREADVRPPLTYDRIIRTAIALIEREGVAALSMRRVGGELGVAAMSLYNHVPSKEAMLDGVAEEILSGLRLDAGPQAGWRDRIRDLAHAFRRTAQEHPRSMSVVLSRSMDWTRSLPVLEQMLTIAEQAGFQGETAVRVMRTFMAYVMGTLMREASTADALWHIAQDGVRAAEMVDPAAFPHVVATARELLDPDFDADFDFGLELLITAIERLPRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8S6</accession>
    <name>A0A1H6D8S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMI1 / KNR4 family (SUKH-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81253">
        <property type="protein sequence ID" value="SEG81253"/>
        <property type="gene ID" value="SAMN04489712_1148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="16526" checksum="595EA53EF77CD283" modified="2017-01-18" version="1">MWRELIERHTSQARFASPATKQALYRAEETLGHLLPDDLAELLGETDGVVDGNGYNLVFSAEQLVQGNVEMRTYPALKRLYMSFDQLLFFSDVPRDGNLFAYALVPEGRPDIFVWDHRTDNRRRVAPSLEHFIEAWLTDDIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DA18</accession>
    <name>A0A1H6DA18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 17">Aspartokinase</fullName>
            <ecNumber evidence="7 17">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SAMN04489712_11510</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7 17"/>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82327">
        <property type="protein sequence ID" value="SEG82327"/>
        <property type="gene ID" value="SAMN04489712_11510"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
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        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="12 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="267"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="349"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SEG82327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="422" mass="44402" checksum="B4CE415D4CF037B2" modified="2017-01-18" version="1">MALVVQKYGGSSVADAECVKRVAQRIVATKKAGNDVVVVVSAMGDTTDELIDLAEQVSPLPPGRELDMLLTAGERISMALLAMAIANLGHEARSFTGSQAGVITDDSHGKARIIDVTPGRIRSALDDGSIAIVAGFQGVSQNSKDITTLGRGGSDTTAVALAAALDADVCEIYTDVDGVFTADPRIVPTARRIPSISYEEMMEMAACGAKILHLRCVEYARRYNIPIHVRSSFSQRTGTWIADSTEGSEMEQAIISGVAHDRSEAKVTVVGVPDKVGEAATIFSVLSDAGINLDMIVQNVSAAATGRTDISFTLPATDGQTALTALNKVKERIGFESLQYDDRIGKISLIGAGMRSHPGVTAKFFSAIAEAGVNIEMISTSEIRISVVVSQDDVEAAVTAAHRAFELDADQVEAVVYGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DB19</accession>
    <name>A0A1H6DB19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82491">
        <property type="protein sequence ID" value="SEG82491"/>
        <property type="gene ID" value="SAMN04489712_11534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG82491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="22271" checksum="8490B0CF324B9D44" modified="2017-01-18" version="1">MAEPAKLVRAIGLGHRFPGTAELFSGLTFELHPGQVTGLCGPSGSGKSTLLSILAGWVAPAEGTLERTGVSRTGWVFQNPYGVPRRSALDHVSLPLLAQGWTRGQAERRALEVMADFGLTAVADRQFRRLSGGEAQRLMLARSVCSAPDLLLVDEPTAQLDLRTARTVNRTLGAIAQDGTIVVIATHDPDTRAVCTRVIDLAERGRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEB6</accession>
    <name>A0A1H6DEB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_115132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83053">
        <property type="protein sequence ID" value="SEG83053"/>
        <property type="gene ID" value="SAMN04489712_115132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG83053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="540" mass="56049" checksum="B2A82B867432BB41" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DG24</accession>
    <name>A0A1H6DG24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_116136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84062">
        <property type="protein sequence ID" value="SEG84062"/>
        <property type="gene ID" value="SAMN04489712_116136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG84062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="15195" checksum="89E535A807877972" modified="2017-01-18" version="1">MERRHRLRQIVNVANLSTPLGVLLARTGTGGLRRGPQGLLIGTGYRLPLPVAPAFTVGNVVLVRGDGSVLERRPRLLAHEARHATQYACCLGPLMIVLYLAGAGLSMALCGDHASYNPFERLAGLEDGGYTKRPLRFTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJ29</accession>
    <name>A0A1H6DJ29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84695">
        <property type="protein sequence ID" value="SEG84695"/>
        <property type="gene ID" value="SAMN04489712_11751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="33430" checksum="6356D09CA8AD8A3F" modified="2017-01-18" version="1">MLDLHRARILREVARLGSMTAAAQALSYTQPAVSHHIARLEGEVGTPLVVRHGRGVRLTEAGRVLVEHVEAVLARLADAEEQIAAIAGLRAGRVRVAVFPTAAAGLLPDALVALRARAPQVTVSLREEEPPGALAALRAGEVDLAVVFSYTEGEGEGGAAGLRRVPLLTDPVRLAVPAGHRPSGAAGVRLADLAGQTWASGCQRCRGHLVRACRAAGFEPKIAFATDDHIAVQRLVGRGLAVTALPALAFTLHREPGVAVLAAAELGRRHITALVPDGPRPPAVAALLDELVAAAAALPDVAQQVAGGTGPAAPRALDVGPAAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJ60</accession>
    <name>A0A1H6DJ60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system, OmpR family, response regulator MprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84646">
        <property type="protein sequence ID" value="SEG84646"/>
        <property type="gene ID" value="SAMN04489712_11741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="155"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG84646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="257" mass="28375" checksum="232FE267905741BF" modified="2017-01-18" version="1">MESDRAADRPARVLVVDDEPAVREALVGSLEFEGYRVTEAADGLAALERLGSDPPDLVVLDVLMPRMDGLTACRRLRAQGSMVPVLMLTARDMVGDRVSGLDAGADDYLVKPFELDELLARVRALLRRGTMTAQLTARANQTAQAAQAVELAAPGEVLAFEDLRMNTVTREVARAGTPLELTRTEYMLLEMFLLHPRQVLAREQILETVWGFDFEPASNSLDVYVMYLRRKTEAGGRPRLIHTVRGVGYVLRAAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKU3</accession>
    <name>A0A1H6DKU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_118139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86047">
        <property type="protein sequence ID" value="SEG86047"/>
        <property type="gene ID" value="SAMN04489712_118139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010866">
        <property type="entry name" value="A-2_8-polyST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07388">
        <property type="entry name" value="A-2_8-polyST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="443" mass="48769" checksum="58679C097165DC92" modified="2017-01-18" version="1">MTQIFVSSRLFGAMSLAAAVDAGLFGPPGRRRILLVSHDAEIPELTPPPNERPGYRPLLSRFDEVISLNEVIAPQHPLSWNPRPEDLPMLERLLRQVWGLGADPVELAVEAIQSSPAKTLAAIFHEATVTVYSDGLATYGATRATPPRGVGSRLSRLVHLDLVPGLTPHLLSEYGAPGQELPGEAFLKVLDEVCAEIDPLISRYGTLGEHDNAALIVGQYFSELGILEPDEEDQMHLEMLQGVVARGHSTVLFKPHPHSPPRLFELLTDEAKRLGARLVIIDDPVPAEAWFARARPALVVGICSTAMMTARCYFGIPTVTLGVVRLLRRLQPFENSNRIPASIIDAILPRLMPDGTLQPPMIGPQEVESKLVPLVTSIAYCMQPGRRPDLRRTAVEYLSSFDPDDIPRRYFRPRLYQLGLPGGRAPVEQTPAWRPSLRGLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL24</accession>
    <name>A0A1H6DL24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, contains XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_118107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85918">
        <property type="protein sequence ID" value="SEG85918"/>
        <property type="gene ID" value="SAMN04489712_118107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="14896" checksum="163669F0A042C0D5" modified="2017-01-18" version="1">MTGSKVGSIGEYIRDQRQRAKISLRQLADVSGISNPYLSQIERGLRKPSAEILQQIAKGLRISAEALYVQAGILEEREADTDVQAAIRADLILTERQKQVLMDIYESFRKENEAAVAAAGPQAPGADAPGTTVQNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLX4</accession>
    <name>A0A1H6DLX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase, middle domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_11918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86204">
        <property type="protein sequence ID" value="SEG86204"/>
        <property type="gene ID" value="SAMN04489712_11918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="51"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="167"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="279"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG86204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="436" mass="47209" checksum="752BB2165517AADC" modified="2017-01-18" version="1">MSVDTTTPTAGRPAGDGLPGQEPMFDVVRDVWDPATLDPEPTYDGMWAELTPRQREIRELAREVAVRELRPMAGHWDETEEFPRKTFEAVLETGLVGLTIPKQYGGQGETLLEGCIVVEELARACLSTAMAVQPFLNGPWRAINVLGTEEMKNRLLPGVADGTNHFAIAMSEPAAGSAGTDLRATLTPDGDGFRLTGTKCWITGGHVADTIIVFARLAGTSGPYGIGAVVLTERPDGMGEFHIDPKMGIRGVAECLVHFDNVRIGPENVLVMPEEHSKKGTGILVNQFNPERCGNAAMCTGLGQAALDASIGHLNARRQFGRPLAEFQGLQWKIADMALDVHVSRMLVWRAARSGDGGFPDQTETLMAKLHSSEMVQRVTNAAIGVHGARGYSRRWPVERYFRDGRGLVMGGGTPEVMRNVLGAQMLGVSGSQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DM91</accession>
    <name>A0A1H6DM91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86309">
        <property type="protein sequence ID" value="SEG86309"/>
        <property type="gene ID" value="SAMN04489712_11949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="419"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="523" mass="56524" checksum="4443344A2A2D58C6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMH2</accession>
    <name>A0A1H6DMH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85795">
        <property type="protein sequence ID" value="SEG85795"/>
        <property type="gene ID" value="SAMN04489712_11881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="122"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG85795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24755" checksum="E4EEBCA1F31DE3DD" modified="2017-01-18" version="1">MRDIYHEELDGLSDRLVEMTRLVRQAMTQAVTALLDADLRLSEEVIGGDDRVNKIDAEIEETVFDLMARQQPVAGDLRTLITTLRMSGDLERMGDLAVHIAKTARRRHPESAVPPELTVTVLEMGQIAERMVAKAGSVIASRNVEMGLELDADDDAMDRLHRRLFDVLLSPKWTHGVEPAVDITLAGRYFERFADHAVHVAENMVYLITGQRPAEINDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DN85</accession>
    <name>A0A1H6DN85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase family enzyme, contains CxxC motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86631">
        <property type="protein sequence ID" value="SEG86631"/>
        <property type="gene ID" value="SAMN04489712_119131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="60"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="213" mass="24184" checksum="33EF4DC8DC635C45" modified="2017-01-18" version="1">MPRLREVPRAEVTDERILFFYDRLFAPDRDPAVDHGTATGTPGDWWTVFAQDPDVFRHAVRGFALYRNARLDPLLRELGQCRAGWARGSQFVFSQHCKQMRALGMPEEKIQAIPHWQTADCYDRLERAVLAYTDGIVLDGGRVADEIFAVLKEHLSDQEILALTYITCLYEMHATMSKVLRLEFDDRPEPVTEVAAPEGYGARDISADLAGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNL1</accession>
    <name>A0A1H6DNL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylglutaconyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86353">
        <property type="protein sequence ID" value="SEG86353"/>
        <property type="gene ID" value="SAMN04489712_11960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="245" mass="25691" checksum="5AB88589512D0486" modified="2017-01-18" version="1">MSITVTDEHGGRVARVTFDNSARGNSFDLPLLRELTEALETAAAGPSRVLIRLDMAGRHFCGGWDTSSFEDLANESAETVANRLRTGDELLDRIRRLPTPVVAAVRGQVIGFGVGLLSALHLPVADAATRVSLPEARFGLAPAGVGHVVTQALPRAQAYALLSGLTTATGRQLFSWGLVAQVVDTTDDLDAAVAKMIDGLLAVPGDTLRAVVEVVESSLETGLPDHAYETSARTIVSAGQKGDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPN0</accession>
    <name>A0A1H6DPN0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate guanylyltransferase</fullName>
            <shortName evidence="1">PEP guanylyltransferase</shortName>
            <ecNumber evidence="1">2.7.7.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbiD</name>
        <name evidence="2" type="ORF">SAMN04489712_12099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine</text>
            <dbReference type="Rhea" id="RHEA:30519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:143701"/>
            <dbReference type="EC" id="2.7.7.105"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CofC family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.105" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87262">
        <property type="protein sequence ID" value="SEG87262"/>
        <property type="gene ID" value="SAMN04489712_12099"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02114">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01983">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="228" mass="23144" checksum="64242FF318C38D8C" modified="2017-01-18" version="1">MAAETSCDDGLRWSLVLPVKVLARAKTRMAAAAGPLREALALSVAADTAAAALRCPAVAEVIVVTDDPLAAAELSALGARVVPDEPDRGLNPALAHGAALARRDRPDAGVGAMSADLPALRPAELARVLEAAARAPESFVPDALGVGTTLYTARPGVPFSPAFGTGSRARHAAQGARELLMDGIDSVRRDVDTPDDLRAALTLGAGPRTAEIAARLPALSPGGGTWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPY8</accession>
    <name>A0A1H6DPY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_119129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86625">
        <property type="protein sequence ID" value="SEG86625"/>
        <property type="gene ID" value="SAMN04489712_119129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="418"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="509" mass="55712" checksum="E80BB37F968A391A" modified="2017-01-18" version="1">MLINDIIEFAARKHPGRTALRFEEQVITFAGMRDRIRRVANALRTVAEPGDRVAVLSGNRPEYVDLYYGVPAAGMALTFLNHRLHPSEIAALVNHAQASVLIVSGEHLGAMSEHRAAMPTVKTVIALDGGGDADYTELVSAASTAEPPRVDEDSVAWLVYTSGTTGRPKGVMLSHKNLLTGVISSVAHWNVPDDQVFLFCFPLCHVGGYVVLVNHLRSCTVGILRAYDNATFLRLVAEWKVTNTGLAPTMIAFLLRHPGIEDEDLGTLRAIGYGASAIPAEVLRRGMEVLGCDFYQGMGMSELGGNILHFGEAEHRRAAAGETHLLAAAGRPMDLASIRIVDPDFNDVPPGEPGEMLVRGDQVMLGYWREPELTEASFRNGWFRTGDVVRQDAEGMVYIVDRLKDMIITGGENVASREVEEILYRHPAVQDVAVFGVPDPQWGESVCAAVVLREGSAEDPDSIIAFAREHLGGYKVPRRIEFIRELPRNIAGKVLKRDLRAVHIAKDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRX5</accession>
    <name>A0A1H6DRX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88127">
        <property type="protein sequence ID" value="SEG88127"/>
        <property type="gene ID" value="SAMN04489712_12182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF35_N" evidence="3">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="2">
        <location>
            <begin position="59"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG88127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="558" mass="60141" checksum="88FE3227ECC5F591" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVJ4</accession>
    <name>A0A1H6DVJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Stearoyl-CoA desaturase (Delta-9 desaturase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89094">
        <property type="protein sequence ID" value="SEG89094"/>
        <property type="gene ID" value="SAMN04489712_12320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="58"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG89094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="35637" checksum="B318A7D51674BDB6" modified="2017-01-18" version="1">MATVTVKETGWARQRDLSPHPVPLVERIAVVLFVGVPILAACAAVPFVWGWGMGWTDVAILAVLYPLNAIGITVGYHRHFTHGGFKAKRWLRITLAILGGQAMHGSVIRWVADHRRHHKYADAEGDPHSPWEYGPGLVGLTKGLFHAHMGWLFTKDRTSRRRYAPDLLADPDIRFLSLNPVYALIVLSTFAVPFALGALLTWSWHGAVTALFWGGLMKVFFGDHITFSINSICHVFGKAEFRTRDRSRNVWWLAIPSFGESWHNLHHADPTCARHGVLKGQIDISARVIWAFERLGWVWDVRWPDEQRLAARRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXT6</accession>
    <name>A0A1H6DXT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90147">
        <property type="protein sequence ID" value="SEG90147"/>
        <property type="gene ID" value="SAMN04489712_12552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="30"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG90147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="489" mass="50914" checksum="D4B2F11104BB0BAE" modified="2017-01-18" version="1">MSTRQQDARVIDGNRRPEWARSAVYVDGGWRETAAGRTVEVENPATEAVIGTAADAGVADTEAAVSAAAAAFPSWSALPPPERLAVLERVYTGLERRRDLLVETTIAEIGAPLRVAREAHVDTGMAVLRAYLDAAEELAWQERVGNSLVLREGIGVAACITPWNYPFYQVLAKIGGALVAGATVVLKPAELTPLSAYLLTDTIDEAGIPAGVFNLIPGPGRVVGEALAGHPAVDAVSFTGSTRVGARVAALAAASIKRVSLELGGKSASVILPGADLEPAVRASVEAAMLNSGQTCTAWTRLLVPRADLETALRLAAARADTLVVGDPTRPETDLGPVASPAQRHTVTGFIERAVADGARIVTGGTERPAGLARGHYVRPTIVTDVAPDAEIVQEEVFGPVLTVQPYDSIEEAVALANGTPYGLAGAVWGPDQGAAVAVARRLRTGQVDINGGAFNPAAPFGGYGRSGNGRELGRWGIEEFLETKALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZX0</accession>
    <name>A0A1H6DZX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90898">
        <property type="protein sequence ID" value="SEG90898"/>
        <property type="gene ID" value="SAMN04489712_12771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="284" mass="32091" checksum="F347F67FDDCD4315" modified="2017-01-18" version="1">MVNAQRPDRAASLRKGLRRRSELLAAAVRPPGRGPAPLLAPSKTPRLVPSPVFVLSCQRSGSTLLRVLLNSHSRIRAPHELHLKTIQVRLTASFAPDIMGELGLDQRELEHLLWDRILHHELHRSGKSVIVEKTPSNSYNWRRIQRAWPQARFVFLLRNPATIVGSVMNRRGGAVREDVVAEVLKHAEGVESAREHVPGLTVRYEDLTADPERETRRLCEFLEVEWEPGMLDYGKQDHGPFKAYFGDWSSNIKSGRIQPAREPAPDEKVPAELADIARAWGYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2Z0</accession>
    <name>A0A1H6E2Z0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91255">
        <property type="protein sequence ID" value="SEG91255"/>
        <property type="gene ID" value="SAMN04489712_12873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="24782" checksum="588E6766D989B9E8" modified="2017-01-18" version="1">MSPQESPQERPIRVFLMDDHEVVRRGVAALLSAEDDIEIVGEAGTARQALDRIPAARPNVAVLDVRLPDGDGVSVCREIRSAMPEVACLMLTSFEDEDALFDAVMAGASGYVLKQIHGSDLVGAVRTVASGQSLLDPRSTARMLQRVRDRAARKDPLAALTDQERQILELIGEGLTNRQIGERMFLAEKTVKNYVSNLFSKLDMRRRTQAAALAAQLKADREGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E534</accession>
    <name>A0A1H6E534_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92343">
        <property type="protein sequence ID" value="SEG92343"/>
        <property type="gene ID" value="SAMN04489712_13322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296556" evidence="2">
        <location>
            <begin position="18"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="29076" checksum="8E3BB5EFB031D369" modified="2017-01-18" version="1">MIAVLLALVASLCNATASVLQRRGTLAVPEGAGPLLFARTLLRRPVWLAGIAALIGGFVLQAAALGFGGLSLVEPLLVMELPFTMLIIALFFRARLSAQTWLATVAMTAGLAGLLVAAAPGAGISAPATADWVLAALGVACAIAAMLVAAWLVRGSRRTVLLGAATGVGFAFTAALMKGSTGILKSDPVQALTSWQPYAMVATGLFSLMLLQVTLHSGTLVAAQPPLTIIDPVASIILGALLFDEPIRAGPWIALELVGVGLIVYGAIEISRTPAFHGAAVPLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E587</accession>
    <name>A0A1H6E587_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92045">
        <property type="protein sequence ID" value="SEG92045"/>
        <property type="gene ID" value="SAMN04489712_1322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296617" evidence="1">
        <location>
            <begin position="33"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="170" mass="18621" checksum="1F157DEEA50446B1" modified="2017-01-18" version="1">MRVAAGRPRLRRRLVVPGVLLMALTGACSSFAADDRPVSPSASAPVVRTDREPIARRFPALGDFRQVHWLGGVVGGAPSARDTVPGPSTYWIHAVVVPDEAGYRRIVTRFTWNEAPRPEVDEPLAAKVDLSGEWATGPDYWTHLAPGPGYTGTVHLNRTHRYLYLTVTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5B3</accession>
    <name>A0A1H6E5B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold-shock DNA-binding protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92399">
        <property type="protein sequence ID" value="SEG92399"/>
        <property type="gene ID" value="SAMN04489712_13342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="131" mass="14300" checksum="6520551857631420" modified="2017-01-18" version="1">MPTGKVKWYDADKGFGFLTRDDGGEVFVHSSALPSGVTSLKSGQRVEFGVVEGRRGQQALSVRTLETPPSVEKSVAKARRKKPDEMVLIVEDLIKLLDGISNTYRRGKHPAPTEAKKIATVLRAVADDLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5P1</accession>
    <name>A0A1H6E5P1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_13435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92563">
        <property type="protein sequence ID" value="SEG92563"/>
        <property type="gene ID" value="SAMN04489712_13435"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG92563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="443" mass="48208" checksum="597EA0D627779D73" modified="2017-01-18" version="1">MPLPPTCGPADHVHDLVGIGFGPSNLALAIALREHDAADGIDAVFFERQPAFGWHRGMLIEGTTMQVSFLKDLVTMRNPASEFSFLHYLKARGRLADFINHKTMFPSRAEFHDYLEWAAARFTDQVEYGAEVVAVRPVPGDGPVEAVEVVVRRGGGSGELVTHRARNLVIAAGLEPVLPPGVTAGERVWHSHELLHRAGGLREPKRLLVVGAGQSAAEVTEYLHRTFPSAEVCAIFTKYGYTPADDSSFANRIFDPEAVDHFYAAPEDVKRMLLDYHHSTNYSVVDLDLIDELYRRAYQEKVTGARRLRILNVSRIAELDAGPAAVRATVEFLPTGERTTLEADALVYATGYRVGDPAALLGEVGEHCLRLPGGALSVGRDYRVATTDDLRCGIYLQGATEHTHGITSTLLSNTAIRVGEIVESIAAAKAAAPPSPYALSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5Y3</accession>
    <name>A0A1H6E5Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93102">
        <property type="protein sequence ID" value="SEG93102"/>
        <property type="gene ID" value="SAMN04489712_13713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="292" mass="31014" checksum="0C199EDF775BE1D0" modified="2017-01-18" version="1">MGEVLTLPVPEMVHGTYAVAAGAPPGDPMELAREQVTRRVPAPLRELALGMLGSPLLTLDLRPAGKFPPLPTDLLAAFGASSGQVAEVSAATHVCAVRAAYQPGWPPAHEWAARAVAGALGAALDAPVVDVFTPQVLDPDRLWRSLPDERGHTRLVDWMLLAHTEGPAGFWFNTKGLARFGLPELHAEDVPADLVEPCGQLLNGLARRLLDLWVEELRAGQRSAFAELPETVPIGPADVAAAHGAPDPRETRRDVRVRLRLDTTESQALLTVLPPGPDAADGVAGLCTRLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8N6</accession>
    <name>A0A1H6E8N6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_13913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93489">
        <property type="protein sequence ID" value="SEG93489"/>
        <property type="gene ID" value="SAMN04489712_13913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="14"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG93489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="125" mass="13133" checksum="03827045AC13752D" modified="2017-01-18" version="1">MRKVLTNEPQLDIATEAAADTNGWVIIRATGELDLATAPRLLEHVTGLTEDHRCPHVVLDLADLGFCDSTGLGTLITLHKRMQAAAGVLVLAGLTGQPLDLLARTGMDRRLALAADVAAATARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8Q4</accession>
    <name>A0A1H6E8Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Superfamily II DNA or RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94120">
        <property type="protein sequence ID" value="SEG94120"/>
        <property type="gene ID" value="SAMN04489712_14315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="1418"/>
            <end position="1560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1560" mass="174601" checksum="1C75FE16F164E1E4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9D7</accession>
    <name>A0A1H6E9D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93554">
        <property type="protein sequence ID" value="SEG93554"/>
        <property type="gene ID" value="SAMN04489712_13929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG93554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="17760" checksum="6683E6D5B86BECCD" modified="2017-01-18" version="1">MIETDLTALLLRATVGATMIAHGWNHAFGGGRLAGTARWFESIGIKPGRVHAALATATELGAGVLLLVGLGNAAAAGAVLGTMLVALVANHLRNGFFIFNKGEGYEYVLMISVVALALAALGPGRVSLDHLLGLQEIAGHALTGWTGLLTAAAIGAGGATALLALCWRPTDTGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAE8</accession>
    <name>A0A1H6EAE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000044">
        <property type="protein sequence ID" value="SEG94213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94213">
        <property type="protein sequence ID" value="SEG94213"/>
        <property type="gene ID" value="SAMN04489712_14410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="57" mass="5733" checksum="502CE743A75EC709" modified="2017-01-18" version="1">MGKTTTSIGLGEALGQSSGGAMPIDVDGPPLQAAYDNVAAYNRAALLFPLPADADEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB89</accession>
    <name>A0A1H6EB89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94531">
        <property type="protein sequence ID" value="SEG94531"/>
        <property type="gene ID" value="SAMN04489712_14815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="16077" checksum="32772BFD382ED320" modified="2017-01-18" version="1">MLRLNVDMKSSATMSIGELAGHFGLATHVLRHWETMGLLSPARAAAGHRRYGRSDLYRVASILLAKEAGLALTDIRDILTTADVEKRRRIQRRHRDELVRRIVEMRAALSFIEGGLDCDYEDITECPNYQSLVADRMSMHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SKE4</accession>
    <name>A0A1H5SKE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50418">
        <property type="protein sequence ID" value="SEF50418"/>
        <property type="gene ID" value="SAMN04489712_101226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF50418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="28010" checksum="8047BA49D02FFDDC" modified="2017-01-18" version="1">MALCQIPVGDDPEENLQEVRKALGRAEGADLAVFPEAVQVRFGNTLADVAEPLDGPFVGELRRLAREHGTALVSGVFEPAGDGRVYNTAVAIDAAGGLAGTYRKIHLFDAFGDHESERVAPGDRPVVVELAGTRIGLVTCYDVRFPELARALVDQGAEVLVVIAAWAQGVFKEEHWTTLVRARAIENTTWVVAVDKAPDRTPPPKGNPGGVGRSMLVDPMGTVLADLGPFPSVQVTELDPEVTGRVRRFLPSLAHRRPDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SSE1</accession>
    <name>A0A1H5SSE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR C-terminal helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53445">
        <property type="protein sequence ID" value="SEF53445"/>
        <property type="gene ID" value="SAMN04489712_101343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="341"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF53445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="419" mass="46116" checksum="ACD8FFD6FF49865B" modified="2017-01-18" version="1">MSSLGSLEADDGRQPWRNVPREVALNFRPFVPLVAEEAVAAIRRQVPEYVRPADPKYDEVLRGAVEKAIGHFVDLIADPDTPWDDTLEFFRDVGYGEAREGRTLDPWEVALRLGARLAIRALGEQSGRLGISRQTLGHLAEGVFAYLEVLSAAAVRGHAEATARAAGELQNRRRRLMELLLTDTAAPQAVEDLARLARWPIPRTLCVVVFHERGEIGFRPPALPPEVLVDIDRGDPCAIVPDPDGPGRRAMLNGALHGWVAAAGPTVDPMADPAQTARSLRWARAALALARRGLLPDDRLVVATEHMPALAVMRSEELVALVAARRLEPLTGVRPSQRVRLARTLLECLRCGFNATEVAGRLQVHPQTVRYRLHQLQDLFGEELYDLERRLELEMTLVAWLARALPGAASADSEADPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SSW1</accession>
    <name>A0A1H5SSW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53676">
        <property type="protein sequence ID" value="SEF53676"/>
        <property type="gene ID" value="SAMN04489712_101351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF53676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="184" mass="19778" checksum="FDE6D597DF67CE62" modified="2017-01-18" version="1">MADELRGKTVAFLVAPEGTEQVELTEPWRAVEDAGGRPLLVSTQSGRVQAFNHLDKADTFAVDTTVEVSGADEFDALVLPGGVANPDYLRTQPSAVAFIKAFFTAGKPVAAICHAPWTLIEADVVRGRTLTSWPSLRTDLHNAGAHWVDQEVVVCHDGPNTLVSSRKPDDLKAFCQATVEALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5STG6</accession>
    <name>A0A1H5STG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53734">
        <property type="protein sequence ID" value="SEF53734"/>
        <property type="gene ID" value="SAMN04489712_101353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF53734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="25772" checksum="30F37FDA5D9657F3" modified="2017-01-18" version="1">MKEWRDDPTRTLAPKLVASCPRCQENPSVPEPRADYAYLLGLYLGDGCISPAGDPTKAVWALRIMCANSWPGLIDECERAIRSIRPDNKVRRIPCTGCTEVKSVSRHWPCLFPQHGPGMKHTRKIELSLWQQEIVDEHAEELVRGLLHSDGCRVANRIRRPLKGGERWYEYSRYLFTNLSDDIRNIYTGALDRLGIAWKQNKPREISVARKDAVARLDEFVGPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SW10</accession>
    <name>A0A1H5SW10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54654">
        <property type="protein sequence ID" value="SEF54654"/>
        <property type="gene ID" value="SAMN04489712_101384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="77"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF54654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="333" mass="35802" checksum="486F55521DC65D7B" modified="2017-01-18" version="1">MPSARVALSRYPRPPKVPVLDGNQAAGKVKAVTSTPEAAESELSVALTDPRQAIGPTGRPLPVFPEPEPLTEHGPARIVSVCNQKGGVGKTTTTINLGAALAEQGRRVLLVDFDPQGALSVGLGKGDPRQLELTVHNLLLESSVGWEDIVLDAGVDGMDLLPSNIDLSGAEVQLVHEVGREYILAGVLKAAVPEYDYILIDCQPSLGLLTINALAASHGVLVPLECEYFAMRGVALLMETIEKVQSRINPDLEIDGVLGTMYDSRTLHTREVLQRIVQAFGDRVFHTVINRTVRFPDATVAGEPITYFDPSSMGANAYRELAKEVLMRWKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T2K4</accession>
    <name>A0A1H5T2K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv2161c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56311">
        <property type="protein sequence ID" value="SEF56311"/>
        <property type="gene ID" value="SAMN04489712_101435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF56311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="32437" checksum="CFAB7D4F1E200A05" modified="2017-01-18" version="1">MRFIFHYPEANGPDGDVLDAGPLREVAVAVERSGFDGLSLSEHPVPGARWMASGGHQTLDPFVALGYAAAATERIRLLTYLAVAPYRNPFLLAKAAATLDRLSGGRMTLGLGTGYQKSEFYALGVDMDERNALFDEALDVLPLHWSGEPFSYQGRHFSARDVIARPRPVQDPIPIWVGGNSRLSRRRVAERAQGWMPMSGGAQLSATARTPALSSVGDLADAIAELREAAAAAGRSDRIDVLYSYHGDGIQSPAVEPDRHREAFAELDKAGVTWVVVSSRTSDPSATFEFIEAFGSTYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T450</accession>
    <name>A0A1H5T450_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57566">
        <property type="protein sequence ID" value="SEF57566"/>
        <property type="gene ID" value="SAMN04489712_101476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="63"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="482"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF57566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="566" mass="60846" checksum="CCAB31E7E7141C19" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TA79</accession>
    <name>A0A1H5TA79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress responsive A/B Barrel Domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59782">
        <property type="protein sequence ID" value="SEF59782"/>
        <property type="gene ID" value="SAMN04489712_101545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF59782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="97" mass="10591" checksum="EDA43E1E8772AF95" modified="2017-01-18" version="1">MLRHIIMLRWTPEATEDQKKAAEAGFRALPGAIAQIRGLACGPDLGLSTGAHDFAAVLDFDGADDWRVYQGHPAHRALVDGLIRPILDERASVQFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TNL5</accession>
    <name>A0A1H5TNL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acylpyruvate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64405">
        <property type="protein sequence ID" value="SEF64405"/>
        <property type="gene ID" value="SAMN04489712_101691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF64405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="30335" checksum="9A66E315EB73F223" modified="2017-01-18" version="1">MKLATLRVDGSTRAVRLDGDRLVDLGAADLGELLSQGGWAANAAAVDASAARTYPAEGADFAPVVPRPSKVVCVGLNYKNHIQEMGRELPQYPTLFAKFADCLIGATDEIARPEETTEFDWEVELAVVIGAPARRARGAEAEAAIAGFTVLNDITCRDWQFRTREWLQGKMWDSSTPVGPYVVTPDELPGGVRPELEVRLSVDGEVMQHDNTGDLLFDPVALVEYVSTVVRLHPGDIIATGTPGGVGHARDPKRYLTGGERVVTEIQGIGRLENTVAEESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TWX2</accession>
    <name>A0A1H5TWX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66708">
        <property type="protein sequence ID" value="SEF66708"/>
        <property type="gene ID" value="SAMN04489712_101759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF66708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="50" mass="4944" checksum="1B6AB53D64E2FB53" modified="2017-01-18" version="1">MTGQVLSGDGQDGHERGPGLGHGPSCQGFVPAEAAAVTSLGGVKVQGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UVG9</accession>
    <name>A0A1H5UVG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78980">
        <property type="protein sequence ID" value="SEF78980"/>
        <property type="gene ID" value="SAMN04489712_10246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="45"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="96"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF78980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="31348" checksum="F89706FA44FE2655" modified="2017-01-18" version="1">MARRDIADAVADLPGAEIEVWDAGAVPSSVAEVEFYVPALLPSPASLEVMALMPRLRVVQLQTAGFDHVLPHLPDGVTLCNARGAHDAGTAEWVVGAIIASQWDFPGFAAAQREGRWDYRHPGVLTDSRVLIVGYGSIGQAVERRLTPFEVEITRVASRPRQGVHGPDDLPELVARADVVVVLVPAGPRTRGLFDAGLLARMPDGALLVNAARGAVVDTDALVAETLAGRLRAALDVTDPEPLPPGHPLWRAPGVFLTPHVGGSTAASARRVARLVRAQARRHLAGEPLANVISGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V1T6</accession>
    <name>A0A1H5V1T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81243">
        <property type="protein sequence ID" value="SEF81243"/>
        <property type="gene ID" value="SAMN04489712_102128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041642">
        <property type="entry name" value="KstR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17925">
        <property type="entry name" value="TetR_C_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF81243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="21595" checksum="ED2605ABB61482A2" modified="2017-01-18" version="1">MTDGRRQPARSRSQQERRKKIIKSAAALASRGGVEAMQMRTVAERAGVALGTLYRYFPSKMDLVVAVVDEELDLLEGSIAKRPPRSSTPAERALDVLTRATRGLIREPELTEALIRALMLTDLPVAFGDRMTTLLLHAATGQDEPIAVDDPRWAKARALSSAWIMEMIELLRGRSEVDQIHARLEIAAHRLIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V3S1</accession>
    <name>A0A1H5V3S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81830">
        <property type="protein sequence ID" value="SEF81830"/>
        <property type="gene ID" value="SAMN04489712_102148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF81830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="381" mass="41530" checksum="C3A2EB18221EE791" modified="2017-01-18" version="1">MRPESTAHRPPSVPGIVTAEDMLATAHSIVAQQEPSGAIPWFSPTAGVPGHVDAWNHVEAAMALTTAGLREPARRAYEWLRSVQRPDGSWPAKWVLGEVTEAGGESNHAAYVAVGVWHELLMTGDEEFARRMWPTVRRAVDFTIDLQTHRGEILWIRHPDGTPADHALLTGCSSIYQSLRCAVALAEHLQRPQPDWELAADQLGHVVARHPEAFADKSRWSMDWYYPVLAGPVRGADAARRLAEGWDTFVVEGLGCRCVSDQPWVTAAESCELVLALDAAGDRDRALELFATIQHLRHEDGSYWTGWQFENRRHFPGDRSTYTAAAVILAADALCGGTPGAALFKEIAGRPLGPSEPADPAACGCVPATQAPLANPVRTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V543</accession>
    <name>A0A1H5V543_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82429">
        <property type="protein sequence ID" value="SEF82429"/>
        <property type="gene ID" value="SAMN04489712_102169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF82429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="25925" checksum="3F74D0688BE47637" modified="2017-01-18" version="1">MEREIVLEGCVNFRDVGGYRAEGGHVRWRTLFRSDALHELTPEDAARLADLGVTTVIDLRSEYEREHDGEGAHPLAGAVSFVRAPIINQGNLTVMADTSLSLAGRYARILETCGTALADAVTAIAHAPGAVVFHCAAGKDRTGMLSAAVLGALGVDDEDIIADYAMTGRNLQRIGTRLRRHPAYENSYAYVPRDAMTAQGDTMRELLGDLRSRHGDLRGLLGAVGVGEDVLDRLRASLVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V5W3</accession>
    <name>A0A1H5V5W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polar amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82709">
        <property type="protein sequence ID" value="SEF82709"/>
        <property type="gene ID" value="SAMN04489712_102180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF82709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="27271" checksum="FB63D884AC76AB7B" modified="2017-01-18" version="1">MTHMVEIRDLHKSFGALEVLRGIDFTVDQGQVICIIGPSGSGKSTLLRCVNLLETPTRGQVFVEGEELTHPDVDIDAARRRVGMVFQQFNLFPHLKVLENVTIAQRRVLKRGKAEAEKVARDNLAKVGLADKAGSYPAQLSGGQQQRVAIARALAMNPDLMLFDEPTSALDPELVGDVLAVMRQLAEEGMTMLVVTHEMGFAREVADRVVFMDGGVIVEEGPPEQVIGDPQEDRTRTFLRRVLDPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V7V0</accession>
    <name>A0A1H5V7V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82537">
        <property type="protein sequence ID" value="SEF82537"/>
        <property type="gene ID" value="SAMN04489712_102173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="149"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF82537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="34917" checksum="4C5EF4FFEFF8F4BB" modified="2017-01-18" version="1">MDMLNPVAGRFVRQANRFTEKITADGAEGLPAEPGRYRLFVSYACPWAHRTLIVRHLLGLQDVIDVAVVDPVRDEAGWRIPGGDPVTGATYLSELYLATDPSFEGRYTVPCIWDTVTRRLVTNDFPAITTMMETEFTAFHRAGAPDLYPAELRPEIDEINALVYDTVNNGVYKAGFAREQGPYEEAFDQLFATLDTLEDRLSRQRYLVGGQLTEADIRLYPTLVRFDSVYHGHFKCNLRRLVDYPHLWAYTRDLYSRPAFHETTDFDHIKRHYYMTHPHINPSRIVPKGPLLDWTAPHGRDRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V7Z4</accession>
    <name>A0A1H5V7Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82898">
        <property type="protein sequence ID" value="SEF82898"/>
        <property type="gene ID" value="SAMN04489712_102187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF82898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="11321" checksum="37E27D5D40C791F4" modified="2017-01-18" version="1">MSYPPEGCRYEVRYSLGRRGRSLESFPNEFALMEWFSEMTHLGMFDPLEFARPDEDGRNGYQIFCVTDQERVGISYFHPRLVRARIEAPRPTPERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VFV9</accession>
    <name>A0A1H5VFV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85698">
        <property type="protein sequence ID" value="SEF85698"/>
        <property type="gene ID" value="SAMN04489712_102290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF85698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="504" mass="51678" checksum="C331DB1009C2C7D8" modified="2017-01-18" version="1">MTSPGIRTGRHAPPKAPPAGGRQGIALLVIAMAQLMVVLDGTITNIALPSIQTDLGVSEANLAWIVNAYALAFGGLMLLGGKAGDLYGRRRVFRLGVAVFTAASLLGGFANGEAMLIAARVLQGVGAAVAAPTALSLIATTFPEGRPRNRAMGVYAAMSGLGATLGLLLGGTLTEYLDWRWVLFVNVPIGLAVLAGTGSLGEGERGHGRLDVPGALTGTTGMIALVYAITRGGEHGWGDRITLAGFACAAVLLAAFLALQARGRNPMLPLRLLRDRNRAGSYSAMLFIGAGMFATFYFLTLYMQLVLQYGAVETGLAYLPFSLGMGVSAGVGSQLASRVAPRTLAAPGLVVAAAGMGWLGTLTPDSSYTTALMPAMFVTAVGLGMSFVPMTLGAVSRVAEHETGIASALLNSAQQVGGALGLAALSTISTTAADDRLPHATERFFQGLAQHDFALVARAADALTHGYTRALWAAGACFAVALVITLTAVNAGRQEDAGKVAHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VGN0</accession>
    <name>A0A1H5VGN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative flippase GtrA (Transmembrane translocase of bactoprenol-linked glucose)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86364">
        <property type="protein sequence ID" value="SEF86364"/>
        <property type="gene ID" value="SAMN04489712_102314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF86364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="17207" checksum="75CAD2BD185ECFA7" modified="2017-01-18" version="1">MSARRRVPIRVPVRVREGVGFGGVGAVAFVITAGTGNALHAGLGLGPLTSTGLATVVATTFAYAANRAWTFRHRARSGLRREYVLFCWLNAVGLAITELVVGVVHYTLHLRGAVAYNAALVLGVGIATVFRFWSYRRWVFLERSAGSAEPAREREPAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VI41</accession>
    <name>A0A1H5VI41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR03083 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86999">
        <property type="protein sequence ID" value="SEF86999"/>
        <property type="gene ID" value="SAMN04489712_102334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="140"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF86999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="27195" checksum="B305226603F2A8DD" modified="2017-01-18" version="1">MGSLDVEQLMAGLLEETGALAETVRDADPDLPVPTCPGWSLRDLVEHVGNAHRWGATLVERRSAEPPPPETQRPQGPDWLREGAGLLVDAVRRTGAGTVVWTFLGPRPAAFWVRRMLHDTLVHRADATAAVGRKVGYRPELAADTISEGLELLSAPTSAQARPTLAELRGRGERLLLRPAEPAVRPGWMITRAPEGVRWERGDGPADVTLGGTVTELLLVFSRRLPPEKADVEITGDTALLDHWLARTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VK78</accession>
    <name>A0A1H5VK78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87679">
        <property type="protein sequence ID" value="SEF87679"/>
        <property type="gene ID" value="SAMN04489712_102352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF87679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="31541" checksum="09D0A18C2E8EBC59" modified="2017-01-18" version="1">MAVRAAEPSPLSLSMAGPAAEAAARICTVAGKLQRRMRLWAAEFPAPYDPDSFDPGLYSMLALAAAFSEPRRTVDELQPAGRVRLWTLGLARCAARAASESEVRRIAEHCAAVADGAAPAPGDDLARFLAAIRDELSELPTYPVLHEVWRDELRRTLQALSRNRAALGRRPTFEEYLDNADCLGLALTFTAHRIAIGDTGPGEEPTDAARAVQRAVRLSGDLGAAARRVDPGEPNALTLGLPRPALELRLAELTGQARRLIAAARVRHPEQADHLERHMDFYAGFFGTTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VPJ9</accession>
    <name>A0A1H5VPJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03083 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89229">
        <property type="protein sequence ID" value="SEF89229"/>
        <property type="gene ID" value="SAMN04489712_102407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF89229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="29030" checksum="DE00A62A4E1302E8" modified="2017-01-18" version="1">MRDDMARNAAAWEQTLRSTIALAGDFDASHYDLSTDCPGWTVKDVLSHLISVERMLLGEALPEHPLPDDLPHVRNDFGRLLEIGVDVRRPVPGEQVLAELAEVLDLRLAALPGIDPEQPTTLPTGATGTYALFMEFRAFDCYVHEQDIRRAVNRPGNLDAPAAQCARARLAPGLPYVFAKRAGARPGQSLRLEVTGPAAFTAYIAVAEDGKARETEPVPDPTVTLRMDWESYLKLASGRCTPESVAVTTTGDTTLATRILTNMAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VSY1</accession>
    <name>A0A1H5VSY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase/pyrazinamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90419">
        <property type="protein sequence ID" value="SEF90419"/>
        <property type="gene ID" value="SAMN04489712_102448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF90419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="20146" checksum="AFD3296E747ED943" modified="2017-01-18" version="1">MGRALVIVDVQNDFCEGGSLAVGGGADVASAISRHLAEHRGEYDHVVATRDFHLDPGAHFSDEPDYVNTWPPHCVIGTPGADFHPNLTLAPIEAVFSKGRSKAAYSGFEGVCDAGASLGDWLREHGVEEVDLVGIATDHCVRATAVDAARAGLRTRVLLDLTAGVAAPTTERALAQLRDEGVELAGTPVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W049</accession>
    <name>A0A1H5W049_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92658">
        <property type="protein sequence ID" value="SEF92658"/>
        <property type="gene ID" value="SAMN04489712_102532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF92658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="24192" checksum="3CABC07B7298321E" modified="2017-01-18" version="1">MIRAVVFDVGECLVNETREYGTWADWLGVPRHTFSAVFGAVIARGLDYRETFQVFAPGFDLTEQREKRAEVGQAEWFGEDDLYPDARPALAELQEAGLWVGIAGNQTVRAGGILRDLKLPCDMLATSDDWGVAKPDPAFFGAVVREAPCEAGEILYVGDRLDNDIRPAVAVGLQTALIRRGPWGIIQQDDPEADRLPTMRIDSLTELPGRIAEFNASER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W1C4</accession>
    <name>A0A1H5W1C4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_102554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93302">
        <property type="protein sequence ID" value="SEF93302"/>
        <property type="gene ID" value="SAMN04489712_102554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="14"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF93302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="469" mass="50848" checksum="5A3407A7DA1C83C7" modified="2017-01-18" version="1">MAQGQQGHLLGNRYRLDTVVGRGGMGTVWQAYDTMLDREVAVKEVLLPPGLSPADRDVLYERTFREARASARLNHSSVVTVHDVLNEGGRPWLVMEFVRARSLQDLIDEGPVPPRRAAEIGRQTLDALRHAHGKGILHRDVKPSNVLITDEGRAVLTDFGIAQVEGDATLTQTGLVMGSPAYIPPERAQGERAVPASDLWALGATLYAAVEGRSPYERSDAMASLAAVLSEPVPPPRNAGPLRDVLMGLLAREPRYRLTADQALPRLAEVAGMPEARTGTPPQVREFRTVLDETKLDEPFERPAARPLGRSAQRPADRPAERPPNRPAHRPSVGYGPPPPLPPQAGETVLDSAEMETTTRDDTGPESRPRHTPPQHDAEARTVVQTDWTPPPPYNPAQWQQRPQQPQRSRSQDRYERERTRTIVIVAVAVILVVIAVLAGALILRERTGAAGPSGGAGTGTAAVTAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WEK0</accession>
    <name>A0A1H5WEK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03089 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97788">
        <property type="protein sequence ID" value="SEF97788"/>
        <property type="gene ID" value="SAMN04489712_102690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF97788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="294" mass="30893" checksum="2B289A2E62A405F5" modified="2017-01-18" version="1">MADNGLAELLAGRLAEDPSRPLVTFYDDATGERVELSGRTFANWVAKTANLLVDGLGAQPGDRAVLVLPPHWQTAVWLMACWSAGLVAEPVEPDRVGELVNGVVDGVEPDGGRGPYLLVAAEEVLSLPGWYDAHAADAEEVVGLSLHALGGPLGDHPAEILDYAVEVRGYGDRFVSYAPVDVTAPVLRVAEETPATNVTFATLTAGELTSRSAAAAHDWGLDARSRVLTDLPFTTLGGLLVGLVAPLAAGSSVIIQRNLDEAVLNRRISLEHVTAVAGVHGWDDASGSVRRLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WZL8</accession>
    <name>A0A1H5WZL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphotriesterase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="2">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04898">
        <property type="protein sequence ID" value="SEG04898"/>
        <property type="gene ID" value="SAMN04489712_10326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG04898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="35483" checksum="944F4E0C796F11DD" modified="2017-01-18" version="1">MTAVETVTGAVDVAELGRTYMHEHVFVLSSEHVQNYGAGAWWDEEERIADAVTKLRGLVAHGVTTIADPTVWGLGRYIPRVRRIAEQVPELNIIVATGLYTYDDLPFQFHYRGPDTLLGGPDPLVEMFTRDIVEGIADTGVKAAFLKCCVEAQGLTPGVTRVLRAVAAVHRETGAPITVHTSAGAQSGRLAVGLLGEEGVDLSKVVIGHAGDSNDLDYLMELADTGAILGMDRFGLDVYNPTAQRVATVAALCERGYADRMVLSHDASCYMDWFGPDPESLRGMVPNWHYEHIGDDVLPALRALGVTDAQFDQMLVGNPRRYFSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X1Y5</accession>
    <name>A0A1H5X1Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein CpaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05385">
        <property type="protein sequence ID" value="SEG05385"/>
        <property type="gene ID" value="SAMN04489712_10342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="137"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG05385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="42217" checksum="14A39F799EF5B0AB" modified="2017-01-18" version="1">MPIICEPDEGAARRLAVGFREHGHAVKDLETLERTLAARPDELIVVFGPGAPLEGVLAFAAGRRIDRPVLGVVLVRTVLEVNTLAQAMRAGIREVVPDRDFPALMEACKRCWEVSARLRATEQAQPSEGAPEPGRDGKVVVLFAGKGGCGKSMLSTNLAVALAGRGREVCLVDLDLAFGDVGIMLQLSPQRTIVDAVPMGGHLDQTGIRSMLARHESGACAVLAPVAPGDAEKITGRLVTDLLAVLRRMFDVVVVDTPSQFSEPVLAALDAADRHLLLVGPEVTALKALRVTLDMLDLLGYPASTRQVVLNRADARAGLSRSDIDRVAGRPIGVRVPSSPDVPASINKGVPLAMAHPGHQVSRAVQEVADLVLEEDRRTAGRGRRRGGLRRAKAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X4Z8</accession>
    <name>A0A1H5X4Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06346">
        <property type="protein sequence ID" value="SEG06346"/>
        <property type="gene ID" value="SAMN04489712_10374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG06346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="16219" checksum="3CAED7436BE2F463" modified="2017-01-18" version="1">MSGEQAERDRHWLELACDLARLCPPSRTAFSVGAVIVGADGTELSRGFSRESDPKAHAEEAALAKPMEPADLGGATIYSSLEPCGRRLSRPRPCARLIVDAGIGRVVYAWREPSLFVEGDGEEVLRAAGIEVVWIGDLAERAREPNAHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X5H3</accession>
    <name>A0A1H5X5H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06526">
        <property type="protein sequence ID" value="SEG06526"/>
        <property type="gene ID" value="SAMN04489712_10380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG06526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="19116" checksum="F53ED6C7DC6B6A94" modified="2017-01-18" version="1">MTQVDPQVLARARARITGPVAFPAAEPVPAGLTRVAAGERVWALPAWPDGATPAVLEEYQTLPMPLDRPGQARRVLAAALRCCWTRLDDAPWPGRAAALTDVLELYATTTRGDAELMRRWAVGDLRRLADTGWLLLDEEAGTVRPGPRTALWAEESLAPLRALLRRMPPPPGGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X642</accession>
    <name>A0A1H5X642_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-myo-inositol dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06850">
        <property type="protein sequence ID" value="SEG06850"/>
        <property type="gene ID" value="SAMN04489712_10391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG06850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="31214" checksum="E07376A5A03DB25B" modified="2017-01-18" version="1">MGSLMERVAGAPISWGVCEVPGWGLWMSAGRILGEMRDLGLQATELGPQGFLPADPRRRAQMLRAYGLVLAGGFVPMVLHDPAHDPLPEADRAMDALGEGTPLVLAAATGLDGYDERPDLGTKNWVTLMANLDAVAARATERGHVAALHPHMGTVVQGRQEVERVLDGSGVPLCLDTGHLFIGGADLQFLARTVPDRIAHVHLKDVDADLAARVRDGALTYTEGVRSGMYRPLGHGAIDIARLVATLEDAGYEGWYVMEQDTIIDTEPPAGAGPAVEVEAGLRLLREVADGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XDW6</accession>
    <name>A0A1H5XDW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferredoxin--NADP+ reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_103212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09961">
        <property type="protein sequence ID" value="SEG09961"/>
        <property type="gene ID" value="SAMN04489712_103212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG09961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="452" mass="49254" checksum="D224666560F71A6A" modified="2017-01-18" version="1">MARMVDTRVAVIGSGPAGLYAAEALVKQTGGDVQVDVLDRLPTPYGLVRYGVAPDHKSIKSIAKYLQRVLEHPAVRFFGCVELGRDVTRAELLDCYDAVIYSTGAMVDRHLGIPGEDLPGSVAATDFVNWYCGHPDAADHAFDLSVEEVAVIGVGNVAVDVVRVLAKTAEELRETDVPEHVIEALAASKVRRIHLIGRRGPAQAKFTTKEARELGELANAEIHVRPEDMELDAASAELAETDRLVRGNVKVLRSWTEPPAGAKPRRIDVRFWLAPAEILGTRQVEGLRLERTALDADGRVRGTGSYETLPVGMVLRSVGYQSVPLAGVPFDERNHVVPNEGGRVIDASGAQVPREYVAGWIKRGPTGVVGTNKSDAAETVTHLLADLAAGDDRPRPRQRVEDLLESRACRVVTYSDWLNLDTAEIDLARSLGRGERVKLGRWEAMRTACHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XK82</accession>
    <name>A0A1H5XK82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trk system potassium uptake protein TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11636">
        <property type="protein sequence ID" value="SEG11636"/>
        <property type="gene ID" value="SAMN04489712_103275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="137"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG11636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23609" checksum="E2C7050187BE2B64" modified="2017-01-18" version="1">MRVAIAGAGAVGRSIAQELLENGHEVLLIDKDPRAIKVEVVPRAEWLLADACEIASLDDAALERCQVVVASSGDDKVNLVVSLLAKTEYGVPRVVARINHPKNEWLFNESWGVDVAVSTPRLLSALVEEAVSVGDLVRLMTFRQGEANLVELTLPEDAPLGGQRVGSVTWPTDTALVAILREGRVLVPTPDDTLEAGDELLFVANQDMEDELAELLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XMR3</accession>
    <name>A0A1H5XMR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12670">
        <property type="protein sequence ID" value="SEG12670"/>
        <property type="gene ID" value="SAMN04489712_103311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045684">
        <property type="entry name" value="DUF6191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19690">
        <property type="entry name" value="DUF6191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG12670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="14790" checksum="FA8795CD5F2BA5E8" modified="2017-01-18" version="1">MKSPFRRRRRPKGRAAKPRTVEPEVVDWPSGGTGRTSMMGAIRGDGETGAGFGAGMFEDLHAAFSGAKKIQLQEQEAQRLRRGDDHHVEGDGKARDDLDSGKIRIRRAGPAAAAAGPEGQAASEGPDGAAEPGSGETGSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XWW3</accession>
    <name>A0A1H5XWW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16133">
        <property type="protein sequence ID" value="SEG16133"/>
        <property type="gene ID" value="SAMN04489712_103444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026335">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04269">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="30"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG16133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="415" mass="46297" checksum="8A11B89269EF6CEA" modified="2017-01-18" version="1">MTAVADPASAAAEWPARLDVQALLESGWRPTPFHQFVLKIHSRCNLACDYCYMYEMADQSWRRQPRRMSRPTLDRVALRIAEHARVNRLPGVEVILHGGEPLLAGPDHIRYAVDTIRSAVDPDIQVSFHLQTNGTLLDSVFLQLFDELGVFVSVSLDGDEEGHDRHRRRANGRGSHATVTTGLRRLTAPAYRHLFSGLLSTIDLDNDPVATYEALLRFRPPTVHFLLPHGNWDNPPPGRVPGSDAASYGDWLIEVFDRWYRAPVRETRVRMFSEIIRLLVGRPSRSESIGLSPVAVAVVETNGGIEQVDTLKSAYEGATSTPLHVSRDSFDTALLLPRIAARQIGRRALAAECRSCPLQRVCGGGLYTHRYRSGSGFANPSVYCPDLFRLISHIQRTVTKDLAALKHSSRKRGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZ74</accession>
    <name>A0A1H5XZ74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type VII secretion AAA-ATPase EccA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16650">
        <property type="protein sequence ID" value="SEG16650"/>
        <property type="gene ID" value="SAMN04489712_103467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="305"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="597"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG16650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="834" mass="89201" checksum="4AE2DBDD13293593" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZV6</accession>
    <name>A0A1H5XZV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17152">
        <property type="protein sequence ID" value="SEG17152"/>
        <property type="gene ID" value="SAMN04489712_103486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="73"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG17152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="15440" checksum="A4A34363C0A97BB8" modified="2017-01-18" version="1">MTTARDVMHSGVQCISESETLDRAAQMMRDMDVGALPICGADDRLHGIITDRDIVVKCIAAGHDPSKATAGELAEGTPRWVEASADISEVLREMLEHRIKRLPVIENKRLVGMISEADLGQKLPEDQIAEFVEKVFVPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YPJ6</accession>
    <name>A0A1H5YPJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PepX_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25612">
        <property type="protein sequence ID" value="SEG25612"/>
        <property type="gene ID" value="SAMN04489712_104101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="306"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG25612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="556" mass="59816" checksum="578494C902923B49" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXZ0</accession>
    <name>A0A1H5YXZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29093">
        <property type="protein sequence ID" value="SEG29093"/>
        <property type="gene ID" value="SAMN04489712_104252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031423">
        <property type="entry name" value="Phosphatase_SCO2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15698">
        <property type="entry name" value="Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG29093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="28419" checksum="2A386A44DCE94060" modified="2017-01-18" version="1">MIAGEVATPRQNNLLHYRRMAAGNPYYRFGLDLKRQWTERDVLEMMVELCGVVPDRAHLYGDDTIDPDKTIGALERMAERIGQAARRRERVVLATGHPATLMPIYLAVGQALRERGCTVLTPAAGWAYQAEVGAGASQRRQIRYHEGMVAALDGDDGRAHHTHDAFPMEAMLAELAANPTALDGSSAGDSKNWPDLAIADHGWAGAAGQAGIDTVGFADCNDPALFAGEVEGRILVTVPLDDGVLPAYYAPLTAYLMSHAGLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YYU1</accession>
    <name>A0A1H5YYU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell envelope-related function transcriptional attenuator common domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28970">
        <property type="protein sequence ID" value="SEG28970"/>
        <property type="gene ID" value="SAMN04489712_104246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="137"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG28970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="384" mass="41461" checksum="BBABF16996BE8BED" modified="2017-01-18" version="1">MRDADCKLRAMSTRSPQESSASAGPSGDGPDTGEGTAIAEPPEQAARARRRQRRRRVLLAVLVFVVLIALGLGGLLWQRQASYNGNIDRLPGTMPTGPRPGPNVVGTENWLLVGSDTRVEAHTTGEGGQLWKPGQQRSDTLMLLHLPAERDKAYVISIPRDSWVPVPGYGTQKINAAFSYGGPPLLIQTVESLTGVRIDHFGAIDFNGFKDMTDALGGVDVHIAETVSDPKNNITWQAGKNHLDGDKALLFVRQRYNLPNGDFDRIKRQQAFLRAVTQKAAEGGTVTNPLKLDRFLSAFTKSISVDESVSAGDLRSLALSMRNVRGSDITFMTVPNKGPAARGRQSVVLLDDAKAKLLYEAVRGAEVAEYVKEHGGANSVGKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z0H2</accession>
    <name>A0A1H5Z0H2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_104245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28946">
        <property type="protein sequence ID" value="SEG28946"/>
        <property type="gene ID" value="SAMN04489712_104245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="8"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG28946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="244" mass="25742" checksum="6919C6D634F17A33" modified="2017-01-18" version="1">MSVGVTLATTRRILSQLRHDHRTVGLIVGVPSLLMILLRYVLDQPGMFDRVGPMLLGVFPLIIMFVVTSVGTLRERSGGTLERLMTMPLGKLDLLLGYALAFGLVSLLQVGVVLALSLTWLDLDLAGPVGVLVAAAVLCALLGVALGLLASAFARTEFQAVQLMPAFVLPQALLCGLFVPRDQMAGWLEAISAVLPLSYAVEAMQQVTQESGVTGTLLADIAVIAGCTLLALGLGAATLRRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z9H1</accession>
    <name>A0A1H5Z9H1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">SAMN04489712_104421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32680">
        <property type="protein sequence ID" value="SEG32680"/>
        <property type="gene ID" value="SAMN04489712_104421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="91"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG32680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="20018" checksum="27784F7BC2789788" modified="2017-01-18" version="1">MSRIGRLPIAVPSGVDISIDGQAVTVKGPKGELKHTVAEPIEVKLEDGNVTVARPNDVNTVRALHGLTRTLIANMVEGVTKGYSKTLEVRGVGYTAAAKGSDQVELKLGYSHPITYKAPEGITLRVETVRRDQINALIHVDGIDKQKVGEVAANIRKFRKPDVYKGKGVRYQGEQVRKKVGKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZCB4</accession>
    <name>A0A1H5ZCB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_104476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33941">
        <property type="protein sequence ID" value="SEG33941"/>
        <property type="gene ID" value="SAMN04489712_104476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG33941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="21615" checksum="1355FFDE959ABB98" modified="2017-01-18" version="1">MTSEARALRTAARPDEGDLGDLTTLAVQGDPGAIEVLLAQVRPMVVRYCRARLGRISGQYHIADDVAQEVCIAVLSALPRYRDMGRPFASFVFGIAAHKIADALRSAVRAAVPTEDLPDGPDDRPGPEETVVRYIEAERARDLLTRLPDHQRELVLLRVVAGLSAEETGNVLGMTAGAVRVAQHRALARLRAMASEESIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZDF1</accession>
    <name>A0A1H5ZDF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_104466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33687">
        <property type="protein sequence ID" value="SEG33687"/>
        <property type="gene ID" value="SAMN04489712_104466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="157" mass="16216" checksum="8EF518C0069E38E4" modified="2017-01-18" version="1">MSGPVTLPVATADDMRGLGIRLAGLLRPGDLLVLSGDLGAGKTTLTQGLGEGLKVRGPITSPTFVIARVHPSLGGGPALVHVDAYRLGGFAELDDLDLDASLPDSVTVVEWGEGLAENLSEERLEVVIIRGDTDTEERTVKVAGIGPRWAGLAEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZW83</accession>
    <name>A0A1H5ZW83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG39957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG39957">
        <property type="protein sequence ID" value="SEG39957"/>
        <property type="gene ID" value="SAMN04489712_1058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="90"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG39957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="377" mass="41827" checksum="24BEB03964329984" modified="2017-01-18" version="1">MKFRHAQEEPNPQDEALRRGLGLSRRQLLAATTGIAAAAVAVPALPGRAAATETPLIRDSKRGIILYTVRDAISRDPRTTNLPSGFRQVFEALSKIGFERVEFAGYTQHAASEGGANLETVEGARLLRSWLDDNGLRAEGNHGFIPSSWPLSQSDLDRFKRTLEIANILGLDHMGTGSDPTNSAYKADWDVAAEKWNKLGEIARAAGYTKLYTHNHDAAYNFLLDSGPLDAQGRPTRSSGIRRLEYFLQITDPKYVYLELDIYWAHVAQYKFKTYTAPDGSVQTKIFDPLAVVKPNERRFPLFHAKDGKLNPANGNGYDMVPFGTGDIDYARFFGSLESQHHYPMYEQDNAPGGTANPAQSLQFAELSYKNLSDLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A728</accession>
    <name>A0A1H6A728_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="6" type="ORF">SAMN04489712_105235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44140">
        <property type="protein sequence ID" value="SEG44140"/>
        <property type="gene ID" value="SAMN04489712_105235"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
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            <begin position="228"/>
            <end position="230"/>
        </location>
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        </location>
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            <position position="18"/>
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            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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        </ligand>
    </feature>
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        <location>
            <position position="130"/>
        </location>
        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
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        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG44140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="34776" checksum="133FEA63E4E5FECB" modified="2017-01-18" version="1">MTSTTDRRVLLAKPRGYCAGVDRAVQAVEIALEKYGSPIYVRKQIVHNVHVVKTLEERGAVFVDETEEVPEGAIVVFSAHGVAPVVHEEARGRSLRTIDATCPLVTKVHKEAVRFAADDYDILLIGHEGHEEVIGTSGEAPDHIHLVDGPGDVAGVQVRDPDKVAWLSQTTLSVDETMATVAALRERFPNLIDPPSDDICYATQNRQTAVKQIAAQAELVIVVGSTNSSNSVRLVEVAKEYGADAAHLVDYADQIDPAWLEGVTTVGLTSGASVPEVLVRGVLQWLAERGYDRVEEVESVPESMRFALPHELRKDLRAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABF5</accession>
    <name>A0A1H6ABF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="SEG46089">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292506" evidence="1">
        <location>
            <begin position="26"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="99"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="SEG46089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="34508" checksum="7F22C660C18072C1" modified="2017-01-18" version="1">MRKVLVFGTALAAASLSTVAVPAEAHTEPGPAVNAPVTPGRGTVQTNPGGGVGVTARAVMVTPLPPKTATYSYGKGARQKLDAYWRDSGPDDAAPRPAVLILHGGYWMSGDKGSWRYMARRLVTRGYVVFSANYRLIPSSRWPSQREDVEAALDYIRSHAHRWNLDPSRIVVLGSSAGGHLATQLGTYGEGARRVRGVVALSPVVSPSQAYQDGGLAGADYPRVKLRHAVQMLVGCSPDEGAPECLDRLEDASSAAHAGAGDAPMLLVHSAEEFVPVSHSEGLAEALRAAGVPVTVRTVPGDAHGGTLLNDERLRESVIAWIDSVAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AID1</accession>
    <name>A0A1H6AID1_9ACTN</name>
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        <name type="scientific">Thermomonospora echinospora</name>
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                <person name="Submissions S."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="25"/>
            <end position="47"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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        </location>
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        </location>
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        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG47847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="725" mass="75913" checksum="10B6E24F544B383C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AKE9</accession>
    <name>A0A1H6AKE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49223">
        <property type="protein sequence ID" value="SEG49223"/>
        <property type="gene ID" value="SAMN04489712_105521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046196">
        <property type="entry name" value="DUF6228"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19739">
        <property type="entry name" value="DUF6228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG49223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="15931" checksum="7542F6DF870F6D6F" modified="2017-01-18" version="1">MIDEEDRFVIPSSGSTPRWVVHRPIDPYGEGYVHTMLVELSDEGLTASGHATFEGRTPENLQDFLLGLAKDWRGWPGVRSWTSMDGEMTLEAGHDGRAYVSIAVTLRDCPHDPGGWSARIVLSLEAGEELRRLADTAERFLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AKX3</accession>
    <name>A0A1H6AKX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48396">
        <property type="protein sequence ID" value="SEG48396"/>
        <property type="gene ID" value="SAMN04489712_105473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="34"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG48396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="175" mass="19270" checksum="C95C7A944F8CB840" modified="2017-01-18" version="1">MSVLPTERRTPMPPARFRSHPHDPDRDREELHLAALPSAAGHARRFVRARLHKWDLDRLAEACELVASELVTNAVTATGSRTIPSGHTALHDRTPAVIVLQLRLTRHRLVCEVWDSSPLPPVPTTVPGLLDENGRGLFLVAAYAMGWNSYSSPAGGKVVLAWWNPWATDRALVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B076</accession>
    <name>A0A1H6B076_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trypsin-like peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53980">
        <property type="protein sequence ID" value="SEG53980"/>
        <property type="gene ID" value="SAMN04489712_106129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045453">
        <property type="entry name" value="VMAP-M8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045450">
        <property type="entry name" value="VMAP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20028">
        <property type="entry name" value="VMAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19969">
        <property type="entry name" value="VMAP-M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VMAP-M8" evidence="1">
        <location>
            <begin position="199"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="VMAP-C" evidence="2">
        <location>
            <begin position="341"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG53980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="568" mass="63284" checksum="4288C0710AAFA203" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B0Q7</accession>
    <name>A0A1H6B0Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54224">
        <property type="protein sequence ID" value="SEG54224"/>
        <property type="gene ID" value="SAMN04489712_106144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="304"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG54224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="408" mass="43344" checksum="5E38C334979AE7D5" modified="2017-01-18" version="1">MSASPPLLKRIPPGLWAALAWFTAAVEPIVQYVLMPPRHRYSLDYPRDGLDSFTAKALLACAFVMVLAGSALLRRRTLPAYGLLVAGTVVSTLAWRQDEIPPLQFLGVDVALCYVAATRPRRDSLAAAAGALGVLAGCFVLREVTGYGSGTAPEPYVSLTVVIAWLIGNSVAQARVHTEELHAQAAAQAVTAERLRIAREMHDTVAHSIGIIALQAGAAARVMETQPARAREAMLTVERTGRETLSGLRRMLGALREADQDGRRTPPHPTTGLADVARLAATTTAAGVRVEVHWEGRHRPLPPDIDLAAFRIVQESVTNVVRHSGAGSCRVSIGHREDALVIEVRDHGRGGGTGTDTGYGLAGMRERVALLHGDFTAGPQPQGGFLVTARLPLPEAAAPEPEAKAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6J3</accession>
    <name>A0A1H6B6J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55837">
        <property type="protein sequence ID" value="SEG55837"/>
        <property type="gene ID" value="SAMN04489712_106263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="22361" checksum="66AC2F82FF7EEAB2" modified="2017-01-18" version="1">MPQGRPEHVPDDGLTTRQRRNRPLVIVHTGQGKGKSTAAFGLALRAWNQGWPIGVFQFVKSAKWRIGEETALRVLGESGQGGTVSWNKMGEGWSWIQRPGTEADHAADAREGWAQIRRDLAAETYRLYVLDEFTYPIKWGWIDVAEVIETLAARPGAQHVVITGRDAHPDLVDFADLVTEMGKVKHPMDRGQKGQKGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BY80</accession>
    <name>A0A1H6BY80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65612">
        <property type="protein sequence ID" value="SEG65612"/>
        <property type="gene ID" value="SAMN04489712_108120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG65612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="322" mass="35358" checksum="1F3DCB363C341C57" modified="2017-01-18" version="1">MTSRSGGGRVELAVYRQGDPGRPVVLLVHGYPDTHAVWDEVAASLAGRFHVVRYDVRGAGASARPFGTAPYALEHLMADLRAVLDEVSPGRPVHLVGHDWGSIQGWEAVCTMPTRFASFTSISGPCLDHVGRWMRARLARPTPRNLGLAAGQALRSWYIYLFQTPVLPELLWQAGLGGPFGQALRLGEGVEPREGHPARTLARDAAAGVGLYRANMRERLRHPRDRRTDVPVQVIVPTRDMFVSPHLVGGLGERVPDLSLRTIDARHWVPRSHPDVIARWVGEHVTRVEGGPLTAAESRALERARVRPPTARAARPRPSRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYZ4</accession>
    <name>A0A1H6BYZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65929">
        <property type="protein sequence ID" value="SEG65929"/>
        <property type="gene ID" value="SAMN04489712_108150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="162"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="302"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG65929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="43089" checksum="6EA6E46D3E37BF50" modified="2017-01-18" version="1">MPYRTLRGGHAPIRMWADPADVEEAALGQLRNVAELPWVEGVAVMPDVHHGKGATVGSVIAMRDAVSPAAVGVDIGCGMTAVRSSLTVEDLPDDLGGLRSRLEKAIPVGRSAHKTPVDPSAVPGLRERGWYEFWKGFEELIPSVRGRLGRARAQMGTLGGGNHFLEVCADDAGSIWIVLHSGSRNIGKELADRHIEAARKLPHNQDLPDPDLAVFLSGTAKMDAYRRDLFWAQEYARRNRTLMMALAQNAVTRFFSGRKVTWDDHISCHHNYVATEVYDGVELLVTRKGAIRAGAGDLGIIPGSMATGTYIVRGLGNREAFNSASHGAGRRMSRNKARKTFTLADLEAQTQGVECRKDAGVIDEIPGAYKDLEAVMAAQSDLVEVEAHLRQLVCVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C303</accession>
    <name>A0A1H6C303_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized domain 1-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67328">
        <property type="protein sequence ID" value="SEG67328"/>
        <property type="gene ID" value="SAMN04489712_108277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="65"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG67328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="17311" checksum="BC638CE6E9CEA4BE" modified="2017-01-18" version="1">MSDAAELRDDTTRVADLPEDQREYIRSMFQAAPLSALLDLRLVEMSPRHAVVCMPIGAQASNSSGRLHGGAIATLIDQAAGTAAAHAGGLDMTTHALVTVDLHVRYLARARGERVYARAEVLKVGSRLITIECKVTDDDGRLIASSDFGMMIVPRHDAGGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8B6</accession>
    <name>A0A1H6C8B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69219">
        <property type="protein sequence ID" value="SEG69219"/>
        <property type="gene ID" value="SAMN04489712_10962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="27961" checksum="467C424D92E48C16" modified="2017-01-18" version="1">MFWRKTKAAIGNFHPLHQGLIWQRGLSAAMRPADWAALVQSLAGHDAVVKRRKWAPPHRTHHVLVPLIRVLSQDMRPDGVLAITADLRGPDFPEKLTPQRDLAVQRPIRSIKEWYSIDPWLRIRAELRDGSVLDLSVTDRVRYRKIHKVVRGKHKTKQKTKVVQQVTATRRLRRDAPVRQPAVPPPSWLRVRVRNDRRMVIRTSAKFPKDDAQLSERILYVLTEAFRWTPPGLARPARRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9K1</accession>
    <name>A0A1H6C9K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69588">
        <property type="protein sequence ID" value="SEG69588"/>
        <property type="gene ID" value="SAMN04489712_10999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294644" evidence="2">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG69588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="22218" checksum="27D961088F3FA2F4" modified="2017-01-18" version="1">MLKRLATAGILTAAVGGMLMSATPAMAGDRDHGRNKGRHHGHSHSRHHNGKVRNPGHHHKAPARGKKKAHGRPNDGYNRPDEGYGYGRPDEGYGSNRPDDRYGSNEPGYDNDALYGDSDGLYGDDDLYGDDDYGFRRIGDRDKYKNHDNVLVNKCDIHQGNEYSLVDLDVIKDVAILALGSGNDVYKAECDQANVIYNKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCW2</accession>
    <name>A0A1H6CCW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crotonyl-CoA carboxylase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70738">
        <property type="protein sequence ID" value="SEG70738"/>
        <property type="gene ID" value="SAMN04489712_109198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043880">
        <property type="term" value="F:crotonyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010085">
        <property type="entry name" value="Crot_CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01751">
        <property type="entry name" value="crot-CoA-red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="46"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="435" mass="48179" checksum="F82F1869C025A6D3" modified="2017-01-18" version="1">MSELLDAVRSGASPAELLDCEVPTRFQAAYTRLDEIGIFEGETDKDVRRSIHVGEVDMPELAPDEALVAVMSAAVNFNSVWTAIFEPIPTFYFLNKLGQRDRRHELPYHVFGSDAAGVVVRTGSMVRHYKVGDKVVVSPAIVDDQDPIIQEDGVLTHEPLAWGYENNYGAFGQYCIVKAHQLMPKPAHLSWEESAANTLCAGTAYRMLIGGHGARMKMGDVVLVWGATGGLGSYAVQLVKQAGGIPVAVVSSEEKAELVRRQGCEHVLNRSEIDFGDRGMNHPKAWRRLGEEIRRLTGEDPHIVFEYLGRETFGASTYVARRGGKVVTCGSSTGYRHEYDNRYLWMNVKSIVGSHGFNYQEAIETNRLFQLGMLYPTLSKVYPMEQTAEAVRAVQTNNHIGKVGVLVGATAEHQGIDDPAARERFGEDMITLYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CD59</accession>
    <name>A0A1H6CD59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_109210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70838">
        <property type="protein sequence ID" value="SEG70838"/>
        <property type="gene ID" value="SAMN04489712_109210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG70838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="27010" checksum="315453A1C513D93D" modified="2017-01-18" version="1">MAEAVRSLERAFELLEHLADAGGEMALSELTDRSGLPMPTIYRLMRTMVNQGYVRQEPSKRYALGPRLIRLGESATRLLGTWARPALARLVDEVGETANMAVLEGDAAVYVAQVPSRHSMRMFTEVGRRVQPHCTGVGKALLAQLPAETVREIIGRTGMAAHTPHTITDPDTLLTELARIREQGYAIDDEEQEVGVRCVAVPLPGAPTPAAISVSGPSGRLTREMVTDVVPLMHRTAEHFARDLTPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDQ1</accession>
    <name>A0A1H6CDQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of protease activity HflC, stomatin/prohibitin superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71084">
        <property type="protein sequence ID" value="SEG71084"/>
        <property type="gene ID" value="SAMN04489712_109239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG71084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="38337" checksum="79E4899A2F4F9C46" modified="2017-01-18" version="1">MAAVITGLVIALVVLIVMLRTVRIVPQARAGNVERLGRYLRTLEAGLNFVIPFVDRVRPLIDLREQVVSFKPQPVITEDNLVVHIDTVQYFQVTDPRAAQYEIADYIQAIEQLTITTLRNVIGSMDLEATLTSREKISTQLRAVLDEASGKWGVRVNRVEIKAIDPPPTIKEAMEKQMRAERDKRAAILTAEGTRQSAILTAEGEKQSAILRAEGAKAAAVLEAEGQSQAIGRVFSAIHRYNADPKLLAYQYLQMLPELAKGQGNTFFVIPSEVTSALQAVSKAFGGSIEEATRIPDEPTEAPEHAEPVQHLDEEEMSKPNGPAELTAPAPEVPAAYETAPEQARDTAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CE31</accession>
    <name>A0A1H6CE31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Poly-gamma-glutamate synthesis protein (Capsule biosynthesis protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71047">
        <property type="protein sequence ID" value="SEG71047"/>
        <property type="gene ID" value="SAMN04489712_109235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294761" evidence="2">
        <location>
            <begin position="31"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="3">
        <location>
            <begin position="46"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG71047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="360" mass="37348" checksum="1A1930631E04E107" modified="2017-01-18" version="1">MGRRLRAAMTGAAATAAMTLVTGCGPLSLAIDDSTGHSAENAGPVTVAFGGDVHFEGQIRARLDADPRTALGPVAKQLSAADLAMVNLETAVTTGGTPAPKQFVFRTPPTAFTALEAAGVDVATMANNHGMDYGETGLRDSLAAAKQAKFPVVGIGNNAAEAYRPWGTVVGATKVGVIGATQVLDDNLIEAWTATDAKPGLASAKNAQRLVQEVQRARKDYDVLIVNLHWGQELNKCATDAQKQLADQLITAGADAVIGSHAHVLQAGGYLKGKYVHYGLGNFVFYNSGPTTGQTGVLTLTFTPPAGHKRESGAKVTKSHWAPAFINGGIPQPLTGAEAQQARTQWEGLRSCANVTANPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJY7</accession>
    <name>A0A1H6CJY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73301">
        <property type="protein sequence ID" value="SEG73301"/>
        <property type="gene ID" value="SAMN04489712_11094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021426">
        <property type="entry name" value="DUF3073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11273">
        <property type="entry name" value="DUF3073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="72" mass="8078" checksum="2DBD902CD63F6A07" modified="2017-01-18" version="1">MGRGRAKAKQVKVARRLKYNSGGTDLDRLKEELGVPSSNHDPYDDSYDDLVEKYSDFADDDADDRESGKPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKC6</accession>
    <name>A0A1H6CKC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73207">
        <property type="protein sequence ID" value="SEG73207"/>
        <property type="gene ID" value="SAMN04489712_11083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="496"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="663"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG73207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="754" mass="78227" checksum="4225B55C0A696330" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRI0</accession>
    <name>A0A1H6CRI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75591">
        <property type="protein sequence ID" value="SEG75591"/>
        <property type="gene ID" value="SAMN04489712_11160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="51" mass="4920" checksum="F145FA1F835F0CE7" modified="2017-01-18" version="1">MNGGLVGLLVGGTVGVLWGAVSGTGVIGNALLGTLVGSWLGLVVLSKRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSC8</accession>
    <name>A0A1H6CSC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75891">
        <property type="protein sequence ID" value="SEG75891"/>
        <property type="gene ID" value="SAMN04489712_11195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="129" mass="13707" checksum="88D27FAD48C0074C" modified="2017-01-18" version="1">MTESTTEPAGGPVDAACGPDDGAAECGPAAVQLGPGAREFLKALASEQRQQMLELFAGGIELTVGTVAERLGIAQPTASQQLALLRRVGLLTSRKDGKQVHYRIDATAVERSLSELQNYLRTCCPPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUZ0</accession>
    <name>A0A1H6CUZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76335">
        <property type="protein sequence ID" value="SEG76335"/>
        <property type="gene ID" value="SAMN04489712_111151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="154"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="295" mass="32931" checksum="21B4133546FB01F6" modified="2017-01-18" version="1">MGQRDVGEPGKADLGTALRASPGYLLRRVFVLFTGEAMRDGPHSRDFVVLDVLADQDATSQQELAERLGINRTIMVRLIDRLQDAGYVTRTRNPANRRTHVLSLTEDGHGALDEMRREMSDRDARITAPLTPDERLRLNELLNELLPEPGRPPVQSTEYLVAQAHYRLRRLGDGLLADVGLRTRHFSPLAALQQLAPCPQQRLADALAITEPAAAQVVDELVQAGLVVRGRDPHDRRRYALELTDLGRQRLPVVHDAARRLRAEVVDLLGAEAEQELRALLTKLLPTEDDRPTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CW56</accession>
    <name>A0A1H6CW56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77047">
        <property type="protein sequence ID" value="SEG77047"/>
        <property type="gene ID" value="SAMN04489712_111241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG77047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="36786" checksum="1A1894C3D30D514E" modified="2017-01-18" version="1">MTGAPPDERQIEEKLLGGPLRHTRAEVEALSGIRQDYGLRIWRALGFPTPATDEVAFTDADVAALREIRELLDTDLVDEEMVLQLARGVGQTMGRLAGWLGGTWLRRLGEELPADEPVTEELVFAALAATEELRPRFERLLLHGWRRQLAAAGLRSLSTTAAATADPVGGVALMAAGFADVVSFTRLSRAMEGQELAEFVERFEATAAEVIADLGGQLVKTLGDEVFFVADDAAVAAEIGLTLAGRHETDPGFPRLRVGLAQGEVILRLGDFFGTPVNLAARLTSIAYPGAVLVDGELATALAADDDRYDISALRPRPLQGLGRVRPRLLRRRSPHPERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZY0</accession>
    <name>A0A1H6CZY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteinyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78318">
        <property type="protein sequence ID" value="SEG78318"/>
        <property type="gene ID" value="SAMN04489712_11262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="5">
        <location>
            <begin position="22"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG78318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="372" mass="39967" checksum="5A0FB231EC1AF0BF" modified="2017-01-18" version="1">MHPDSTAPSLRLGGRPLPAIGHARMYVCGITPYDTTHLGHARTFVWADVAAQVLRHAGNSVEVCRNVTDVDDVLTRAAHRAGSPYDSFAAVQQYYFEQDMASLGVHPVTHQPRAHNHVREVIALAQALLDLGHAYLREGAVYFRGADVPARAGLDRQAALDLLAEYGDDPDDPLKDDPFDIAVWRPSTSGEPAWPSPWSPGRPGWHAECAAMAMTTFGPALDLHAGGADLRFPHHAYEAALAEAMTGVRPFARSWLHVGVVRKDGVKMAKSTGNLVFVADLLRDHPASVIRLALLSRPWAQEWDYSPDDLPAAAARLDRLHTAAGRPGSAPAAEEAATAALLDDLDTGTALAIAEQEGGHTARTVLSVLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1N5</accession>
    <name>A0A1H6D1N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine protease PepD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79147">
        <property type="protein sequence ID" value="SEG79147"/>
        <property type="gene ID" value="SAMN04489712_112174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG79147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="380" mass="37519" checksum="2D2059770EDD64D8" modified="2017-01-18" version="1">MDAINPHQATGHRPPHDTHAANPHPHQPGPQDVGVGSDASQHGSQGSEAGSYTHQTRPEGFAAGPWPLQNGPQPQAGVPGQQQGQGWAGVPGFGTGPYAQQDGRQGAAWTWTARRKLMAAGAAMLIAVGAGGAGALGTMALTGNESSATGIAGTPVAAPGKSTIAQIAAAVQPSVVAVAVSTPGRSSEGSGVVLRPDGTIITNAHVVSNAARIQVKFSDGRTAPAEVLGTDTGHDIAVIKARGVSGLKAAALGDSGRLAVGDTVLAMGNPLGLDGSVTAGIVSALGRTLEEGDSPDQQGLPPGFGRQVRQESTTIRNAIQTDAAINPGNSGGALVNGSGQVVGINTAIATTGQGDGSIGVGFAIPINDAVKVVNEIISAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8T3</accession>
    <name>A0A1H6D8T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_114134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81750">
        <property type="protein sequence ID" value="SEG81750"/>
        <property type="gene ID" value="SAMN04489712_114134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="396"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="442" mass="47122" checksum="7888168800995847" modified="2017-01-18" version="1">MVTASDKTTGRRYDTSHGAVAEAERAQAMAQDATRAAERYRAEAATAGQEAERLCRSTGLSCGLYRAPNHRCTPGWAATNSRTARAWWMLSLSQITTTAGAAGNAAITCCSRARKSAALRRPSRYAHRPVVTSNAPSTVICRFLPGACDLGRSGDGARAASGSHAPGAAGAGGSRWPPTPPCQAATGAAGRRSPPPPPARAGSPRAISLGRRQMAICRRCRYTVRRLTWGRPRYRHTRGTVRGPGRCSRPAIRAGDSGPPNGGRPLRGRSARAATPRSLNRAIQRRTVPASQSSGTAICAADKPCSDSSTITARTATRHRPRRSRRNWCTWTSERLANPLDGRIPATTSPGGMDVAGNFDPPPGEAGVNALPPRRSHTRLHAEPLDTRLAETWAELRAERLRADGLERDRDQARAEATAQRERAAVAELQALRAGSPPEVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9R3</accession>
    <name>A0A1H6D9R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81425">
        <property type="protein sequence ID" value="SEG81425"/>
        <property type="gene ID" value="SAMN04489712_11453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="44926" checksum="A6098FB54FBE0EB3" modified="2017-01-18" version="1">MSTDDAVYWDPYDPRFWSDPYPTYRRLREEAPLYYNEKYDFYAVSRHADVERGLPDWQTFSSARGGILELIKSGIEIPPGTLIFEDPPLHDIHRRLLSRVFTPRRIAALEPRVRDFCTRTLDPLVGTDRFDLIEAVGAQMPMRVIGMLLGIPEADQEAIRDSADESLRTEAGGQMDFRGGAVLNNEMFGDYIDWRRDNPSNDLMTDLLNAEFEDEDGTTRTLTREEIITYVTVVAGAGNETTGRLIGWIGSLLAQHPGQRRELVADPSLIPNAIEEILRYEPPGPSIARYATKDVDFHGEIVPAGSAVLFIVAAANRDESRHPDPDRFDVHRQIGQQLTFGLGPHYCLGAALARLEGRVAMEEILKRFPRWDVDWDDAKLAQTSTVRGWETLPLIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBG4</accession>
    <name>A0A1H6DBG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82484">
        <property type="protein sequence ID" value="SEG82484"/>
        <property type="gene ID" value="SAMN04489712_11533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="35461" checksum="C613F67A37736880" modified="2017-01-18" version="1">MIKLSAGTASLAGLVLAGAGAMGGILLRPADPPPGLRAAAEVTSAPTATEQFTDERTVKVAMTVAPTPPLSVAATGRVTASYCTAGRTLKSGALAARINEKPVVALATKIPLYRDLDLGATGRDVAGLQQELRRLGHGGSTGGRYDYWTKTAVQRLMRAAGVSGPDGVLRISQVLWLPDSRVVPAKCSMVVGRQVSQGDKYATVPRRPASIRVSPMPADLAPGRRTIELMGRSGPLGKDGTVTDRDFLAALSRTREFQDLKPGDEPPAARIALAAPLRTVKVPPSAVFAVDGARGCLQSGRRVIPVRIVGSKLGTTLVLPDQAVPSTVNLGSSITARSCGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBQ6</accession>
    <name>A0A1H6DBQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ORF">SAMN04489712_11580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82761">
        <property type="protein sequence ID" value="SEG82761"/>
        <property type="gene ID" value="SAMN04489712_11580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="16"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG82761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="333" mass="36539" checksum="C7496B56247D2F06" modified="2017-01-18" version="1">MERHERQRVVFSGIKPTGRLTLGNHLGALRRFADVQYTGRCVFSVVDLHALTVDHRPARLRALTRETATLYLAAGLDPDACVLFRQSDVPLHAELSFLLECTAYVGELNRMIQYKEKGRGRPGTRVSLLTYPVLMAADILAYRASEVPVGDDQRQHLELARDLAVRFNRAYGTVFVVPEMAPAQVAARVMNLQDPRRKMSKDDPDDAPGTIRLLDPPDVVRRKVMRAVTDSGTRVRYDLEGSPGVGNLIEILGGCVGEPDLESLADRYTSYGSLKRDVADAVIALLEPLQQRYADLADDPGTVEAILRKGAERAAELAAPTITAAKQAIGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCM5</accession>
    <name>A0A1H6DCM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mannosyltransferase (PIG-V)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_115121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82999">
        <property type="protein sequence ID" value="SEG82999"/>
        <property type="gene ID" value="SAMN04489712_115121"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG82999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="43737" checksum="FC8683B02232E8F6" modified="2017-01-18" version="1">MLQDKDAETAQGRGAALLTRVRPVDRLALSLWAGAWLGVMFFVAVVPRVLPTVFDGRPYLERWAQWDAVRFVNLATYGYDGVPGQPDPGWPAFFPGYPMLLRAVGTVVPDIRIGGLLLSDYRLIGLAISLVAGAVTMVALARIGEREGPEGTGGRAVVALLAGPPAVFLFAGYSEAVFLALALPAWLLARRGRWTAAALLAVPAAGVRITGLFFALALIVEFLVGEHGRREVGWRPAAWLALPFTPLLAYSWYQWTRTGDWLAWQHAQEAGWDRHLVWPWESFKTTWQAAFQSDYEFTLAFRIEMFAALVGVLLTVYLLVKRRWPELVYVGLQLAALLLSSYYLSVGRAMLLWWPLWIAVARFGMRRPGLYAAAVAVSTPFAVLLLLTFTSGSWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCN7</accession>
    <name>A0A1H6DCN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase, sigma subunit, ECF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_115131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83050">
        <property type="protein sequence ID" value="SEG83050"/>
        <property type="gene ID" value="SAMN04489712_115131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG83050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="22738" checksum="81317F5AD23ABCD2" modified="2017-01-18" version="1">MASVSASPMDEVSDKELLSRHAQGDPHAFGELVNRHRERMWAVALRTLGDQEEAADALQDAFLSAFRAAGRFRGDAAVTTWLHRIVVNACLDRLRRKAIRPATPMGDEAKIDALAPKLPDPTDGHGTLLDVTAALRELPYEQRAALVLVDMMGYAVDDAAAFLEVPPGTVKSRCARGRARLAPRLAHLRNRQSRGNVEGTDTEGGGRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCR7</accession>
    <name>A0A1H6DCR7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ddl</name>
        <name evidence="7" type="ORF">SAMN04489712_115143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83090">
        <property type="protein sequence ID" value="SEG83090"/>
        <property type="gene ID" value="SAMN04489712_115143"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="108"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG83090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="33846" checksum="DBF3D7FD97D34B7B" modified="2017-01-18" version="1">MADLRTPELGHIVVLAGGLSYEREVSLRSGRRVADALRSLDLDVEIRDADATLLDALQAAPPDAVLPVLHGSMGEDGAIRDVLDLLDVPYVGAGPQACRIAWDKPTAKSVVRAAGLTTPPSVTLPKEVFHDLGAAALLDRVVSRLDLPLFVKPARGGSALGVSVVREAGDLPAAMVGCFAYGDAALIERYVEGTEIAVSVIERDGEPVALPAVEIVPAGELYDYTARYDAGDTEFVTPARISDEAARQAADAAVTAHRALGLRDLSRTDLIVDAVGRVNFLEVNVAPGMTETSLFPRAVTAAGLDLGRTLRDLIARRRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDA1</accession>
    <name>A0A1H6DDA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted phosphohydrolase, MPP superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82705">
        <property type="protein sequence ID" value="SEG82705"/>
        <property type="gene ID" value="SAMN04489712_11568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="48"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="33232" checksum="49B26404A99FB810" modified="2017-01-18" version="1">MRKLHAVPLGLLTAGATTFGYASVIERNWFRLRRFDVPVLPPGRSPVKVLHLSDAHLTPGRKRLIRWVRSLDELDPDLVVNTGDTISHPDAIGSFLDALGPLLERPGVFVYGSNDLYSPVLKNPLRYIWRTSQSDYKRRRRRPDLPYRELGSALSAAGWLELNNRIGRLKVGGLDVEFGGIDDSHINRDRYDQIAGPVDPRADVHLGVMHSPEPRNLDRFAADGYDLLLAGHTHGGQVCVPFYGALATNCGIDRPRVKGLHRHNGAWLHVSAGLGTSPTAPFRFCCPPEASLLTLVPRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDW7</accession>
    <name>A0A1H6DDW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC, A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SAMN04489712_11643</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83657">
        <property type="protein sequence ID" value="SEG83657"/>
        <property type="gene ID" value="SAMN04489712_11643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="472"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="506"/>
            <end position="513"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEG83657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="781" mass="85589" checksum="C559623992CE234A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFE8</accession>
    <name>A0A1H6DFE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family mycofactocin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_116110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83954">
        <property type="protein sequence ID" value="SEG83954"/>
        <property type="gene ID" value="SAMN04489712_116110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="28540" checksum="FF7D83FE8B31C52F" modified="2017-01-18" version="1">MGRLTGKVAFITGAARGQGRAEAVRLAAEGADIIAIDLVESPSRYVGYAPATQAELDETAKLVEGQGRRVLARRADVRDLQALEAVVSEGVSLLGRLDVVVANAGIVNYGRTWELTEEQWQDVIDINLTGVWKTVKATVPTLIEQGQGGSVIIISSVAGLKGLPFLAHYASSKHGVVGLAKTLANELGEHDIRVNTIHPHGVRTGMNDGGLEEFLTGSPMLGPLYMPALPYQMVEPEDIANMVAFLASDEGKYITGAQMRVDLGALNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMB7</accession>
    <name>A0A1H6DMB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, luciferase family (Includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86291">
        <property type="protein sequence ID" value="SEG86291"/>
        <property type="gene ID" value="SAMN04489712_11944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="360" mass="39778" checksum="43F59D983268DE9D" modified="2017-01-18" version="1">MKFGIMNLFPVSDGASDHQVLRDTLEEIELADHLGFDSVWLAEHHFSKYGILGSPVSFAMAIAERTKRITIGTAVLVLPLHNPLRLAEDIAALDVLSGGRVTIGVGRGYQPSEFAGFGIPLEESKVRYKETLDILRLALTQENFSYHGEVFHYDNITTYPRPFTPGGPPILQGTVSPENFRERGATGEAIITSPNFTPLGIMQKNFDLYRTAMQENGFDIASYDLPFMQQVWCGDGEEGLRAAAQAALNYYRSVGKVIPGSEQAMEKERAYYEAVAKNIELLTLEKTLTHGGNFGSAQQVIDTIELLREQLGINHYIGWLRIPSLDRRAALKSMEEFATKVIPHFRAQEPAASSAEAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRI5</accession>
    <name>A0A1H6DRI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87840">
        <property type="protein sequence ID" value="SEG87840"/>
        <property type="gene ID" value="SAMN04489712_12115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="73" mass="8116" checksum="440554420F520C91" modified="2017-01-18" version="1">MARLLAAGWWKRDAERSVELVQINGGPGLLVRVNGEIDGVVAVRVENGYITGAYHVRNPEKLSRVERETTVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRU2</accession>
    <name>A0A1H6DRU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/LC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87999">
        <property type="protein sequence ID" value="SEG87999"/>
        <property type="gene ID" value="SAMN04489712_12155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="162" mass="16895" checksum="D8FAF1FC12098396" modified="2017-01-18" version="1">MTEISSRTGGGIGRAPEDNGWMLEGLELPGVRHAVVCSRDGLPLAWSASTERWQAEHLSAACAGFAQLGDGLAAALTGASGSRAADAPAEAAGGQAVPVESVQEQFMKYPDAVLFVRGAAHNTVLAVWADKSIDPALVARQMQRQVDWIGRGMNAPARTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DS47</accession>
    <name>A0A1H6DS47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2,3-dihydroxybiphenyl 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_120155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87556">
        <property type="protein sequence ID" value="SEG87556"/>
        <property type="gene ID" value="SAMN04489712_120155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG87556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="18004" checksum="23046459BDED34B9" modified="2017-01-18" version="1" fragment="single">TGPQGMGHVVLPAPRQAETLAFYADVLGFLPRGAMKVADTPAGPVRVRFMGVNQRHHSLAVVPAPHDGDPGLVHLMVEVDTLDAVGRALDNVTRLGFSISSTLGRHTNDKMISFYVRAPGGWDIEYGTDGMLVDETYYTAEEITADSYWGHDWSGSEPLAAFVPPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT76</accession>
    <name>A0A1H6DT76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88430">
        <property type="protein sequence ID" value="SEG88430"/>
        <property type="gene ID" value="SAMN04489712_1221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="196" mass="20040" checksum="0C2177D4FFD3035F" modified="2017-01-18" version="1" fragment="single">TTTAPGQNGTWTFTGTTGQRVYFNFTGGTYGSINYATVSIKKPDGTVLIDSTRCGTSCAFNTTTLPADGTYTITLNPDAHYTGALTAQLYDVPADATAEMTINGEAQRVTTTTPGQNATLTFAGTAGQTVTINLTSNTFGSTPFAVRGPDGATLASSLGSGNVTFSNLTLPADGTYTVFVNPDRTAIGGVSGMVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUY1</accession>
    <name>A0A1H6DUY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, FadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88516">
        <property type="protein sequence ID" value="SEG88516"/>
        <property type="gene ID" value="SAMN04489712_12220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG88516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="28971" checksum="C6B4DA58054CED8F" modified="2017-01-18" version="1">MTSDLSEPSPAHQVTRKPKVSELVAAELRRQIAYGRWRAGETLPSEAVLMERFGVSRPTLREAFRILEAESLLNVRRGSNGGPQVCTPDIAVGARYVGVLLQVSGTTIADVLEARLTLEPPAAALLAARRTDQDLRDLGDCVDDFERVLEEGGDGLDAGVWVSLTQRFHDLVLERSGNQTLAVQVGVLWEVVTRHVSVAVHGFASPLRPAEIRQLAGSCRRLISLVEARDAAGAERHWREHMQTEARLLLRDDLAAVTVLEMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXL2</accession>
    <name>A0A1H6DXL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase PknG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89814">
        <property type="protein sequence ID" value="SEG89814"/>
        <property type="gene ID" value="SAMN04489712_12475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031634">
        <property type="entry name" value="PknG_rubred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031636">
        <property type="entry name" value="PknG_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16919">
        <property type="entry name" value="PknG_rubred"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16918">
        <property type="entry name" value="PknG_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="285"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="893" mass="93176" checksum="E6B53B03F6E684BF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXN4</accession>
    <name>A0A1H6DXN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90031">
        <property type="protein sequence ID" value="SEG90031"/>
        <property type="gene ID" value="SAMN04489712_12519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="13346" checksum="D51632230CE370C5" modified="2017-01-18" version="1">MSHQQAPLPAIRVTVSKQVAPEDVDRAREVIIRVLAHAPDPVLSVHLTLGVLADPAVPNPAMVSVRVDLNGRPVNAHAAGPVMPHAVALTGERLRNRLEHMSRDRRARRGHHHATAFEEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYH2</accession>
    <name>A0A1H6DYH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89806">
        <property type="protein sequence ID" value="SEG89806"/>
        <property type="gene ID" value="SAMN04489712_12472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG89806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="26894" checksum="D01E307BA1AC8C6B" modified="2017-01-18" version="1">MPTCPNGHPSAADDYCDVCGGLMTGAAPTPPPAARTTGGHPPAAGGAAGASTGAGQPPGSPDEPCPVDDTPRTGRFCETCGYDFETGNRPGGPLVTSPTLQMPVGAPAASTPSRRQPAGQPVPRPVAGPGGWSAVVAADRAYFETVLAELGPDAGSLSFPPYAPERRYMLVGPQVRIGRRSASRGFTPEIDLSAPPEDPGVSHVHAVLLARPDGTWVLVDPGSTNGTTLNGSADPIEFNVEVPVHDGDRIHVGAWTTITLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2V0</accession>
    <name>A0A1H6E2V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-monoxide dehydrogenase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91950">
        <property type="protein sequence ID" value="SEG91950"/>
        <property type="gene ID" value="SAMN04489712_13140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="782" mass="83820" checksum="AC94E04D121BED81" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3S2</accession>
    <name>A0A1H6E3S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase of IS4/5 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91981">
        <property type="protein sequence ID" value="SEG91981"/>
        <property type="gene ID" value="SAMN04489712_13155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="14892" checksum="469244F139A8602E" modified="2017-01-18" version="1">MLLELVSFGVVGSLPLVVMVERMVPDELWELFQRVVPPAPTRPQGGGRRRYGDREVLAAIIFVATSGCTWRQLPPVFGPSGPTAHRRFTEWTTTRVWPKLHRLILDELGSRGELDWSRCAIDSVNVRALKGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3U6</accession>
    <name>A0A1H6E3U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91686">
        <property type="protein sequence ID" value="SEG91686"/>
        <property type="gene ID" value="SAMN04489712_13021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="313" mass="33963" checksum="4D2106F8C0897CA7" modified="2017-01-18" version="1">MIEAITLGPPGPFRPVAADRNPRGQVRLSGGTFTMGDTFGEGYAADGEGPVHDVRLDPFLIDATTVTNAAFAAFVKDTGYVTDAERLGMSAVFHLTVQADSADVLGRATGTPWWLVVRGASWRHPHGPLSSIGALQNHPVVQVSWNDAQAYCAWAGKRLPTEAEWEYAARGGREGNRFPWGDELTPRGQWMCNIWQGTFPTHNTAEDGHVATAPVKSFRPNGFGLWNMVGNVWEWCADTFAADTYAVRAGQIPVHDPRGPLHDPSRSAPRVMRGGSFLCHDSYCYRYRVAARSSNTAESAAANIGFRCANDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3W9</accession>
    <name>A0A1H6E3W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91706">
        <property type="protein sequence ID" value="SEG91706"/>
        <property type="gene ID" value="SAMN04489712_13027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14089" checksum="FED60E1F26932582" modified="2017-01-18" version="1">MWVQTGPLIIDQVLTTAYAQVYPSGLTITIPFAGVWEVSYQARSVVNSGAANTNYWASTILYKGQSPTDGSQALAGGGPANLILQATAGQTVLAAFDANDVVSLYARGIGSQGNNASILSNTDGRITIAAHWVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4D4</accession>
    <name>A0A1H6E4D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroalkane oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92502">
        <property type="protein sequence ID" value="SEG92502"/>
        <property type="gene ID" value="SAMN04489712_13417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="9"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="34911" checksum="50626CCD773B4E38" modified="2017-01-18" version="1">MSVRDLMRHPIVQAPMAGGASGPPLAAAVSRAGGLGFLAAGYKSAAQVRAEIERVRRETDVFGVNLFVPQDAEVDAAALQAYRERLAPEAARLGTATGEPAGGNDDWDAKVADLLADPVPVVSFTFGCPSREVVEAFRERGSLVVVTVTTPEEARSVPAADALCVQGAQAGAHRGSWANADLPAYEVRDLLAAVRQITDLPLIAAGGLATGADVAQVLAAGAIAAQAGTAFLRTPESGAPAAHKAALTDPRFTATAMTRAFSGRPARGLVNRFMTEHGPYAPAAYPHVHNMTTPLRRAAAGRGEQDAMALWAGTGFRLAADRPAAEVLEALLPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E521</accession>
    <name>A0A1H6E521_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92333">
        <property type="protein sequence ID" value="SEG92333"/>
        <property type="gene ID" value="SAMN04489712_13319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="5">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="38772" checksum="BBCF2C5B63A97D15" modified="2017-01-18" version="1">MGAGHDGVAVELARRLAAAGAEARVVDVLDLLPLGLGRVLRGWYRWTVRACPWLYELIYRRFFLSARSPGAGPLAALAARRLRRAGPCTEVISTFHLAAQVTGLSRARGGLTVPSTVLITDFAVHRMWLHPGNDRYLCLDPAVTRAVSAATGRPARRYAPVVRPEFRRAAPVPARPVRGRDGTRPVLVAAGAWGVGEVEETARALAGSGRYMPIVLCGRNEALRDRLAGAGLDALGWRTDLPELMAAAYALVDNAAGLTCLEALAAGLPVVSHRPIAGHGRDGVRRMARAGLVPAARDTGELLAVLDGLADPDRRARLRARVAEVFAAPPVEDLLMPGLEPAGAPPHGEAGVPSHGEARRSSTGGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5K5</accession>
    <name>A0A1H6E5K5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_13635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92980">
        <property type="protein sequence ID" value="SEG92980"/>
        <property type="gene ID" value="SAMN04489712_13635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG92980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="301" mass="32125" checksum="0335CDC10D0301CC" modified="2017-01-18" version="1">MPDAISQILRFVDGWGRRAYPVRWSLRDTITYAIATGADARNARAFVWESAPDFGPLPTFATRFAHDALIDFAAGTQHAGLSSFARATRVRLHRPLPAECDRARAVTALSVKERSPGRLVLTLDVETCAAGETIAHSSLDVHFRVAHGRSTRPPSSGTGDTEGGGRTVEVRESVRPYQAAVFRTLLGLTADGRVQDAMHIDPVRARELGLSAPALPGEVTLGIVARLAAQNLRRLGVGGLVAAEMSYLSPVSDVDRLTIAFAPSRGGSVRTKVVNGKGRVAARGALHFRTGPTTSDRGETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8P8</accession>
    <name>A0A1H6E8P8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_13916</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93499">
        <property type="protein sequence ID" value="SEG93499"/>
        <property type="gene ID" value="SAMN04489712_13916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="627"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG93499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="856" mass="91181" checksum="3673E5F81C19D6B9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9E0</accession>
    <name>A0A1H6E9E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Branched-chain amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94312">
        <property type="protein sequence ID" value="SEG94312"/>
        <property type="gene ID" value="SAMN04489712_1466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01559">
        <property type="entry name" value="ADCL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017824">
        <property type="entry name" value="Aminodeoxychorismate_lyase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG94312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="28792" checksum="30E4EC42485749D7" modified="2017-01-18" version="1">MKIWVNGALRDPEDARVSVYDHGMLVGDGVFETVKAVRGEPFALTRHLRRLARSAAGLGLPEPDAEALRRGTLEVLATAPDWPLARIRITYTSGPGPLGSDRGAEGPTATVIVGEQRPFPPLADVCVVPWRRNEHGALAGLKTTSYADNVIALAHAKRNGGGEAIFGNLAGNLCEGTGSNVFVVRDGRLVTPPLSSGCLAGVTRDLVLEWCGGEEEDLPLAEFAGSTEAFLTSTTRDIQPIRAVDGAALPAAPGPVTAKAMEVFAARAAERVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB39</accession>
    <name>A0A1H6EB39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94481">
        <property type="protein sequence ID" value="SEG94481"/>
        <property type="gene ID" value="SAMN04489712_1483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="11394" checksum="4120B7561ADB7E90" modified="2017-01-18" version="1">MTSGALSHSFDGIADDYMVASYDPRGMSRSPLDDPQAPQQVAHHADDTFRVLELLSPDAPARVAGCSSGAIVALHLLARVQDTFRRDGLMPAVAEFAELLRKVLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5RZ71</accession>
    <name>A0A1H5RZ71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43414">
        <property type="protein sequence ID" value="SEF43414"/>
        <property type="gene ID" value="SAMN04489712_1017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF43414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="18228" checksum="01469F9898F23330" modified="2017-01-18" version="1">MLAGVTAVGLVLGLAGCEVRVPGLAASRVEPVAEPIADPRAGADGFAVRLRVIVEDGATLVLVPLRVNGRGPFEFILDTGASTSTVDRRLVGWLGLPRTGETARVTGVTGSAVVPVVKLADWTLGGRPLRGRRLTVTDIGDDRVAGLLGSDELRRFGAVTVDFRRQRLVLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S1T7</accession>
    <name>A0A1H5S1T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Voltage-gated potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43731">
        <property type="protein sequence ID" value="SEF43731"/>
        <property type="gene ID" value="SAMN04489712_10118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="132"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF43731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="363" mass="38508" checksum="71694A7328004F50" modified="2017-01-18" version="1">MFDEVSAREPRVLLPSAKVGPLRAVLHRLGIALALVLAVGTAVYLDRSGYRDIDGSMGLLDAFYYATVTMSTTGYGDIVPVSHVARLVNVVFITPARVLFLIVLIGTTLEVLAERTRTDWRLSRWRERMHDHIVVAGYGTKGRSAIRTLLGAGESPESIVVVDPDPAKIAEATGAGLAGVVGDATRSKVLLRAEADRAREIVIAAHRDDTAVLITLTARQLNPKVGIHAAVRESENAPLLLQSGADHVITSSEAAGRLLGITTTQPHVSEIMEDLLEQGTGMDLVEREVTAAETGGPIGAVAEPAIAVVRDGRMLPYSDPACARLIEGDRLVVVRAGRPRAAQGRALTGGRGRGSRPPAGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S6C5</accession>
    <name>A0A1H5S6C5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45934">
        <property type="protein sequence ID" value="SEF45934"/>
        <property type="gene ID" value="SAMN04489712_10190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF45934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="16699" checksum="465A6B7B9FA740C3" modified="2017-01-18" version="1">MDPIPLPAMSTSPSGADAFGSEAPMKVLVYSDDADTRAQVRMAIGRRPAADLPQVEYVEVATQPAVVARLDAGDIDVAVVDGEAQPAGGLGVCRQAKDEVYDCPPFVAIIARRDDGWLATWSRADAVVSQPLDPMALAQAVADLMRRRRESRLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S726</accession>
    <name>A0A1H5S726_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46389">
        <property type="protein sequence ID" value="SEF46389"/>
        <property type="gene ID" value="SAMN04489712_101102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009283708" evidence="3">
        <location>
            <begin position="40"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF46389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="240" mass="25417" checksum="1595B0D9AE9AEA2C" modified="2017-01-18" version="1">METRNSDRPLLPPWALRVMAFGALAVLVGAATPPGAAAAAEVQRFLAFYAGVFSLIAMSAAVVSGLIATERMILRIGHRVLAQAVHRASALVGFTFLVSHFLVKVLGGQAAPAQIVVPYAGPVGLGAIAFDLFLIVVITGLLRPRFASAARPWMWRMFHVTAYVAWPVAITHGLTAGRPAANWVVLSYLLCVLGVAMAAFTRLLVTVKPRSVPRGAPDTMPAATVAGQRTTSGQRQEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SA26</accession>
    <name>A0A1H5SA26_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiI</name>
        <name evidence="9" type="ORF">SAMN04489712_101126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47260">
        <property type="protein sequence ID" value="SEF47260"/>
        <property type="gene ID" value="SAMN04489712_101126"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="92"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF47260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="422" mass="46357" checksum="6E6FBFEF333E512E" modified="2017-01-18" version="1">MTVLDTTAAQPAGGPPVAGEPCVLIKLGEVVLKGRNRELFERRLQNNVRSAVRDIAPVEIWRRHGVMVVRIRPTEDTGDTERDARADVATVDALARRISDVMGIVWVHRAWRVAKDPDSVVRAALDLMAGRTGAFAVRSRRRDKRFPLTSTELDRLVGAKIVEAYQLPVRLKDPEHTLSVEVDRDEVFVFTGGLPGQGGLPVGMSGRALVLMSGGIDSPVAAYRMMRRGLRVDYLHFSGMPFTGPESIYKAYALVRELDRFQGGSRLFVVPFGKAQQQIKSSGADRLAVIAQRRLMLRTAQTLAHRLGGAALITGDSLGQVSSQTLANMTALDDAVDLPILRPLVGMDKVEIMDTARRINTLAISELPDEDCCTLLAPRRAETRAKIEDLRQIDKRLDADELAERLADSITEHRPAYGEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SG18</accession>
    <name>A0A1H5SG18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48918">
        <property type="protein sequence ID" value="SEF48918"/>
        <property type="gene ID" value="SAMN04489712_101174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF48918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="34860" checksum="7B5D193AF6DA92FE" modified="2017-01-18" version="1">MLAVSFIGSAAFYLPLLVLAFWCGNPRAAAPAGVALGLSGMLNTLLKLAFQEPRPYWTDPAVHALASESTFGMPSGHAQGSMVAWGFLAVYLTRRGWAPQLPGRLSGALRPGWVWVPTLVVIGLVGVSRVYLGVHSPGQVAAGWAIGGALLFVVVRFGPVVAGRWRDLRLVWQFVLSAVVSLGLLACAVAAVAPLRNWRMPPVWQEAIIRAGGHVDVHPDRLGMERAALAAGLLCGLLVGLSWLAHRGWFAAGGPPLARVSRVLVGVAGLAVINTVLLLPAPHVAVLFLAQALTGLWITVGAPEAFVRLGLARRPTPGLTRPGEPALTRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SH09</accession>
    <name>A0A1H5SH09_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">SAMN04489712_101185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49228">
        <property type="protein sequence ID" value="SEF49228"/>
        <property type="gene ID" value="SAMN04489712_101185"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF49228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="170" mass="17739" checksum="206B310DF66E93B7" modified="2017-01-18" version="1">MSGAGRPEQTTVNAAELTLGIACTRWHGQITDRLLERAVLAAKECGVGDPVVVRVAGALELPVVAQQLARDLDAVVCLGAVIRGETAHFDYVCDSVTAGLTRVALDEATPVGNGVLTCDTIEQALDRSGLPGSREDKGWEATVAALDTALTLRGLRHHGPAGHLSEHLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SK14</accession>
    <name>A0A1H5SK14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ORF">SAMN04489712_101247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50963">
        <property type="protein sequence ID" value="SEF50963"/>
        <property type="gene ID" value="SAMN04489712_101247"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF50963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="20163" checksum="3CE25BA6959316AB" modified="2017-01-18" version="1">MATTNDLKNGMTLNLDGQLWTVLEFQHVKPGKGGAFVRTKLKNVLSGKVVDKTFNAGTKVDVASVDKREMQYLYREGEDFVFMDTETYDQPHIPGTVVGDAADYLLPEQNAVIAFNNDNPLYVELPAAVVLEVTHTEPGLQGDRSTGGSKPATLETGAEIQVPLFITTGEKVKVDTRSGEYLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SN20</accession>
    <name>A0A1H5SN20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51840">
        <property type="protein sequence ID" value="SEF51840"/>
        <property type="gene ID" value="SAMN04489712_101281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF51840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="112" mass="12120" checksum="056C033BF6223DE5" modified="2017-01-18" version="1">MRTVESATDAADPMVRLPLTREVRSLQEARAAIDEVDAALALLLARRAELAGAVQRLKPVGGFAGRDPHRERQIVEAMARRAPALGVDRLARIMNAVIEAGLEAAEDAREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SPZ1</accession>
    <name>A0A1H5SPZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisA</name>
        <name evidence="10" type="ORF">SAMN04489712_101312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52595">
        <property type="protein sequence ID" value="SEF52595"/>
        <property type="gene ID" value="SAMN04489712_101312"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010188">
        <property type="entry name" value="HisA/PriA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01919">
        <property type="entry name" value="hisA-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF52595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="240" mass="25187" checksum="DE4CB11AAFC49866" modified="2017-01-18" version="1">MTLTLLPAVDVADGQAVRLVQGEAGTETSYGSPLEAALAWQGAGAEWIHLVDLDAAFGRGSNRELLAEVTGRLDVRVELSGGIRDDASLEAALATGCARVNIGTAALENPEWCRKIIAEYGERIAVGLDVRGTTLAARGWTREGGDLWEVLARLEEDGCPRYVVTDVTKDGTLRGPNTDLLREVCSRTDKPVIASGGVSSLDDLRALAGLVGDGVEGAIVGKALYAQAFTLQEALAAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SUT2</accession>
    <name>A0A1H5SUT2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="20" type="ORF">SAMN04489712_101370</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54214">
        <property type="protein sequence ID" value="SEF54214"/>
        <property type="gene ID" value="SAMN04489712_101370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="43"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="447"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="17">
        <location>
            <begin position="668"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="627"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="664"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SEF54214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="713" mass="80776" checksum="7ACD7349763EFA9B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SYT1</accession>
    <name>A0A1H5SYT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55710">
        <property type="protein sequence ID" value="SEF55710"/>
        <property type="gene ID" value="SAMN04489712_101416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF55710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="257" mass="26925" checksum="5F66FE5E015B4DBE" modified="2017-01-18" version="1">MFNRNMADTERLRRITEAVREAGRVSVAELAGLTGASEMTIRRDLEVLAAQGVVERYRGGARSLLLRGEEPPFVLRAQEGLEVKRRIAAEVAELITDGEAVVLDGGTTCLEVALALEHRRLTVMPLSLHVVNALTGAPQMTLLVPGGRPRPGELALTGPLTEASLAALRFDTAIIGCCGLTATGGLTAHDLGEAAVKRAAIASSRRVIAVAEAAKLSRTALAFVAPASALHAVVTDDTADDDETDPLVAAGVVVRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TK15</accession>
    <name>A0A1H5TK15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-binding zinc finger CDGSH type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62347">
        <property type="protein sequence ID" value="SEF62347"/>
        <property type="gene ID" value="SAMN04489712_101625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="4">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF62347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="77" mass="8771" checksum="6968779150143089" modified="2017-01-18" version="1">MQTESRSEPRSEPRRPDRRRVIVEAGGPVLVEGPVEVVMADGTTVTCDRFMVALCACRRSRRLPFCDTSHRRKQRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TR17</accession>
    <name>A0A1H5TR17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65235">
        <property type="protein sequence ID" value="SEF65235"/>
        <property type="gene ID" value="SAMN04489712_101715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF65235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="27403" checksum="6D836A7A04A7F3CF" modified="2017-01-18" version="1">MTSGETRVAVVTGGTSGIGLAVARLLGRSGLRVFLCARSADDVAHVVKELRDEGVEADGQACDVRSTEQVEAFVRAAVDRYGRVDVLVNNAGRSGGGPTAQLTDELWLDVIDTNLTSVLRVTRAVLTRGGMLERGRGRVINIASTGGKQGVVLGAPYSASKHGVVGFTKALGLELAKTGITVNAVCPGYVETPMAQRVRQGYAQVWETTEDEVLERFQAKIPIGRYGTPEEVAGMVGYLVSEPAAPITAQAINVCGGLGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V4N5</accession>
    <name>A0A1H5V4N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82372">
        <property type="protein sequence ID" value="SEF82372"/>
        <property type="gene ID" value="SAMN04489712_102167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF82372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="48" mass="5045" checksum="EF36E2FF81C0E66D" modified="2017-01-18" version="1">MSPPGPSPPPMRGIAKRLPGVRALTHDARAIVMGEPGMIKPIMEGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V5U0</accession>
    <name>A0A1H5V5U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82118">
        <property type="protein sequence ID" value="SEF82118"/>
        <property type="gene ID" value="SAMN04489712_102158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="97"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF82118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="233" mass="25323" checksum="60D737B0A1779B00" modified="2017-01-18" version="1">MILLTTLHAWTSRTADRLDLSDGRMAWVPGGDLGDALAVLDGAPDVFGDAQVVALTLDPEPSDVRLLRAADPSHVAEIRYARRGPDGRYTGLLSRPEIAEELDLLPHPEGGWFRETWRTPVAFQPPGYPGERASATGIYFFLPPGEESMWHQVRSDELWAYHLGDPLVLELGGTGERPGRPEPVVLGPQVARGQRPQVLVPAATWQAARPDGAEGTLVSCVVSPGFDFADFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VEV7</accession>
    <name>A0A1H5VEV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85859">
        <property type="protein sequence ID" value="SEF85859"/>
        <property type="gene ID" value="SAMN04489712_102296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF85859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="32975" checksum="F6542C7BAC910AA3" modified="2017-01-18" version="1">MFPGQGSHRPGMGRPWAGRPGWDLVGRAAEITGRDVAALLLDADEPTLRRTENTQLATFVLELVILAELTGLGTDTGTGPVTPVACAGHSLGEFTALVAAGVLSIDDGIRLVHARGTAMREAAAAEPGAMSAVLGLDQDEVEDVAAGLRADGARVWAANLNAPGNVVVSGTPDGVARCGEEAVRRGALRVVGLPVGGAFHTPLMAPALGPLEAVLETAVFADGHAPVVANVDAEPHGGGPDWRGRLLRQLTGPVQWSRTVPVLTERLGCDLLLEVGPGRTLTGLAKRLAPRAVRADIGEPDRIADVVLRADLVAGRAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VFC9</accession>
    <name>A0A1H5VFC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Act minimal PKS ketosynthase (KS/KS alpha)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85491">
        <property type="protein sequence ID" value="SEF85491"/>
        <property type="gene ID" value="SAMN04489712_102282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF85491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="424" mass="44798" checksum="DC1F587AD6694DDA" modified="2017-01-18" version="1">MIGRRVVITGIGVQAPGGDGVKEFWSLLSEGRTATRPISLFDASPFRSRVAAEVDFDAEAHGLTPREIRRMDRATRLAVVAAREAVADSGLDFAGLDPARTGVAVGSAVGCTMGLEEEYRVVSDDGRDWLVDHSYAVPHLYRHFVPSSMAAEVAWQVGAEGPVSVISTGCTSGLDSVGYARELIAEGSADVLVAGATDAPISPITVACFDAIKATTPRNDDAAHASRPFDNTRNGFVLGEGSAMFVLEELESARRRGATVYAELAGFASRCNAFHMTGLRPDGREMAEAIGAALAEARVDPGDLDYVNAHGSGTRQNDRHETAAFKRSLGEHARRVPVSSIKSMIGHSLGAIGSLEIAACALAMRHDVIPPTANLHEPDPECDLDYVPLTARERRTDTVLTVGSGFGGFQSAMVLTRPGARAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VJ22</accession>
    <name>A0A1H5VJ22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86547">
        <property type="protein sequence ID" value="SEF86547"/>
        <property type="gene ID" value="SAMN04489712_102320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF86547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="12423" checksum="92B5193351C5ED33" modified="2017-01-18" version="1">MNNAPTLRWRKSSHSGGDHGNCVELAALPGAAAAAWRKSSHSGGEHGSCVELAVLPNVAAAAWRKSAHSGGEHGGCVELAAVRDVLAIRDSKHPAGPVLLLSRHELSALLTSVRSGEHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VUE1</accession>
    <name>A0A1H5VUE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Superfamily II DNA or RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90471">
        <property type="protein sequence ID" value="SEF90471"/>
        <property type="gene ID" value="SAMN04489712_102450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF90471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="583" mass="64194" checksum="073985BB65833007" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W289</accession>
    <name>A0A1H5W289_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_102556</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93356">
        <property type="protein sequence ID" value="SEF93356"/>
        <property type="gene ID" value="SAMN04489712_102556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF93356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="624" mass="66048" checksum="3A9A875F24CA8A3F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XB92</accession>
    <name>A0A1H5XB92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08710">
        <property type="protein sequence ID" value="SEG08710"/>
        <property type="gene ID" value="SAMN04489712_103165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG08710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="33" mass="3408" checksum="E13B7161337D8D39" modified="2017-01-18" version="1">MPAAAVPTVVPTALVLAVVALWFSLHLAEHVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XBW2</accession>
    <name>A0A1H5XBW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein N-acetyltransferase, RimJ/RimL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09238">
        <property type="protein sequence ID" value="SEG09238"/>
        <property type="gene ID" value="SAMN04489712_103185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG09238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="169" mass="18467" checksum="B13F81C33F47B2AB" modified="2017-01-18" version="1">MLGPAIDTITTQRLLLEPLRVEHAEEMVSVLDDPRLHTHIGGAPLPLPELRARYRHLVTGPAPYHQQAWLNWIVRRRRDGRPVGTVQATVTPGPEAAVAWVIGMPYQGFGFATEAARALIGWLHAQGITVIRANIHPDNAASVAVARKLGLRPTADHAGDEVVWRLTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XWF9</accession>
    <name>A0A1H5XWF9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103438</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15983">
        <property type="protein sequence ID" value="SEG15983"/>
        <property type="gene ID" value="SAMN04489712_103438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="5">
        <location>
            <begin position="472"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG15983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="699" mass="77226" checksum="A7AFDF9589598CC5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XXM2</accession>
    <name>A0A1H5XXM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">SAMN04489712_103463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16559">
        <property type="protein sequence ID" value="SEG16559"/>
        <property type="gene ID" value="SAMN04489712_103463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG16559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="26571" checksum="33C99EC43BF980B5" modified="2017-01-18" version="1">MAVMDINADLGEGFGVWTLGDDLALLEIVTSANVACGFHAGDPLVMRRVCRAAVTRGVAIGAQVSYRDLAGFGRREIEMAPDELTAEVLYQLAALDGIARAAGGRVSYVKPHGALYNRIARDREQAGAVVEAIRDYDPSLPILTLPGSAVHEVAGPLTVIAECYADRAYTPEGTLVPRRRPGAVVHDADTVIERAVRMAVEGVVIAVDGTKVPVDARSICVHGDTPGAVELARAVRGALAAAEVDVRPFALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YH88</accession>
    <name>A0A1H5YH88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23344">
        <property type="protein sequence ID" value="SEG23344"/>
        <property type="gene ID" value="SAMN04489712_1049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG23344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="383" mass="41799" checksum="FEC060A371D0648B" modified="2017-01-18" version="1">MPAASGHLRHRGVWKHETVPNDAVHGGSARFAARLVGTVAAPLDPAAADAPQVLSWPGRRLLVQRGDTELAVRDLDGDGTQVRFPAPWPRRYGSVAVSPAGDVAVFAGVHALRAVDATGAVRWEIRHGCWSAAVCTKAHVSFREYADDHHHGHADSGSAAFSSDGKLLWAHIRTYSGQDSEEEWLILDPADGTVLTRAATMTVGSGSFHFPHPDPAYMGLTVAEGEEDSPVLWGHWDGAKLTVQRFVEEVLLAVSPSGEHFLTTDTGQWDLYLHRAEDGMELRRLDAEGAVPPLSSEDDDRVRWDFEAAFPYDDTAVVGTEYYAQAPRHWLVDPRTMALRGRIAYPFPVSGSPRSAGQGAWYTVSRDQTALHLWHLPDGEQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YIN1</accession>
    <name>A0A1H5YIN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23562">
        <property type="protein sequence ID" value="SEG23562"/>
        <property type="gene ID" value="SAMN04489712_10418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="113" mass="12440" checksum="BB6972C0B9FFB272" modified="2017-01-18" version="1">MRADAVRGHLDGLLLSVLESGPLHGYAIITAVQERSGGALELRKGTIYPALNRLERLGLLRSTWESAGERRRRRYELTDAGRRSLAAERTAWREFTTVIGAVLNPAPISGQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YSF4</accession>
    <name>A0A1H5YSF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26592">
        <property type="protein sequence ID" value="SEG26592"/>
        <property type="gene ID" value="SAMN04489712_104141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG26592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="154" mass="17965" checksum="3A4E78348C11A555" modified="2017-01-18" version="1">MRFHSLPESKRYAEDEAEYAVVLERYNSVLDELFAGTDVYVITAVWTTEPDVPAGRLSTGYWRSLLVADDPDPEFRTYYHLFVTRLPWRRGCIDDLLRDVADERVADVLITDTRMQRIHHPYDGGADVFLPTSEERDRLRDRYADWLSNHPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZ92</accession>
    <name>A0A1H5YZ92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiol-disulfide isomerase or thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29563">
        <property type="protein sequence ID" value="SEG29563"/>
        <property type="gene ID" value="SAMN04489712_104273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291068" evidence="3">
        <location>
            <begin position="28"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="45"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG29563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="20695" checksum="6898398262DD7249" modified="2017-01-18" version="1">MARVRVVAAGAVAACALLAGCAGTQGAQTGPGSGDNRFIAGDGTAQVIKATDRRAAPRVEGTTLEDKPLRLADLGGKVVVLNFWASWCGPCRGEAPTLQKLSTEHKPKGVEFVGVNFKDFKEPARAMERTFQVTYPSLYDHDGRLMLEFRDVPPSAVPSTLIFDRQGRIAARIIGPTTYSQLNPLITQIAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z3M8</accession>
    <name>A0A1H5Z3M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heptaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30257">
        <property type="protein sequence ID" value="SEG30257"/>
        <property type="gene ID" value="SAMN04489712_104301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG30257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="35197" checksum="E0180F6041BC3E07" modified="2017-01-18" version="1">MNSGVPFGLPVDDALAADMRERLTAVEGLLAESIVCDDPLLTEASRHLVEAGGKRFRPALVLLASHFGDPAAAGVVPAAVVVELTHLATLYHDDVMDEATMRRGEVSANTRWTNTVAILTGDYLFARASDLLADLGPQAVRIQARAFARLVRGQIAETSGPGPDADPLKHYLQVVADKTASLIAVSGQLGALLAGARPHEVDTITSACEKIGVAFQLSDDILDVASESEQSGKTPGTDLREGIRTLPVLHVLSSTDPADARLRDLLGRDLTDDALHAEALALLRAHPAMERARADLRRWADDARAELLTLPAIPARDAFTGLCDYVVSRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z9V8</accession>
    <name>A0A1H5Z9V8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">SAMN04489712_104439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33082">
        <property type="protein sequence ID" value="SEG33082"/>
        <property type="gene ID" value="SAMN04489712_104439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="152"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG33082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="31141" checksum="E157D9570D952ED3" modified="2017-01-18" version="1">MTALVRLRLDIGYDGSEFAGWARQPAQRTVQGVIEEALGRVLRLDPPPALTVAGRTDAGVHARGQVAHVEVPADAYEAAGGRLLRRLAGVLPPDVRVWRVAPAPDGFDARFSALSRRYVYRVCDDPVGVDPLRRRDVLWHPWPLDLDRMNEAAALLTGEHDFAAFCRRREGATTIRRLLRYEWAREEPRLAAAAVEADAFCHSMVRALVGALLVVGDGRRDVGWPAEVLGARVRDSAVNVAPAHGLSLEEIRYPDDADLARRAQETRRVRTLSVTGGGAADGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZCE2</accession>
    <name>A0A1H5ZCE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33307">
        <property type="protein sequence ID" value="SEG33307"/>
        <property type="gene ID" value="SAMN04489712_104449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG33307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="339" mass="36014" checksum="D2AE9E85A4465074" modified="2017-01-18" version="1">MPIIATQGLTMRFPGVTALHDLTVAVEPGVVGLVGANGAGKSTLIKILLGLLPATAGQASVLDLDVARQGPLIRERVGYMPEYDCLPPDVSATEFVVHMARMSGLPPTSARERAADTLRHVGLYEERYRPIGGYSTGMRQRVKLAQALVHDPRLVFLDEPTNGLDPAGRDEMLDLIRRIGTEFGISVLVTSHLLGELERTCDHVVIIDGGRLLRSQAVEAFTTDSGTLTVEVEEGRDALGHRLAAAGLAVRPDGRLLLVDVAGEHTYDLIRDAVVELDLSLIRMERRRHHIEEVFATPPPGPGTATVPPHAAVPPGPVPPGVVGPGVVGPGGIERGHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A721</accession>
    <name>A0A1H6A721_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43837">
        <property type="protein sequence ID" value="SEG43837"/>
        <property type="gene ID" value="SAMN04489712_105219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025557">
        <property type="entry name" value="DUF4282"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14110">
        <property type="entry name" value="DUF4282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG43837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="15711" checksum="EA0E65C2D798D813" modified="2017-01-18" version="1">MGTPYGPGQPPGWQQPGQPYPPQPAAYQQPAGPRYDNDKGFFGSLFDFSFDNFIAPKLVKFLYVVSLILLTLFAIGYIIFGFAAMASGDDSGAVVGLLIIIAAPIIWFLYVMVTRVWLELLIVMFKISEDIKDIRDSRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AEH3</accession>
    <name>A0A1H6AEH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParB-like nuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46891">
        <property type="protein sequence ID" value="SEG46891"/>
        <property type="gene ID" value="SAMN04489712_105389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="439" mass="48289" checksum="187FDFC62CE9D42E" modified="2017-01-18" version="1">MSPMLDQVRRRSRTVLRKAGVAPNGPVYGRLVDAGRSVPIPPRARVALSTAVLRRPWPITVPLDRLLLGAQGGWTAREFAERTGDLLWPSTPLLEGPHVALLRLADERGEPSDDELSDTAYCRLGMRCVAAGGNYFGATDEEGVIRAARAFIARYRGKTPASDALRPAQSGPRDPVLVAPVRGSGYYQVLDGHHRLAVAAVRGRTTVPVVAKWMPVTTPLQDHLLRMSWLDGTKQLYQPIDSPELRSGWVTVRRCTDRLDKMTDFLAERGIAAPASYLDVASCYGWFVAEMGRRGFDATGMERDPLAVPLGQAVYGLTDGAVTTGDAVELLRGADRSWDVVSCFSLLHHFVLGRGSVGPEELIRLLDGVTGRVLFFETGQGHETWFRDSLRGWDTARVEAFLRAHTTFDEIVDLGPDDDARPPFADNYGRTLFACVRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AGD2</accession>
    <name>A0A1H6AGD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multicopper oxidase with three cupredoxin domains (Includes cell division protein FtsP and spore coat protein CotA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_105443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47829">
        <property type="protein sequence ID" value="SEG47829"/>
        <property type="gene ID" value="SAMN04489712_105443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="266"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="566"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG47829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="684" mass="71456" checksum="DA732AD289B6D3C9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AL72</accession>
    <name>A0A1H6AL72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_105534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49479">
        <property type="protein sequence ID" value="SEG49479"/>
        <property type="gene ID" value="SAMN04489712_105534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG49479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="26163" checksum="D06E1B3CDC2CE0B4" modified="2017-01-18" version="1">MNEPLLQVRGLTVSYGGGSVAVDQVDLDVHDGEVCLVLGANGAGKTSLLRGIGGFAASERGRVRSGKVLIGGADVTGRPPRTMVGHGVVLVPEENKVFRTLTVGENLRAAPMTGDRGSRRELLDEVVSLFPFIRERMDLPAGQLSGGERQLLGIARALLLKPRLLMVDEASLGLSPIAVRKVFDSLHSLVAAKGMTLLIVEQNVRAARAIADRAHVMVSGTFALSGPAREVLESEQVRRTYLGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AMU5</accession>
    <name>A0A1H6AMU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49096">
        <property type="protein sequence ID" value="SEG49096"/>
        <property type="gene ID" value="SAMN04489712_105514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG49096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="51" mass="5112" checksum="EC75F6D8088DEF86" modified="2017-01-18" version="1">MVSGGLLAVGTLTNRPDSADKGKRALIWSLAGVVVTAIAIPMVNTVFSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AX31</accession>
    <name>A0A1H6AX31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR02680 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52904">
        <property type="protein sequence ID" value="SEG52904"/>
        <property type="gene ID" value="SAMN04489712_10661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013496">
        <property type="entry name" value="CHP02680"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02680">
        <property type="entry name" value="TIGR02680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="744"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="928"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG52904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1379" mass="153179" checksum="7FE8C842E648A380" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B1X6</accession>
    <name>A0A1H6B1X6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Poly(ethylene terephthalate) hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.101</ecNumber>
            <ecNumber evidence="4">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_106167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12420"/>
            <dbReference type="Rhea" id="RHEA-COMP:12421"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:131701"/>
            <dbReference type="ChEBI" id="CHEBI:131704"/>
            <dbReference type="EC" id="3.1.1.101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:49529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47348"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:50477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:47349"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.101" evidence="8"/>
    <dbReference type="EC" id="3.1.1.74" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="9actn-a0a1h6b1x6">
        <property type="family name" value="Chlorophyllase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54604">
        <property type="protein sequence ID" value="SEG54604"/>
        <property type="gene ID" value="SAMN04489712_106167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="Chlorophyllase2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="Chlorophyllase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293239" description="Poly(ethylene terephthalate) hydrolase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG54604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="30987" checksum="F6642405EE94FD89" modified="2017-01-18" version="1">MRTRKAGTALAAAVALAAVALPAAPAAADAPIEFATTVNGDAADVYAPAPGDIKADLPVALLLQGANVDKSNYAAYARAVAGYGFVVVVPNHQRVIFGQPGLYAEEAQAAWTVTWMKQEDARTGSPLKGKIDTGSLVLLGHSFGGAAGLTLTTGACVAPFCDTPTTKPAELKGGAFYGTNNLPPGGSVNPPVANTVPVALIQGTADGRATPAAAEGTYNAIQTPPKMLVSVTGANHYGITDTQAPAGALPDPSPQTVTQETSIKASARWSAMYLRTILGDVWSGVWLWGVGDAVDSSVTVQYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B7B1</accession>
    <name>A0A1H6B7B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56107">
        <property type="protein sequence ID" value="SEG56107"/>
        <property type="gene ID" value="SAMN04489712_106285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG56107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="189" mass="21580" checksum="B07642F83B0E748E" modified="2017-01-18" version="1">MGEHVAFWVDHDYDRERAVTGLSRYGEHVRRNVADFAESWGDIAPVTFACTAWRLATVPSLTPGYVRWHRRVWKATCTRNAWDGSLTAHIKLVSPPPAELTASREWWRDRGWRGWPQVFGQFLKPSDEELSKSPHLRTTLLVDAPVPLDHLPAAPEGPDADFEETARHAVAVMVKELNELINPIIRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B842</accession>
    <name>A0A1H6B842_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56575">
        <property type="protein sequence ID" value="SEG56575"/>
        <property type="gene ID" value="SAMN04489712_106322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040664">
        <property type="entry name" value="AFL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18067">
        <property type="entry name" value="Lipase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293439" evidence="1">
        <location>
            <begin position="39"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase_C" evidence="2">
        <location>
            <begin position="219"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG56575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="451" mass="48603" checksum="B158EB396B79E2D3" modified="2017-01-18" version="1">MRCTPGIPPVGASRLRRAFGLLAAVLLLTALVPATAGAAARAALRPIVFVHGFFGSGSQFATQAKRFASNGYPASHIQYEEYDSLFVSNTREEVLASLDRRIAQLKAATGADKVELVGHSLGTSISQEYLNSSPQRAADVAHYVNIDGTTATSLPGGVPTLALWAEGREDSTITGATNVHLPNESHVENASSPASFAAMYEFFTGRKPQTTQVVAEQGEIQLAGRAVRFPSNTSPGDAVVDVFEVDPATGRRTTQQPIQSMRVSADGSFGPFRASGSAYYEFRLTRSDTDQQHHLYFEPFRRTDLGVRLLSSDPGRGVDRLIQRGPGHVALLAYRNKEWWGDQGAGGDTLTINGVPVVNEGTAPRDKRAIGLFAFDRFSDRRSHPDRSFGLFPALPFMTAVDLFMASAEPATGTVTLATTQRGGGRPTRITIPNWPSQTHTVTVNFNDHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B904</accession>
    <name>A0A1H6B904_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein Hsp15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56875">
        <property type="protein sequence ID" value="SEG56875"/>
        <property type="gene ID" value="SAMN04489712_106344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025708">
        <property type="entry name" value="HSP15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016821">
        <property type="entry name" value="HSP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG56875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="131" mass="14731" checksum="34022046F1A6AF73" modified="2017-01-18" version="1">MAAEEGSVRVDVWIWSVRLVKTRSQATNACRAGHVRVNDVRVKPASVVRPGDEVRVRLDGRERIVVVQRIVRKRVGPPVARECLIDKSPPPPPREALIPIGLRERGAGRPTKRDRRELERLRRQSAAPDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BD55</accession>
    <name>A0A1H6BD55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58590">
        <property type="protein sequence ID" value="SEG58590"/>
        <property type="gene ID" value="SAMN04489712_1073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017595">
        <property type="entry name" value="OHCU_decarboxylase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03180">
        <property type="entry name" value="UraD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="3">
        <location>
            <begin position="49"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG58590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="22877" checksum="284C558D39A99C06" modified="2017-01-18" version="1">MSEPEARGADLAEERADRGTREYATRERHASRPGTGVQAGTREPLEWLNALPAGDAERELLACCGSQAWAGSVAAGRPYRDAAALKNACDRAFNALTWADVEEALARHPRIGDRPRGVDRASGWSRGEQAGVQGADRQVMRALHDGNLAYEERFGHVFLVCATGLTARRMLAALRERLGNDEAAERRTVRGELLKITHLRLDKLLERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BHX5</accession>
    <name>A0A1H6BHX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60348">
        <property type="protein sequence ID" value="SEG60348"/>
        <property type="gene ID" value="SAMN04489712_107125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG60348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="31422" checksum="1782913B20C9DA80" modified="2017-01-18" version="1">MNRAVQPPYPHASGVRPPAIPKQFVPRHVAIVMDGNGRWAKERGLPRTEGHKMGEHSLFDVIMGAIELGIPYLSAYAFSTENWKRSPEEVRFLMGFNRDVIRRRRDQLHSMGVRVRWAGRRPRLWRSVISELEDAERMTRDNDVLTLQFCVNYGGRAEIADAAAALARDVAAGRLDPDKVNEKVFARYLYRPEVPDVDLFLRPSGEQRSSNFLIWQSAYAEYVFQDVLWPDFDRRHLWHACEVYATRDRRYGGAEPNPVPAAVHDVTGHAVNGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BVI2</accession>
    <name>A0A1H6BVI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tat (Twin-arginine translocation) pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64226">
        <property type="protein sequence ID" value="SEG64226"/>
        <property type="gene ID" value="SAMN04489712_1084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG64226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="389" mass="41170" checksum="33D93F23984AC6C4" modified="2017-01-18" version="1">MPTGLNRRTFLRTTTVAGGTAAFSGALWQRAFAGPAQPGAGPYGPLQAADANGIRLPSGFTSRVIARSMQRVPGTRYTWHPAPDGGACFPAGDGWIYVSNSEVPLVGGASAVRFGPSGEIADAYRILTMTTLNCAGGATPWGTWLSCEEYALGIVYETYPQGGRSAVQRPAMGRFKHEAAACDPERKVVYLTEDEGNGCFYRFRPAAWGDLSRGTLEVLVGSGVGAVTWRPVPAPELWTTPTRDQVQGAMRFTGGEGCYYAGGVCYFTTKGDGRVWAYDAANSTLDLAYDDDLVTGGEAPLTGVDNITGTVSGDLYVAEDGGNMEINMITPEGVVTPFLQVLGHDESEITGPAFSPDGSRLYFSSQRGRSGFIGGTDGHTYEITGPFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C073</accession>
    <name>A0A1H6C073_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exodeoxyribonuclease V alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66340">
        <property type="protein sequence ID" value="SEG66340"/>
        <property type="gene ID" value="SAMN04489712_108184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029493">
        <property type="entry name" value="RecD-like_HHH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14490">
        <property type="entry name" value="HHH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HHH_4" evidence="1">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="583" mass="59461" checksum="81ADFFA82372235A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C170</accession>
    <name>A0A1H6C170_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66613">
        <property type="protein sequence ID" value="SEG66613"/>
        <property type="gene ID" value="SAMN04489712_108208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="309"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG66613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="44002" checksum="A731AA1D8247818B" modified="2017-01-18" version="1">MSPRIRNLVEGRAWLRRHPQVADLIVAVLLLAAGVPQLLLTELPVDAAVHFRSPDAVNALLVAAVTLPLALRRTLPMTVLMFITAGQLLLAGLNYPSSPADVAAFLIAIYSAAAHRALAHSALGGLIAFAAFNVMLVLYDLHTSFLDYVTNCALLVGVWLLGRNLRLRRAYLAELEDRAARLERARGTDARAARVEERSRIARELHDVVAHHVSVMTVQAGAARRILDRSPDSAREAMGTIEEVGRTALSEMRRIVGVLRTERDTAPAGQELSPQPGIADLGELIDHVRETGLSVNLWIEGEARTLSPGVDLAAFRLIQEALTNTLKHAGPQARAWVRLRYTDADLTVEIEDNGRGAETLLSGNGDRPGHGLVGMYERVALYGGELRIGPRVGGGFGVRARFPLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2J6</accession>
    <name>A0A1H6C2J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein YecE, DUF72 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66917">
        <property type="protein sequence ID" value="SEG66917"/>
        <property type="gene ID" value="SAMN04489712_108237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="32126" checksum="1B4C1984AC2E0609" modified="2017-01-18" version="1">MWTHAPWQGRFLPHPLPPKERLRSYATWCNAVEGNTTFYATPARSTVESWARQTSPDFRFVVKLPRSITHERRLTGAEEELRSFLTAIEPLGPRAHALWVQLPGSFTPADLGALAGFLRRLPRSHRYAVEIRHRAFFEDPRSARLLEQVLTGVGAEWVPFDTTVLFQSPPTSDSERDAWTKKPRLPRRAPALTDRPIVRYLGRDDTERTVEGWRPWADTFARWLREGRSPTMFVHTPDNADALMLARRFHEDVRARLPEVEPLPEPAPATPSPAEQPTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C332</accession>
    <name>A0A1H6C332_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dolichyl-phosphate-mannose-protein mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_108249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67055">
        <property type="protein sequence ID" value="SEG67055"/>
        <property type="gene ID" value="SAMN04489712_108249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="8">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG67055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="522" mass="55713" checksum="591E6D598574742E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C3J6</accession>
    <name>A0A1H6C3J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycofactocin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67215">
        <property type="protein sequence ID" value="SEG67215"/>
        <property type="gene ID" value="SAMN04489712_108264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023988">
        <property type="entry name" value="MftA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03969">
        <property type="entry name" value="mycofactocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG67215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="48" mass="5007" checksum="4CFEF17F16DC19F7" modified="2017-01-18" version="1">MSGLSQVPASVSPSPAQDERATAPDGQDLLEQDLLVEEVSIDGMCGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C738</accession>
    <name>A0A1H6C738_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68820">
        <property type="protein sequence ID" value="SEG68820"/>
        <property type="gene ID" value="SAMN04489712_10922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="69" mass="7521" checksum="DC0D42D2D200F50D" modified="2017-01-18" version="1">MAEIRVGEPDVSPDAPAHTRGVREGNTRGAYRHEVGHHMDDTVDARKSTGVRPQDRDPILPSMPNLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7L2</accession>
    <name>A0A1H6C7L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68912">
        <property type="protein sequence ID" value="SEG68912"/>
        <property type="gene ID" value="SAMN04489712_10931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017101">
        <property type="entry name" value="P-loop_ATP/GTP-bd_All4644_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037081">
        <property type="entry name" value="P-loop_All4644_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG68912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="16522" checksum="859857C33C53C162" modified="2017-01-18" version="1">MVGSVPNPPARPPEVVVMVGLQGSGKSTWVARHLAATHEIVSKDHWPNARHRERRQRRVLNELLAAGRDVVVDNTNPAPADRAPIIEIARAHGATVRAVYLDVPLHICLARNENRQGRARVPLVGVLAALKRLVPPSADEGFDRVDTVTTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9X4</accession>
    <name>A0A1H6C9X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69425">
        <property type="protein sequence ID" value="SEG69425"/>
        <property type="gene ID" value="SAMN04489712_10982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG69425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="25944" checksum="B6A34FAC137F1DC2" modified="2017-01-18" version="1">MSAADVPVLDVRDITKVYGEGETAVHALRGVSLQVRRGDYVAIMGTSGSGKSTLMNILGCLDVPTSGRYLLDGTDVGALSEARLSVLRNRRLGFVFQSFNLIPRMSALANVELPMAYGGVPAGERRRRALAALELVGLGDRVRHEPNELSGGQQQRVAVARALVTAPALLLADEPTGNLDTRSTRDVLDILGRLNARGRTIVLITHEDEVAAHARRVVRLVDGRIVEDRRNAPAPALREAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CA51</accession>
    <name>A0A1H6CA51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hemolysin, contains CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_10990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69505">
        <property type="protein sequence ID" value="SEG69505"/>
        <property type="gene ID" value="SAMN04489712_10990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="221"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="284"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG69505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="444" mass="46621" checksum="D3DA1A806D2656DC" modified="2017-01-18" version="1">MSIVLGVVALFVLTAATGYFVAQEFAYVAADRAALTNAAEQGDGKARRALEVMGRLSFMLSGAQLGITVTGLVVGLLSKPALADLLRPLLGWMGVPDGAVGAIAVAVGFAIATVVQMVMGELIPKNWALARAEAIARVLASSTLAYLAVAGPVIRLFDNTANRLLRAVGIEPAEELHHGATLEELSDIIGESHRAGHLPADLSAVLERALTFGERTADEAMVPRPKVITVAAGDTVAELTEHVRRSGHTNYPVYGADVDDIVGVAGVRELADHTLTPDTPVGRIARPALLVPGSQPLYGVIERMRETGEEFACVVDEYGGLAGILTFEDIAEELVGEISDENDVAETASAAVADGDWTVDAALRIDEVAALTGLELPEDEVYDTLGGLVISRLGRLPRPGDRVVVELDPTEGQLGEAEIEVLSVARRVPREVRVRVLATAGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CBR2</accession>
    <name>A0A1H6CBR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70384">
        <property type="protein sequence ID" value="SEG70384"/>
        <property type="gene ID" value="SAMN04489712_109166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="82" mass="8844" checksum="9AF77FFC817498BD" modified="2017-01-18" version="1">MTYKPFLAERALAQLGGFPVDALGALAQVMAVVCEDPRDPLVTLPTDDPEIRRAPFGGHGLVTFLIVEPAQVVRITDITWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJH7</accession>
    <name>A0A1H6CJH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quaternary ammonium compound-resistance protein SugE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72835">
        <property type="protein sequence ID" value="SEG72835"/>
        <property type="gene ID" value="SAMN04489712_11039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG72835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="10661" checksum="91B581FBC645C4DE" modified="2017-01-18" version="1">MAWILVVCAGLLEVAMALCLKLSKGFSQPLPSVGFGVFAVASFGLLSLALRELEVGTAYAVWVGIGAVGTAVVGMVALHDDASPLKLAALAMIILGVVGLNLAGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLP6</accession>
    <name>A0A1H6CLP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase inhibitor I9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_110101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73366">
        <property type="protein sequence ID" value="SEG73366"/>
        <property type="gene ID" value="SAMN04489712_110101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294997" evidence="6">
        <location>
            <begin position="29"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="141"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG73366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="41438" checksum="FF526CD7E55403AE" modified="2017-01-18" version="1">MRVTPRRVLVVVTVATSVGVAVTVPGLAGPEQVPIQVAANGTPVPGQYIVTLKPGASTSTEAGKVRATGVKRFDGVLNGFSAKLTGSQLDKLRRSDKVAAIEQDQVVKITTVQRTPLPWGLDRIDQRSAKLSKSYTYRSTGKGVHAYVIDTGITANHPQFGKRARSVWAAPQFNGDGRDLNGHGTHVAGIIGSRQYGVAKAVQLRSLRVLDRYGQGSMSDVIAALQWLRTNAQKPAVANLSLAGNKSNAANEAVSALSRSGVPVVSAAGNGDGATRGYNACRFSPASAPLTIVVGATTVTDKRAVWSNFGECVDIHAPGYGIRSTWRNGSSKVLDGTSMATPFVAGTAALYLSRHPRAKFSDVRRWLVTNSTKGKITGLPAGTRNRLLFKGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMH0</accession>
    <name>A0A1H6CMH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase, PHB depolymerase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73967">
        <property type="protein sequence ID" value="SEG73967"/>
        <property type="gene ID" value="SAMN04489712_110175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="358" mass="37532" checksum="F142AA07EABDFB29" modified="2017-01-18" version="1">MSGARYAVTLAGMDAITGRGAAPRGLRPSNVVALLVALAAFVGGWLAGGPVARAAVGFQEVTGFGSNPGNLRMFTYVPSNGQSGAPVVVLFHGCGGSANGLDTATGWRKYADAYGFTLVMPEQKPENVGSGGIVPHKCFSAWNAEDRTRAGNGEARSVIQMVDHMKREYGADASRVFVTGYSGGGAATNVMLAAYPDVFKAGAVFFGMAYGCADTEDAYFTTGLFGQCSGPLNRSTPQQWGDRVRSAYPGYSGPRPRVQIWHGGSDRLISPRSLDYQRDQWTNVFGFGRTPTSTTTPAPGVTKSVYGNGSVETYLIDGMGHEPPIDPGTGIQNCGSRGSGHDSLCGPYYASHFFGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNE8</accession>
    <name>A0A1H6CNE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative drug exporter of the RND superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_110233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74502">
        <property type="protein sequence ID" value="SEG74502"/>
        <property type="gene ID" value="SAMN04489712_110233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295035" evidence="7">
        <location>
            <begin position="36"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="188"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="512"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG74502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="722" mass="74487" checksum="A02DB1421472BCF9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRS8</accession>
    <name>A0A1H6CRS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75701">
        <property type="protein sequence ID" value="SEG75701"/>
        <property type="gene ID" value="SAMN04489712_11173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7293" checksum="C3F91775B1B95DCF" modified="2017-01-18" version="1">MYGWIWRRLPGQGLVKVLVAVGLVAAIVLLLWYAVFPWAESKIQFDQNTVEHGGAPAPAGTSGPDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSP7</accession>
    <name>A0A1H6CSP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein CrgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crgA</name>
        <name evidence="4" type="ORF">SAMN04489712_11171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CrgA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75683">
        <property type="protein sequence ID" value="SEG75683"/>
        <property type="gene ID" value="SAMN04489712_11171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00631">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009619">
        <property type="entry name" value="CrgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06781">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG75683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="85" mass="9390" checksum="2B0A87202FB7789B" modified="2017-01-18" version="1">MAKSKVRKKAVYTPPQKSQKVEVSPRWLVPTMLTLWLAGLAWIATFYVTASTGTNVPVMTDLGNWNLGIGFGAIILGVVLSTRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT87</accession>
    <name>A0A1H6CT87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76007">
        <property type="protein sequence ID" value="SEG76007"/>
        <property type="gene ID" value="SAMN04489712_111108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295222" evidence="2">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="170" mass="17587" checksum="7731A0BB48778140" modified="2017-01-18" version="1">MRRLVIITATAAVTASSGLLPAQADVTRTPAPARTGTAGPCPTASGVTVVVDYQELGGATEVRCAPGAQPSGLAALENAGFTVTGTQRWGKAFVCRINGKPTAATEPCIDTPPASAYWSYWHAPNGGSWTYSSLGAGSYVPPQGSWEGWSFSKNKTPTTNPPPRVTPVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0T5</accession>
    <name>A0A1H6D0T5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_112148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78971">
        <property type="protein sequence ID" value="SEG78971"/>
        <property type="gene ID" value="SAMN04489712_112148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="8">
        <location>
            <begin position="28"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="9">
        <location>
            <begin position="254"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG78971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="37146" checksum="B4B84629A57C253F" modified="2017-01-18" version="1">MTIVPSGSPQALTPATAYFRDALPKRPLRLGGRTSHLARAYARRVIDTLTSVVPGLRVEYVPITTSADRYKGDLSELGGKGLFMKEIDKALMVGEIDAAVHCMKDVPGDVPLPKGLVFAAYMQRDDVHDAVVFPEGSKYSSIEELPTGARIGTSAVRRKAQLLRWRPDLNVQRFRGNVIPRLTRLDEDREVDALVLARGGLAAVGMDHRISQVVAMEKMCPAIGAGVVGVQCRKADEGIVELLQMIDHAETRTHILAERTMLHALQGHCNSPIAGHCHTTQDGQLSLIGMVFSRDGATFAYAHEWDTPDHAHELGAYVAATLTRKNARSIIAGTRLHQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1J1</accession>
    <name>A0A1H6D1J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA topoisomerase IB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_112166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79087">
        <property type="protein sequence ID" value="SEG79087"/>
        <property type="gene ID" value="SAMN04489712_112166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.66.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035447">
        <property type="entry name" value="DNA_topo_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55869">
        <property type="entry name" value="SSF55869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topoisom_I" evidence="5">
        <location>
            <begin position="81"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG79087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="38257" checksum="EDF563721D20C115" modified="2017-01-18" version="1">MELQRSDPAEPGISRRRCGRGFRYLGPDGRPVGPAEVARIKDLVIPPAWQDVWICPDPDGHIQATGTDAAGRRQYLYHPQWRVQRDREKHDRVLDFAEALPRVRKQVTEHLTGRDFTRERVLAAAVRLIDLGFFRAGGEEYAEENGTYGMATVLREHVTCRRGGEVIFEYPAKGAKDRYQAVAEEDVCKVVSGLKRRRDDGPELLAYRTPGGWHDVTAGDINEYLREISGGDFTAKDFRTWHATVLAAVGLAVSTPAATSESARKRAVSRVVQEVADYLGNTPAVARASYIDPRVIELYERNVTIAPALTELGHDADFGELATQGRAETAVLKMLRRHQNDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1X1</accession>
    <name>A0A1H6D1X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79379">
        <property type="protein sequence ID" value="SEG79379"/>
        <property type="gene ID" value="SAMN04489712_112207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="179" mass="19750" checksum="08C81856859E245D" modified="2017-01-18" version="1">MGAQYEYPEKLKELGISEQDFGEMDPDLQRWYYLEYHGAAARPQDIHFPRGTAPSGDFKFEAGDGFDVKPQKLRDLADALESDLNELKPLLSRIQSEGLISTSHVGEWPSGAEFARVASNTQTGFNQYLTDVVAGYNGVISRLRTTADNYDKAEKKTNEQANSVNTNGPSPTTNGNVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D571</accession>
    <name>A0A1H6D571_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical S-adenosyl methionine domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80128">
        <property type="protein sequence ID" value="SEG80128"/>
        <property type="gene ID" value="SAMN04489712_11320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="6"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG80128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="313" mass="34802" checksum="0037108D16E613F5" modified="2017-01-18" version="1">MGMPDSPRVPVETVNFHLWQPCNMSCRFCFATFRDVRRTVLPEGHLERADAERVVAGLAEAGFTKLTFAGGEPLLCPWLANLVTLAHRLGMVTSVVTNGSLLDEAALARFHGVLDWITVSVDSPRPQTLQLLGRTTAGRAIGGDEYLALFRRIRELGFRLKMNTVVTAGNWREDMADFVIEARPERWKVFQALPVAGQNSGRVDPLLTTLEQFEDFVSRHLRVEPAGIRLIPEDNDVMTGSYAMVDPAGRFFDSVDSRGYTYSEPILRVGVHRAISQVRISRVKFLVRGGLYDFTPEPEPVAGLLAADESGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6B3</accession>
    <name>A0A1H6D6B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80880">
        <property type="protein sequence ID" value="SEG80880"/>
        <property type="gene ID" value="SAMN04489712_113169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="86" mass="9415" checksum="72341950BD597E45" modified="2017-01-18" version="1">MIHLSRLSRRHLCRPALRGPAERVVIEVWLTGLAGLVLNGYPDARERPASAWSLTRRATVQALPERRPATVPADAPASPDERAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6J9</accession>
    <name>A0A1H6D6J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzoate membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80901">
        <property type="protein sequence ID" value="SEG80901"/>
        <property type="gene ID" value="SAMN04489712_113173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042925">
        <property type="term" value="F:benzoate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004711">
        <property type="entry name" value="Benzoate_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30199">
        <property type="entry name" value="PTHR30199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03594">
        <property type="entry name" value="BenE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00843">
        <property type="entry name" value="benE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="401" mass="39619" checksum="52B0FC937EB62F73" modified="2017-01-18" version="1">MGRTTQPVLAGLVTALVGFASSFAIVLAGLRAVGADPRQAASGLLALCVAAGVTAIWLGLWRRMPISIAWSTPGAALLVSTGTVEGGFAAAVGAFVVCGLLIAITGLFAPLGRWIAAIPQPLAAAMLAGVLLELCVAPARALAEVPLMAVPVVLTWALLSRFAKAWAMPAALVVAVVAIALDGADGLDGAALAPVVEPTVPQWSLPAMVSIAFPLYLVTMASQNVPGMAVLAGYGYRPALPGILVGTGLGSAAAAPLGGHAVNLAAITAALAAGPDAHPDPGRRWIASVTAGATMIALGLGAGLATALVLASPPVLIEGVAGLALLGALGSAVTTAIADPTRREAAVVTFAVTASGVTIAGIGAAFWGLLAGAFMLLLHRRRPAGDESADREPAEVAVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7D0</accession>
    <name>A0A1H6D7D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81230">
        <property type="protein sequence ID" value="SEG81230"/>
        <property type="gene ID" value="SAMN04489712_1143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG81230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="479" mass="50078" checksum="A7EE601E331654AF" modified="2017-01-18" version="1">MTAETTSAPPDSEAVYPRRWAALVVLLVAFMLDLLSVTIVNVGLSSIQRDLGASPTDLEWISAAYLLSFAVALITAARLGDLRGRKLIFLLGIIGFAVTSLWCGIARSPAELITARVFQGLAAAAIAPQVMSILYTIFTGRERATVFGTFGLVSGVTQAGGLILGGALITADIGGLGWRTIFLITVPVAVALIPLAIWLVPESRVPGGTRPRWAATGVLVVGLVAIVFPLLEGRAYGWPVWCWLCLAAGILAVLGLAVFEHRDPGRRAGALLPVALFRNRTGAGGLLVLLLAFSGFSGFMMIFPLWLQDGQRFSALEAGLVSIAFAAGGLVMAMLTGRLTIRFGRFIVLAGCLLSVAGGIALLTAVHATSPTVNSWSLVPGLFALGVGMTFVMPPLTTLFLSAVPPEYAGSASGVWTTGQQFGSAVGVAAFGTVFFTVLDDHEGYQTAFTTSTIAVLAALLISAALCFILAPNRQQQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9E2</accession>
    <name>A0A1H6D9E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_114167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81890">
        <property type="protein sequence ID" value="SEG81890"/>
        <property type="gene ID" value="SAMN04489712_114167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="29111" checksum="69855B0C8AE50B26" modified="2017-01-18" version="1">MHHVIIGCGNVGMELARRWTAAGHRVTGTTTTGARVPELKEVCSSVVVLRGSDRAAVERTVRGADAVVLTVSPRITRSFDAAQRVEEYADTLVASARTAASAHPRVVFTSSTSVYGAGNGPEVDESSPTTDDPDASPQSFIAAERAVLATQRGAVVRIPDVYGHPRDIDYPARVRFAHEQLGGSVPFSAEALLYRIDYRDAAAALDFVVSRELTGIFNAVPDTSVPPANAEAFHAVCRAEGLPDLRFRGEIKTPVVPVTSARLRGAGFRFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAB5</accession>
    <name>A0A1H6DAB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_114137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81763">
        <property type="protein sequence ID" value="SEG81763"/>
        <property type="gene ID" value="SAMN04489712_114137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="22109" checksum="13E4DB337A02A84F" modified="2017-01-18" version="1">MTAAVSPPTRKDAARNRARLLEAAEQLFSTEGLSVTLKDIAARAGVGVGTVYRHFPTKGDVLDALFADRLACATESARAAAADADGWRGLVRYLEDAMDMQANNCGLRGLVMETEPSSPLVVKTRQEITVLVQQMVAKAREQGTLRPDFDATDLTFVQVALAAIMDATRDTDPDLYRRHLKLFLDGMRSAGHREPLEARAATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEC9</accession>
    <name>A0A1H6DEC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83584">
        <property type="protein sequence ID" value="SEG83584"/>
        <property type="gene ID" value="SAMN04489712_11630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="119" mass="12998" checksum="49369351320ECA77" modified="2017-01-18" version="1">MHATPRVGNLAIDCADLGAMATFWGGLLGMKVTYRKDTWLDLEPLGAEGPVLSFQKVPEAKSGKNRLHLDLYVPDVDAAGARARELGGSPAGGRQDRPDMSFQIWRDPEGNEFCLVTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEJ1</accession>
    <name>A0A1H6DEJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="6" type="ORF">SAMN04489712_115152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83125">
        <property type="protein sequence ID" value="SEG83125"/>
        <property type="gene ID" value="SAMN04489712_115152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG83125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="45" mass="5403" checksum="5D6B5A4401A66D1A" modified="2017-01-18" version="1">MSKRTYQPNNRRRHKKHGFRLRMRTRAGRAILSARRRKGRASIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEJ3</accession>
    <name>A0A1H6DEJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske [2Fe-2S] domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83847">
        <property type="protein sequence ID" value="SEG83847"/>
        <property type="gene ID" value="SAMN04489712_11681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="46"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG83847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="458" mass="52429" checksum="3885312D68F46325" modified="2017-01-18" version="1">MSETVENVRATAAAEALSEPLTIPVAAYLSEEYARAERDKLWRKVWQQVGRVEEIPAVGDFLTYEILDDSLLIVRTAPDRIRAYYNVCSHRGRRLVDTPSGARDARGRGRRFVCGFHGWQYDLEGHCTHVPERADWQGCLTDERTGLKQVQVDTWGGWIFINMDPECEPLRDYLEPAATLLAPFQLERFRYRWRRWLVFDCNWKVALEAFNETYHVPYTHPEFIPFGSFLGWSRVQGRHSNIGFEAPKGLEENQGKLRIGGGVDARVSTAEMQNFIWENANTNTTETLVEVANRLVTELPEGTPPDQVAKYWLETARREDAERGVIWPTVAPEAVAESGTAWQIFPNFQIGHGQNNMLCYSARPYGYDPDKCVFEVAVYQLYPPGEEPETEWVHTPQDDPDWRTVLPQDFSNMAAVQQGMKTRGFSGPKPNPYRERATVNLHHNLAKYMGTGEPRKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFT6</accession>
    <name>A0A1H6DFT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83613">
        <property type="protein sequence ID" value="SEG83613"/>
        <property type="gene ID" value="SAMN04489712_11636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013630">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038576">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013691">
        <property type="entry name" value="MeTrfase_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08421">
        <property type="entry name" value="Methyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08484">
        <property type="entry name" value="Methyltransf_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_13" evidence="1">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_14" evidence="2">
        <location>
            <begin position="252"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="422" mass="46381" checksum="6488ADE2D0D1661E" modified="2017-01-18" version="1">MNTLDSARQVTACRVCGGVDWQDVVSFGSVPPANAFLEPAPAYEEDRYPLAVISCRSCRLMSLTHVVDPEILYRTYAYATPASDTINDHMRYVADVCRTRFDLPAGGFVVELGSNTGVQLRAFQEAGLRVLGVDPARNLVEVAERHGVRTLPEFFDADTARAVARDHGRADLVLGRHVFAHIDDVAGVLTGVRELLAPGGVFAIEVPWALDMVDDLEFDTIYHEHLSYFLVRTLVTLYERHGLRVLDVERLPVHGGSILVFAGLESGPWRPRPSVRELCDREEAAGLFGDDAYRRFAERVETTRRELRDLIRGQVAEGRRVAGYGASAKGVTLLNVCGLDGGELEFCSDTTPLKQGKVMPGVHVPVCSPKRAAQDPPDLYLLLAWNYAEEILAKEAGYLGRGGRFVIPVPRPLIVSGETRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGS4</accession>
    <name>A0A1H6DGS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84430">
        <property type="protein sequence ID" value="SEG84430"/>
        <property type="gene ID" value="SAMN04489712_1172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="211" mass="22365" checksum="D9902DC418022EF0" modified="2017-01-18" version="1">MNDGEAPDLRTRHKQATREAIGAAALRLAIEQGPNGLALVRVNDIAAAAGVSPRTYNNYFSSREEAICAFQADRARRLGAALRSRPAEEPLDQAITAAVVGHFTTPEPDRAGLRMIMSTPELEGEALKAFTMAEGPLAEAIAERTGTDPARDLFPQVTAAAVAGAVRVAGRCWLSPGNTDPFAAVLRRALAHVLPATRSDGPHEPPRETQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJC6</accession>
    <name>A0A1H6DJC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84923">
        <property type="protein sequence ID" value="SEG84923"/>
        <property type="gene ID" value="SAMN04489712_11793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG84923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="411" mass="46033" checksum="21A74A005B7E1CAC" modified="2017-01-18" version="1">MSAPHAFPLEPTPIHVPGEVLDDLRARLTLTRPPLDEGNEDWSYGVPDSYLRELVAYWRDGYDWRKAEAAINAYEHYQVSVAGVPVHFMRKPGRGPRPIPLILTHGWPWTFWHWSKVIDPLADPAAFGGDPADAFDVIVPSLPGFGFPGPLTGFPDVNFWKVSDLWHTLMTETLGYEKYAAGGCDIGGIVSSQLGHKYADELYGIHIGSGLPLDFFTGPRAWDFARNRPLTDNQPADVRARIIELDHRSACHLAVHMLDGATLAHGLSDSPAGLLAWLLERWNAWSDNGGDVESVFTKDDLLTHTMIYWVNNSIATSMRYYANANRYPWAPAHDRTPVVQAPVGLTFVTYENPPDIHTAGERVQAFKSGPQGDWFNHVNVNAHDHGGHFIPWENPDAWVSDLRRTFHGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DK66</accession>
    <name>A0A1H6DK66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, DHA1 family, chloramphenicol resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85501">
        <property type="protein sequence ID" value="SEG85501"/>
        <property type="gene ID" value="SAMN04489712_11819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG85501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="39211" checksum="280AF0D769D9CE2C" modified="2017-01-18" version="1">MPLPLYLLAMAVFAMGTSEFMLAGLLPDIASDLDVTVGTAGMLTSAFAIGMIVGAPLMAGLARNWPGRSSLLGFVLVFLAAHAVGAATTSFAVLFATRVVAALANAGFLAVALTTAATLVSPDKKGRALAALLSGTTVATIAGVPGGSMLGTLLGWRAAFWAVAAVCVPAAIGILKGIPARRVQQDAADGPALRSELAQLKRPRLLLVMLLGALVNAATFGSFTFLAPVVTDTAGLGELWISVVLVLFGLGSFAGVTVAGRLSDQRPGLVIAAGGPLLLIGWPALAVLADKPVALLTLVLVQGALSFALGSTLITRVLYEAAGAPTMAGSYATAALNVGAALGPLIAATTLSTTAGDLGPLWASGLLVAVALLIAFPLRGVIAAGRSSEVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLD7</accession>
    <name>A0A1H6DLD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanases superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85526">
        <property type="protein sequence ID" value="SEG85526"/>
        <property type="gene ID" value="SAMN04489712_11824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="33"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG85526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="579" mass="61400" checksum="0F6DAD214179A71B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLM2</accession>
    <name>A0A1H6DLM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_118135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86031">
        <property type="protein sequence ID" value="SEG86031"/>
        <property type="gene ID" value="SAMN04489712_118135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="245" mass="26615" checksum="5BC7652B42CAF262" modified="2017-01-18" version="1">MQIGDLGRVLVIIPTYNERENIEPIVGRVRRAAPQVDVLVVDDASPDGTGALADALAASDDQVKVLHRTGKDGLGAAYIAGFRWAFEHGYDVLVEMDADGSHQPEELGRLLAALAEADLVIGARWVPGGEVRNWPRSRAVLSRGGNAYARLMLNVPLHDATGGYRAYRATALQKIGLDGVESRGYCFQIDLALRAVRHGLRVVEVPITFVEREHGASKMSGDIVAEAMWQVTRWGIAGRLGRDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLX5</accession>
    <name>A0A1H6DLX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86189">
        <property type="protein sequence ID" value="SEG86189"/>
        <property type="gene ID" value="SAMN04489712_11912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="29835" checksum="88A6812C93098606" modified="2017-01-18" version="1">MTERHVTVEQEGRVGLVFLDRPDRRNSYTPLMALQLQEALVAFDADPEVSVIVVSGRGEHFGVGADLDMNWRDEKTHGVETLTEPEKAPWNLSTPIIAAINGDAIGVSLTWAMQADIRVVADSARLAFSFNRVGIMPDRGSTWLLPRLAGFGVAMDLLLTGRTIDGTEFERRGLATHIAAPEDVLKVAVELATDMAERCAPVSMTATKRLMYEFLESTDRVAAYNRERRTLTWIRTCGETLRGIAAFKEKRVPEWGTTKHTRIPAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPE3</accession>
    <name>A0A1H6DPE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase components of ABC transporters with duplicated ATPase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_119134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86643">
        <property type="protein sequence ID" value="SEG86643"/>
        <property type="gene ID" value="SAMN04489712_119134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="340"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG86643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="544" mass="59209" checksum="A2A2EBCFB22F5EDD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPJ0</accession>
    <name>A0A1H6DPJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87064">
        <property type="protein sequence ID" value="SEG87064"/>
        <property type="gene ID" value="SAMN04489712_12061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG87064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="35899" checksum="1E244E82702E2335" modified="2017-01-18" version="1">MFGPDFTFLGVDRCDLTDPESFADADIVILGAPFDGGTSARSGARFGPKALREACYLPHDGSRPSLALRVDGLKDLRVYDAGDVECYSGDVETSIANIEEAVHTIASSGAIPLVLGGDHTLALPDARGVARHHGFGQVSMLHFDAHADTGNIEFGHLYGHGQPMRRLIESGAIRGDRFLQIGLRGYWPEPETLSWMAQQRMRSYEMTEIVSRGLETCLSEAFAIALDECEGVFLSVDIDVCDPGHAPGTGTPEPGGLSARQLLDSVRRICYELPVVGMEIVEVAPPYDHADITAYLGNRVVLEALSGMARRRHDAEHGTTWDPTRPLLDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPL0</accession>
    <name>A0A1H6DPL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_120108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87307">
        <property type="protein sequence ID" value="SEG87307"/>
        <property type="gene ID" value="SAMN04489712_120108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="109"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="39073" checksum="073F7CE8AF56F36E" modified="2017-01-18" version="1">MTTARPAETLARTFTAIEADGTYTLDARPAGDGRLLAPLDRPLLGWTRKPHGWCRDEACLPVHRAAAAETPEGVDVAAFAELVGRLAVIDEDERAVAFAEGAGPFAAGGLTAERAPDFTLDGVSLADFRGRKVAIVFWASWCGCRYDLPAWQERHEALERHGFTVLSVALDRAAEDARPWIAEAHAGRPSPHPALVDAEGLVAERYNVINVPTVVWVDEQGRIARPQDTQTATDLFRSMNGLDSARSLEALRRWVVDDDAGLDAEQVREHLRVPTMQERRARAHARLAVWLARRGRAQAARRHLDAAAALAPHDIAIRRGLMPLTGEDPFGDAYFALRTELEDAGIPLYRPLTPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQN4</accession>
    <name>A0A1H6DQN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine/D-amino acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86895">
        <property type="protein sequence ID" value="SEG86895"/>
        <property type="gene ID" value="SAMN04489712_12029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="36"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="464" mass="50977" checksum="72C3248314215BC3" modified="2017-01-18" version="1">MNVLKALAEAEPVPYWLTDPARPEPAPALVGPVTCDLAVVGGGYTGLWTALLAKERDPALDVVVLEADRVGGAASGRNGGFCSASLTHGLGNGLERWPDELATLERLGRDNLDGIERTLARYGIDAEFERTGELDVATEPWQLDDLIEAAEAARRLGHDPVLLDAGQVRAEVDSPTYVGGLWDTGGTAMVHPAKLAWGLADACRSLGVRVYERTPVRSLTDQGGRLRLGTSYGSVSAARVALGTGVFPPLLKRLKHYLVPVYDYALMTEPLTDAQLASIGWRNRQGIGDSANQFHYYRLTADNRILWGGYDAIYHYGNELRTELEQRPATFVKLARHFFQTFPQLEGLRFTHAWGGVIDTCSRFCAFYGTAYQGRLAYAAGYTGLGVGATRFGAAVMLDLLSGSRTERTRLRMVRSKPIPFPPEPLRYGAIQMTRWSIARADRNEGRRDLWLRTLDRFGLGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWL1</accession>
    <name>A0A1H6DWL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89651">
        <property type="protein sequence ID" value="SEG89651"/>
        <property type="gene ID" value="SAMN04489712_12417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG89651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="718" mass="79703" checksum="CEF3DC7F82AF4E3B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXC1</accession>
    <name>A0A1H6DXC1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89353">
        <property type="protein sequence ID" value="SEG89353"/>
        <property type="gene ID" value="SAMN04489712_12374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG89353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="16337" checksum="1C3B75B6D60C408F" modified="2017-01-18" version="1">MRPGARLGVDVGSVRIGVARSDPRGVLATPLETVRRGKGDLDRIAELVAEYEAVEVIVGLPTSLSGRSGPAADQARRFAEALAGRLSGLLPDDGVRLYDERLTTVTAETGLRQSGVRGKARRQVVDQAAAAVLLQAALDGERLTGRPPGETVRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYM6</accession>
    <name>A0A1H6DYM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3alpha(Or 20beta)-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90452">
        <property type="protein sequence ID" value="SEG90452"/>
        <property type="gene ID" value="SAMN04489712_12642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28203" checksum="EE07FCA7FEC89029" modified="2017-01-18" version="1">MPDPGRRILERTSLDGKVAVVTGAARGMGAEQARSLAARGSAVLLVDVDADRGRALAAELEEHGSAVAFTPADVSDPAHWQTVRRAVLDRFGAVHVLVNNAGVVGHRRIGKISRADWQRVMDVNLKGAFLGMKTLAPDLRDAGGGSIVNVSSVAGLDQHPDPSYTASKWGLRGLTKTAAQEFGPWRIRVNSIHPGYMDTPMNDFASPELRAAKASLLPLGRPGEAWEAGELVAFLASDAAAFITGAEIAIDGGWTSGAQATEARRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E255</accession>
    <name>A0A1H6E255_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_13025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91700">
        <property type="protein sequence ID" value="SEG91700"/>
        <property type="gene ID" value="SAMN04489712_13025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG91700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="432" mass="47329" checksum="741C9721F547F481" modified="2017-01-18" version="1">MMMTDVKAGAQVAKPDKPADQPGGVDPELIGRLVAQAREQGMELTGEGGLLAELTKRVLESALEGELTDHLGYDRHDAAGDGSGNSRNGKRAKTVITDVGPVTIEVPRDRDASFEPKIVRKRQRRLSGVDEMVLSLSAKGLTHGEISAHLAEVYGAQVSKQTISTITDKVIDGMTEWQNRPLDAVYPVIFLDAVHVKIRDGQVVNRPIYVALAVTGEGTRDILGLWAGDGAEGAKFWLHVLTELRNRGVGDVCMVVCDGLAGLGDAVTATWPRTIVQTCIVHLLRGSFRYASRADWAAIAKALKPVYTAPTEEAAMERFMEFTEAWGAKYPAIVRLWENAWAEFVPFLNFDVEIRKVVCSTNAIESVNARIRRAVKARGHFPNEQAALKCVYLAIMALDPTGKARKRWITRWKAALNAFDITFDGRLSAARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2D9</accession>
    <name>A0A1H6E2D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91075">
        <property type="protein sequence ID" value="SEG91075"/>
        <property type="gene ID" value="SAMN04489712_12829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="28815" checksum="9FCDA53752414EFE" modified="2017-01-18" version="1">MTRRLLPVLADSGPVVVLAAIAAAGSFTHIRDTAREHGQHGWMAWAIAVCIDLTCVMAARERQRDKRTARTARPLSWPTCVLIGGILLSLAANLAQAQPTVWGWVTAGTPATAFLVAVSMLERRATHRPAARPDALAPDGLAVPPSFGRPADSSPSSSSPPVPPVPAVRDGARPELAAPDPAPVEGGQTEIPLPAAAPAAPSRQDDSGRPAPADSARPAGSASSAGPLVEFARRVADEHHTKHGRPITRDALRARLGVSNQLASELLRQLRDQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2W8</accession>
    <name>A0A1H6E2W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91877">
        <property type="protein sequence ID" value="SEG91877"/>
        <property type="gene ID" value="SAMN04489712_13111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="53" mass="5328" checksum="8CD259412D9CB7C0" modified="2017-01-18" version="1">MTPPRATVTGPVCVDAVDDLVVATVDGPDPGRTDALPATPVRAGAIPLPFTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E481</accession>
    <name>A0A1H6E481_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92121">
        <property type="protein sequence ID" value="SEG92121"/>
        <property type="gene ID" value="SAMN04489712_13231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="52" mass="5007" checksum="701EB2BE383309C3" modified="2017-01-18" version="1">MVAAAVPVIAVLRDDSETGGQGGLVVLATSREQAAALAGAAGTRLSVTIVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5N5</accession>
    <name>A0A1H6E5N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92205">
        <property type="protein sequence ID" value="SEG92205"/>
        <property type="gene ID" value="SAMN04489712_13256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="412" mass="45047" checksum="C2E6EE6FCCAF825C" modified="2017-01-18" version="1">MSDDRRKRFGAYLARMRRKANKSQRQLAEMLCRISGTASVTRNEVSRWERGERVPTVWLPALATALGIHLDELERAAEHARGDDIQNGTPSPAETLAILLPDHGEHLGPLASHVGRRIGMSTADGLAARAHGLRLADDVIAGGDLIAPAFRELNAAIRLYRETTHTEEVGRALLASIAEMAQIAGWIASDAGQHDQAERAYRLGVSAAREAQDSTLAGNLAGSLAYQLSNTGQEDTGLSLAQAALEEAGPDAPGKTRALYLDRVAWAHTKKGQNQQAMRALGEAHEALTEDGADEAPTWAYWVSAEELDVMDARVYTELHKPLRAVPLLQEVLSRYDATHARELALYLSWLAVALADANEPEEAANTTRRILDLTSDLTSDRTNQRTRVVLAKLEPFRHVPEVREILDEHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E880</accession>
    <name>A0A1H6E880_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93156">
        <property type="protein sequence ID" value="SEG93156"/>
        <property type="gene ID" value="SAMN04489712_13729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046156">
        <property type="entry name" value="DUF6158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19655">
        <property type="entry name" value="DUF6158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="75" mass="8640" checksum="857A3C65A9CCFAC8" modified="2017-01-18" version="1">MGIGVEPALLNDSDLMRELNNLYETRMDALRHASDHALAEHTRRTAELEAEYIRRNPAREIDPERLREGARARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9R9</accession>
    <name>A0A1H6E9R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93575">
        <property type="protein sequence ID" value="SEG93575"/>
        <property type="gene ID" value="SAMN04489712_13934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="105" mass="11730" checksum="5B0BBB60A28628E9" modified="2017-01-18" version="1" fragment="single">MVPYAAMLDIPRPVVAYVARLLAAHRRRIGTPRGSRALGPFRQAMFVLRWFRHATDVPALARDAGISQATGYRYLHEGIDVLADQAPDLHEVLQRCQADGLTHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9Z8</accession>
    <name>A0A1H6E9Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94678">
        <property type="protein sequence ID" value="SEG94678"/>
        <property type="gene ID" value="SAMN04489712_1504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296672" evidence="1">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="134" mass="13724" checksum="DCC4165FEE980C0E" modified="2017-01-18" version="1">MRVRTTRLLGVLAIGGVMLSSTACLPGLDGVTGGGEKTAACNAMTQEISSVSTRATQNLSNPTAMAQIYSDAATKVRAEGQKAGGDVQEAAGQVADDLEELAQLLRDLDSGNIRVPDTSKLTTSGARLQQACAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB51</accession>
    <name>A0A1H6EB51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000058">
        <property type="protein sequence ID" value="SEG95000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95000">
        <property type="protein sequence ID" value="SEG95000"/>
        <property type="gene ID" value="SAMN04489712_1582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296748" evidence="2">
        <location>
            <begin position="29"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG95000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="22598" checksum="3BB058CF0F71359A" modified="2017-01-18" version="1">MASVPRMPFAPVVAVALLAAGCAGPASRVAPPPSFEHDAPTLLAAGTGNLEGSTSLRLTLRLKDPGGDGRKAHRLDMSGVWDVRQGSGRMDGTLRGGRATVLSVGGVEYVSLPADLRRKTGRQWLRGAVGTRTFGDFPDVHRVAMILRTSQRPALAAPAGGHGGPRPRPIRTCRTAGRGSGIAAETAAPTLSGLDVLPDSRPGGRKGCRDSPGFSVKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECN5</accession>
    <name>A0A1H6ECN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000051">
        <property type="protein sequence ID" value="SEG94779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94779">
        <property type="protein sequence ID" value="SEG94779"/>
        <property type="gene ID" value="SAMN04489712_1515"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01358">
        <property type="entry name" value="DAHP_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG94779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="449" mass="49305" checksum="C4B0501A5D57CD68" modified="2017-01-18" version="1">MSITSATGELDAWRALPAAQQPEWDDPEEVRAVTAELAQAPPLVFAGECDQLKDRLADVVRGEAFVLQGGDCAETFTGSTADAVRNKLKTLLQMAVVLTYAGSVPVVKIGRMAGQFAKPRSKPVEVRGGVTLPAYRGDAVNGFDFTPESRRNDPRRLLQAYHCSAVTLNLCRAFTKGGYADLRQAHAWNQDFVASSPAGRRYEQLAWEIDRALAFMKACGADPEEFHGVEFYSSHEALLLEYERALTRIDSRSGLPYDVSAHMVWIGERTRALDGAHVEFASRIRNPIGVKLGPTVSADEALALIDRLNPDGEPGRLTFITRMGAGRIRDALPSLIEKVSQNAAPVAWICDPMHGNTFEAPSGHKTRRFDDVVDEVAGFFEVHRALGTHPGGIHIEFTGDDVTECVGGGHEIVEDDLHQRYETACDPRLNRGQSLDLAFMVAEMYRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S4H1</accession>
    <name>A0A1H5S4H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA 2-thiouridine synthesizing protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45360">
        <property type="protein sequence ID" value="SEF45360"/>
        <property type="gene ID" value="SAMN04489712_10172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="3">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF45360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12769" checksum="A0100197ABC59FE3" modified="2017-01-18" version="1">MMFRGRGTRGSGRTTGRGRRAAGAPVQPAPVEPAGPAEPVGPPPVLVIDAIGRKCPIPIIWLAERIREVPVGEVVAVLADDVAARTDVPAWCRMKSQEFVREETLSRGWAFHIRRCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S5V7</accession>
    <name>A0A1H5S5V7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SAMN04489712_10193</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46043">
        <property type="protein sequence ID" value="SEF46043"/>
        <property type="gene ID" value="SAMN04489712_10193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045603">
        <property type="entry name" value="QcrA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19297">
        <property type="entry name" value="QcrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="17">
        <location>
            <begin position="291"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SEF46043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="374" mass="39963" checksum="7149D85C49FA6415" modified="2017-01-18" version="1">MSDNNLGSNEPMEPGDAAHARNQSPKRVIGTPEQGGRLLATAESEPAPHGAGAELDEAAAKRAERIVALFFLLAALGSVGFIAAYVWSGQQGPNGMHGIEDARASNYALGVAMTVAMLAMAIGVTIWVRRLMTSKQIVQQRGPLRSDEETRAEFEAAFLEGAGDSAVTKRPLLRRTLLLAAAPLGLAPLVLLRDLGPLPEKRLRHTFWGPAVTEAKKHGKQGVRLVVDGAPTQALKVSDFATPGSMITVLPEGIEESHHALNEIAKAVTILINVPADKFKPVKGRENWHVGGIVAYSKICTHVGCPAALYEQTTHHILCPCHQSTFDATDGAKVIFGPAARPLPQLPLSVDKEGYLIATDDFPEPIGPSFWERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S732</accession>
    <name>A0A1H5S732_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase, NADH-binding subunit (Chain F)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46416">
        <property type="protein sequence ID" value="SEF46416"/>
        <property type="gene ID" value="SAMN04489712_101103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="6">
        <location>
            <begin position="311"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF46416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="489" mass="50579" checksum="AFB953EA3B562B33" modified="2017-01-18" version="1">MRTVTVTGVGGPRLTLGFDRFDRLDLDRHRAMHGGLPAPSLGELVRMVEAADLRGRGGAGFPFARKLSAVARRSARSADGRAERPVVVVNGAEGEPGSAKDKVLLARAPHLVLDGASVAASALGTDEIVLAVESGAAARSVRAAVAERRMPARVVRLPERFVAGQSGAVVRAINGRTPVPPGRRERAAGIGVDGRPTLVSNAETYAQLAVLASLGPDLYATAGTPDEPGTTLLTVGGTTVVEVPFGTRLAEVLDHCEAAAGQGVLVGGYHGRWLDPAAASRAVLSRAGMEAVGGTLGAGIVLPLTPGTCALGEVRRIAAYLAGQSAGQCGPCRLGLPDVVRALDDLADGSGGPDAVRRAAGVGRGRGACFHPDGTARFVLSALEAFADEIGAHRRGGSCGMPVYGVLPLPVPSGEEARLAVDWTRCDGHGLCGHLLPELVRLDRYGYPVLLDFDIPPWMEHDVQRAVGMCPALALRVTTGVRETAVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SGU6</accession>
    <name>A0A1H5SGU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49670">
        <property type="protein sequence ID" value="SEF49670"/>
        <property type="gene ID" value="SAMN04489712_101199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF49670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="405" mass="41804" checksum="5D3603A93ADBD393" modified="2017-01-18" version="1">MGRIAAAALVILVDAVWLFPDRLPGRVLPVYVAALGLVFALRARTSVGALLAALSLAAVSGGPLALLVWSGFHAGHRVATSRPGAALALAGMLGYAGARIAERGMPVPAIAAECVVLLALPMAAGAYLAQHRRLVDALDEHNRRLRHERELLAERERLQERLRIARDVHDSLGHRLGLVSLQAAALEAGEPSDRERKEALRLIADASRQAVDELHELVGALRRPPEPAGPVHGPADIDALVAGFRAAGVPVALSVRGRPGRVDGPAGEAAYRVVEEALTNAVKHAPGRPVTVSLEWEPGALLLSAGNELPAGPVPEDGGRGHGLAGLAERVGLAGGLLNVERSATCFRLRALIPAAGDAVPGPEPEVRPEPPAGAGALRRLRFATLVLAAAALLSAVGPAGTGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SSU9</accession>
    <name>A0A1H5SSU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tellurite resistance protein TehA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53585">
        <property type="protein sequence ID" value="SEF53585"/>
        <property type="gene ID" value="SAMN04489712_101348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF53585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="37703" checksum="3AB352EB7C93D851" modified="2017-01-18" version="1">MTALRPAPPHAPARPAGTLRHLGPNWYACVMGTAIVANGAHALPLNPPGLHTAAVAFWALSAVLLLTVMTARALHLTRHWTQARAHLLADPSTAVFYGCPPMALLAVGHGTLVLGRDILGPATATTAATALWTTGALYAVAVATGIPYLLITRPATRTASPTPTWLLPVVAPVVAAALGPPLIPHLPPGQARETMLYACQALLGAGVLATLALLPAVLAATPRLPQPLTPTLFLVLGPLGQSTTAVAHLADGATTAAPQHAAATHTLAIVYGVPVLGFAMLWLVIAAAANLRALHHGMPFTMTWWAYTFPVGTCVTGAAALARHTGHPAFTALAAALYLLLVTAWTTAALHTARGTATGRLLQPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TKM3</accession>
    <name>A0A1H5TKM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63313">
        <property type="protein sequence ID" value="SEF63313"/>
        <property type="gene ID" value="SAMN04489712_101656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF63313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="461" mass="51468" checksum="86E8D53AC6F4FD7A" modified="2017-01-18" version="1">MTRHRTADGEQVRQISVPDTVRLGGALFVPWRTSGLVRRRSRLAALAVRFGTDRRAVRLLARLRRRYGPGPLRIPWRGQRMVLLLSREDVRRILADSPEELFTSPQFLPADTVARKVPARFQPHGVPVPPGENRGERRRADETALDTYQQVHGSAGPYIVRVYQEARALLDGISAEGVLTWDDFTATYERVTRRIVLGDSARDDRMLTDLLVRLGRARRPWREGGRDVARDTYLRRLRMYIERAEPESLARLLAQTSPGSSVEPMYQVTRWLAGFGAAGIVAYRALALLAAHPDRLRRARADLAGLPGESLPSPVATPYLGACVLESARLWPPTRVILRESAVGTRWHGRVVPAGTVFVVVVPFFGRDRAALDYADRFLPEVWLDDRAATDGAIVPFGGGTGRCAGENLAMLVASTFLGALVRGHEIRLLDPKRLRRSGRPVPYGLDPFAVRLGFRPLPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TRN7</accession>
    <name>A0A1H5TRN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65444">
        <property type="protein sequence ID" value="SEF65444"/>
        <property type="gene ID" value="SAMN04489712_101721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="35"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="4">
        <location>
            <begin position="264"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF65444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="404" mass="42541" checksum="A68AB10752DB3990" modified="2017-01-18" version="1">MAVHGGDPSGPGELREPRTSQGRALLDLLTGHLAQIRADAQDNDRRGAFPAETFTNLRKDGALGATVPVELGGLGLSCLHDVCLALLTVAEADASTALALHMQLSRGVTLAYEWRHGDDVARTLAERLLRAMGSGEGVICTTVKDAPRIRTTLAPAPGGWVLRGRKTLASMAPIATHFVISALIEQADGPPHTAAAVVSRQSPGFAVLDDWDGLGMRASGSVDVIMDGCAVPAGDVFLRGPVSVRDDAALAGQTVSSITMLGIYTGIAQAARDTAVGMLRRRGGTPKAGVRTLVAEIDAQLYALRTTVAACLANADYLSYEFTGDSGERGRRMMHAFQRTKLMVNRLAPDIVDGCLTMIGGASYTAANPLSRYYRDVRAGGFMHPFGYPDAVDYLSGVALPQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TYH5</accession>
    <name>A0A1H5TYH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H dehydrogenase (Quinone)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67081">
        <property type="protein sequence ID" value="SEF67081"/>
        <property type="gene ID" value="SAMN04489712_101770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="14"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF67081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="29053" checksum="12A07B29427E3CA6" modified="2017-01-18" version="1">MDTEPSGLVAVCAASGALGRLVVDRLLDRLPAEQIAVVVRRPAAVADLAARGVQVRHGDYDRPESLVKAFDAAARLLLISSPELDPGRRVSQHLGAVEAARSAGVGALAYTSVLGADVSDAGVAAAHHATEKAILASGLPYTMLRHPFYSEAFLAPQALRAAVTAGELADPTAGRGINTAFRADLAGAAVQVLTGSGHAGRGYDLTGPPWTYPELAATLTRVSGVPVACRPQPQEIPGPMGWLYAQARAGTLERQTDDLAHLLGHPATTVEQAVTAALTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TZW5</accession>
    <name>A0A1H5TZW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-methylcitrate dehydratase PrpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68394">
        <property type="protein sequence ID" value="SEF68394"/>
        <property type="gene ID" value="SAMN04489712_101815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="266"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF68394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="450" mass="45839" checksum="C2137675652DECA9" modified="2017-01-18" version="1">MTTIAGELAGWALRVRPDQVPEQARRAAARHLLDALGNAVAGARVTAAVAASHAARAMGPGDALIIGQRGRFTRAAAALANGVLIHALDFDDTHAGGLVHASAPVVPVVLAEGSAVSGAEALTALAVGLETICRLGAAAPHGFHAVGLHATAACGVFASALTAARLRGLSEEETVNALGIAGSRAGGLLEFLNTGSSTKQLHPGFAAADGLVAAALAAAGATGPSTVFEGEYGLYRALARRDADRAAIVGGLGDRWEATRITVKPYPACQLMHAQLDAAHQARVELGFGKVAADEITEVVVEAHPDAASIVCAPGKETPRSAYDAKFSLPWSLAAMLLDGSVTIATYDRIDRPEVLALAARVRTEVVDFGGVAADQPGRVRIRTAAGRMVTAQVPRSGGGPDDPGIDALVTAKALDNLGPGGEKIIELVLGLADLPSLAVLIRALENHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U0I8</accession>
    <name>A0A1H5U0I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68556">
        <property type="protein sequence ID" value="SEF68556"/>
        <property type="gene ID" value="SAMN04489712_101821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF68556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="478" mass="50517" checksum="F9A7B8CEC8586701" modified="2017-01-18" version="1">MESYDLVVVGAGTAGIPCAAEAALGGARVLLAEKDQRIGGTLHISGGHMAAAGTRRQAERGITDSVEAHLADIRRISSGTAREDLITTVAENAAETIDWLDDRGFTFASETPRIIYGHEPYSTPRTYYGVNEAVSILEVFEGLLAEAVATGRLDVWKNSPVIGLSTDEEGAVTGVTVLRGGGEVEVRAGDVVLATGGFAAEPELFLELEGAPLVSAAHPTSTGDGILLAQELDAAVTGTGSYLPTFGGLPDPVSPGRANWSDRQLLIAAERPPVEIYVDRSGRRWIAEDELSIDVKERALTRVEDMTFWTVFDDAMLESTRQGRPLVVGWTPDELRARAGQRVGVHSAGTLEELAVDAGIDPAGLVATVNRYNEAVAAGSDPDFGRTHLPLPLEQGPFYAIRNHGISLVTFAGLDIDSDFRVRRTDGTSVPHLYAIGEVIGAAATCGQSFCSGMLVTPAITFGRLLGRRLAATAQQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VFU1</accession>
    <name>A0A1H5VFU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86133">
        <property type="protein sequence ID" value="SEF86133"/>
        <property type="gene ID" value="SAMN04489712_102306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF86133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="479" mass="49107" checksum="1956B10D963A51D7" modified="2017-01-18" version="1">MSGGRGGVPAIVATAVPMFMVALDNLVVVNALVPIREDYGVAQPELQWVVNGYVLAFAGLLLAATALGDRYGRRRVFLGGVALFTAASAACALAGAVEVLVAARVLQGAGAAAILPLSLTLAVAAVPERLRPLAVGLWGGINGLGIALGPLVGGLVMAGLDWQWIFWINVPVGLAALPLVRRTVREGHGRPDPVDVRGTVLVTAAVTLGVWTIVRAGDRAVPPAEPLVTLVAAVALLVAFVRWERRAPAPLVPPGLVRNRAFALSNAVALLMYFGVFGSIFFLAQYLQWPMGYDPLEAGIRTLPWTLAPMVVVPVTSLLVERIGGGVLQAAGCALQGGALLWIALIAEPGTSYRGMVPALVVAGAGMGIMFAANPATVIAAVPEDQHGKASGVNNTVREFGGGLGIAVLTAVFMVWQAAHPGTPAAEEFTGALRAAVLTGAVVVLGGAVLALFIIRPAGSGKQRPAISESPVPVDSATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VHS3</accession>
    <name>A0A1H5VHS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formate dehydrogenase major subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86774">
        <property type="protein sequence ID" value="SEF86774"/>
        <property type="gene ID" value="SAMN04489712_102327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF86774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="189" mass="20922" checksum="BECF4DB07D5E518E" modified="2017-01-18" version="1">MGIGDWVSSWPVYRQLTGADRTGRGAAARSARTERLRPRVADADKVVKSICPYCAVGCGQNVYVRDGKVTQVEGDPDSPISRGRLCPKGSATLQLTTGPNRLDTVLYRRPHGTEWEHLDLDTAMDMIADRVIAARLTGWEWEDDQGRPLRRTMGFASLGGATLDNEENYLFKKLFTALGAIQIENQARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XCT1</accession>
    <name>A0A1H5XCT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09453">
        <property type="protein sequence ID" value="SEG09453"/>
        <property type="gene ID" value="SAMN04489712_103193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289282" evidence="3">
        <location>
            <begin position="34"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="52"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG09453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="466" mass="51339" checksum="055A887CC08BB02A" modified="2017-01-18" version="1">MVEQDGIGRRAALAAGLTAGVAGAVLAGGTAEAKTNERPFRADPPQRRPARPNVLVILGDDLGWADLGSYGSPNIRTPHLDALARQGVRFTDAYSAAAVCSPTRFALYTGRYPGRLRGGLEEPIARPHEQIGIPPSHPTLASLLKDAGYATAMFGKWHCGFLPWFSPIKSGWEEFFGNLSGAVDYYSKISSTGVDLYEGEVPVESLDYYTDTIADRAAGFVRRRHTKPWLLNLNFTTPHWPWEAPGDRETSAEITRRVKAGEPNALSHRDGGSLEIYRKMVESLDAAVGKVLQALRATGQEKNTLVLFSSDNGGERFSYNWPLSGQKAGLNEGGIRVPNILRWPAAIRPGQVSHVPVITQDWTATILEAAGIRPADEYPLDGHSLVPYLLKGARPPQRDLFWRTRSARALRRGDWKYLRSSSGEALYNLAEDVREQANVAQHHADLLKDLRTRWEEIDQGLLPYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XF33</accession>
    <name>A0A1H5XF33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10243">
        <property type="protein sequence ID" value="SEG10243"/>
        <property type="gene ID" value="SAMN04489712_103222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG10243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="28113" checksum="45BFABD8DECF57E8" modified="2017-01-18" version="1">MTTEYSAGGDPTRSLELLWGVRERPKRGPRPKLTAPRIAEAAIEVADAEGLAALSMRRVAERLGVSPMSLYTYVPGKAELLDLMLDTVQGEAPLLDELPGGWRARAERWARESLASYQRHPWVLQVATSRPPMGPNELTWSESALRALAETGLPDREMVAVVSSLDNYVKGAARAAVDAALAERRTGMSDEQHYRAREPLLARLITPDRFPTMNRLHYAGVFDAPVDDFEFGLQRLLDGIEHFIARHRDDTGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XTC5</accession>
    <name>A0A1H5XTC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">[acyl-carrier-protein] S-malonyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14687">
        <property type="protein sequence ID" value="SEG14687"/>
        <property type="gene ID" value="SAMN04489712_103389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="8"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG14687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="31474" checksum="ECFBEE82F884878B" modified="2017-01-18" version="1">MKSVIVIASPGQGAQTPGFLQPWLDVPEVADRLAWWSAVTGLDLVRYGTTADAEEIRDTAVAQPLLVAAALAAARALDVTPDVVAGHSVGELVAAAIAGVLTPESALVFVRERGRAMAEASAVTETGMTAVLGGDPDEVLTAIDKHGLTPANVNGAGQVVAAGTMDKLAAFADEPPAKARLRPLSVAGAFHTAHMAPAVDRLAALAAGMPVTDPATRLLSNADGAVVTSGREYVDRLVRQVSSPVRWDACMATMRELGVTAVIELPPAGTLVGLVRRELKGVQTLALKGPEDLDKARELIKAHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZH3</accession>
    <name>A0A1H5XZH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17022">
        <property type="protein sequence ID" value="SEG17022"/>
        <property type="gene ID" value="SAMN04489712_103481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="244" mass="25593" checksum="9A0203F1FAE6E6CD" modified="2017-01-18" version="1">MTETIALITGANKGIGLQTARRLGADGITVLVGARNAERGEEAAGRLRQEGADARFVEIDVADEASVAKAAGWIESEFGRLDVLVNNAGIMIDDAAPSETSLQVLRTTFETNVFGMVAVTNAMLPLLRRSAAPRIVNLSSDLGSLGLMSDPSYAHYPFVLLAYNTSKTAVNALTLCYAKELAGTPAKVNAVNPGYCATDLNAHTGPRAAEEGAAEVVRLATLPDDGPTGGYFMDEPEPGTVVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y3M4</accession>
    <name>A0A1H5Y3M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG18146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG18146">
        <property type="protein sequence ID" value="SEG18146"/>
        <property type="gene ID" value="SAMN04489712_103523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290097" evidence="1">
        <location>
            <begin position="31"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG18146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="22642" checksum="4F1AC0637CE119FE" modified="2017-01-18" version="1" fragment="single">TVMRKLVRNALVAGAATTAAVGLAGTPSFADTATWNITPNGTAFSATSTNSKLTNPRNNASLTCTSVTANGTTVATDPNDAGSVHATSPWIGHIDIHDTVASITSSAWSGCKGPLNLTFNVTQVGIWVLQATQEDPTVSNHPVQGRISNVTATIAGTGCSATVSGFARGTYDNSAKTLTISEAGGATGGLTVSGASCLGILANGDKPSFNATFPVTGNITVHRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YJF0</accession>
    <name>A0A1H5YJF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lsr2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23840">
        <property type="protein sequence ID" value="SEG23840"/>
        <property type="gene ID" value="SAMN04489712_10431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG23840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="16870" checksum="390F9416F01A037A" modified="2017-01-18" version="1">MATKVVMVDDIDGYDGEDVAKRDFEVAGTQFTIDLGDANHKRLTETLEILAPYLEKAVVVKAAGRSRKSNADVTPRLRGYTNTDVREWAKREGVEVSVRGKIADEVYEQFIAAHPDARPGTDPQSGPQLQDEPRTQDGSQPQDEPEPQDMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YLS9</accession>
    <name>A0A1H5YLS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="5" type="ORF">SAMN04489712_10479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24954">
        <property type="protein sequence ID" value="SEG24954"/>
        <property type="gene ID" value="SAMN04489712_10479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG24954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="28817" checksum="5E7E6DAB22721C89" modified="2017-01-18" version="1">MTAAPRTRPAPSSPPAGRPAGRGLHATARIVATAEAGSTRFPLLQGDGPLDLRRLRPDGPRARLCLLNAMSSPHNGDRLRVEVTIGPGADVYITSAAATVALPGPAPGHACYDVVLRVEESARLRWLPEPVVSVSGSDLRQSIRVELAPTARLLLGEQQILGRAHEPTGRLDSRLSVRCDGRTLLDQHTVYGPGAPGWDGPAVLAGNRATGQLLLIDPAIEDPSCVRLLGGTPVEGHGVIVPLPGPGRLLTAVAPDAGVLRRLFDAALCHLGFSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YME8</accession>
    <name>A0A1H5YME8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat (LRR) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25248">
        <property type="protein sequence ID" value="SEG25248"/>
        <property type="gene ID" value="SAMN04489712_10489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG25248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="375" mass="41110" checksum="F992741406CD05BB" modified="2017-01-18" version="1">MTSEVEERIGKAMHEGAREVDLSYLRLSRLPDSLRGLTWIEHLDVSGNALTDLPGWLGELSALTRLDLRWNNFTALPECLRDLPGLARLDLPANELKTLPEWLVDLTSLRSLWLQDTGLAELPEFLGQMTWLTSLNARANAFTELPESLGSLTSLQYLDLTDNALVSIPGSLGGLVALKDLGLERNALTELPESLGGLSSLGTLRLAGNALTRLPESIGGLGSLTTLNLTGNALTELPESLGDLSSLHALHLDGNSLTSLPESLGRLIRLDTLYAGHNLLTEIPESLGELSSIRYLSLRGNALTLLPESLRKLTSLKNIDLSHNALRELPDWLNDLAPRTRVVRGKQRSRVGARCACKDCLKWMEKWSPEILKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YV33</accession>
    <name>A0A1H5YV33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28119">
        <property type="protein sequence ID" value="SEG28119"/>
        <property type="gene ID" value="SAMN04489712_104209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG28119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="24361" checksum="75F7DDA26C9450A0" modified="2017-01-18" version="1">MIRVMLVDDQELVRAGFRMVLDAQPDIEVVAEAADGAQVAGTLRAVTADVVLMDVRMPRMDGIEATRRIGALPPDRQPKVIILTTFDLDEYAFAAIKAGAAGFLLKDAGPAQLIEAIRAVHSGDAVVAPSTTRRLLDRFAVHLPDKEQQVADGALATLTGREREVLNLVARGLSNAEIAGRLYVSEATVKTHMGRILTKLGLRDRVQAVVFAYETGLVRSGQHNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YV42</accession>
    <name>A0A1H5YV42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein, DUF427 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27305">
        <property type="protein sequence ID" value="SEG27305"/>
        <property type="gene ID" value="SAMN04489712_104171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="121"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="26595" checksum="871D100ACC63EEDA" modified="2017-01-18" version="1">MYLGGEVVADTTRPSLVWEVPYYPTYYFPLEDVRTDLLTPDGETKRSPSRGEGRLFTVKANGAQAAGAALRYEDSPIEALRDLVRFEWDAMDGWFEEDEEVFTHPRDPYHRVDVLASSRHIRVEVDGVTVAESASPRLLFETGLPVRYYLPKTHVRMDLLERTDTATHCPYKGEAEYWSVRVGDKVHTDVVWSYRLPLPESQKVAGLVSFYNEKVDIYVDGVKQERPKTQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z049</accession>
    <name>A0A1H5Z049_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29959">
        <property type="protein sequence ID" value="SEG29959"/>
        <property type="gene ID" value="SAMN04489712_104289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG29959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="35" mass="4136" checksum="AF1AC1B0755378BA" modified="2017-01-18" version="1">MRLQHRFAPGMRPAVMGPRRGNLFLLPPDQRRSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z0T4</accession>
    <name>A0A1H5Z0T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29868">
        <property type="protein sequence ID" value="SEG29868"/>
        <property type="gene ID" value="SAMN04489712_104285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG29868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="69" mass="7495" checksum="BFB3F21D40EF5778" modified="2017-01-18" version="1">MSAIDERGVTPRGDAEMTTLTKVATRDHDRCHVGVMRHATMVRPPRASLEANFSAASAPYNAVRTEKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z5D6</accession>
    <name>A0A1H5Z5D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent oxidoreductase, nitroreductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31492">
        <property type="protein sequence ID" value="SEG31492"/>
        <property type="gene ID" value="SAMN04489712_104360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG31492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="17338" checksum="92729B9DA47076B9" modified="2017-01-18" version="1">MTTQNQQAGKRKPGTPGAFSRWMQQKANARVNRKIRRGRGSFMGMDVLILHTVGHRSGQPRQTPVAWFDDGEGAWLIVASGGGSLHPDWYVNLMGHSDQASIELPGRDAVPVTPHVLDGADRERAWQRITAAQPRIAKYQSKSDREYPVIRLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z5I4</accession>
    <name>A0A1H5Z5I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31270">
        <property type="protein sequence ID" value="SEG31270"/>
        <property type="gene ID" value="SAMN04489712_104349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG31270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="405" mass="44358" checksum="8604B8D160020DEC" modified="2017-01-18" version="1">MGDQMTMGKRVARARKRKGWDQATLAQAMDRSVSWVTKIENGRLPLDRASVVAKLAQVLEVEVAELTGQPYRHETAELDSGHATIPELRLALQQATMPGGAAMIGERDPAPLAELAGQVTVAEKLRQDARFSALGDILPKIINDLTLHTAGLTGADRDRAEALMLRACHMARVTSNLLGHHDLGWTAVQRELVAAERVGSPELVAASAWDLCGVWLHETALDGAKSAALAALDDIDEHMGAGDPNLRALWGALHLRAAVAYSRLLDRQEAESHLSEAQRVAEELPADGNVFQTQFNRVNTRIHAVEISLELGRPREVTSRAEQVEVSEIASGERQAHYWTCRAAGMAMNRKEDKAVEALLTADRIAPQHVRNRPLVRNLVRDLRSSGRHSKGPQIRALAARMRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZAB7</accession>
    <name>A0A1H5ZAB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33251">
        <property type="protein sequence ID" value="SEG33251"/>
        <property type="gene ID" value="SAMN04489712_104447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291414" description="DUF1524 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="91"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG33251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="24061" checksum="BC8AB7EB74B754BA" modified="2017-01-18" version="1">MGLRRPVVAMATALLAVAGCSAEIGTSGDGAPQDAKPDARSVSAARADLDRLRVAEAGRGAGYERDKFGVRWRDIDHNGCDQRNDVLARDLTDIGRQGRCVVVSGRLDDPYTGKEITFRKADAAEVQIDHVYPLALAWRMGADRWTESRREQFANDPANLLAVWGVPNRQKSDSGPGEWKPRKSYQCAYGVKYIAVAHKYGLPVTRADRTALEGFLDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZBL3</accession>
    <name>A0A1H5ZBL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoA</name>
        <name evidence="14" type="ORF">SAMN04489712_104437</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33037">
        <property type="protein sequence ID" value="SEG33037"/>
        <property type="gene ID" value="SAMN04489712_104437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="13">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="245"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG33037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="36897" checksum="B5345275352BE510" modified="2017-01-18" version="1">MLIAQRPTLTEEQVEEYRSRFTIEPLEPGFGYTIGNSLRRTLLSSIPGAAVTSIRIEGVLHEFSTVPGVKEDVTDIILNLKELVVSSEHDEPVVMYLRKQGPGEVTAADIAPPAGVEVHNPDLHIATLNNKAKLEMELTVERGRGYVSAAQNKQPGQEIGRIPIDSIYSPVLKVTYKVEATRVEQRTDFDRLIIDVETKHSMLPRDAVASAGKTLVELFGLARELNVEAEGIDMGPSQADAALAADLALPIEELNLTVRSYNCLKREGIHSVGELVARSEQDLLDIRNFGAKSIEEVKQKLNDMGLSLKDSPPGFDPTAAADSYGDDDASYAETEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZG85</accession>
    <name>A0A1H5ZG85_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 6 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mdh</name>
        <name evidence="13" type="ORF">SAMN04489712_104531</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 6 9"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35100">
        <property type="protein sequence ID" value="SEG35100"/>
        <property type="gene ID" value="SAMN04489712_104531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="PTHR23382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="12">
        <location>
            <begin position="157"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG35100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="329" mass="34450" checksum="184DAFFAB68403FD" modified="2017-01-18" version="1">MTSTPVTVTVTGAAGQIGYALLFRIASGQLLGPDVPVRLRLLEIPQAVKAAEGTAMELEDCAFPLLAGIDITDDLKTAFDGANVALLVGARPRTKGMERGDLLEANGGIFKPQGEAINAHAAEDVRVLVVGNPANTNALIARSHAPDVPADRFTAMTRLDHNRALAQLSKKAGVPVSAIKKMTIWGNHSATQYPDIFHAEINGRGAAEVVDDQAWLENDFIPTVAKRGAAIIEARGASSAASAAGAAIDHVHTWVNGTAEGDWTSMAVVSDGSYGVPEGLVSSFPVTCSGGRWEIVQGLEIDDFSRGRIDASVAELAEERDAVRGLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ACG1</accession>
    <name>A0A1H6ACG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45436">
        <property type="protein sequence ID" value="SEG45436"/>
        <property type="gene ID" value="SAMN04489712_105302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF4245"/>
    </dbReference>
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        <property type="entry name" value="DUF4245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG45436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="244" mass="26121" checksum="AB90B7D602F70908" modified="2017-01-18" version="1">MRDPGRVTDKTSQQPVDSARTAARQAAAGPAAAAEGPYEVTPGVYKRLTTGLGGYSIAMLSCLLIVGLIALITPREHKETLPTADYGNHLFALRNKAPYTPYAPQGLPFTWRTTSSRVSGLDGEGPVAWHLGMVTPSEEYAALEQSDERPVGEYLWRMTNSREPVGVQQVAGQTWQRYYRKDKDQRSLVRTLPGLTLVVTGTASYEELAVLAAALKPQPKNGASASPSAPAASTSPSATPADRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADZ0</accession>
    <name>A0A1H6ADZ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_105354</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46257">
        <property type="protein sequence ID" value="SEG46257"/>
        <property type="gene ID" value="SAMN04489712_105354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="85"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG46257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="277" mass="29960" checksum="986F38FC3186B780" modified="2017-01-18" version="1">MTTVNAPFVPPGSGWPGDPATPGTPVARTPQEVRELADRAPTLHELCARESVCRACPRLVEWRERVAVERRRAFADQEYWGRPIPGWGEERPRVLIVGLAPAAHGGNRTGRIFTGDRSGDWLFASLHRVGLAAQPTSVHAADGQRLLGTRVVATVRCAPPDNKPTPAERATCLPWLEHEVAEVAPRVRAIVALGGYAWQGVWPALKKAGYEVPRPRPPFGHGVEVELTPPAGSGPGPVTLLGCYHPSQQNTFTGRVTEEMLDAVFTRARDLADPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AE50</accession>
    <name>A0A1H6AE50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Small ligand-binding sensory domain FIST</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_105338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46026">
        <property type="protein sequence ID" value="SEG46026"/>
        <property type="gene ID" value="SAMN04489712_105338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016741">
        <property type="entry name" value="UCP018953"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018953">
        <property type="entry name" value="UCP018953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FIST" evidence="7">
        <location>
            <begin position="32"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FIST_C" evidence="8">
        <location>
            <begin position="226"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG46026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="389" mass="40246" checksum="A3905D0474DB574B" modified="2017-01-18" version="1">MARFGDGLALGPDLTSAAESAVRQALAPLTAPPDLVCVFVGSEDPAAVEEAARRAMRMATGAGARIVIGCNGSGVIGGNRGVEEASAVSAWAGVLPEARLEEFRLETLRAEDRLVVVGMPEGRDDDVVGMLLADPYTFPVDAFVERSGEALPGLPLVGGLAGGQGPGRTRLMLNEEVFSDGAVGVVLGGPVTAATVVSQGARPIGPDMVVTKADENVLYELAGMPALEKLEQIVLTLPEEEQEMAAGGLLIGVAMDEYAEEHEHGDFLVRGVVGADTDTGAIAIGDVVEVGRTVRFQVRDAGAADEDLAELLERFDLAPVEGALLFSCNGRGRAMFPSSDHDVRLLHRIFGRAGVGGFFAAGEIGPVSGRNHVHGFTASILAFGPAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AGM2</accession>
    <name>A0A1H6AGM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47651">
        <property type="protein sequence ID" value="SEG47651"/>
        <property type="gene ID" value="SAMN04489712_105432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG47651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="7496" checksum="C425EA4EE2B25FC0" modified="2017-01-18" version="1">MSLVVGHCRRAWRRAVRSYLLVCARDDAAARGLTVPDGVWICGRCHQALLELTSLREHLRVEHAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AK22</accession>
    <name>A0A1H6AK22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diadenosine tetraphosphate (Ap4A) hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48365">
        <property type="protein sequence ID" value="SEG48365"/>
        <property type="gene ID" value="SAMN04489712_105471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG48365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16761" checksum="793D05048FC9B24E" modified="2017-01-18" version="1">MVCANNARFDRLPPRELIAADPYWRVAHAFGTRLPGWLVLLPRRHVTAVAELTDAEAAALGIWQVRLSRALHAVTGCVKTYVAQFAEAEGFGHVHFHIIARSGHMPAELRGPKVFTLLGRPDEEDLSTEQRDELALQIREHLGEPSPSPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AVD0</accession>
    <name>A0A1H6AVD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52210">
        <property type="protein sequence ID" value="SEG52210"/>
        <property type="gene ID" value="SAMN04489712_10614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="23814" checksum="B06D62D6B5137942" modified="2017-01-18" version="1">MSGSGRAKARRHAWRAAAAGLVFVPVLGGLSGCGDEAAPETAPSGAPSAAEFDGRAERLGVAVEIIYVIDLKGYHRATGAMGVYGNDGFQDIYVSDKGDDVRLTVERRTLTAANCPALPIPAAQTPGGSVQCTPDGDGWRRTSGDRQEYAVVDGGHLVRVSGRVGATTFDLLRDAAKNAHPADPEQLDKMLPPSEPGGPPGETPSGQVTPPPRGDLPPHGDGAPDNHVGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYX4</accession>
    <name>A0A1H6AYX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, PucR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53823">
        <property type="protein sequence ID" value="SEG53823"/>
        <property type="gene ID" value="SAMN04489712_106119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="190"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="351"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG53823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="422" mass="46306" checksum="B09505893CFF4B73" modified="2017-01-18" version="1">MRRSGGSPEPGTSRIPRLDPQTERAIKRAWSLLLPQIDEIAEGITRSLIETDPYWREQSPALQADQHNTVHEHVRRGVKAMAGVSSPDEQPIDLWRENGRVRARQGVPMERVLNAYNLGTRALWEALLRLRWDQQADIDEHLLLLAGQRLWAALDIQNAALINSYRRESALLQRRDLQRQQNFLDGLVDGRGTDPQFSQEAREALGLAPGDPVACVVALLEDPPDEPLRAPQDRLERLGVSSHWHVRGGNYFGLVPQGGLALDELATALRPGVAGRVGIAAALDGIAGFATAYRLAARAAESLPRGCQRIVTLADRLPEVLVTGSPEVAPVLVHETIGPLLAQPPNQRDMLLGTLAALLEHNGSPTQAAQVLFCHRNTVIYRAKQIETLTGRNLQDSRHRLELSLGLIASGHDPTPPGRDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B121</accession>
    <name>A0A1H6B121_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54499">
        <property type="protein sequence ID" value="SEG54499"/>
        <property type="gene ID" value="SAMN04489712_106161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="119"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG54499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="458" mass="48250" checksum="02400574AB8DD59E" modified="2017-01-18" version="1">MNEQERAHSAARARAAARELAARQIVAVALTWVDTAGITRVKTVPVTRLEHAAAWGVGVSPVFDAYLADDTVIAGRYAGSPVGDLRLHPDLDRLTILGAPAGWAWAPADRYDQDGAAHPQDARALLRGQAARLTAQGLAARAAFEIEWAVSQGPGEEFVPAARGPAYGMTRIVELPEYLLDVLGSLAAAGVEVEQLHPEYAAGQYEVSVAAEDPVGAADTSVLVRQTIRAVTIRHGMRASFSPKVVADGVGNGFHVHLSLWRDGADLMAGGSGPYGMRAEAEAFAAGVLARLPALLAVGCPTVASYLRLVPSQWSGPFACWGLENREAALRFVTGPAGQRSRAANFEVKCFDAAADPYLLLTVLLAAGRDGLAGGARLPDPVNVDPASLDEAERAARHVARLPSSLAEAVAAFESDPVLREALGEPVAGTVVDVRRGEIARFEGAAPEEIAARTRWLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3D1</accession>
    <name>A0A1H6B3D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalt/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_106225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55353">
        <property type="protein sequence ID" value="SEG55353"/>
        <property type="gene ID" value="SAMN04489712_106225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG55353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="22960" checksum="C9240959C5A16162" modified="2017-01-18" version="1">MHVPDGFFDAPVSIGAGVVAAAGIAVSLRGARRELDDRTAPLAGLSAAFVFAAQMINFPVAAGTSGHLMGGALAAILVGPYAGVLCISVVLLVQMLFADGGVSAYGINVTLMALVGVLVGYGVFRLVTAALPGSVPAKAKVTAAAFLGALASVPASALTFVGLYALGGTADLSLGAVLTAMLGVHLLIGIGEGVITALTVGTVAAVRPDLVYALRGERTPLEIRSPRPAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3T7</accession>
    <name>A0A1H6B3T7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_106217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55260">
        <property type="protein sequence ID" value="SEG55260"/>
        <property type="gene ID" value="SAMN04489712_106217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="186"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="247"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG55260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="463" mass="50991" checksum="8FABEB2C945A3137" modified="2017-01-18" version="1">MAEDERRHASRRSVQWRLTFIATGIVGLVMCLGLLVLFGVMHRQIMGELRERGTVAVRQVADTARRGPPPPEMVSRVFGFFMLQIADDQGRVIASSPALRGRPLVDDVRPGREGRPVRRVVHVPGQSTPLYVVAERVNTPDGPRIALAAASMREVEQFRRVFSLVAGAMLPLVLGLVGWTVWVSVGHALRPFALMRRELAQITGGCMGRRVTVPDTDDEVADLARSVNITLERLQRFVEAQRGFVADVSHELRSPLTGLRAQLEVALAHPDDEDWPAVARAALADADRLQRIVTDVLMLARLDAGVRSERGPVDLGELARAEATDRPRKVPVHVHVHDVARPLIVYASRTQLVRVLTNLLDNAERHASSEIRISVYRDGEEAVLEVADDGSGIPLKDRDRVFQRFQRLPESRQRDAHGSGLGLPIARDIVNAHGGTLVIGDSEQGGALLVLRLPLKETGRSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B4V7</accession>
    <name>A0A1H6B4V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55868">
        <property type="protein sequence ID" value="SEG55868"/>
        <property type="gene ID" value="SAMN04489712_106266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="30721" checksum="1B55AF380ED72E75" modified="2017-01-18" version="1">MTYRPTVRGRRLARELRRLREQEGLTLQDVADRLGWSRATVSRLETGQTRPRPGDVADILDLYGVPSPQRDALIALAKQAGLRGWWTAYADVFTGSYVALEDEASQIRSWDAQLIHGLLQTEDYARAVISAGRMLPTAADVDRRIDARKARQALLDRANAPHLHIAIDEAVVRRPIGGREVMREQLLSLVRAAERPQVTIQVLPYAAGAHAGLDGRFTILSFPDPADPDIAYVEGTMGDVYLESTVETGQHGSRFDRIIKAALSPEESAHLLAEAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B804</accession>
    <name>A0A1H6B804_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56664">
        <property type="protein sequence ID" value="SEG56664"/>
        <property type="gene ID" value="SAMN04489712_106328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13180" checksum="34891A3A5A9003A9" modified="2017-01-18" version="1">MRYGVKARGAVRVLAGGAVLTFVTAGCGMLGGNKSEVCADSRKAVEQYVSRLRTVAANEPAQWKQATEQLAARFDVLAGTAEDQALRKALKDQAAGLRTAATALGTGDAAALNKTLTDTPARLGDACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKE8</accession>
    <name>A0A1H6BKE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61189">
        <property type="protein sequence ID" value="SEG61189"/>
        <property type="gene ID" value="SAMN04489712_107192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="435"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG61189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="673" mass="72667" checksum="E47DF8CDAB411ABB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKU2</accession>
    <name>A0A1H6BKU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_107205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61341">
        <property type="protein sequence ID" value="SEG61341"/>
        <property type="gene ID" value="SAMN04489712_107205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG61341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="30739" checksum="35587520AABA7B34" modified="2017-01-18" version="1">MNGRTVRRYGLNALGLAVFAVAVFPVAWMISTAFKPNEEIFSTTPRPLPAEPTLEHFDYVLGNGIAEVSFWTYLRNSALLALATVLVSGLLAVLAATAVARFRFRFRTTFLIMLLVVQMVPLEALVIPLFLDLKQLGMINSLAGLAVVYIGFALPFSIWMLRGFVAAVPRELEEAAAIDGAGPVRTFLRVLLPLIAPGLVATSIFSFITAWNEFIFAFTFLDDQDKYTLPVMMQYFFGNASNEWGPIMAASTLLTLPVIAFFLIVQRRMVSGLTTGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BV12</accession>
    <name>A0A1H6BV12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64472">
        <property type="protein sequence ID" value="SEG64472"/>
        <property type="gene ID" value="SAMN04489712_10827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="4">
        <location>
            <begin position="351"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG64472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="540" mass="57303" checksum="A9A9E976A57AF70D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C0P8</accession>
    <name>A0A1H6C0P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein, DUF2236 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66453">
        <property type="protein sequence ID" value="SEG66453"/>
        <property type="gene ID" value="SAMN04489712_108194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="20"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="31564" checksum="700A449A484DA6DF" modified="2017-01-18" version="1">MAGESPIPRDRSVLQLLAGEPAVLVAAGRALLLQVAHPKVAQGVADHSDLRERPLDRLLGTLDFLTIVTFGTPEEAERLGRVIRRVHERITGPGYSGNDPDLQVWVNATLIEAALFVYTEVLRSPSGDLAEEYVRQARYVADVLDCPPGAQPEDLAAFRRYMDEMIGALEVSDTGREVMQAVLWPARLRWLWPALWLNRFVTTGLLPEPIRAQYGLPWNPRRDRLLHTMLRTGAFCYLLVPGSVRRSPARLGLHLSRRRIARRATGSRERSRRERERLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2B5</accession>
    <name>A0A1H6C2B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67099">
        <property type="protein sequence ID" value="SEG67099"/>
        <property type="gene ID" value="SAMN04489712_108253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG67099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="292" mass="30427" checksum="A578EE137843F7EB" modified="2017-01-18" version="1">MTVQENAREKNAPGFTPEWLALREGADAAARAPELLDPLRAHLAAAPPPAGGLVIRDLGCGTGAMGRWLAGRLPGPQHWILHDRDPGLLALAATGIGGPAGDGGPITVTAERRDVTRLGPDELAGTSLVTASALLDLLTAEEVNALAAACTPVRCPALLTISVVGRVELDPADPLDAEIATAFNAHQRRVAGGRCLLGPDAVGAAAAAFARRGAEVRTRSSPWRLDAAQAALTAQWLRGWVGAACEQRPDLAPQGHAYLRRRLRACAEGSLRVVVHHEDLLALPAPEAGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2R0</accession>
    <name>A0A1H6C2R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillinase repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66935">
        <property type="protein sequence ID" value="SEG66935"/>
        <property type="gene ID" value="SAMN04489712_108239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="109" mass="12298" checksum="714685ECE4BCFDE0" modified="2017-01-18" version="1">MLAALAALERPAGAAELRLRLVGEPAHTTVNTVLSRLCDKRLVTRIRDGRQYLYRLAVDETRLVAGRMYDHLRFANDPRSVLSRFVQSLSADEERALRQILDASRPEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C376</accession>
    <name>A0A1H6C376_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase, FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67372">
        <property type="protein sequence ID" value="SEG67372"/>
        <property type="gene ID" value="SAMN04489712_108281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG67372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="401" mass="42585" checksum="D484301AADCB40BD" modified="2017-01-18" version="1">MSAQHEGGMAAVHRVVVLGAGYAGMAAAIQLAARVKRREDVQVTLVNAQERFTERMRLHMTATGRRLAELSIPDLLEGTGARFVCGWVTAVDADAKNVRIDDGRVLPYDTLVYALGGVADTAAVPGAEEHAYTLDGAQDAEVLADRLARLGSGTVVVAGGGLTGVESAAEIAERHPELDVVLLDRREPGAAMNPKARAYLQAALERLGVRVRGGAEVVKVLPGAVELADGESIAADVVLWTSGTRVSPLAAVAGLTVDERGRIVTDATLRSVSHPEVYAVGDAAAISQGYGVMHGTCQGGMPTGVHAAVSIVRALKGRRPKPFRFGYYHTPVSLGRHDAVVQFTHPDDSPRRICLTGRTAARYKEMVTAAPWPTYGRMKKMPASGAFWPRGGRFTRGREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAA8</accession>
    <name>A0A1H6CAA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor type A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69697">
        <property type="protein sequence ID" value="SEG69697"/>
        <property type="gene ID" value="SAMN04489712_109108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="354"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG69697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="560" mass="59666" checksum="A114030F951B08A8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CD40</accession>
    <name>A0A1H6CD40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid CoA ligase FadD32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70818">
        <property type="protein sequence ID" value="SEG70818"/>
        <property type="gene ID" value="SAMN04489712_109208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="596" mass="64716" checksum="2CA952A8163B86C2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKR7</accession>
    <name>A0A1H6CKR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73046">
        <property type="protein sequence ID" value="SEG73046"/>
        <property type="gene ID" value="SAMN04489712_11065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295030" evidence="2">
        <location>
            <begin position="25"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="23627" checksum="8D9F9C421E4B8241" modified="2017-01-18" version="1">MRRETVVRALLRPAARCLPWTALAAGGGLGLVLVAVPGLFSPDIGVDAVVNLLRMAALGGALAIAFVFDDPARHTVAVLPVPRPLRQGLRVALLLPPVAVWWAVVLGVAAAGTDDVALPVGALTGEAAALCALAVGLAAGAVRFTALTAPGPAAAGTLLALFVAATVLADDVPLLVPFGDDRWESAHRLWTVLLLLASAAWVVCALEPRRRLTPARAQPPVIVRTGRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMR0</accession>
    <name>A0A1H6CMR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74329">
        <property type="protein sequence ID" value="SEG74329"/>
        <property type="gene ID" value="SAMN04489712_110214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG74329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="23839" checksum="89A133D90B10058A" modified="2017-01-18" version="1">MTASDGSPGVVGLWQVGSLAQGAGDAWSDLDLVVVPIDQILSDVVTDPVQILGAGERVLFVFRRPVNGPAGGTYAGICFEVEHLPLWVDCYVWPLQTAQVPGDARVLVERRDHPIPRTADEFSALVDRHRAPSAGGGESDQDRQRFCLLATLVASKNLARGDQSGAARMLRWVDVPAIDVTQVTSVIAGLRHLLTTVTDPDLADAVQATANWVDMAEALAPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNA4</accession>
    <name>A0A1H6CNA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74398">
        <property type="protein sequence ID" value="SEG74398"/>
        <property type="gene ID" value="SAMN04489712_110222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="28197" checksum="27EDA0D3800C46F1" modified="2017-01-18" version="1">MRKAVVTGSTKGIGLALARELLRRGHGVVVSGRTQTAVDDAVERLRPEAAGSATVHGHIVDVSDAAQVQELWDAATDALGGVDLWVNNAGVAHTTRPIVETTADDVRAMVTTNMLGTVYGAQVAVRGMLAHGGGHVFNVLGGGSDGRVRAGMGVYSATKRGLDSFTRALVKEVAGTDVRVGQIRPGVLITEGWLREAAAAPELVDKQRRTLNILCDHVDDVAPYLTDRMLASTKNGDAIAWLTNGRMMRKFLAPRRRDVLGRYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNT2</accession>
    <name>A0A1H6CNT2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_110247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74601">
        <property type="protein sequence ID" value="SEG74601"/>
        <property type="gene ID" value="SAMN04489712_110247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG74601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="311" mass="32788" checksum="ECEB2E7D50A4ACC9" modified="2017-01-18" version="1">MTVMRDDALSGAELRAFLQGLPGVDQVGAEERAARLGTRSIKASAKAEAIDLAISMVDLTTLEGADTAGKVRALCAKAVRPDPDDSSVPRVAAVCVYPDLVEVAVRALAGSGVGVASVATAFPSGRAPLEARLVDTRAAVAAGAGEIDMVIDRGAFLAGDYLKVFEEIVAVREACGGAHLKVILETGELVTYDNVRRASWLAMRAGADFIKTSTGKVSVAATLPVTLVMLEAVRDFRAVTGRQVGVKPAGGIRTTKDALRYLVLVNETVGPDWLSPRWFRLGASSLLNDLLMQRRKLATGVYSGPDYFTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNU5</accession>
    <name>A0A1H6CNU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_110248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74611">
        <property type="protein sequence ID" value="SEG74611"/>
        <property type="gene ID" value="SAMN04489712_110248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="33"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG74611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="479" mass="51474" checksum="8030302985FEA9BC" modified="2017-01-18" version="1">MSESIFEYAPAPESRSVVDIRPSYGLFIDGAFTEGHGEPFKTIDPATEDTLAEIACADSADVDRAVVAARAAFERVWGPMPGRERAKYLFRIARIIQERARELAVLESVDNGKPIRESRDVDVPLVAAYFFYYAGWADKLEHAGFGADPGPVGVAGQIIPWNFPLLMLAWKIAPALACGNTVVLKPAETTPLTALVFADICRQADLPAGVVNIVTGAGETGRVLAAHPGVDKVAFTGSTEVGKQIARAVAGSRKRLTLELGGKAANIVFEDAPLDQAVEGVVNGIFFNQGQVCCAGSRLLVQESIAEELLERLKARMATLRVGDPLDKNTDVGAINSAAQLAKIRELAQAGEDEGAARWSPACVLPQRGFWFAPTVFTGVAQSHRIAREEIFGPVLSVLTFRTPAEAVEKANNTPYGLSAGVWTDKGSRMLWMAQRLRAGVVWANTFNKFDPASPFGGYKESGFGREGGRHGLEAYLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CPC9</accession>
    <name>A0A1H6CPC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74475">
        <property type="protein sequence ID" value="SEG74475"/>
        <property type="gene ID" value="SAMN04489712_110229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295091" evidence="1">
        <location>
            <begin position="26"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="432" mass="47246" checksum="01EECAA6658734E7" modified="2017-01-18" version="1">MLKVRRGARYLALVAASVLAVSACGSSGPAGGGGSGEVRVWSLQDGVNAAERQAVAAYNKAGDGKVRMETFLNDPYKQKLQVAMGSPNAPDVFMNWGGGNLKQYVDAKQVHDLTPEFNADPAWRDRFLPVVLKTAQIGGRYYGVPERGMQPIVLFYNKDVFTTAGQQPPKTWDDLLRLVDTFKGRRITPFALAGSQAWTELMWLEYLLDRIGGPAPFQAIAERRPGAWRDPAVLRALTMIRELVDRGAFGTNYASVDYDVGGASTIFAQGKAAMHLMGSWEYATQLQQNPDFVKKNRMGWAAFPSVPDGRGDPKNVVGNPSNFMSVSAASPRKQDAVRFLKETLTSDTYIRGMVGVGEVPPVKGVEPQLRGGPAPDYTTFIYGLVSQAPEFTQSWDQALPPNVAEAMLTNLSKLFLKEQSPQQFADAMDKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSP8</accession>
    <name>A0A1H6CSP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Energy-coupling factor transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_111111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76031">
        <property type="protein sequence ID" value="SEG76031"/>
        <property type="gene ID" value="SAMN04489712_111111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG76031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="360" mass="38016" checksum="CB2B16D26BAB9849" modified="2017-01-18" version="1">MTVRLPRNLHPGAWWLWALGLATAASRTTNPLLLLLIAAAAGLVVVNRRSQAPWTLAFRLYLLLGCCVVTGRVVFRIIFGGGEGEHILFTLPQIPLPAWAAGIRLFGPVAAEQLLGGLYDGLRLATMLICLGAANALANPKRMLKAMPSALYEVGVAVTVALSVAPQLAESVLRVRRARKLRGGAQRGMRALHGIVIPVLEDSLDRSLALAAAMDSRGYGRTGDLPRRIRLLTGALVLAGLSGVCVGVYGVLDATTPRYLGLPMLGTGLLVATAGFVIGGRGVRRTVYRPDRWRPAETLVALCGLGTGALLFLTAEVDAADLYPSLSPLSWPELPLLSAFAVLAGALPAWLAPPPPRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTT3</accession>
    <name>A0A1H6CTT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_111138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76227">
        <property type="protein sequence ID" value="SEG76227"/>
        <property type="gene ID" value="SAMN04489712_111138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="75"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG76227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="242" mass="25466" checksum="0EC83CCA204766F4" modified="2017-01-18" version="1">MTDHETTIAAYADAFERRLAGPARERSRARAELVDHLSDAAAAGELDQTLRRLGDPAAAARAFAHDHPAPPAAGGRRLAAALLDNLPLAGVTVALLIHQLVRLAGPDEWTMGLAFPPFLVVEVGGVCVGTLPFTCEADPYQGAGLLYGVGVPIALAWSVLGLGMLESRTGTTPGKRLCGLKVVTTEGLRIPMWAGILRRIGLLLGPLVWLDWLPVLCAQPRRVLEQAAGTKVVACGGGEAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVX5</accession>
    <name>A0A1H6CVX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76566">
        <property type="protein sequence ID" value="SEG76566"/>
        <property type="gene ID" value="SAMN04489712_111179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295309" evidence="2">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="15342" checksum="99A43A9397EC2FEB" modified="2017-01-18" version="1">MIKRLAMVGIASVAMGGVLMATPNAMAAPNTGSSATVSAAAGEQGVGLGGWRHHHRQHGSNKNRNVNVNENFNFNRQHHHHMHHDRRFHHHHDRHFRHHNHFDRHFRHHHDRHHHRMHHHHRPTTGTVGGGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVZ6</accession>
    <name>A0A1H6CVZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione synthase/RimK-type ligase, ATP-grasp superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76977">
        <property type="protein sequence ID" value="SEG76977"/>
        <property type="gene ID" value="SAMN04489712_111232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="132"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="37286" checksum="1BC7399918C7FC2A" modified="2017-01-18" version="1">MTSAQPTVLILTQEFDPTVDPVVRSLGEKGATVVRVDLSYFPQHLSFTTANFGGGRRVLRHQDRTVDLQEVSGVWYRRPTAFVFDETMGEAERQFAHKEARHGIGGILRGTDCLWVNRPDLDAVAELKPYQLTLAEKAGLHVPRTLLTNDPQEAAAMVRDSPRPVVYKALSGGVVPYPGGFPSGLLTTVVGDEFAEHAERVRHTICMFQEYVEKAYEIRLTVIGNTYFPVVIRSQDNDATKVDWRGADHQPYGDYEPLPEEVVKGVQALLGELGLVYGAVDFIVTPEGEYVFLEVNPGGQFIWMQHELGLPLSDCIADLLMAGGPFHRDEVTQVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D153</accession>
    <name>A0A1H6D153_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79109">
        <property type="protein sequence ID" value="SEG79109"/>
        <property type="gene ID" value="SAMN04489712_112169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="30244" checksum="4AE0E529CE50893D" modified="2017-01-18" version="1">MSERPPQSQPYPGRTADMTPEPKDEMRGYTGSGLLAGKRALVTGGDSGIGRAVSVAFAKEGADVALTYLSEDGDARHTAKLVEQEGRRCVTFGGDLAERRHCREVVEHTVRDLGGLDVLVLHHGTQEPVEDLREIDDAQLRRTFDVNVFSLFWVVQAALDHLGEGSSIVVTGSINGLRGNKTLIDYAASKAAAMNLTQSLAQNLMDRGIRVNSVAPGPVWTPLIPATMPEERVESFGQQAPMGRAADPDEIAPSYVFFAAGRTSSYYTGQTLVPAGGEIHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1Q4</accession>
    <name>A0A1H6D1Q4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">SAMN04489712_112177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79167">
        <property type="protein sequence ID" value="SEG79167"/>
        <property type="gene ID" value="SAMN04489712_112177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG79167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="19050" checksum="AAA54075F68DCEB4" modified="2017-01-18" version="1">MASSTKGNGSVRPIRRLGDPVLRTECDPVRAFDAALGRLVDDMFASMYAAEGVGLAANQIGVSLQVFVYDCNDDEGRRHIGHVINPVLVAADGDIVTDAEGCLSVPGLNFPTPRHAHAVVEGVDLDNKPVRVEGTGYFARCLQHETHHLRGGVYIDVLKGDTRREAMRAIRSADWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D609</accession>
    <name>A0A1H6D609_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80701">
        <property type="protein sequence ID" value="SEG80701"/>
        <property type="gene ID" value="SAMN04489712_113134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="63" mass="6910" checksum="DEF9B3609238E034" modified="2017-01-18" version="1">MTRSYSRWRKSSHSDPDGKCVEVARAADGTIGVRDPKGDPTAVLEVTPQEWARLLAQVKAQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D638</accession>
    <name>A0A1H6D638_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80215">
        <property type="protein sequence ID" value="SEG80215"/>
        <property type="gene ID" value="SAMN04489712_11341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="430"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="535"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="641"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="967"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG80215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1079" mass="116637" checksum="155B617857BFEB09" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6K4</accession>
    <name>A0A1H6D6K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_113106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80578">
        <property type="protein sequence ID" value="SEG80578"/>
        <property type="gene ID" value="SAMN04489712_113106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG80578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="214" mass="23179" checksum="A83027E5AD2DBE3E" modified="2017-01-18" version="1">MRVMLAEDSTLLREGLVRLLAEEGHEVVAAVGDADALLAAVAADPPDVVVADVRMPPTHTDEGVRAALEIRRRWPGVAVLVLSQYVEQRYATDLITGEGGGVGYLLKDRVGQIDEFLDALDRVAAGGAAFDPEVVRRLLARSTRTDPLSRLTPRERDVLGLMAQGHTNASIAAHLHVSQSAVEKHVNQIFDKLDLTGTTGFSRRVLAVLRYLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D742</accession>
    <name>A0A1H6D742_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, contains XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80904">
        <property type="protein sequence ID" value="SEG80904"/>
        <property type="gene ID" value="SAMN04489712_113174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="20828" checksum="3B234E76750FB0CB" modified="2017-01-18" version="1">MDSSATNRPAMDDGTADLADVGRRLRALREERGLSLSELARRAGVGKATLSGLEAGTRNPTLETLWAVTGELGVPLTALFTRPPGQSTEPDSPVFHGESVEATLLRVFDDETVTYELYQVRFPAGTAQTSPPHPPGVTEHLTVFAGTLLAGPIGSLREAGPGDYVTWRSDVPHGYRVIGGQDVHASLLLRYPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7X5</accession>
    <name>A0A1H6D7X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81399">
        <property type="protein sequence ID" value="SEG81399"/>
        <property type="gene ID" value="SAMN04489712_11447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="202" mass="22818" checksum="845740F4E06EAB9C" modified="2017-01-18" version="1">MASSRRIGAPDAKNRTVLLDAAERLMLEEGYAAVSSRRVAAKAGLKPQLVHYYFRSMDDLFLAVLQRRVEEALRHQAEALASDQPLWALWEFSTEAEASAVTMEFVGLANQRKAIRSKIAHYAEQFRREQLKALPDIMKRYNLDPDMLPPGALIVLMTSVSRVVMMERALGMSIGHAETIALIERHLERLEGPRRPARPRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8V6</accession>
    <name>A0A1H6D8V6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">o-succinylbenzoate synthase</fullName>
            <shortName evidence="4">OSB synthase</shortName>
            <shortName evidence="4">OSBS</shortName>
            <ecNumber evidence="4">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menC</name>
        <name evidence="6" type="ORF">SAMN04489712_11490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81588">
        <property type="protein sequence ID" value="SEG81588"/>
        <property type="gene ID" value="SAMN04489712_11490"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00470">
        <property type="entry name" value="MenC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010196">
        <property type="entry name" value="OSB_synthase_MenC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041338">
        <property type="entry name" value="OSBS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18374">
        <property type="entry name" value="Enolase_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="5">
        <location>
            <begin position="76"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG81588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="35123" checksum="174D474877C65985" modified="2017-01-18" version="1">MRVYSIPMRTRFRGITRREGVLIQGPAGWGEFSPFAEYGPGECARWLAAAREAAHDGWPAPLRETIPVNVTIPAVDPERAHEMTRVSGCRTAKVKVAERGIDPARSDAEDLARVEAVRDALGPDGRVRVDVNGAWDVDRAARMIRRLDRFDLEYVEQPCATLEELARVRRLVDVPVAADESIRRAEDPLKVRAAGAADIAVLKVQPLGGVRAALRVAEQTGLPVVVSSAVETSVGLAAGLALAAALPELPYACGLATLSLLEGDVVVDPLVPVDGRIPVRRPEPDPGALRRYEAGADEGAGWRRRVADAQALMDAPPVIAVTRGVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DA51</accession>
    <name>A0A1H6DA51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81964">
        <property type="protein sequence ID" value="SEG81964"/>
        <property type="gene ID" value="SAMN04489712_114181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="31476" checksum="3E7D58C1E3A470D8" modified="2017-01-18" version="1">MQGRLMAAERMRRGRASAKAPAGLRHRGRALRGAPSTPPTNIIEAVLPQARDVIRRVREEDTGPLGRLLRSRPATRRPTSMRRPVSMRRMELMGRQVLVIRMARRRSGPAGMRGRALSPMPGRVPRGLSAIGRSRATPVVGAALMAAGIAVSRRLIARSGEAGRRDFGNRWSMVTVNCPPERLASRSDLPEPLARLGDAVEIRVSRAPGDRGTELGARLLEERRGRGGMMALLGGEDPRRAVRRALREAKALIEVGEVIRRGEVTPERPPRPAEKVMELAGRRGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEP8</accession>
    <name>A0A1H6DEP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acyl-D-aspartate/D-glutamate deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83907">
        <property type="protein sequence ID" value="SEG83907"/>
        <property type="gene ID" value="SAMN04489712_11698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="46"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="546" mass="59139" checksum="0D35DADAF0474860" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHK1</accession>
    <name>A0A1H6DHK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84689">
        <property type="protein sequence ID" value="SEG84689"/>
        <property type="gene ID" value="SAMN04489712_11750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="154" mass="17735" checksum="927CCD91E4503A36" modified="2017-01-18" version="1">MSTIEQSIDVEVPVRTAYDQWTQFEEFPRFMEGVERIDQVSDTRTHWHTKIGGVTREFDAEITEQRPDERVAWTSLEQPRQAGVVTFHRLAPGRTRVMLQMEFAPEGMAEKAADALNIVERRVKGDLRNFKKFIEARGTETGAWRGEVGQNPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DI65</accession>
    <name>A0A1H6DI65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84533">
        <property type="protein sequence ID" value="SEG84533"/>
        <property type="gene ID" value="SAMN04489712_11720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG84533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="657" mass="70724" checksum="11575279B463613F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DID8</accession>
    <name>A0A1H6DID8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_117114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85018">
        <property type="protein sequence ID" value="SEG85018"/>
        <property type="gene ID" value="SAMN04489712_117114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG85018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="703" mass="74013" checksum="B5FE304080398246" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIR8</accession>
    <name>A0A1H6DIR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted metal-dependent hydrolase, TIM-barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_117140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85114">
        <property type="protein sequence ID" value="SEG85114"/>
        <property type="gene ID" value="SAMN04489712_117140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="101"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="44813" checksum="25CA1AD23BC513C7" modified="2017-01-18" version="1">MPSRELPFPLFDADNHLYETPEALTRHLPKQYEGAVQYVQVKGRTKIAVRGQISEYIPNPTFEVVARPGAMEEFFRVGNPDGKSRREIFGEPMKSIPAFREPAPRLELMNEQGIERTLMFPTLASLIEERMRDDPELIHAVVHALNQWLFEVWSFNYQDRIFTTPVISLPIVDRAIEELNWCVERGAKAILVRPAPVPGFRGPRSFALPEFDPFWKRVQELGILVGLHSSDSGYSRYANDWEPQTEMLPFKPSAFRSAQEWRPIQDAVTSMVCHGMLSRFPDLKVAVIENGMAWVGPMMQTLSDVYKKMPNEFQEHPVEVMRRNVHVSPFWEENMADLAELLGADNVLFGSDYPHPEGLADPVTYIDELERVGLGQAEQAKVMGGNMARLMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DK96</accession>
    <name>A0A1H6DK96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85529">
        <property type="protein sequence ID" value="SEG85529"/>
        <property type="gene ID" value="SAMN04489712_11825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="41" mass="4222" checksum="9CE8BEA0AB019E10" modified="2017-01-18" version="1">MRVVQRIADDGRPAAHRTGSPVSGPGRAPDAEEADEVGVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKN8</accession>
    <name>A0A1H6DKN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="7" type="ORF">SAMN04489712_11882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85798">
        <property type="protein sequence ID" value="SEG85798"/>
        <property type="gene ID" value="SAMN04489712_11882"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG85798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="30538" checksum="46FC35984991D4BD" modified="2017-01-18" version="1">MATLVLLRHGESVWNAEGLFTGWVDVDLSAKGESEATNGGDLLLDADITPDVVHTSVLKRAIRTANIALDVADLLWIPVRRSWRLNERHYGALQGKNKAQTREEYGEEQFKIWRRSYDTPPPPIDDKDPLSQVNDLKYAHLPSELIPRTECLADVVDRMLPYWYDAIVPDLAAGRTVLVAAHGNSLRALVKHLDDISDTDIAELNIPTGIPLVYELDDDFAPLKKGGEYLDPAAAKAAIEAVKNQGASSAGGAKAPAPKPAPKAAAKKPSRADRKAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMS5</accession>
    <name>A0A1H6DMS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86657">
        <property type="protein sequence ID" value="SEG86657"/>
        <property type="gene ID" value="SAMN04489712_119139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296130" evidence="1">
        <location>
            <begin position="29"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="19834" checksum="7A5A926848937243" modified="2017-01-18" version="1">MRKPVHGGTVIAAAATAVIGLTALPALAATWTVTGSVGPYRAVSVNTKLTKGFYTFSCIPFAAGASVTLNGSLPNGTGLTSPIGNVTSSAWLGCSGPVGLVTISHTGAWLINPASQSGGPTSPVTGSISNIGFTIAGSGCTATITGSVNFIYNNAGTLQLTGGTGLTVTSASCGSYLVVNDQPVLTGSFAVTPNTIRIKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNY9</accession>
    <name>A0A1H6DNY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OB_aCoA_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86245">
        <property type="protein sequence ID" value="SEG86245"/>
        <property type="gene ID" value="SAMN04489712_11931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="55"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="15288" checksum="116D3B90565A1139" modified="2017-01-18" version="1">MSGEPKPVPRPTPETRPYWEATQRRELVHHRCDGCGAGTQHPRAICACGSTDLTWTSCTGRGRLFSYVVVHRPEPAFADEAPFVLAIVELEEGVRMTTRIVDVPADPAALPLDMDVELRWLERGDVNLPVFAPAAPEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPA0</accession>
    <name>A0A1H6DPA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86375">
        <property type="protein sequence ID" value="SEG86375"/>
        <property type="gene ID" value="SAMN04489712_11965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="25871" checksum="C96BAFD947A6EFA8" modified="2017-01-18" version="1">MSPVVIDRRESALWARIDRPEAGNACSSEVMAGLENWLDRAVEPGVRVLVLTGTGSSFCAGADLTEGRSLLGNPSALWEFLDRGRDLARRLRSAEKPTIAAVNGAAYGGGLELLLACDIAVAARSARLGDRHVAVGQVPGWGSSAMLPSAVGPALARRLLITGETWSADEAALRGLVSEVVADSELDDHVAAIARSIAALEAPAVARMLKVARPVGDDSAWARETGTLREHIAAQITSHEAAQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQU8</accession>
    <name>A0A1H6DQU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_120137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87464">
        <property type="protein sequence ID" value="SEG87464"/>
        <property type="gene ID" value="SAMN04489712_120137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7289" checksum="A9FCF1EC83DD5BE9" modified="2017-01-18" version="1">MANRDRSFVAWRKSSHSNGGGECVEVAAAHGMVAIRDSKAPKAPHLVTTAQDWRSLLSAVKRGMLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRG1</accession>
    <name>A0A1H6DRG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87932">
        <property type="protein sequence ID" value="SEG87932"/>
        <property type="gene ID" value="SAMN04489712_12139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG87932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="475" mass="48144" checksum="D92D3696B61EC427" modified="2017-01-18" version="1">MTQATQPTEARPAATAASRGPGGLMLAVLLLGQFMATLDVNIVNVALPTLRADLHASGAGLQLVVAGYVLSYAVLLISGARLGGVAGHRRMFQLGLAVFTLASLACGLAPGTGPLIGFRFLQGAGAALMTPQVMSMIQQSFGGAARARALGLYAAVTAGGVVVGQAAGGLLVSADLFGAGWRTVFLVNVPIGVLLLVAGPRVLPADERRPGGGLDLPGLLVLSPAVLLVVMPLILGPETGWPAWTVASLAAGVVFFGVFVAVERRVAARGGRPLISGRVLRAPGLLPAVGALLLGPGTWGAFLFTTTLHLQGDLRMSPLESGLAFVPCVAAFGLVGLNWQRLPAHWHPRLIPVGFALAAVAYLCVGPLAGGGVPYELLTALIGLGLGVMPIIITVALEHVPVEDAADASGLLLTVMQISQVVGVATVGTLFLTLARDSGSTRTAEYGTGWALAACALVAAAGALLLARRRPTVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRK0</accession>
    <name>A0A1H6DRK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87909">
        <property type="protein sequence ID" value="SEG87909"/>
        <property type="gene ID" value="SAMN04489712_12133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="38" mass="4470" checksum="6E8F8BACE3A5E5ED" modified="2017-01-18" version="1">MTRVLVVDDSPQILATLRRKLERDPSRPRRSRTPAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRQ6</accession>
    <name>A0A1H6DRQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhnB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88032">
        <property type="protein sequence ID" value="SEG88032"/>
        <property type="gene ID" value="SAMN04489712_12161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="15439" checksum="AEAD03CA7F23F6C9" modified="2017-01-18" version="1">MSINAVTHLNFRGDARAALTFYQSVFGGDVVMVTYKDAGNVQDPSEADQVMWGQVTAASGFRVMAYDVPSRTPWSQGENAFFVSLRGEAAEEVTSYWERLSDGATVLQPLGPAQWAPLYGMLKDRFGVTWVVDVVSEYSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT47</accession>
    <name>A0A1H6DT47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87923">
        <property type="protein sequence ID" value="SEG87923"/>
        <property type="gene ID" value="SAMN04489712_12137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_16" evidence="7">
        <location>
            <begin position="265"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="805"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="848"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="930"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="eIF2A" evidence="6">
        <location>
            <begin position="933"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1018"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1133"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1266"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1309"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG87923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1588" mass="169117" checksum="B7A9D48A2BDFE1EE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVJ6</accession>
    <name>A0A1H6DVJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">SAMN04489712_12359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89288">
        <property type="protein sequence ID" value="SEG89288"/>
        <property type="gene ID" value="SAMN04489712_12359"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="48"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG89288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="175" mass="18672" checksum="F055D2B59C47EA35" modified="2017-01-18" version="1">MIDLGKLIAERIRDVADYPKPGVVFKDITPLLADHVAFAGVVDAIVSHHGRGTVDKIVGIEARGFILAAPVAYHFGAGFVPVRKKGKLPARAHEQTYDLEYGTETIEMHADALRPGERVLIVDDVLATGGTAQAAAELVRRGGGEVVGLSVLMELSFLNGRDKLGNLDVHSLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXJ6</accession>
    <name>A0A1H6DXJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylornithine deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90062">
        <property type="protein sequence ID" value="SEG90062"/>
        <property type="gene ID" value="SAMN04489712_12527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010175">
        <property type="entry name" value="LysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01902">
        <property type="entry name" value="dapE-lys-deAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="479" mass="49383" checksum="A2B7C722FA77A90C" modified="2017-01-18" version="1">MPAPAYRPLTVVQLPPAPSPGLLDDLAELAGRGRVLAAGPPNAVDALRGRGLEVLAGQDARALGVLLDHADAVTVEAASAADVLALARDLDADHVRLAPGADGLDLDGLAADVVVCAEGTLSPSAGTRLWRTAAPAADLELLSRAVQISSVSGDERDLAEFLAAWCARQGIDAEVDAAGNLVATRGTGPRRLLLLGHLDTVPHRWPARWHGDVLTGRGSVDAKASLVAYLQTLAELDVPEGAQVRVVGAVQEEVTSSGAFHVRDHYPADAVVVGEPSGAHALTVGYHGLCKILLAVREPTAHTAGRGVRTAADRLVDAAAAVRSAVAALSPDALVAVLGVDARNHGDVQAGDAVIDVRVPPGVATADLRAAVRAAVPAPVTVGFQRCTPGVATPRSSGLVRAFTRALRAAGSTPRHLAKKGSSDMNTLATTWEGVPMVAYGPGDARLDHTPHERLDATEYRHARTVLAAAVRDWLSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZP5</accession>
    <name>A0A1H6DZP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90323">
        <property type="protein sequence ID" value="SEG90323"/>
        <property type="gene ID" value="SAMN04489712_1262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="29822" checksum="A2F3C57A37214DAC" modified="2017-01-18" version="1">MKNIVVTGGTSGIGLALARICRDRGDNVLVIAPDPAKGERFIEESENKGAGKRVFFIPADLSLVGENERVIDEIGDTFTTVDALVLCARFFRSYRRVTAEGFEHNFALYYLSRFLLSHGLVEPMRRAGAAAILNVAGPGVAAGRIHWDDLELEHGYNGWEAMFQGGKLNNLLGVSWAAAHGGQGVGYVLQFPGGTRTGLAGEFDPETAAQVEQMKQGATKSAEDSAGPLVDVIDNPPAEPLTALWEDRPISLDDGSFDAEDAARLHRLTEKLLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E005</accession>
    <name>A0A1H6E005_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90443">
        <property type="protein sequence ID" value="SEG90443"/>
        <property type="gene ID" value="SAMN04489712_12639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="263"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG90443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="40422" checksum="41DBF148AC2FAA50" modified="2017-01-18" version="1">MPEAVIVAATRTPIGRAFKGSLVTARPDDLSGTIIDAALRKVPALDRSEIGDVIMGAANHVGEQGMNLGRNAAALAGLPDTVPGTTVNRGCGSSLQSIRMAHQAIATGEGHAFVAAGVESVSRLPGVYDREAMNPRFLDSGRDDYINDMYISMGETAENVAKKYGVTRRDMDEFALLSQRRAAAAIEAGFFAREITPVTLDDGTVVDRDDCPRPGTTLDGLAALKPAFREDGTVTPGNSCPLNDGAAAVVVMSDVRAAELGITPLARIIGSAVTGLAPEIMGVGPIAAVGELLARHGMRIDDVDVVELNEAFAAQVLPIARELGISIEDQLNPHGGSIALGHPFGMTGTRIMTTLINDLQTLDKQIGLETMCIGGGMGIAMLVERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3P6</accession>
    <name>A0A1H6E3P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92197">
        <property type="protein sequence ID" value="SEG92197"/>
        <property type="gene ID" value="SAMN04489712_13254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="101" mass="11222" checksum="694D721D245F7347" modified="2017-01-18" version="1">MVIGHLDRLAAALLDDGWQVLPRYDHDPPFLRVWHPDLEVLGLSVGVRPGPAGTRQAAVWWYVMLPHVRLTPCADVAGAVGQIAWLLGPWVMAARQRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5R4</accession>
    <name>A0A1H6E5R4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92539">
        <property type="protein sequence ID" value="SEG92539"/>
        <property type="gene ID" value="SAMN04489712_13428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="131" mass="14304" checksum="0EF3AC0B061E6658" modified="2017-01-18" version="1">MRLVVTTRDRRDYDEALRFYRDVLGLTERAAFSSEGGRVTILEAGRATLELADPPHAEFIDEVEVGRRVAGHIRVAFEVDDSPAVTAELAEAGAAVLAEPTRTPWNSLNSRLTGPAGLQLTLFTELGEPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5U0</accession>
    <name>A0A1H6E5U0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdxH</name>
        <name evidence="10" type="ORF">SAMN04489712_13317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92326">
        <property type="protein sequence ID" value="SEG92326"/>
        <property type="gene ID" value="SAMN04489712_13317"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:pyridoxine biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="73"/>
        </location>
        <ligand>
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        </ligand>
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            <position position="73"/>
        </location>
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            <begin position="83"/>
            <end position="84"/>
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        </ligand>
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        <location>
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        </ligand>
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        </location>
        <ligand>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
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            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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            <position position="138"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
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        </ligand>
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        </ligand>
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        </location>
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        </ligand>
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        </source>
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        </source>
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        </source>
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        </source>
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            <dbReference type="EMBL" id="SEG92326.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="233" mass="25788" checksum="450B8232ADAA2EE9" modified="2017-01-18" version="1">MQHNPDPARLRSAYEGNGTVRSSFPGDLPGEPVDLFAAWFTDALAAGLPEPNAMVLATASADAVPSARLVLLKGYGIDGFRFFTNHTSRKGRELAANPRAALVFPWHAIHRQVRVTGPVRRLSEEDSAAYFRSRPYGSQVGAWASHQSAVVGSREELDARYAELAEKWPDPAVVAGAEEVPVPPFWGGYLVVPEEIEFWQGRPDRMHDRIRYRREETGGVAPSGRWVIERLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6C2</accession>
    <name>A0A1H6E6C2_9ACTN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SAMN04489712_13827</name>
    </gene>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG93348.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="182" mass="19302" checksum="A4923BDD7C53A5C4" modified="2017-01-18" version="1">MTGWASETARSILETPLPRRWAHTQGVAAQARSLAPIMGDDADLLEAAAWLHDIGYAPALVVTGFHPLDGARYLRDVLGAQDVLCRLVAHHSCAIIEATERGLAGELAGEFPPGPKALTEALIYCDMTTGPDGTHLTVERRLAEIHARYGPGHLVSRAIEAASPRLLGAVHNIAGQLPVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E816</accession>
    <name>A0A1H6E816_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv2161c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13640</name>
    </gene>
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        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
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            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="256"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG92995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="30991" checksum="BCC116DD25DF6DD1" modified="2017-01-18" version="1">MEFGVQLGAVNPKLWGEVAEEADRLGFESVWIPEHLVVPIDTAGSPHQGSDHPPIPPEVPVFDALGMLCHLAARTTRIRLGTCVYNIGLRHPFVTARAATTVDVLSGGRLAFGVGASWLRSEWEAVGLDFDRRGARVDEAIAVCRRLWSEAVVEHHGEFFDFGPVAFEPKPVQRPGPALHIGGDGAAALRRAATVGTGWMPMNHTLERLPRSLALLGELAERAGRTTPIEVTLPGARISRPEEIESYARAGVTRMIVAPWTRSREALDGLRRFADEILRPAQATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EA31</accession>
    <name>A0A1H6EA31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_1429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="SEG93959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="SAMN04489712_1429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
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        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="130"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="237"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG93959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="381" mass="40855" checksum="018A8D22307E8238" modified="2017-01-18" version="1">MTLRITAVDAPPGALHELRLEVREFLRREIAAGGFEPEADAWMSGVDPAFSRRLAGRGWVGMTVPARYGGHGRSALERYVVTEELLVAGAPVAAHWIADRQMAPGILRNGSEEQKHRYLPGIVRAEQFMAIGMSEPDSGSDLASVRTRAVEVDGGWRLTGTKVWTSVAHIATAIVVLARTDEGGDRHSGLSQFIVDLPHPAVTISPIITIDGAHHFNEVVFDDAVVPQSALLGRRGDGWRQVTAELGNERSGPERFLSALPLLLAWTRTGAFADDPLARADLGRLVSRLTALRQLSLAVAERLSAGENPAVEAALVKDLGTAFEGEMVDVVRRHVDPASGAVPEQLAAMLAKAVLHVPAFTLRGGTNEVLRSIVAKGLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAN5</accession>
    <name>A0A1H6EAN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94283">
        <property type="protein sequence ID" value="SEG94283"/>
        <property type="gene ID" value="SAMN04489712_14512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="615" mass="67995" checksum="B14C43CA8BF6994D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAS0</accession>
    <name>A0A1H6EAS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-, maltotriose-and DNA-dependent transcriptional regulator MalT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_14227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG94016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94016">
        <property type="protein sequence ID" value="SEG94016"/>
        <property type="gene ID" value="SAMN04489712_14227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="831"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG94016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="903" mass="97902" checksum="56BC46D2E0DF2835" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB71</accession>
    <name>A0A1H6EB71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn-dependent amino-or carboxypeptidase, M28 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000067">
        <property type="protein sequence ID" value="SEG95118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95118">
        <property type="protein sequence ID" value="SEG95118"/>
        <property type="gene ID" value="SAMN04489712_1671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296741" evidence="4">
        <location>
            <begin position="28"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="5">
        <location>
            <begin position="101"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG95118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="38007" checksum="E3E073B186548A5D" modified="2017-01-18" version="1" fragment="single">MRSPLFVVAGAAILALSATLTGHSASAAPVPAVAAAPDIPLANVKAHLTQLQTIATNNGGNRAHGTTGYRASADYVKARLDAAGYQTTLQSFTYGGATGYNVIADWPGGDPNQVIMTGAHLDSVSAGPGINDNGSGSAAILETALAVARENFQPDKHLRFAWWGAEELGLRGSQYYVNNLPSAERTKIKGYLNFDMVGSPNPGYFVYDGDNSDGVGSGPGPAGSAQIEQVIQSYFTSIGVPTRGTDFDGRSDYGPFISVGIPAGGTFTGAEGIKSSAQAQLWGGTAGQAFDRCYHRSCDTTTNINDTALDRNADAIASSVWTLAGTATPPGQIVFSDDFETNKGWTVNPNGSDTATAGQFQRGIPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBR9</accession>
    <name>A0A1H6EBR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_15021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94723">
        <property type="protein sequence ID" value="SEG94723"/>
        <property type="gene ID" value="SAMN04489712_15021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="93" mass="10358" checksum="15891C3F3C5480DB" modified="2017-01-18" version="1">METSMSVELELLAELRGALTEYEISSEVHEDVAALAVSTDTPGVYLWVFVSFSGRFFSWNRGNHQHPVNDIPGTARRLKTHIEGFHLLGGAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBZ1</accession>
    <name>A0A1H6EBZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">23S rRNA m(1)G-748 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000051">
        <property type="protein sequence ID" value="SEG94791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94791">
        <property type="protein sequence ID" value="SEG94791"/>
        <property type="gene ID" value="SAMN04489712_1518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016718">
        <property type="entry name" value="rRNA_m1G-MeTrfase_A_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018249">
        <property type="entry name" value="MyrA_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="3">
        <location>
            <begin position="92"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018249-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018249-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG94791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="30595" checksum="48368F5FEF677B8C" modified="2017-01-18" version="1">MLTDVVKVLACPLCGADLVVGDRTLRCRAGHGFDIARQGYVNLLPGNARTGTADTPEMVRSREAFLGAGHFAGLADVLAERAGAVLAPDACVLDAGAGTGYYLARLLDRAPTATGLAIDVSKHSLRRAARAHPRIGAVVADLWKPLPVRTAAAEAIINVFAPRNGAEFHRVLAPGGMLYVVTPTARHLGRLIPDLGLLKVDDRKRERTEQALRDHFVLDGAEDHEAEVRLRHDEVVTLVGMGPSAHHLAPGELQARLAELPDPVPVPLSVTISAYRPHSRGGRPGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECK6</accession>
    <name>A0A1H6ECK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94686">
        <property type="protein sequence ID" value="SEG94686"/>
        <property type="gene ID" value="SAMN04489712_1507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="79"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="190"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="409" mass="45229" checksum="E2B3D51A2F738F29" modified="2017-01-18" version="1">MPDTPNKPNTPRKARPKLRDGVMKRGTTWSYVIRVKDPETGISKPKWVGGFPTEDEAKAARDEARVKARRGEYIDRNAITVAEYLDEWIEAHAVEIKPKTLQDYRHLIERHVKPHIGGLRLQAVRPARITKLYRDLVTSGGRNGAGLSPRTVAYVHAVLRKAFGDAVLVDQLLPSNPVERAKRPRTQRPEPGKIWTAAQLRAFLKVAESHRLSAFFHLAAYTGARRGELLNLRWRDVDLDGATIHIKGSAAFVAGQRIEGTTKSGRSRIVSIDAGTVKVLRAHRKRQAAEQLEAGESWKATDDHVFRTAWGDPIHPDTVSSLMSDLIKVHNAPKDGPRPAAPLPHARLHDLRHIHATTLLLAGVPVHVVAARLGHADPSITLRVYAHVINEQLAEAAEVFAKTIGEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S2K0</accession>
    <name>A0A1H5S2K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44128">
        <property type="protein sequence ID" value="SEF44128"/>
        <property type="gene ID" value="SAMN04489712_10131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF44128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="111" mass="11742" checksum="BB621A4384E0A20C" modified="2017-01-18" version="1">MGRWDYGQETLVNLARNTGDRGEELAGLVKALIVAAEPLSGRFNGAGKAAFDNFKARSDQIIADLKGGLDRVNVGQVGMEQAFATGDQSMADEAGRAMSTADFDAAKFRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S6T2</accession>
    <name>A0A1H5S6T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46305">
        <property type="protein sequence ID" value="SEF46305"/>
        <property type="gene ID" value="SAMN04489712_101100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF46305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14878" checksum="EAD3256868AA6CD7" modified="2017-01-18" version="1">MDEQAHRRTFRGERAELAAVHRFAREALPPGCPVLADFLLLLDEVAANAVLHSDSGRPGGAFEVVIRHRAGVVRAEVHDAGPRRPPGTPLPPAWSQEAGRGLLLVSMLAREWGTVALPHGRVVWFEVADHHRLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S7Z8</accession>
    <name>A0A1H5S7Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46544">
        <property type="protein sequence ID" value="SEF46544"/>
        <property type="gene ID" value="SAMN04489712_101106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="15"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF46544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="15559" checksum="F0C770B34D174920" modified="2017-01-18" version="1">MQSNPGSPHSDLTLAARPGAARQARRHVARVLPGWGMAGLADTAELLASELVTNAVRATAALVAAAPGEDRPPVVPPDRLGTIRLRLSRPGGRLRIEVWDADGRPPVPRAADADAEGGRGLLLVAALSAGWGWHPARDGGKVVWCEPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SCM6</accession>
    <name>A0A1H5SCM6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47507">
        <property type="protein sequence ID" value="SEF47507"/>
        <property type="gene ID" value="SAMN04489712_101133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="376"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="445"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="510"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="594"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF47507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="654" mass="69418" checksum="CE4035020B63022F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SGW1</accession>
    <name>A0A1H5SGW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49862">
        <property type="protein sequence ID" value="SEF49862"/>
        <property type="gene ID" value="SAMN04489712_101205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09022">
        <property type="entry name" value="Aldose_epim_Ec_YihR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037480">
        <property type="entry name" value="YihR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="33213" checksum="A3BF13BF71F42006" modified="2017-01-18" version="1">MSEQITGSQYEITAGAYRAVVTESGAALRELAWQERPVILSHGADEPAPAALGQLLIPWPNRVDHGRYTHDGQTYQLDISEPELDCAIHGLVRWAPWTAVEHKPDRLRLVHRLLGSAGYPFRLDLDVEYTLAADTGLTVRVTARNSGARTAPYAHGMHPYITVGEPIDDCEVTIPGDRYLPVNDRMIPEGPAQDVTGTPYDRRKPDLLGAQQIDNAYTGLHRDEAGRAWVRLRGGGRAVSFWQDDAQPWLEIYTADALPEGLRRRGLGVEPMTAPPNALASGIDLIHLEPGHTTTGSWGIIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SME2</accession>
    <name>A0A1H5SME2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51610">
        <property type="protein sequence ID" value="SEF51610"/>
        <property type="gene ID" value="SAMN04489712_101272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF51610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="39388" checksum="5F462DE1E1922C61" modified="2017-01-18" version="1">MIILSGVLVVVAIGLLVAGIVAGDEAGAQVLGVDALMMIYISIAVSIVSALCLIVGVFLRRRELLFGTGASPARTARAKGRKGRKKAGRKPGRQTPAPATARAADTAPVATGAAQPARVPDEALVHVIPGRKRYHLASCRQVAGRGTEELTYVEAREEGFSPCTACMPDTVLAARAASAAQSAEHDAKSAEDAKGTKGAKGSKTTKGSRTAQAAADSEAERQDGTAEQERGPGKDAGSGTTAVLTKPDVPTDSATRPGPGESAPTAPAPAAPSTVPSAWSPPASSQDGSRDTAARSTAKPTVAEQAASEPASDIAGDAQTAPAPSAGSDPQVRILSGTKRFHRSDCALIEDIGDETEELQALPLSEARARGCTPCLVCQPDKAHARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SWY8</accession>
    <name>A0A1H5SWY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55029">
        <property type="protein sequence ID" value="SEF55029"/>
        <property type="gene ID" value="SAMN04489712_101396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF55029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="15715" checksum="F85A108EEDA3DCAF" modified="2017-01-18" version="1">MGTPQPLDVAQLRRLRLAKDIMDRDWAQPLDVDAVAARAGYSRYHFIRCFREAYGETPGRYLSRRRIERAQDLLRSANLTVTEICMMVGFSSLGSFCTRFKQQVGMTPAQFRARARRDGPAPIPGCFVLLWAGGFRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T1L7</accession>
    <name>A0A1H5T1L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetracyclin repressor, C-terminal all-alpha domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56675">
        <property type="protein sequence ID" value="SEF56675"/>
        <property type="gene ID" value="SAMN04489712_101446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="TetR_C_1" evidence="3">
        <location>
            <begin position="84"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF56675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="26780" checksum="81028282C3EDFE6C" modified="2017-01-18" version="1">MTEGGNARPRAVPGRSGRRVGRPARIDRAAIARAAAELPLEELTMRAVAERLGVSVAGLYHHVGGREELLRLAAEQSALRMTLPHDEGQHWAVWCYQWADYIRRAFVADPELLKQYIDGAFGAEVMAEHIDAAIGLCVRQGFTERDAFAIYELLSECALGAAISEIRAVRADRAGEPMDLEMRGLLARSEPAALPNLRRMLASGTLIRPSFADRVAGVLAGVAVRHGADWREVVRLVRSAASEPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T2Y5</accession>
    <name>A0A1H5T2Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase (NAD+)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57139">
        <property type="protein sequence ID" value="SEF57139"/>
        <property type="gene ID" value="SAMN04489712_101461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026460">
        <property type="entry name" value="Aldehyde_dehydrogenase_Rv0768"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04284">
        <property type="entry name" value="aldehy_Rv0768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="21"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF57139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="488" mass="51496" checksum="F18E68380D7B0BD0" modified="2017-01-18" version="1">MPDVAREERMLVGGRLVTASDGGVFGNIDPATEEELGVTADGTAADMDAAISAARRAFDETGWADDPQFRVRCLRQLQQALTAHAEELRATIVAEVGSPVALTRGAQLDTPVEGIGWVADLAEGYSWVSDLGVAEPYGIRSHRYLRREPIGVVGAITPWNFPMQINLAKIAPALAAGNTVVLKPAPDTPWTATLLGRLAAEETDLPPGVLNVVTSSRHELGHQLAEDGRVDMISFTGSTATGRTVMATGAGNLKKVFLELGGKSALVALDDADMKAVVGNAAFQITTHAGQGCAILTRLVLPRSRYDEGVEMLVETLRGWPYGDPADPGNLMGPLISERQRRRVLGYIGTGVAEGARVALGGGVPEHLPTGYYVEPTVLADVDENATVAQEEIFGPVICVLAHDGDDDAVRIANNSRYGLSGMVISASAERARSAAHRIRTGTISVNGGLYYGADVPFGGYRQSGVGRESGLAGFEEYLEIKAIAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T5C7</accession>
    <name>A0A1H5T5C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57964">
        <property type="protein sequence ID" value="SEF57964"/>
        <property type="gene ID" value="SAMN04489712_101489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF57964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="227" mass="25025" checksum="E3291D0184EC0EF7" modified="2017-01-18" version="1">MGAQRDDDPDRPESTPGPSFDIPAGGSHGPARALESLSGIAAPLLAAAAVTVIGVIVQQPSSLAWPSLALTLLVLSAIALIAAVQLGFWARAHVVTPAELAEWWPMLKPEDRWRRVRETQWRAAAHYRRWDDATRYAYSAGIVLLWLGIGVALVPDDPSVYRWVPAVLAWLAALAEIIWSLAALMSPNGRCRVLGLRRLAEWVRRPHYVDPPPEVWPYAPDRDPFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T5Z4</accession>
    <name>A0A1H5T5Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58220">
        <property type="protein sequence ID" value="SEF58220"/>
        <property type="gene ID" value="SAMN04489712_101497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF58220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="27748" checksum="D3E76E1FFD2F2C6D" modified="2017-01-18" version="1">MSDTLPSTIAAIAEELPSTHLAAWCRVLRTAPGPTPSVEAELLEARPGYAMAGTARRLVDAWRRAGATGDAIALALEAAAVVGRDRAAHASTIAVSGPTSDAVPVRLTSQVALEVIRDAGDRLLVVSFAAHGVAAIITELTLAADRGVHVDLVLETSVAAGGTLAGPDAARVFRSLADHDRVRFWYWPQERRPVTGRSRAALHAKLIAADEHTALLGSANLTDRALDGNLEIGVVLREPAAVRSIVRHFRALMRPGTGPLAPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TG45</accession>
    <name>A0A1H5TG45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61061">
        <property type="protein sequence ID" value="SEF61061"/>
        <property type="gene ID" value="SAMN04489712_101583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF61061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="456" mass="51593" checksum="281148847D75DA74" modified="2017-01-18" version="1">MTLSDLGAKVGRAPSQLSLLENGRREPKLSLLQSLAAALEVPVEELLRRQPPSRRAQLEIALEEAQRDPLYQSLGLSYLKVGKRMPNDVIEHILALYEELKRSRTKPTASPEEARKANAELRRQMHERGNYFGEIEQVAARTLGAVGYRGGAVSQGMLMSLVQHFGFDLRYVQDLPHSVRSVTDLRNRRIYLEREQLGMHTPRTILMQTLGHIALDHDVPRDFADFLRQRVEANYFGAAMLMPESAVVPYLQEAKAARELSVEDLADVFSVSYEMAAHRFTNVATHHLGLQSHFTKNDESGTIYKAYANDGLIFPQDSDGAIEGQRMCRQWAGRHVFAAPDRFSVYYQYTDTPNGTYWCLSHIDPSHERDFAITLGVRFEDSRWFRGRETTNRVRSSCPDGDCCQRPPAELAQRWEGMAWPSARAHSHVLSVLPPGAFPGVDDADVYEFLDRHAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TMG9</accession>
    <name>A0A1H5TMG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63217">
        <property type="protein sequence ID" value="SEF63217"/>
        <property type="gene ID" value="SAMN04489712_101653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF63217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="39109" checksum="8161DD356ABC43A9" modified="2017-01-18" version="1">MALTNDRPIFVVGCPRSGTTMLQLMLHGHPRIAIPPETRFLIPAYEARGEFGDLSDPSNRERLARWIVERKRTRFADLGLDPGQVVDEIVAGPGTLGSALGIVLRAYARRFGKDRWGDKRPGYFQSIPVLVRLFPDAQIVHLIRDGRDCVASLKEMPWYRQDSFHALATWIEAVEAGRRAARVLGPGSYHEMRYEDLIDDPERELTGLCRFLQVDYDPRMADPSAMASEAVPSRKTWHRRTHEKVSAARSGTWDRRLEPWEIALCEAEAGPHLRSLGYELSGAARPSAGDRARFLRVAARRRLAAHKRRIRDRWQRLHEPSPVEALLTSGQRAAVEGERRDGLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TUR4</accession>
    <name>A0A1H5TUR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epimerase EvaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66533">
        <property type="protein sequence ID" value="SEF66533"/>
        <property type="gene ID" value="SAMN04489712_101754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="4">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF66533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="21982" checksum="F642DE3081E8D8EB" modified="2017-01-18" version="1">MQFRKLAVDGAFEFRPPVFTDERGLFVSPFQEAALREAMGHGLFPVAQTNHSRSRGGVVRGAHFTRTPPGIAKYVYCARGRALDLVIDIRVGSPTFGLSDFSVLDPEEFRAMYFPVGVAHAFVALEDDTVMAYMLSGEYVKENELALSVFDPALELPIPADIDPILSERDRAAPTLAKLEADGVLPGYAECLQIERALYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V7E7</accession>
    <name>A0A1H5V7E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83285">
        <property type="protein sequence ID" value="SEF83285"/>
        <property type="gene ID" value="SAMN04489712_102202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="245"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF83285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="440" mass="46183" checksum="03CF098C7250AF37" modified="2017-01-18" version="1">MSTSAQAGPSRRHGWQRFDSGPLAVVAVAGTLVVVAVATVTAGGLVQPQVAVIFGVLVAIGELFRMVMSGNREVAPIASAGALGYALLTTVGPERAGHPALQVVAVAAAGMFVGSLPHVAVGRSPRLDAMARRLLTIAVVALVFRPLASLKLEWEVLLCLMAVTLVASCFLEVCIAALIRAEAVRARFGIALRDEMNAKMALCAAVGATAMLIVVSTSVMGRAALLVFTAPILVTQFAFRRYAGIRATYLQTVRALSRVTEVGGYVEAGHSHRVSRLAVAMGRELGMAEEELLELEYAALMHDIGQLSLGDPIPGGATVLASPNEQRRIAELGAEVIKETGVLDRVAYIVRRQSDPYRATPAGAGTPDGNGAAVPSPQPPPPLASRIIKAANAYDDLVGESSDRDRGAAVLERLRLDSAVEYDPTVVEALARVVGRRRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VDV6</accession>
    <name>A0A1H5VDV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84981">
        <property type="protein sequence ID" value="SEF84981"/>
        <property type="gene ID" value="SAMN04489712_102262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="2">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF84981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="16094" checksum="8235D2E67A3C5E91" modified="2017-01-18" version="1">MMPRRTGDPLRRAVIRAEPQPGRWRGRRRSRQNRVVQREPDEFAELVLDVVERIPPGRVMSYGDVAELLERGGPRQVGRVMALWGGGVPWWRVIRADGSPPAGHERRALEEYRVEGTPLRPDGARVDMRSARWDGRPARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VG05</accession>
    <name>A0A1H5VG05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional hydroxylase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85437">
        <property type="protein sequence ID" value="SEF85437"/>
        <property type="gene ID" value="SAMN04489712_102280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF85437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="486" mass="51515" checksum="8FB90F15509C2805" modified="2017-01-18" version="1">MDAEVIIAGAGPAGLMLAGELRLGGVDVVVVERSPRPAPESRALGFTARTMEVFAQRGILPLFGKPATTPFGHFGGVPLDIGVLDAAHFAVLGVPQSRTEAVLTEWATGLGVRILRGHELISLSNNGENVEATIHRTGENGSPEHLRAAYLVGCDGGRSTVRRLAGFDFPGTPGTVETLQADVRGVDVAPRPPGTWTPGGMVIAAPIGDGITRVILCERGAVPRDRTAPVTFAELAAVWKRLTGEDIGHGEPVWVTAATNATRQVTEYRRGRVLLAGDAAHIHLPTGGQGLNVSIQDSANLGWKLAAQVRGWAPPGLLDSYHDERHPVGTRLLLNTRAQGLLVLGGEEMQPLRDVLTELVAFEDVARHLAGMVTGLDVRYDVGPGDHRLLGLRMPHHELKTADGAVSIARLLYPARGLLLDLADDPRLRRAAAGWADRVDVVTASPGPLEGTDALLIRPDGHVVWAAPGCGEPGPALRRWFGDPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VQY7</accession>
    <name>A0A1H5VQY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89378">
        <property type="protein sequence ID" value="SEF89378"/>
        <property type="gene ID" value="SAMN04489712_102412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF89378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="69" mass="6897" checksum="D3492148DD4E0CEE" modified="2017-01-18" version="1">MGTSTIWPIAGLAYGTALGIATAFGGWPGFVAVLVFGVIGFLIGRVLAGDLDLGEVFGAGRTRGRGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VS60</accession>
    <name>A0A1H5VS60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyl transferase AbiEii toxin, Type IV TA system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90165">
        <property type="protein sequence ID" value="SEF90165"/>
        <property type="gene ID" value="SAMN04489712_102439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF90165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="228" mass="24692" checksum="8AE9A42BEB96C5D5" modified="2017-01-18" version="1">MNDALQRRLIEAGAAVCAEFCLALAGGHALRAHGLIERASENIDLAVTEPLPLPEVAEAVAAAYRGHGFEARVGEPDGDAYAGLTVGDPATGEVCDVNLLKVPLRMRPVRVGRCPVVAYEDAIGLKVGALAGRLVARDLVDVASVAGDYGYERLEWLGGCNAPDFCLERLADRLTCHELMPEAEFERYGLDEAAIRRVKRFAAEWAHDINMRLYEDAAFEKDGTDLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VW63</accession>
    <name>A0A1H5VW63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_102486</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91450">
        <property type="protein sequence ID" value="SEF91450"/>
        <property type="gene ID" value="SAMN04489712_102486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="211"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEF91450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="398" mass="42174" checksum="CA3C64B77276A2F3" modified="2017-01-18" version="1">MSTAFPPAHHAWERSLRIWDALTLVTVLATMGVIWFGDAPYARRLAAVSLLLTVLPLYVVLVRPVVRCGPQGGRRAVGYVVTAVTLFSVATWLAPASWGVAFTLIPHCYMLLPTRWAVCAVAALNLGPGVPTLLGDEDRGRDVAGLLAGTVMITTFSAVFGLWIDRIIQQSRERAELIEQLTASRAEVARLSREAGVAAERERLTGEIHDTLAQGFTSILMLLQGAEALLEPEHPARRPVGLAARTARENLAEARALVAALPPAPLEEAPLTEALRRLAERFGEVGGASSFEVEGPPRALAPSLDVVLLRAAQEALANVRKHAAARSVALRLSYGGDEVRLTVCDDGRGFDPAAVTTGPDGGFGLAGLRQRVEQIGGTVDIASAPGAGTTVAVRLTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VWD9</accession>
    <name>A0A1H5VWD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91530">
        <property type="protein sequence ID" value="SEF91530"/>
        <property type="gene ID" value="SAMN04489712_102489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF91530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="36" mass="4149" checksum="205540ED3DA9E656" modified="2017-01-18" version="1">MQHPDISRAIMQDRVRRMREEAKAAAKAAKAKGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W0S6</accession>
    <name>A0A1H5W0S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93013">
        <property type="protein sequence ID" value="SEF93013"/>
        <property type="gene ID" value="SAMN04489712_102544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF93013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="466" mass="50413" checksum="7F5CDE8ACC068FA0" modified="2017-01-18" version="1">MDPQIHTHESTPASRPLASMTAETLLTRDFDSRPALVYERLRGKYGAVAPVDLLGVPVWLVLGYAEVLEVLRNDRGIWSKNPDDWPAFGKGEVPADWPLRPTYASRGVSYSEGREHAEFREMWSAALRPFQDRSQPQARLLEEEVRRYADELLSLLAESGQSGWADLSAQYVRPLMLMVCNRLIGFGVGTEEALMDMWRVTDAGPDAPEATARLAAMLTEVIVAKRQQPGDDLTSAMLAARADLPVEQLAAEIGMLLGVVGDLTGSLICNTIVEVIVGNTAARASLAGGMVRETVNRAAMANPANNNLTLRFATADTVLGGTVIMAGDPVMLSVAAAHADPRFAQALDPSSVHSSRAHLAWGAGPHQCPGDELATTLVTIAVERLFERMAGLELALPADQLPWRASPIMRGLRALPVRFRLREFPPQAPVPATGDEPRAEAEGPAAGTVSRSTLSRLVRALLRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WY19</accession>
    <name>A0A1H5WY19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04401">
        <property type="protein sequence ID" value="SEG04401"/>
        <property type="gene ID" value="SAMN04489712_10311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG04401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="8448" checksum="33F4919682BB03EB" modified="2017-01-18" version="1">MCERRADVQGLSDLELYVYDAVASADTGGGAVGDTEIAEIAAAAGHGEDEVRRALDRLVSLNHLRSHSAGYTLGPHDWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WYH3</accession>
    <name>A0A1H5WYH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine synthase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04140">
        <property type="protein sequence ID" value="SEG04140"/>
        <property type="gene ID" value="SAMN04489712_1033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023927">
        <property type="entry name" value="SbnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03945">
        <property type="entry name" value="PLP_SbnA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="4">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG04140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="329" mass="35557" checksum="566801370ADD852C" modified="2017-01-18" version="1">MPIICSPQDFNVEDLYVDLRPVLGHPLFLKCEGFNFAGSVKLKAAGEMVAAAERDGLLTPGSVIVESSSGNLGIALSIIAASRGYRFLCVTDPRCNPASMRVMRALGAEVRVVSRQDANGGYLESRIRYVRDLCAADGRYVWLNQYANRNNWMAHYRGTAPAIDRQFPDLEVLFVGAGTTGTLMGCARYFRELRRPVTIVAVDAVGSVTFGGVPERRLVPGLGTSARPALVDESYIDDVVHVPEADTIRTVHRLAAKGFLFGGSTGTVVSGAARWLAAKYPGEQPVAVAIAPDLGERYLDSIYEEHWVREHFGDLADGLALPGADILGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X838</accession>
    <name>A0A1H5X838_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07537">
        <property type="protein sequence ID" value="SEG07537"/>
        <property type="gene ID" value="SAMN04489712_103117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG07537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="20397" checksum="5FBA324E5640A389" modified="2017-01-18" version="1">MTSVKIVVGGGFGVGKTTFVGSVSEIMPLTTEAVMTAASADIDDLTAVPDKTTTTVAMDFGRVTLDSDLILYLFGTPGQHRFWFMWDDLVRGAIGAVVLVDTRRLSDCFAAIDYFEEAGLPYIVGVNGFHGEFPHSAEEIREALTVASHVPIVQVDARNRESTKQALIVLVQHAMTVHSGGSPVAAAPGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YMW6</accession>
    <name>A0A1H5YMW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25491">
        <property type="protein sequence ID" value="SEG25491"/>
        <property type="gene ID" value="SAMN04489712_10496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG25491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="199" mass="22483" checksum="8ED0D86CDFEDEAB2" modified="2017-01-18" version="1">MSRRILDEAARLFYEDGFPATSVRKITAACGVTAGSLYNHYQSKEEVLYAILKRAHEDSERLLEEGLLRGGDRADRQLAELVRELTLFHTERRIEGLVARTEWRHLPPEQAKEVLDAQRRVRRIFERTLERGLAAGRFRLSDPRSSRPAPVDVVAKAILDMCINAGQWFRPEGTVSARELADQYAFLALQLVGAGPPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YS31</accession>
    <name>A0A1H5YS31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein, ATPase of CpaF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26297">
        <property type="protein sequence ID" value="SEG26297"/>
        <property type="gene ID" value="SAMN04489712_104128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="103"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG26297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="456" mass="49611" checksum="8D9ED6A60CD316A5" modified="2017-01-18" version="1">MTGYGWAGLDAVGHTLSDSLAANGDGASTGPVDVWAAVRQVGQQLADVLGDDVDRDEARQLIAAQVQMWAHEQMVAGRRLLSAEEQRRMAQAVFDHRFGLGPLQPFLERSDVENIVVNGCRQTWITYTNGAKEPGPPVAATDEDLVEWIQLLARRGNSGREFSHANPLLDVALVDGVRLAVVHWVSRHPHLAIRVHRLVDIALEQLTGLGTLTGPLEQFLRAAIRARRNVIVCGEVNTGKTTLVRALANEIPADERIITLESDFELFLDDPRLAHRHHDVVALEARQANAEGAGQVRLQDLVPACLRLNPDRVIVGEARHGELAPMLEVMYSGARGSMCTLHVHRPEHVFNRVVQLGRRADLGLSPEDLHLMFGLAEPLVVYVQRDPVTNARYVSQVMEVRPPGDSVEPARNHIFVPGPGGRATPSGGHISAELLAELSACGFDPALLAPDGGGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YSW6</accession>
    <name>A0A1H5YSW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26406">
        <property type="protein sequence ID" value="SEG26406"/>
        <property type="gene ID" value="SAMN04489712_104133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="48" mass="5083" checksum="007AE44BDF7C2153" modified="2017-01-18" version="1">MIPDDLLKIVICIGLGHVITLAFGLLCGFALGLDRAADLARCRCKDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YTN0</accession>
    <name>A0A1H5YTN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27072">
        <property type="protein sequence ID" value="SEG27072"/>
        <property type="gene ID" value="SAMN04489712_104162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290881" evidence="2">
        <location>
            <begin position="34"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG27072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="450" mass="45556" checksum="33E71ADF4C16CCA4" modified="2017-01-18" version="1">MRTWVKVSARAVMLTAGFAAFGAGTVFPDAAHADTDLHLIIGDRNVPPVSATVEVGDHSVSVGEAHGAGSLTRNELPALPRPATPAPHAATPTLPQAAKDSQDVLDVPELPAGPDGLRIPNVPGHPSEIRIPETPAIIDVEELEILDVEGLEILPGVEAPELPGNLTGGLRVGPKPKGPHSAGRAPEHMGSMPQTVQSGGDSHLGPVVLPPTGHLPVRPDVLPALPSSALIRLPARPDTPLKGADRIDPALSQPGTTAHRLLFPRTPVQVTTAGTPRLSLPGLPELPKPPINGGIGEPEYQISADRLSGGVPEITTHPLRTTGQTAEATQNAPSRVLEPAGELSGSAGQVRETAGQAIEAAQNVPGQVPGAADRVLEEVGQVAEAAEGVPGRVPGAAGRVLERAGQVAEGVSGLVALGAGGVDERAGSGAGGTDGVRLPDGSMAKPVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YVD8</accession>
    <name>A0A1H5YVD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27405">
        <property type="protein sequence ID" value="SEG27405"/>
        <property type="gene ID" value="SAMN04489712_104176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG27405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="15949" checksum="00B751B0D697B51A" modified="2017-01-18" version="1">MHPSNQREPRLYSANQRQAANWSRDPRVEITSRTLRYPANWGESWCQERPREKGVDVLVALDVVDLAQQGTYDVVILASHDTDMEPAIERALYRGRSKVETGGWRGARRLKPGRRNVWRATLGGADFVRVRDRRDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXX1</accession>
    <name>A0A1H5YXX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28660">
        <property type="protein sequence ID" value="SEG28660"/>
        <property type="gene ID" value="SAMN04489712_104232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG28660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="26416" checksum="959FC76A8EBC22A7" modified="2017-01-18" version="1">MTSTTDPVRTLEAALDGTLDERGRRWLEQAIGRVAERGQAVLEVFPAAGRSCGRGPLPGMPGWTVDQAARARLLLALPQEGAPLGELLFDVYRYGDAAERIAVLKALAVLDGADPAEGGADLAEGGRAPGGRLGGHGLPIVRDALRTNDTRLIEAAVGPYAAGHLADDEFRQAVLKCVFVGVPLSAVAGLDRRADRELARMLADYARERTVAGRDVPQDVWPVVERHPEVMQDRGRQDVHRPERIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z2D3</accession>
    <name>A0A1H5Z2D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_104305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30354">
        <property type="protein sequence ID" value="SEG30354"/>
        <property type="gene ID" value="SAMN04489712_104305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="36"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG30354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="29976" checksum="F6DB8B6884C23F2D" modified="2017-01-18" version="1">MTGHRAHAVRVGVARGWTEFRLGLKNPQDLGFYLFVAAGVLLYLFWNRDDEVAGTSLPVPSAALPGILAMLVAFGAVTGPAYALAVEREDGTLLRARAVPHGVTGYVAGQVLLQTMQVFPMFAVILGPSLLLFDGVAPRGAAGWLTVLWATALGLAAMMPVGIVIGSLASGPQRVGTWGLLPVLALAGVSGVLLPMDALWGWVRAVAQLFPVYWVGLGMRSAFLPDAAAVLEIGGSWRTWQAVCVPVAWAVAGMVVAPVVLRRAARRACGSRMAADRESAARSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z9X9</accession>
    <name>A0A1H5Z9X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33102">
        <property type="protein sequence ID" value="SEG33102"/>
        <property type="gene ID" value="SAMN04489712_104440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG33102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="609" mass="62929" checksum="A607862C35040662" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZES1</accession>
    <name>A0A1H5ZES1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_104506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34580">
        <property type="protein sequence ID" value="SEG34580"/>
        <property type="gene ID" value="SAMN04489712_104506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG34580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="42758" checksum="E29C778C97F93E2E" modified="2017-01-18" version="1">MAEQVTDDAATGPRLERGDDGRLMAGVCRGLAEHLGLDVVVVRLAFVLLNATGGLGVAAYAAFWLLVPQRGDTARTGARHRDWVQLLAYGALSAGLSSVAWGAGLARVALWPLLVGGIGAAILWQQADRDQRQRWVRTTTVPLRRLWLRSLLGLALVIGGISGFLVQNVQVAQIREVLIATVVLATGLAVIATPWVVRLWQDLDAERRERIRSQERAELAAHIHDSVLHTLTLIQRNAADSREVQRLARSQERTLRNWLYQPQADPDRTFAAAVRETAGEVEDDHGVPIEVVCVGDCPLDPRLGAALQAAREAMVNAAKYSEAPSVSVYAEVEGDDVAIFVRDRGKGFDMDGIPQDRMGVRGSIIGRMERNGGKATVRTAPGEGTEVRLEMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZX01</accession>
    <name>A0A1H5ZX01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/amide ABC transporter membrane protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40672">
        <property type="protein sequence ID" value="SEG40672"/>
        <property type="gene ID" value="SAMN04489712_10545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG40672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="363" mass="38026" checksum="DB4A365D47252646" modified="2017-01-18" version="1">MSETANTANTASTANEAAAEPAEVQAPGRDASGEPGSWGARLRDAAVERWRPIALAALLLAACYAPFQLVPFRVFQLTMVLVYAVALLGLNLLVGHAGQISLGHGAFFAVGAYAAALMLDRWDVPYLLTLPVAAAVAFVLGLGLGVPAVRLHGLYLALVTLSIAVFLVPLLKRFESVTGGSMGLTLTKPAPPAWTGLAEDQWLYFLALAVAVAAFLLARNLLRSRVGRALHAVRDNEAAAEVMGVRLPFYKTLAFAWSAMFAGAAGCVYTWVIGFVSPDSFPVTLSITLLAGIVVGGLGSLSGPLLGGLFVMFVPSWSQDINKAAPGVIFGLLIIAVMYVAPTGLAGLAGRAAGRIRRTLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A273</accession>
    <name>A0A1H6A273_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42551">
        <property type="protein sequence ID" value="SEG42551"/>
        <property type="gene ID" value="SAMN04489712_105145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024486">
        <property type="entry name" value="DUF2617"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10936">
        <property type="entry name" value="DUF2617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG42551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="17786" checksum="6444C7310DF0AECF" modified="2017-01-18" version="1">MHTALDTPYLDTRADALSFALGLAPLDALAVLPVERAGIRVEMRLLGASHQVFAGPVSETVACLPGRPVPLPGGMRTEVDGWTYDFGASVQSYDSGLTFTATVRELCARLADRDDALTGTFPGSPYAVTALALDGDPGTGTLGWRTWHAYPQTRQIVVTRTLLEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A3M6</accession>
    <name>A0A1H6A3M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43328">
        <property type="protein sequence ID" value="SEG43328"/>
        <property type="gene ID" value="SAMN04489712_105190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG43328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="175" mass="18964" checksum="C40770D4CF98EFF0" modified="2017-01-18" version="1">MTDRAPGWALGPWAAPHLLFNFLEMWRGRSPGTRSWRPSVLPGPMQAARVLLYAAAALTVIAALDAWIAADGTAGLGQVIALSVLAVPCVLLARRAAHPGPWTWSAILALETFSLLWQLGRIASGDPFGLLGLTFPIALIVLVARWAVRGHLRVRPWQRRNLRPRTADCGSASSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXK2</accession>
    <name>A0A1H6AXK2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52805">
        <property type="protein sequence ID" value="SEG52805"/>
        <property type="gene ID" value="SAMN04489712_10655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="7272" checksum="2F2451AAF8E675D5" modified="2017-01-18" version="1">MSIKYARWRKSSHSAPNGDCVEVGISHMGAIGVRDTKQDGTGPVLEFTRPEWAAFLSAIRSADPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYU1</accession>
    <name>A0A1H6AYU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F5/8 type C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53544">
        <property type="protein sequence ID" value="SEG53544"/>
        <property type="gene ID" value="SAMN04489712_10699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293155" evidence="2">
        <location>
            <begin position="27"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="30"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG53544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="720" mass="76176" checksum="F014A93DF6960419" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2Q6</accession>
    <name>A0A1H6B2Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellulase (Glycosyl hydrolase family 5)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55143">
        <property type="protein sequence ID" value="SEG55143"/>
        <property type="gene ID" value="SAMN04489712_106207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="100"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG55143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="675" mass="72919" checksum="0244916991788812" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B4Q2</accession>
    <name>A0A1H6B4Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemoglobin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55590">
        <property type="protein sequence ID" value="SEG55590"/>
        <property type="gene ID" value="SAMN04489712_106242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG55590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="127" mass="15059" checksum="E51A2BC599D95CCF" modified="2017-01-18" version="1">MAQEVTFYEAVGGEETFRRLVHRFYQGVADDPLLRPLYPEEDLGPAEERLRLFLIQYWGGPRTYSIQRGHPRLRMRHVPFTIGTAERDAWLRHMRDALDELDLPEQLEQMLWEYLEMAARSLINSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6B7</accession>
    <name>A0A1H6B6B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56393">
        <property type="protein sequence ID" value="SEG56393"/>
        <property type="gene ID" value="SAMN04489712_106309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG56393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="20665" checksum="AA2FFC23DADEF9E9" modified="2017-01-18" version="1">MSGLNRHRSRALCDQVVERLDLPASATYRDACRRTGEVMSELLGAQVELKFVGLHNTPFSGATVRRADGTYVVYCARSRSWYHRLGILLHELAHVLLGHDPVSFAGGSGPHRLAPHLPGKMARILAGRTNHVGEEERQAEELADRLLERLTERHARRPERPAPEVAPHVRRIAEGLAPYPADTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BHM9</accession>
    <name>A0A1H6BHM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59736">
        <property type="protein sequence ID" value="SEG59736"/>
        <property type="gene ID" value="SAMN04489712_10787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="419" mass="44463" checksum="1F03D01C84EC0559" modified="2017-01-18" version="1">MRGAGEQRRRGRRDTAAQAARTAALAARESAASAFYEMDQAQRYVGGRVTVFADLDPAAAVSAQREFAALDERADAASASYIAVLDSHDLNDEERSAAEYDAARRALTAVTEGLTKATADLNGFAARLGTRLAGLEAALDQLPPRLTAARDAVAAAEEAVSRARAAGLDAEEPAAGLTRARDTLARLSAQGLGGLGLSGALDAAEEVRRLAEAAREQAEELPKAAEKVRHSLASVRTRAQVVAGRAGPVREAMSRLLRGYSQACWQDLRNAPAAIEEGVARAQERIAEAEAHVGHGRWRQAQQAVTAARTELSAADRRAGQVTGRLAELDAAAADPAGPAEAARFVVRDAQKLVVTAGSAISPQHARTLDGLVERLEAAPQRLRGAHPDYWAYLRELESIKTAARDVVERVRAERAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BI50</accession>
    <name>A0A1H6BI50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60390">
        <property type="protein sequence ID" value="SEG60390"/>
        <property type="gene ID" value="SAMN04489712_107128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="82" mass="8777" checksum="EDADF617D325155A" modified="2017-01-18" version="1">MTVVRSGGFAGIDRRGESDTASDPVLRGLVDRVDLGRVPPPGRIPDQFVYEIDIDGRVATVGEAQLTGPLRELVHHVLDGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLB2</accession>
    <name>A0A1H6BLB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_107213</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61432">
        <property type="protein sequence ID" value="SEG61432"/>
        <property type="gene ID" value="SAMN04489712_107213"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG61432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="197" mass="20932" checksum="E3D9A2E9932A55CB" modified="2017-01-18" version="1">MSTVGPEPAAVPGPEPAAPPSVYNVANLLTLVRILLVPVFVWLLFVDGTGWRVAAFVVFAVASVTDKIDGDLARKYDLVTDFGKIADPIADKALTGAALIGLSVLGELWWWVTAVILAREIGITLLRLVVIRYGVIPASKGGKLKTLLQVVAIGLFLLPGPLDPLRWATMAAAVAVTVVTGVDYVVQAWRLRRAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BP42</accession>
    <name>A0A1H6BP42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62461">
        <property type="protein sequence ID" value="SEG62461"/>
        <property type="gene ID" value="SAMN04489712_107298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293931" evidence="1">
        <location>
            <begin position="26"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="86"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG62461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="521" mass="56559" checksum="50CBBD8710222D12" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUM0</accession>
    <name>A0A1H6BUM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64394">
        <property type="protein sequence ID" value="SEG64394"/>
        <property type="gene ID" value="SAMN04489712_10820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="219"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="374"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="471"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="577"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG64394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="732" mass="77929" checksum="89DB38D6F2D8643D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BV63</accession>
    <name>A0A1H6BV63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_10814</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64327">
        <property type="protein sequence ID" value="SEG64327"/>
        <property type="gene ID" value="SAMN04489712_10814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG64327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="576" mass="61034" checksum="FB2C68C4376DE9A8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYU9</accession>
    <name>A0A1H6BYU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65647">
        <property type="protein sequence ID" value="SEG65647"/>
        <property type="gene ID" value="SAMN04489712_108123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025637">
        <property type="entry name" value="DUF4333"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14230">
        <property type="entry name" value="DUF4333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294391" evidence="2">
        <location>
            <begin position="33"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4333" evidence="3">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4333" evidence="3">
        <location>
            <begin position="132"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG65647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="211" mass="21557" checksum="6AACD92AC62E3E5E" modified="2017-01-18" version="1">MRKLLAPALLGTALVAGLTTGCTALLDKTVAASEVEAQIAGKLAGQLGGKPRSVSCPADLRGEVGATLQCSLVTADGTERVVNITVTSVDGDQINYDIKSPAPQQTAPTTPTEPTTPTQPTTPGTGDTGAPTVPVVTQAQVEAEALRQLAPQLDGVPRSVVCPGDLRGEVGVTMECTLHFEDGTWRPTTITVTSVVGTTVNFNIRLGGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1E1</accession>
    <name>A0A1H6C1E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66186">
        <property type="protein sequence ID" value="SEG66186"/>
        <property type="gene ID" value="SAMN04489712_108171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="9"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG66186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="454" mass="46912" checksum="6151F9EF72CF3BB3" modified="2017-01-18" version="1">MSPFDYEVDVAVVGGGACGLVTALRAARSPGLTVAVFEKSTREGCNAQISSGSLAAGGTRFQRAAGIDDSPARHARDILAVSGDTEAAPLVHAVCEAAPRYVEWLADELGHPLELGLDMARSGQSVPRLHTDVGRGGGALLVRTLRRAVETAANIAFLDATPGTGLLSEDGRVTGVLVRENGRTRRVGARAVVLAADGFAANTEMLAEHCPDACGAFYGGVGTSTGDAISWGVALGAGTRNMSAYLGHGMIVPGHGTRLNPVLPFLGALLVGSDGRRFADERAQGYSRLGRIIAARPDGRAVLIWDDRMHDTAMNSELMRQSQEAGAFRRHPDLAALATALALPAEALAETLRMFRAVSSDGDHGPLSFPLYAARVTHGILATQGGLTVDTTGHVLHASGRRIPNLYAGGGSAAGISGPSTEGYMSGNGLLAALGLGWIIGNHLAVTLPHSART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1J7</accession>
    <name>A0A1H6C1J7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="7" type="ORF">SAMN04489712_108228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66831">
        <property type="protein sequence ID" value="SEG66831"/>
        <property type="gene ID" value="SAMN04489712_108228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG66831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="31425" checksum="53D7BA9FFE8D48FC" modified="2017-01-18" version="1">MPLMDHLRELRNRLIKAILGLLVGTVVGWILFQPAWDFLKEPYCALPASRDLNGHCSLVVNGIFSSFFLRLKIAFIIGLVISAPVWLYQLWAFVAPGLYRQERRWTYVFLGAAVPLFFVGTALAYLTVDKGLSIFLGFVPEDVAALITVDHYLGYVLAMLLVFGLTFELPLFVVVLNMAGVLSSARIRRSQRLIVFGIFVFAAVATPSADPFTMLALALPTVLLFEVAAFLAFLNDRRRGRRPDPYAELSDDEAAPLDLEEIDASLEEGVGAKDGVERGERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1Q6</accession>
    <name>A0A1H6C1Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66872">
        <property type="protein sequence ID" value="SEG66872"/>
        <property type="gene ID" value="SAMN04489712_108232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="155"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG66872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="373" mass="39836" checksum="954F0442CF86306D" modified="2017-01-18" version="1">MNPDVTTELYPPARLAQVQEATAEAGLGALLLTPGPDLRYVTGYDAIQLERLTCLVVPGEGEPFLVVPRLELAAAQASPAGALGVEMVPWDETDDPYALVARRLPSGLAAVGLADRMWAVMALRFRDAMPGARQVPAGRVMGRLRVRKSPAEVAALREAGAAIDRVHRLVPGLLKAGRTEREVGRDIAEAIVAEGHARVDFVIVGSGPNGASPHHELSDRVIGHGEPVVVDIGGTMPSGYCSDETRNYCVGEPPADYTAYYEVLRRAQQAACEAVRPGVTPEAVDAAARDVIADAGYGEFFIHRTGHGIGLETHEDPYIVAGNTEPLRPGMAFSIEPGIYPGEHGARIEDIVVCTEDGFERMNLIDRALTIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9I6</accession>
    <name>A0A1H6C9I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69568">
        <property type="protein sequence ID" value="SEG69568"/>
        <property type="gene ID" value="SAMN04489712_10997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="65"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="26808" checksum="69D83F466E9B8A4B" modified="2017-01-18" version="1">MKRRPAGMPLILRYRSVGRTERGPARPNVPPEVFERQMDWLYRNGLQGVSVGELRAAWRAGRARGLVGLTFDGGYADFATRAAPVLLRRGFTATVFVAAAEIGGESTWDTGPRRRLMSEDQIHRVVGKGMELGSHGLRYVSLPGTDDEELVEELTRGRSMLEDLTGGPVTGFAYPYGHVLRREMDAVRKAGYEYACAVWRSLLNGDHALPRTRMGDHDRGVRMWAKVFRHQLVWRTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAY9</accession>
    <name>A0A1H6CAY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine phosphatase RsbU, regulator of sigma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_109145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70149">
        <property type="protein sequence ID" value="SEG70149"/>
        <property type="gene ID" value="SAMN04489712_109145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="5">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="510"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG70149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="811" mass="87231" checksum="D9182257931805CB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CB49</accession>
    <name>A0A1H6CB49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70083">
        <property type="protein sequence ID" value="SEG70083"/>
        <property type="gene ID" value="SAMN04489712_109140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="32"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="92" mass="9941" checksum="75457BF2A208AC74" modified="2017-01-18" version="1">MIHLSDIPWRKSRHSGPRDNCVEVASMDLSHAGWRKSQRSGNGGANCVEVADAGRVVAVRDSKDPEGGILAFQQDAWGAFAQRVKGGCYDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCD2</accession>
    <name>A0A1H6CCD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70670">
        <property type="protein sequence ID" value="SEG70670"/>
        <property type="gene ID" value="SAMN04489712_109190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="14"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG70670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="30978" checksum="D18A3E06955F7362" modified="2017-01-18" version="1">MDIVFERRGDGPPLVLLHGIGHRWQAWRPVMDRLAREREVIAVDLPGFGASPPLPDGTPYTVDTVLSVMAELFEEFGLRRPHIAGNSLGGLFSLEAADRGLVSSATVLSPAGFFTAPELRWASTVLRASRLAARTPEPLIDLLARSPKRRRALFGMIYGHPDRLEAAELLADARALRDCAGFEPTLRAGRRVRFAGACADVPVTVAWGTRDRLLLPIQALRAQQRLPNARFVWLPDCGHVPMGDDPDLVAKVLLEGSSTPLLEPVRPDGPRGLSAEAALDAGQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEG4</accession>
    <name>A0A1H6CEG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_109257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71288">
        <property type="protein sequence ID" value="SEG71288"/>
        <property type="gene ID" value="SAMN04489712_109257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG71288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="36700" checksum="3E2EA5DE773F62BC" modified="2017-01-18" version="1">MIDFALPPALEAHEPPEAHGRTRDGVRLLVARGDGIGHHAFTELPDLLNPGDLLVVNTSATLPAAVRLDKLAVHFSTPYAEDSDLWLVELRRRVGKTSRPYRGGSPGEWIPMPGGATLALVRRQTERLWQARLSTDVVPYLRRYGVPIRYGYVRRDWPATAYQTAFALDRREGSAEMPSAGRPFTPELVTRLVSRGVLMSPLSLHTGVASPEAHEPPYAERYDVPAVTADLVGHVRARGGRVIAVGTTVVRALETAAEPSGGVRPSRGWTRHVVTPETGVRVVDGLLTGLHEPKSSHLRMLTAIAGPRLLERAYEAALAESYLWHEFGDLNLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLZ2</accession>
    <name>A0A1H6CLZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73466">
        <property type="protein sequence ID" value="SEG73466"/>
        <property type="gene ID" value="SAMN04489712_110113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="452" mass="46864" checksum="2664890824417732" modified="2017-01-18" version="1">MTTGSSAGRYRLEWSGAVLHLAARRVGLRTEITLYRDGEAVAEGTGIGRVMLPLPTASATTSTDNPAAPEVTASAADVPEAAAPETGVPEMAAPGAAASAADVPEGDVPEVGEGAAKPPMVLAVAVVPGTIVRAFLMVPRPAVAEGQEAEAGEAPQDGEREMAGVEDAVGADGGGAAEKSGEAKKGSAGAGRPDEGLDEAVAELPEGLAKLVGFARAERYPFEPPPGTFAARLLAFQREHPKLYASRHVVLATGKVVLGLLGVAVFFQLILSRVIQWIIERLPNMDLPGLPLPDLDLPSIPWPHIPLPDLPDLPDVTLPGWLKAVLATAKYWIPILIAIGAAVQEVRKRKRRSAAAQSAAEPDGPPADRADATEPEPAGRATRPTGAAVRQGGEPAWRDGEPAQRAGEAVRRDGEVTRRAGETASARARPGTGEDGADTRRTGGDRQPDAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNI4</accession>
    <name>A0A1H6CNI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette, subfamily B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_110238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74531">
        <property type="protein sequence ID" value="SEG74531"/>
        <property type="gene ID" value="SAMN04489712_110238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG74531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="581" mass="62974" checksum="27A8254C1812AC38" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTZ4</accession>
    <name>A0A1H6CTZ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine deiminase</fullName>
            <shortName evidence="3">ADI</shortName>
            <ecNumber evidence="3">3.5.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arginine dihydrolase</fullName>
            <shortName evidence="3">AD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arcA</name>
        <name evidence="5" type="ORF">SAMN04489712_111162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-arginine = L-citrulline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="EC" id="3.5.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the arginine deiminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76422">
        <property type="protein sequence ID" value="SEG76422"/>
        <property type="gene ID" value="SAMN04489712_111162"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00242">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3 4">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG76422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="411" mass="45057" checksum="7F489215AA608273" modified="2017-01-18" version="1">MVGAFGTDGHRLVKVTHKYRVDSEVGRLRTVLMHRPGDELKRLTPRNNDKLLFDGIPWVGRAQEEHDAFAQALRDHGVEVLYVTELLQDTLEYEDARDEAIAGVVADPRLGDQLRPVVEGHLRELDPERLAHTLIAGLAHEELKAAHGLVYRLMDRLDFVIDPLPNLLFTRDSSAWIGSRVAVTSLAMPARRRETSLTKLIYGFHPRFRGVETVYGPALEHVEGGDILLLAPGVIAVGTGERTTPAGVERLARQVFAAGVAHTVLAVPIAQKRATMHLDTVCTMVDVDTVVMYPPVAYSLTAYVVTRDNGDLRVSPERPFLEAAAEAMGVDRLRVIDTGLDPVTAEREQWDDGNNTLAVAPRLAVAYERNTETNAQLEAAGVEVIRISGSELGSGRGGPRCMSCPLLRDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUN2</accession>
    <name>A0A1H6CUN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76558">
        <property type="protein sequence ID" value="SEG76558"/>
        <property type="gene ID" value="SAMN04489712_111178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="234" mass="24021" checksum="F4AF3145F84F60A2" modified="2017-01-18" version="1">MREPLTIAVAQPLCVSYDVVANAATHAQTVRSAGTRVVVFPEMSLTGYELDAPAITAEDPRLAPIVDACAETGSLALVGAPVQGEQGRPYIAILAVEGTGATVAYRKMWLGAAEAERFAPGGKPSVLDVDGHRLGLAICKDTGIAQHASDTAALGIDGYVAGVLEHVEDAHVPAERAHRIITSHQVWVAVASFAGSTGGGYDQAAGRSAIWTPDGNAIAQAGPEVGAIAHATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV45</accession>
    <name>A0A1H6CV45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76852">
        <property type="protein sequence ID" value="SEG76852"/>
        <property type="gene ID" value="SAMN04489712_111215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="18493" checksum="4C9D42810DF06A5D" modified="2017-01-18" version="1">MTQPDSPPTTVRPYVRRDGEGEAFWFLGNLVTVKAAGAHTRGRLTVVEFVNPPGFAPPLHRHLEEDELFYILDGTARFQCDGEDLAAGPGDLVHLPVGLPHTFVVGPDRPLRCLQITTPSGFENYVAALSEPAAERRLPDPPPADAPIDLAALGPIHARHAIELLGPPPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYL6</accession>
    <name>A0A1H6CYL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78142">
        <property type="protein sequence ID" value="SEG78142"/>
        <property type="gene ID" value="SAMN04489712_11235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG78142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="46011" checksum="7BB080BB6AB01612" modified="2017-01-18" version="1">MSVGDNAATAVERAVTDAHRREWAFVLAATARVAGDLDLAEECVQDAYLAALDAWARDGIPRKPGAWLTTTAKRKALDVLRREQVFRAKMPLLVEPDEVAMDEPDDDAIPDDRLRLIFTCCHPALARQAQVALTLRLVCGVGTGDIAKAFLVSEPTMAARVTRAKKKISAARIPYRVPDAGELPERLDAVLTVIHLLYTTGHTAASGADLVRADVVGHALNLTRMLMALMPDEPEVRGLLALLLLTDARRATRTDARGRLLRLEDQDRSAWDRAAIEEGRDLVADAFRTGRVGRYALQAAIAALHATADSYAATDWRRILRLYDDLLKVWPSPVVALNRAVAVSMVHGPQAALDEIEALRQDGRLNGYHYLPAVHADLLRRLDRPEEAAVAYRAALSLADNEAEREFLAARLAEVLDPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2K1</accession>
    <name>A0A1H6D2K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_112227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79510">
        <property type="protein sequence ID" value="SEG79510"/>
        <property type="gene ID" value="SAMN04489712_112227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012251">
        <property type="entry name" value="GlcNAc_6-SO4ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036666">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036666-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG79510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="446" mass="50657" checksum="B0B93C9564FCCAD4" modified="2017-01-18" version="1">MSRPNIVVIMTDDQDAASMAVMPNVRRLLVDQGTSYTNSYASYSLCCPSRATFMTGQYAHNHKVLDNQWPDGGYRRLPKETLPLWLGRSGYATVHIGKFLNQYGHDPEEIPPGWQEWYGLVGNFAYKMWGYRINENGTVRRYGKQKRENPKLYQTDVLANKAVNYIKRRAKSDRPFFLSFAPLAPHTEPPWKGDPDGTWRGPRPAPRHRGMFAKRPLPRPPSFNETDVKDKPRHLRPDRMSAARIKQVTADYRMRLESLQAVDEAVARIVRTVAEAGELDRTLFVFTSDNGYLLGQHRWPSNKTHPYEESIRIPLVLRGPGFAKGRKVATPVVNVDLPATILSVTGARAPVPTDGRPLQELARSNRARDVLIETGPRSSGAHWYAAIRTDRYLYVEHSTGARELYDLVTDPYQLSSKHNDPRTAPLQVTLSQRLRKLRVCSGRACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4R9</accession>
    <name>A0A1H6D4R9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_11363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80332">
        <property type="protein sequence ID" value="SEG80332"/>
        <property type="gene ID" value="SAMN04489712_11363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="8">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="9">
        <location>
            <begin position="147"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG80332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="22810" checksum="A88082FA4A35EC65" modified="2017-01-18" version="1">MAHRTPAAPSSTVPPSARERASGSRWSWFRGPSPSATVDDQVIVTELYRVYGRPLLSFVLRLTGGDRHWAEDVVQETMIRAWRSAHQLDANATSLLPWLATVARRIVIDDQRRKNARPQEAGEGPLENLHAPDGLEDLLRSVVVSEALRSLSPAHREILNETFFRDRSVNEAAKALGIPVGTVKSRVYYALRALRVALEERGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5B2</accession>
    <name>A0A1H6D5B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80500">
        <property type="protein sequence ID" value="SEG80500"/>
        <property type="gene ID" value="SAMN04489712_11393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG80500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="20931" checksum="6B6E489E0CB86AC3" modified="2017-01-18" version="1">MTESTGTPTRRTEILDAAAELFARRGYHGVSIGDLGRAVGLTGPALYRHFRGKDAVLAEILLDISHRLLAEGTRRVAAAGDPRDALDALLRWHIDFALGNPALIVVHERELDNVPEPQRHEIRRAQRAYVEEWVGVLLRLHDLPEERARAAVHATFGLLNSTPHSAGALGREAMAALLHAMATAALTRAAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6X3</accession>
    <name>A0A1H6D6X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80718">
        <property type="protein sequence ID" value="SEG80718"/>
        <property type="gene ID" value="SAMN04489712_113138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045728">
        <property type="entry name" value="DUF6082"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19560">
        <property type="entry name" value="DUF6082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="217" mass="24051" checksum="7A72923A65E30E7F" modified="2017-01-18" version="1">MPSSRRPARQGARRWSSIALILVLVAIVGAFGVSPFLLDAYDGSAAQWERRSLIGQTYGAASAILSVLALLGVVVTLVLQARETALAREEARRTAIADLLRMAMDDPDLDACWGPVPAGQDLRTRRQQLYINMIVSEWRMSFETGALGPARLRAIAAEMFSGEPGRLYWESARHRRLSTSQSRKARRFHEILDEEYRRIHPPPDRRPGGSTVGGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D817</accession>
    <name>A0A1H6D817_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Virulence factor Mce family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81440">
        <property type="protein sequence ID" value="SEG81440"/>
        <property type="gene ID" value="SAMN04489712_11457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295683" evidence="1">
        <location>
            <begin position="28"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="114"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG81440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="37564" checksum="01834306265C6C65" modified="2017-01-18" version="1">MRPRRVITAAVLAVGLALSATGCSVLGASGGYRIVVYFAKSPSLYEKSRVKVMGADVGDVEDVRVENHRVRVELLIDEHVPVPADVRATIAAESAIGERSVILYPPWKPGMARAAPDTVVPVERTEPPVEIDEVLGSFTTLAESLDPARVRGLVRTGARLLDGRGESLNDALTTTADLADGLAAQDREIVAAATGLRDLATSLNRHDAGLRRLIDAFSTTSAQLADERTRLKNLLVGLETLIRKGQVVITAYRETLPRTVSQASSLVMTLKANSASMAQAMVGLARFGDLVTNSYDPETHTITARVQLNATLRIWLQPLFDQMGWGRVPCLDQPVPGCPTTIERKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9D0</accession>
    <name>A0A1H6D9D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted ester cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81265">
        <property type="protein sequence ID" value="SEG81265"/>
        <property type="gene ID" value="SAMN04489712_11411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="149" mass="16839" checksum="1776CBC700D2620C" modified="2017-01-18" version="1">MTDKDLARTNKEILRRYYARASGRRDDAADDRLAEFFHEDVELPANTLPHGRQGLEGLREHNRYMRTVLAGGPPTVEAMIAEGDKVAVRLTLRGRVIGELMGLRPSDKEFEIEEHMIFTFRNGKVSRVDRVADRYALVEQVGQGSISIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEZ5</accession>
    <name>A0A1H6DEZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, FadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83794">
        <property type="protein sequence ID" value="SEG83794"/>
        <property type="gene ID" value="SAMN04489712_11668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG83794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28990" checksum="101F6828337B16D2" modified="2017-01-18" version="1">MELAGGEHTKIGQLRMAELVASALRERILAGGIVDGSTLPKQDQLVEEFGVSYPSVREALRILETEGFITVRRGNRGGATVHAPDIGTAGYALGLTLQAMQVKVPDLGAALATLEPLCAAHCAQRTDRGRAVVPPLRELLAEGDDCLDDGAAFTRASRKFHDTLVGFEPNATLRVVVMSLTSLWSVQEETWADVQMSRGAYPSRSDCAAAQRAHERLVTSIEQGDADEAARIAQEHLTAAQRWVCRTLKDRVIDAASSRSRMRFRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFN7</accession>
    <name>A0A1H6DFN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Monovalent cation:H+ antiporter, CPA1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_116132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="SEG84044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="SAMN04489712_116132"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:solute:proton antiporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:sodium ion transport"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
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        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0050">Antiport</keyword>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="15"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG84044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="534" mass="56544" checksum="EAB05695B1213773" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DG97</accession>
    <name>A0A1H6DG97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11714</name>
    </gene>
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        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84497">
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        <property type="gene ID" value="SAMN04489712_11714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="26374" checksum="290D1D7A00ADF55B" modified="2017-01-18" version="1">MSQPRPPAVWFTEERPRKPRLSRERIARAAVELLDAEGVTGFSMRRLAARLGAGVMSAYEYVRSKEEVLDLAMDQVFAEIELDDSGTEPWRETLTRQLHQSRQMMKRHPWAPSLMATRPLLGPNFLARSELFYAALARAGLQGPQLLAAVGTLTYYVQGYTAAENVWSGWMRDSAEEAELRRQVQDYLRDQAALYPALTRHAQLSDDDFDGQFQRGLDLVLDGIQAQLHQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGH2</accession>
    <name>A0A1H6DGH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crotonobetainyl-CoA:carnitine CoA-transferase CaiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83873">
        <property type="protein sequence ID" value="SEG83873"/>
        <property type="gene ID" value="SAMN04489712_11688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="765" mass="80327" checksum="8923AF46095EE3F1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGL3</accession>
    <name>A0A1H6DGL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84627">
        <property type="protein sequence ID" value="SEG84627"/>
        <property type="gene ID" value="SAMN04489712_11737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="182" mass="19925" checksum="F674ABBCF944A46A" modified="2017-01-18" version="1">MVRDAVDLIVEQWARARPDLDASPMRVLGRLSRVTRIAERELKALFQEFGLERGEFDVLATLRRAGSPEGMTAGMLARSSMVTSGAVTNRLDRLVAKGYVTRDVDPANRRTVIVALTPAGRELIDRAVAAHLDNERRILAALDRHQQDDLVAILRALLLSLGDKANDEASGEVGDGAAREED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJ43</accession>
    <name>A0A1H6DJ43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84636">
        <property type="protein sequence ID" value="SEG84636"/>
        <property type="gene ID" value="SAMN04489712_11739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG84636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="28618" checksum="798E4C3E13827207" modified="2017-01-18" version="1">MVANLCVVALPINFQMMTEIRHDPVAPTRTQHLPSGAMIDAHRHDDHQIIYAGRGVLAITTSAGSWVTPGTNAIWVPAGTVHAHQAHGDLDLHLVGLPTTDNPLGLDAPTVLGVSPLLRELIIAYTRNPDEDGGAERARMRAVLLDQLRASPRQPVHLPTPTAPLLRAVCGILQENPADGRTLVELGRQVGASGRTLSRLFRNDLGMTFPQWRTQLRLQHALVLLADKQPVTAVAHRCGWASASAFIDAFRRTFGHTPGTHPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKU8</accession>
    <name>A0A1H6DKU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sensory transduction regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85804">
        <property type="protein sequence ID" value="SEG85804"/>
        <property type="gene ID" value="SAMN04489712_11883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="161" mass="18473" checksum="DD20198F4028CA22" modified="2017-01-18" version="1">MSPVEVIEQALKDAELEYERPREGAFFVKLPGEHKLATMTWLIVGDHSLHVEAFFCRQPDENHTEFYRWLLEKNGRMYGVAFTLDPAGDVYLVGRVSLASVTAEEIDRLLGCVLSYSDDNFDKALELGFKTSIRKEWAWRVKRGESLANLRAFARFADPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKW3</accession>
    <name>A0A1H6DKW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component system, OmpR family, sensor histidine kinase SenX3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85789">
        <property type="protein sequence ID" value="SEG85789"/>
        <property type="gene ID" value="SAMN04489712_11880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="159"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG85789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="404" mass="43463" checksum="7A24387E7B363D6D" modified="2017-01-18" version="1">MEIVAALTGLAGLAIGLTAGLAVRVSERAQRAERPTAPGSVLPPGVASVLSVLRSSAVVLDREDRVLRASSAARAFGLVSGDRLVVDELLVMARLVRRDGEIRETEIQVRPSRSRARVEGRWFAVRVAPLGTHGLVLVLAEDLTEMRRVEAIRRDFVANVSHELKTPVGALALLAETVAGAADDPDAVRRFTGRMQHESVRLTNLVQDLMTLSRVQGDEPLDALRRVAVDDIIAEAVDRCQIKAEAKDIELVCGGLSGLRVRGDEELLTTALRNLIDNAVAYSPEHTKVAIGTRQADPDHVEVTVTDQGIGIPEVELERIFERFYRVDPARSRQTGGTGLGLAIVKHVTTKHGGEVVVWSKEGSGSTFTLRLPLLRGDGHSTQPPTAPRTSAGSAMDNAREATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKZ3</accession>
    <name>A0A1H6DKZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_118127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86000">
        <property type="protein sequence ID" value="SEG86000"/>
        <property type="gene ID" value="SAMN04489712_118127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045999">
        <property type="entry name" value="DUF5955"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19380">
        <property type="entry name" value="DUF5955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="118" mass="12583" checksum="CB2588CDA22BC94D" modified="2017-01-18" version="1">MTGDDHRVQIGGNARISGSQIASGQNVDQTQHLSGAQDGSPVEQAIDRVAELLERHSAELPDVHRAHRDLDDIRQEVSENDPDPDRIAHALDRLAARVAGIAAIAAAVRELASLLTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLN9</accession>
    <name>A0A1H6DLN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85626">
        <property type="protein sequence ID" value="SEG85626"/>
        <property type="gene ID" value="SAMN04489712_11848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="17562" checksum="278C4D38EEBAAC3A" modified="2017-01-18" version="1">MTMPDDADRLIDQWSRFLAALEADCPVCAGTGVVLSDAWQAWHERAGELSRVALAARRASGMRLDGNGAMVRVPDELPRRREPAEGHPGADAPTVMAAVERAIDEHERARPAEAEHVPCRACAGCGLVLTPIGRRLAQLLHRHGFVTVPDATPPPAAPGTNGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DM50</accession>
    <name>A0A1H6DM50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86284">
        <property type="protein sequence ID" value="SEG86284"/>
        <property type="gene ID" value="SAMN04489712_11942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="427"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="520" mass="56021" checksum="02BAE4BA97B610A5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMW5</accession>
    <name>A0A1H6DMW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MLTR_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_119140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86660">
        <property type="protein sequence ID" value="SEG86660"/>
        <property type="gene ID" value="SAMN04489712_119140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="2">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="157" mass="17715" checksum="5A295B3BC4AEC897" modified="2017-01-18" version="1" fragment="single">GAIPNHARFTFLDPRSHRFWGDWERAANDTVALLQAEAGRDPYDKDLTDLVGELCTRSEDFRTRWARHDVRQHHLGAKPFHHPVVGDLHLTYESLDLPADDLTLVAYGTEPGSDSEDKLRLLASWAAEVALHHHTPQHDDQPHNTTPHTTGMPHDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNU0</accession>
    <name>A0A1H6DNU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YwqG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86949">
        <property type="protein sequence ID" value="SEG86949"/>
        <property type="gene ID" value="SAMN04489712_12039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="29990" checksum="40D0AF05E925DC7B" modified="2017-01-18" version="1">MDWIVTERQRLHSLFGVFLAPEVSAAIVPLARPALRLGGQGTAVRLGGPPLLPPAADWPRWAGRPLDFLAVVDFAELAAVLRQPGMPGKGRAAFYYASRTPRPWGSRPEERDGWRVFTGELVESEPPPGVTSAPARTLGAAPFLSLPAPQEPVLQQVESRYSGILTVYEQLYAAWLQHLWPDDPVHQIGGWPVIVQRPVAPEAQHASSGRDPDTVTPEEQETAAGEGDEWSPLLQLDSDDHLGWHWGDPGRVYFCNRRSAPLEDSWLILQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP72</accession>
    <name>A0A1H6DP72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_119112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86563">
        <property type="protein sequence ID" value="SEG86563"/>
        <property type="gene ID" value="SAMN04489712_119112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="118" mass="13178" checksum="8189833D8D9E5FF6" modified="2017-01-18" version="1">MTDNALLLADAAAWRAWLAEHHETARDVWLMIAKKNGNATTVTIDEALDEALCHGWIDSHRRAFDGDYYLQRYSPRTRRSPWSSINVAKAEALTAAGRMRPAGRAAIETAKTTGRWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP80</accession>
    <name>A0A1H6DP80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiL</name>
        <name evidence="3" type="ORF">SAMN04489712_12081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87167">
        <property type="protein sequence ID" value="SEG87167"/>
        <property type="gene ID" value="SAMN04489712_12081"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="32325" checksum="FBB84329EF4E0820" modified="2017-01-18" version="1">MDERVPTTIGELGEFALIERLTARLPQGPAVRLGPGDDAAVIAAPDGRVVATSDLLVEGRHFRRDWSGPYEIGRKAAAQNLADVAAMGARPTALLLGLAAPPETEVAWVLRLADGLREECAPAGASVAGGDVVRAPQITLAVTALGDLAGGPPLTRAGARPGDVVAVRGRLGFAAAGLRLLAEGRDGPAELLDAHRRPRPPYEAGPQARELGATALVDVSDGLVQDLGHIAVASGTRIELDGDALPVPPVLGPAGLHHVLTGGDDHAFAGTFPPDVRLPGTWTVIGRVAEAAPGTGDVVVDGRPYTAGGWDHFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPH2</accession>
    <name>A0A1H6DPH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cold shock protein, CspA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_120100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87267">
        <property type="protein sequence ID" value="SEG87267"/>
        <property type="gene ID" value="SAMN04489712_120100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7011" checksum="DED4F4077923FFF1" modified="2017-01-18" version="1">MQGTVGTYDTATRTGTVLLDDGTELAFDAEAFAAGGLRLLRLGQRVNLAVEGGRITVVTLSTFPLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU26</accession>
    <name>A0A1H6DU26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase (PhyH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88857">
        <property type="protein sequence ID" value="SEG88857"/>
        <property type="gene ID" value="SAMN04489712_12294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="247" mass="26635" checksum="543B23147FA0C79D" modified="2017-01-18" version="1">MSRERWRSYLSAVDSFIRDGFIKVPAVVPREVADEARARLWERIEPVPDDPSTWTQPVVWTADLTGEGPFGQIITSKVLAQALDAVAGPEGWVPGGALGNIPVRFPHAEASNDDGWHIDASVPLQDGRWAVSVRPHTLLLLVLLSDVGPEDAPTRIRVGSHHDLPQVLSEEPMDPFAAGPLVDTATSGRPLAYATGEPGDAYICHPFLVHAAQRNLTGRPRFMAQVPIFLAEPLGPGGPPALATVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVG5</accession>
    <name>A0A1H6DVG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted thiol-disulfide oxidoreductase YuxK, DCC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89199">
        <property type="protein sequence ID" value="SEG89199"/>
        <property type="gene ID" value="SAMN04489712_12340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14470" checksum="F4DDD8CFD0AF8C4A" modified="2017-01-18" version="1">MTAGGRPVLVYDGDCAFCTGCVRFVERRVPTGARLVPFQFTDLDALGIAPERAAREIVWVDCDGRRYGGAQAVARLLMDAGGPWWPLGALIRIPPLRWAAHGVYRLVAANRHRLPGGTAACALPPAERPGAAPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVR4</accession>
    <name>A0A1H6DVR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88843">
        <property type="protein sequence ID" value="SEG88843"/>
        <property type="gene ID" value="SAMN04489712_12291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="588" mass="63933" checksum="442A704B4D44BC2F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVY6</accession>
    <name>A0A1H6DVY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxS</name>
        <name evidence="7" type="ORF">SAMN04489712_12349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89244">
        <property type="protein sequence ID" value="SEG89244"/>
        <property type="gene ID" value="SAMN04489712_12349"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="6">
        <location>
            <begin position="21"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG89244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="32311" checksum="CB304984390D9CAC" modified="2017-01-18" version="1">MSTASSAPVESAQPAPATGTARVKRGMAEMLKGGVIMDVVTPEQAKIAEDAGAVAVMALERVPADIRAEGGVSRMSDPDMIEGIIEAVSIPVMAKARIGHFVEAQVLQSLGVDYIDESEVLTPADYANHIDKWAFTVPFVCGATNLGEALRRITEGAAMIRSKGEAGTGDVSNATTHMRQLRAEIKRLSALPADELYVAAKELQAPYELVKEVAQTGKLPVVLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSGNPAQRAEAIVKATTFYDDPDVIAKVSRGLGEAMVGINVGTLADRDRLATRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWT3</accession>
    <name>A0A1H6DWT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89659">
        <property type="protein sequence ID" value="SEG89659"/>
        <property type="gene ID" value="SAMN04489712_12419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="404" mass="42839" checksum="32438811A2C3CCA3" modified="2017-01-18" version="1">MSDVKDVMRQLAEARPGHLDPGAPVEPHTRNAELPRIMAAARPSRAPGKARRPMWGLGLVGLAAAVLAVAMAVTGTDGPAPRSSGGGTAAPAVRGGTSAPAVREVTINARTALLAAAHGAQRQPQRTGRYWHVRTLFGTLEQVGPAGGRYAVLHRYQHDAWNPRSPDEEGWFRSEELGARPATTADEAAWRADGSPTAWVTGPKPKAGGGKPPNTRVPDLEMNPKDSAFAHSTGRASDAPDELNVTQDELERAAADPAELRALLLAHPLGEAHDGENTDAELFETAAGILMTKPLPPAKRAAIYRLLAGIDGVTATDGVKDAAGRTGTALKMRQRYPNGSVEIHFIVDRATGAGLAKEIHYLKGEGDRAWMKPGTRWYYEVVTSQWVDVLPDMPRGPRTGGGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXX5</accession>
    <name>A0A1H6DXX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Eco29kI restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90200">
        <property type="protein sequence ID" value="SEG90200"/>
        <property type="gene ID" value="SAMN04489712_12567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018575">
        <property type="entry name" value="Restrct_endonuc_II_Eco29kI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09517">
        <property type="entry name" value="RE_Eco29kI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="23439" checksum="908A89AD4FB324C3" modified="2017-01-18" version="1">MPPYTPEYYDPMSTDHITSMICLNLEDQPVTPLWPEIPRFDGSGLYAIYYIGSSIELYAPLSSYKIPVYVGQARSHNSATGKGVRERDPLWRRIRDHSKSIEGAGLPLHEFGVRLLRLPDVHIDLGENGLRVNYQPVWNAVLTGFGSHEQGSSTRQSSRSKWDTVHEGRNRTFGATKHDKDVLLAKARKHIDQQIADYSQVPWHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ90</accession>
    <name>A0A1H6DZ90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90670">
        <property type="protein sequence ID" value="SEG90670"/>
        <property type="gene ID" value="SAMN04489712_1274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="18062" checksum="778DB8B3AE5E7B11" modified="2017-01-18" version="1">MRIEVVGYDHPDAARLIGEAQQEMVVRYGGPDETPVAPSEFTPPSGLFLVGYVDGVPVVCGGWRSHGQDAELKRMYVAPAARGNGYARSLLAEIERTARAAGHRRVILETGTQQPEAVALYRSAGYTDVPAFGYYSCSPNSIHLGKLLDVPASAPGVPGGPEGVAATPDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E147</accession>
    <name>A0A1H6E147_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfonate transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91141">
        <property type="protein sequence ID" value="SEG91141"/>
        <property type="gene ID" value="SAMN04489712_12846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="23"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="26984" checksum="D83B661868477893" modified="2017-01-18" version="1">MTPVSGSEAGASASVTSLPEPVVRVSGLVKRFGDRAVLDGLDLEIRRGEFVALLGRSGSGKSTLLRALAGLEPVSGGELDVRGTVSVAFQEPRLVPWKRVAANVALGLDDPDPIVAAAAALTEVGLLGHRDAWPLTLSGGEAQRVSLARALVRKPGLLLLDEPFSALDALTRITVHRLVLDLWARHRPGVLLVTHDVDEALLLADRVLVLEDGRIAHQSTVGLDRPRHRDHPELIELRTVLLDRLGVTVEGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E326</accession>
    <name>A0A1H6E326_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91761">
        <property type="protein sequence ID" value="SEG91761"/>
        <property type="gene ID" value="SAMN04489712_13043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="27741" checksum="C449D810D04AE074" modified="2017-01-18" version="1">MAENTEVLSVYVACLRQIWARHGAPGAEEIASRTQGQIFPMSAPQVEAYLQGEAIPESSMELHVLLYGITDGYGRAWSKGPEEPESEVMTALRLWREVTDTPKGPDTTPLPVVPDRIDPSPPDIAPLPPDFAASPQDIMEVAIEVATYLGAAGIGGIIGNRTDSVVVRAASRLFQSVRDRWQSRGADTDGPLSEEEAVDAAIAAALAHDYRLESLRVASTEQRSDGSWRVSLTAPHLTLRVLVPAGDPADATILIIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3Z9</accession>
    <name>A0A1H6E3Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress response protein SCP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92380">
        <property type="protein sequence ID" value="SEG92380"/>
        <property type="gene ID" value="SAMN04489712_13334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="537" mass="54906" checksum="5A35CDDF8016BB06" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4N2</accession>
    <name>A0A1H6E4N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CubicO group peptidase, beta-lactamase class C family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92728">
        <property type="protein sequence ID" value="SEG92728"/>
        <property type="gene ID" value="SAMN04489712_13513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="386" mass="41762" checksum="0E81D774511D264A" modified="2017-01-18" version="1">MSAVPAQDPRVVKALDRARELGEEGLQVAAYLGGDLIVDAWAGSADPQAGRQVDGSTLFNVFSVTKAITATALHILAERGLVDYRAPVCRYWPGFARNGKESITVRDVLSHRAGIPWMPEDVTPERQADWDWMIRAIEDMPPAFEPGRTNSYHALIWGWIVGEIARRADPEHRPVEVLIRQEIVEPLGISDLFLGLPESEDGRVARLIGGDPAPDASETYLRGMPRQVFPGSTIYNTDLARRTVNPGAGAIGNARAFARFFAMLAGHGELDGVRLLPADVVDGFTEPREDADVTDLYLGGIAHVSAFGYWLGGSSPTANPAVGPNPRILHHPGAGGSISWAELDTGLAVSICHNRMHEGPFEPSAHPFVPIAEAVRAIAAERLERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E515</accession>
    <name>A0A1H6E515_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_13316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92323">
        <property type="protein sequence ID" value="SEG92323"/>
        <property type="gene ID" value="SAMN04489712_13316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="232"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG92323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="430" mass="45025" checksum="17B72DDF46EDBE3D" modified="2017-01-18" version="1">MTSEQVSKPSKVMTPGRWRRLAIDTRPLGHAAYRRLWLGQAVSFLGFQVTAVAVPVQVYDMTGSSFWVGVLGLVNLVPLIVFGLWGGAVADHVDRRRLLLAASCVTWVATLLLLAQALLGVHNLALIMATVAVHASGFAVASPTRGAIIPRLVDKERVAAANTLNFTASQIGMLAGPLAAGYILAHWNYSAAYALDAVLFTVGLYAALRLPPIPPLGERTGSPGLRSVAEGLRYLATQPVLLMSFVVDIIAMGVAMPRALFPELAETRFGGAEAVGWLFAAISIGSMLGGLLSGWIERVHRQGLALVAAIFVWGVAVAAAGLAHSLWLAVLLLAVGGAADLISAVFRQTMLQTYAPDEMRGRMQGVFVVVVAGGPRLGDLRAGATAAMTGATVSWVGGGVACAVLVVVVSLCVPALLRYDTRSARPPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E780</accession>
    <name>A0A1H6E780_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_13920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93517">
        <property type="protein sequence ID" value="SEG93517"/>
        <property type="gene ID" value="SAMN04489712_13920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG93517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="297" mass="31026" checksum="4041942E42F566C9" modified="2017-01-18" version="1">MALFLQRLIDGIGNGMLYGAVALALVLIYRATGMVNFAQGEMAMFCTFITWKLADHEFGLGLPIVAGIAGGVIFGFLFGAALERVVIRPFESADHLRQMIVTLGLFLAINALAAWIFTADTQRLASPFPSGALRLGGVSVSYHQLGVIAVLLVMALALRELFGRTRLGLAIRGASMNPESSRLLGVDVSRMLMIGWGLSAAIGALAGALVAPAVFVSPGMMQTLLLYGFAAAVLGGFDSAPGALVGGVMVGVVQAMVSGYVPAVGTQLQLATAFALILMVLLVRPQGLFGRVSVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAF1</accession>
    <name>A0A1H6EAF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94682">
        <property type="protein sequence ID" value="SEG94682"/>
        <property type="gene ID" value="SAMN04489712_1505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296686" evidence="1">
        <location>
            <begin position="32"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="39"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="369" mass="40273" checksum="E198841F8D78F47D" modified="2017-01-18" version="1">MSRITRVLAGGLAVAAVAGFCTTVAGGVAPAAADRAGRPVVIGHRGASGLRPEHTLASYRMAISQGADYIEPDIVATKDRRLVARHDNWLADSTDVENRSEFADRRKTKTVDGTTRTDWFTEDFTLAELRTLRTEERIPAVRPDNTVFDGLEPIPTLEEVLELARKHDVGVYPETKHPTYFDGLGLSMEEPLVATLHRYGFDSRGDKVFIQSFETANLRDLRHLTKVRLVQLIDGSGAPYDLVKSGDRRTYADLVKPEGLKWIASYAQGVGPATNRIVPVTADGRLGTPTTLVRDAHRRGLTVHTWTVRNENEFLPADFRQGNAAAPGYRSATGDVGGWLSKLYKLGVDGVFCDDPSAGVGARTEVFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBP0</accession>
    <name>A0A1H6EBP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94691">
        <property type="protein sequence ID" value="SEG94691"/>
        <property type="gene ID" value="SAMN04489712_1509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="466" mass="50951" checksum="090FDD936E6044B2" modified="2017-01-18" version="1">MPHAALTPVAVRDMATKLARHDFRHWAARTRALGGCAQPVHLRGRVEHLDPLTGEVLHRYTTSREPGGTLRVACKTRRASRCPACAETYRADTYHLVRAGLVGGKGVPDSVTAHPAAFVTLTAPSFGPVHTRREKPGGVQPCHPRRDAERCPHGRRLSCTLRHGAEDPRLGEPLCPDCYDHTGSVLFNALAPELWRRFTLALRRRLAKAAGLTVTALGDALTVSFAKVAEYQRRGVVHFHAVIRLDGPGGPAAEPPAWATHDLLAEAVRQAARAVTVTTPEAPGVPARSLAWGTQLDIRPITTTGELTDKAVAGYIAKYATKAAECVGTLDRRIRATDDPNDLPVSNHARRLIGECLRLGTLEEMAELRLAEWAHMLGFRGHFSTKSRHYSTTLGQLRTDRIHHNQRAREITTGRLPFTDEDQVLVIAHWRYVGQGLTPGEVLLTAALTGTPLPPLHPSADERTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S0L9</accession>
    <name>A0A1H5S0L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44152">
        <property type="protein sequence ID" value="SEF44152"/>
        <property type="gene ID" value="SAMN04489712_10132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF44152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="40" mass="4616" checksum="F6783AC1C444BBEA" modified="2017-01-18" version="1">MWKLPVRESNWTYDMDSHKMWNGVLKSPPVGDGTLDVVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S5P1</accession>
    <name>A0A1H5S5P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45127">
        <property type="protein sequence ID" value="SEF45127"/>
        <property type="gene ID" value="SAMN04489712_10164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="15"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF45127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="333" mass="36767" checksum="B91046507E1D9588" modified="2017-01-18" version="1">MEFRHLGRSGLIISEIAYGNWLTHGSQVEEDAAVACVHAALDEGVTTFDTADVYAGTRAEEVMGRALKGQRREGLEIFTKVYWPTGPGKNDRGLSRKHIMESIEGSLRRLQTDYVDLYQAHRFDHETPLEETLRAFDDLVRQGKVLYVGVSEWRAEEIERALKIADEMGFDRIISSQPQYSMLWRVIEEEVVPLCEREGIGQIVWSPIAQGVLTGKYQPGQPPPPGSRATDQAGGAGFIKSMLTDDILTRVQNLRPIADELGLTMAQLAVAWVLQNPNVSAAIVGASRPEQVRDNVKAAGVKLDAEVLKRIDDVLGPVVVRDPAETGSPSKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S6R3</accession>
    <name>A0A1H5S6R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol alpha-1,6-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46110">
        <property type="protein sequence ID" value="SEF46110"/>
        <property type="gene ID" value="SAMN04489712_10195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="186"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF46110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="374" mass="39563" checksum="B9A05B3B5FE99996" modified="2017-01-18" version="1">MTKTLVVTNDFPPRPGGIQAFVHNLALRRPPGSVVVYAPAWKGAAAFDAAQPFPVVRHPTSLMLPEPAVLRRAGRIARSEGCDSVVFGAAAPLGLLAPALRRYGVERLVGITHGHEAGWAALPVARRLLRRIGDGVDVLTYLGEYTRARMAAVLSPQAAARMARLAPGVDEQAFCAGAGGAEVRRRHGLGDRPVAVCVSRLVPRKGQDALIHAWPAVLREVPDAVLLLVGGGPYRAELERLAADRGVSGSVVFTGSVPWEELPAHYDAGDVFAMPCRTRRRGLDVEGLGIVYLEASSTGLPVVAGDSGGAPDAVLDGETGVVVRGRSVPAVAEAVAGLLGDPERARKMGEQGRAWVEREWRWDVQAGRLDALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S8L4</accession>
    <name>A0A1H5S8L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46949">
        <property type="protein sequence ID" value="SEF46949"/>
        <property type="gene ID" value="SAMN04489712_101117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045975">
        <property type="entry name" value="DUF5931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19354">
        <property type="entry name" value="DUF5931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5931" evidence="5">
        <location>
            <begin position="16"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="4">
        <location>
            <begin position="200"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="345"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF46949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="45159" checksum="838EF03BE6413278" modified="2017-01-18" version="1">MSRAGSRRAAPDPLGFEVPLWRAIAVFRAVALGYAGALILSNADEYRSRAGGWAVLAVMALWTAYASYAYAEPARRRLPLLAADLAVAAGCLLATAWVERPERIAEGAPTLPLAWVAASVLAWGVSGGKRLGLLAATLIGIAGITVHGVSGRGFVPSHATFNGVVLVLMAGFVAGHVARLGAKAEARLARAVELEAATRERERLARDIHDSVLQVLTLVQRRAERMRGELSDLSRRAAESQAAPGSAERPDRDRDPAPQVLALVRRRGEELGGEAAELGRLAGEQEAALRALIGLTPEAAESGGGTDLDLRALLAARSSTTVTVSTPATPVRLPAPAAREIDAAVGAALDNVRRHCDPGARAWVLLEDGPGEVTVSVRDDGPGMPAGRLAEAAAGGRLGIAQSIKGRIRDLGGRVSVISAPGEGTEIEMTVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S8N4</accession>
    <name>A0A1H5S8N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46979">
        <property type="protein sequence ID" value="SEF46979"/>
        <property type="gene ID" value="SAMN04489712_101118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF46979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="20532" checksum="C599A585B86F657A" modified="2017-01-18" version="1">MPDEDDKRVAGPDSGEPRQGPPAGPPQPPPAAPAPSAGPASAAPGPAGQPHPPGQASPAAPPPQPGQAPPGAPAPEQPAAAFHAPPPPPGGGKWRGQAREWGRSRPLQLLAAGVAGAIIGGGAVGLLDLLDDRGDEHHVRMIDRGGPYGPYGPYGPGWRRWGPEQDEDWRGRMPPEWRLPRRLPPTEPPTAPAPSPTPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJU1</accession>
    <name>A0A1H5SJU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="11" type="ORF">SAMN04489712_101237</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50710">
        <property type="protein sequence ID" value="SEF50710"/>
        <property type="gene ID" value="SAMN04489712_101237"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="320"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF50710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="41424" checksum="44311E0CFBB63C0C" modified="2017-01-18" version="1">MLRWLTAGESHGPALVAIVEGLPAGVRVTSGDIAEALRRRRLGHGRGARMKFEQDQVTIVGGIRHGRTQGGPVAVEVGNTEWPKWETVMSADPVDPQVLAEQGRGPGGRNAPLTRPRPGHADLAGMQKYGFGDARPVLERASARETAARVALGEVAKAFLRQSLGVEVLSHVVGLGEVSAPAGLQPAPADLPAIDEDPVRCFDAETSAEMVAHIDELRKAGDTIGGVVEVLAYGLPPGLGSHVHWDRRLDSRLAGALMGIQAIKGVEVGDGFETARRPGSKAHDEIEGGAGGLRRRTNRAGGVEGGMTTGDVLRVRAAMKPISTVPRALDTVDVATGEPAKAINQRSDVTAVPAAGVVAEAMVALVLADAVLEKFGGDSVEETARNAQGYLSSLTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SKJ0</accession>
    <name>A0A1H5SKJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, DUF58 family, contains vWF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51106">
        <property type="protein sequence ID" value="SEF51106"/>
        <property type="gene ID" value="SAMN04489712_101253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="202"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF51106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="422" mass="44457" checksum="E79D4B6B4696D528" modified="2017-01-18" version="1">MKRTLGGLTTRGRSFVAAGVTAIVCAFALGERDLLRAGVLVLALPLLSSLVVSRTRYRLACARRLDPPRLSVGHEARVDLRLENVSRLPGGLLLVEDRVPYTLGGRARFVLDRIEPHGSRELSYRVRSDVRGRYQVGPLTVRLADPFGLVELVRSFSLADRLTVTPPLVELPPGRLMGGWTGGGDSLARTVANAGEDDVAPREYRHGDDLRRVHWRATARRGELMVRREERHWQSSGTLFLDTRRHAYAGEGPAGSFEQAVSIAASLGVHLSRAGMGLRFVTDAGQVLSPSAAFEGALLDALAVVHPSTVRSLTPGLAAMGGAAGPGREGEGLVIAVFGVLDAQEAQALAAARRGTSTYVAILVDPRADPAAGGGAGGGTGRTARLLRAAGWRVAVVGSAAGLAAAWTAADQAAEESARGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SNQ6</accession>
    <name>A0A1H5SNQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52084">
        <property type="protein sequence ID" value="SEF52084"/>
        <property type="gene ID" value="SAMN04489712_101291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF52084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="8632" checksum="3D019A6223DCF8A6" modified="2017-01-18" version="1">MATERINVSLPETQLRMLDAHVKRVGVSRSLFIGESVRKALLHDALTQLGGAGVLGDEDWLNTIETDRDPDFWGAAAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SWR0</accession>
    <name>A0A1H5SWR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54996">
        <property type="protein sequence ID" value="SEF54996"/>
        <property type="gene ID" value="SAMN04489712_101395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF54996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="146" mass="16292" checksum="67B94537134EF2AF" modified="2017-01-18" version="1">MITGVGVTTVWVLDQDRAKEFFVGKLGMELRDDVTMGEGGMRWLTVGAKDQPDLMLTLMVPGPPAQDPESAEQLKALLAKGVLGAAVFTTTDCEGDYRELKERGVTFLQEPQRRPYGVEAIFRDDFGNWYSLTQRFAEPDESTAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SYP1</accession>
    <name>A0A1H5SYP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55615">
        <property type="protein sequence ID" value="SEF55615"/>
        <property type="gene ID" value="SAMN04489712_101413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="724"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF55615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="768" mass="78344" checksum="E7D6EA6F901584C3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T351</accession>
    <name>A0A1H5T351_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56511">
        <property type="protein sequence ID" value="SEF56511"/>
        <property type="gene ID" value="SAMN04489712_101441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF56511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="9858" checksum="D1C516574115E827" modified="2017-01-18" version="1">MSTAAGCPAGGRAPTLRDMNAHFSSGRAAAAFAGLLAGGAAGFLLIEIVGAFFTIVLDRSLALDGTGEPSLAVLAVPVICAVAGAVVGARLAGRGPHSGNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TB88</accession>
    <name>A0A1H5TB88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59331">
        <property type="protein sequence ID" value="SEF59331"/>
        <property type="gene ID" value="SAMN04489712_101532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="41"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF59331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="36465" checksum="A160130C24367BEF" modified="2017-01-18" version="1">MDPIGEKLLDIAKTELGYREKSGGYTKYGDWYGKNVDNNSYFKNAPWCDMFLAWAADKAGVADWAGQFAYTPFHAKWFREEGAWGTKPKPGAIIFFDWSGSKSLDAIDHVGIVEKVEGKTIHTIEGNVDGVHLKRKERTAGTIVGYGYPAKVVVPGRTVESVTSGATRDTEQGTGQEHVPGHAAPGSSTDRGAPADHGMPGTATRDVGPRGQDVSSDQPISALDVLTIVILGSVALAVGKAVLTRVPAGLPASSPVRFRKRGRHHRTPVALPVGVTPADLAAADSSTAPMRAVTAAVAAEAEDREFWSQVSHLREDDDLAYWGSMAENGEKAEKAEEGAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TB91</accession>
    <name>A0A1H5TB91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60073">
        <property type="protein sequence ID" value="SEF60073"/>
        <property type="gene ID" value="SAMN04489712_101553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF60073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="37004" checksum="A75F0DDD59F7BB34" modified="2017-01-18" version="1">MSTHAPVARVNGLVKDFRIPGGRVLRAVDGVSFEVGRGETLGLVGESGSGKSTVARMLIRLDRPTAGSVEFEGADITALRGAALRRQVRRRMAMVFQSSSTSLNPYQRVGEVLAEPLRVHRVGEAGARGRAVETMMERVGLDPAFAGRYPRELSGGQRQRVGIARALMLDPSLIVADEPTASLDVSVQAQVVNLLQDLQRDLGLSYLFITHDLGLVRHLSHRVAVMYLGRLVEVGDTAQVFAEPAHPYAAMLVSMRRQAEHRILPAGEIPSPIDRPSGCVFRSRCPIAQARCERDVPPLVEIAPGRRAACHFPGELRPGGTDAPVHVPAAPPLVAPLTSQKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TBV6</accession>
    <name>A0A1H5TBV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crotonobetainyl-CoA:carnitine CoA-transferase CaiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60276">
        <property type="protein sequence ID" value="SEF60276"/>
        <property type="gene ID" value="SAMN04489712_101559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF60276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="405" mass="43678" checksum="6D87D79CC08686C1" modified="2017-01-18" version="1">MSGPNVMDGPLRGLRVIDVSTILAGPLCAQILGDFGAEVLKIEHPTAGDGMRGHGRSKDGHSLWWKEISRNKRTLGLSLSDPAGAAILLRLAETADVLVENFRPGTLERWGLGPDRLHEVNPGLVIVRVTGFGQRGPYAGRAGFGTLAEAMSGFAHLTGDADGPPTLPAFGLADSVCGIAASAAAMMALFHRERSPDRRGQVIDMSLLEPLMTAVGTAPTVYDQLGIVETRHGNRSTNNAPRNTYRTADGHWVAVSTSAQAIAERVMRLVGHPEVIDEPWFATGRGRVEHVEELDKMVGEWIGARDREQVLAAFTEAGAAIAPVYDARDIVNDPHIRQTEMITSVPDPDLGALLMHNVMWRMSRTPGRIRFTGRPLGADTDEVLVGELGLDPGEVRALRERRIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TWG9</accession>
    <name>A0A1H5TWG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67185">
        <property type="protein sequence ID" value="SEF67185"/>
        <property type="gene ID" value="SAMN04489712_101773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF67185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="13409" checksum="3360422766CD06D0" modified="2017-01-18" version="1">MATLALPKPVEDYLAAANAHDLDALIATFAPDALVNDARREFRGMRAIRRWLAEELIAAKVTKKIGDVREHYGEVVADVIIDGEFDRTGLPDPVVLTHYFTVRDGRIVRLIIILNESVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TYX7</accession>
    <name>A0A1H5TYX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
            <ecNumber evidence="6">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">araA</name>
        <name evidence="8" type="ORF">SAMN04489712_101802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the arabinose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68044">
        <property type="protein sequence ID" value="SEF68044"/>
        <property type="gene ID" value="SAMN04489712_101802"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arabinose_Iso_C" evidence="7">
        <location>
            <begin position="357"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF68044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="496" mass="53988" checksum="4E73E3FDA3C66578" modified="2017-01-18" version="1">MTDREVWFLTGSQGLYGEDTLRQVAGQSREIADRLAGHLPVRVKWVPVLTDAAAIRRVCLDATSDDSCIGLIAWMHTFSPAKMWITGLDALAKPLLHLHTQANVELPWSTIDMDFMNLNQAAHGDREFGHVQARIGVARKTVAGHVTDEHVTARALSWVRAALGAAELRTLRLARFGDNMRDVAVTEGDKVEAQLRFGVSVNTYGINDLVAVVDDVADAEIDELVKEYEARYSVVPELRAGGERHDSLRYGARIELGLRTFLSDGGFGAFTTNFEDLGGLRQLPGLAVQRLMADGYGFGGEGDWKTAALLRTLKAASADLDGGTSFMEDYTYHLTPGQQLILGAHMLEVCPSIAAARPSLEIHPLGIGGREDPVRLVFDAAPGPAHVVGLADMGDRFRLVANAIETVAPPEPLPRLPVARAVWRPLPDLATSAEAWITAGAPHHTVYTAALGAEELADFAEMVGVELLTIDADTELRQFTQELRWNQAYHRLAQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TZC1</accession>
    <name>A0A1H5TZC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68204">
        <property type="protein sequence ID" value="SEF68204"/>
        <property type="gene ID" value="SAMN04489712_101808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF68204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="41838" checksum="8C1DA7BBA974D9D4" modified="2017-01-18" version="1">MNNTGFDLFRISEDHEALRDAVRAVAQDKIAPHAAEVDEEATFPQAAHDALVASDFHAPHVPEEYGGVGADALATCIVIEEVARVCASSSLIPAVNKLGSLPLILAASEEVKARYLPPLARGEAAFSYGLSEREAGSDTASMTCRAVPDGDDWILSGHKAWITNAGVSKYYTVLAVTDPDGRRGANVSAFVVEKSDPGFGFGAPERKLGIKGSPTRELHFDNVRIPGDRMVGAPGEGLKIALRTLDHTRITIGAQAVGIAQGALDVALAYVRERKQFGRAIAEFQGLQFMLADMAMAVETARQMVYVAAAKSERGDKDLPFFGAAAKCHASDVAMRVTTDAVQALGGAGYTRDFPVERMMRDAKITQIYEGTNQIQRLVMARHILRGQTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U3L9</accession>
    <name>A0A1H5U3L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68831">
        <property type="protein sequence ID" value="SEF68831"/>
        <property type="gene ID" value="SAMN04489712_101830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="165"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF68831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="310" mass="33542" checksum="650E69D86BFB0EB0" modified="2017-01-18" version="1">MISGLRAATVSVADLERSCSFYQDVFAYTRLAEAKVAGREAELLWQMPSGLTGRTAVLGPEGAATGLLRLVEFDEPGEPYWGDYSRAQDYGHYALNIRVRDIHTAVARLRAAGGRSKSEPSHWTVAAGLSAWDSLSYDPDGNVLDVFQLEAAEGSLLADYDGRPSVLQTVAIHVSDARASADFYSALGYVELYDKLVENMESFFRLPPGTGLRNINLYAPDSPSAGRVELAQYVGFPGVQQRDRAVPPHRGILSVSLATDDLAATAALVTRLGGEPVCPAVELDLPPYGRTLAQSFFGPDGEVLEFHQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UVJ8</accession>
    <name>A0A1H5UVJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ORF">SAMN04489712_10249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79033">
        <property type="protein sequence ID" value="SEF79033"/>
        <property type="gene ID" value="SAMN04489712_10249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF79033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="502" mass="52717" checksum="F67909E6C3E950FF" modified="2017-01-18" version="1">MSGELTRRSAAELAELIASGQVSAVDVAQAHLDRIAAVDGEVRAFLHVDAETTLAQARAVDERRAAGERLGPLAGVPIAHKDVFTTADMPTTAGSRILQGWRPPYDATITARLRAAGLVIIGKTNMDEFAMGSSTENSAYGPTRNPWDTSRIPGGSSGGSSAAVAAYEAPLATGTDTGGSIRQPAAVTGIVGVKPTYGGSSRYGLIAFASSLDTPGPFARNVLDAALLHEAFSGHDPMDSTSIDRPVPPVVEAARRGDVAGLRVGVVRELGGEGYQPGVLARFNDSVELLESLGAKVVEVSCPHFGYALPAYYLIAPSECSSNLARFDAMRYGLRVGDDGTRSAEEVMALTRAEGFGPEVKRRIMLGTYALSSGYYDAYYGKAQQVRTLITRDFDAAFEQVDVLVSPTTPTTAFPIGDRVDDPMAMYLADLATIPANLAGNAAISVPCGLSDDGLPVGLQIMAPTLADDRVYRVGAAVERALEDRWGGPLLAKAPELAEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V0R3</accession>
    <name>A0A1H5V0R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80067">
        <property type="protein sequence ID" value="SEF80067"/>
        <property type="gene ID" value="SAMN04489712_10289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF80067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="28144" checksum="8D25472DBA2C18A0" modified="2017-01-18" version="1">MQDRPAYLRIAGELREQIRRGDYPPGSRLPTLARLCQTHGVSEIVVRQAVALLRGEGLVETRRGGGTVVRVRPAARRLAMSRYRNDPPAAAPATSFTRDQRIGWNEYRLDKTFTRVRADPHLASLFELPAGTELLRRRFVFHSRGEPQQISVSYLPWSLVEGTPVADPAREPWPGGTPAQLASLGRPVTRVEESVQARMPTPEEVETLRITAGVPVLTITRRMFSGDRPYEVCRDIVIPADRVTLDYSIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V9J6</accession>
    <name>A0A1H5V9J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83874">
        <property type="protein sequence ID" value="SEF83874"/>
        <property type="gene ID" value="SAMN04489712_102222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040611">
        <property type="entry name" value="TetR_C_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18556">
        <property type="entry name" value="TetR_C_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF83874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="199" mass="21707" checksum="C683A7366A228E3A" modified="2017-01-18" version="1">MEGLLSRRAGPEHDALDVRILDAALAEFETYGLRRVSVEDVARRARVARTTIYRRFSNKEQLLQAVILRECRRFLSGIAAATEGLPAREALVEGFVAGLREARSNPLLTRVVQSEPEAFLPQLSMNGGAVMLAARDILAERLGRDRPQGGEDLAAVCEILLRVALSLLLVPGGGLAVNDDEAARALARRHLIRLLPPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VCZ4</accession>
    <name>A0A1H5VCZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85222">
        <property type="protein sequence ID" value="SEF85222"/>
        <property type="gene ID" value="SAMN04489712_102271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF85222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="13103" checksum="468D29F01B4E1822" modified="2017-01-18" version="1">MEVLRIVLLIGHFAALAVLLGAFVGQLAAGRVFGAAMVGAAGALLGTGLLLVAVRAADDLSVNGPKIGVKLAIAAAVLGCALVGRRRTATAVAAPVPAGGAVPVSPPAGARSSAVGLFYAAGLLTIANVAVAVAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W4S2</accession>
    <name>A0A1H5W4S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinofuranan 3-O-arabinosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94410">
        <property type="protein sequence ID" value="SEF94410"/>
        <property type="gene ID" value="SAMN04489712_102586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021798">
        <property type="entry name" value="AftD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11847">
        <property type="entry name" value="DUF3367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1378"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF94410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1422" mass="150392" checksum="15A24ABA3EA10BA5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WBF5</accession>
    <name>A0A1H5WBF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96909">
        <property type="protein sequence ID" value="SEF96909"/>
        <property type="gene ID" value="SAMN04489712_102659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF96909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="24310" checksum="E1B57D4F6FF6DCC4" modified="2017-01-18" version="1">MIKVLIVDDQTIVRAGFAALLNAQPDITVVGEAGDGREAVRLAERAHPDVVVMDIRMPGMDGIEATRRILGRPGHDGLRVLVLTTFDVDEYVYDALSVGASGFLLKDATAEELVSAVRVVARGDSLLAPQVTGRLIREFTRQRRNRPQAPAELSTLTAREREVLILIAGGLSNGEIAEHLVLSEHTVKTHVARVFTKLSLRDRAQAVMLAYESGLVTPGGDRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X4M9</accession>
    <name>A0A1H5X4M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monosaccharide ABC transporter substrate-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06712">
        <property type="protein sequence ID" value="SEG06712"/>
        <property type="gene ID" value="SAMN04489712_10386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289064" evidence="1">
        <location>
            <begin position="38"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="61"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG06712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="34309" checksum="04B0DEC49F16DA27" modified="2017-01-18" version="1">MKPMKGAGPRPAVAMTATIMATALVLGGCSGSGGKKAEEEAASGAAPGAGPRLKVAMVTHSGPGDTFWDIVQKGARAAATKDNVELLYSADPDGGKQAQLVQTAIDQKVDGIIVTLAKPDAMRDVLAKATAAKIPVVSINSGAAESARLGALVHFGQDETVAGEAAGEQLKKIGATKAVCVVHEQGNVGLEDRCAGAKKTFGGPMENLFVQGTNMPQVKSSITAKLQTDSGIDGILTLGAPFAATAVDSVKETGSDAKVGTFDMNKELIASLRDGSIQFAVDQQPYLQGYLAVDELWLLKNNGNVVGGGRPVLTGPAIVTKDDAGTIAPFADRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X7V6</accession>
    <name>A0A1H5X7V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07565">
        <property type="protein sequence ID" value="SEG07565"/>
        <property type="gene ID" value="SAMN04489712_103118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG07565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="16788" checksum="6DEBE8BD5D3ECB86" modified="2017-01-18" version="1">MVDHGRQHFGAGPGGTGRGRPGGPERSGDPAWTGDPSAQAAPGDRRSLVRPYTVTGGRTRPRYDLAIEALVSAAPYPPRDVSTLTPEYRAIIDLCRSWRSVAEVSALLRLPLGVTRVLIADMAHEGLLRLHQSRPADAQPDIRLLERVLSGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X856</accession>
    <name>A0A1H5X856_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07921">
        <property type="protein sequence ID" value="SEG07921"/>
        <property type="gene ID" value="SAMN04489712_103134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG07921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="314" mass="33470" checksum="3326767E3A985AE9" modified="2017-01-18" version="1">MSRASHCDHCTGSHTGRRSCLATATTKARGWLLIEHPGPWPDKIERIDGPAPVVAAIARASRARVRPQLIRRPGRRRAVPPMRVYVGGSLDGRVWLEERVLADPAELDALDETALAGVAAGRQPGFGELVAGGGGPARPFGTPLLLVCTHGKRNVCCAQHGAPLARELAARFDGLVWETSHVGGDRYAANLVCLPHGLYYGNLDPAEAESAVRAYLRGEVALKRLRGRAGMPEPAQAAEHHVRALTGALGVDSVSVESLTGTSPYEAVIDVEGTRYRAVVEEAEPVHECEPGCQENVRSYVVSGITLLNEAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X9L2</accession>
    <name>A0A1H5X9L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08429">
        <property type="protein sequence ID" value="SEG08429"/>
        <property type="gene ID" value="SAMN04489712_103154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG08429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="489" mass="54650" checksum="D0AA23C4D018B4F2" modified="2017-01-18" version="1">MGRRDLSIAVVGAGFSGIGLAIGLKQAGFTDLTIFDKADGVGGVWRDNTYPGAACDAPSYLYSYSFEPKPDWTRRFAEQPEILDYLRHCTAAYGLTPHLRLGIEIIDAEFDAARGRWRVRTGDGEHLEYDLLVAACGQLSNPAVPRLPGMDSFGGTMFHSARWDHDHDLTGARVAVVGNGASAIQFVPLIASDAESLTVFQLEVHWISRKPDRVYPRWRHALNRRVPAVQKLSRLGIFLWFELVLNPSLVSPRGRRLLSAPVRALCRYALRSVRDPKLRDRLTPRYEPGCKRILTSSEYYETLNRPNVGVIDSPITELTPDGVRTADGEHHLADTVIWATGFRSQDFVAPMRVTGPHGTELNDAWKDGARAYLGLAVPGFPNFFLMYGPNTNVGSGSIVHMLESQIAYIVQAAHLLARGVTSMDVREDVLDRFDAAAQRRLSASVWNQGGCDSWYLDADRRNTNNWPGFMTGYRRRTRRLNPSDYHLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XD00</accession>
    <name>A0A1H5XD00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09622">
        <property type="protein sequence ID" value="SEG09622"/>
        <property type="gene ID" value="SAMN04489712_103199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG09622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="198" mass="21110" checksum="439A9A0A37B33B77" modified="2017-01-18" version="1">MTERRYGRHAKPPSRLRVRCDRLIDAALSERDRRKVIAIGTGSVSAVLLAVAGGAVLWLPGSGAGPSDGLAAQAAARQATPSPTVTVTTATGAGADPDQVPDAEAFFLTKDPGRKVAGHVEDVRRSGSFLRVYTDLREGDENSKPAISLCEWTAEFLREHVGEGEPIVFVHAKENDNGHVVLANKQSADDDCRVGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XEE2</accession>
    <name>A0A1H5XEE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10131">
        <property type="protein sequence ID" value="SEG10131"/>
        <property type="gene ID" value="SAMN04489712_103218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG10131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15636" checksum="2A60D028EAB7FC97" modified="2017-01-18" version="1">MQAISVRQPWAFAIARGGKTVYNHVLPTAYRGPLLIHASMRVDLGSCDSPLIRSAGWDPRDPLATLGAVIALAELADVCTAALHGERCGCGPWAEPARCHWRLAEVRALPRPIVALGRVDPWVPPPSLVTEVHAMLATAALRHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XM45</accession>
    <name>A0A1H5XM45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglycosylase SLT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12296">
        <property type="protein sequence ID" value="SEG12296"/>
        <property type="gene ID" value="SAMN04489712_103297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289630" evidence="1">
        <location>
            <begin position="43"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_2" evidence="2">
        <location>
            <begin position="300"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG12296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="386" mass="40771" checksum="7651165295D317EB" modified="2017-01-18" version="1">MAPARSRPAAVRPRARSGRGRRLAVAVLAAASAVTLAGGVFTALTFEDGRQRARAATGRSLPEPTGLPGPVANVVDTAQVAPLRRVVPPDVLVVGTSSITAAQARRVSRLRGVRDAALVSGGAVQLQSRLVNTFAVDPSAFRSWTPPATARDTRLWAALAAERFVVSQKAARELRLSTGVQYPIVAKSIPSVMLGGSGDLGLPGIDMLVGKRTGQELGLVPNIALLVNAPGADPAALTRAIEAIFRGGAKVVNLNERKYRQATNYLDLYRQAATGCRGLSWTVLAAIGQVESDHGRNTGPSSAGALGPMQFLPSTWKSYGVDGDRDGKADIMNPYDAIPAAAKYLCDHGGGRGGRSLYNAVYAYNHAHWYVQKVLDLARAYAARYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XRH0</accession>
    <name>A0A1H5XRH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13856">
        <property type="protein sequence ID" value="SEG13856"/>
        <property type="gene ID" value="SAMN04489712_103357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG13856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="49" mass="5084" checksum="25CE2039CB594BB1" modified="2017-01-18" version="1">MNRTSETGDEPVLTPPEPVAPIAPGRAATIIPDGEAIRTALDERDGGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XW42</accession>
    <name>A0A1H5XW42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15667">
        <property type="protein sequence ID" value="SEG15667"/>
        <property type="gene ID" value="SAMN04489712_103427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="11"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG15667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="70" mass="7689" checksum="EDCAF7CBD262CAC7" modified="2017-01-18" version="1">MVPSSRFGRLVWRKSSYSQGLDQNCVELARAGEAVGVRDSKDPDGPRLIFTAAELRSFAAALRAGRHRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YT63</accession>
    <name>A0A1H5YT63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27383">
        <property type="protein sequence ID" value="SEG27383"/>
        <property type="gene ID" value="SAMN04489712_104175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="636" mass="68305" checksum="482AFBCCC7883004" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z1L1</accession>
    <name>A0A1H5Z1L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acetylserine/cysteine efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29495">
        <property type="protein sequence ID" value="SEG29495"/>
        <property type="gene ID" value="SAMN04489712_104270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="143"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG29495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="312" mass="33303" checksum="02424A70252EF1DA" modified="2017-01-18" version="1">MRPRDVLLATLIAAIWGFNFVVIEVGLDSFPPLLFAALRFVAAAVPAVFFLRRPRVPVRWLWLVGLPLGVGQFGLLFLGMRMGMPAGLSSLVLQTQALFTIVFAGLLLRERLGRRQAAGMLVAFGGVALIGLDFGQGGPLPAFVLCVVGASMWGLANVAMRRMNQTAAEPVDALAFMVWMSLVPPLPLLALSLVFEGPAAGLRALTHLTLTGVGSLAYIAYLSTLVGFGLWGWLMRRYEAGTVAMYSLLVPPFGIVSAMLVLGERVGAVRWLAAVLVIGGVAAGSVRRSRPAPPPPAEHRPDGDRLSRVARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z2A7</accession>
    <name>A0A1H5Z2A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29765">
        <property type="protein sequence ID" value="SEG29765"/>
        <property type="gene ID" value="SAMN04489712_104281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="4">
        <location>
            <begin position="44"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG29765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="344" mass="36298" checksum="5D1BC3DD816B21D7" modified="2017-01-18" version="1">MSRVTRHDEATRREPATPGRHRGAPGPEPVTLADIEEAAARLSGVCLRTPLVPYPLADPPLLVKAESLQPVGAFKLRGAYNAIARLPEAERARGVVTHSSGNHAQAVAYTARRLGIPVVLVVPHTTPGVKVDACRRLGAEIVYVEPTMEARTATAGRLAEAHGFTLIPPFDDPAVIAGQGTVGLEIVQDAPDVGAVLVPVGGGGLISGVAAAVRALRPQAKVIGVEPELAADARASLRTGRRVAWTAEDTGRTIADALRAQRLGALTFAHIREYVDDIVTVREEEIREAMRRLARQVRLVAEPAGAVATAAYLFHRDELPSVSSYVAVLSGGNVDPALFAEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z4H8</accession>
    <name>A0A1H5Z4H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FtsK/SpoIIIE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31469">
        <property type="protein sequence ID" value="SEG31469"/>
        <property type="gene ID" value="SAMN04489712_104359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="1">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG31469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="105" mass="11241" checksum="A0323E69F704C63E" modified="2017-01-18" version="1">MRAPLTEVAVTPETGELLPVRPGRLENGSDWVIDFRTVPHWLNAGATQSGKSNMANAILKVLAPQPVALVGFGLKGGAEFTPYAPRLVRGLSMWCGGSRIRTWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z9Z9</accession>
    <name>A0A1H5Z9Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33122">
        <property type="protein sequence ID" value="SEG33122"/>
        <property type="gene ID" value="SAMN04489712_104441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG33122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="526" mass="52615" checksum="4E66B66E62B4461E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZDQ0</accession>
    <name>A0A1H5ZDQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-monoxide dehydrogenase medium subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34401">
        <property type="protein sequence ID" value="SEG34401"/>
        <property type="gene ID" value="SAMN04489712_104497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="30120" checksum="0B9506DAC846D43E" modified="2017-01-18" version="1">MIPAGFEYVRPESVDEAVSALAEAGEDAKVLAGGQSLMPLLRMRLAYPEVLVDLDRVAELREIRDLGDALFIGAMATHHQVMRDPLVRRHAPLIAQATATVADPATRHRGTFGGALAHADPAGDLPAVALALDAVCNVRSARGSRDVPAADFFVDWLTSALEPDELLTGVTVPKLGPGWGTHYEKFHRTAQSWAVVGVACAVRRERDAVADVRVALTNMGAAPVRATAVERSLEGVPVSDGAFRSAAEHAADGTAPPGDLHGSPDYRAHLAQVLTRRALTAASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZVI9</accession>
    <name>A0A1H5ZVI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Deferrochelatase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxidase EfeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22585"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="6">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40518">
        <property type="protein sequence ID" value="SEG40518"/>
        <property type="gene ID" value="SAMN04489712_10538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006313">
        <property type="entry name" value="EfeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01412">
        <property type="entry name" value="tat_substr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG40518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="411" mass="43707" checksum="588F4BEA49DEE9EA" modified="2017-01-18" version="1">MTAGPDTAGGGRVSRRRMLGLSGAGLLVGAAAGAGVDRALADHHETPGGAVPFHGAHQAGIATPVQDRLHFAAFDVVTEDRDRLVRLLKEWTAAAAAMTAGRPVGRGAVGGVAEAPPDDTGEALGLPPSRLTLTIGFGASLFAKDRFGLQDRRPPALVDLPHFPGDKLDPQRSDGDIAVQACADDPQVAVHAVRNLARIGFGVVSVRWSQLGFGKTSSTTPDAQTPRNLMGFKDGTANIPGTDDDLLAKHVWAAAADGADWMAGGSYLVARRIRMHIETWDRASLAEQEQIIGRDKKEGAPLGARREHDPVDLRRLAADAHVRLAHPDSNGGARILRRGYSFTDGSDGLGRLDAGLFFLAYQRDPRTGFIRIQRNLAGDSLNEYLQHVGSGLWACPPGVRRGGYWGDTLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZW2</accession>
    <name>A0A1H5ZZW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative zinc-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42063">
        <property type="protein sequence ID" value="SEG42063"/>
        <property type="gene ID" value="SAMN04489712_105115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG42063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="22915" checksum="DF0316C4E23D5E58" modified="2017-01-18" version="1">MTCLGERLTALVDGELDHDERDRALAHLAVCRACRQEADTMRRLKGRLRALASPPQDPAVAPDLPGDDFLNRLRALGEQRPGSGDASGPPVGGTGAWPPHPGARRVPPLRGPSPMPMRAAATRRRHARPFAGDGGVPVRVGAAAVPVRRRIPRRYLAVGAAAMVLGLGSASYALGGVTEQQPSVVPAFDRLEAEHALTNGIIPMTEMSPAPAPSAPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9F2</accession>
    <name>A0A1H6A9F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44992">
        <property type="protein sequence ID" value="SEG44992"/>
        <property type="gene ID" value="SAMN04489712_105281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="757"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG44992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1002" mass="105486" checksum="BC7B434528068C18" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9T3</accession>
    <name>A0A1H6A9T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45211">
        <property type="protein sequence ID" value="SEG45211"/>
        <property type="gene ID" value="SAMN04489712_105291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG45211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="60" mass="6093" checksum="0BE8C00AD0519157" modified="2017-01-18" version="1">MRVSAYTKFIVAALAAVGVALNLAIGDDTLTTSEIVDLVLVGLGALGVYALPNRPAGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ACI3</accession>
    <name>A0A1H6ACI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46010">
        <property type="protein sequence ID" value="SEG46010"/>
        <property type="gene ID" value="SAMN04489712_105337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG46010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="314" mass="32521" checksum="2322357A4779B215" modified="2017-01-18" version="1">MSPVFALAVDIGGTKLAAALVEPGGRIAHYDRMQTPVDLDAEGLWRSLEALLDKLLAEAGGGDLAGVGVGCGGPMRWPSAEVSPLNIPAWRDFPLRERLRARHPGLPVRVHNDAICMAVGEHWRGAGRGRDNVLGMVVSTGVGGGLILGGHLIDGASGNAGHIGHVVVDPEGPPCKCGGRGCLEAVARGPGLVAWAQEQGWRPDRAEVTGVELADDARRGHPVATAAMRRAGRALGVAIASATHLCDLEVVSVGGGLSQAGPLLFDPLEEAFRAHARMDFAREVRVVPAALGQTAGLIGAAALVFAADRYWSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AGY8</accession>
    <name>A0A1H6AGY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase family 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47265">
        <property type="protein sequence ID" value="SEG47265"/>
        <property type="gene ID" value="SAMN04489712_105411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH26" evidence="6">
        <location>
            <begin position="33"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG47265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="345" mass="38122" checksum="4C0C510A4C4CB104" modified="2017-01-18" version="1">MVLAAVLTLPGCDGGSKTPKIQTTVRPGVAPTPPTKGAYFGAWVDPARDGSGSPAPSGSPSASASPSKTASPSERARVDAVTGFERDMGRRLDIVAAYRSWKQRLPQDSDAELLSEGRYLLVTWSGTDTREIVAGEHDDHIRQQARAVKSLGKPVFLRWQSGMDADKVRDRVHSAGDFTAAWRHLREIFRREKADNVAWVWSPTAGGFRGGEAEAFYPGDDQVDWIAAEVYPGGTYDYRDFSEAARFFMDWADERPKPIMIPEFGVPRSYGERRAEWLRKTATYLQDPQVKAVVYYDSDEGGADESGERRYEYSTAGDRTALSALRELATTPYFNPRNLPVTAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXM7</accession>
    <name>A0A1H6AXM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53369">
        <property type="protein sequence ID" value="SEG53369"/>
        <property type="gene ID" value="SAMN04489712_10689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="175"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG53369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="28131" checksum="E7D271E53194C46F" modified="2017-01-18" version="1">MRTSLTPQLDVRRAADRFKTDFGWLDSKHSFSFGHHYDHDNTHHGLLLVNNDDIVTPGTGFDTHPHRDMEIVTWVLRGSLVHQDSTGHNGVIYPGLAQRMSAGRGILHSEKNDSWRLQGERHDEPVHFVQMWVVPDEEGITPGYEQLEIDEKLLSSGALVPVASGMERHDGEAAIRIKNRYAALYAARLAPGQSVHLPEAPYLHLFVPRGAVDLEGAGALGTGDAVRFTATGGQRVTASELAEILVWEMHATIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B530</accession>
    <name>A0A1H6B530_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sirohydrochlorin cobaltochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55722">
        <property type="protein sequence ID" value="SEG55722"/>
        <property type="gene ID" value="SAMN04489712_106253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG55722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="32681" checksum="F976A1D30B5954A0" modified="2017-01-18" version="1">MKPPLLMVGHGTRDDAGVAEFGRFVERLRSRMPVDVAGGFIELSAPPLTEAAAELYGRGHRRIAAVPIVLVAAGHGKGDIPAAMAREQVRHPGLSYVYGRPLGPHPTLLALLEERLRAVQPPGEQDTAVLLVGRGSTDPDANAEVHKVARLFWEGRGAGGPDQGAGLMAVEAAFVSLARPSVAEGLERCRRLGARRVVVLPYFLFPGVLPDRVVAEAREYAAAHPELDVRCAEVIGDCDGLADLVAERYEEALAGDIRMNCDTCVYRIALPGFEDRVGAPQTPHHHPDDPAHGHGHAHGPAHGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5E2</accession>
    <name>A0A1H6B5E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-6Y C5,15-methyltransferase (Decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_106257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55764">
        <property type="protein sequence ID" value="SEG55764"/>
        <property type="gene ID" value="SAMN04489712_106257"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG55764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="45647" checksum="479FEA8608C9C9D5" modified="2017-01-18" version="1">MITVVGYDGSPLPALALERLAQASLVVGGARHLSAVPLPPGARTVVMGDVTAALDEIDKELGDRAAPSRNAADEGGVVVLASGDPGFFGIVRALRERGHRPQVLPALSSVAQAFARVGLPWDDALVVSAHGRELRRAVNACRAHPKVAVLTAPGAGPAELGRALFPQHPRVFVVCEDLGGPDERVTRCRPAEATTRHWRDPNVVLVLDERRPAEERGWIAGARPGPPSWALPEDAFEHRNSVVTKAEVRAFALARLGPRVGDLIWDIGAGSGSVAIECARFGAAAVAVERDAASCERIRGNVRAHGVRVAVSRGEVPAVLEHLPDPDAVFVGGGGPDVVRACASRALRSVVVALASIERVRPALDALTAEGLTAEAVQLQANRLSPLPGDVHRLAATNPVFLVWGERNAGPPPARAARPARRPQTLAELPETDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B626</accession>
    <name>A0A1H6B626_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_106241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55576">
        <property type="protein sequence ID" value="SEG55576"/>
        <property type="gene ID" value="SAMN04489712_106241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG55576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="36766" checksum="AD18647E39DA8A67" modified="2017-01-18" version="1">MFDSAALWAAAPLFDTDERPETYCGEKPLMPCRLFWNITHSPDATKFVKDYHLDLWTNRLFVIVLTLSIALLLRRFAHGMITKITARMAEGTMPERLRERSRTAFDGSHAVLSERRRQRAKTLGSVLRSIASIVIMGTAVFSALGELGLNLAPILASASVIGVAVGFGAQNIVKDFLAGLFMLLEDQFGVGDVVDLGPAKGTVEAVTLRVTRIRDVNGVVWYIRNGEIMRVGNESQNWARAVLDIPVDYGEDTAKVKEVLKATADRLADDPAWKEIILEEPSVWGVQGLTGEAVVVRLVVKTAPGRQGEVARELRERVKRSFDDAGVTVATPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B9P7</accession>
    <name>A0A1H6B9P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56896">
        <property type="protein sequence ID" value="SEG56896"/>
        <property type="gene ID" value="SAMN04489712_106345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03859">
        <property type="entry name" value="M14_CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033810">
        <property type="entry name" value="Carboxypeptidase_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293500" evidence="1">
        <location>
            <begin position="29"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG56896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="47732" checksum="0948C1E9D927B882" modified="2017-01-18" version="1">MRRRPLLAMLGLCVLLVVSALAGTGASAQTAAVAPESQETHAYDVTGLRNAADRTLIARTGAAIDEAHGRHVVITATAQEVAAVRRLGFTVTRLPAEQTGRQEATTLDFPPADSGYHNFAELTTLVNQVAADHSSIVRKSVIGRSYEGRDIMAVKISDNPGTDEAEPEVLFTHHQHAREHLTVEMAVYLLNELTDKYGTDSRITNLVNSREIWILPDLNPDGGEYDIATGTYRSWRKNRQPNSGSSAVGTDLNRNWAYNWGCCGGSSITPSSATYRGSAAESATEVRVTANFIRSRVVGGRQQIRAAIDFHTYSELVLWPYGYTYADTGPGLTQDDRNAHATLGQNMASTNGYTAEQASDLYITDGTINDWMWGVYKIFNYTFEMYPRTASPGFYPPDEVIARETSRNREAVLRLMEYADCVYRIINKPALCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BCP5</accession>
    <name>A0A1H6BCP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_1074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58601">
        <property type="protein sequence ID" value="SEG58601"/>
        <property type="gene ID" value="SAMN04489712_1074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="PTHR10395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="SSF49472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TR_THY" evidence="8">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG58601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="112" mass="12223" checksum="F53D26FE3A6119E6" modified="2017-01-18" version="1">MSLSTHVLDTQRGRPAARVPVRLDRYDGQTWQPLAEALTGEDGRLGDLPGGGAELTAGVHRLRFGTGPYFAGLGAETFYPEVSVIFEITDPTEHYHVPLLVSPYGYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BDG7</accession>
    <name>A0A1H6BDG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58891">
        <property type="protein sequence ID" value="SEG58891"/>
        <property type="gene ID" value="SAMN04489712_10730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG58891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="60" mass="6887" checksum="95576921C4F6317E" modified="2017-01-18" version="1">MPRPGSHQYDTKRARTRKRLEDEGVAPDKAADERAERELREQGMRPRKASERAAGPKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BE09</accession>
    <name>A0A1H6BE09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59041">
        <property type="protein sequence ID" value="SEG59041"/>
        <property type="gene ID" value="SAMN04489712_10742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
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        </source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="556" mass="59312" checksum="81D99FC699AD57C2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPS0</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Thermomonospora echinospora</name>
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        <lineage>
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            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 43163</strain>
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        <location>
            <begin position="40"/>
            <end position="62"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG62674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="436" mass="47386" checksum="6428028AAB8C7E76" modified="2017-01-18" version="1">MNMDTLLRQTLREWAEEAEVPQGLADRALRRRGRRRISRLSVGAGATALVTAGVLLAAQAVVTDSGSLPKEDTVSLPLSRPGMGGDDVRTDPGSSPPKKFVAAKQTALSAYYVTQSWGGSKLGPPDGFSRTWYLYDSTVGTYRKTPWAYLDVAPGLRLAAVLEGPLPASRVGIVDTAGGKVLRWVPLRPGAAGVAWSPDGDRLLVTHYTDNPDEHLEPNRAQPAWPGQDRLMASATPTSSGDGRTGYSVIDIRSAKAVFHRLPPEHNNINYRQDLGWSRDGRLIWSPTATEPSRVYYEIGGGRTEGEPTSFQEAGLSPNGRYLATNPVRRQMPNGKLSIEEIEEILKNEPTGPLTRVVETATGREVGTQPMLQLVAWADDAHLIGLGCGTATCRGKGEFHNRFVMVDIAGKEIVPLTGFRENSQEPGSWVPLFTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BX88</accession>
    <name>A0A1H6BX88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 6">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 6"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65311">
        <property type="protein sequence ID" value="SEG65311"/>
        <property type="gene ID" value="SAMN04489712_10894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="26"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG65311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="45350" checksum="6A456918FE2742D2" modified="2017-01-18" version="1">MTLLPEEIKKDFPLLARTVRGGRPLVYLDSGATSQKPRSVLDAEREFYERHNAAVHRGAHLLAEEATDAFEGARATIAGFIGAVPGEIVFTKNATEAINLVAYSLSNAATAGPQAERFRVGPGDEIVVSEMEHHANLVPWQQLCQRTGATLRWFGITEDGRLDLAELDALVNERTRLVALTHQSNVLGTVPPVEQITARARQVGALVLLDAAQSVPHQPVDVAALDVDFLAFSGHKMLGPSGVGVLWGRRELLEVMPPFITGGSMIEVVRMEGSTFLPPPQRFEAGVPMTAQAVGLAAACDYLSELGMDRVHAHEEALTAYTLEQVGDIPGVRIIGPRSTRARGGTVSFVVDDLHPHDVGQVLDELGVAVRVGHHCAWPICRRFGIPATTRASFYVYNTLADVDALADGIRHAQKFFGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYJ8</accession>
    <name>A0A1H6BYJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose:LPS heptosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65732">
        <property type="protein sequence ID" value="SEG65732"/>
        <property type="gene ID" value="SAMN04489712_108129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="316" mass="33488" checksum="91FF3272348111DF" modified="2017-01-18" version="1">MSRPAILMLRALGLGDFLTGVPAYRALRAAYPEHETVLAAPSALAPLADLCGAIDRLLPTGELEPIGWHGPPPDVGVDLHGNGPASHQPVAATGARTLMMYASPTAPDAKGPWWDDDEHEVRRWCRLLEWWDVRTDPTALLLDPPAVPAPVEGAAVVHPGAASGSRRWPAERYAAVAEALAAEGERVVITGTEGERRLAQEVAERAGLPPESVLAGRAGLAELAALVSRARLVVSNDTGMAHLGFAYSRPSVTLYGPVSPALWGPPLGESRHAVLWHGSGGRPGDAWGAIPDPRLLRITVREVLDAARAVRHQPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYN1</accession>
    <name>A0A1H6BYN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_108134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65772">
        <property type="protein sequence ID" value="SEG65772"/>
        <property type="gene ID" value="SAMN04489712_108134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="207"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG65772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="44624" checksum="AB3C72818DDB302D" modified="2017-01-18" version="1">MIIHMVSEHASPLAVLGGADAGGQNVHVAALATALGARGHQVTVHTRRDAPDLPDRVRLAPGVVVEHVPAGPPRPIPKDELLPHMPRFAEWLGRRWLSERPDVVHAHFWMSGYAALAAARDLDVPVAQTFHALGSVKRRYQREADTSPPERRWLEPRVAREADVVIATCSSEVQELCAYRVHPDSAVVIPCGVDLELFRPRGPVAPRGDRPRVLSIGRMVPRKGIDTVIAALAAVPGAELVVAGGPALPELDGDAEARRLRALAAEYGVADRVVFTGRVPHEEAPALMRSADVVASVPWYEPFGMVPVEAMACGTPVVASAVGGHLDTVIDGVTGLHAPPRDPAALAGRLREVLGDERWRSRLGRTGARRAHALYSWDRIAATTESVYERLAGLRAGAAVAGRAGGPAGGLVGSTKGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9H5</accession>
    <name>A0A1H6C9H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69558">
        <property type="protein sequence ID" value="SEG69558"/>
        <property type="gene ID" value="SAMN04489712_10996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="16"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG69558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="416" mass="43911" checksum="B61D2ABFA24DB4F9" modified="2017-01-18" version="1">MTRPPRVLHVVQPTTSGVGAYVADACADQQRRGWHVAVACPDEGDLARRLAELRIVRFRWAAERVPGPRTLAEARRLHRLVGAFRPDVVHLHSSKAGLAGRLLPSTARGHRPVVVFQPHGWSWPAAGGGLGWLALWWERAAARRTDLLVCVGAGEAQVGIAGRVPGLLRIVRNGVDLTRFRPAGAEEKAQARARLGIDPDARLAVCVGRVTRQKGQDVLLKAWPLVRAGCPRAELAVVGSGDRLARARRQAGAGVRFTYEVDDPRPWYAASDVVVVPSRWEGLPFTALEAMATGRPVVASDIPGLSELVAPGAGALVPPGDVGALSEALVERLSDAGTAEREGLAAAGLALGCAADRTFAELAAVVTEAVQDVRGVSAPIGVPVAAVPPGGDLRRPSGEPRAHRVPGGRPFAAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9R5</accession>
    <name>A0A1H6C9R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_109111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69739">
        <property type="protein sequence ID" value="SEG69739"/>
        <property type="gene ID" value="SAMN04489712_109111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG69739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="27683" checksum="63E3C0D0B5DCF385" modified="2017-01-18" version="1">MTQRIKPQGEALRLVSVRKVYGTEDNPVTALANVSLSLSAGTFTAVMGPSGSGKSTLLQCAAGLDRPTEGRVYVDGTEMTGGSEAELTKFRRKRIGFVFQQFNLLPTLTVLQNVLLPLKLAGRRANPDAAVDILRRVGLGDRLGHRPAELSGGQQQRVAIARALVTSPKLIFGDEPTGALDTRSAREVLTLLQETVRFYGRTVVLVTHDPVAASYADSVLFLADGHLVGHLADPTAEAVAERLTRLGDEVAARRAMSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEC3</accession>
    <name>A0A1H6CEC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamyl:cysteine ligase YbdK, ATP-grasp superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70696">
        <property type="protein sequence ID" value="SEG70696"/>
        <property type="gene ID" value="SAMN04489712_109193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016602">
        <property type="entry name" value="UCP012666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012666">
        <property type="entry name" value="UCP012666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="492" mass="55717" checksum="F8E20ABBCD40C629" modified="2017-01-18" version="1">MGKDVPRFAISGEDRRRYRDKVRRNLDVLARMLRESQFEFDRPHIGLEIELNLVDGRGEPLMRNADVLKAIADPRWATELGQFNIEMNIPPRELGGGGTGELEREILGYLDHAIARATELGGGLIMVGILPTLRESDIGEEALSANDRYKLLNEQIFAARGEEMHIRIDGAERLAIDIDNIAPESACTSAQFHLQVSPDGFAPYWNAAQAISGVQVALAANSPFLFGRQLWHETRITLFEQATDTRPVELQSQGVRPRVWFGERWITSVFDLFEENTRYFPALLPLCEEEDPIATLERGDIPQLGELSLHNGTIYRWNRPIYAVVDGRPHLRVENRVLPAGPTVADIVANGAFYYGLVRMLAEEERPIWTRMSFRTAEDNLHRAARDGIGASVHWPGYGELPVAELTLRKLLPLAYEGLDKWGVDPARRDRLLGIIEQRCLTGRTGASWQIETVRAMEESGRDRQEALRLMTRRYIELMRTNEPVHTWPIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJS4</accession>
    <name>A0A1H6CJS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73168">
        <property type="protein sequence ID" value="SEG73168"/>
        <property type="gene ID" value="SAMN04489712_11079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="742"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="560"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="716"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG73168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="832" mass="84323" checksum="5A4337CC3FA88047" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKT4</accession>
    <name>A0A1H6CKT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73614">
        <property type="protein sequence ID" value="SEG73614"/>
        <property type="gene ID" value="SAMN04489712_110132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="18"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="13863" checksum="DF5D299174440D60" modified="2017-01-18" version="1">MTTSTTVEEYLASLSEAQRQIADKLLPLIEQVLPGTGAMWHGHPVWSLGDKPGKSPVCLLKAYSSYVTFGLWRGQQVNDPSGRLEAGARTMATVKLRTPDDIDGDLFTDWLHQARALEQPDKPDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM69</accession>
    <name>A0A1H6CM69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_110185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74061">
        <property type="protein sequence ID" value="SEG74061"/>
        <property type="gene ID" value="SAMN04489712_110185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045008">
        <property type="entry name" value="ACX4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43188">
        <property type="entry name" value="PTHR43188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="132"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="244"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG74061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="42961" checksum="9CD2FC94B6BE9D44" modified="2017-01-18" version="1">MADVLTGDFYRFEELLSEQERETLLRVREFLREEVVPIANEYWARAEFPLELVKGYADLGIAGLAYDETPGPRPSSLLSGFLAMEMARADPSMATFYGVHTGLAMGSIAACGSAEQRERWLPPMSRMELIGAFALTEPHGGSDVAAGLETTARREGDTWVLDGAKRWIGNATFADLVVVWARDVEDDQVKGFVVEQGTPGFTATKIENKIALRSVQNADIVLDGCRVPERDRLPKAESFRDTAAILGRTRSGVAWQAVGVMLAAYEIALEYAKEREQFGRPIGQFQLVQDLLVKMVGNVTSSLGMVVRLAQLQDAGTYRDEHSALAKAYCTTRMREVAGWARELLAGNGIVLDYDIGRFVADAEALYSYEGTREINTLIVGRAITGLSAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSL3</accession>
    <name>A0A1H6CSL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ca2+:H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75605">
        <property type="protein sequence ID" value="SEG75605"/>
        <property type="gene ID" value="SAMN04489712_11162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="202"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG75605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="35443" checksum="AC5497582D93F02D" modified="2017-01-18" version="1">MLALALSWGRTPPTALAVLVALFLAGSVLAAVHHAEVVAHRVGEPFGSLVLAVAVTVIEVALIVSLMISGGDKAATLARDTVFSAVMITCNGIVGLSLLFATIRRRVAVFNAEGSGGALATVTTLATLSLVLPTFTTSKPGPSFSPAQLAFAAVASLILYGLFVLTQTVRHRDYFLPVNSSGTVIEAEEHAAAPTARRALISLGMLLIALIAVVGLAKVESPIIEKVVIEAGLPPAVVGVVIALLVLLPETLAAVRAARRDRLQTSFNLALGSAMASIGLTIPAIAIASIWLSGPLTLGLGATHMVLLALTVAVTTLTVVPGRATLLQSGVHLVLFAGFLFLAVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUK9</accession>
    <name>A0A1H6CUK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper ion binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76363">
        <property type="protein sequence ID" value="SEG76363"/>
        <property type="gene ID" value="SAMN04489712_111154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000428">
        <property type="entry name" value="Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00944">
        <property type="entry name" value="CUEXPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7082" checksum="905422F7B333F268" modified="2017-01-18" version="1">MSTSTYTVVGMTCGHCVMSVKEEVGEVPGVTGVEVDLDSGRMTVTSDGPLDGSRVRDAVEEAGYQLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVN9</accession>
    <name>A0A1H6CVN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty-acyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77024">
        <property type="protein sequence ID" value="SEG77024"/>
        <property type="gene ID" value="SAMN04489712_111238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="445"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG77024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="541" mass="58958" checksum="C7A6F76AE5351ABC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVW6</accession>
    <name>A0A1H6CVW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H dehydrogenase (Quinone)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76937">
        <property type="protein sequence ID" value="SEG76937"/>
        <property type="gene ID" value="SAMN04489712_111227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="22609" checksum="628C8425EC976889" modified="2017-01-18" version="1">MSYDLSGQVRVAVIYYSATGTVYELAKTAAIAAEKAGAEVRLRKVREMAPQEVISANRMWTEHVHATRHIAEAGLEDLDWADAVLLGAPTRYGMPAAQLKQFIDTTGPLWGQGRLINKIASSFTATATAHGGQEATILALNNTFYHWGAIIVPPGYADPVQFRAGNPYGTSHTSQNGEIPPGDVQLAAMEFQARRVVDIAQAFKRGRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CXU8</accession>
    <name>A0A1H6CXU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77216">
        <property type="protein sequence ID" value="SEG77216"/>
        <property type="gene ID" value="SAMN04489712_111265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG77216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="81" mass="8784" checksum="FA8100025382C034" modified="2017-01-18" version="1">MTVGLEFTRRVPPVRLVAVGGGAATLELDIRDELRRQNDLVHGGVLTYAGLRPSSWPGTFWGDGNPPRADEVIEAERGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYG0</accession>
    <name>A0A1H6CYG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reductase C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78082">
        <property type="protein sequence ID" value="SEG78082"/>
        <property type="gene ID" value="SAMN04489712_11225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reductase_C" evidence="1">
        <location>
            <begin position="148"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="28550" checksum="E643C4DAC1B60FE6" modified="2017-01-18" version="1">MSLRADRQIAETPRLSVKSVQAYLTLVHPGTGCMGPAPVRRAGHVDAEVCVVALGAVRNVEWLADSGLAAGPRGIACDAGCRAFNMYGIVTDDVFVAGDVSRFPHPLFEYQLLSLEHWANAVAQAEVAAHNMVNPGPLRRPHLTVPTFWSSQFGLNIKSVGVPTFSDHVVIAQGSLKERRLAMVYGYRGRVTAAVTVNMAKSLDYYQHLIETAAPFPPAPGAADRPIEAEILIPSDVPDPRGLSHGPTVALTGHLPDRRLTVVRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D045</accession>
    <name>A0A1H6D045_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78398">
        <property type="protein sequence ID" value="SEG78398"/>
        <property type="gene ID" value="SAMN04489712_11272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG78398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="292" mass="31278" checksum="B8540DC92DACE81A" modified="2017-01-18" version="1">MTGSSLERMLAIFDVEPLDTAPAAPARFAGDSDGGGRQVVDGSQILAQSLIAAGKALPGRTVRSAHALFVAVADPDERLEFTVTPVRAGRSFASATVTVGQRDRICATGTVLLDHPQPDVIRHDRWTGPPVAGPDAAHPVDMPLRGRRIRLEGIKDYGSPDEVGPPIIDAWVHYDAVPERDDLRRALLAHFTGHLSISTTMRAHPGIGTSQAHHTVSTAVMGIGVSFHDPVRWDGWIRYHHESVYAGAGMSHVRGQILTEDGRLLASFTQDGMIRAFDSRGSATSLPAGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0U1</accession>
    <name>A0A1H6D0U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78777">
        <property type="protein sequence ID" value="SEG78777"/>
        <property type="gene ID" value="SAMN04489712_112124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="47" mass="5061" checksum="27F2479BEF5A3A6F" modified="2017-01-18" version="1">MQVWTAVATGASFLPAAGYNLKAVQETLRLPSITAAAVGRRWDALWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1I6</accession>
    <name>A0A1H6D1I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (Catechol pathway)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78645">
        <property type="protein sequence ID" value="SEG78645"/>
        <property type="gene ID" value="SAMN04489712_112105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="284" mass="30433" checksum="51325F515152860F" modified="2017-01-18" version="1">MRVANLNDRAVLLAGDGAIDVEYASSGRFGPALSAVYERWDEFSAWATNAPRLPDPEPYSRADLRAPVPAPRQVFAIGLNYHAHAAESGLAAPEQPVVFTKFPTCITGPYDDITLPEGGHTDWEVELVAVIGRTARHVPEADAWNHIAGLTAGQDLSERITQLAGPAPQFSLGKSLPGFGPIGPCVVTIDEFDDPDDVALGCRVGAECVQQARTGDMIFSIPRLVEVLSAQLPLLPGDLIFTGTPAGVGLGRTPQRWLAPGDELVTYIETIGEMRHRLVATPHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1L9</accession>
    <name>A0A1H6D1L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_112126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78803">
        <property type="protein sequence ID" value="SEG78803"/>
        <property type="gene ID" value="SAMN04489712_112126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG78803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="333" mass="36021" checksum="A733C180913AF7BE" modified="2017-01-18" version="1">MNMIGGGGAAIRTRGLRKTYGAVEALRSLDITVDAGETFGFLGPNGAGKSTTIAMLCTLLRPTAGRAEVAGADVVRAPHDVRRRVGVVFQESTADNDLTAEENLRFHAELYGISRRESRRRADFLLDLLALSSRRKALVGTFSTGLKRRLEIARSLMHRPEVLFLDEPTAGLDPHSRALVWDHLHRLQQQQVITIFLTTHYLEEAEHCHRIAVVDGGGVIAEGSPQQLKAEVGSDVVHLQTADNAVAARSIRDRFGLNPALGPDGVRVHAANGAELVPRLCAASAVPVHSIMVTRPSLDDVFLHYTGRGVPGPPRWRDERAPLSAAPDGKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1R7</accession>
    <name>A0A1H6D1R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79014">
        <property type="protein sequence ID" value="SEG79014"/>
        <property type="gene ID" value="SAMN04489712_112154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="33"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="17466" checksum="54A1CC3F60750B14" modified="2017-01-18" version="1">MGNCRTGYQSAAEWLRSPEPLRWRRTYPGRLDQVAVARRFAVSLFAGTGYEDEVGFIVTELASNAVRHSYSGHRGGWFGLEVVLDDVAYVGVTDQGGGGVPIVLPELPDQPMTEHGRGLRAVSKLAMALGIHGSGDGGHTVWADLDLCAETGTRPDLQAVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4G6</accession>
    <name>A0A1H6D4G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-rhamnose isomerase / sugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80232">
        <property type="protein sequence ID" value="SEG80232"/>
        <property type="gene ID" value="SAMN04489712_11345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013457">
        <property type="entry name" value="Rhamnose_iso-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02635">
        <property type="entry name" value="RhaI_grampos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="74"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="42907" checksum="1EA45188493C4128" modified="2017-01-18" version="1">MSDISAVKDALRRQHIETPSWAYGNSGTRFKVFAQPGVPRTPQEKIDDAAQVHRYTGVAPTVALHIPWDRVDDYGALAEYARAAGVRVGAINSNVFQDDDYKLGSVTNPDPAVRKKALNHLLECVDIMDATGSRDLKLWFSDGINYPGQDDIHARQDRLAEALSAVYERLGDDQRFLLEYKFFEPAFYATDVPDWGTAYAHCLRLGPKAQVVVDTGHHAPGTNIEFIVAFLLREGKLGGFDFNSRFYADDDLMVGAADPFQLFRIMHEVVRGGGYDEQTGVAFMLDQCHNIEPKIQGQIRSVMNVQEATAKALLVDADALRAAQRDGDVLAANAVLMDAYNTDVRPLLAELREEMGLDPDPIAAYLRSGYLEKVIEERKDGTAAGWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4I0</accession>
    <name>A0A1H6D4I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolases family 2, sugar binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80210">
        <property type="protein sequence ID" value="SEG80210"/>
        <property type="gene ID" value="SAMN04489712_11340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295512" evidence="1">
        <location>
            <begin position="35"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="995" mass="108239" checksum="D3C32B0A7B5487C9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8S7</accession>
    <name>A0A1H6D8S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_114105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81642">
        <property type="protein sequence ID" value="SEG81642"/>
        <property type="gene ID" value="SAMN04489712_114105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041483">
        <property type="entry name" value="TetR_C_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17929">
        <property type="entry name" value="TetR_C_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="25001" checksum="40507771ADB6AF21" modified="2017-01-18" version="1">MTGFQRARSPEQQEERRRTILDTTAGMLAQMPAAKIGLNELSRQAGMAKSNVLRYFESREAILLELLDRAWSEWNSALPALLDAAIDPAAPVARRAEVYAQVYAVSLADRKVLCDLFSAQAGVLEHNVSPDVAARYKRAAAVNLTALTALTRHHLPELGDTTQQACAQILMATGAIWTHSRPSPAMLEAYAKDPALAALSMDFAPALQETVATLIAGTLSRAEPRDQPIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DA50</accession>
    <name>A0A1H6DA50_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81565">
        <property type="protein sequence ID" value="SEG81565"/>
        <property type="gene ID" value="SAMN04489712_11485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG81565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="451" mass="49663" checksum="BA52A6DC7CE86D07" modified="2017-01-18" version="1">MPRTAVQAPPQEATTAPLEDLLERGRAQGHLSLGEVRAAFEAAGISPAQGRSILREISEAGVSLASEDETPAAASATARRPARGKAAAGKRRTARAKADAAAQEPGGPADAPVSVADDDAFQIEAVEPTEPIEAAEAETEPADLDDVSSSMGDSVHTYLKSIGRRQLLTAEQEVELAKRIEAGLYAEYKLENEVGLSPDMREALEWVAEDGRRAKSHMLEANLRLVVSVAKKYSDRGLSLLDVVQEGNLGLIRAVEKFDYTKGFKFSTYAMWWIRQAIQRGFADSARTIRLPVHVLEMLSKLSRVERDMHQRLGREPTPEELAAELDKSPAQVRELLRTSRQPISLDSTIGEDGETRIGDLIEDIDSPEASEMVDRQLMADQLRRTLSILSPREETIMSMRFGLYDGTPRTLDEIGRHLGLTRERIRQLEKESLSKLRHPSNAMPLLDFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAQ1</accession>
    <name>A0A1H6DAQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82411">
        <property type="protein sequence ID" value="SEG82411"/>
        <property type="gene ID" value="SAMN04489712_11522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="30585" checksum="BBAF53EBDB897733" modified="2017-01-18" version="1">MEYDTFEKNGPALLGLGAMGTALARAWLAAGHPPTVWNRTPGRAAPLAAEGARVAGTAAEAVAASDLVVVCLLDDASVGEVLAGVDLTGKDLVDLTTGTPAQARARARWAEERGARFLDGGIMAVPPMIGAPESGGYVLYSGSRALFEAHRDTLAVPAGTRYVGEDPALAALHDTALLSAMTGMFAGIAHAFALVRDEDVALQDFASLLAGWLTAMAPHVYSTADHLESGDYTKGVTSNLAMMVQGNATLLRTAEEQKVSAELLTPFMALMERRLADGHPDEDTTGVIDLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCJ3</accession>
    <name>A0A1H6DCJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_115129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83041">
        <property type="protein sequence ID" value="SEG83041"/>
        <property type="gene ID" value="SAMN04489712_115129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="21197" checksum="3BD0494F14361C04" modified="2017-01-18" version="1">MARILLLHSMYGLRPAVHAAADRLRAAGHEVHVPDLYAGRVADTPEDAEAIREELGRDELLRRAVAAAAPHCDQGLVYAGFSLGGALAQNLALADERARGLVLLHGTSDVADDAATEIPVQLHVADPDPYETDDWLNAWYLRMRRAGADVEVHRYRGAGHLYTDPDLPDFDADATERTWRIVLDFLTDLPDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DER5</accession>
    <name>A0A1H6DER5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83789">
        <property type="protein sequence ID" value="SEG83789"/>
        <property type="gene ID" value="SAMN04489712_11667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="28150" checksum="61CF5582EABB4FAB" modified="2017-01-18" version="1">MATFCGGRETRVALDRDAAARMFDLDGRVAIVTGASSGLGASVARALASAGARVAVVARRRDRLTELAGRIGGLAVACDLSDLDRVGALVPAVAEGLEPPEILVNAAGNMFTTERAESEPLDAVRRTMDLNLLAPFLLAQAVFPHMRAVGRGAIVNVSSISGRVGIPGIPQASYAASKAGLSGLTAELAVQWARHSIRVNTVAPGFFRSEITSPLYESERALEYLRRNTPLPTEGTADDIVGAVLWLVGDAGRYVTGQTVVVDGGWTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGT7</accession>
    <name>A0A1H6DGT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83816">
        <property type="protein sequence ID" value="SEG83816"/>
        <property type="gene ID" value="SAMN04489712_11673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="264"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="423" mass="44018" checksum="DACE4C5BFF05302F" modified="2017-01-18" version="1">MTVVATAGEVDLGRFLRPGDRIVIGQACGEPTTLVEALIEQGGTIGGLSAFIATSFSGLFTPAATDACALSSMGAIGALRSLTRAHRLSVIPCHVSQVGPMIEAGIIGCDVALVQVSPADANGDHSLGLISDYVQAAVARARVVIAEVNEQVPYTHGELLPAARIDYAVPVSRPPVQVPPARITETDEAIARHAAAYIEDGAVLQTGVGAVPDALLRLLRDRRDLGVHSGMLGDGLVDLIEAGAVTNARKRIDRGVSINGALIGTRRLYEFAHRNPRIRMCATSYTHDAAVLAQLDGLVTINSALEVDLTGQVNAEQSGPAYLGGTGGQVDFVRAGARSPGGHAVIALPATAKGGTVSRITAALSGPVTTARSDVDVIVTEFGAAELRGRTLAERARRLIAVAHPGFREDLERAAHTIQRRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLP5</accession>
    <name>A0A1H6DLP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85636">
        <property type="protein sequence ID" value="SEG85636"/>
        <property type="gene ID" value="SAMN04489712_11850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="21001" checksum="62E272BF671ED256" modified="2017-01-18" version="1">MIRNECPLRVAVVIGSTREGRIGDAVGRWFVGVAGRCEGVELEVLDLLDHELPVRHPGAVTPQMAAFAGRIGQADGFVVVTPEYNRSFPASLKQAIDCAYDEWRAKPVGFVSYGYRFAGLYAVEQLRPVFTELHVVTMPGAVHIDLRHCDFARGRPPDEGLVHEAETMLGQLIWWGLALRDARAARPYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNN7</accession>
    <name>A0A1H6DNN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Forkhead associated (FHA) domain, binds pSer, pThr, pTyr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86879">
        <property type="protein sequence ID" value="SEG86879"/>
        <property type="gene ID" value="SAMN04489712_12025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="346"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="443" mass="45815" checksum="6B752965F326E099" modified="2017-01-18" version="1">MSRLDQGSPAAAPPSSASAGPVVRPLPGGGLVAHAAGMLLACDADGELADRLLAALRLAAESGADPNAGRLLIHHVARALAGSMGESMAACAVAGPADGGAAVLVSGAAIVTVSGGEGEVTLGGRTALTWTDRFVSGPVSRIELRLPGAGQADPRSRLDAGVVPGGGLEWLADAPAHAASPGRPAASRPAAQPQQAQQALLRPEVPTDPRQGASGPSAPMPVEAPTARGVPPVPAEAAPRPAPGDIPPDDIRSQPFESVLLIQPADAPAPPPPPPATRFDPEPDSRPEVWGGDCKNGHFNDPRAHYCGVCGIAMGQLTVIPRRGPRPPLGVLLMDDGMALRLDADYVMGRDPERAEQVTAGKARPARVDDQSGSVSRRHLQVRLHDWDVELVDLGSVNGTYVMPPGESEYRQIPASQPFQIHPGTMVRLGASRSFRYESHRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVI3</accession>
    <name>A0A1H6DVI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89084">
        <property type="protein sequence ID" value="SEG89084"/>
        <property type="gene ID" value="SAMN04489712_12318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="30949" checksum="D34BC2E39C2FA216" modified="2017-01-18" version="1">MAERRAARRAVPSVYRSADGRVELRPDPEREHGWLLTVEGVPQSYVDLADPTYLGFEYMRLMGDVVDCLGDGRAPIDAVHVGGGACTLARYIAATRPGSRQLVLEPDAGLVRLVRERLPLRGVRGLRIRVVDGLAGVAALPDASDDLVVLDAFADAALPLELACLEFCGDVRRVLRPGGGYLVNMADGHRLEFARRMVATVREVFPHTLLLAEPGVLRGRRFGNLVLAASDTELPVAELTRRAAGGMVRARCMDTDALAGFCAGAAPLRRGEHVMVPVPPETAFGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVX9</accession>
    <name>A0A1H6DVX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,4-dienoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88755">
        <property type="protein sequence ID" value="SEG88755"/>
        <property type="gene ID" value="SAMN04489712_12273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="8"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="387"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG88755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="630" mass="66476" checksum="90AD1C3C2366CED5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWD4</accession>
    <name>A0A1H6DWD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine catabolism dioxygenase TauD, TfdA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89394">
        <property type="protein sequence ID" value="SEG89394"/>
        <property type="gene ID" value="SAMN04489712_12383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="45"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG89394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="32706" checksum="07B17649757D82F7" modified="2017-01-18" version="1">MPTVNGFDRFRYPIRPELPAFLRGEDSGGPTMRKLCSWLDSLVTELESWPGLCVLQGFPEGIWTDHRAVLRFSELLGTPIPQDRHGTVVREVRDRGSTIGQGESTRYADSRFGGHFHTDGAEAGFPVPDMFALFCVRQAMRGGSLHLAHLRDVVRELAGQEAVVDVLGRPFHFHRRGDGTGDAEHTVAKPILFDHRGRPAVTYLRRYVELGHRQRGAPELTAGQHAALDAFDAAVDRTRKIEGRMRPDEVLIVNNLRTLHARTEFVDHPDPARSRLLLRTWISRDERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWQ3</accession>
    <name>A0A1H6DWQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89153">
        <property type="protein sequence ID" value="SEG89153"/>
        <property type="gene ID" value="SAMN04489712_12332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DRTGG" evidence="2">
        <location>
            <begin position="207"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PTA_PTB" evidence="1">
        <location>
            <begin position="365"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="680" mass="71961" checksum="4714E0ACB31515A8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXM9</accession>
    <name>A0A1H6DXM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90092">
        <property type="protein sequence ID" value="SEG90092"/>
        <property type="gene ID" value="SAMN04489712_12536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="30"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="420"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG90092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="592" mass="64370" checksum="A6D641ABFFEBB57F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZB9</accession>
    <name>A0A1H6DZB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG89985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89985">
        <property type="protein sequence ID" value="SEG89985"/>
        <property type="gene ID" value="SAMN04489712_1256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="170"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="37690" checksum="45BB95430E1FDBD7" modified="2017-01-18" version="1">MDIDQDKLHDFLHRFVGDLGAVMAAGGIVVGERLGLYQALADKPQQPAELAERTGTAPRYVEEWLRGQAAGGYVEYDENSGVYSLTAEQAFALTDPDGPLYAPGAFQLALGALRALPQVTAAFRTGEGVGWHEHDEDVFIGCERFFRPGYTAHLLTDWLPALDGVGAKLNSGARVADVGCGLGASTILMAQAFPRSEFVGSDYHEGSIAKARSRAADAGCDDRLTFQVASAQTFNGGPYDLVTTFDCLHDMGDPLAAARHVRRSLAPDGTWMIVEPFAGDTVADNLGPVGRVYYSFSAFLCVPNALSQDGGYSLGAQAGERPIRELTAEAGFTRFQRVAETPFNIVYEVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZH0</accession>
    <name>A0A1H6DZH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90045">
        <property type="protein sequence ID" value="SEG90045"/>
        <property type="gene ID" value="SAMN04489712_12523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="30382" checksum="271701AFFD8395D9" modified="2017-01-18" version="1">MSIDHAAQRVALADPALGRRTPGEEFAWAVAGAPQGTDVVVPFRVALPQSFPLFATRPRYAVRHLLKTATVPDRAVPYVHEAPQAGPAHAGTTYATVPESGFTSSVRSAGLTDLSVTVPLPKGLVDEPSLLAAFIDYRVLVRLSAVENDALLHGTPDGVIEGLLTLPQARRGPLAGDLGDVLTAAAAEVETTGGSCDGIVVHPAVYWRLVRAGLLGLLNAAGIMVSRTRMIAEGQVLLGDFKAAVTLLDPGVGSLVLHRGAGPDGTDTVEARTRSGLALHLPQHFLLLSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0N9</accession>
    <name>A0A1H6E0N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91178">
        <property type="protein sequence ID" value="SEG91178"/>
        <property type="gene ID" value="SAMN04489712_12855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="170" mass="17708" checksum="F91FF111FD2E904D" modified="2017-01-18" version="1">MSGVVTLVGNPRAGSRTRHAAVEAARVVARRIGRTGPDEVIDLSGLAAQIYAPEPSGDLDHALKLAAGADVLVVASPTYKGTYTGLLKSFLDLLPSGALASTVALPVLVLGHPRHSLAVEVHLRPLLVELGARVPTPGLALLESELPDLDEVLAEWADRIVPQIVLEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E398</accession>
    <name>A0A1H6E398_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline phosphatase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91683">
        <property type="protein sequence ID" value="SEG91683"/>
        <property type="gene ID" value="SAMN04489712_13020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296480" evidence="1">
        <location>
            <begin position="38"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="35914" checksum="DACDBF3778472CEB" modified="2017-01-18" version="1">MTGQSDRNLTRRTFLAATGAAAGSLALTSGPERTAAAAAQAATDAVVPLARSVQRSWLGPDFWANRLQDWHLADGRIEGIAKPGPHRLRTIGILTRELTGDGAARLRVRTGTLAPGPGFSGFLVGAGAGALDPRAAALVQGPSGEGGGLLAVYGSDGQVAFRDHAEESRPFAFTAFPAKVDTPAAGPRTLDEDVELVLELKPSGGGDLRLRLYARDRRTDRILSSATLEGVAPERVRGGFSLVESDDRPVQGARFWFSDLHATGPGVTIHRDRAFGPIVGTLFSVSGSVLKLTAQLVPLGPDDPRELYRLNRDLGELTDVAAEHPALVRKAERLLAGAVSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E406</accession>
    <name>A0A1H6E406_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92390">
        <property type="protein sequence ID" value="SEG92390"/>
        <property type="gene ID" value="SAMN04489712_13338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019681">
        <property type="entry name" value="DUF2530"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10745">
        <property type="entry name" value="DUF2530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="115" mass="12557" checksum="7FD1D3DEA1DA1E06" modified="2017-01-18" version="1">MTSPRRPDPPPLRTDDRLIAAVGSAAWAIALVVLLIVGLPEHDRWWLWVCATGIAIGGFGYWYLPRLHRGRAAAVQRRTDRGARQTPLPDRPSESGTADAEDAVADETPRAQPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7T9</accession>
    <name>A0A1H6E7T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93321">
        <property type="protein sequence ID" value="SEG93321"/>
        <property type="gene ID" value="SAMN04489712_13819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="501" mass="55596" checksum="CA8303157CF30A2B" modified="2017-01-18" version="1">MRPSATSVASGTSPVPVMSPVVADMIARVADPHAWQKWARQVEHAGHCVRPVRIYGRAFAVDTATGEIRATYSSAEEPDGSLLVACKDRRAAVCLACSRIYRADTWHLVAAGLRGRRPTDEALREQDGTAVPASVADHPAVFATFTAPSFGPVHRITPEGRRCRLRRARPTCPHGTRLWCPDAHGPDDPHVGTPLCYECYDYPGHVLWHAVMPELWRRTVIYLYQELARLASRRTGRPMGVRTVRRRLRVSYVKVTEWQRRAAIHLHAVIRLDGINADDPAAIVPPPSWADVGLLEEAIRDAAARMSLPLPAVDHHRRTAVWGKQLDITTVNAPERAAAYVAKYATKTAGDILPHLPVTRFEASDLARLRRRGLSPHVSLLASTCFLLDQRPECADLRLARHAHTLGFAGHFATKSRRYSTTLTALRIARRNWRTRTGGGAAADPWSHRNDTTVMVGDWRMVGLGYLRPGDVELAATLAREHREAREHARETAGHQEDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E896</accession>
    <name>A0A1H6E896_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4145 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93369">
        <property type="protein sequence ID" value="SEG93369"/>
        <property type="gene ID" value="SAMN04489712_13833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025285">
        <property type="entry name" value="DUF4145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13643">
        <property type="entry name" value="DUF4145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4145" evidence="1">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="29887" checksum="1B6032A48E4367E4" modified="2017-01-18" version="1">MDERRRTLRCLKYELYGEAALSMRKIIEAICATGGYSTKDMSLKAAIDNRFHAHPRLAAWAHQIRFLGNDHAHFGHAEITKADVYDALALLNAIYDVEAGYSSEPFTELAAEALKLRRNPTGQQGYVGAERYWFGGEDPLLRARSRGSYLISGIEEAIAAGARSGSVDWEEEGASLGDVTLAWSVDKIKNIIGVDPAIFGNSGYVCTGASLPITAHAFDWDAVHDLWYEGLDAWLETGEGSDWRYREVAEYHANLCDSPYCPHGEYHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8Z9</accession>
    <name>A0A1H6E8Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_14029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93753">
        <property type="protein sequence ID" value="SEG93753"/>
        <property type="gene ID" value="SAMN04489712_14029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="146"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="218"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG93753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="450" mass="49128" checksum="2EFFE32F46CDD165" modified="2017-01-18" version="1">MNDTGRQMHLAVFAQGLGAAQSVWRSPRTEPDKVHTLGHWARVAQVAEEGKLDAVFIADALNLSTSIGSDATERPDPIAVLSALSAVTSRIGLVGTSSTTYNQPFTVARQFATLDHLSGGRAGWNIVTTAIAAAAGNYGSAELPEHEARYERAEEFVEVVTRLWDGWQEDAIVLDREAGVYADLARIRRLDHEGGHFTVRGPLTIPRPPQGWPLLVQAGSSPTGMNLAARFADMVFTTQFDIKDARAFVDRMRELVTAKGRDPFAVAVMPGVTPIVGRTVQEARDLARELGDLVRPEATLAFMQQMFGGIDFTVYDLDEPFPDVRDLLPPHASVSRPRLFMAMAEEEGLTLRQVAQRIGLSTGHRSIVGTPDQIADELATWFTEEAADGFNLMPADLPRGLEDFVEEVVPRLQDRGLFRKEYTGSTLREHLGAPAPEPVHGNGPSMAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAT8</accession>
    <name>A0A1H6EAT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94343">
        <property type="protein sequence ID" value="SEG94343"/>
        <property type="gene ID" value="SAMN04489712_14621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="914" mass="98985" checksum="B29EABF3C4A4ADF2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S109</accession>
    <name>A0A1H5S109_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="6" type="ORF">SAMN04489712_10113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43598">
        <property type="protein sequence ID" value="SEF43598"/>
        <property type="gene ID" value="SAMN04489712_10113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="33"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF43598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="30093" checksum="9E443FA3A51810D4" modified="2017-01-18" version="1">MRKVPAHITRPEYVGKKRPRTGEPDVKSPEMIERMRVAGRIAAQALEEVGRHVRPGVTTDELDRIGHEFLLDHGAYPSTLGYRGFPKSLCTSINEVICHGIPDDTVLRDGDIVNIDITAYIDGVHGDTDATYLCGTVDEESRLLVERTREAMMRGIRAVAPGRAVNVIGRVIEAYARRFGYGVVRDFTGHGIGTTFHSGLIIPHYDDPNATTVMQPGMTFTIEPMLTLGTIDYDIWQDGWTVVTKDRRRTAQFEHTIVVTEDGHEILTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S1A0</accession>
    <name>A0A1H5S1A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribosyltransferase exoenzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44260">
        <property type="protein sequence ID" value="SEF44260"/>
        <property type="gene ID" value="SAMN04489712_10136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003540">
        <property type="entry name" value="ADP-ribosyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03496">
        <property type="entry name" value="ADPrib_exo_Tox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ADPrib_exo_Tox" evidence="2">
        <location>
            <begin position="608"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF44260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="743" mass="78913" checksum="FB44E1382D51FCCF" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SD35</accession>
    <name>A0A1H5SD35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiamine-phosphate synthase</fullName>
            <shortName evidence="9">TP synthase</shortName>
            <shortName evidence="9">TPS</shortName>
            <ecNumber evidence="9">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="9">TMP pyrophosphorylase</shortName>
            <shortName evidence="9">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiE</name>
        <name evidence="13" type="ORF">SAMN04489712_101140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 10">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9 10">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 9 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47741">
        <property type="protein sequence ID" value="SEF47741"/>
        <property type="gene ID" value="SAMN04489712_101140"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="12">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="9">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="9">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEF47741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="24413" checksum="8CAB56640AEB8A51" modified="2017-01-18" version="1">MSRHLLSDRAVALRARLDRARLYLCTDARERQGDLPEFLDAVLAAGVDIVQLRQKGLEARQELEYLEVFRAACDRYGVLLAVNDRADVAYAARADMLHLGQDDLPVPYARRIVGEDVLIGRSTHSDHQAAAASAEPGVDYFCAGPVWPTPTKPGRAAPGPKLLEYTAALRTGRPWFAIGGIDAGNLDQVLATGARRVVVVRAITEAADPAAATAELARRLHEASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SN89</accession>
    <name>A0A1H5SN89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52039">
        <property type="protein sequence ID" value="SEF52039"/>
        <property type="gene ID" value="SAMN04489712_101289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF52039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="18904" checksum="585FA428831C2832" modified="2017-01-18" version="1">MRKMPLRELAERAGASPSFVSQLERGRTSASIGMLRRIAGALGLTVADLFTEENEVGHRVLPRAHRPELPTGPGARKYLVSQRPLRNVEVYVGEFDPGASTGDEPYAHGDSQEIFVVLGGRVTLWLGDQDEARSYELAAGDSIEYRTSVPHRVANAAEEPAEVMWIIAPPTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T455</accession>
    <name>A0A1H5T455_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57539">
        <property type="protein sequence ID" value="SEF57539"/>
        <property type="gene ID" value="SAMN04489712_101475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="89"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF57539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="32198" checksum="4E5374ADB9C11BBE" modified="2017-01-18" version="1">MSVPEGQPIIDTMIGFPMRDPKRTYAHITRQTKDAESRQDLTMPAGYMFKDVPGHEDPPADPVAVTLAEMDRHGITVGLVGVGGEDGRRAVREHPDRFAGCLHVDPNKGMDAVREIVAAHAEHGIRAVDVFPAGTFPQVAINDKKMYPIYAKCVELDLPIFVCAGVPGPRVRLEPQRVEYLDEVMFDFPELTLVTRHGCEPWTDLAVKLMLKWPGLHYSTSAFAPRYYPREIVDYANSRGADKIIYAGYFPMGLTLDRIMTELPGVPFKDSVWPKFLHDNAARVLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T910</accession>
    <name>A0A1H5T910_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59266">
        <property type="protein sequence ID" value="SEF59266"/>
        <property type="gene ID" value="SAMN04489712_101528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF59266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="6824" checksum="B28339DA57556D37" modified="2017-01-18" version="1">MRSSTTGTPSDSARRALADPERGSLATSTLVNRLTVPITFRPAADARAASSCLGTVVSPVMATFMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TUH4</accession>
    <name>A0A1H5TUH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66444">
        <property type="protein sequence ID" value="SEF66444"/>
        <property type="gene ID" value="SAMN04489712_101751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF66444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="329" mass="35394" checksum="3099E171297FB9DF" modified="2017-01-18" version="1">MTRFAIEAEGLRKRYGDTHALAGFDLAVAEGTVCGLLGPNGAGKTTAVRILSTLLLPDGGTARVAGFDVVGDPAQVRYRIGLAGQQTSVDEILTGRENLRMWARLFRLGPREAKRRTDELLEWFGLAGAADKRVKHYSGGMRRRLDLAASFILAPRVLFLDEPTTGLDPRSRTEVWRAVRDLVAQGTTVLLTTQYLDEADRLAHQIAVLDAGMVIADGSPSRLKSMIGGDQIDVVVRDAADLPSAARIIARVADASPEIDPDAARVTAPVKDPLEAITVTARELRDAGLQVEDLTLRRPTLDEVFLSLTGRGAGADGDRPAAEKGMVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TXI4</accession>
    <name>A0A1H5TXI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family mycofactocin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67479">
        <property type="protein sequence ID" value="SEF67479"/>
        <property type="gene ID" value="SAMN04489712_101782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF67479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="29266" checksum="60328953402EEF54" modified="2017-01-18" version="1">MGRVAGRVALITGAARGQGRAHAVRLAQEGADIVAVDLCRDQPELLYSQGTPEDLAETVRLVEQEGRSIIARAGDVRDQAALDGIVAEALERFGKIDVLVSNAGISNQGPAHQLTDKQWSDILETNLVGAWHAAKAVIPSMIERGSGSIIFVSSTTGLRGVPGQVHYGASKHGIQGLMGGLANELGQHGIRVNSVNPGTVNTPMALNERLLKDYLPHLENPTLDDAAEAFKPLTLLPVPWVEPEDVANAVLWLASEEARYVTGVAIPVDCGLLAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TXQ3</accession>
    <name>A0A1H5TXQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67652">
        <property type="protein sequence ID" value="SEF67652"/>
        <property type="gene ID" value="SAMN04489712_101788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF67652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="41095" checksum="7C108BAD97EC1867" modified="2017-01-18" version="1">MSEALSHRDRCAIAGIGATEFSKDSGRSELTLAAQACRAALQDAGLTVADVDGVVSCDYDLVSYGAIADALGIADLTYWGQTGPGGSGPCAMVGQAVAAILSGQATTVLVYRALNGRSGRRYGLGAPDPDARVGGRGAYEEFFAPYGLVTPGQFFALLAQRHMSTYGTRYEALAEIALACREAANRNPAAQMHERALTLEQCLAARPISLPLRLFDFCLETDGACAVVVTSAERAADCAQPPVLVRAVAQSTGPRVQPGVMYPMLMRPDITVTPSQTVARTLFSRAGLGPSEVDVAQIYDCFTITVLLQLEDYGFCAKGEGGAFTESGALRPGGALPINTAGGNLSEGYVHGMNHVLEGVRQIRGTSTSQVTGAEVSLVTSAPPPGTSALLLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UVG8</accession>
    <name>A0A1H5UVG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78207">
        <property type="protein sequence ID" value="SEF78207"/>
        <property type="gene ID" value="SAMN04489712_10211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF78207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="17522" checksum="15286DE308E4DC61" modified="2017-01-18" version="1">MSQEQTHAIRDIAPSASLATKVEWLIANMWPADAPPPRNNVETAAAIAAATGEDISSTTVWKLRTGRQDNPQLRTLTALATFFSVPLGYFGFAAESRPMEDDLSFKALRRKLDDGTIRPEVLRAFIDLPADIRWLVDEMIVSAADAARSKERQAAPRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V1E2</accession>
    <name>A0A1H5V1E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80521">
        <property type="protein sequence ID" value="SEF80521"/>
        <property type="gene ID" value="SAMN04489712_102102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045825">
        <property type="entry name" value="RamS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19402">
        <property type="entry name" value="RamS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF80521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="38" mass="3962" checksum="F0D9F4E00B507DBC" modified="2017-01-18" version="1">MALLDLQGMTVENGGGDDSSVSLLLCDKHSSHSTILCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V438</accession>
    <name>A0A1H5V438_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82145">
        <property type="protein sequence ID" value="SEF82145"/>
        <property type="gene ID" value="SAMN04489712_102159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF82145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="22238" checksum="E370A58323830FB8" modified="2017-01-18" version="1">MDSMRSDPAHPSPGGPAEDPRESSLAVKILVAGGFGVGKTTLVGAVSEIRPLRTEAMLTEKSIGVDDTAMVAGKTTTTVAMDFGRITLPTGLVLYLFGTPGQDRFWFMWDELAQGALGAVVLVDTRRLADCFASVDYFERRGLPFIVAVNHFEGAKRYAPEQIRAALDLDEDIPVIMSDVRTRESAKQVLITLVEHVLMATARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VQU0</accession>
    <name>A0A1H5VQU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88897">
        <property type="protein sequence ID" value="SEF88897"/>
        <property type="gene ID" value="SAMN04489712_102395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF88897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="26901" checksum="E23AF7E768EC0392" modified="2017-01-18" version="1">MGLPRPPGDFDRIYSPPEPPETARRPRLVRLLLPVMGAVAVAVAAVFLLLPSGEEERGAPAPRASRGGTPASANSSSPAPSSAGPIYTALPPACRSVSAETVRRLVPRAERTSSGNTTFGYCGFGSPPSAEAKDRWLQIDSRLYPAAGAVTPVDSARRHFDIKWALAGKATEERTVTLERQSGLGEQAYRWFKVDRQRPLAIGEVAVRSRNVVITVSYSERTVGAEPSAAQRQRCLTEATAVAREVLESLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VRF1</accession>
    <name>A0A1H5VRF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin Q/BCP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89814">
        <property type="protein sequence ID" value="SEF89814"/>
        <property type="gene ID" value="SAMN04489712_102427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF89814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="16889" checksum="1C29F7CFB8D5464D" modified="2017-01-18" version="1">MSERLQPGDVAPEFELPDADGNPVSLASLRGKRVILYFYPAAMTPGCTKESVDFRDSLPELQAAGATVIGVSPDTPAKLAKFRDRDALTFPLLSDPDTEVLRAYGAYGEKKLYGKVVVGVIRSTFVIDPEGKVEKAYYNVKATGHVDRLRKDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VUV9</accession>
    <name>A0A1H5VUV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90786">
        <property type="protein sequence ID" value="SEF90786"/>
        <property type="gene ID" value="SAMN04489712_102461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF90786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="239" mass="25717" checksum="ED1E6D3DFE358FB3" modified="2017-01-18" version="1">MTRSKTDGDEGSAPEPPTAEAKTAPRRDPRGLRNLVLVAVVAVAAVLAAGALDLTPGWLNPFGTQTKDRTGPAVLKSIRDLSRYEAASGNFQVIVDLEKDAKFLPSAVRGQRTLFVGNGSVDAYVDFSKLASGAVTVNEDRTTATIRLPRAQLEQASLDPKRSYVFATQRGLIDRVGSVFSANPSDQQQLYVLASQRIQAAANESGLRERADQNTRLMLESLLKSLGFKTVTVTTVNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VZ26</accession>
    <name>A0A1H5VZ26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92460">
        <property type="protein sequence ID" value="SEF92460"/>
        <property type="gene ID" value="SAMN04489712_102525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF92460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="49" mass="4989" checksum="6F9D5142370C0ACA" modified="2017-01-18" version="1">MTVTPYVEQAGKNPKGEPITRVAYSYRATGVQAPGGAGRAARPAGKDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WAA4</accession>
    <name>A0A1H5WAA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS system N-acetylglucosamine-specific IIB component, Glc family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95747">
        <property type="protein sequence ID" value="SEF95747"/>
        <property type="gene ID" value="SAMN04489712_102628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="3">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF95747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="77" mass="7981" checksum="F90DA7FA166E2C9B" modified="2017-01-18" version="1">MDKAEAIVAALGGAANIVEIEPCATRLRTEVTDPDRVDEAGLKAAGAYGVMRSGRVVQVVVGPEADTLATDIEDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WCA6</accession>
    <name>A0A1H5WCA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4350 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96437">
        <property type="protein sequence ID" value="SEF96437"/>
        <property type="gene ID" value="SAMN04489712_102646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025646">
        <property type="entry name" value="DUF4350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14258">
        <property type="entry name" value="DUF4350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4350" evidence="3">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF96437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="399" mass="42240" checksum="00C435DAC229899D" modified="2017-01-18" version="1">MTAPATSTSISTPDAGVPTAGQVAGRRWRASRGVVLTVLALVVLAVALASMQPSVGPRYLDPESPSQGGSRALAQILGQRGVPVRTVRDAREALSAARPDTVLVIVRTERLTDEELNALRAAPGDLLLVDPTQPALAALAPGVRPATGSFQEVAGPDCALDAAVRAGEVRFELSQLYLTPPGATRCYPSEGLPRLVQLPVGGRTVTVLGSGNPLTNDRLDEQGNAALAMNLAGARSSVVWLIPDLPEPGSTRARSWQDLVPLGVWLFVLQLAVAVVLVALWRMRRMGPVVAEALPVVVRSAETVEGRARLYRAHRARGSAAEALRAGARDRLVPLLGLPRGAAQDPSMAQEIVSAVARRTQWDERVIGGALYGPEPVDDVQLVGLTDFLDDLERQVRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X8U3</accession>
    <name>A0A1H5X8U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipid kinase, YegS/Rv2252/BmrU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07860">
        <property type="protein sequence ID" value="SEG07860"/>
        <property type="gene ID" value="SAMN04489712_103130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG07860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="32292" checksum="54BE12E38E88FF06" modified="2017-01-18" version="1">MRSFTAVVNPSAGGPGSGSAAAATLLRTTRLLREAGAEVDVEYSRCLGHATELALTAAEDGRVVLAVGGDGMVGCVGGALAGKDATLGIVPAGRGNDFARQLGLPTDPAELAPLLLEGEPRAVDAIEANGVPVLGSVYAGVDALANHYANRSRLLRGSASYYVGGMRAVATWRPVRYRVTIDGVPHEWDGFTVVAANSGYYGFGRRIAPDARVDDGLLDVIILKRSPRLLFFQMMRELPTGAHVRRREVEVLRGREVRIEQLAPGERPLRYGADGELPGRLPVTARVMPGALRVLAPLPDSPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X9E7</accession>
    <name>A0A1H5X9E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_103147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08253">
        <property type="protein sequence ID" value="SEG08253"/>
        <property type="gene ID" value="SAMN04489712_103147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="174"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="278"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG08253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="541" mass="59029" checksum="13C56C42B0EE80CB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XCI4</accession>
    <name>A0A1H5XCI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09047">
        <property type="protein sequence ID" value="SEG09047"/>
        <property type="gene ID" value="SAMN04489712_103178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041669">
        <property type="entry name" value="TetR_C_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17918">
        <property type="entry name" value="TetR_C_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG09047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="180" mass="20158" checksum="43FFE2ECB8088CD8" modified="2017-01-18" version="1">MDAAARVLAERGYEGASTNRIAQAAGVGIGSLYQYFPNKDAIVVMVLDRFADRLADRLDAQIEATMAEPWPVAGRALLDAQIRLLEEDAGLLRVMVEQAPRLGPFDKSLALQRRLTDLVRVYLLLNHEEFREDLDVEAALWILAEAVGMLSIRYVLDRPPISHERMVDELAELIIGYLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XHW0</accession>
    <name>A0A1H5XHW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11213">
        <property type="protein sequence ID" value="SEG11213"/>
        <property type="gene ID" value="SAMN04489712_103258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018775">
        <property type="entry name" value="RlaP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34817">
        <property type="entry name" value="PTHR34817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10127">
        <property type="entry name" value="RlaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG11213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="26571" checksum="602CED2CB8EC4632" modified="2017-01-18" version="1">MTVGEMSGVRLVREHTVLSVVAGSRAYGLDTDASDVDRRGVFLAPTPLFWRFDKPPTHVDGPEPEQFSWEFERFCTLALQANPTVLECLWSPLVEQVTDVGRELLAVREAFLSRHAHRTFTRYADSQFRKLEGDLRNRGEPRWKHVMHLLRLLASGRHLIEHGEPLVHVGDLRERLLAVRRGEVGWPAVERWRAELAGGMDAALAASPLPDEPDRRRVADLLYSVRRRSAANAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XIV5</accession>
    <name>A0A1H5XIV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3' terminal RNA ribose 2'-O-methyltransferase Hen1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_103263</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11330">
        <property type="protein sequence ID" value="SEG11330"/>
        <property type="gene ID" value="SAMN04489712_103263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024026">
        <property type="entry name" value="3'-RNA_MeTfrase_Hen1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024740">
        <property type="entry name" value="Hen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038546">
        <property type="entry name" value="Hen1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="PTHR21404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12623">
        <property type="entry name" value="Hen1_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04074">
        <property type="entry name" value="bacter_Hen1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hen1_L" evidence="9">
        <location>
            <begin position="9"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG11330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="497" mass="54475" checksum="11DC13482CCD5B80" modified="2017-01-18" version="1">MAVRNTGSVLLTITTTRSPEAPASDLGFLLHKHPDKVQTFGQAFGTAHVFYPEATGDRCTAALLLEVDPVRLVRTRGKDTPDFSLGQYVNDRPYAASSLLASAMAGVFRTALRGRCDARPELAATAIPLRIALPALPCRGGPGLAEQLFAPLGWRVEAVPVPLDPGFPEWGDSRYVALTLRGTLRLADALNQIYVLLPVLDHAKHYWMASDEVDKLIRAGEGWLAAHPARARIVRRYLANRRGLVRSALGRLAAAEDVPEDALDRDPIDEEPPVADPTSAEPAAEEAAEARAAAPPVPLAERRIRTVLEVLREEEAPRVIDLGCGSGKLLARLVTDPFFTRVAGTDVSYRAITMAHNALGRALPRRATAHDKPWEVFQGALTYADERFHGYDAAVLMEVVEHVDPPRLPAVEHVVFGDARPRVVVVTTPNAEYNVRYEGLAPGAMRHPDHRFEWTREEFRAWAGQVAEAHGYRVRYVPVGDEDPEVGPPTQMGVFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XPW5</accession>
    <name>A0A1H5XPW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13799">
        <property type="protein sequence ID" value="SEG13799"/>
        <property type="gene ID" value="SAMN04489712_103355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG13799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="22323" checksum="1CF576804D018926" modified="2017-01-18" version="1">MAISDRLVRYLGSTKNLVGSACGLAGLGLHAAGMTGSSWPFVVAGLYAAGALAAPPERVTLVVAGAEDEIERLRADLDRLVERVAAHAGRMPPPAMVRLKEIRDTLDDLLARPDPLAADPRARQELIRAVRTDLPAGFETYLNLPGWFAAGRGRTTRRTAADELVAQLDLIAEHVTELAGRLLEAEAQRMRDQTRRLRDRSRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y343</accession>
    <name>A0A1H5Y343_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG18117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG18117">
        <property type="protein sequence ID" value="SEG18117"/>
        <property type="gene ID" value="SAMN04489712_103522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG18117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7516" checksum="D77422478ECC2CAF" modified="2017-01-18" version="1" fragment="single">MRGMALLRGRPQWQYVRYMAKAGTFLGGRRRPAHSPALSWNDFLKGNTVMRKLVRNALVAGAATTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YSF3</accession>
    <name>A0A1H5YSF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26427">
        <property type="protein sequence ID" value="SEG26427"/>
        <property type="gene ID" value="SAMN04489712_104134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="32316" checksum="3CEA9276AB75F086" modified="2017-01-18" version="1">MISDDTHSACDQVRAWRRAAYTYLRRYAAIGWTMRLGEDGWNLTTPPALNDLPPSKRLRKHARQEAERLSLAHQYLLCPLTTATAVAAGAHLREDRHTHAQTQAGRPNVVDTAGITPPTPFGFVCWQDPCGIGYNLGGAPILACHWGRLPRQEGTWLAWWADGRATLHAIKTTDPAARQDKPWARAASTVGWWTHIGPLYYDYQQLLRPHDLSKAPGKTRHDKADQTDPSSEEGIAAPDVALIYTTVATWQLLNDSATVHLTEYPPSPAEATADLTAGLTPRPLTLAAFPNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZI1</accession>
    <name>A0A1H5YZI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipase_D-nuclease N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_104277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29673">
        <property type="protein sequence ID" value="SEG29673"/>
        <property type="gene ID" value="SAMN04489712_104277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="8">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG29673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="11491" checksum="A4911E0BD4464747" modified="2017-01-18" version="1">MLYVVLGLIIVGVWLFCLFDVLTTDETEVRLLPRFGWFLVVLLGFMPGAALWLLLGRPREAAGHPGAPWSPSGSPAAPRPPVPKGPDDDPEFLRSLDRRIRGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z0C6</accession>
    <name>A0A1H5Z0C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28906">
        <property type="protein sequence ID" value="SEG28906"/>
        <property type="gene ID" value="SAMN04489712_104243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG28906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="21760" checksum="F08EAC566CD4A3EF" modified="2017-01-18" version="1">MAADASTRPGRPGRRPGPTETREKILDCARRLFAEKGYDGASLRGIAREAGVDPALVHHFFGTKQGVFIEAMRFPIDPQAILSRVAGTRSRDELGVALAEVFLEIWEDPARRVPVLAMLRSAMTNEQVATMMRQFVSAALLGPVTEAFGIAPIRVEAAVGQLIGVAMLRYVLGVEPIASATRQELVELLAPTLQRHFDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z191</accession>
    <name>A0A1H5Z191_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="9" type="ORF">SAMN04489712_104264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29355">
        <property type="protein sequence ID" value="SEG29355"/>
        <property type="gene ID" value="SAMN04489712_104264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="4"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="221"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG29355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="310" mass="32521" checksum="B5F4543843C29F68" modified="2017-01-18" version="1">MTALRLGTRKSLMATTQSGHVADVLSRLTGHAVELVGVTTEGDVSRAHLAQMGGTGVFVSALRDTILSGEVDFAVHSLKDLPTGPAEGIALAAVYRRDDPRDALCGPAKLADLPHGARVGTGSPRRVAQLRALRRDLEVVPIRGNADTRLSKVTDGELDAIVLAYAGLGRIGRREAVAEVFDPDAMLPAPGQGALALECRADRADLIELLATVDDPATRAAVTAERTVLAVLEAGCSAPVGAYATVEDTTDVEQSLRLTACVVAVDGSRQVRLSASGHPERAEEVGRELAARLLAQGADQLMGERHIEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z3Y1</accession>
    <name>A0A1H5Z3Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31223">
        <property type="protein sequence ID" value="SEG31223"/>
        <property type="gene ID" value="SAMN04489712_104346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG31223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9474" checksum="E192ACFDB031B270" modified="2017-01-18" version="1">MAKALADPLVRVGSIHHIKPGSLYEAEVPGGIQLAVFTFSWMEPGPDPVNGPPNVVAMNLHVPATLLHIAHRELAQLNPCPQRARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z420</accession>
    <name>A0A1H5Z420_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30780">
        <property type="protein sequence ID" value="SEG30780"/>
        <property type="gene ID" value="SAMN04489712_104324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG30780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="401" mass="41192" checksum="C0DE30228AAFF93C" modified="2017-01-18" version="1">MSSSQPWPSGQPSPPTPQPPPADGSSARRPRVPKPVVAGLAVTLLVGAVIALGALWGDGPDEGAPAGAQTSSRPAAPRWTAKAAARLETLPALRYTGTFTSSGRRVQARLSVTRAGSAVGTLTWNGRQAQLVSVNGTTYLKGGPVFWASAAGPTARPEDFAGRWSKAPVTVLGFDVKTFLSPSSIAEKVHDSAAGDAPGRVGGRPAHRVETPLGVYWLSAAEPYELLRVEGASDAGFDVVTLPDAAGVLTELRTRVAALGGARDPGVRFEHGELKFVNCNENVSGCTVSLPVSTQTPAVADGSAGPGTGGGTSMRAVLTATISADGRALGSCTAVQPLGPARKATLSCTVTSAGWKAWMRRARDVPGRHEYTAQARVVAEAVSPGQVADLLRSVDRERAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZA02</accession>
    <name>A0A1H5ZA02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">SAMN04489712_104415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32555">
        <property type="protein sequence ID" value="SEG32555"/>
        <property type="gene ID" value="SAMN04489712_104415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG32555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="93" mass="10726" checksum="132836C1ADB4AC6E" modified="2017-01-18" version="1">MAEQAQAEGAKRPSRKIAEGLVVSDKMDKTVVVAVEDRVKHRKYHKIIRRTTRYKAHDEANECGVGDRVRLMETRPLSATKRWRVVEILEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZGV9</accession>
    <name>A0A1H5ZGV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34985">
        <property type="protein sequence ID" value="SEG34985"/>
        <property type="gene ID" value="SAMN04489712_104526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG34985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="51" mass="5485" checksum="D75794F4CE33FDFF" modified="2017-01-18" version="1">MGFALQYSIALAQAREMVGVAAALLLAALAAYAGWHVTDRLVALRQRPDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZHJ6</accession>
    <name>A0A1H5ZHJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_104536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35215">
        <property type="protein sequence ID" value="SEG35215"/>
        <property type="gene ID" value="SAMN04489712_104536"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="4"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG35215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="33934" checksum="D6A5ABB8E2CFEB35" modified="2017-01-18" version="1">MKLLVTGGAGFIGSVVTAQLLEAGHEVVVLDDLSTGHEDAVPEGATLVRGTMRERALDVLEGAGFDAVLHFAARSLVGESVQKPGLYWDRNLGESLALLDAMRQSGVARIVFSSTAATYGEPESTPILETDPTRPTNPYGASKLAIDTTLTEYARLFGFGAVSLRYFNVAGAYGRFGERHAVETHLIPNVLAVAAGTRDAVHVFGEDYPTSDGTCVRDYIHVVDLGVAHLLALEACAPGRHQIFNLGSGSGSSVREVVEVCREVTGHPIPVQAGPRRAGDPAVLVASSDKIRSELGWKPERDLRLMVSDAWTFLRSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1D9</accession>
    <name>A0A1H6A1D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42538">
        <property type="protein sequence ID" value="SEG42538"/>
        <property type="gene ID" value="SAMN04489712_105144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025341">
        <property type="entry name" value="DUF4247"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14042">
        <property type="entry name" value="DUF4247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG42538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="13826" checksum="7BB7E3920FEA1CF8" modified="2017-01-18" version="1">MKHFVGGGLLAVLGAIVLAGALVSGNTSPRGWIGSHYSKVGNGVYRAPGPPTAVAATLTRKFKPSDRAYDPAGVFLRYPNAVVAVLPDGKGSRVLIDDVDRGYRRHYSYIGSRWGGPSGRASVFRGGGPGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A4M2</accession>
    <name>A0A1H6A4M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42927">
        <property type="protein sequence ID" value="SEG42927"/>
        <property type="gene ID" value="SAMN04489712_105168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046095">
        <property type="entry name" value="DUF6113"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19608">
        <property type="entry name" value="DUF6113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG42927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="179" mass="17754" checksum="9D435726731AB3C4" modified="2017-01-18" version="1">MPLTKDGGASSPGDPPSDGPADRPPAAHPAGEGPAGDGGRGAGAGNERLRAFVTGAAYGMLALLGVVLGVVGSLHYGWTVGPVPLAAIVLVALNFGVLWLAGWGMRAKPGAAVPWVTWMAVVIAASSRRSEGDLLITGDLAGYLFIVGGMVAGGLAVALTRSAGVPGSWLLGPGVRDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AGG0</accession>
    <name>A0A1H6AGG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47320">
        <property type="protein sequence ID" value="SEG47320"/>
        <property type="gene ID" value="SAMN04489712_105414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG47320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="32594" checksum="383A71E00DD4F58F" modified="2017-01-18" version="1">MPPSKKGPTLRSQWLGKHLRELRESAGLTLRDAGDYVQRDQGAISRWETGIVPARVPDVLALLNLYGVHDPAIRNALEQLSRDIWQKGWWDDYARETKTRVIDLAWLESRARRTKMYKAVVLDGLLQTRDYAREIMTANRPDYSPAKLERWLEFRASRQRKLTDDDPLLLDVVLDEATLRRMVGGAKVMRAQFAHLEDLAERPNITIRVLPFDAGAHASPLGAFTIFEMPEPYPDASHIETEAGSIYLEAESVERFALTYDCLLNSALPPEQSLAFIRALAERLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5E6</accession>
    <name>A0A1H6B5E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclease-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55427">
        <property type="protein sequence ID" value="SEG55427"/>
        <property type="gene ID" value="SAMN04489712_106231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="NERD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG55427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="33975" checksum="26FC7A325D7A272A" modified="2017-01-18" version="1">MATTKRGETGQGHPSEQTLRGSKPRPSRSPRDLLNDPRLRRWIPRPPGGAPGGSPGTSPGKPPGKPRPPRSARDLRNDPRVRQWVPRVGVALLVGLVVTLMFSLKAGVLVAALLLAADTYRRSRTSSTVVAWQKSSAAERRTERQLRSLAKNGYRILHARAVPRDDEGVSDGKIDHLVVGPSGVYAIDSEKWDRRLPVRTLSHRKLFHGPFNKKDRLDEARWEARQASKKLTAEVGFEVPVQPSVAIYGPSIPWKVMRVRDVDVYAGNRARAYLRRRPKILTEADVQRIFQAAEAALPPKYPTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BI59</accession>
    <name>A0A1H6BI59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuA</name>
        <name evidence="5" type="ORF">SAMN04489712_107132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60451">
        <property type="protein sequence ID" value="SEG60451"/>
        <property type="gene ID" value="SAMN04489712_107132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG60451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="568" mass="63326" checksum="43F10D770591A7A7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BIX2</accession>
    <name>A0A1H6BIX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60584">
        <property type="protein sequence ID" value="SEG60584"/>
        <property type="gene ID" value="SAMN04489712_107141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG60584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="112" mass="11377" checksum="F811F26465175D54" modified="2017-01-18" version="1">MSEISAEDAKIITLARSSRARGGAAEGAAVRDETGRTYTATSVDLPSLKLSALQVAVAMAVSSGAEDLEAAALVTADEQVRDTDVAAVRDLGRKAPILLAAPDGSLRATLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKC9</accession>
    <name>A0A1H6BKC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EDD domain protein, DegV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60915">
        <property type="protein sequence ID" value="SEG60915"/>
        <property type="gene ID" value="SAMN04489712_107167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="29347" checksum="400BC0401E211D2E" modified="2017-01-18" version="1">MYSPSMGSAVAIVTDSSAYLPAELSERHGLITVPLQIAVGGTVRDETELTVEQTARALKEWRPVTTSRPAPERFAHAYKAAAGAGAAAIVSVHLSAAMSGTVEAARLAAEAAPVPVRVVDTGTIGMGLGFAALSAAATARQGGDAAAAAAAALRRAELSRSLFYVDTLEHLRRGGRIGGAAGLLGSALMVKPLLNIVDGRIAPLEKVRTASRALARMEELVVETAGDRPVDIGVQHLAAAGRAEALAARLRERIPGLQDVYVGEVGPVIGAHVGPGMLGVVVAPQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKU1</accession>
    <name>A0A1H6BKU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61085">
        <property type="protein sequence ID" value="SEG61085"/>
        <property type="gene ID" value="SAMN04489712_107182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="563"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG61085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="679" mass="73330" checksum="F99BD63684E39AB6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BP89</accession>
    <name>A0A1H6BP89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62255">
        <property type="protein sequence ID" value="SEG62255"/>
        <property type="gene ID" value="SAMN04489712_107284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG62255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="20375" checksum="2803AC0351C110A4" modified="2017-01-18" version="1">MNTPVAARDRILRATLRLIGEQGVGAVTNRAVAKAAGVSLGSLTYHFPSQTDLLRESLRAFVDTEIVRITGHVERLRGTGIVLDQVAEEVQKAIVDFAYGPEQIANLELHLHSARDPEVRDASARSIAAYDHLAAAVLTALGIPDAERHAPAVVAMLFGLAIRRLSLGDDSASGTADAFRLLLNGALPRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYV0</accession>
    <name>A0A1H6BYV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_108146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65889">
        <property type="protein sequence ID" value="SEG65889"/>
        <property type="gene ID" value="SAMN04489712_108146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG65889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="486" mass="48913" checksum="3F6F3C10218A0352" modified="2017-01-18" version="1">MATTAPAVSQRSGRPGGGRVMPQLLALAAAGMVVSVQQTLVIPLLPRMMTVFDVSVTAVTWVFTVSLLAGAVTTPLLARFGDMYGKKPMILVAIGLQVIGSVVCALSGSLGALIAGRALQGVSAAMIPLAIALIRDTFPRERVTTAIGVVSATMGVGGALGMIVTGLLAARTDSHHPVFWINAGLATAVLLLVMACARDVGGRAGGRPDVPGTLLLAGWLVCLLLAISQGNSWGWGSPGVLGLFTGAAVLCAVWTLVERRVRVPLVDVRLLVGGQSLSANAAALLLGFAMFTGFTLTAQFMQVPESTGYGMGGSVLDVGLLSLPSTVTMLAASLWTGRLALRIGAAFTLAAGALVTGLSFAWLAVFNDGPADMIVYGGIQGVGLGVAYAALGTLAVQHVPMDKSGIASGINSLVRVAGGSIGGAASASVVAAYTRPGAIAPELGGYVLCFVIAAVGAGLAAVVAVVHGLRHRPPGGVHVVEALETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7T5</accession>
    <name>A0A1H6C7T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68963">
        <property type="protein sequence ID" value="SEG68963"/>
        <property type="gene ID" value="SAMN04489712_10936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG68963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="28316" checksum="CCECEEB7631F500C" modified="2017-01-18" version="1">MDGTTALDTRARILETALDLFSGQGYQRTSMREIAERLGLTKAAVFYHFPSKAHLLAALSEPLTEDVEESIRQALDEAAVRPDPDRARWVMIEYVLDAYLRHRRLLRVLMHDLTLLAHDHAFQRFVGLIEQVHQIVAGPDPDLRRGVRAVQAIAMISDPVMFFPDVPDERIRAEILAGVRTLLAPAPDGPPSAGPPGPPGPPAPPPRPARRRAGRPSVMDGDKGAQARRMYAAGTHSVTEIAAALGVSRATVYRHLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C846</accession>
    <name>A0A1H6C846_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multisubunit sodium/proton antiporter, MrpA subunit /multisubunit sodium/proton antiporter, MrpB subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_10955</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69149">
        <property type="protein sequence ID" value="SEG69149"/>
        <property type="gene ID" value="SAMN04489712_10955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="875"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="9">
        <location>
            <begin position="122"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="11">
        <location>
            <begin position="623"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="10">
        <location>
            <begin position="817"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG69149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="961" mass="100932" checksum="7F0D95C5D2398D72" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C898</accession>
    <name>A0A1H6C898_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69199">
        <property type="protein sequence ID" value="SEG69199"/>
        <property type="gene ID" value="SAMN04489712_10960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG69199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1194" mass="128172" checksum="AFFD67A767F3509A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAE6</accession>
    <name>A0A1H6CAE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69941">
        <property type="protein sequence ID" value="SEG69941"/>
        <property type="gene ID" value="SAMN04489712_109128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="523"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG69941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="720" mass="79410" checksum="209C134C4576E82C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CBX7</accession>
    <name>A0A1H6CBX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70500">
        <property type="protein sequence ID" value="SEG70500"/>
        <property type="gene ID" value="SAMN04489712_109175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
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        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="335"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG70500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="432" mass="46537" checksum="61074CF8D362F0BB" modified="2017-01-18" version="1">MDGDVGIIERIEASGRAAVRGLGLYLMSMVVGLLLFCLMVNSITMIGMGLGLFLVPVIGAKSRRYANKYRELTGRWTGTRIESPYLPEPPHRPGLTGWWNRTVHTLSDPATWRDLAWMVTDPLVACFTALLPISLIGMGIHGILLAAGLWVPIHELGGTQWYTFVPVSDWPTAITAGVVGLLYIGLGLKIARPLLAVHGRWAHQLLAPTEKARLALRVQRLTQTRSDAVDSQAAELRRIERDLHDGAQARLVAMGMSLGAIEHLLDRDPDKARLLLAEARQNSAKALSELRDLVRGIHPPVLADRGLVDAVRALALDHPLPVEVAAELPGRLEPPVESAAYFAVAEILTNAAKHSGARQVWVDVRHEDGMLRISVTDDGQGGAMASGGGLRGIERRIGTFDGVLAVSSPPGGPTIVTLELPCALSSPRISPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CE32</accession>
    <name>A0A1H6CE32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71132">
        <property type="protein sequence ID" value="SEG71132"/>
        <property type="gene ID" value="SAMN04489712_109244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="112" mass="12186" checksum="1E9F9FE8A22A7F7B" modified="2017-01-18" version="1">MRTSAAELTDGLMEMDGPPPPEGLAEAAHAEAPAVTDTAPDTAPIGRIEDEFPGWGVWRSDTGRWWAFRTAARPLTIEQIRAGCRLIVQADTVDRLRAAILDEIDCTRRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEX2</accession>
    <name>A0A1H6CEX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_109218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70896">
        <property type="protein sequence ID" value="SEG70896"/>
        <property type="gene ID" value="SAMN04489712_109218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="405"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG70896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="451" mass="49681" checksum="C7CB7BA643BA3BEF" modified="2017-01-18" version="1">MAFPAGFRWGVATAAYQIEGGVAEDGRGVSVWDTFCREPGRVRDGHTGDVACDHYHRWPEDLALLAGLGVDAYRFSIAWPRVQPDGRGPANPKGLDFYERLVDGLLERGITPFPTLFHWDLPQALEDAGGWLSREVAHRFADYAALVAGRLADRVDTWITLNEPVVVTAYGYAFGVYAPGRALLLDALPTAHHQLLGHGLAVDALRDQGARRVGLANHYSPAWAQDESSAADRRAAATFDLFMNRLFTEPVLLAQYPDLSVLGGPDPSSHVRDGDLAAIGAPIDFLGVNYYQPTRLRAPAPGDPLPFEIVPVEEYPVTGMGWPVVPDALLSLLRTLNETYSTSLPPVHITENGCSYDDRPGPSGTVDDPARIAFLGAHLSSIHRAVDEGIDVRGYFVWSLMDNFEWSEGYHPRFGLVHIDYETQRRTPKSSYAWYRDFIARSRSDGEAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJE0</accession>
    <name>A0A1H6CJE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gas vesicle protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72877">
        <property type="protein sequence ID" value="SEG72877"/>
        <property type="gene ID" value="SAMN04489712_11045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007804">
        <property type="entry name" value="Gas-vesicle_GvpG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05120">
        <property type="entry name" value="GvpG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG72877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="9118" checksum="8ECC619A852A81CC" modified="2017-01-18" version="1">MNLLSPLWKFPFLPVQGLVKIAELLQEEADRRTRQPAALRQRLEELQEARASGLISEEEEARATEELFGEVFGVPPTTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMP4</accession>
    <name>A0A1H6CMP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74309">
        <property type="protein sequence ID" value="SEG74309"/>
        <property type="gene ID" value="SAMN04489712_110212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="110" mass="12201" checksum="EF71D540DA6932A9" modified="2017-01-18" version="1">MDEALRAVADPTRRAILMLVRDEEVSAGVIAGHFPGISRPAVSQHLGILVAAGLVTVRRAGNRRYYRLRREGLAEAATFMETMWSAPLARLKEAAEREERARTDDEEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSJ1</accession>
    <name>A0A1H6CSJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75386">
        <property type="protein sequence ID" value="SEG75386"/>
        <property type="gene ID" value="SAMN04489712_11130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG75386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="35690" checksum="72C7AE77C58C3C70" modified="2017-01-18" version="1">MLETSARLLRLLSLLQSRRDWTGAELAERLDVGLRTIRRDIDRLRDLGYPVDATPGVAGGYRLGAGAALPPLLLDDEEAVATAISLRAAATGPVAGLAEPAVRALAKLEQVLPSRLRHRVTALQAATVPLTGPAGGDEAVDPGLLAAMAAACRDHRRLRLRYRGRDGSTTLRTLEPHRLVHTPRRWYLLAWDVDREDWRTFRVDRFDGPPGPPGARFTARTPPDEDVAGYVSRSISSAPYRYRARVLMHGPIEEVGRHASPTAGRLEAVDADTCILHTGSDSLEELAIYISAKGFDFEVLDPPELTGVLRAMSDRLRRAANASRPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CXB7</accession>
    <name>A0A1H6CXB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77145">
        <property type="protein sequence ID" value="SEG77145"/>
        <property type="gene ID" value="SAMN04489712_111255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="7354" checksum="EF8504E8302FD107" modified="2017-01-18" version="1">MRTEPERGEPQRVDSTESEGMSAARPSPAEGRISGRAAESTRPDWDYGMTGNTAHRPEEFNPDDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZS6</accession>
    <name>A0A1H6CZS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv2161c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78367">
        <property type="protein sequence ID" value="SEG78367"/>
        <property type="gene ID" value="SAMN04489712_11268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="284" mass="30716" checksum="E0DC03B7C5F165EE" modified="2017-01-18" version="1">MRHGIVLFTSDRGITPAAAAQAAEAAGFNTFYVPEHTHIPVRRDAAHPVTGDGALPDDRYMRTLDPWVSLASAASVTSRIRLATAVALPVESDPITLAKTIATLDHLSGGRVTLGAGFGWNTDELADHQVPADRRRTVLREYVEAMRALWTQEEASYSGEFVSFGASWAWPKPVQPHLPLLIGAGGGPKTLAWIAANADGWMTTPTERDITSKAQALHRAWTDAGRAGRPEISVLISARPSPEQIDDWERAGVTELIWGLPDRAADEVVAFIDRHARRLGLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1I8</accession>
    <name>A0A1H6D1I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system, OmpR family, response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_112172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79130">
        <property type="protein sequence ID" value="SEG79130"/>
        <property type="gene ID" value="SAMN04489712_112172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="150"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG79130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="27566" checksum="D4D43B3158912A42" modified="2017-01-18" version="1">MMDGGAEALTEHTTRRQAQEGAGTRLLVVEDDANILELLAGSLRFAGFDVVTATSGATAVEAALRHRPDLIVLDVMLPDFDGFAVVRRLRSGGTHTPVLFLTARDAVADRVTGLTIGGDDYVTKPFSLEEVIARIHAVLRRARGGVPEPSPRMAFADIELDEDSHEVWRGGRPIALSPTEFKLLRYFMANAGRVLSKAQILDHVWNYDFRGDAGIVESYVSALRRKVDNTEPRLIHTLRGVGYVLRPPQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2E9</accession>
    <name>A0A1H6D2E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79539">
        <property type="protein sequence ID" value="SEG79539"/>
        <property type="gene ID" value="SAMN04489712_112232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="149" mass="16860" checksum="1A20FB545AD5DE73" modified="2017-01-18" version="1">MGDEPHAEVARVWPRDGLIRVEGGWHLVKARSRDDWRVELIWRAHRNQRLILPVDAGPDGFVFAVPLRELATPWLRAAGPDARQVWDLHLVRARDGLRARVGRHLDDIPNKAGIMVYPAQRIDAGGPALVRPFYTPANHLAVRCRKLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2U2</accession>
    <name>A0A1H6D2U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79095">
        <property type="protein sequence ID" value="SEG79095"/>
        <property type="gene ID" value="SAMN04489712_112167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="65" mass="6872" checksum="8368A1C8842E4FDB" modified="2017-01-18" version="1">MTEERRPEQSTSLADRRAEAGAPVDSGAEPDIAEEWEPGPTDPPNAEADTPGGEAEGYTPHTRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4F4</accession>
    <name>A0A1H6D4F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolases family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_112228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79516">
        <property type="protein sequence ID" value="SEG79516"/>
        <property type="gene ID" value="SAMN04489712_112228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295497" evidence="6">
        <location>
            <begin position="36"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG79516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="495" mass="52803" checksum="5BB53639CAB60FE1" modified="2017-01-18" version="1">MTPVRRRAVGRSPGSGAPAALSGVLVLLLAGTACSAGGTPVSSAEVVRPTPASPAATAPRPVATASATPTPRPPAVPRPVGPVLRGNFPDPDILRDGDTYYAYATNGRGHNVPVAMAGSVHGPWIPQSADSLPRLGAWAEPGYTWAPEVVRRPDGVFVLYYTAASRRTGDQCIGVATASTPRGPFQPVGDRPLVCSARGDAIDAAFFRDTDGEPYLLYRADQAGPRPTAIFVRPLGDRWLGFKGAATRILTWDDSDPILVEAPALVRRGGHYVLFYSSGVFYSEEYRTRYATATRLTGPYRRAPGTLLSTDAYDREVIGPGGADIVQDEAGDHIVFHGITASSGNQRVTRSMYVAALGWDGRRPVVRGVPQRYEAEHADAVAGKSVLRPRASGDRAIDLYRGPGSKLEMKVFAPEAGVYTARLKYRLKWPRPVRAVLAVPDAPGTAGLSEVTLPYGGSPVSWPVAKTYLTLRQGWNTVSLQGLTAAVEVDRLEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D603</accession>
    <name>A0A1H6D603_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PD-(D/E)XK nuclease superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80760">
        <property type="protein sequence ID" value="SEG80760"/>
        <property type="gene ID" value="SAMN04489712_113147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="297"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="595" mass="64539" checksum="230075F95FA81C55" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6T4</accession>
    <name>A0A1H6D6T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-methylcrotonyl-CoA carboxylase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80503">
        <property type="protein sequence ID" value="SEG80503"/>
        <property type="gene ID" value="SAMN04489712_11394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="280"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG80503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="534" mass="57441" checksum="F415662248718969" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8E4</accession>
    <name>A0A1H6D8E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type phosphate transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81384">
        <property type="protein sequence ID" value="SEG81384"/>
        <property type="gene ID" value="SAMN04489712_11443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="333"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="617" mass="67464" checksum="7044C826BC38E577" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8S8</accession>
    <name>A0A1H6D8S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sirohydrochlorin ferrochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81538">
        <property type="protein sequence ID" value="SEG81538"/>
        <property type="gene ID" value="SAMN04489712_11480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG81538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="297" mass="30609" checksum="1E84B85D83273610" modified="2017-01-18" version="1">MTPATLLAVAHGTHDPAGPATVRALLDRVRALRPGLRVAEAYAELASPSLEEAVRQTRGPVVAVPLLLARGYHALIDIPGRLQEACGSRVVTVARPLGPHPLLSEALADRLAAACLIGPSSVPDGDSQDRPEHPFAAMPGGPGRLGPGRSLPRPARPGIAGASLAGMGLAGVDAVVLGAAGSSDPAGVADVRAAARLLTRRLRRPVRHGFVAAGEPGLAEAVARLREHGAERVAVAAYLLAPGFFHDRMSGAGADLVSPPLGAHDAVARLVLRRFDEARARTGGWRSPREMAGRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9Q5</accession>
    <name>A0A1H6D9Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81928">
        <property type="protein sequence ID" value="SEG81928"/>
        <property type="gene ID" value="SAMN04489712_114174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="146" mass="16381" checksum="570F804CB609E8C8" modified="2017-01-18" version="1">MTSRPVSAQRLSDLARLRRVRDRIDREYAQPLNVEALARGVNMSAGHLSREFRLAYGESPYSYLMTRRIERAMALLRRGDLSVTEVCFTVGCSSLGTFSTRFTELVGMPPSAYRRRAASATAGIPSCVAKQVTRPVRNREARVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9S2</accession>
    <name>A0A1H6D9S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_114171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81912">
        <property type="protein sequence ID" value="SEG81912"/>
        <property type="gene ID" value="SAMN04489712_114171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="4">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG81912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="20927" checksum="86A02857A7E024DE" modified="2017-01-18" version="1">MNQSHLTYLSSPAWAEALRTEVLPWLRQAADLGDDVLEIGPGPGLTTDLLLELTAASAGKVTAVEIDPVLAGRLRTRLGDGSAEVIHGDALDVPLEPGRFSAATCFSMLHHMPSPDAQDRLFARLYEVLRPGATLLGIDSVDSDLIRRGHLDDTYVPVDPDTLPGRLRAAGFSEPTVSRTGGYLFRFTARKPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DB92</accession>
    <name>A0A1H6DB92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_11570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82717">
        <property type="protein sequence ID" value="SEG82717"/>
        <property type="gene ID" value="SAMN04489712_11570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295705" description="Peptidoglycan glycosyltransferase" evidence="9">
        <location>
            <begin position="33"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="665"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="695"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG82717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="748" mass="80743" checksum="DE3E44469AB321FB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBD3</accession>
    <name>A0A1H6DBD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82549">
        <property type="protein sequence ID" value="SEG82549"/>
        <property type="gene ID" value="SAMN04489712_11542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="24395" checksum="469014582FDB17E5" modified="2017-01-18" version="1">MDSLIIPRRFNGPPDSGNGGYAAGRLAAGHGQDALRDGVTVILRNPLPLDTPLSVSPDAVRLRLYDGERLLAEALPGRVEASPIPAVSHETAVAATAGYPGRDNDNGTPFAYCFVCGPGRPDGLRLAPGPVAADTVAAPWTPDASLAPDPALIWAVLDCPGGWSGDLLARPALLGTMTARVLDLPEIGEPCVVLGRLLRRDGRKMFATTTLYGQDGRLLAQADQTWIEFTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DD09</accession>
    <name>A0A1H6DD09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11549</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82595">
        <property type="protein sequence ID" value="SEG82595"/>
        <property type="gene ID" value="SAMN04489712_11549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG82595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="314" mass="34686" checksum="26FBF8B2281E21A3" modified="2017-01-18" version="1">MDARFDGRRRPGAAAKESDHATDPATEAFVAHRNLLFTVAYEMLGSAADAEDVLQETWLRWVKVDLGQVRDQRAYLVRITTRQSLNRLRTMTRRKEAYVGPWLPEPLLTAPDVVEDVELAESMSMALMLILETLSPTERAVFVLREVFDVGYDEIAAAVDKSPAAVRQIAHRARRHVEARRPREVVSPGEIRAALESFQRALETGDPQDLLDVLAPEVVLMSDGGGVKQAALRPIIGAEKVARMFFGGLGKVKGTLTGEPTVVNGNPALLVRLDGELDGVLAVRVEDARITGLYYVRNPEKLSRVESETPLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE46</accession>
    <name>A0A1H6DE46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_115118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82983">
        <property type="protein sequence ID" value="SEG82983"/>
        <property type="gene ID" value="SAMN04489712_115118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="10836" checksum="E06D9F8800F0BC15" modified="2017-01-18" version="1">MSKILERRRARRTALLNNDGERHPLQNTLTLTAFVLGMCALVLGGIPPTHLFGAVAGVIGLPIALYAQLVSATTGERFFNVIAMIGSFVGAAFALRHGGFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFX0</accession>
    <name>A0A1H6DFX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_116141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84091">
        <property type="protein sequence ID" value="SEG84091"/>
        <property type="gene ID" value="SAMN04489712_116141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG84091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="384" mass="40736" checksum="4DB585FF5FB31B35" modified="2017-01-18" version="1">MSFIESEERRALRAAVAELGAKYGPSYYVAKAKAGEKTDELWNEAAALGYLGVNVPEEYGGGGGGIGDLAAVCEELAAAGCPLLLMVVSPAICATIIARSGTEGQKKHWLPRFADGSVKMAFAITEPDAGSNAHCITTQARRDGDGWVLSGQKTFISGVDEADAVLFVSRTEDQKGNLRPSLFIVPTDAPGFTWTPIEMEIVSPEKQFICHLDEVRLPYEALVGEEDGGLLQLFAGLNPERIMATAMGAGIGRLALDKAVSYARERQVFKVPIGAHQGLAHPLAAAKVELELARLMGQKAAWLYDSGDDMGAGEAANMAKYAAAEAAVHCVDQAIQTHGGNGLTTEYGVGMLAGVVRLMRIAPVSREMILNFVAQHSLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGP3</accession>
    <name>A0A1H6DGP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4097 and DUF4098 domain-containing protein YvlB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84548">
        <property type="protein sequence ID" value="SEG84548"/>
        <property type="gene ID" value="SAMN04489712_11723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="29803" checksum="5770F5489B6505E3" modified="2017-01-18" version="1">MPTFDTPEPITAIIDILAGRVWIRAGDRADTVVEVRPSDASEDADVQAAEQTLVEYADGRLSVRAPKHKFRSLLGRAPSIDVTIELPSDSRVDARAAADVRGEGRLGESTFHTAAGSVRLDQTGRLKLRAGAGDVWVGRSAGHLNVTTTSGKIRIGEVDGIAVAKTSNGDITIGEVTGDVRLNTANGDITVDRALATVVAKTAYGSVRIGEVVRGSVVLETNFGQVELGVREGTAAWLDVGSRHGGVRSGLDAADGPEQAEETVKVHARTGYGDIVIHRSRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHY8</accession>
    <name>A0A1H6DHY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_117125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85057">
        <property type="protein sequence ID" value="SEG85057"/>
        <property type="gene ID" value="SAMN04489712_117125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="118"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="226"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG85057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="39815" checksum="F1DB4A9B842E9DB7" modified="2017-01-18" version="1">MDFRDSPEEAAFRERLRSWLAERAGTFPTSGDDYWRRQGEWHRALHAAGFFGLSWPRAYGGQELPPVYDVILDEELARAGAPPRPSLGYLVQGLGRHGSEELRRRFLPGMINGTERWCQGFSEPGAGSDLAALTTTATRDGDEYVVHGHKIWTSYSDVADWCLLLARTDPDAPRHQGISAFVVSMHQPGIEQRPLKMINGVTTEFGQVLFEGARVPADQMVGAPGEGWRLAMTVVGHEREPSTLGFSARYGKTVRTLAARVEGAPPAELAWAAVQTEMLRLHVRRRLSEQLDGVSHGPEGSLDKLLMTWVEQDVGHAALAMGGTRDPELLSTYLYSRAQSVMGGTSQIQKNIIASRILGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DI49</accession>
    <name>A0A1H6DI49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucoamylase (Glucan-1,4-alpha-glucosidase), GH15 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84872">
        <property type="protein sequence ID" value="SEG84872"/>
        <property type="gene ID" value="SAMN04489712_11783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="3">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="2">
        <location>
            <begin position="215"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG84872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="608" mass="68252" checksum="299F5FB1A7E949C4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJK0</accession>
    <name>A0A1H6DJK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Raffinose/stachyose/melibiose transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85577">
        <property type="protein sequence ID" value="SEG85577"/>
        <property type="gene ID" value="SAMN04489712_11837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295940" evidence="1">
        <location>
            <begin position="29"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="44366" checksum="259C207178EC60FE" modified="2017-01-18" version="1">MRRTHRLTAVMVAGVTLAAGACSSGTNASGGSDTLRITAVATDRAGTEAVLKAFQAKNPGVKLTTSYSDTDQYQGTLRTQLSSGTAPDVFFAWPGNGNPAAIEVLAPTGYLADLSGRSWTARIPAGIKPVTQVAGKTYIVPMTFVGIGGLYNQQAMNEIGAKPPTTWSQLLAFCDTAKAKGKVAFALGNQTDWVTQLVNYALVPTTVYASDQSFDQRMKAGAATFAGSGWKTALTKYLEMNERGCFSKDPLGTSFETSVAQLAKGDAVAAIQVTSTLNQVKSQAPQGTGFGLFPVPATDDSDETRMPGAAGGAFALNAKAKNPELASKFIDFLATPEAMNAYAGATGNLPSIPNDQFKHDPALQPLVDFQKAGKTVHFMDQLWPNPKVQQTHFTGVQNLFAGKADPDTVLRQMDEAYQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLP1</accession>
    <name>A0A1H6DLP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, luciferase family (Includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86220">
        <property type="protein sequence ID" value="SEG86220"/>
        <property type="gene ID" value="SAMN04489712_11924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="314" mass="33522" checksum="33CB4230FDCA4FB5" modified="2017-01-18" version="1">MRLCANWLPLSPDLTREVAARCEATGLWGIGVGDSPNYGELYSACTDALGATSSLVVSTSVTNPVTRHWSVHASAVRALASAHPGRFRLGFGRGDSAVHTFGLRPASLADLEHFGRSVADSARAAGVGPFLLVAASGPATARIAGRVADGVIAGVGGDPVALRTIRERAHAARADDAPFEVWASVRIAIGRDDDEVRDLRRRLIPRAVSASHFAFASTFEGKNVPEAYADVLAERYATYDYGSHGRSGATSNATMFADRPDIEDYLLNRFAVVGRPDDCRARLEELSTHVDGIYLSLLFEDALTQIDRIGVMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLX2</accession>
    <name>A0A1H6DLX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_11978</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86417">
        <property type="protein sequence ID" value="SEG86417"/>
        <property type="gene ID" value="SAMN04489712_11978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296106" evidence="9">
        <location>
            <begin position="27"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="68"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="284"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="518"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="317"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="550"/>
            <end position="557"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG86417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="747" mass="76516" checksum="323A36CF239CF317" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DM76</accession>
    <name>A0A1H6DM76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85826">
        <property type="protein sequence ID" value="SEG85826"/>
        <property type="gene ID" value="SAMN04489712_11887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="454"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="550" mass="58529" checksum="069A6951F9F33A4D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNA3</accession>
    <name>A0A1H6DNA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86186">
        <property type="protein sequence ID" value="SEG86186"/>
        <property type="gene ID" value="SAMN04489712_11911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="294" mass="31205" checksum="5910C2786281D2E4" modified="2017-01-18" version="1">MDLRTLRYLVAVVDEGGMTQAARVLFVSQPSLSLAMRRLEDELGVRLFDRSGRGAVPTADGARLVGLARQVIAEADGARERVRQVTNLEVGRLVVATSTTLAVHPLTPLIAALRGRHPGLEVHVRDASTAAGALGMVRSGEAELGVVDVMPPDAGWGWCDLGAEEIVLVASPEFAAGLTEPVARARVAGLDLGVVPSDLDSASAAATAVASMAGRVRAQCAHRAMLWELVRDGTVATFVGRDTAKTVMPWASLRSLDPPLWRDAYLVWREQALSPAGVALVELARGRDELPSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNE6</accession>
    <name>A0A1H6DNE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86867">
        <property type="protein sequence ID" value="SEG86867"/>
        <property type="gene ID" value="SAMN04489712_12022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="87"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="172" mass="19426" checksum="AC4D407D1ADBB77E" modified="2017-01-18" version="1">MNVQDMMVFRDAGSRTVDKYLMSYEAHVIAVRRHPAVLLQPVAETLGGLLVAALVHTYTGLALLWIPWLLLVGRLVWKLIVWSMEFFLVTEHRVMMVSGVLNRKVAMMPLGKVEDIKLDRSPVGRVLGYGEFIIESAGDKQALRNVTYMPYPEQLYVEISSMVFGAEDESPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNY2</accession>
    <name>A0A1H6DNY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein SAMN04489712_12049</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86999">
        <property type="protein sequence ID" value="SEG86999"/>
        <property type="gene ID" value="SAMN04489712_12049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="124" mass="13552" checksum="5BDBE222972B8730" modified="2017-01-18" version="1">MGSGNRQALGRRGEETAARYLSDRLGWTIVDRNWRCREGELDIVAYDGSRHVVCEVKTRTGTAFGTPAEAITPAKAARLRRLAGRWAAQYGVPAATVRIDVIGLVVAARGERTGFDLEHLRGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP89</accession>
    <name>A0A1H6DP89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_119118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86583">
        <property type="protein sequence ID" value="SEG86583"/>
        <property type="gene ID" value="SAMN04489712_119118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="35" mass="3855" checksum="8A57FB7ED9510239" modified="2017-01-18" version="1">MTRLSRALTPDGESYDLFAEVLDVLAKRGMDVTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DS86</accession>
    <name>A0A1H6DS86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88080">
        <property type="protein sequence ID" value="SEG88080"/>
        <property type="gene ID" value="SAMN04489712_12171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="198"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG88080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="42331" checksum="B89F4354303AA7D3" modified="2017-01-18" version="1">MKATTWAGRNKVEVRDVPDPSILNSRDAIVRITSTAICGSDLHLLDGYVPTMQDGDVMGHEFMGEVVEVGPGVEAGRLRVGDRVVVPFPIACGVCAACAAELYSCCENSNPNAGVAEKMFGHPTAGIFGYSHLTGGFAGGQAEYARVPFADFGPLKVDGDLSDEQVLFLSDILPTGYMGAQMCDIRPTDVVAVWGAGPVGQLAMDSARLLGAAQVIAIDREPYRLRMAEDAGHTTVDFSEVDIRSALLELTGGRGPDKCIDAVGLEATHGSAHIHVYDRIKQAVRAETDRPHALRQAILACRNGGVVSVIGVYTGLVDKFPAGAWMNRSLTLRTGQCHVQRYMKPLLKRIERRELDPTRIITHTLPLDEAPHGYNIFKRKRDNCEKIVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWS0</accession>
    <name>A0A1H6DWS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89708">
        <property type="protein sequence ID" value="SEG89708"/>
        <property type="gene ID" value="SAMN04489712_12436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="9624" checksum="1B20A0E60F80795A" modified="2017-01-18" version="1">MIAADDARRQALHGLAGPLRGQGYAVAVESHHLTVTDDEGRRVEVWAQKRASDGGRLWFVRAGGFPICEADRPMDAIVAVKGALAEGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWX5</accession>
    <name>A0A1H6DWX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KDO2-lipid IV(A) lauroyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89223">
        <property type="protein sequence ID" value="SEG89223"/>
        <property type="gene ID" value="SAMN04489712_12345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG89223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="34124" checksum="49653B85B97D037E" modified="2017-01-18" version="1">MTPTPVGRLRDEAADAAYALGWTVVRKMPERAARLLFTALADQTWQRRGGGVRQLERNLCRVLGKDSVDDEVRVLSKRVMRSYMRYWLEVFRLPEFGRGRVLRDMLAEGHEKVFAALDSGRGVVLALPHMGNYEQAGAWVALHGYPLTTVAERLRPESLFDRFVAFRRSLGMEVLPLGDGTGATVFGTLARRLRAGRLVCLVADRDLTEGGIEVDFFGRLARMPGGPAALAVQTGAALYPVTLWYEGDKWAARVHEEIVVPEAGGRKDKIRVMTQRLALVFQEGIAEHPEDWHMLQRVWVEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXB2</accession>
    <name>A0A1H6DXB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89839">
        <property type="protein sequence ID" value="SEG89839"/>
        <property type="gene ID" value="SAMN04489712_12485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="49" mass="5182" checksum="4CC33CC00E05B029" modified="2017-01-18" version="1">MLAQGTPLHVVSEILGHASIAITKDVYGHLMVDDKRAAAESMTNALFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYA7</accession>
    <name>A0A1H6DYA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">SAMN04489712_12446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89736">
        <property type="protein sequence ID" value="SEG89736"/>
        <property type="gene ID" value="SAMN04489712_12446"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="94"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="121"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG89736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="178" mass="19031" checksum="24090C90250CDBD2" modified="2017-01-18" version="1">MNDREELLQEIKKKAVVHGEFTLSSGRRATWYVDLRRVTLDGRAAPLVGRVMLDLTADLAYDAVGGLTLGADPVAAAMLHAAHAQGRRLDAFVVRKADKTHGLQRRVEGPDVAGRRVLAVEDTSTTGGSVLTAVQALREAGAEVVGVATIVERGAAERIRAEGLDYRSAYQVSDLGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYN4</accession>
    <name>A0A1H6DYN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Amino acid/amide ABC transporter membrane protein 2, HAAT family /amino acid/amide ABC transporter ATP-binding protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_12645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SEG90462"/>
        <property type="gene ID" value="SAMN04489712_12645"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="LivM-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="345"/>
            <end position="591"/>
        </location>
    </feature>
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        <location>
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            <end position="320"/>
        </location>
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    <feature type="binding site" evidence="8">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG90462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="593" mass="63566" checksum="CB90BAF1E71A55BF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYN9</accession>
    <name>A0A1H6DYN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty-acyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90447">
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    </dbReference>
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        <property type="entry name" value="AMP-bd_C"/>
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        <property type="entry name" value="AMP-dep_Synth/Lig"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="415"/>
        </location>
    </feature>
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        <location>
            <begin position="424"/>
            <end position="502"/>
        </location>
    </feature>
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            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="521" mass="57758" checksum="A90C5CC16701646F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E231</accession>
    <name>A0A1H6E231_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91441">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005840">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="145"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="32284" checksum="99B89156FC9BBA5D" modified="2017-01-18" version="1">MRAYRHPDDLRALQGLVRRVWSPGCQYHVGDLAWQRRQHLGREGEWPTALWEQDGVVVGWGWAELPGFLNLLVDPARPNLIDAVLEWFDGVATAGPLTVVALQHDTRLVEALERHGYSRKQTEVYSQYMYRPLTGLPEPGSPPGFTVRPVSGEADAARRAAVHQAAWHPSRVTEDSYRTVMAAWPYRADLDWVVEAPDGRFASYCLIWYDGHNRAGEIEPVGTDPQFRRMGLARAACLAALRALRDLGADKAVVYPTRGHPASQGAYPLYRDLGFIPHARTHTYEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2K1</accession>
    <name>A0A1H6E2K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-phenylpropionate/cinnamic acid dioxygenase, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91938">
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        <property type="gene ID" value="SAMN04489712_13135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="179" mass="20384" checksum="6EF265760FB9748A" modified="2017-01-18" version="1">MTTATQRPTPAPPQVQAEAALFLAVEAELIDDRRYAEWLDVVTDDFTYTVPVPVTPDNPFAPHHDPEALLLDESKDSIRHLWFRRLEADMHEFAWGENPPPQLRHFVTNVRAYLTGDPDELAVRSNVLVVGRRQSDQPKYLSAERFDTLRRGAAGLLLARRHAVLDQTVIDFPQPRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E527</accession>
    <name>A0A1H6E527_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92114">
        <property type="protein sequence ID" value="SEG92114"/>
        <property type="gene ID" value="SAMN04489712_13229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VanY" evidence="2">
        <location>
            <begin position="240"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="39156" checksum="E3D90196DBE38935" modified="2017-01-18" version="1">MLIPRSAALGAAFLAVTLLALVYAPQGWVHRAAAWSVADPVDDLRREADKARDDLEKATKQWESRKKELAESQTKLQDTLKELGKAEAELNRIRAPLARLANTVYQHPGAAGSLGILNNGGSDAALRMTADLTHIARGQEALIRRADELQERYERLASTAQELQSRNAVEQTRLQRQIQTLKQRSAELTAQLTTMLDKLEVSREKRLLMSCSADLVADARKYPNGLVPSKYLCDLPQKGEQLRADAARGFYKLNVAYKKQFGRDICVTDSYRSLADQQRVYYQRPGFAAVPGRSNHGLGTAVDLCGGVQTSGSTQFNWMEANSRKYGWFHPSWAYSNPFEPWHWEYGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E541</accession>
    <name>A0A1H6E541_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate lyase subunit beta / citryl-CoA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92810">
        <property type="protein sequence ID" value="SEG92810"/>
        <property type="gene ID" value="SAMN04489712_13537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="11"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="30142" checksum="B4C79D68E0D2A904" modified="2017-01-18" version="1">MPDPVGNAVWRSLLYVPANRDRFVRSAVSSSADAVILDLEDAVPAEHKAAAREQLSGAVAALRQGTAAVLVRVNRPWTAMIPDLEAAVQAGVDGVIIPKSDDAGMIRTVDQALCELEGDTAGAPTKVIPLIESARGVRRVDEIVDASTRVIAASTGIGDLCLDLRASPDSTAVTHAFTEVVQATKAAGRTPLGLAGLIVSFTDIDQFRALAATSRAIGSTGASCIHPRQIGTLNEVFGPSPDEIDGARRVVSAYEEAAAEGRGSVMLGDIFIDNANYRYAKELLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E656</accession>
    <name>A0A1H6E656_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93268">
        <property type="protein sequence ID" value="SEG93268"/>
        <property type="gene ID" value="SAMN04489712_1383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="33965" checksum="431E3745821EF9E5" modified="2017-01-18" version="1">MTGRGESVVEVEGPWTHRAVSAGGTRFHVVEAGEGPLVLLLHGFPEFWWSWRHQLVSLPAAGFRAAAVDLRGYGGSDKPPRGYDLVTLAGDAAGLVRALGEANATVVGHDWGGLLAWTMAVYRPKVVQRLVTVSAPHPLRLRQAVRTGLRSQAWASRHSLEFQVPMWPERRLVRDDAALVGRMLHEWSGPDWPDEVTERRIRQAIQIPGVAHSALEYHRWLIRSLARPDGIRYARRMRAPIQVPTLQLHGALDTFTLPGSAQGSGRYVAAPYHWELITGAGHFPHQERPEDFDAAFLGWLQDPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6F9</accession>
    <name>A0A1H6E6F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93388">
        <property type="protein sequence ID" value="SEG93388"/>
        <property type="gene ID" value="SAMN04489712_13840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032025">
        <property type="entry name" value="DUF5063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038312">
        <property type="entry name" value="DUF5063_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16702">
        <property type="entry name" value="DUF5063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="20644" checksum="404E6085DA52B2ED" modified="2017-01-18" version="1">MSDIPPRSNSPEEWETLAERVTLHVRNYLSGLEAVARGEAATHTLPVLLLEVSQVILAGAQLGASADVIPPDNWEPELGPDPDLDEVRQGLAQRLAPVDEYVEVFDPYNDPEPTAYRLSDDLVDVASDLVHGLRHYERGRPLEALWWWQYSYFNHWGNHAGAALRALYAVIAGARLNVAEEAAVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7X2</accession>
    <name>A0A1H6E7X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92955">
        <property type="protein sequence ID" value="SEG92955"/>
        <property type="gene ID" value="SAMN04489712_13627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="448"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="544" mass="59337" checksum="9EBC4C0193520504" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E812</accession>
    <name>A0A1H6E812_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93860">
        <property type="protein sequence ID" value="SEG93860"/>
        <property type="gene ID" value="SAMN04489712_14111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="154" mass="16872" checksum="63D3358EE2C59D65" modified="2017-01-18" version="1">MNPSSERSALPLVITGCSRRKRNTQVPLPALDLYEGGCIPELRRRLGHIPAFRARLRILSAEHGLIGADEPLLPYDRKLTPSRAAELRPLVTEHLRREFAATGTPPAVLLAAGPDYQSLVVGLLGSIDGLRLQTVDDTRHWAAISSVLDGWGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9Y1</accession>
    <name>A0A1H6E9Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93736">
        <property type="protein sequence ID" value="SEG93736"/>
        <property type="gene ID" value="SAMN04489712_14025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="292" mass="32394" checksum="CE12CAC00B0F7A04" modified="2017-01-18" version="1">MSSAETSAEEQVVTYERRGTVAFVTLNRPEYRNAQNSKVTYALDAAFTRAVDDDEVKVIVLAGNGKHFCAGHDIGSPGRDIDESFERKAVIWWDHTRKQGVDRRLAREAEVYLGMCRRWREIPKPMIAMVQGACIAGGLMLAWSCDFIVASEDAFFADPVVRMGIPGVEYFAHPWVMNPRAAREFLYTGDRVPARRAHELGMVNHVVPHQELEQATLAIAERISQMPSFGLALTKKAINQAEDLQGMRAGMDSVFGLHHAAHAHNAEVGVDSLAGMDARSMRDSSARPENAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAV7</accession>
    <name>A0A1H6EAV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000054">
        <property type="protein sequence ID" value="SEG94877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94877">
        <property type="protein sequence ID" value="SEG94877"/>
        <property type="gene ID" value="SAMN04489712_1541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296724" evidence="1">
        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="66"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="153" mass="16329" checksum="5E38DADDD4838A77" modified="2017-01-18" version="1">MISKRIAGGVLIAGTAAAVIGCAPATERPTTPSTAAVASEHPSETLKPLIQQALPNVQGKTFTSAIVTFPPDARAVPHRHGNAFVYAYVLKGTVRSRLEGQPMRTYHQGENWTEQPGAHHVATENVSNTEPAELLVVFISTTGEQLKTDDPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAX3</accession>
    <name>A0A1H6EAX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-(Hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000047">
        <property type="protein sequence ID" value="SEG94391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94391">
        <property type="protein sequence ID" value="SEG94391"/>
        <property type="gene ID" value="SAMN04489712_1476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG94391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="368" mass="37390" checksum="439B30E9090887D9" modified="2017-01-18" version="1">MARTAMAAVHDGRGTTLDIREVWVADPGPGEVLVRMGASGVCGSDRHVIDGEWHLPTPTVLGHEGAGTVEAVGPGVTDVAPGDSVILSWYYPCRRCRACAAGKAWACTGTRSGECLLPDGTTRLSDERGVVYPYLAVGTMSEYAVVPESAAVRVPSELPMDVASLIGCSITTGVGAVTNNARVPAGASAVVVGCGGVGLAVVMGLVLAGAHPIIAVDTSEEKLAAARSFGATHTVQAGPGTDVAAAVADLTGGGADYAFEVIGRVETIETLPSLLATAGVGVLVGLPPEGARAGIDVLELAEAGKTLIGSNYGGAVPGLDFPRLAGLYLAGRLPLDSLISHRIRLEEVNEAFAAMRAGTRTRSVIVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S517</accession>
    <name>A0A1H5S517_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45709">
        <property type="protein sequence ID" value="SEF45709"/>
        <property type="gene ID" value="SAMN04489712_10184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF45709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="73" mass="7483" checksum="868F4B9D0BCDCB9E" modified="2017-01-18" version="1">MLIECDTCRVRACGDCVVTALLQIGGPGRAAGPGPAAAPPPDQVIHLDDGELAALDLLAELGMVPPLRHERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SHB6</accession>
    <name>A0A1H5SHB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Purine catabolism regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50022">
        <property type="protein sequence ID" value="SEF50022"/>
        <property type="gene ID" value="SAMN04489712_101211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="3">
        <location>
            <begin position="38"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="5">
        <location>
            <begin position="308"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="4">
        <location>
            <begin position="523"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF50022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="587" mass="62855" checksum="29441B90F4E9CC88" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SLU9</accession>
    <name>A0A1H5SLU9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ORF">SAMN04489712_101264</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51404">
        <property type="protein sequence ID" value="SEF51404"/>
        <property type="gene ID" value="SAMN04489712_101264"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="188"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEF51404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="363" mass="38045" checksum="B457FF66D5DD9051" modified="2017-01-18" version="1">MRVVLAGGGTAGHIEPALALADALRREDPSVGITCLGTERGLETRLVPQRGYDLALIPPVPLPRTLTPRLLTVPGRLRGAINAAAAVLDRVQADVLVGFGGYVATPGYLAARKRRVPIIVHEANPRPGLANRLGARFTEDVAVSHADSPLPHARFVGIPLRRDIATLDRLAVGDKARSYFGLLPDLPTLLIFGGSQGARSLNRAAVAAAPAFRAAGIQVLHIVGPKNTEEPEPAAGGPQYVTLPYCDRMDLAYAAADMAMCRSGAMTCAELAAVGLPAAYVPLPHGNGEQRLNAEPIVAAGGGLLVDDAELSPEWIHANLLPVLGDPARVAQMSEAAARMGRRDADVALARLVHEVVAGTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T1Q2</accession>
    <name>A0A1H5T1Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56753">
        <property type="protein sequence ID" value="SEF56753"/>
        <property type="gene ID" value="SAMN04489712_101449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF56753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="27651" checksum="AED919D51F14436A" modified="2017-01-18" version="1">MSRTRWVQPPQAQDSPTKSVPVLPALEVVYLTDPDLLAEVLPPPLTPPAAPRVHVRITDIDLTFGEYRHKELVGYFAVDAEHEGRPGEYPLLIPIDLEAAVAISRERFGEPKKLADLELTRDGDRVTGRITRHGVTFVEIDGHVVEKLPTPEPYPARQFWFKFLPAVSGSGFDAGPLLVRMEQVRKPESVERVDGKLVLRDLPDCPVVDLPVREIVSIQWVRRASDNTTEVVGPVDPEAFAPFAAARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TDJ7</accession>
    <name>A0A1H5TDJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60932">
        <property type="protein sequence ID" value="SEF60932"/>
        <property type="gene ID" value="SAMN04489712_101579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF60932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="319" mass="35281" checksum="EB1DFA1988D41CA6" modified="2017-01-18" version="1">MIEVTDIHKTFTVRTRTGRLRRRRTTVRAVDGISFTVAPGEFVGYLGPNGAGKSTTIKMLTGILSPGSGTVRVAGLDPSRRRTALARRIGVVFGQRTTLWWDLPLRDSLTLIRHLYRVEAGAHRRRLAELTELLDLGPFLSTPVRQLSLGQRMRGDLAAALLHDPPILVLDEPTIGLDVVSKATVRGFLERVNTERGTTILLTTHDLGDIERLCRRVMIIDHGRLAYDGDLDRLRAAVAADRVLVVDLERPAPPVRLAGVVVERVEGPRQWLRVPREMNAAAVVAALADRYPIADIALREPGIEEVVTRLYRDGGRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TGS4</accession>
    <name>A0A1H5TGS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61950">
        <property type="protein sequence ID" value="SEF61950"/>
        <property type="gene ID" value="SAMN04489712_101612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009285031" evidence="2">
        <location>
            <begin position="30"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="253"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF61950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="452" mass="47926" checksum="83500E9AA9874CC3" modified="2017-01-18" version="1">MPEVRRRDLLAGAAAFAGFATVGLSPAAAAAATRQRPGASRPPSLTMGDRAVVARVDARRALRHLKVLSDEIGWRIAGTPSEHRAARYIAGVLRDLDYDVRLQPFPVADKYLAEMKARGGVHWQCSAAPRGAVASAKGRVVDLGAATEVTEDVAGRLVLFTRVTGSETAQAKAAAAKGAAAVLIANVPSPSFPERKAAAFTPSLSEDVAVPVLGLAQYHGEQLRGKVRELSLTVTRYTGLTSYNVLAERRATLPNPEGKAVIISAHYDSVPGSPGANDDGSGTVLCLELARVLRRLPTQQTVRIALWGSEEYGLIGARHYVKELTDEQAAQISGCFQNDMVATSHPPAGTYWLLSVDGAANTTTSAVAAAAARLGYQGQTKGPTARGSSDHEAFFERGIAAGNFSWRGEEAPSQLEPIYHTPEDTIAKNISLQRLQVSLELIGCAAYDVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TUI5</accession>
    <name>A0A1H5TUI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylation protein EvaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66495">
        <property type="protein sequence ID" value="SEF66495"/>
        <property type="gene ID" value="SAMN04489712_101753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013630">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038576">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013691">
        <property type="entry name" value="MeTrfase_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08421">
        <property type="entry name" value="Methyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08484">
        <property type="entry name" value="Methyltransf_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_13" evidence="1">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_14" evidence="2">
        <location>
            <begin position="241"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF66495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="44270" checksum="FAF14296CB662693" modified="2017-01-18" version="1">MCRVCGGAVHEFFDFGRQPLSDAFLDPAGVGHEYFFRLAVGICESCTMTQLIDEVARDRMFHEAYPYHSSGSVRMRRHFEETAQLLLDSHLTGPDPFIVEVGCNDGVMLKTIDKAGVRHLGVEPSGGVAQLACEQGVRVRVDFFEESVASAIVAEDGPADVIYAANTMCHIPYIGSVFRGVDALLAPDGVLVFEDPYLGDILRRNTFDQIYDEHFFFFTVRSVRNAASRFGFELVDVERLPVHGGELRYTIARAGRREPSPAVEEVAAEELELGLAAPADFDGFAASVNRIRDDLMGLLRGLRAEGKRVVGYGATAKSATVTNFCGIGPELVSFVCDATPAKNGRLMPGSHIPVRPPEALADPYPDYAVLFAWNHAEEIMAKERAFHEAGGRWILYVPEVHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V9B8</accession>
    <name>A0A1H5V9B8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">SAMN04489712_102193</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83047">
        <property type="protein sequence ID" value="SEF83047"/>
        <property type="gene ID" value="SAMN04489712_102193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEF83047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="83" mass="9489" checksum="CD82FE5B3D7C539A" modified="2017-01-18" version="1">MDWRHIAACRDVDPELFFPIGNTGPALLQIEEAKQVCRRCEVTQACLRWALESGQEAGVWGGMSEDERRALKRRNARARARAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VDN9</accession>
    <name>A0A1H5VDN9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_102249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84597">
        <property type="protein sequence ID" value="SEF84597"/>
        <property type="gene ID" value="SAMN04489712_102249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="161"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF84597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="33298" checksum="5974CF29DE328FC0" modified="2017-01-18" version="1">MQTPLEWLALARGGLDRVTDRRGDDAWIAERWADPATRVLVVERGQALIRTLTSDGGAPELILLPPGEAPEGDRYLLGVDDGTAYFAVSAALPAIEGTDTTDLRRIGAVLGDLDSALLTQAVALQNWHAAHTHCPRCGVPTDPAKAGHTRICPADGAEQFPRLDPAVIMLVQDGRDRVLLGRAPVWPQPMMSVLAGFVEPGESLEQAVAREVHEEVGLVVGDIAYLGSQPWPLPQSLMLGFFCRAAGDQDLRLDREEIAEARWFTRAELVEAAERRDVLLPGRVSIARQLIERWYGGRLPGSWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VF71</accession>
    <name>A0A1H5VF71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylyltransferase and sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85147">
        <property type="protein sequence ID" value="SEF85147"/>
        <property type="gene ID" value="SAMN04489712_102268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="301"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF85147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="42280" checksum="9C1E1107FFE97157" modified="2017-01-18" version="1">MSLPPLVEPAAELTREEVNRYSRHLIIPDVGMAGQKRLKNAKVLCVGAGGLGSPALMYLAAAGVGTLGIIDFDVVDESNLQRQVIHRQSSLGMPKAESAAATVREINPLIDVVVHNVALDRDNVLEIFSGYDLILDGTDNFATRYMVNDAAVLLGKPYVWGSIYRFDGQASVFWAEHGPCYRCLYPEPPPPGMVPSCAEGGVLGVLCASIGSIQVNEAIKLLAGIGEPLVGRLMIYDALEMSYRTVKVRKDPECALCGKNPTITELMPDYEAFCGTVSEEASEAAKDSTISVHELKAMQDRGEDVFLVDVREPNEYEIVSIPGATLIPKGEFLNGSALERLPQDKKIVLHCKSGVRSAEALAVVKNAGFTDAVHVGGGVLAWVNQIDPSLPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VGN2</accession>
    <name>A0A1H5VGN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85677">
        <property type="protein sequence ID" value="SEF85677"/>
        <property type="gene ID" value="SAMN04489712_102289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009287263" evidence="1">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF85677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="15539" checksum="3F1B9A843BEBF392" modified="2017-01-18" version="1">MQTKILAALAAAALTPVAALATTGTAHAAPRTQPVGAWDVTVTIDGQSHPSRVSFTSAGKVCLATQVSSGRGHWWRTGARTFRYVIKEEFQPIPGLPGHVLIDQQAVQPGETYTSTGTSRVYDTAGNLISSPVADITATRAAAVPDPGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VVJ4</accession>
    <name>A0A1H5VVJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90587">
        <property type="protein sequence ID" value="SEF90587"/>
        <property type="gene ID" value="SAMN04489712_102454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF90587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="240" mass="25542" checksum="314E0B393C3D1443" modified="2017-01-18" version="1">MQLPRVIIAAVFFVIGLMLVVPMLLRDSSSSSSASETPSPGNGPTALTTESPSGSPSRSASPTRTPTRSPSPTRTPTPTRPPAAPTVTASPSAPSQPLRVAVGRVDCPGRTVEVTVRNTGTTTQDYTVETNDGTAPKGDRIAAGQTRTTQLTLREDRRTRVTVTWRNEPVEQATRTADCRRSPVGAPTDEELPHTGADSGVLWARAITGIAALITGVIVFWYGGIWPRRREQVFAKKDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VWV4</accession>
    <name>A0A1H5VWV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpA</name>
        <name evidence="14" type="ORF">SAMN04489712_102497</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91734">
        <property type="protein sequence ID" value="SEF91734"/>
        <property type="gene ID" value="SAMN04489712_102497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="13">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="11">
        <location>
            <begin position="153"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="12">
        <location>
            <begin position="383"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEF91734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="546" mass="59319" checksum="F12241667C895AF6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W0K6</accession>
    <name>A0A1H5W0K6_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Probable phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptosporangiales</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF92818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="242" mass="26316" checksum="139DD9FA23B81496" modified="2017-01-18" version="1">MVRLPAVNPADESAERVYRQSRFAPPPGATEVLLVRHGASQAFRPGEPFPLVDGQGDPELAPEGREQAVQVCRRLAGEHIDAVYVSSLRRTSQTAEPLARALGLVSRVEPDLREVHLGSWEGGLFRVKVAENDPVALRLFAEERWDVIPGAEEAEAFARRVRQVIDRLAAAHAGQRLAVFTHGAFIAQALALAARSRPFAFLGADNASISHLVVLDGRWTVRRYNDTAHIDGALEASAAPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W432</accession>
    <name>A0A1H5W432_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102581</name>
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        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
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        <property type="gene ID" value="SAMN04489712_102581"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF94249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="25039" checksum="09C6B55A232EDEB3" modified="2017-01-18" version="1">MELVAGTHNTPETLDTALQGVSRLHITVTAGLAEVGPELVQRAVAAGVQRFTVLWGGWVGPVEQAVADSGVEWTRLEAQEFMSNTLTWAESIRAEGVVREPYDLPNALVHEADIGAVAAVALLEDGHAGRSYNLTGPELLTPSDRIAILSRVIGRDIAFEPITHEQAVDRLMATGVSRADAEYVVGWYAKPDDAATTVDDTVERVIGRPARTFTQWAEEHADRFKPGMISTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W526</accession>
    <name>A0A1H5W526_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94510">
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        <property type="gene ID" value="SAMN04489712_102589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009287899" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF94510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="43" mass="4465" checksum="81007044DFFF2B42" modified="2017-01-18" version="1">MRIAIAALVGVLLASGASFGVVQMANASQQDPVIEPLYNYGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WB77</accession>
    <name>A0A1H5WB77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96077">
        <property type="protein sequence ID" value="SEF96077"/>
        <property type="gene ID" value="SAMN04489712_102637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="38"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="184"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF96077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="27700" checksum="E8124BD330AE2954" modified="2017-01-18" version="1">MSEYPETPGAAPGGASRRRAGDPAAAAPGEQAATDPIRVLIVDDHALFRRGLEMVLADEDDIEVVGEGGDGNEAVEMARDLLPDVLLMDIRMPRRSGIEACLAIKESVPSAKIVMLTISDEDKDLFEAIKAGASGYLLKEISIDEVPQAVRAVHGGQSLISPSMASKLITEFASLAKRSEERQQQVPAPKLTDREMEVLRLVARGLGNREIAKELFISENTVKNHVRNILEKLQLHSRMEAVVYAVREKLLEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WBV7</accession>
    <name>A0A1H5WBV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_102664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97069">
        <property type="protein sequence ID" value="SEF97069"/>
        <property type="gene ID" value="SAMN04489712_102664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="152"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="269"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="379"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF97069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="461" mass="49224" checksum="04AAD98B1D3D8C96" modified="2017-01-18" version="1">MGDVAKIFKAYDIRGVVPEEFDEGIAEAVGAAFVRVTGAARVVTAHDMRPSSEPLAAAFARGATGQGADVVEAGLGSTDLLYYASGSLDLPGVMFTASHNPARYNGMKMCRAGARPIGRDTGLTEIRELVEAGVPAYDGPRGTVTRRDVLAGYAEHLHRLVDLRGIRPLKVAVDAGNGMAGHTVPAVFDRRPGSAQDDGPPIELVPLYFELDGTFPNHEANPIEPENLRDLQAAVRDSGADLGLAFDGDADRCFVVDERGEIVSPSAITALVAARELAKYPGAAVVHNLITSRAVPEIIAEHGGTPVRTRVGHSFIKQTMAETGAVFGGEHSAHFYFRDFWFADSGMLAALHVLAALGEQDEPLSKLLRDYDRYPASGEINSELADAAEQAAATERVRAAFADRPGVTIDGLDGLTVGTADWWFNLRPSNTEPLLRLNAEATDEETMAAVRDEVLAIVREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WYE3</accession>
    <name>A0A1H5WYE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04532">
        <property type="protein sequence ID" value="SEG04532"/>
        <property type="gene ID" value="SAMN04489712_10315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021487">
        <property type="entry name" value="DUF3140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630">
        <property type="entry name" value="PTHR40630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11338">
        <property type="entry name" value="DUF3140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG04532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="119" mass="13472" checksum="0E34BB86804D9E41" modified="2017-01-18" version="1">MSAEREEIRAQFRAAVNMTPGELARWLDGELSRSVGVTGEGGRKSGPEGTESVGHESGRRIVEILRTKAADLGDDDYAHMRKVVGYVRRHLAQRPKKEPIEDSRWRYSLMNWGHDPLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X5L8</accession>
    <name>A0A1H5X5L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07031">
        <property type="protein sequence ID" value="SEG07031"/>
        <property type="gene ID" value="SAMN04489712_10398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG07031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="299" mass="32655" checksum="49C2A48FDFEBA837" modified="2017-01-18" version="1">MESLSGRQRDGPAPRPAARRVGCGGRHGGRFRSRIPRAGPGPGPPAAVRPTPPRRARSGRPRMFPVRHSPAPRARRHRRATPPRFRAARWTRHLCPPGTHLGSSAVPDPPCTALPIRPRRPRGRRRYASSGCRRRMPPRRRHPTSPRRPRATPPLRRDGDADLGVAYLARHATPSPAAGPGITAARRRGVIVCSIRCAHERRGAPDRRTSGPVTLSDHFDRCDPRTRGGPRLRGSRTSASAGPARHGPAARRGRVTGDGPSTGRPGRDRSCDAAPRRATRTRRAGRRAGRRPGSRWSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XL49</accession>
    <name>A0A1H5XL49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, OmpR family, contains REC and winged-helix (WHTH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12160">
        <property type="protein sequence ID" value="SEG12160"/>
        <property type="gene ID" value="SAMN04489712_103293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG12160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="217" mass="23984" checksum="F1D0B48EE38E1578" modified="2017-01-18" version="1">MRVLIVEDERVLADAIATGLRRQAHAVDVAYDGAGALERTSVNEYDVVVLDRDLPKVHGDDVCRELVGRRYPARIIMLTASGELDDRVEGLTIGADDYLAKPFAFAELVARVQALGRRAAAPLPPVLERAGVTLDPARREVQRDGRPVELTRKEFAVLEVLLRADGAVVSSERLLEKAWDEHIDPFTNVVRVTMMTLRKKLGDPPLIETVPGVGYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XML9</accession>
    <name>A0A1H5XML9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12640">
        <property type="protein sequence ID" value="SEG12640"/>
        <property type="gene ID" value="SAMN04489712_103310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG12640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="11534" checksum="77B387743EC6AF87" modified="2017-01-18" version="1">MAWLLELVPPEYRRYGVFRRYPPTLVRMARQHVEACVTAAREGFRTARVDLGESVPPHGVEALLEVYRREGTRLAALAEAIKLVEAALREQSPSPSPGPSTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XT68</accession>
    <name>A0A1H5XT68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subtilase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14852">
        <property type="protein sequence ID" value="SEG14852"/>
        <property type="gene ID" value="SAMN04489712_103396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="131"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG14852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="40886" checksum="7E054026EDDD7B5A" modified="2017-01-18" version="1">MFDQEARLERMLARHTDAAVVEPMAGRPTVVRRDQILVATDDAAAVEDVVRRWYDSGHDEGGVYLMRLRPQARVDVCELATRLGGDGRGRGLAVAPNTVVYGQPMWWSGPAGRPRPAGPVPAPSAAAPPRRDVTVAVLDTGLSAHPWYEDTDWYAEQREEVAEVLDADLDFKLDAQAGHGTFIAGVVLRHAPSARIRARRVIGGDGVGDELGVVRALTWLADWGRADVVNLSLGCYTFDDRPSPVLARALAALGRDTVVVACAGNAAGDRPFWPAAFEPVIAVAALDGQERARFSNYGRWVDACAPGVDVASCYLDFDGSRPPMNGVDPDAFAGYATWSGTSFAAPAVAGTIAGTAAAEDLPAGAAAARVLDPAKARTLPGLGVVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y1D5</accession>
    <name>A0A1H5Y1D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid/cholesterol/gamma-HCH transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17814">
        <property type="protein sequence ID" value="SEG17814"/>
        <property type="gene ID" value="SAMN04489712_103510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="27232" checksum="D5D214A5E7A43F36" modified="2017-01-18" version="1">MTTPQYTLPGVGALRETGRLFALAGAVLGGMFRRPFQFRELVEQFWFIASVTILPTALVSIPFGAVIALQVGSLTQQLGAQSFTGAASVLAVIQQASPLIVALLISGAGGSAICADIGSRTIREEIDAMTVMGVSPIQRLIVPRVLACMGVAVLLNGLVSVVGVAGGYFFNVIMQDGTPGAYLASFSALAQLPDLYISEIKALIFGFIAGVVAAHRGLNPRGGPKGVGDAVNQSVVIAFLLLFFVNLVLTAIYLQVVPPKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YP22</accession>
    <name>A0A1H5YP22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25891">
        <property type="protein sequence ID" value="SEG25891"/>
        <property type="gene ID" value="SAMN04489712_104111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="2">
        <location>
            <begin position="137"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG25891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="43246" checksum="9C3CA37964D06472" modified="2017-01-18" version="1">MDLQALAASPVGTLVPIEGLDTRTGRTYKHKAFVPTALPHELVLEPSTYSAISDAVAEVVRLDEASKKLPSPSSLAQTTIRVEAVSTTALAGSRTSLIEVLKGEILPRYKRSPAAIEAINYIQAADHGLTWTKNEPISIGLINYLHKALLKDTPADTHAGTPRSTVTFIGDSPTLEESRFVPPPPEHLHDSLRSWIEWANKADQIPTLAKIALSHYQFETLHPFTEGNGRLGRLICTLQLARSRQITHPLLHLSTWMLSKKFQYHDHLLQCSKKGRFDEWIQFFCQAVQHRSRETTRKIDELIHWRREIVNELHRRGRRGVIHQIVKNLIGYPVVTPQMAAGQHSVSYQAANAAILHLEDMKILHEQTGGAYGRIFAAPQVLSIISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YQI2</accession>
    <name>A0A1H5YQI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_104127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26268">
        <property type="protein sequence ID" value="SEG26268"/>
        <property type="gene ID" value="SAMN04489712_104127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="94"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG26268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="29000" checksum="64616A4E308845C7" modified="2017-01-18" version="1">MGLLVLGAGIAGVTPQPRSGRPPSRLRLWIRGAASPARRKRLAGAVVAGLAVLLALRWPVAAVAVGAAGYVLPPMLSGREPQQRIARLEALAAWARRLAEVMGASRGLEQALADSARVAPQAIREPVGILADRLNNRANTEQALRAFADDLDDPIGDLIACALVLAAKRRGPGTREALSLLADAVEQEVIVRRQVEAERASLRTTLLVIVLSIGALSALFIMSQTLAAPYGTPLGQAVLGVVAGIYAVGLWWMRRLSALSTGARFLRGDRAEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YUB8</accession>
    <name>A0A1H5YUB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclease-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27588">
        <property type="protein sequence ID" value="SEG27588"/>
        <property type="gene ID" value="SAMN04489712_104186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="NERD" evidence="2">
        <location>
            <begin position="83"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG27588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="27283" checksum="590176984E40F12C" modified="2017-01-18" version="1">MPGRRAGGGASQAGASARARYRMLAGEYRRQRIAVRLVLTAAVAVIVLGLAGWRASVTAAALAFVAHLAHTRYRPGPVTGWRRGALAERRTGRRLARLGRGYRVLHDRALPGTPATNLDHLVIGPTGVHAIVSRRWRPGTRLWADRRRMWAGRRPVTTLPVAAVRIARTVGELLGAELGQEVPVSAIVAVHGARLPDEGLEHRGAIFQQAARLPGFVEECPVVLTGAQVAAIAAAAERVLPPMLNAVAQGARGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZY24</accession>
    <name>A0A1H5ZY24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40356">
        <property type="protein sequence ID" value="SEG40356"/>
        <property type="gene ID" value="SAMN04489712_10529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="284"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG40356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="602" mass="65608" checksum="83178461838F73BF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A8D6</accession>
    <name>A0A1H6A8D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44307">
        <property type="protein sequence ID" value="SEG44307"/>
        <property type="gene ID" value="SAMN04489712_105245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="79" mass="9135" checksum="98D088CCA630C1AA" modified="2017-01-18" version="1">MTALSTARREIGHLAGVVKSDVPLPADRRLRCHRCRKLNRSATWRQWLTLKAGRKPKHWCGARMTLVDISTWTARQVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABA3</accession>
    <name>A0A1H6ABA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Magnesium chelatase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46039">
        <property type="protein sequence ID" value="SEG46039"/>
        <property type="gene ID" value="SAMN04489712_105339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="174"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG46039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="474" mass="51617" checksum="7F27278251FA8B20" modified="2017-01-18" version="1">MPSTTNESAPADTTVGALRADGHLQRPVKAEIRHNLLERLRSGRSRFPGIVGFDDTVLPHLERALLAGHDMVLLGERGQGKTRLIRTLVGLLDEWTPVVAGCEINDHPYAPVCVRCRRLAAELGEELPVGWRHRDERFGEKLATPDTSVGDLIGDVDPIKVAEGRTLGDPETVHFGLVPRTNRGIFAINELPDLAERIQVALLNVLEERDVQIRGYALRLPLDVLLVASANPEDYTNRGRIITPLKDRFGAEIRTHYPLALEDELDLIRQEAALAELDAQVPDHLLEVVARFTRLVRDSNAVDTRSGVSARFAIAGAETIAAGAVRRAALTGEREAVARVCDLPAVVPTLMGKVEFEVSEEGREQEVLEHLLRRATAETYRRTLGAADLSGLLEKFDAGDSVESGELVPATELLRRIGQVPGLAKLVQRLGMSGESPGQAAAALEFALEGLFLTRRLSKDVSQGGADGTATYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABU7</accession>
    <name>A0A1H6ABU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46229">
        <property type="protein sequence ID" value="SEG46229"/>
        <property type="gene ID" value="SAMN04489712_105352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG46229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="437" mass="47099" checksum="06D0E7827D31B0C5" modified="2017-01-18" version="1">MQDGVAPRLAPLLTRILLGPEHSGDRDAQVAAAELPIRVRAWDGSSIGPDTAPTFVIRHRRALRRMLWKPGEMGLVRAYVAGELDIEGDIFAALGAVQRVMRHGDEPIRLGSDDKREIVRTAVMLGAVGPEPKPPPEEFPTGRHTDNPGLAGPFGESAAFFRLLLGDSLAYGCGDWEGARDLDEAQRAMREAVTSRLGLFPGARVLDLNCGWGAFAFHAATREPVRVVGLVRSRAQADHIRRRAAEEGLSDRVEPRLGDLTAAGDGPYDAIVGLGGADLGGGVGSAALPAARLYELLAPGGRLLVQQTLRRPGPHHVRRTFTTSYMFPEDGELRPLGEVVSLLEEAGLEVRGVTALREHYARTLRSWAAGLRRHWTEAGELASPGRARVWLLYLAASALACESGRIGVHEIYAVRRDRDGRAGESLVDALAVHGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJG0</accession>
    <name>A0A1H6AJG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISPR/Cas system CSM-associated protein Csm3, group 7 of RAMP superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48661">
        <property type="protein sequence ID" value="SEG48661"/>
        <property type="gene ID" value="SAMN04489712_105488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG48661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="589" mass="63587" checksum="F4C055AEECEF103D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJZ2</accession>
    <name>A0A1H6AJZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49059">
        <property type="protein sequence ID" value="SEG49059"/>
        <property type="gene ID" value="SAMN04489712_105512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG49059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="454" mass="46569" checksum="583C532AFD07F25E" modified="2017-01-18" version="1">MSCGLFTPGLCRGLLRDGLDTLAGSAFDAIVRSFISAANTLLEAFAKAFVAIPPIDLDSPGITGIYGTSLGLATVVAALLLLGQVIRTAVTQDGSALAQGVVGLIKAALAILLTVAITGTALRASDELTDYIVVRSFGSTRALTDKLAHLIVWNQTQGLAEASALLLILAVVGIVLTLVLWFELLLRNAAIAALVATSPIAAAGLVTESTRQWWTKTAVATAQLIVLKPVIALVFALGFGMTGQSKDIQGLLAGMLILLLAVFAWPAIARFFSFASAAVGGSTGFGALLGAAAGHTGGGSGRAPAGVEPDQFSREAEARTMATFGGGRGGGAVGPAALMAGVQTAQKVINSLGRGIDQTAAHAGMSGRPATYSAGFPTYPGRYRSGGHWPADHSDPPVTGEEQALRCRHDRVSAQRQLGASLASQAAGTGGRTGHAFESGDRERRRVRTMSRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWU2</accession>
    <name>A0A1H6AWU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate cyclase, class 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52515">
        <property type="protein sequence ID" value="SEG52515"/>
        <property type="gene ID" value="SAMN04489712_10636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00318">
        <property type="entry name" value="cyaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="178" mass="19937" checksum="5CD83D2F357369F4" modified="2017-01-18" version="1">MREVEVKFRVRDVESLLVALKAQGIELGEPTHQDDQAYAPVGWRFGDSKLGVSFVRLRTVDGRDFFALKQPGENAQACLEYETEVADREQMHQAIVNMGFYATVRVAKTRRTATVGDITICVDDLEGVGTFLELERMIPDDASAIETQRQLAAFVARLGIDAEHTEETYDSLVRAVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYH4</accession>
    <name>A0A1H6AYH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyisoprenoid-binding protein YceI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53404">
        <property type="protein sequence ID" value="SEG53404"/>
        <property type="gene ID" value="SAMN04489712_10690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="20064" checksum="B7600F31B6B1F6EE" modified="2017-01-18" version="1">MSTLATDLTTLTGDYTIDPAHTRIGFVARHAMVTKVRGAFNEFEGGAHIDGANPEASTAKVTIKAASIDTRNAQRDEHLRSNDFLAMDEYPEITFVSTAVRRTGEDTFDLTGDLTIKGVTNPVTVPFTYEGLATDPFGNVRAGFEGSVTINRKDYGVTWNAALETGGVLVSEKITLEFEVSAIKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B141</accession>
    <name>A0A1H6B141_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54322">
        <property type="protein sequence ID" value="SEG54322"/>
        <property type="gene ID" value="SAMN04489712_106150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="2">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="3">
        <location>
            <begin position="247"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG54322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="407" mass="45375" checksum="56326C59C984EB2B" modified="2017-01-18" version="1">MTTAEISGPDWSTRETPRTPEEWIARAGEVAAILASDAVERDRAAATPYAEVRLLKDSGLVTLLGPAEHGGGGQNWPTAYRVVREVAKADGSIGQLLGYHYLWNWAARLVGTREQWEHVEAEAARNRWFFGGAVNPRDDDVVIRDEGDTLVFNGRKSFSTGSKVSDVTVLEGVLEGTDKHVFAIVPSGDPGLTFHDDWDNIGQRLTESGSVTISDVRVPWRDAAGYVDKEFQPRVYNTLNVPTIQLVFVNFYLGIARGALETAIAYTRSRTRPWLHGGHERAVDEPYIIDIYGDLSAALWSAEALADQVAEEGLWFHEHPDEVTERLRGEHEVRVAAAKVQATEVALEVAGRIFEATGARSTTSREGLDRFWRNVRTHTLHDPVAYKRREIGVYLLQDKLPEPTWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B272</accession>
    <name>A0A1H6B272_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54909">
        <property type="protein sequence ID" value="SEG54909"/>
        <property type="gene ID" value="SAMN04489712_106188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG54909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="27344" checksum="D789F6763FEC252F" modified="2017-01-18" version="1">MSVSLPKALSDRTLAALNEVEELTTVRERDLTSPMSPAPVGALKVLRGERIAKVVYIGLTVEAIGMDSHMIFAFTGADSAVPHFTLDSVMAGGYLAYHIDLVPRAELASHLEYTNTAFHPLTPVFEEIRERFGPSTASIGPRQYAMMSPWMLVNRATEEQFQQLDGYLDRYFEHWRGLVDKGLPDDVLATLADTDLADRDARNRANLFNPEVDPVWGNVARLLGDEQTDALRAELLTNDLPAGEASDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B296</accession>
    <name>A0A1H6B296_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54939">
        <property type="protein sequence ID" value="SEG54939"/>
        <property type="gene ID" value="SAMN04489712_106190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG54939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="257" mass="26724" checksum="24F9765E8ADDF04A" modified="2017-01-18" version="1">MTAVVVTGGTRGIGLGLAREFVARDVKVAICGRSQESVDKALGELGEGVVGAVCDMADRAQVQALWDTAVEAFGRIDHWINNAGVSTARRPLTEVPPEQLETVVAANLLGVLHGSAVAVAGMTAQGGGTVWNMAGLGSDGRTVPGLIAYGATKRGSDYLTTGLAKEVKGGPVKVAHLSPGMVVTDLLIQDYSPEELEKAKKVFNILADRVETVTPWLAAKVLAGTKNGGTVAWLTTPKIAGRFATAAFRKRDLFSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6U2</accession>
    <name>A0A1H6B6U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56561">
        <property type="protein sequence ID" value="SEG56561"/>
        <property type="gene ID" value="SAMN04489712_106321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="29649" checksum="090C2EF56E2E49C1" modified="2017-01-18" version="1">MTDETPDQAPPKIDTSVPHSARIWNYWLGGKDNYEVDRIAGDQYMAVFPQIVELARSGRHFLARAIHYLAGEAKVRQFLDIGTGLPTVDNTHEVAQRIAPDARIVYVDNDPLVLAHARALLTSTPEGATTYLDADVRDPEKIIERAKDLLDFSQPVAIMLMGVLGHVTDEEAVSIVRRLAAELPSGGYMAFYEATDTDQSFQEAQSGYDDTGATPYRLRSREVIERYFEGLELVEPGLVQGPQWRPEVEPLEHKDHPTLAAVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6Y7</accession>
    <name>A0A1H6B6Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56380">
        <property type="protein sequence ID" value="SEG56380"/>
        <property type="gene ID" value="SAMN04489712_106308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="26987" checksum="76FD3EA554B1A99D" modified="2017-01-18" version="1">MADGRRSLAEILDGLCLRPVGRPDPYTNTELARLVNERGGDITDGYISHLRKGHRDNPTLQTLQDLAAALGVCPAVFVGGRLERLDEECPRRSFSAKLRHLFTAVYPPERGPYTPEDVAAAISAGGRYGTISASHIRDLLNPGPGSLPNPRLKHILGLADHFGLADEHGPQAAYFLDDRLAATIDAELADLMALRDAGVVDFVTRVAAHAPAWSPELRRQAVRAITQALESGDAGTGWVFPLTGERLSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BEI0</accession>
    <name>A0A1H6BEI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58656">
        <property type="protein sequence ID" value="SEG58656"/>
        <property type="gene ID" value="SAMN04489712_1079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG58656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="376" mass="38166" checksum="F80B452BF8FAC9F7" modified="2017-01-18" version="1">MLVAPDKFKGSLSAPEVARRLAAGLRRARPAVPIVELPIADGGDGTAEAAIAAGWRRVEVKVAGPTGQPVTAALAMNGGTAVVEMAEASGLRLLPGGRPAPLTATSLGTGQLVAHAVRLGARRVVLGLGGSACTDGGAGLVQGLGGRLLDALGKELPPGGAALRGLHALDLRAMTDLSKVEVIIAGDVDNPLLGRTGAAAVYGPQKGAGREEVRVLEAGLRRWADLAEAASRRPARDLAGAGAAGGVGFAALTFLGARMQPGSSFMLDLLGFADRARGARLVITGEGSLDTQTLRGKAPIGVARAAARAGVPVIAVAGRRGLTGEQLRRARIQAAYALTDIEPDVERCIRQAGLLLEQLTVAIADEWLPPGRAAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNX9</accession>
    <name>A0A1H6BNX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kynurenine formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62391">
        <property type="protein sequence ID" value="SEG62391"/>
        <property type="gene ID" value="SAMN04489712_107293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG62391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="23574" checksum="045410ADEB301E03" modified="2017-01-18" version="1">MTPELVDLSVPIVTGMPVYPGDPAVVVAQALTVTNSGVNVNRLHMGSQSGTHVDAPYHIDDHLPRLEHLPLERFTGPAVVADARGRPPRTPLGPQVLPEGLGPGVVLLVATGWSALWGSPDYLAHPYLAPETCTAIVAAGVRTVGIDALSVDRTPAGDEEFSLAAHRVLGEAHGVIAENLTGLDRLLEAQRAGRAIEVSLFPIRLSGDGAPVRAVARVAPPPHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BV46</accession>
    <name>A0A1H6BV46_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xylB</name>
        <name evidence="8" type="ORF">SAMN04489712_10838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64601">
        <property type="protein sequence ID" value="SEG64601"/>
        <property type="gene ID" value="SAMN04489712_10838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="239"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG64601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="464" mass="47726" checksum="7EE85E7D13B7BA37" modified="2017-01-18" version="1">MTPTLVAGVDSSTQSCKVVVADAATGRIVRSGQAPHPDGTEADPAAWQEALHLALVRAGGLDGVAAIGVAGQQHGMVCLDEAGRVVRPALLWNDTRSADAARELTAELGGPDAWAKATGSALVPSFTVTKLRWLARHEPEAAARTAAICLPHDHLTRLLTGELVTDRGDASGTGYWSPAENAYRPDLLRLALGHEPQVPRVLGPSELAGHTAEGVAVSAGTGDNMAAALGLGLAEGDVVVSLGTSGTVFAVSAAPTADPTGAVAGFADATGRFLPLVCTLNAARILDAAARMLGVDHAELSRLALSAPPGADGLVLVPYLEGERTPNRPDATGALHGLRLSTSTPAHLARAAVEGMLCGLADGLDALIAQGVRAERVLLIGGAARSEAVRRIAPRVLGRPVVVPPTGEYVAEGAAVQAAWALSGAQEPPRWDRPDIIAYEAEPVPAIRERYAEARDHVLTRPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZK2</accession>
    <name>A0A1H6BZK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66092">
        <property type="protein sequence ID" value="SEG66092"/>
        <property type="gene ID" value="SAMN04489712_108163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="17981" checksum="4B317FFDACAC4FD3" modified="2017-01-18" version="1">MSLPGSGAVPPREIDPDTMRKVLGHYPTGVVVVTAVHGGEPVGMAVGSFTSVSLRPALVGFFPDSSSTTWPRIREAGAFCVNVLGEDHQDVCRLFATRGADKFGALSWEPGPTGSPVLRQAISWIDCTLENVQEAGDHFLALGRVVDLSARSGGGPLIFYRGGYGGLRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C026</accession>
    <name>A0A1H6C026_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_108132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GmhB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65756">
        <property type="protein sequence ID" value="SEG65756"/>
        <property type="gene ID" value="SAMN04489712_108132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="6">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG65756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="501" mass="53198" checksum="EECE2491F9EA7525" modified="2017-01-18" version="1">MSGYSVVVPTLGRPCLTDCLEALATSRGPLPERVVLVDDRPLGGAPPQVPDELAKLTEVVVSGGLGPAAARNLGWRCTTTPWVVFLDDDVRVSPGWREALAEDLAGQPPRVAGVQGRIEVPLPEDRDPTDWERGTAGLAHARWITADMAYRRAALVESGGFDERFPRAFREDADLALRLERDGWTLTRGTRRTVHPVRPASWWVSVRRQAGNTDDALMRALHGPGWHERAGETPGRRNRHLAITAAGVAAAALAAAGRRGAAALAAAGALAGVTEFAAARIAPGPRTVGEIATMAATSLVIPPAAVWHWLRGLRAAHGARPWPGPARAVLFDRDGTLVRDVPYNGDPAKVEPMPGAREAVELARRLGLRVGVVSNQSGIARGLLTRQDVDAVNRRVEELLGPFDTWQVCPHGDGDGCRCRKPAPGMVERAAHELWVQPHECVVVGDIGADVGAARAAGARSVLVPTPQTRQEESVGARVAGDLVAAVRFAAGDVPGAPLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7K8</accession>
    <name>A0A1H6C7K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68893">
        <property type="protein sequence ID" value="SEG68893"/>
        <property type="gene ID" value="SAMN04489712_10929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="456" mass="50094" checksum="52E945DBC26A3249" modified="2017-01-18" version="1">MYAKPVAAAGLGEARAVADAILYEGYLLYPYRRSSGKNKVRWQFGVLLPQAWAQAHGLSDAGVAGSAESWWQQTECLLEGPRDALVDVRIRFLQVQRRSPEELLPDGDHRPADTIELGSRLELGFDEAVPQEFQVRATVAEVLGGARRVVLRAPGGEESEPLTDEQGRRAGRVLRRRWPVTAVVTLSATACRTPFPLHRLQVRVENTGEATPPEAARDEALRSSLIASHALVAVHGGSFVSLLDPPQWAQEAAHECANVHTFPVLAGEPGRRDLVLSSPILLYDHPRIAPESPGDLHDATEIDEILSLRTRTLTEEEKREARATDPRAAAILNRVDTMPPEVMARLHGAVRSPDPASEAPWWDPAAHASTSPDTDSVVVDGVALARGSRVRLRPRPYGTDPQDRFLDGRTALVEAVLLDVDGAYHLAVTLEDDPAAELNQWYGRYRYFAPDEVRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAL7</accession>
    <name>A0A1H6CAL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mutator mutT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_109133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70001">
        <property type="protein sequence ID" value="SEG70001"/>
        <property type="gene ID" value="SAMN04489712_109133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG70001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="17129" checksum="D0406185E9C21F5A" modified="2017-01-18" version="1">MSTTDHPPFLVERNPGYFEYQLPVSVKLIIDYGGKVPLLKNEREEWELPGGKLEVGERPDECVAREVEEELGLTVKVEDLVDTWVYEITPLRHVFIVTYGAHYTGFQTPRSSNEHKALGLFSPGEVGGLTMPEQYKTSIKRWYAMTGKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDL9</accession>
    <name>A0A1H6CDL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70933">
        <property type="protein sequence ID" value="SEG70933"/>
        <property type="gene ID" value="SAMN04489712_109222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="23726" checksum="4F63525A66BA67C9" modified="2017-01-18" version="1">MSRWPAADVTVAPQPKVLKATNGRMSRALSTLVFSREALMPPEFSSIEEWLGRGQNTYAYYQVLEEVGGPRWSPQRDTHPWIRFCLRAHHIQAQQARRRIDLLDRAWIALSEAVTGAGLDERTAFALLPAFWGSRVRRTIYQQDAELSVQQSIRDIRELCRLRWLAPQGEARGRYYTAGPAMQPVMDAVKRSTQPFDDPYRDARVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDW3</accession>
    <name>A0A1H6CDW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71023">
        <property type="protein sequence ID" value="SEG71023"/>
        <property type="gene ID" value="SAMN04489712_109232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG71023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="79" mass="7971" checksum="056C85A5FB8A6474" modified="2017-01-18" version="1">MTRYEAEDAEDKAEAAETGPVCGLAAVGLSGPRPGAGRSALGRGGPAVGQAWRRRSFRTLSGRVAGRPSGSVIALSTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CE63</accession>
    <name>A0A1H6CE63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_109253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71244">
        <property type="protein sequence ID" value="SEG71244"/>
        <property type="gene ID" value="SAMN04489712_109253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG71244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="217" mass="22879" checksum="E5FCD3A7C3BBEB74" modified="2017-01-18" version="1">MADRPITVLIADDHPVVRQGLRTFLGVQDDLRVVGEAADGAQAVSLAETLRPDIVLLDLNMPAGGGLAALRELRARGLPTRVLVLTSMTERGHVLPAVRAGAAGYLYKDVDPPALAQAIRAVAGGNVLFAPEAAEAVLDGGSSSGPRPGPDEPRLTDREREVLVQIALGRSNREIARALVVSEKTVKTHVSNLLMKLGVQDRTQAALYAVRHGLADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJA0</accession>
    <name>A0A1H6CJA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73054">
        <property type="protein sequence ID" value="SEG73054"/>
        <property type="gene ID" value="SAMN04489712_11066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023932">
        <property type="entry name" value="Uncharacterised_CE1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04037">
        <property type="entry name" value="LLM_duo_CE1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="2">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="21632" checksum="B27E74AB664BC76B" modified="2017-01-18" version="1">MSTRRIAVVSAGLSVPSATRLLADRLTAATVDALRERDVQGRAEVVELRDHAHDITNNLLTGFPAAALRRVTDAVAGADAVIAVTPIFSASYSGLFKSFFDVLDQDALTGRPVLIAATGGTARHSLALEHALRPLFAHLRAVVVPTAVYAASEDWGTGGDADRGLADRIARAAGELADLLADRTPTVRKDPYEDPTPFKDLLPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM57</accession>
    <name>A0A1H6CM57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_110122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73536">
        <property type="protein sequence ID" value="SEG73536"/>
        <property type="gene ID" value="SAMN04489712_110122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG73536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="504" mass="53254" checksum="80272F804FC114E3" modified="2017-01-18" version="1">MTAVTEVKTFKLPDVGEGLTEAEIVRWHVQPGDQVEVNQIIVEIETAKAIVELPCPYEGEVAGLLVEEGRTVDVGVPIISVRVAGESAESAEEVEPPVVVSTAEQLAAKEDLVPSAAADPGTHVAPDTGPDKPKRQPVLVGYGVKPGATRRRPRKRPAPARSAQPTGEARRALAKPPVRKLARDLGVDLAAVAGTGPHGTITRDDVRLAARERAAGPLAGENGRAPAAAPAPERVTRSAPVPERPVVHEGRGVPASLSLSEGAVPPAGAREERIPVRGVRKSTASAMVRSAFTAPQVTEFLQVDVTEMMETVRRLRELPEFAEVRVTPLLLVAKALLTAVRRHPMVNASWADGGGAGDEIVVRRYVNLGIAAATPRGLLVPNIKDADRMTLPELAAALGRLVETAREGRAQPADLTGGTITITNVGVFGVDAGTPILTPGEAAILAFGQVRDMPWVHEGELAIRRVTTLSLSFDHRIVDGELGSAVLRDVGAMLENPLRMLAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTA0</accession>
    <name>A0A1H6CTA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76251">
        <property type="protein sequence ID" value="SEG76251"/>
        <property type="gene ID" value="SAMN04489712_111141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="1">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="103" mass="11245" checksum="8CC6239169BBF9B3" modified="2017-01-18" version="1">MSSHPRHRLDEVIHSPVRFAIVATLAAADKAEFGFVRDTVEVTDSALSKQVATLEKAGYVKVTKGYVGKRPRTWLSLTPQGRSAFTDHCTALREIADSALHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVF9</accession>
    <name>A0A1H6CVF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enterochelin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76954">
        <property type="protein sequence ID" value="SEG76954"/>
        <property type="gene ID" value="SAMN04489712_111229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG76954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="332" mass="35600" checksum="62DD13F0CB2F30A2" modified="2017-01-18" version="1">MLTDGDRVEPVPARYEAADLDRRLSGGHQVAFADGEILTLACRGTDAVAHVFDLEIPMVPVGAAGLLALSLRVPRLEEAIVSFHCEAEPAPDRPPGYGLWRGPKAPPPVRRAPVTLAQVRTVPLRSAALGGPRTLRVYHPPIPPGAPRRVLFGTDGEAWEQVVEPLIRDGALPAIIAIGVENGGPARLREYVAGIDRVRFAAHRRFFAREVVGWAERELGISPDPAHRAVAGVSNGADFAAAIGVLEPGRFGGVIALSCGRIDPRRVPPGRGGARQWLAAGTLEPGFRKVTGRWADALERAGVEHVHRVRVAAHDPAMWGQEVAAALPWIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVU2</accession>
    <name>A0A1H6CVU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76536">
        <property type="protein sequence ID" value="SEG76536"/>
        <property type="gene ID" value="SAMN04489712_111175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="416" mass="46636" checksum="4992DF2CCEEE8C6E" modified="2017-01-18" version="1">MPPFVPGPRCGSPADAALADAAPADEAPAAQAEPDEQRIRRRLERLIGIAATEGNTLLPLRNGDEIFPAMLESIRSAERTIDMMTYVYWRGDIARRFAAALCERAKAGVRVRLLLDGIGCHPIEHDLLDDMSESGVTVAWFRKPLLLSPFKQNHRCHRKVLVVDETVAYTGGVGIAEEWCGDARNEHEWRDTHVQVRGPAVDGIAAAFAQGWAECHDELFDDRDRFTPHESAGDAVVQVVRGSASIGWQDMQTLMRVVLESAQHRVRLATAYFAPDDYFTELLGSTARRGVEVDILLPGPHADKRVSLLAGRQHYDRLLADGVRVWEYQPTMMHAKILTMDGIVSLVGSTNFNRRSMDHDEEIMLAVIDRELTATLDGHFEKDFAVSERIAPGRWRRRSHLHRAKELSVTPIRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVU3</accession>
    <name>A0A1H6CVU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76968">
        <property type="protein sequence ID" value="SEG76968"/>
        <property type="gene ID" value="SAMN04489712_111231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG76968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="12214" checksum="FB5E7DB3F09E12EA" modified="2017-01-18" version="1">MSTVLTKNPLWTSRSMLPSEPLKLEESVLNPTTPEESRPLAYLYCDWDPGISGDSSPEVEFGHYDPVTQTWDDTNSPIKAGVITQTRRWTEYAPGTGWWDYVSDDACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVV8</accession>
    <name>A0A1H6CVV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77161">
        <property type="protein sequence ID" value="SEG77161"/>
        <property type="gene ID" value="SAMN04489712_111257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="146" mass="15159" checksum="8039062E04B74B27" modified="2017-01-18" version="1">MRFLARTHQLPARMAAGALILHSGLSKKDADEQKAAGLHGMAAGAYPFLKEMDPAAFTRLLSCSEIALGAALLLPVVPSVVAGAALTAFSAGLLGFYLRTPGMRREGSVLPTEQGLSVAKDVWLLGIGASLLTEELTCGDGHRMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CW78</accession>
    <name>A0A1H6CW78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76963">
        <property type="protein sequence ID" value="SEG76963"/>
        <property type="gene ID" value="SAMN04489712_111230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="10654" checksum="479C8F69B47B8ECC" modified="2017-01-18" version="1">MTFLRLDPPELTGTNMVVRAVPADARALRRSDPHAPFAYLYEQPPPFSPEEDIVLAAGHYDEVNLVWSFSGEIHGITGITEPRPSPESLEGGAPCPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYC8</accession>
    <name>A0A1H6CYC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78042">
        <property type="protein sequence ID" value="SEG78042"/>
        <property type="gene ID" value="SAMN04489712_11218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="93" mass="10343" checksum="A5AFEEE2A3F23CA4" modified="2017-01-18" version="1">MVATLDQGSLRFTDLHRQIPGISQRMLTLTLRNLERDGLVSRTVYAEVPPRVEYALTPTGKSLIPPALALAGWAIEHVPHIEASRQAYQARNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0G1</accession>
    <name>A0A1H6D0G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78076">
        <property type="protein sequence ID" value="SEG78076"/>
        <property type="gene ID" value="SAMN04489712_11224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG78076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="45438" checksum="1291BC2D57D3343A" modified="2017-01-18" version="1">MTAETLLERITDYANRPDPYPLYAELREAGPVVGQADGSYLVGAYHEITALLHDPRISADPRSRRAPAPGPFEEEAPQPPFLRLDDPEHHRLRTLAMRPFGPPHSPGRIDAMRGQITELTDELIEGLRDRPRIDIVDDFAYPLPVTVICRLLGVPRTDEPLFRQWSDAIIAAADVRPEQDTTERDRPGDQARTEMGRYLVDLAEQRRGHPSDDMLSAFVNEPDPAMRLTREELAETAVLLLIAGHETTVNLITNGVLTLLRHPDQLDRLCRDPGLLPGAVEELLRYEPPVHMRERIPLADIDVADTTIPQGTSVVLVLASGNRDSERFHEPDRFDPTRPDNRHLGFGDGIHLCYGAPLARIEAHIALGALIPHLGTVTLVQDPPPYRHNAMLRGPRHLLIQRQQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0Y7</accession>
    <name>A0A1H6D0Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv3520c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78698">
        <property type="protein sequence ID" value="SEG78698"/>
        <property type="gene ID" value="SAMN04489712_112113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="37831" checksum="FAE93192D1DD8574" modified="2017-01-18" version="1">MRIGMSLSYAGGFKETVQELADYERAGLDIVFVPEAYSFDAVSQMGYIAARTERLQIASAILPLYSRTPTLTAMTAAGLDHVSDGRFVLGIGASGPQVIEGWHGVPYSAPLDRTRETIEICRAVWRRERLEHHGTHYRIPLPPGEGTGLGKPLKLINRPERDRIPILIAALGPKNVALTAELAEGWKPILYLPERAGQVWGAALAEGRAKRDPALGELDIVATAFLAIGADVEGVLDLARPGVALYVGGMGAKGRNFYNDLVRRYGYEREAEQIQDLYLAGRKDEAAAKVPYQLLKDTSLIGTESYVRERLAALAESGVTTLSVTPVAGTHADRVRLIERICDLAADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1Q2</accession>
    <name>A0A1H6D1Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative zinc-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_112192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79271">
        <property type="protein sequence ID" value="SEG79271"/>
        <property type="gene ID" value="SAMN04489712_112192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG79271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="26856" checksum="7D0CCFE8109382A8" modified="2017-01-18" version="1">MSMACEDVRVSLGVYVLGAIDPAERSMVDAHLTACPACRDELAGLAGLPALLGRVSESQLTALAEPPGELLEPLLARAAAERRGRLPRLGRRDGQGRGHWSGRWTPLIAAAAVALVVVALFGGFLSGRFDGSPPPVAQPPSPSQTRPQPSPSHEVEELYASDARTGASARLVVTTKRSGTQAELHLKGVPLGSHCRLEAVDRYGRRDSMGSWEVAYRSYSTFTGSTMFQRDRVTSFQVVTDDGRKLLVIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3Q4</accession>
    <name>A0A1H6D3Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteins of 100 residues with WXG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79413">
        <property type="protein sequence ID" value="SEG79413"/>
        <property type="gene ID" value="SAMN04489712_112212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="23302" checksum="9C5DCEDB64FB4F2F" modified="2017-01-18" version="1">MSFVESGKWLCMMAIAEATAASFVIPAAIPMTVMIGLSYSDPGAMETAGAEWKQTAKELENMKDELKQMAAGVPEEKWSAKDREAFNKALEQYSQELDKVHGFTGDVGDMLDMASKIFFAFAVLAFALAQILAIQALAIIAASWTVVGAAALMAAANATAGVFDGIIAASSISLKTAVLLIGGIIGAGMIVYSQTAGKGANPDGSGPVMFKKAQIAPGGMPNLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4D1</accession>
    <name>A0A1H6D4D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trehalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80192">
        <property type="protein sequence ID" value="SEG80192"/>
        <property type="gene ID" value="SAMN04489712_11336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="459" mass="50048" checksum="A90E53931219E10A" modified="2017-01-18" version="1">MTTVSAMHPSPAPAARLTRNQTAARAAYVLAGNDRGRLTVAAPQLYPHMWSWDAAFIAIGLARVSTGRALTELETLLAAQWRTGMVPHIVFTEGDATYEPGPQRWACRETCPDAPDGPATSGLIQPPVHGVAVRRILDAARTASTAERREAVQRIRALWPALLAWHRYLATRRDPDGRGILTIYHGWESGLDNSPRWDAPYAAVVPAPEFVPFRRADLHALGALGGAAAQRPSDADYAKYQWLVEELRRAGYDDERARRTLSFRMGDVLTSALFVAANEELATVADELDLPGVDELIGYADRFRRGVLQTADERGFAADIDLRTGAVVRTETVAGFAPLLSGGLDPARRRALVATLTSADWCGHPGFAHALPPSTSPNSAAFDPVRYWRGPQWPPVTWLMVWGLERSGEQETAHALREAALDQLADGLFAEYYHPFTGEPLGARPQSWTAAVALDLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D546</accession>
    <name>A0A1H6D546_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein N-acetyltransferase, RimJ/RimL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80098">
        <property type="protein sequence ID" value="SEG80098"/>
        <property type="gene ID" value="SAMN04489712_11312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="20940" checksum="A643E0CBD67BED90" modified="2017-01-18" version="1">MRDLTTVRLILEPWRERHGSELVRLSADERVMRHIGTGVWTRGYATRRHVRALRHWAEHGFGWRAVHARADRSFLGLVSLIRLDAPIEGIAEPALEIGWWVDPRAWGQGIATEAAAAMLDEAFGRIGAETVVARLQAANLGSARVTAKLGLRPFAETTDPDGRLMLMCAITRDEYRRAGGAPPAPPAPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D549</accession>
    <name>A0A1H6D549_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80432">
        <property type="protein sequence ID" value="SEG80432"/>
        <property type="gene ID" value="SAMN04489712_11379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG80432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="22446" checksum="068EC0653EDD4590" modified="2017-01-18" version="1">MPRRRSLTHVQIAEAALAVIDRAGLDGLSMRVVARELGVSTMALYRYVEDREHLEGLVVDHMLASVDVSLPADLPWQERVAVLLERMREAVGAHPAAVPLTVVHRHAAPNLLRCAEALLGVLTEAGFTGRGRAVALRALLAHVIGALALMHLGPLAGQGTAAMGDLPVERYPHLADTARRARQIPPDEEFRRGLDIVLCGLAVDGGAVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D959</accession>
    <name>A0A1H6D959_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_114136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81759">
        <property type="protein sequence ID" value="SEG81759"/>
        <property type="gene ID" value="SAMN04489712_114136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="139"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG81759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="37941" checksum="73AA3CEE165CACB5" modified="2017-01-18" version="1">MTDARLLGDDEAAFIAAARSNDAAQFALITERYRRELQVHCYRMLANYEDAQDMTQETFLRAWNKRESFKGHAALRTWLYRIATNACLDFLEKRNDRIPVPAGLPGAGSEVRYLQPYPDRMLPEDPQESVVARETIELAFIVAVQHLPPRQRAVFILRDVLGWPASKAANALELTVASVTSALQRARVTMREQLPDRRLDWRSPATHELSDDERGVVKSYMDAHERNDLNGLMALLRDDLRFAMLPEPGTLIVTAKDAVDGWVSSGLFQRGYDDWRCIATTVNRMPAAVLYLRTPDDPEYRLFNIAVLHIVDGKVAELTGFDATDKPWLSLPATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBR3</accession>
    <name>A0A1H6DBR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_115104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82897">
        <property type="protein sequence ID" value="SEG82897"/>
        <property type="gene ID" value="SAMN04489712_115104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTRA" evidence="2">
        <location>
            <begin position="27"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="19032" checksum="50A681BCB9921181" modified="2017-01-18" version="1">MWITSSLPYLSPRGEGEADPWSQEAARAGQAGTQKLREVVSETPPVEVAAMLELPEGASAVVRRRTMLMDGRPVELTDSWYPADIASGTALAEPGKIRGGAVTLLARLGYVVHEAREEVEVRNATPQEAAELAIPGDAPVIVLRRTCLTAQEVPFEASVMVMVPEGRRLRYRLIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCB5</accession>
    <name>A0A1H6DCB5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_115150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83117">
        <property type="protein sequence ID" value="SEG83117"/>
        <property type="gene ID" value="SAMN04489712_115150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12455" checksum="52974BDED89F36A2" modified="2017-01-18" version="1">MTANAGATAPGGTARSTPAARVLMLLVRGYRRFLSPLLGQQCRFHPTCSAYSLEALQIHGALRGTWLTARRIGRCHPFHRGGYDPVPPPKGDLTRSETAGRTPSGPPIGEPKELPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDU0</accession>
    <name>A0A1H6DDU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-erythro-3,5-diaminohexanoate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83528">
        <property type="protein sequence ID" value="SEG83528"/>
        <property type="gene ID" value="SAMN04489712_11613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="380" mass="39185" checksum="21AC302DE6C92CE9" modified="2017-01-18" version="1">MSEADQVRTDRARAGGSAIGLHRVLDPPGVLPQAARRLDPDPAIGPDEVRVRVERLNLDAASYRQLHEAHGGDPDAIRARVLQIVRERGKMHNPVTGSGGMLVGVVEEAGPGSPLGLAPGDRIATLVSLTLTPLAITDGLARWDGRGEQVPADGHAILFARSIAAVLPEDLPVPLSLAVLDVCGAPALTERVVGRHAAETAARADSRADWRADSRTEAGPVVAVLGGAGKSGSLSLAAARRAGARHLIGVVPDRAEETRLARSGLADRVVVADARDPVAVEAAVRAAGGPADVTVVCVDVPGCEHGAILATAPGGTVVFFSMATSFPAAALGAEGLAADVTMLIGNGYVPGHARTALDLVRGSPALRELFTARLRHLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDW6</accession>
    <name>A0A1H6DDW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_115109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82933">
        <property type="protein sequence ID" value="SEG82933"/>
        <property type="gene ID" value="SAMN04489712_115109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PTHR42893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG82933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="466" mass="48463" checksum="549CD325330A2E1A" modified="2017-01-18" version="1">MTIITSLVVSIFVMPGPPSRRTRFPLRRPRLRHPHDREILRLAVPAFGALVAEPLFLLADSAVVGRLGTAQLGGLGVAGQALATLVYVFVFLAYGTTAAVARQIGAGDPRAAIRQGIDGMWLALVLGVAVIALGWPLVPWIVEAFGANPAVAPYAETYLRISLFGIPGMLVILAGTGVLRGLQDARTPLWVSVGSFGLNLVLNVLFVLVLEWGIAGSAWGTVIAQTGGAAVYVAAVLRGARRHGAAVRPSGAGLRASVRSGAHLLVRTLALRLVLIVGTAVAARMGTDETAAYPVSFQVWTLLAFAHDAIAIAGQSITGRYLGAGDVPGARAATRRMVEWGVVGGVVFAVAVLAVRPWLPALFTSDQGVRALLLTALVFVAALQPVAGVVFVLDGVLIGAGDMRYLAVATAIATAVFLPAALLVYWLGAGLAGLWAAIGLWMATRLVTLGLRARGDAWLVTGAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE78</accession>
    <name>A0A1H6DE78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83534">
        <property type="protein sequence ID" value="SEG83534"/>
        <property type="gene ID" value="SAMN04489712_11615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="42142" checksum="EAE1C3851A5D1592" modified="2017-01-18" version="1">MQHGHTPGFPLGATVTIEELQDDPHPALARLRAAEPVSWLPALGGWLVTRRDLALRVMRDAVTFTVDDPRFSTAQVIGPSMLSLDGPAHHRHRDPFSRPFRPARTRERFTAFVQDEVDRLVTALLPAGRAELRGEFAGPLAVAVVAEVLGLPDADPAVVRAWYETFVTAVSDITAGRPGEAAAAREQLRAAVRAAIAAPDGSLLAEIAAGPWEPTTEEVVANAAVLMFGGIDTTEGMIVNAVQQLLAHPAQLALVRADPGLLDGAVEESLRLEPAAAVVDRYATADVELAGAPIRAGDLVRVSLTGANRDPAVFPEPDRYDVRRANAADHLAFAHGPHFCFGAPLARLEARTALRALLDRLPGLRLDPARSSAPRGLVFRKPQALYVEWDASGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE98</accession>
    <name>A0A1H6DE98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83757">
        <property type="protein sequence ID" value="SEG83757"/>
        <property type="gene ID" value="SAMN04489712_11662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="223"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG83757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="377" mass="39436" checksum="27863D0CBCBEE356" modified="2017-01-18" version="1">MPAESPGLSELHDELRAVARDLLGKADAEAAADWRSIAGAGWPGLEVPGAFDGADATFAEVAVILQEMGRAAARGPYAAVAVLGVGVLNLLESGPDRDRLLRDTAAGDAVPVAVLEGEAMGETSFRIARTARGPLLHGTADFVLDAPAADRLLVPALDPDGTPVIVGVDPRAAGLSVERRPVLDATRGFGRVAVTDVSVPPESVWRFRGDPQEAVRRLRDRAAVAMACDSLGLSKAMLEATVAYAGVREQFGRKIGSFQAVKHACADMLVQVSVARELVAAAVRGQAGDEPGAAVAASMAKSYACAAAVEVAGKAMQLHGGMGYTWESGVHVYLKRAALNRSLFGSPALHRRRLAERYSPLARERLDAYGGSERSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DES6</accession>
    <name>A0A1H6DES6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv2161c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83552">
        <property type="protein sequence ID" value="SEG83552"/>
        <property type="gene ID" value="SAMN04489712_11620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="32691" checksum="6045491EE90E8C22" modified="2017-01-18" version="1">MLIGCAVPVSGPWATPAGQLRIARRAEELGYHSLWTLQRLLNPAGEVEDARSRRYHKVGDPLVTLAYLAGLTSRIRLGVAVVNMPFFSPPLLAKQAATLDQVSGGRLDLGLGLGWMPVEFAASGVPMERRGARAEEFLAALRALWAQEVASYDGEFYRIPPVRMEPKPMQRPGPPILLGGGAPPALRRAGRLADGWVSSSTADLSTIGAQIGIVRDAAAQAGRDPDALRFVCRGAVRVRPAGRPDRAPLTGSYEEIGEDFARLAAEGVTEVFVDLNFDPELTGPDTDPAASLDRAEEALEALRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFL4</accession>
    <name>A0A1H6DFL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_116127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84020">
        <property type="protein sequence ID" value="SEG84020"/>
        <property type="gene ID" value="SAMN04489712_116127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="4">
        <location>
            <begin position="15"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG84020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="313" mass="35194" checksum="3D6CC63E4A2FE19B" modified="2017-01-18" version="1">MVRGQANPHVSRLRKHVGDVQITTGDLLDQGSLISAVERVQPDEVYNLGAISYVPMSWQQAELTAEVTGMGVLRMLEAIRVVSGVGQSRTPGAGQIRFYQASSSEMFGMVRETPQNEKTPFHPRSPYGVAKTYGHYITQNYRESYGMFAVSGILFNHESPRRGAEFVTRKVSLGVARIKLGLATELRMGNLEARRDWGYAGDYARAMRLMVNQERPEDYVIGTGRTQSVRELVELAFGSVGLNWQDHVVLDSRYTRPAEVDLLCADPKKAREQLGWEPEVGFEELVAMMVESDLRLLSRSNRPEDEPFSPDHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGV4</accession>
    <name>A0A1H6DGV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetolactate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83836">
        <property type="protein sequence ID" value="SEG83836"/>
        <property type="gene ID" value="SAMN04489712_11678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="194"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="393"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG83836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="568" mass="61834" checksum="A4184E69C337AA7C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHH4</accession>
    <name>A0A1H6DHH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84661">
        <property type="protein sequence ID" value="SEG84661"/>
        <property type="gene ID" value="SAMN04489712_11744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="26"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="22402" checksum="272F3E0F9D666626" modified="2017-01-18" version="1">MIGEMGAMARAVRRDTVLHSFERVQGEVEARLAAVPPPMMGRPTHLPGWDVRRLAAHLVWVDLRYAAMADHRDPPPRETESAGDGIGGDAAALRRAGERARLAFARPGMLEEWFAAPWCGEQGGCEPGYVLVQHVVIELLTHGWDLARATGQPTDLAPEQARQALEVVHAWYGDPVARGGAGFAPPRPVPEGAGQADRLAAYLGRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHR4</accession>
    <name>A0A1H6DHR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84868">
        <property type="protein sequence ID" value="SEG84868"/>
        <property type="gene ID" value="SAMN04489712_11782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="344" mass="37169" checksum="DE7B5814F4A03FB4" modified="2017-01-18" version="1">MAEDFTGQVVVVTGASAGIGRATALRFAERGAKVALLARGRKGLQAAAREAEKACGPGNALPISCDMADYAQVERAADRVEHELGPIDVWVNAAFSSVFAEFLDIVPDEFRRTTEVTYLGFVHGTRAALERMMPRDRGVIVQTGSALAKRGIPLQSAYCGAKHAIQGFYESLRCEMLHQGTGVRMTMVHMPAVNTPQFDWVLSRLPRHPQPVPPIYQPEVAARALTYAAAHPRRREYWVGASTVGTLLANRVVPGLLDRYLALTGYASQQTDRPRDPHAPANLWEAADDDDGRDFGVHGSFDERAHGRSPQQWLSRHRRALGLAGLAGGAAAGAAAGLLHAGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJR4</accession>
    <name>A0A1H6DJR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_117131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85073">
        <property type="protein sequence ID" value="SEG85073"/>
        <property type="gene ID" value="SAMN04489712_117131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="329" mass="35031" checksum="F385114EF3FF8ACD" modified="2017-01-18" version="1">MRRRLLGRSGMRVSELCLGTMTFGTGGRGGGADETACREIYAAYREAGGNFVDTADIYTAGQSESIVGRLVAGERDSIVLATKFTLPTDAGDANSGGGHRKSLRRSVETSLRRLGTDYVDLLWVHAWDQCTPGEETLRALDDLVRSGKVLAIGVSNTPAWVVARSQAIAELRGWSAFCALQIEYSLVSRSVEREFLPMAQALGLTVTAWSPLARGLLAGKTPPARDTPLAPSRERVANAVAETAKVAAELGTTSPSVALAWLLGRGVIPVLGASRQAQIRDNLGAAGLRLDDAQTERLDAATRIGLGYPYTLLNERFPMLSAAAYAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKK1</accession>
    <name>A0A1H6DKK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homogentisate 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85734">
        <property type="protein sequence ID" value="SEG85734"/>
        <property type="gene ID" value="SAMN04489712_11869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="33" mass="3722" checksum="24E2BF36297EFD91" modified="2017-01-18" version="1">MIDAFRLLPSGPAAARCEDPEDPEYAWSWARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMM7</accession>
    <name>A0A1H6DMM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86560">
        <property type="protein sequence ID" value="SEG86560"/>
        <property type="gene ID" value="SAMN04489712_119111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="15334" checksum="27AD2A80471A18F3" modified="2017-01-18" version="1">MLRGLTTVSFYAHDVVAARDWYAEFLGVRAYFQRPEQGDPAYVEFRVGDYQHELGIIDTRFAPDGWSTEDGGAIVYWAVDDLEAAWERLLEMGAAPLEKPTEHGPGFVTASVRDPFGNILGVMINHHYMDVLAGRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPI4</accession>
    <name>A0A1H6DPI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_119110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86556">
        <property type="protein sequence ID" value="SEG86556"/>
        <property type="gene ID" value="SAMN04489712_119110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG86556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="34772" checksum="BA5C31380CFD4286" modified="2017-01-18" version="1">MAVLLLMQSRGRVTAAEIAAEMEVSVATARRDLEALSAAGVPVYPQAGRGGGWALLGGARTDLSGLKASEARALFLLLGPAAAIAPEAKAALRKLVRALPSTFRQEAEAAADAVVVDPARWGEHRRTRPVLVDLLEDAVVRRRKARLTYSGRERVVAPFGLVDKDDTWYLIAGTPDGQRTFRVDRVTDAEVTEEPAERPTHFDLAAAWDEVVTAMEARRATTTATATVDARHLPVLRDYFGRHCEVISQGERVRVTLTAPTALDIARQLAGWGDLVIVEGPQTVRDELAKLAAQLTTLYGRQDQGQWPSPPTPPARRSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPI5</accession>
    <name>A0A1H6DPI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87178">
        <property type="protein sequence ID" value="SEG87178"/>
        <property type="gene ID" value="SAMN04489712_12083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13751" checksum="D02CCF823BA1868D" modified="2017-01-18" version="1">MKVPPPSPDAVTARLCAGLRLPERVHGQERRETSPESPLTAAWGSPAIALRCGVPRPAAMRPDAALVTINGINWFPYPADRPVTYTAVGRQAYVEVTVPAKYEPAGDVLIELGDSIKATIPEKPEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRP3</accession>
    <name>A0A1H6DRP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87890">
        <property type="protein sequence ID" value="SEG87890"/>
        <property type="gene ID" value="SAMN04489712_12127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="75" mass="8066" checksum="022987BB9387DB8E" modified="2017-01-18" version="1">MDRLEASARTLSRGAFRVFVVAVVLKQAPWRVAFIVLVNAVAAWAFRAPAVVGASLGACPGKGSRDVRSRNRKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRP4</accession>
    <name>A0A1H6DRP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_120122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87383">
        <property type="protein sequence ID" value="SEG87383"/>
        <property type="gene ID" value="SAMN04489712_120122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG87383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="15267" checksum="5AEAA42FD272C26B" modified="2017-01-18" version="1">MILTGRDYADVAVGEELPELSIPLTRTMIVATAIASRDYQDVHHDPGLAVERGSRDVFMNILTTNGLVDRYATSWAGPAARVRAIRIRLGAPNYPGDTMTLTGTVSAKDDAARRVEIAVRGTNSLGAHVTGTVVIELPEGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DW76</accession>
    <name>A0A1H6DW76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombination protein MgsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89334">
        <property type="protein sequence ID" value="SEG89334"/>
        <property type="gene ID" value="SAMN04489712_12370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="111"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG89334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="504" mass="54268" checksum="2C4A705682A48129" modified="2017-01-18" version="1">MAGPSPHHEVPGFAGRAAARPRADSLEHMSRVDPAQADGLFDEPGREPAQPPAAASSSASTSSAGPAAGGVPAAQQPLAVRMRPHGLDEVVGQEHLLGPGTPIRQLVDRDVPMSLVLWGPPGTGKTTLAYVVAGVTRRRFVEISAVSDGVKRVRAEIDLARRELGMTGRQTVLFVDEVHRFNKAQQDALLPAVENRWVSFIGATTENPFFSVISPLLSRSLLLTLEPLGEDHLREVIARALADERGLGGRVELTPEATDHLIRLAGGDARRTLTYLEAAALVVPDGRAIDVEVLEKAVDRAAVRYDREGDQHYDVVSAFIKSIRGSDVDAALHYLARMLEAGEDPRFIARRLIVHASEDIGMADPTALQTATAAAHAVEFVGLPEARINLAQAVIHLSLAPKSNAVITAIDQAIGDVRKGLVGQVPPHLRDAHYKGAAKIGHGEGYRYAHDFPGGVVRQQYAPDAVADRRYYRPTRHGAEARFSEVLDRIRAVLRGHRDGGRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWX1</accession>
    <name>A0A1H6DWX1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_12459</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89771">
        <property type="protein sequence ID" value="SEG89771"/>
        <property type="gene ID" value="SAMN04489712_12459"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="351"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG89771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="436" mass="48130" checksum="F7423706BDDCCC0A" modified="2017-01-18" version="1">MIERYTLPEMGRVWSDAHKYELWCRVETLVVEAHAEAGTIPAEVAEPVRKAPPPTPERVHEIEAVTQHDVIAFLSAWADNTEPREAAAYVHFGMTSSDLLDTALAVQLVEATDILLEKADRLVAVLRDHALEHRGTLRVGRTHGIHGEPDVWGHRVADFAFAMARSRDRLRAARAAVGVMAISGAVGTYSNIDPAVERYVADRLGLKPADVSTQVVIRDGVSEWVSALAIMATVCEAIALEVRHGQRTEVRELWEPFGKGQKGSSAMPHKKNPIMSERLAGMARIVRAQVVPVLEGIPLWHERDISHSSTERIALPDASIALDYMLNLTIRLMSGLVVDADRMRANLESTGGLIYTSTVLLELVEAGMSRDDEAYPLVQKAAMETWESGVPFRETLRKHAAEAGLTLDEARLDEVCRPERFVARLGPVFERLTALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZQ8</accession>
    <name>A0A1H6DZQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90820">
        <property type="protein sequence ID" value="SEG90820"/>
        <property type="gene ID" value="SAMN04489712_12748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040868">
        <property type="entry name" value="DraK_HK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18092">
        <property type="entry name" value="DraK_HK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="209"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG90820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="425" mass="45479" checksum="9B7F19BF9373F249" modified="2017-01-18" version="1">MRRRLLLSTLAVALVAILLLGIPLAYATHRLIYEEAHQSLERETSTILGGVQLSLSTGRMVTADRVAQGYPGRYIVITLPDDTVLTAGNRPAKGAELLTHSRAAGGIRVQVSQPAAEVREEALRQLLLIGSLALLGLAVTVGLAMFQARKFTLPLSDLAETADRLGTGNARPRRRRYGIPEVDRVAEVLDRSAVRIADLLAASREFASDASHQLRTPLTALSMRLEEMVEAADYPDIVREEGAAALAQTERLVAVVEQLLARARHDRTGAAEPVGLDDVVAQQVEEWRPIFRRAGRDIRLTGERGLVGLVSPAGLSQILATLLDNSLVHGAGTVTLTTKNSAGSVVVEIGDEGSGVPAELERRIFERSVTGGDGTGLGLYLARSLAVVDGGRLELLQARPAVFAVFLRQAAERHLAEEPVVVGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0B5</accession>
    <name>A0A1H6E0B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, luciferase family (Includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90365">
        <property type="protein sequence ID" value="SEG90365"/>
        <property type="gene ID" value="SAMN04489712_12615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="36167" checksum="6277AE4518D32CF1" modified="2017-01-18" version="1">MQVGLLFDLRNPEPWQRPWTDHYARSLELCEEADRRGVGGLWFTEHHLFEDGYLPQPLTMAAAAAARTRNARIGTAVMLPNLRHPAHIAEEAAVVDLISGGRLELGFGAGYGVLEYALFGADHGRRFRNVERNIGEVLRLWREADVTPLPVQDPVPVWGGFYGPRGAGIAGRLGLGLLHISPEMFEHYRAGLVEGGHDPASARVSDLLPVILADDPEAAWPRVAPHLAHQKNTYRATWAAGTDLPTPPLLHPEDFPEERPADGSWTMLEILTPEDAAVRIHEKIRGLPVQHLIFWASVAGMPDDLVVRNIELITDRLPELLEKASAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0F7</accession>
    <name>A0A1H6E0F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90694">
        <property type="protein sequence ID" value="SEG90694"/>
        <property type="gene ID" value="SAMN04489712_12711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="654"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="1019"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="904"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="672"/>
            <end position="679"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1043"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG90694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1514" mass="160826" checksum="D0CABFAB540D39F9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1D0</accession>
    <name>A0A1H6E1D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Castor and Pollux, part of voltage-gated ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91211">
        <property type="protein sequence ID" value="SEG91211"/>
        <property type="gene ID" value="SAMN04489712_12863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044849">
        <property type="entry name" value="CASTOR/POLLUX/SYM8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010420">
        <property type="entry name" value="CASTOR/POLLUX/SYM8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31563">
        <property type="entry name" value="PTHR31563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06241">
        <property type="entry name" value="Castor_Poll_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Castor_Poll_mid" evidence="5">
        <location>
            <begin position="270"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG91211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="623" mass="67865" checksum="58C532FEF29B1871" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1Y1</accession>
    <name>A0A1H6E1Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91620">
        <property type="protein sequence ID" value="SEG91620"/>
        <property type="gene ID" value="SAMN04489712_1302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="404" mass="44581" checksum="78744696B8F48B4C" modified="2017-01-18" version="1">MTLWRPPQRTPQAEAIYAAAEADRATRPHAYALDPGPIIARALRDTDPAELGDPVHWREGLERYLASAHDDGRLNAVGTRMVRDSAVAALRARLAMNRLAHTNRPLGQPPIIITGGWRTGTTFLYRLLATDPRLRAPLPAELAVPWKFAGASPQRREELIRVGSAANDLLNLLNPALATVHDHSPRLPEECVVAMNSGFRNWGFSATVRLDCYSHWLADQDLTGTYLSYRHVLATLAADSRRWLLKAPAHTAEPPSLAAAFPGACVIFLHRDIVQTIASGASLFCVFRSTYSDHVDPADVGRFQTDQTELWLRRAHAFRRTPQAGAITILDIAYDDLVHDTPAVLHRIYTAAGLTPGDSTSMIDRYHAAHPRNAQGTHHYAAADFALDEADLRTRLAPWTRPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3F4</accession>
    <name>A0A1H6E3F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91415">
        <property type="protein sequence ID" value="SEG91415"/>
        <property type="gene ID" value="SAMN04489712_12910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="107" mass="12111" checksum="6CDDF667E0D7D3E3" modified="2017-01-18" version="1">MSAQPTDLSWALERALCRVLGGYRFEGALNDFVSSLEQLKGSSYDSLSEWLGYGPGLEIELRDEYSGRTETFRMKIERQPVTDICSASPPRRSRIHMGGARRRGRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5D2</accession>
    <name>A0A1H6E5D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92968">
        <property type="protein sequence ID" value="SEG92968"/>
        <property type="gene ID" value="SAMN04489712_13631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="24166" checksum="F1D90105BFE196D6" modified="2017-01-18" version="1">MRSVLLTVEGMSAGYSGVDVVRELDLTIDKGEVVALLGPNGAGKTTTLLALAGVLTPTSGKVRYRDAPLRGALHRRARRGISYISEQGSVFSRLTTLANLRLGPGPVEDALALFPELEPLLGRRGGLLSGGEQRMLALARSLAGKPDLLLVDELSLGLAPLIVTRLLERLRAAADAGTAVLIVEQHASQVLAVSDRGYVLRRGRLSTSGTGAELLASPDVLRSAYLGTGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E680</accession>
    <name>A0A1H6E680_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93298">
        <property type="protein sequence ID" value="SEG93298"/>
        <property type="gene ID" value="SAMN04489712_13812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025234">
        <property type="entry name" value="DUF4177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13783">
        <property type="entry name" value="DUF4177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="51" mass="5938" checksum="9FE372048DD3F6F7" modified="2017-01-18" version="1">MKKWEYATVPLLVHATKQILDNWGQDGWELVTVIPGPNPENLVAYFKRELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7M0</accession>
    <name>A0A1H6E7M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_14013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93687">
        <property type="protein sequence ID" value="SEG93687"/>
        <property type="gene ID" value="SAMN04489712_14013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG93687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="29620" checksum="21352F69E92A70D3" modified="2017-01-18" version="1">MTIIWGGLALGAVYALVAVGYNIVFISSKTFNFAQAQLMMVGTFVAHTGLVTLRLPVALVVLMATAAVMAVAAVEERLAIRPVGDPEAVLVTTLGAAVLLNGLTQLVWGGQPLTVPFFGGDQVLELLGGRVYPVEIALVVVAVALVVLFTWFSRRFVTGLALLAMAEDREAAMLRGIDVRRLAFWTFAASGALAGLLGVFVGPKTFAVATLGASLALKGFVVVAIGGFGSMPGTLVGGLVVGLVEALAARHLGSEYASISVFAVLIAILLVRPSGLFVRTRERAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8R8</accession>
    <name>A0A1H6E8R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93519">
        <property type="protein sequence ID" value="SEG93519"/>
        <property type="gene ID" value="SAMN04489712_13921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG93519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="236" mass="24547" checksum="CBC4585898E00980" modified="2017-01-18" version="1">MSPVLEVRGLTAGYGSLTVLRDVGLTVGEGEIVVVLGANGAGKTTTLRALSGLIPAQGSVVLSGTELLGRKADARARLGLGHAPEGRGTFTDLTVDENLRMGGLRLPRNELPAALDQAYGLFPQLTPLRDRAAGRLSGGEQQMLTVARALMARPRLLLLDEPSMGLAPQITANLFAELRRVNAESGTAMLLVEQNAAAALTIAHHGHVLESGHIVLSGTGSQLAGNPSVRRAYLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9C5</accession>
    <name>A0A1H6E9C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94292">
        <property type="protein sequence ID" value="SEG94292"/>
        <property type="gene ID" value="SAMN04489712_14517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="749" mass="78937" checksum="D832D5E256DF71BC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAW4</accession>
    <name>A0A1H6EAW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000047">
        <property type="protein sequence ID" value="SEG94381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94381">
        <property type="protein sequence ID" value="SEG94381"/>
        <property type="gene ID" value="SAMN04489712_1474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="55" mass="5881" checksum="0CD5B48B93E3E353" modified="2017-01-18" version="1">MDVRDPALRAELERRLDILEREEAGDAAHAALGAGDLWALALLVAVLVAVGWVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECF0</accession>
    <name>A0A1H6ECF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_15011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94699">
        <property type="protein sequence ID" value="SEG94699"/>
        <property type="gene ID" value="SAMN04489712_15011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="57" mass="5806" checksum="45D5F46051E8897D" modified="2017-01-18" version="1">MPTPNPAEPPAASAPSADRPPVSPVPVVRRWVCCHCGGTGLTGDGDTCPHCHGHGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SFQ3</accession>
    <name>A0A1H5SFQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="ORF">SAMN04489712_101186</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49254">
        <property type="protein sequence ID" value="SEF49254"/>
        <property type="gene ID" value="SAMN04489712_101186"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="50"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="216"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEF49254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="31604" checksum="CAC28DB6BA75F1CE" modified="2017-01-18" version="1">MLSLVLPKGSLEKATMELFDAADLTVRRASDRDYRASIDDPRIDRVRVLRPQEIPTYLEQGLFDLGITGRDWITETDSDVVSLGELKYSKATSNPVRVIMAVPNDAPWQSVSDLPEGVRISTEFPAMTQRFLERHGVKAKVVPSYGATEAKVPDIVDAIVDLTETGSSLRKNGLRILDTLLTSYTELVANRQSYEDEAKRAAMEDIALLLQGAIRARGNVLLKLNVSAAQLQAVLDIMPAMSSPTVTSLAGGEAHAVESVVAKRGVNTLIPALKAAGARDILEIPISKIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SH63</accession>
    <name>A0A1H5SH63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FdrA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49956">
        <property type="protein sequence ID" value="SEF49956"/>
        <property type="gene ID" value="SAMN04489712_101209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ligase_CoA" evidence="1">
        <location>
            <begin position="331"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="481" mass="49160" checksum="F1F85B72145CED79" modified="2017-01-18" version="1">MNSWVEVRSGAYRDSVTLMRVSRTLAERDGVTAAMVAMATELNLDLLTQQGFAVPAGAGPNDLVVAIRGVGEAAVDGARRALDGLLAEVPAPAAPGIAETEPPRTAGAAARRLGEPGGLALVSVPGRYAFVEAMDALTAGLNVMVFSDNVPLHQEVALKEAAGRRGLIVMGPDCGTAVIGGVGLGFANAVRPGPVSLVAASGTGAQQMMCLLDTAGVGVRHVLGVGGRDLSAEVSGRSTLAALAALDADPATELIAVVTKPPAPRVADLVHSAARRLDTPVRFAMLGEDSADLTASTEEVLTTLGRAAPRWPSWPADRRTARPRPGALRGLFAGGTLCAEAALVARRVLGPAFGSGGHRLIDFGDDGYTRGRAHPLIDPTLRLERLAAEAADPACAVLLLDVVLGYGAEPDPAALLAPAVESALERRDDLRIVVSLCGTPADPQDRDRQAAALRAAGADVFVSNAAAARYAAGLARNGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SHT1</accession>
    <name>A0A1H5SHT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mo-co oxidoreductase dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49498">
        <property type="protein sequence ID" value="SEF49498"/>
        <property type="gene ID" value="SAMN04489712_101193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="4">
        <location>
            <begin position="99"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Mo-co_dimer" evidence="5">
        <location>
            <begin position="324"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF49498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="419" mass="46366" checksum="6B90CDD72FB3AC76" modified="2017-01-18" version="1">MEDDLTDEAAYERVRSRQWRELPPLTRRRLLRASAGAGLAMTAAPFAPADPARAAASPIVKPLPPELFINHGTNAEMRWEAMRGQGYLTPADRFFVRNHVATPEIDVRTWRLKLWGSGLRGSPTLDAPVEFGYEDLLAMRAETLTAFIECTGNGRSLFASQQGQQVSGTPWKLGAAGVARWRGVRLSAVLERAGITPQAVDVMPRGLDADYVDKGENMGRVRRPLPVAKALKDVLLAYEMNGRPLPPDHGFPVRVVVPSWVGIASVKWVGDIEVSDQPLFSPWNTRYYRLFGAGHPPEGSAPLTRMGVKSAFELPWDARLPARSERVLHGRSWSGNGRIRQVEVSVDGGATWHRARLRGPRPAHGWTLWEYRWRCPGPGSYQLLARATDETGATQPDATPHNTLGYLFDAVARHPVTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SHY8</accession>
    <name>A0A1H5SHY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent Clp protease ATP-binding subunit ClpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_101219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50229">
        <property type="protein sequence ID" value="SEF50229"/>
        <property type="gene ID" value="SAMN04489712_101219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="37"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="10">
        <location>
            <begin position="446"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF50229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="841" mass="92954" checksum="ED51748FE996DC4F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJ76</accession>
    <name>A0A1H5SJ76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leader peptidase (Prepilin peptidase) / N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50666">
        <property type="protein sequence ID" value="SEF50666"/>
        <property type="gene ID" value="SAMN04489712_101235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="55"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF50666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="20868" checksum="495FC7277AC18F83" modified="2017-01-18" version="1">MDAAPGPGAQAPGGRERFAPVARRPALTAALAVAVVTLLGWRFGPRPELAAFVYFGVVAVLLAVIDAAIKRLPDPLTLPSYPVGAALLGAAAPFTEDGGARYLHALIGMAALWLLYAVQWFLVPGQLGFGDVKLAGVLGLYLGWLGPAAAVAGVLAIHVSSALYALALLLTGRAGPRTQIPFGPFMIAGTLFAVTLYAPGWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SNX6</accession>
    <name>A0A1H5SNX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51457">
        <property type="protein sequence ID" value="SEF51457"/>
        <property type="gene ID" value="SAMN04489712_101266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF51457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23164" checksum="DE5DDA61AA5702C4" modified="2017-01-18" version="1">MLAAVAWVLLGSKLLVVRHVEVSGTHLAPRDRVVAAARITLGLPMVRLDTAAVRDRVQGVREVESARVERVWPGTVRIEVRERVPLVAVERSGRFHQLDRFAMTVVDSARRPASLPLLTVAAPGPDDPATTAALQVVGELPAELSRRLTAVDAPSPESVTLRLGGARPGGADGDPLTVVWGAPGRAAEKARLVDALRRSAAGRAAGTIDVSSPEVVTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SPD6</accession>
    <name>A0A1H5SPD6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Histidinol dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="5 10">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisD</name>
        <name evidence="17" type="ORF">SAMN04489712_101307</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11 16">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5 10"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52466">
        <property type="protein sequence ID" value="SEF52466"/>
        <property type="gene ID" value="SAMN04489712_101307"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SEF52466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="435" mass="45614" checksum="580050F749CAC3C0" modified="2017-01-18" version="1">MISRIDLRGSLPGDLRSVLPRAELDVAAALEKVRPICEDVRHRGSAAVREYTRDLDGVELDALRVPAAAIAEALATLDPAVRDALEESIRRARLVHRDQRRTDVTTQVVPGGTVTERWIPVDRVGLYVPGGRAVYPSSVVMNVVPAQEAGVGSLAVTSPPQPEFGGRPHPAILAACALLGVDEVYAAGGAQAIAMFTYGTEECRPVNLVTGPGNIWVAAAKRHLRGVIGIDSEAGPTEIAILADATADPVHVAADLISQAEHDPLAAAVLVTDSVELAAAVERELAAQVARTKHAGRITEALAGRQSGIVLVDDLEAGLRVVDAYAAEHLEIQTADAHELAGRVRNAGAIFIGAHSPVSLGDYLAGSNHVLPTGGCACHSSGLSVQSFLRGVHVVEYDEPALAQATARVVALAEAEDLPAHGAAMKARFDWEIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SZ75</accession>
    <name>A0A1H5SZ75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55829">
        <property type="protein sequence ID" value="SEF55829"/>
        <property type="gene ID" value="SAMN04489712_101420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="84"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF55829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="21472" checksum="DB30DC89570C1ACA" modified="2017-01-18" version="1">MLVREAMTSPVVTVPPSATVRQAIRVLYEHDITAAPVVDGTGAVIGIVSEMDLMRGEFQADPRAFVLPVAGPHEPPPRLVRDVMITDVRTAQPTSDVAELAQMMLRTAIKSVPVLDDGVLVGMISRRDLMAVLSRGDARIRDDVLASLAELLPKGHSWTAEVHDGVVRLNGPTDPGARHIAETLALTVPGVTRVLLQETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T5B4</accession>
    <name>A0A1H5T5B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58000">
        <property type="protein sequence ID" value="SEF58000"/>
        <property type="gene ID" value="SAMN04489712_101490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="45"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF58000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="16512" checksum="71F04D1ABDCF5684" modified="2017-01-18" version="1">MVPTAPYDTRLREVHMMTTLHAAPAQASLYWRRTFPGDTRQAGAARRFVSCLLDGRPCLDEVVLAVDELVVNALRHTKSGQHGGSFTVEVHAAAGTVTVAVTDQGGPAEPAARDAADTDESGRGLRTVSLTAASWGWHGNEGGRTVTAVFTGERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T7Y4</accession>
    <name>A0A1H5T7Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58925">
        <property type="protein sequence ID" value="SEF58925"/>
        <property type="gene ID" value="SAMN04489712_101518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF58925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="23910" checksum="D11AE3B3DDB8E060" modified="2017-01-18" version="1">MTERSLREQRREQRRALSRDQILDAAEQVFAREGFHQASLREIAELAEFSVGTVYGLFTGKDELYREIFLRRAAEFLPGMRDVLDSGRPPRRQLLDLADWQVGFFRRFPQFGRLVLRGGAIAPPLSEPPDDSRILENFRASQQMQAELFRRGQQAGQLRAGDPMLLARMFSGLVSAFQTAELDAGQPPDGGERLPLAQLHEVLEAAFTLPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TA52</accession>
    <name>A0A1H5TA52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Maleate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59660">
        <property type="protein sequence ID" value="SEF59660"/>
        <property type="gene ID" value="SAMN04489712_101542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF59660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="247" mass="26761" checksum="4584E8A8977C7DEA" modified="2017-01-18" version="1">MTTVLADRCVFGVIVPSTNTVVEDEYYRVRVPGVSFHTGRIMIRNARLDSAQAFERFRNDLSEEIGRAVESVLTCEPDHLVMGMSAETFWGGADGNAEFERMIREMSGLDVTTGASACHAALSALGVRRIGVVTPYQPIADEQVRRFFTELGYHVHAVRGLRCDSATSIAEVGPAEIRAAFAEVDGPDVEALVQAGTNLPVMGVAARLEDELDKPVIAINTATLWHAYRSNGITDRVPGAGRLLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UTR4</accession>
    <name>A0A1H5UTR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TraM recognition site of TraD and TraG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78350">
        <property type="protein sequence ID" value="SEF78350"/>
        <property type="gene ID" value="SAMN04489712_10217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="TraG-D_C" evidence="2">
        <location>
            <begin position="429"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF78350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="610" mass="65548" checksum="7262ACD13C08EC54" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UYN7</accession>
    <name>A0A1H5UYN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80116">
        <property type="protein sequence ID" value="SEF80116"/>
        <property type="gene ID" value="SAMN04489712_10291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF80116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="422" mass="46608" checksum="C38732EF175C94A7" modified="2017-01-18" version="1">MALHPAVADIDLVSMSFWDRPEKERLADFARLREMGAPVFFPEPRIPFVRGGQGFHALVRHADVVAASRDAGTFSSEPAATSPEPPPWLAVLLGTPMINMDDPRHVRLRRIVSRAFSPRMLARIEADVQATATRIVDEVLAEGPRDFVGQVAARLPINVICAMMGIPERTRPYVLRRIDAMTEYAGVRGSLTSPRTLRLLAGNLRAIADLHRLVARLGRARRERPTGDLVSALVNANVDGERLTVRELGSFFDLLLVAGNETTRNALAHGLRLLTENPGQRELLLADFDGRIGGAIEEIVRYVSPIIQFRRTLTRDHVLNGHPFQAGDKVVLFYLAANHDPEAFADPDAFDITRSPNPHVGFGGPGPHLCLGANLARMELRIMFRELFDRLPGLRTVGEPVPLRSSFDNGVKSQPFTFSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V1U5</accession>
    <name>A0A1H5V1U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine/adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81422">
        <property type="protein sequence ID" value="SEF81422"/>
        <property type="gene ID" value="SAMN04489712_102132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="58"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF81422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="454" mass="48639" checksum="6E7B18ED6FE7F20E" modified="2017-01-18" version="1">MRRGVRIAIENAYVVTVAGQEYDGGHILVEDDRIAAVGPGPAPGDGADERIDAAGCLATPGLVNTHHHLYQWASQGLAEDSTLFEWLVTLYRPWSKMDAEVVHGAAAAGLGWLAKSGCTTSTDHHYIFPRGRGDLFAAEVEAAAELHVRFHPCRGSMDRGRSQGGLPPDEVVEDLDTILAETEAAIDRYHDPSSGSMLRVAVAPCSPFSVSKELLVQSAELARRRGVRLHTHLSETLDEEEYCRDRFGMTPVEYMETLGWLGPDVWYAHAVHLHDPDIRTMAGTGTGMAHCPSSNARLGAGIARVADALAAGVPVGLGVDGAASAEMVPLAGEIRQAMYMQRARYGPAALTARQALEMATLGGARCLGRQDEIGTLEPGKLADIALWRVDGFHAALDDPVVALAYGQTPPLARLLVGGRTVVADDTLVTVSQDEVARRGADAHRRLMRLAEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V2K2</accession>
    <name>A0A1H5V2K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted metal-dependent hydrolase, TIM-barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80958">
        <property type="protein sequence ID" value="SEF80958"/>
        <property type="gene ID" value="SAMN04489712_102119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="4"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF80958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="33469" checksum="096876CCD349C63B" modified="2017-01-18" version="1">MTSVDVHQHGWGPGLVKALRRRREPPFLRDWTLYLHGEPPYPVRPADHDPARRARLVRDDGLDRALISLSSPLGVEWLPPDEAEPLLAAYHEDAVALPEPFGAWAAACVREIDPEALGRVLDRGFAGLQLPADALADAAGYRRCAPLLDLLEARGLPLFVHPGPAGQDGREGPGWWAAMVPYAQQMHAAWFAFRAFGRPRHPRLRVCFAMLAGLAPLHGERLAARGGGRGEVDPDTFVETSSYGPRAVDATVRALGVDVIVHGSDRPYASPREPDLGDAARHAFRTANPRRLLTGKEHTDGPRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V4G9</accession>
    <name>A0A1H5V4G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82199">
        <property type="protein sequence ID" value="SEF82199"/>
        <property type="gene ID" value="SAMN04489712_102161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF82199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="14495" checksum="461EF62B5805E5C5" modified="2017-01-18" version="1">MTDVANTGGELNWLLDHLVDSVAHVRNAVVLSNDGLRIASSRGLEREDAERLAAVAASFQSLSRGAGQEFGGGQPRQTIVEMESAFLFVTAAGQGAGLAVLADAEADVGVIAYEMAMLVVRVGRHLAANPRSALAEHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VPT8</accession>
    <name>A0A1H5VPT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88861">
        <property type="protein sequence ID" value="SEF88861"/>
        <property type="gene ID" value="SAMN04489712_102394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="415"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF88861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="508" mass="55391" checksum="7EE81E5C50A5A35E" modified="2017-01-18" version="1">MATGVRFGDRKRTYDELHARATRIAAGLDALGVGPGDRVALVLRNEPAFLEATEAAQLLGALPVPVNWHWRGGELDHLLTDSGARAVFAHTDLVPRVEQSLPAGVPLVEVRVPGELTAAYGLPPNGVTRRHPTLEELIEGNEPWREAAGQAPASVIYTSGTTGKPKGIRRGTTTPEAGLRMALGILEVFGLDPGMRTLIPAPLYHTAPNTHALLAARAGIDLTIMPKFDPEDLLRTVERNRIEHIQMVPTMFVRLLRLPEKVRTRYDLSSLKAVVHAAAPCPVDVKQAMIDWWGPILREYYGGSETGIVTACDSAEWLAHPGTVGRAMWDCDVRILDSEGRRLPPGEPGEVYLRPPSFWTDFTYLGDDAKRRGIERDGYLTVGDVGYLTEDGYLFLCDRAGDMVISGGVNVYPAEIEACLLGLDGVEDVAVFGVPDDEMGEALAAHVAADPAAGLTADTVRDHVRAELAGYKVPKVVVFERSLPREDSGKLFKRRLREPYWAGTGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VZC1</accession>
    <name>A0A1H5VZC1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SAMN04489712_102515</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 17"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92221">
        <property type="protein sequence ID" value="SEF92221"/>
        <property type="gene ID" value="SAMN04489712_102515"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="356"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SEF92221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="436" mass="45614" checksum="D20E193E5B39CB00" modified="2017-01-18" version="1">MKPLRVALLGCGTVGSEVVRLLREQAADLTARVGAPLELAGVAVRRPERAREHVDPGLLTTDAMSLVTRDDVDIVVEVIGGIEPARSLLLAAMKAGKSVVTANKALLAEDGETVFGAAREYGADLYYEAAVAGAIPLLRPLRESLVGDHVKRVIGIVNGTTNYILDQMDTFGASFTDALEEAQSLGYAEADPTADVEGFDAAAKAAILAQLAFHTPVSAADVHREGITEVTAADVAGAKAMNSVVKLLAICERVPDPDGSNGGRGVSVRVYPAMIPRSHPLASVREAYNAVFVEAQSAGSLMFYGAGAGGAPTASAVLGDLVAVARNRVGGTRGPVEVTYAELPVLPMGETVTRYYVQLDVADRSGVLAQVAELFARHDVSIQAVRQEGYGNDAKLVVVTHRAPDAALAATVEGLQRMDIVREVASVMRVEADEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WD37</accession>
    <name>A0A1H5WD37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97385">
        <property type="protein sequence ID" value="SEF97385"/>
        <property type="gene ID" value="SAMN04489712_102675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF97385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="35547" checksum="3C3524D18B7552D0" modified="2017-01-18" version="1">MLDLTRVRILRELKLRGTVGAVAQALGYSPSAVSQQLAQLQREVGVPLVERAGRRLRLTEAGEVLAGHAEALLARAQQAEEETVAASGRVVGAVRVVGYQTALINLLAPVLPGLAERHPELTVEVIDEEFARVLQALVLQEVDIVITDEYSALPRPRRPELTAQHLITEPMRLALPRDHPAAAGDGPVRLADLAGDAWVTGHPGTNHAELLERACVDLAGYRPHIRHRTNDVHVMMALVGQASASCLFPDVGQAERFPGVVVRDLADAELRRHIVVWTRIGAEVRPSVRVVLEALRASAADLTGRFPSLTLMRPRGERDAGTGRERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WEE5</accession>
    <name>A0A1H5WEE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fucose 4-O-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97855">
        <property type="protein sequence ID" value="SEF97855"/>
        <property type="gene ID" value="SAMN04489712_102692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="38"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF97855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="374" mass="41800" checksum="60ECB7AD3C0C4B44" modified="2017-01-18" version="1">MTQILPPRSHRSDGTGGAAASAPQAAPAPAPRKERDPFFDNAKFLAILLVVVGHSIVGLRDVPLAKAAYLAIYMFHMPLFIVVTGYLSRNFTFGSGKARKLIVQLGVPYLVFEFAYSIYDWQVGRNDLEITLLDPYYLTWFLMALFLWRLSTPVWQQIRWPLAIAVGISLLSYMDDLGGDLELHRTLGLLPFYVLGLLLRPEHFEIVKKPAARIFGLVTLGGALAVAFVAAGRMNIDWVYWKHGHDKLGVDNLTGTAMRLAMMLAAVVLIAAFLSLVPRRRTWFTNLGAMTLYAYLLHGFLTRLMKFTSFDDLEFWHTVPGVLTMAAVAVVVGTLLCTPPVVKSMKWLLEPKIGWAFTGLRRPQPARPDRGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XIP6</accession>
    <name>A0A1H5XIP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11270">
        <property type="protein sequence ID" value="SEG11270"/>
        <property type="gene ID" value="SAMN04489712_103260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG11270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="10910" checksum="E3E1CA1CBDC94CEA" modified="2017-01-18" version="1">MQCPKCRGTMRTYDRNGVHIEQCEMCRGIFLDYGELEALTRMQQNYMQAPPPPPAAPAAPAAPAPGWGQQQVHHHHHGGHHPHYRQKSVFHMLFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XJ42</accession>
    <name>A0A1H5XJ42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11246">
        <property type="protein sequence ID" value="SEG11246"/>
        <property type="gene ID" value="SAMN04489712_103259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="90"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG11246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="323" mass="34412" checksum="ED68837F5BCD98FB" modified="2017-01-18" version="1">MRKLPRVSDPATPLAAELVAIGRAAPGGSPDAEPVTLYDRHGVLVIRVGDVVVKAHQADRDNGPLLAVRMAVAARSPGLFLPPLDQPRHVLGRVVTVWPYGEPVSPDAPPWWEAGRLLARLHLTGLSGERAASLPGAEPDGPHPTGALPRWERPVRASQVVARLDVDGREEQVILRAFGTLPAWVRGNAEVPLARNVALVHGDWHLGQLVALPDGTWRLIDVEDLGVGDPAWDLARPAALFSAGVLPGEDWARFLDGYGTGPAMPADGDLWRVLDVPARTLAIQIAATCVISARADRRPLDGFESALVDTCSRITGSGRSPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XL90</accession>
    <name>A0A1H5XL90_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12245">
        <property type="protein sequence ID" value="SEG12245"/>
        <property type="gene ID" value="SAMN04489712_103295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG12245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="28419" checksum="7B545A09C57776BD" modified="2017-01-18" version="1">MSLPEELLELALETAREAGRMLVDKRPVQGPAVVQTKSSPTDVVTQMDRAAEQLIVERIRAARPADAVLGEESGASAGASGVRWVIDPIDGTVNYLYDLPDWSVSIAAEIDGRSVAGVVEIPRRGETCFAVRGGGARMRTAHGERVLRCNTDVPLNRTLVATGFGYEAQRRAHQAQVLTGVLPRVRDIRRGGACSVDLCTLAAGRVDAYYERGVQAWDVAAGALIVEEAGGLVGGLHGAPAGPEFTLAAGPGTFEAMHDLLASLDPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XND8</accession>
    <name>A0A1H5XND8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome bd-I ubiquinol oxidase subunit 2 apoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_103334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13281">
        <property type="protein sequence ID" value="SEG13281"/>
        <property type="gene ID" value="SAMN04489712_103334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG13281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="36510" checksum="F7CE350D734DE616" modified="2017-01-18" version="1">MLAQLLLAVMWVGLTAYVLLAGADFGGGVWDLLAGRATAGRPQRDLIEHSIGPVWEANHVWLIFVLVIMWTGIPPVFAAISSTLYIPLTLAALGIIARGSAFAFRKASTKLWQQRLFGAAFAFSSVFTPFFLGTVTGAIASGRVPPGLARGNLVTSWLNPTSVMTGVLAVCTAAYLAAVYLTHDAKRGDKPDLAEVFRHRALVAGAVTGAMSALGLAVLWLDSPRLFTELTSGWALPFVALSVVAGVASILLLWRRSYVAVRVTAALAVAGLLWGWGVGQYPTLLPGLTLQNAAARNTVLTATLGALAVGALVLVPSLWWLFTLFQRQERGPADAARKGAVGGEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XPD6</accession>
    <name>A0A1H5XPD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable Rubsico expression protein CbbX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13618">
        <property type="protein sequence ID" value="SEG13618"/>
        <property type="gene ID" value="SAMN04489712_103347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000470">
        <property type="entry name" value="CbxX/CfqX_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00820">
        <property type="entry name" value="CBXXCFQX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02880">
        <property type="entry name" value="cbbX_cfxQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="88"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG13618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="322" mass="35838" checksum="73FF4A9D4A9F082D" modified="2017-01-18" version="1">MTERMGFGMRSGVNGSAEAEAPADPPLPADARIDLARERADSQVDEVLDALDTELVGLVPVKTRIREIAALLLVDRARARFGIDSGRPNLHMCFTGSPGTGKTTVAVRLAELLHRLGYIRKGHLVSVTRDDLVGQYVGHTAPKTKEVLKRAMGGVLFIDEAYYLYRAENERDYGQEAIEILLQVMENQRDDLVVVLAGYKDRMDSFFSSNPGMSSRIAHHIDFPDYTGEELEAIGRLMLAREGYALAPETEPVFHDYLERRRARPRFANARSVRNAIERARLRHANRLIAEGGRVGRAELTILQPDDFLASRVFTEKAAPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XQL8</accession>
    <name>A0A1H5XQL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13962">
        <property type="protein sequence ID" value="SEG13962"/>
        <property type="gene ID" value="SAMN04489712_103361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021412">
        <property type="entry name" value="DUF3052"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11253">
        <property type="entry name" value="DUF3052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG13962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="15386" checksum="661A307B680AA88B" modified="2017-01-18" version="1">MSATAGQAQSERSLAERLGFKASQVVQEIGYDDDCDEELRRSIEAVIGGELVDEDYEDVVDVVVLWWRDEDGDLVDGLVEARTSLADGGHIWLLTPKVGREGHVEPSDIGESAPTAGLSQTSSMSAAQDWSGTRLVAPKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XUZ4</accession>
    <name>A0A1H5XUZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-threonine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15551">
        <property type="protein sequence ID" value="SEG15551"/>
        <property type="gene ID" value="SAMN04489712_103422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="24"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG15551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="31847" checksum="66342FB981A36891" modified="2017-01-18" version="1">MTEHLTGIRPVLDDVLAAADRIAPYARRTPVLSTRIDGRPVAFKLEHLQVTGSFKFRGALNVLTADRDVRHVVAASGGNHGLGVAEAARLRGLPARIYVPHGTPEAKIRRIVAAGAQVIRHGERYAEAEAAARAEAAASGAGFLHAYDDPGVIAGQGTVGLEIVEQVPGCDTVAVAVGGSGLAAGVSLVLGPGRTLVAVEPERCNALHAAFAAGEPVEAPADSIAASALGASRVGELPFGILRERRVRSVLVGDEQIASARDRLWEELRLAVEPAAAAPFAAWLAGQVPGEHPCLVLCGANTDWRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XWX3</accession>
    <name>A0A1H5XWX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16035">
        <property type="protein sequence ID" value="SEG16035"/>
        <property type="gene ID" value="SAMN04489712_103440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG16035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="28460" checksum="23D79CFA4A0FC73D" modified="2017-01-18" version="1">MNAKTETTTRIGGTVLIVLPPSEGKACGGDGPPLDPAGLSFPELNPIRERVLSALAEVCGRDDAPQVLALPRTQAEEALRRNRDLHTAPTLPVSRLYKGVLYENLALASLDEAARRAADEQIVILSGLWGALRLTDRIPPYRLAMAVSLPPLGRLAALWRPALEQALRPTGLVVDMRSAPYAVAWRPAAPTVTVRVFREFHVPGGVPKRTVVSHMAKATRGKVAHDLLKAGVDPASPEELLKAVCGLGYSAELSGDGRHLDVVLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y217</accession>
    <name>A0A1H5Y217_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG18064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG18064">
        <property type="protein sequence ID" value="SEG18064"/>
        <property type="gene ID" value="SAMN04489712_103520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290081" evidence="2">
        <location>
            <begin position="38"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG18064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="470" mass="48057" checksum="F71CE65E50C2DD6B" modified="2017-01-18" version="1">MRISVSCTSRGALRTAALGAIVVAAGMLPGALPAAGAQTADASLAYSCRFPQGARQVKVKVAGEFPSSARVGRPLRPGKMNVTVTVPQAALGDLSGLGAATVTGTAGFVTMITQGTGPSPVRWPGLAVKPAAVPRGGDLVLTASGPVPAVKVGKPGPVIFTLGQLALDLKPRKADGSATSPDALAVPCTLNPGQNSTLATVFASPDGSGPGRQDRPERGNLRQGPSPDRSLAAADIPADCEELGEDIGDPFALTVCAYMTGYSNVKKLNSAMLFPYTIINIVGTTFYDCSPPGKIRFCIPFKARLNSGGKAGFPPARSTFLTYGFMPTTATVEVTQATPFMDILVELDFILDDEDGDSSRVTATAKFGMRVHEAEVNGTPLDVGPNCGLAEPMETKLSATAAEYSPDSGGPLAGEATIPPFAGCGVGEDLDPIFTASISGPGNYVKMTQGNGCTAQSGFGCPPVKPVPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YHL9</accession>
    <name>A0A1H5YHL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23603">
        <property type="protein sequence ID" value="SEG23603"/>
        <property type="gene ID" value="SAMN04489712_10420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="180" mass="20171" checksum="479362C0B80DE0C8" modified="2017-01-18" version="1">MTAGGHGGADELDFWSFIRLAQHRLAEEHGFGDRLATELLLTLNRASGIVTYDLEAAVHRPRGRSWSGFRLLFVVWLAGPLEAKKAAELTGMSRAAVSGLAKTLVGQGLLDRTPGERDGRSVLLSLTERGRREMLETFQAQHRREQEWAGVLTEAEQRILIMLLDKLITNRDQFDVRGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YM39</accession>
    <name>A0A1H5YM39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24810">
        <property type="protein sequence ID" value="SEG24810"/>
        <property type="gene ID" value="SAMN04489712_10473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="11"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG24810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="149" mass="15786" checksum="0DE4B510194609DA" modified="2017-01-18" version="1">MTTSTLAIGPSRAPTPQRPEHTLVALHGELDLATTAVLRERLLATLHHGTRLLIIDLSGVSFCDAAGLTVLLGTQRRAAGLGITLSLAAPNPQVAKLLRITGLDRSLTVHPTLHDALASPPTRLPALTVERRPAGNAHRFDRPSPTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YS85</accession>
    <name>A0A1H5YS85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA helicase HerA, contains HAS-barrel and ATPase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26670">
        <property type="protein sequence ID" value="SEG26670"/>
        <property type="gene ID" value="SAMN04489712_104144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="393"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG26670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="808" mass="86815" checksum="A8F35AF854680796" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXN4</accession>
    <name>A0A1H5YXN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28570">
        <property type="protein sequence ID" value="SEG28570"/>
        <property type="gene ID" value="SAMN04489712_104228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291023" evidence="1">
        <location>
            <begin position="33"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG28570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="39668" checksum="177120EDEFAC22F5" modified="2017-01-18" version="1">MSRSRKSWAGTCLAVAVAGGVTVGLVPGTAVAAQGAPSLQVIAGKLNNPRGITVLGDGTILVAESGTGGKGPCVGSGEGRQCFGATGSVYRVKGAKKGRVVTGLPSVGGPGEAIGPVDVAVSGKDYIVLNGFGGGTAQRAKFGSKARRMGTLYRVRGGKIYGDLVAHETRLDPDWVLPRTDPGEPSVNANPWRFASAAGGVYVTDAGGNDLLRVSGGKTYTEAIFPHNEIAPAPKTAAASPQARQLLRAIAGPGEAVQGGIPVQSVPTGVVKGPDGALYVGELGGFAPGASRIWRIVPGHRPKVFASGLTAVADLALDGRGNLVALTMTTGFGQNGPQPGALYRINLKTKAKSEIPTGGKLLFPTGLGVGPKGQIYVANNGIGSGAGQLVRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z5K4</accession>
    <name>A0A1H5Z5K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein, gntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31290">
        <property type="protein sequence ID" value="SEG31290"/>
        <property type="gene ID" value="SAMN04489712_104350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG31290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="15102" checksum="6D5DDA7D34E767E9" modified="2017-01-18" version="1">MGRYAADMGKREPTDRRKVYVRIADELRADIAAGRHQVGEPFPSIATLRERFGVAGATIERALTVLREEGLIMSRQGSPSVVIARPGDEEAGDAPHEPSQEFTLIWNQLQEIREHLRQQNLRLDELEERTKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z946</accession>
    <name>A0A1H5Z946_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32861">
        <property type="protein sequence ID" value="SEG32861"/>
        <property type="gene ID" value="SAMN04489712_104429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG32861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="16260" checksum="C5E8F070FB2EF5AB" modified="2017-01-18" version="1">MTPPDPGMRASDADRDRVAESLREHCAVGRITVDELQERLEAVYVSKTFGELSRVTADLPEEDLYERPVPARGAASATVAKRPQGELAQRGMRAVWATWAMVSAINFTVWLALALTGEVVYPWWIWVAGPWGAVLLAGTLFGGRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZEZ4</accession>
    <name>A0A1H5ZEZ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">SAMN04489712_104527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35008">
        <property type="protein sequence ID" value="SEG35008"/>
        <property type="gene ID" value="SAMN04489712_104527"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="123"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG35008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="29442" checksum="0D66F6042BC19ABB" modified="2017-01-18" version="1">MTAQILDGKATAAEIRNDLKARVAALRDRGIAVGLGTVLVGDDPGSHAYVGMKHRDCAEVGIRSIRRDLPADATQEQVEQAVAELNADPDCTGYIVQLPLPKGLDEKRVLELIDPDKDADGLHPFNLGRLVLMQPGPLPCTPKGIVALLRRFDVPLRGAEVVVIGRGVTAGRPLGLLLTRRSENATVTLCHTGTKDLAAHTRKADIIVAAAGVPALITADMVKPGAAVLDVGVSRVNGKLTGDVAPDVAEIAGWVAPNPGGVGPMTRAMLLANVVEAAEATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZW44</accession>
    <name>A0A1H5ZW44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40718">
        <property type="protein sequence ID" value="SEG40718"/>
        <property type="gene ID" value="SAMN04489712_10547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014543">
        <property type="entry name" value="UCP028291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09981">
        <property type="entry name" value="DUF2218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028291">
        <property type="entry name" value="UCP028291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG40718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="101" mass="10921" checksum="C5744B05C847F70E" modified="2017-01-18" version="1">MIESTARVTTDRPARYIKQLCDHLGRRVTTTVEGDTGHVALPEGAGACDLRAEDGVLVMTATAPDAEGLARVEDVVGRHLERFGTRESLTVSWIRTTAEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZY40</accession>
    <name>A0A1H5ZY40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Farnesyl-diphosphate farnesyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis; phytoene biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40894">
        <property type="protein sequence ID" value="SEG40894"/>
        <property type="gene ID" value="SAMN04489712_10555"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00799"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017828">
        <property type="entry name" value="SQ_synth_HpnD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03465">
        <property type="entry name" value="HpnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG40894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="295" mass="32445" checksum="AB55EB35FA0F3ADC" modified="2017-01-18" version="1">MTVPSAYQHCEQIVRGQARNFCYGIMLMPPPKRRALSAVYAFARRIDDIGDGDEPAERRLVLLAQARWQLEAVRNVSHGCAGTGDLDGDPVLVALADAATRHPIPLSAFAELIDGCESDVRGAEYATFEDLLQYCRRVAGSVGRLSLGVFGAARPREAAPLADALGVALQLTNILRDLREDRAGGRVYLPAEDLARFGCTLDLDGAGRFTDPPDRLRELVRFEATRARAWYETGLRLLPMLDRRSAACTGAMAGIYRRLLERIADRPETALHARMSLPTWQKAMVATRALTGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A647</accession>
    <name>A0A1H6A647_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leader peptidase (Prepilin peptidase) / N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43507">
        <property type="protein sequence ID" value="SEG43507"/>
        <property type="gene ID" value="SAMN04489712_105200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="67"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG43507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="213" mass="22442" checksum="04E6F53445664862" modified="2017-01-18" version="1">MIQFLTLSVAGLAGSGAGWFSAPLTTRYCGPVTRHRRIVLAALGGAVTVMLTWRLGMGVELLAFCYLGVVGSLLAVIDIAVKRLPDFFTLPSYGVGIVLLGMAAFFVADGMFRFVHALLGMAALWFCYAVQHYLRPDAMGRGDVKLAGVIGLHLGWLGQAEWVTGAMAGLLLGGLFGITCMLLGRVGRKDEMPFGPFMLAGALLGVMSGGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A6A5</accession>
    <name>A0A1H6A6A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43567">
        <property type="protein sequence ID" value="SEG43567"/>
        <property type="gene ID" value="SAMN04489712_105204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="200"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG43567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="43274" checksum="0787982ED8950629" modified="2017-01-18" version="1">MSARTGVAGGSAGLRINAAFRLLMQIRMSIAGITLLLLSTGRLSVAAFVTLVCVGLLAWLVARYVTEIVPRLLAHPSLVLLDVAASFTVLAVCGPAGPFFLSTVATAAAAGLLYRWPGMLGVSAAQIACYYLTFAFDAAQTEDTGSFQVLVGQPAYYPLVGFAGVALRRIFEEQSVQEEARIRAEVAAAAAEERARLAREMHDSLAKTLRGIALAAAALPAWARRDPARAAEEAVRIATATEVASREARGLLTELRDTTVTRPLAEAVRAAADRWQAETGIEVRCALAPDTDVPLRTRYEALAVLTEALTNTARHAEAGLVTVSLAEEDGQVVLTIRDDGRGFHPEELPDLARQGHYGLIGMRERAERVGGTVTVQAVPGAGTTVELRLPARHRGERFDNRLAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A7Q4</accession>
    <name>A0A1H6A7Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44758">
        <property type="protein sequence ID" value="SEG44758"/>
        <property type="gene ID" value="SAMN04489712_105269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="502" mass="54215" checksum="C4C198ED228CA324" modified="2017-01-18" version="1">MQGRPGPCGCGCALTPATSLGFSAVDFARDVLGIEPLPWQRWLLIHALELRPDGRFRYRTVLILVARQNGKTSLVEIKNLWKMYVLQVPLVIGTAQQLDKAEESWNKAVEIVESIPELKAEIKHIDKTNGKKALSLVGGPRWKIETASRRGGRGLSGDDVNLDELREHQHWDAWGAVTKTTMARPNAQVWAFSNAGDDRSVVLNDLQAKGRAAAGNPDAADLTLGFFEWSAPDEVACTCGRPEGVHAVDCALADRRYWAMANPSLGYTITEEALASALATDPDPVYRTECLCQRVPDLQPDWAVIGERAWSVLVTDPPDPAGLKPVAFAVDVNPERSHAAVGVAGRLGGLLYVEVAAYERGTDWVPAWLTERSGAWGPCAVVVDRNGPAGSLIADIEAAGVTVRTPSGNEVAQACGALYDAVVRPPDAPEDWAPRLRHPGQEELDDAVRRAARKDLGDGAWKWARTTSTADISPLVAVTLAAWGQVKFAGPAADYDVAESIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABD0</accession>
    <name>A0A1H6ABD0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fumC</name>
        <name evidence="5" type="ORF">SAMN04489712_105313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45610">
        <property type="protein sequence ID" value="SEG45610"/>
        <property type="gene ID" value="SAMN04489712_105313"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="14"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="404"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="320"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG45610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="466" mass="49134" checksum="9A823DEC08CBFDDD" modified="2017-01-18" version="1">MTEQGYRVERDSMGEVRVPAGARWRAQTQRAVENFPISGRPLEPAQIAALGRIKAAAAEVNAELGVLDADVAAAIAAAAREVAAGAWDEHFPVDVFQTGSGTSSNMNANEVIATLAAERLGRPVHPNDDVNASQSSNDVFPSAIHIAATEGVVRELVPALGHLAAALERKAAEFRDVVKAGRTHLMDATPVTLGQEFGGYAAQMRYGVQRLEGVLPRVAELPLGGTAVGTGINTPPGFAARVIAVIAQETGLPLTEARDHFEAQGARDALVELSGVLRTVAVGLNKIANDLRWMGSGPTAGLAEIRLPDLQPGSSIMPGKVNPVICEAVLQVAAQVIGNDAAVAFGGAAGNFELNVMLPMLARNVLESVRLLAAASRLLADRCVDGIEADAERCRTYAESSPSIVTPLNRHLGYEEAAAIAKQALREHKTIRQVVLERGHVDQGRLTLEQLDAALDVLAMTGRRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABJ9</accession>
    <name>A0A1H6ABJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45831">
        <property type="protein sequence ID" value="SEG45831"/>
        <property type="gene ID" value="SAMN04489712_105326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG45831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="10810" checksum="24C44E2FED6A9D32" modified="2017-01-18" version="1">MSVALLLAEPGNDFPLNDDTVSPGLLGFAVFAALCVAVFLLIRSMNRQMRKIQAPRQADLDQEAWERNRAAEPAKAAEPAGTAKAGKAAGQADRDSGDDGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADJ0</accession>
    <name>A0A1H6ADJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe/B12 periplasmic-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46442">
        <property type="protein sequence ID" value="SEG46442"/>
        <property type="gene ID" value="SAMN04489712_105364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="27941" checksum="8624340A1506A0A8" modified="2017-01-18" version="1">MLRDDTGAEVPVPDRVRRVVSLVPSLTETVAATDPGLLVGATDWCSHPAGLEVTRVRGTKNPDVELVRALRPDVVLANEEENRAPDLAALREAGLPVWVTVIRTVDQALASLRRLLTGACRLPVPSWLEEAERVWAALPEPERRRGAVIPVWRRPWMVVGRDTFAGDVLARLGVDNLYAGHAERYPRIGVGALVAARPDLVVLPDEPYRFTAEDGPESFPQIACALVSGRHLTWYGPSLVTAPQVLRAQLAQEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B0W0</accession>
    <name>A0A1H6B0W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54272">
        <property type="protein sequence ID" value="SEG54272"/>
        <property type="gene ID" value="SAMN04489712_106147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="PTHR10605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG54272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="34308" checksum="1351342725FBDDB2" modified="2017-01-18" version="1">MALPDVLVIGAPKAGTTALHSGLARHPRLFMSPVKEPKFFLTDGPPPTRGGPGDAQTYREHVWRRADYEALFDGAPPGALCGESTPFYLHDLEAQLRIRRLIPDVRLIAVLRDPVERAHSNWAHLWSAGLEPIGDVVEACAAEEQRVRAGWAAFWRYTGLGRYGEQLQHLFKLFPREQVLLLRYREVRDTPRATLDRICAFLGVETGLISTIPAENVTRHVSDSPANRALQVLLRGGASLGRYMPEAVRQTARRPFLSLLQRDPRLRRPPAPEQRERLLPYFEDDIALFQELTGWDCADWLKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B1A5</accession>
    <name>A0A1H6B1A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD domain-containing protein, G-beta repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_106131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54017">
        <property type="protein sequence ID" value="SEG54017"/>
        <property type="gene ID" value="SAMN04489712_106131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="PTHR19865"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="604"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="650"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="696"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="741"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="786"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="831"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="941"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="1300"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="1532"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="523"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG54017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1835" mass="197293" checksum="879731F2F31582B5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BII7</accession>
    <name>A0A1H6BII7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60016">
        <property type="protein sequence ID" value="SEG60016"/>
        <property type="gene ID" value="SAMN04489712_107104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293739" evidence="2">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG60016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="15233" checksum="1B532A6EDAFD1C89" modified="2017-01-18" version="1" fragment="single">MTPALTRRSARRAIVGTLTGLVLALSGLVAAGPAAADVPGVDEIVKSPNMQHLANIPKQGTFASEAALNSDLAFQGDYAFAGNYNGFTVYNIAKPGEPSVVTQVNCVGSQNDISVSGNLLFLSTDSSRSDDSCQSTSKPVTDPTAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLJ8</accession>
    <name>A0A1H6BLJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61601">
        <property type="protein sequence ID" value="SEG61601"/>
        <property type="gene ID" value="SAMN04489712_107227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG61601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="333" mass="34553" checksum="ED29391EB9455BD8" modified="2017-01-18" version="1">MTTTTHAVPQAPAAPRDRRRIRTARLAACYLTIAACVPYLTLKIAWLGGGTVGWKDPAEAEGSALYVANAITLGMDALAAVVALTFTYRWGRHVPAWLVLTPIWVGVGLLAPIALSAMPVVVIESLTGPAGVGGSEAGLEGWVYAMVYGGFTLQAAGLAAAFTLYARDRWADLFRLGTAELAQGRTRPLQAVLAVAAAVLVAGYAAVQLYWAFGGTAGIAEESAAVRTATASLVNGVWAVMALAGAGGLLTLVYRRGSGPLWRPLAAAWVGSGSVFAWSLYGLVVVLGQPGGLGEQSTVLNDYTLLFGLLAGLLMGLTGAVLLTDREETGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C831</accession>
    <name>A0A1H6C831_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multisubunit sodium/proton antiporter, MrpC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69140">
        <property type="protein sequence ID" value="SEG69140"/>
        <property type="gene ID" value="SAMN04489712_10954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG69140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="14722" checksum="D10C2535EA0449E0" modified="2017-01-18" version="1">MSLVLLVVVGVLFSIGFYLLMQRSLIRIVVGFVLLGHAANLGLLLAGGPAGAPPLLGRHLPGGERMTDPLPQAMALTAIVITFGVTAFLLALAYRSWLFLDEDKVQDDVEDRRVNAEARRGAGDEYASHEVAEEDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8P5</accession>
    <name>A0A1H6C8P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69350">
        <property type="protein sequence ID" value="SEG69350"/>
        <property type="gene ID" value="SAMN04489712_10975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG69350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="445" mass="47164" checksum="E8EE567582CE96FB" modified="2017-01-18" version="1">MADYRRVADEVAADITAGRLRPGDRLPTQREFARRRGIAASTAARVYGELTRRGLTVGEVGRGTFVRATARQPGPALAEPADSMIDLELSHCVVPGQAELLAGGLGALLRPDVLESAMRPIGVDGTPLARSLVADLLARGDWRPDPARVLFAGNGRQAIAAAVSALVPPGARLGAEELTYPVLKAIAGRLGVTVVPLAVDEAGLVPEAVEAAMRKAPLKAIYLQPTLHNPLSLTMPEQRRAELAGVLERLNIFAIEDVIWSFLRDDLPHLAALAPEHTLVIDSLSKRLAPGLTLGFAVVPQAAAPNMATALRSGGSTPMRLALDAATRWLTDGVLRSVTRAKQREAAVRQEIAARHLGEFAVHGDPRSFYCWWELPSPWRADTFVAAAARRGIAVTPGAAFTVGRYRAPNAVRLGLASPPAETLSHALATLAGLARSAPDDLVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9J6</accession>
    <name>A0A1H6C9J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69644">
        <property type="protein sequence ID" value="SEG69644"/>
        <property type="gene ID" value="SAMN04489712_109104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="15752" checksum="0BFE7083CB8EB734" modified="2017-01-18" version="1">MLERWRVRPAVRLAGLCHAFYGTDGFATALGETSRRAELVACIGEEAENLVYFYASCDRASSYPELARGGPFRDRFSGERSDPPPAARRDFAELTVANELDLVEINPEFRERYGPGLRDLFTSWDALLGDAARHAVRTVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CI88</accession>
    <name>A0A1H6CI88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72622">
        <property type="protein sequence ID" value="SEG72622"/>
        <property type="gene ID" value="SAMN04489712_11020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG72622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="20974" checksum="77F9A8AA516190BC" modified="2017-01-18" version="1">MAPARAVSRPPGQLDDEAIVAASLEEPEAFGELFRRHSPRLHAYVQRRLGPALADDVVAETFATAFRQRARFDGRAAFGAWLWGIASKVIARHHRQESRMYRAFARTGVDPAVDGVAELASARAAATALGPHLAKALAGLKAQDRNAVLLLAWADLSYAEIAVALDLPLGTVKAKIHRARAKLRKALPEETNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJ47</accession>
    <name>A0A1H6CJ47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72745">
        <property type="protein sequence ID" value="SEG72745"/>
        <property type="gene ID" value="SAMN04489712_11031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017255">
        <property type="entry name" value="AcTrfase_GNAT_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037663">
        <property type="entry name" value="Acetyltransf_GNAT_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG72745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="17009" checksum="F144840BA5CFF0D5" modified="2017-01-18" version="1">MTFREAVRDDVPAIVRLLADDPLGSTRESPGDELPEPYWTAFDAIDKDPNNAIIVAEIDGRIAGSLQLTYIPGLTYTGGERAQIEGVRVASEHRGRGVGQALIEWVIEQARARGCRVVQLTTDRQRPNAIRFYQKMGFRPSHMGMKYPLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJ85</accession>
    <name>A0A1H6CJ85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73034">
        <property type="protein sequence ID" value="SEG73034"/>
        <property type="gene ID" value="SAMN04489712_11063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG73034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="30967" checksum="459C5BD560159555" modified="2017-01-18" version="1">MTHPTISASGLSLSYRGTRAVDEVSLRLERGVTGLLGPNGAGKTTLLRILATATPPDRGALTLLGHDPSTVRGRLQARRELGYLPQNPGFHSGFTAFEFVDYVAILKEHTDRRARHAEVRRVLDEVGLAEVRGRRIRALSGGMRQRVALAAALVGDPGFLVLDEPTVGLDPEQRMRFRELIAAAGEGRTVLLSTHQTEDVAMLCHRVVVMDKGRVRFDGTPGELVARARGRVWASPERSPEALAGWRTGTGEFRNVGDPPAGARLLEPTLEDGYLLTLDGASEVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZZ1</accession>
    <name>A0A1H6CZZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78135">
        <property type="protein sequence ID" value="SEG78135"/>
        <property type="gene ID" value="SAMN04489712_11234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG78135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="114" mass="12163" checksum="9B570799CE1A4758" modified="2017-01-18" version="1">MAQYGIFVYQPAPADPMNLPAEYEKALETYPAQVAETGAEPVTGFAFQPSTTATSVRGDEISDGTFHPAKEVLAGFFVIEAPDLDVAVKVAKLNPATRHGGGVEIRPLFTPPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D034</accession>
    <name>A0A1H6D034_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78652">
        <property type="protein sequence ID" value="SEG78652"/>
        <property type="gene ID" value="SAMN04489712_112106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="15828" checksum="591721CC5789A902" modified="2017-01-18" version="1">MLTGVSHMGFTVADISAAAAFYERLLGGPPEVRRIYDAPYTADQVGYPGARLDIAIFRIPGSDVRLELIQYLEPAGTPVDIETKNPGTAHLCLVTDDLATEFARLTSLGARPRSAAPVMITSGPNQGRRVAYFRDPQGLTIEIVEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5P9</accession>
    <name>A0A1H6D5P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)H-flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_113122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80650">
        <property type="protein sequence ID" value="SEG80650"/>
        <property type="gene ID" value="SAMN04489712_113122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="277" mass="28739" checksum="2D3C8631FBA73A4D" modified="2017-01-18" version="1">MPDDERASGMRARPYRVLARYPLTAGMVSLVLTPLEADAPVPRALPGQYWVLQTEAGVRVAAVTGGASCDLEVTTLRVPCGGPLGEPGTVLAVHGPFGTGWDLAAAAGRTLLLVAWEAGLAALRPVLDQVLSGTARYTGTKLWAGGRTPESLPLHSDADLWVARGMDVTIAAGSGLSMAGVVQDLPSLPPDTVAMLAGPMPMMMEAAHALAGHGLAAHRIQLSAHSLIRCTDAVCGGCRVGPRATGSGDLALLACRNGPVFGYDELTARPPRNRFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8L1</accession>
    <name>A0A1H6D8L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tn3 transposase DDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_114138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81767">
        <property type="protein sequence ID" value="SEG81767"/>
        <property type="gene ID" value="SAMN04489712_114138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002513">
        <property type="entry name" value="Tn3_Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01526">
        <property type="entry name" value="DDE_Tnp_Tn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DDE_Tnp_Tn3" evidence="6">
        <location>
            <begin position="44"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG81767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="28481" checksum="84F51E9C8D57C9C5" modified="2017-01-18" version="1">MRVITRAGKPWVSVPKLDKLPEPKNPGALKAEVQRRWGTIDLLDILKDIAFITGFPDAFTSVATREVLDKATLNRRLLLVLFALGTNMGIRQMAATGEHGQDEAALRRVRATYVTRENLREAIVTVVNATLKAREPTWWGTATSTASDSKRFASWDSNLMTEFHARYGGHGVMIYWHVDKGRLCVYSQLKSCSSSEVAAMIEGLLRHGTDADIEANYTDRRARCCRAPGGAGMGKVSAWLPWLPAVPGAPLSACRRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8P8</accession>
    <name>A0A1H6D8P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tn3 transposase DDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_114104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81639">
        <property type="protein sequence ID" value="SEG81639"/>
        <property type="gene ID" value="SAMN04489712_114104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002513">
        <property type="entry name" value="Tn3_Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01526">
        <property type="entry name" value="DDE_Tnp_Tn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DDE_Tnp_Tn3" evidence="6">
        <location>
            <begin position="243"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG81639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="483" mass="50625" checksum="B35E71A71774C9F6" modified="2017-01-18" version="1">MALRGLLRVPEDRRVPELERLRTSPVKASGRVLVRELDRVAEIGGLGAGRVETEPVPAVTLASLAQYGIASKAPMLRDLEERRQTATLLATVRHLQTASIDDTLDLLDLLARAERAGKAAFTLCAVMHLHTALRRRDVFAAGADRWSDPRARLLEGAGWEAARPGVLAALELGEEPAGHLAELASALEGAYTRVLDGLGGNTSVQFVGGRLQVEKLGPLAEPPLMGEFRALIDGMLPRVNFPELLLEVFDRTRLAADFTHISGADTAMEDFAVSLCGLLVAEVCNVGLIPVEKPNVPALTRARLQQVDQGYLCAETISAANAQLIAAQAGIDIVNCWGGGQIASADGLRFVVPVANLHIGAEHVAGQAFPGVGGGVGRRGSRRRRSGGVELGGLGGGVAEVEADRFDGDAGVDESGPPAVVVCRGRGSYWPVLTLRTDRLIARLGAAERAGDEGGDGLLEGGGEVHAEGGEGGVFRVGLEHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DB02</accession>
    <name>A0A1H6DB02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid exporter, AAE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82399">
        <property type="protein sequence ID" value="SEG82399"/>
        <property type="gene ID" value="SAMN04489712_11520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG82399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="40819" checksum="9033D40D289D475F" modified="2017-01-18" version="1">MYLGAVLGTGVIALPALAAEVAGPASLLAWLALVVLSAPLAATFAALGARHPDAGGVSTHARLAFGERAAAVVGWCFYLAIPPGAAAAALFGGGYAAATLGGGDATAAVTAAVLMGVVTVANALGLRVTGRLQVTLAVLLVMLLLSSVALSLPHARVDNLQPFAPHGWAAIGPAALLLVWSFAGWEAVTYLAAEFRRPARDLPRATGAAVVLVGVLYLSVAFAVVAVLGPAAARTDAPLGELMATGLGGGARTLAAVAALLLTLGTMNAYYAGAAKLGAALGRDGALPAWLAQGSTAGEAPRRSLTAVSGLAFAALLAVVLADVGTRPLVLLTTGSFVTVYAVGVAAALRLLPRWSKPHLTALTALIGVILLLAMSGAYLIWPLLVTVGALLYHHLHRRHRDPAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DB40</accession>
    <name>A0A1H6DB40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82480">
        <property type="protein sequence ID" value="SEG82480"/>
        <property type="gene ID" value="SAMN04489712_11532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295699" evidence="2">
        <location>
            <begin position="26"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="227" mass="24775" checksum="B5C064AFC636BEF7" modified="2017-01-18" version="1">MRIRSVPPMVALASSLLLLPSCGSADQDDAGGKEPRTGEKISLTEEFKKARNQAKTDFERGIWDRAIKAGKISQADYEESFGRYRQCAQDAGYRETYTKQSNGTYRINPPSLPDDKSLDQYLKTTGDCAEAAGLTRVEALLRTQVDNPDRLADPREVVVRCLLKEGLISGDYTAEQLGKDAKDGFRKVPFDLADPRVKQCLDKGGYAVEVQGPRNGPGAGPEQTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCT3</accession>
    <name>A0A1H6DCT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_115142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83088">
        <property type="protein sequence ID" value="SEG83088"/>
        <property type="gene ID" value="SAMN04489712_115142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="68"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="430" mass="47085" checksum="5814E1D8135763FA" modified="2017-01-18" version="1">MHQHSRTDPYADRYADRAAGMVASEIRALFAVASRPEVVSLAGGMPNIAALPLDVIGGMLDELTRRRGAEALQYASAQGDPELRARICEVMALEGVHGSPDDVIVTVGSQQALDLLTRIFVDPGDVVLAEAPSYVGALGTFAMYQADVVHVPLDSEGLVPAALRETLERLRREGRRVKFLYTVPTFQNPAGVTLTAARRAELLDICAAHGVLVIEDNPYGLLGFDGEPMRALRADDPDHVIYLGSFSKTFAPGFRIGWALAPHAVRAKLVLAAESAILSHASFSQFAVREYLMTQPWHQQIKSFREMYRERRDAMLDALESMMPAGCTWTRPAGGFFVWLTLPEGLDAKAMAPRAIADRVAYVPGTGFYADGQGRRNMRLSYCYPEPDRIREGVRRLASVVEREIELRDTFGTGRAPERSGVDTPGPDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDW4</accession>
    <name>A0A1H6DDW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83558">
        <property type="protein sequence ID" value="SEG83558"/>
        <property type="gene ID" value="SAMN04489712_11622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG83558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="15038" checksum="610FBA01B9B16ABE" modified="2017-01-18" version="1">MALLARDGRMSFTDLAKETGLSVSAVHQRVRRLQKRGVIKGFAARLDAEQIGLPMTAFVSIKPIDPAAPDDAPERLAHLPAIEACHSVAGEESYILKVRVATPNELEDLLQKIRAAANVSTRTTVVLSTPYEDRPPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE75</accession>
    <name>A0A1H6DE75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_115124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83013">
        <property type="protein sequence ID" value="SEG83013"/>
        <property type="gene ID" value="SAMN04489712_115124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="3">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG83013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="23846" checksum="20CA36744EC2135B" modified="2017-01-18" version="1">MAGRKGSGVLELAVLGLLHEAPMHGYELRKRLNTLLGMFRAFSYGSLYPCLKQLLAQGLLVEDRPEGPDVALTLQSRRSKIVYKLTAEGKERLQQLLTEAGPAAWEDEGFGVRFAFFRHTDADVRLRILEGRRSRLEERLESVRAALARTRERVDSYTLELHSHGLESVEREVRWLNELIGRERAEQESRRAAREKSSGKSADNTTDGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DES9</accession>
    <name>A0A1H6DES9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_115139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83076">
        <property type="protein sequence ID" value="SEG83076"/>
        <property type="gene ID" value="SAMN04489712_115139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="439" mass="46266" checksum="AD2BC792DF79C4F0" modified="2017-01-18" version="1">MGDVTGGPYAGRVRLAELRAVVGGRDFRWLYATRLVSQMTDGLFQVALAGYILFSPERNTSASQVAAAFAVVLLPYSVLGPFAGVFIDRWSRRQILLWAPVLRGGLVAGTAALLLAGHEGVGFYLAVLVVMGVNRFFLSALSAALPHVVRRDLLVTANAFSVTSGTVISFAGGGIGYLLRLAFGGGRGGAAAILLCAAGCYLLVGLVATTLDRGRLGPDLDEAPPQTREALGNVLRGLTDGARRIRRDRPVALALTAIAFHRFCYGITLIMTLLLYRYLFSSDVEEGLDRAALVLGVSGLGFLLAAVITPPVVRRIGKNAWIIVLLGSAAVLLAVFGLPFADLPWLALAFGLGVVSQGVKLSVDTILQERVADAYRGRVFAVYDMLFNATFVGAAALAAASLPANGRSPAMLLVLVTAYAVGATAYWTSSVRIGKPARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFK1</accession>
    <name>A0A1H6DFK1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PepX_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_116123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84001">
        <property type="protein sequence ID" value="SEG84001"/>
        <property type="gene ID" value="SAMN04489712_116123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="307"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="549" mass="60824" checksum="C7F8FC1FC5617F63" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHS8</accession>
    <name>A0A1H6DHS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Erythromycin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84744">
        <property type="protein sequence ID" value="SEG84744"/>
        <property type="gene ID" value="SAMN04489712_11761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="182" mass="19784" checksum="6CA115B57CA09BDA" modified="2017-01-18" version="1">MADNLFAIAERGPTLVHAHNAHLQRHKSTMRMGGLPLEWWSAGAIVSTRLGEEYAFLATALGTIRHQGVDTPPPDTVEGLLYVLPEDHYVVDSRRLVTTFGNARPAPRVSPYYGYSPLDPAHLADSDGIVFVKDVPQTVLDARELLRPVRAGHEQPSGAESDRPGRDGVRPAHSRGSVRGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIW6</accession>
    <name>A0A1H6DIW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84526">
        <property type="protein sequence ID" value="SEG84526"/>
        <property type="gene ID" value="SAMN04489712_11719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="292" mass="31080" checksum="8A4ADA82CFBC4867" modified="2017-01-18" version="1">MAPAITGFDYRRVPVADGVSLNVAVAGSGPAIVLLHGFPQTHLMWRHVAADLAADHTVICPDLRGYGASDKPAETGPAVYAKRTMAADVVTLARALGHERFALAGHDRGALVAFRAGLDHPAAITHLACLDVLPTLDMWEVMHGVTAAVGFHLYLMAQPPGLPEQMIAASADAFFGHFLDGWTGDPQAIPADVRAAYLDACRAAVPSIVADYRASAGIDVDHDRADRDAGNRLRMPVTVLQQDWGAALGYDAAALWRAWASDLRHATVTCGHFMAEEAPADIAKALRDLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJI2</accession>
    <name>A0A1H6DJI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84806">
        <property type="protein sequence ID" value="SEG84806"/>
        <property type="gene ID" value="SAMN04489712_11771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG84806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="21448" checksum="5B29CBDEF9DA4A6A" modified="2017-01-18" version="1">MAFCGAALLISMAPGPSTVVIMRQSMLSGRRAGAAAMLGNEAGVLAWGVAAALGLSALLVASQVAYEVLRLAGAGVLVWFGARALWQARRRGGDGGGAVVEDAGDAGRGSLGRSFRLGLVTAAANPKAGVFAVSFLPQFVPEGAPVLGMLLVLSLLWVAIDVLWYLCVVWLVGSARRLMGRPAVRRRLEQVSGVVLVGLGVRLAAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL88</accession>
    <name>A0A1H6DL88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl-CoA_dh_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86197">
        <property type="protein sequence ID" value="SEG86197"/>
        <property type="gene ID" value="SAMN04489712_11915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="2">
        <location>
            <begin position="206"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="341" mass="35667" checksum="E0F77D325388EC71" modified="2017-01-18" version="1">MKLASTEQTDFAETVSALLRKRDPLERMRHAPGPRRFDAGLWSELVANGLLDPAEVGDVVTACLVAEALGRAAAPLPFLSASVAGALIVSAGGEVTGLATYGLLAEDGTWSAPALKIRDGLVHGALPFVPDADIADVVVAAVQAPEGRRLALVRRSDTTVEPLENLDATQPLARVVCGGSPATLLPAGGDALASAIEEARLLALALHSATLLGLATWLLDTTVEYTGQRVQFGMPIAGRQAVKHRCANMLIQVESIRSMVLELADALEAGTDDRALVAATTMAWTTEAAEEVAGGAFQLHGGIGFTWEHDLHHYFKRCTVGALLLGTSSHHRAQIAAALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLN3</accession>
    <name>A0A1H6DLN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_118137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86041">
        <property type="protein sequence ID" value="SEG86041"/>
        <property type="gene ID" value="SAMN04489712_118137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="33"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="4">
        <location>
            <begin position="470"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG86041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="692" mass="74785" checksum="7C13C3D672637912" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMZ3</accession>
    <name>A0A1H6DMZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase DDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86594">
        <property type="protein sequence ID" value="SEG86594"/>
        <property type="gene ID" value="SAMN04489712_119121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="107" mass="12123" checksum="EAED2F07D9A09C84" modified="2017-01-18" version="1">MDRGKPGSTLHVVSDRHGLPLVIGLSAGNVHDSHGLKPMAIVLHMRQRSWEGHAGQAVKLHADQAYDIPELRRWLARQRIEPRIARKGIEPDDRLGRYRWVIGRTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNG5</accession>
    <name>A0A1H6DNG5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86236">
        <property type="protein sequence ID" value="SEG86236"/>
        <property type="gene ID" value="SAMN04489712_11930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="156"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG86236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="30428" checksum="8FB71066E5C5EF83" modified="2017-01-18" version="1">MLDRTSVGARSAPYTRAWTSDDALLYALALGAGSDQLDLVTENSEGVTQRMLPTYAALLAGGTKPLRDRLGSWPAHATVHGAQRVTLPGPLPVDGEVEVVSTVARITDKGSGALLEIEATGTDHATGAAVFSALTSLFLRGQGWGEPERSTETDPVPDREPDLVVETPTNPNQALLYRLCGDRNPLHSDPTFAKRAGFEQPILHGLCTWGITARVLLQELGAAGQADPLGRVASYSGRFRTPVIPGDRLTVRAWQTGQGTWAHTTSVGERTVVDRGELVLHPQVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNU4</accession>
    <name>A0A1H6DNU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86841">
        <property type="protein sequence ID" value="SEG86841"/>
        <property type="gene ID" value="SAMN04489712_12016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="533"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="904"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="914"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG86841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1035" mass="112264" checksum="FF039BB0F3B6E403" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNW5</accession>
    <name>A0A1H6DNW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86871">
        <property type="protein sequence ID" value="SEG86871"/>
        <property type="gene ID" value="SAMN04489712_12023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="509" mass="57908" checksum="2A8C84AD205A64EF" modified="2017-01-18" version="1">MRSSPPSRGDLTPELLQTSQWTDELLHGAGIPVHDIPFVTVGGGIGSFVTLDYLRVYGVPTGSLRVLSNIDTPWETYEYLTRVSQIPRPERIRSDSSSRPDNLWGFPSYALEEAWRDKSLRHLRQVATEPIFDDYWTPRAGTVFQNLEREAKRISYWDMLVKGQVRMVRRRVGGGYFTVLTPPEGLSATRRVAFRSRYVHLAIGYPGLRFLPDLQDFRERYQDYHHVVNAYERHEHVYETLKTRPGVVVVRGGGIVASRVLQRLMDDREKYGLQTQILHIFRTFVTGSHGPGVFMRRRGGDGWAYQGFNYPKSVWGGQLKAQMRKLDGEDRAKLYKNMGGTNTPRRRRWQQQMAKGRRENWYHAFQGVVDKVEPSPDNRLVSHVRSDDGQLRQYASDFIIDCTGLEADITEHRVLADLLQHSGAGRNPLGRLEVERHFEVKGTASGDGALYASGAATLGGYFPGVDTFLGLQIAAQEIADDLARRGFCKKLGPLRSTSQWLKWARNKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQU1</accession>
    <name>A0A1H6DQU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86955">
        <property type="protein sequence ID" value="SEG86955"/>
        <property type="gene ID" value="SAMN04489712_12040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG86955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="169" mass="18846" checksum="2305C89C0F8CACAA" modified="2017-01-18" version="1">MARFPVVLRGYDCAQVDALTARIEDALQRGAGFLTAEDVLRSRFAVVLRGYDQQAVDEYLYECIRRLREGARPVRPQRRPRVPAGRLIDWIHGIEFSGAGMRTGYDARDVDAFLDRVVAGLRGAGPPVTAGDVRASSFRTVRFGPGYDEREVDRFLTELADALESAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DR89</accession>
    <name>A0A1H6DR89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87852">
        <property type="protein sequence ID" value="SEG87852"/>
        <property type="gene ID" value="SAMN04489712_12118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="17683" checksum="B0E02CDFF50DC2CE" modified="2017-01-18" version="1">MMSEEEAWHAEANRVFTALLAETEGQPPDPHGAGTLEREAADWLVSLALHCDDREYVEAWCLHLGRGLPSGHPVLGLSALCIGHLSRRFGHLSGEARALVEELAARCRRDPTDVDGNALSGLEDVEWYAPRRPRLVKLARWHRRTWNRVRWVFSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSN5</accession>
    <name>A0A1H6DSN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation-transporting ATPase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_12167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88064">
        <property type="protein sequence ID" value="SEG88064"/>
        <property type="gene ID" value="SAMN04489712_12167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="716"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="10">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG88064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="896" mass="94200" checksum="123058264E43F136" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTA3</accession>
    <name>A0A1H6DTA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88469">
        <property type="protein sequence ID" value="SEG88469"/>
        <property type="gene ID" value="SAMN04489712_1229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296208" evidence="1">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="160" mass="16904" checksum="76E796A79C9EED43" modified="2017-01-18" version="1">MRPAGLLVGITAASTIAFTATPAHAYAQQADFTIRPSPSSSDFCTWSGASTSAAPPSPLTIGLTAASPFCYSGVLAATSDPAFTFNENWPGTALSPQVAIAIFYGSLVGTCHYGAINLTLHRQGVTREYSSYSIFFTELAPKRTLCPDTMPIHLVSIVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTP1</accession>
    <name>A0A1H6DTP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88651">
        <property type="protein sequence ID" value="SEG88651"/>
        <property type="gene ID" value="SAMN04489712_12252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
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    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00441">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
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            <end position="218"/>
        </location>
    </feature>
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        <location>
            <begin position="230"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG88651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="380" mass="41834" checksum="C3979F982088DA4A" modified="2017-01-18" version="1">MEREVFDADHRQFREAVREFIAREITPHHERWEKAGICDRSVYTEAAKQGVIGFNVPEEFGGGGVHDFRFNAVVAEELAAARAHGPGFNLHNNIVAPYLLNLANDEQKARWLPGFASGEEVWAIAMTEPGTGSDLKGIATTAVRDGDEWVVNGAKTFISNGIHSDRVIVVARTDPGGGSRAFSLLVVERDMPGFTRGRNLDKLGLHAQDTAELFFENVRVPVANLLGKEGHGFYHLMANLPEERMSIAVSAVAASRSILDETVEYTKTRTAFGQPIGSFQNSRFTLAELDTEVDIAQVYIDRCLVALVAGKLSHVEAAKAKWWTTELQQKVVDRCLQLHGGYGFMMEYPVAKAYADARIQTIFGGTTEIMKEIVGRALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVP3</accession>
    <name>A0A1H6DVP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88655">
        <property type="protein sequence ID" value="SEG88655"/>
        <property type="gene ID" value="SAMN04489712_12253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="30"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="425"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="510" mass="54503" checksum="03847A8A2B7D4D25" modified="2017-01-18" version="1">MSTSTTETSTTGEPGPSLPELLLRLHDTGADVPAVDYQGSEVTWGELRELGEAAERELDVLGLGEGARVGVVLGNRPESVGLAYLTLSTGRCLTVFNPLQPAERLTADVLRTRPPVLFAPADLWEFAGFAEAAARAGLIGFAAEGRSVRRIDLPAVDGASSPVRAAPGVAVELSTSGTTGPPKRIPLAYRQIEAALGSVDGHMTPGKHERAPFTGGVVLITTPMVHIGGMWGVIQALVEARRMVVLPRFTVDAWREVIRAHRPRLAGLPPAAMRGVLNADVPAEDLASLRAVIAGTAPTPPELIEEFQRRYDVAVLVMYGATEFSGAVAGWSLPLHRQWWERKKGSVGRPFPGVGLRITDEDGNELPVGDSGVLEIRTAQAGDGTWTRTSDLAHIDADGFLWIEGRADDVIIRGGFKVHPPVVAAALERHPAVAEAAVAALPDERLGQVPVAAFEVRPGAEIPDAGELRAWCRRELLPYEVPVRFLHVTELPRGVSQKVSRVDLLALFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVY9</accession>
    <name>A0A1H6DVY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine-cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88765">
        <property type="protein sequence ID" value="SEG88765"/>
        <property type="gene ID" value="SAMN04489712_12275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="536" mass="58778" checksum="623504782CF05A02" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWL6</accession>
    <name>A0A1H6DWL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89740">
        <property type="protein sequence ID" value="SEG89740"/>
        <property type="gene ID" value="SAMN04489712_12447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="85" mass="8839" checksum="C5C35F272E5EB2EF" modified="2017-01-18" version="1">MDPSAAPLVITVTGRPTTVFVKVPGSDGAVLLRGELGPGETRKYDQAPLDVVVSDSASVEVRIYGELQTDTDGGRGQWAVPARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXQ8</accession>
    <name>A0A1H6DXQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">[lysine-biosynthesis-protein LysW]---L-2-aminoadipate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90068">
        <property type="protein sequence ID" value="SEG90068"/>
        <property type="gene ID" value="SAMN04489712_12529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="98"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="30151" checksum="EDA18BA79F5C96D1" modified="2017-01-18" version="1">MSGPLTDGPVVVLASRVRAEEKRILAALRRRGVDCAHADTRTLAGAPTGSAADRPLVLNREIGHARAVYAGTLLEAGGAVVVNSAAATEVCGDKWRTALALGQAGLPTPRTHLALTPEAALTALDELGYPAVVKPLVGSWGRLVTRVADRAMAAAVLEHVAALPSPRAHIVLAQELVAGGRSIRVVVVGGEALGATWHRTEGWRANVARGASAQALALRPDQAKLAVRAADATGAEIAGVDLIEDADGRPRVLEVNHGVEFTGFQDATGIDVAGHIADHLVTRKACLEAGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZT3</accession>
    <name>A0A1H6DZT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA carboxylase epsilon subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90363">
        <property type="protein sequence ID" value="SEG90363"/>
        <property type="gene ID" value="SAMN04489712_12614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="10002" checksum="2FCC4F3476588254" modified="2017-01-18" version="1">MDAEPDGPENSERAIRAMSEHTDVPLLRVEKGTLDPLELAAVTVVLLHRLNAARREPEPGSWPSAVSAPWRRPERIPAYRGPRSWQAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZX7</accession>
    <name>A0A1H6DZX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor WhiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90225">
        <property type="protein sequence ID" value="SEG90225"/>
        <property type="gene ID" value="SAMN04489712_12574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="99" mass="10590" checksum="D7DB215A050F2A05" modified="2017-01-18" version="1">MNVHPSLLPTLALHAALIVGAECQYDPELHTGPDAFADESAEDRAAREDVAAQVCASCPVRLTCFEYALRIEPEHGIWAGFTAAEITELADVRALGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0I5</accession>
    <name>A0A1H6E0I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90663">
        <property type="protein sequence ID" value="SEG90663"/>
        <property type="gene ID" value="SAMN04489712_1272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296369" evidence="2">
        <location>
            <begin position="30"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="240" mass="25572" checksum="569D2A889AF36AFC" modified="2017-01-18" version="1">MVRRRTRLAGLAAVLMAGCALLPSSTARPGGPVSVDEETAQQLTAAARTMLERRTEALVQQSRTRSLPAEVLGVRISPRLVREQQEALRRLETRNRAPVAGGPPFTAARTRLTVAAAVRDGDRIILDATEYTEMEYATPAGERAMTQQVRRRFEFSAEGGRFVLVDEHVVDPDASPINDPDGPPPAPPAPPEPSSPPQTPPSPSPETSPPAPSPAVSPSVHVDPAVPEPGQAGRVTNLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1I0</accession>
    <name>A0A1H6E1I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91024">
        <property type="protein sequence ID" value="SEG91024"/>
        <property type="gene ID" value="SAMN04489712_12817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="50" mass="5629" checksum="7B550EF76A867D27" modified="2017-01-18" version="1">MVSAAGGWRLLESAQPDDLRMQIRGALGFWPVSASQRHSSMSQRIYAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E266</accession>
    <name>A0A1H6E266_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91710">
        <property type="protein sequence ID" value="SEG91710"/>
        <property type="gene ID" value="SAMN04489712_13028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="9315" checksum="2157838642DD0754" modified="2017-01-18" version="1">MINADGTVVRSTGVTKVSKISTGAYYIELDPDINAAKAVPVISKLWTGAGTDAYVGTSSTPCGDPARNVLVFTTKAAGGFFDVPFNITVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E271</accession>
    <name>A0A1H6E271_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91778">
        <property type="protein sequence ID" value="SEG91778"/>
        <property type="gene ID" value="SAMN04489712_13048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="41"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="211" mass="24019" checksum="A2D6DDD0C39A5E62" modified="2017-01-18" version="1" fragment="single">NRKRVERLMRRAGLQGVYRRRGRRDLVNAATEEDLVQRHFDVAGPDRLWLTDITEHPTTEGKLYCAAVLDASCGRIIGWSIDTRQDTDLVINALAMAVTRRNPPPRSTILHSDHGTQYTSWAFGKRLRDAGLLGSMGTVGDCYDNSMMESFWGTMQLELLDTRTWKAREEPAGAVFEWIECWYNSHRRHSSIGMRSPVAFEGLNLPSDAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2K9</accession>
    <name>A0A1H6E2K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monosaccharide ABC transporter ATP-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91539">
        <property type="protein sequence ID" value="SEG91539"/>
        <property type="gene ID" value="SAMN04489712_12953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="29"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="268"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG91539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="522" mass="55360" checksum="46CF1642DEA29540" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3N8</accession>
    <name>A0A1H6E3N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_13120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91899">
        <property type="protein sequence ID" value="SEG91899"/>
        <property type="gene ID" value="SAMN04489712_13120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="58"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="147"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="254"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG91899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="424" mass="45953" checksum="0AFF6D7D1D7C2AF4" modified="2017-01-18" version="1">MKATTTTTSTEGPTLDEIAAEAHAFLAPRVPRRAPARLGEGPDDVMGVGLRRGDAELAEVETARAWQRDLFGAGLAWIDGPVEYGGRGLTEAHRNRVHAVLREYDVPNTACFMVGHDIVGPAILAHGTEEQRAAYLPGIWRGDIICCQLFSEPGAGSDLASLRTSARRADDGWVVNGQKVWSSYAHLAQLGELLARTGDPADRHRGITAFLVDMGAPGIDVRPLRQITGAEHFNEVFLDDVVVPDTQRIGEVDGGWPIALTTLTSERSLMGDEHNGLMNDPVRRLYALAESTGADTDPVVQELLAESWEREQIVRETARRSLDAPAEDQTGSVLKLMSTADMEFYIAVATRILGPRLAVDHGTWGTFAWSQLLLGAPAHRIAGGSDEIQKNIIAERVLGLPRDPRPPIPDRPTTTTTLRPQGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5M8</accession>
    <name>A0A1H6E5M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-coenzyme A thioesterase PaaI, contains HGG motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92992">
        <property type="protein sequence ID" value="SEG92992"/>
        <property type="gene ID" value="SAMN04489712_13639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="28433" checksum="D5E70D3C4EA66D85" modified="2017-01-18" version="1">MTAAHRGSGDLTTSTDPQASQGMLGELGFATRRVGEDLHGTASVTPAMHAPGTPHLRTSILAAWADTLTGLLATQVTAPRVPVTLELDVQLYRPAPANGTVDGIARVVKVGRSVFVAGVEFTSAGAEPLAIAHASFMMAPDPGITLPTAFDVELPLQRERLVKPFAERAGCTRRGPGVAVLPRSEDGLNASGTINGGLIALVAEEAALSLAPGDTLCSLGLRYLQPARVGPVVATARLRDGLGQVELRDAGNGDRLTGIATARTFHGARRTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5Z1</accession>
    <name>A0A1H6E5Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93130">
        <property type="protein sequence ID" value="SEG93130"/>
        <property type="gene ID" value="SAMN04489712_13721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="11140" checksum="52E2712AABFD3EDE" modified="2017-01-18" version="1">MWDGLVLVAFGLCGLIAMRAAVSNLRSSGSGRPDRKSMEEYFDRFGLFLVGSVFVVVAIAALFFGFSVRVAPWQHFASVGLVALGVVTVKFVWKRALGRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6V0</accession>
    <name>A0A1H6E6V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92899">
        <property type="protein sequence ID" value="SEG92899"/>
        <property type="gene ID" value="SAMN04489712_1365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="174"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="324" mass="33776" checksum="D849DDA9AD7A78E5" modified="2017-01-18" version="1">MMDAETAELLAESLGRAFRHESVAAVEASLAEVGWREALQEEGAAVIPLLFTRQGAANATSGALDDLLTAALGLPADPGTAFVLPEFGTYGTPGRVQDGGLTVRGLGTARMPSAARAVLLAERDGALQAITVETGGLCTRPVGGVDPRLGLVAVEGQGVLASGSTAVTPAAWENALASGRVAVAYELIGASRAMLRLAREHAVTRIQFGRPIGTFQAVRHRLAECLVAIESAEAAAAIALGTGDRVSPLLAGMAKSLAGRNARTVARHCQQVLAGVGFTDEHDFHHYFRRVLTLDGLLGDARTLTRELGEELLRDRRLPAAPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E757</accession>
    <name>A0A1H6E757_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92725">
        <property type="protein sequence ID" value="SEG92725"/>
        <property type="gene ID" value="SAMN04489712_13512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="30902" checksum="17762390C96FD67C" modified="2017-01-18" version="1">MASAAERFANGTALVTGGGAGIGEGFVRHLAALGMRVVVADLDRSRAEAVANDVRNSGGRAEPYEVDVTNEAAVERMAADVYAEFGSVEMLVNNAGIETGGRLWDIPVSRWRQVMAINVDGVFHCVRSFVPRMIAAGRPAVVANLSSVGGVRTVPLQTPYIVSKHAVLALTECLHQEIRLTGAPIQVCAVLPHSVRSRIFLDAQAAAPAGDPAADRFFGWMQEANVTSGLDPVDAAEHMVGQIAAGRFWIFSDDERGAEALQARADHLAHQTEPPDPRAMFQVLADDHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9N5</accession>
    <name>A0A1H6E9N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_14817</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M29 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94538">
        <property type="protein sequence ID" value="SEG94538"/>
        <property type="gene ID" value="SAMN04489712_14817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00919">
        <property type="entry name" value="THERMOPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG94538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="410" mass="45200" checksum="035ABBA0BADA7874" modified="2017-01-18" version="1">MSRPDSPDIPAADLTAYSELILDVSAPVTEDDLVAINAEIEHAPLARALAEGAYARGARYVDIWYFDPYAKRSRVRHADPATLHEVPAWLDRRNHELGQRYGVLINIRGEAEPDLLGDVDPVRAGLDRMPNLSSRYHLQSNDLVCWSIVAYPTRSWSRHVFGQEDVARLWDHLKHFLRLDRPDPSAAWHTRLDELRGRADRLNELNLDAVHFKGPGTDLTIGLIPQAEWTVVGFKAADGRYFVPNLPSEEVFTTPDHRRIDGTVSATRPLSLAGTVVRDLRLTFTGGRVSEVHASSGADVVRGHQATDPGAARLGEVALVDGSSPIGRSGVTFMETLLDENATCHLAWGSGIPQAIPGASRLGRDRIEEMGVNFSAVHTDFMVGGPEVTVTGIDGDGRRIVILREDEWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAZ7</accession>
    <name>A0A1H6EAZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_14715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000047">
        <property type="protein sequence ID" value="SEG94421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94421">
        <property type="protein sequence ID" value="SEG94421"/>
        <property type="gene ID" value="SAMN04489712_14715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009029639" description="Carboxylic ester hydrolase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="99"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG94421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="594" mass="63035" checksum="ECF35360CE4F12B1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECD0</accession>
    <name>A0A1H6ECD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase YjhB, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000055">
        <property type="protein sequence ID" value="SEG94921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94921">
        <property type="protein sequence ID" value="SEG94921"/>
        <property type="gene ID" value="SAMN04489712_1552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="17425" checksum="2C27A0FCFDE72C3F" modified="2017-01-18" version="1">MARTEYYDDPDAPKPNSLVVAASAVVANERGEILMQRRADSGLWALPGGAMEMADSLPGTAVREVKEETGYDIEVIGLVGTYTDPRHIIAYSDGEVRRQFNVCFLARLVGGELQISDESLEVRWVPPGELDELPMHHTQRLRLKHYQENRTAPYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EDA8</accession>
    <name>A0A1H6EDA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000056">
        <property type="protein sequence ID" value="SEG94946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94946">
        <property type="protein sequence ID" value="SEG94946"/>
        <property type="gene ID" value="SAMN04489712_1561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="115" mass="11548" checksum="1AD97F16DAF11EF9" modified="2017-01-18" version="1">MPGGADKWRISPAIPTIANCALAALWAFSALGGWGETAFCGEGGRHDPSCAGGFTTAVLASLVAAVPAALIAVMAWTLPAVRRNTVRLEAALATAALLWVAAEGVLFVGGSLAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S129</accession>
    <name>A0A1H5S129_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43618">
        <property type="protein sequence ID" value="SEF43618"/>
        <property type="gene ID" value="SAMN04489712_10114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF43618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="58" mass="6768" checksum="376F2D37438B04B3" modified="2017-01-18" version="1">MKNSDDDWWFCLRHMRVEHGAGCANKDRMGPYRTESEAAGALELARRRNEAWNAQDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S243</accession>
    <name>A0A1H5S243_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized membrane protein YckC, RDD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44682">
        <property type="protein sequence ID" value="SEF44682"/>
        <property type="gene ID" value="SAMN04489712_10150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016795">
        <property type="entry name" value="UCP021697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021697">
        <property type="entry name" value="UCP021697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="45"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF44682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="160" mass="17091" checksum="AA4601FEAFA73F6C" modified="2017-01-18" version="1">MSSGRQTAGGPRWTQTWLGGARSAGADLGYPGQRLGLPEHGSQAVAGYGRRLVALFVDWGLCMLISAFLARAFELSPPGRSLLTLGLFGLQAVVLTATIGMTLGKRLCGIRVVRLDGRPVGPVWALVRTLLILTVVPALLWDRDHRGLHDRAANTAVINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SGM9</accession>
    <name>A0A1H5SGM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XdhC Rossmann domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49782">
        <property type="protein sequence ID" value="SEF49782"/>
        <property type="gene ID" value="SAMN04489712_101203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_C" evidence="1">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="18386" checksum="2040848BB28AE920" modified="2017-01-18" version="1">MSHVHEDDPACAVAHGEVRPDTSDRTLVAVFASPVAEFLLRYGADLGFRTLLLEPDPARAAGWDGPKVITGPTADLDGRADVVVTDHHRDELGPVLRDLLAVPSRWIGVMGNPRHPAPHVPALRALGVADDDIARVHRPIGLNIGSRTPAEIAVATLAGLLADRNGRPGGFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SP84</accession>
    <name>A0A1H5SP84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52244">
        <property type="protein sequence ID" value="SEF52244"/>
        <property type="gene ID" value="SAMN04489712_101298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF52244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="242" mass="25676" checksum="36100DA43657728D" modified="2017-01-18" version="1">MSGPTTTQAGFSPAFQRLGAALAAVVLQQQETLAEFLPREDWNADLTARTYSSGGVTVRVSLLGSYAVREQTWLWGWANPQFGEGHPAVAPTLVVREIGERLGVPELVTPEVDLSWYDGPAGHGGELVAMVAGGILGGGGYIGAGYDGGSAYLHVDDPQTPRAGWDPIPVPRLVLNAAGLFPHDPRLTLARFLSHHRVPYRETSASIEARTPGGGSARARFDSRGRLTDWQSSAGGEAFTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SZB9</accession>
    <name>A0A1H5SZB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55855">
        <property type="protein sequence ID" value="SEF55855"/>
        <property type="gene ID" value="SAMN04489712_101421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF55855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="501" mass="54577" checksum="EFBFBE661922953B" modified="2017-01-18" version="1">MDDSGAAEPAAVSETHIGIVFFAGDRAYKVKKPVDVGFVDLTARKARERMCRREVQLNRRFSPDVYLGVAEFGGLSGEPPEPVVVMRRMPADLRLATLVRARRPVDDALRAVARRLAAWHSVAPRGAEISVQGSRNALRRRWRDSFDQVRPFHDQALKGAEATEIEERTLRFLAGREPLFDARIRAGRVVDGHGDLMATDIFCLPDGPRILDCLEFDDRLRWLDGLDDAAFLAMDLERLGAPALAERFLSWYAEYAGDPAPASLRHHYVAYRAFVRAKVACIRYGQGEPHAAAQAGLLAEVALRHLRAGAVDLILVGGLPGTGKSSLARLLGDRLGCTVLNSDVVRKELADISPEEPAAASYGTGIYSPAHTERTYATLLARAETLLEQGETVVLDASWTVAEHRTLARLLAERAHADLFTLRCEAPPALTAQRLRARTGGPSDADPAIAAVMASHAAPWPEATVIDTSGPVGESAGQALSVVRPHGAEHLWHRRPQIAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T4W4</accession>
    <name>A0A1H5T4W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57198">
        <property type="protein sequence ID" value="SEF57198"/>
        <property type="gene ID" value="SAMN04489712_101463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="133"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="239"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF57198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="426" mass="46685" checksum="5CFB52BA35B5EA55" modified="2017-01-18" version="1">MSTPLAECRTEDEAVQAVREWLAVALPANWREAGERGGPSAVRAARTPDEYRAWYPAFARSGLVVPQWPVEYGGLGWPRALARAAERVLAPYHLPRLNPLGLNLAAPALFEHGTAEQRLRFLPRIVSNEEVWCQLFSEPGAGSDLASLATRAERDGDLWRITGQKVWTTWAHLADFGVLLARTDPDVPKRRGITYFLIDMHQPGVEVRPLRHLGGEVDFNEVFLDGAVVPDAQRVGEVGDGWRVARATLSGERQMVSGSGSGGVDRIGGSGTRRLVRLARERSAQGLPYGWDDARTRHELVRLWCEEQIRAWTNARVRAGLKAGLPPGPESSIGKVHGSELNQRIQALAARMLGPSATAWAGDPGDPGDYAGSMPAEVRGMLRSRANTIEGGTSEVNKNILAERVLGLPKEPDPWEGRPWREVPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TBB8</accession>
    <name>A0A1H5TBB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60172">
        <property type="protein sequence ID" value="SEF60172"/>
        <property type="gene ID" value="SAMN04489712_101556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF60172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="32319" checksum="CEA13299D0F2F67A" modified="2017-01-18" version="1">MTTMAKTAGRTRAPRSRSRAAETARRAWSDASGRIAMVLLAVLVLAALLAPLLAPSDPAAQNLAAASRPPSWLGGEGGHLLGTDTLGRDVFSRLLYGLRLSMVVGVVTATASALFGLLLGLLAGYYESTAGMVLMRLADVQFAVPFVAVGVALAAVVGPGVVKLMIILAVWGWVNYARTIANSVSQVKRMEFVTAARTIGARTPAILLRHIAPSVLGPVIILWSTSAGVLVLVESALSMLGLGVQPPDFSLGSMLADSRTTLRLAWWATVFPGLAIMVVVVAFNLLGDALRDAFNPSVRTEHDPELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TEX0</accession>
    <name>A0A1H5TEX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase, N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61290">
        <property type="protein sequence ID" value="SEF61290"/>
        <property type="gene ID" value="SAMN04489712_101590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF61290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="44353" checksum="EED3DFE63B0C0CB1" modified="2017-01-18" version="1">MGFEVPASVRPIRDAVYAFMTERVEPAEPVLRRGDRDSAALLAELQRQAKQEGLWALGHPEELGGGGLPFLDYVYVNEVQGRSEFGQLALGTFTLQDSLMLHRHASAEQRERYLRPLVQAEIYPSFAMTEPGISSSDPTQLTTTATLEGDEWVIRGRKWFTTLADRAAYTTVMCRTEPEGTVPHLSFSMILVPTDTPGYTIVRDTPVLGLDGGHCEVLYDEVRVPAQNLLGPRGHGFVIAQERLGPGRIFHCMRWLGQAQRAFDLMCARLHERSAFGGPLADKQLMQQHVFDSYTEIQAARLLTLQAAHRIDAGDQARVEIGAIKVAGARMLHNVIDRAVQVHGAQGLTDDTPLGRMYRHAREARIYDGPDEVHITTTARRILKEYAQGRNWEFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TI94</accession>
    <name>A0A1H5TI94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62592">
        <property type="protein sequence ID" value="SEF62592"/>
        <property type="gene ID" value="SAMN04489712_101633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF62592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16953" checksum="615AFE2C52D0CD58" modified="2017-01-18" version="1">MDRRILALVQRDARLTAAQIGERVGLSASAAHRRLQRLWQGRVVEAQVAVVNPRAVGRPLVMIVGLEIERERPEDLHELKRWLAAEPAVQQAWYVTGDADFTLVITARDTEDYDGFMQRLVAENRNVRKFKTSVVLSTLKRGLAVPVDGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TU72</accession>
    <name>A0A1H5TU72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66310">
        <property type="protein sequence ID" value="SEF66310"/>
        <property type="gene ID" value="SAMN04489712_101746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF66310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="27370" checksum="E93ED5E0B42BAB00" modified="2017-01-18" version="1">MPFPFDLQGRKALVTGASRGIGRAISLALARAGAEVALLARGADELDKLAREIDDLGVRAVPIPTDVTVPAQVERAVDTALAEFGQLDVVVNNAGGTGRFGPFLSLPHSAWEQAMRLNFDSAVHVCRAVGPHLTGQRGGSVVNVASFAGQGGLPLLAPYAAAKAALISLTRSLAAEWAVSDVRVNAVVPGWVATDLTAPLSADPATSASLLEAVPAGRWGRPEDVAGAVVYLAGDASGLATGSCLTLDGGLSVLSGGPATLRFFKETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TUD4</accession>
    <name>A0A1H5TUD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase, activator-dependent family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66370">
        <property type="protein sequence ID" value="SEF66370"/>
        <property type="gene ID" value="SAMN04489712_101748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="DUF1205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030953">
        <property type="entry name" value="Glycosyl_450act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="DUF1205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04516">
        <property type="entry name" value="glycosyl_450act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1205" evidence="4">
        <location>
            <begin position="228"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF66370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="445" mass="48994" checksum="63F1F3BD5F9B5F20" modified="2017-01-18" version="1">MVGRDRAGAPTAKGDAVRILITTLPFKAHAYPRVPLAWALRAAGHEVRVAASPDVVDDIADAGLTAVPIGEAFDAEALMAEIREREATGDVPDPEPLMKIDERRPERLTYDFMHGLFTVLTTVVFKNHAPVPATDDLVAFAREWRPDLVIWDPLGFGGAIAARACGAAHARLMYGLDVIGWMRERYLDAVRERPAPLREDPMEEWLTPWLERYGCAFGEDVVMGQWTIDPGPSWMRLPVDHLCVPMRHVSYNGRATVPGWLRAPPARRRVCLTLGLSHREVLGGNRVSMSDLLEAMADLDAEVVATLTADQLSGVRRVPDNVRVVDFVPLNELLPSCSAIVHQGGTGTMQTALAHGIPQVLLPGDLWDTMLKAERLEESGAGLCVWDIERFEARELRDMVGRILDDPFFTRAAAGLRTRMAGTPAPADVVPSLERLTAEHRARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U0X8</accession>
    <name>A0A1H5U0X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, FadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67911">
        <property type="protein sequence ID" value="SEF67911"/>
        <property type="gene ID" value="SAMN04489712_101797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF67911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="30371" checksum="236372519FF88DE9" modified="2017-01-18" version="1">MTDTTDASGRSGGIPIVYRPGIAQHAADSGNGQAASRSPKASEVTAAAIVHHIVEAGLRVGDRLPSEADMLAHYNVSRETLREALRLLEVQGLISIKRGPGGGPLVEPLNAKYLARTATLYFRLSGATYDELFDTWETIEPPLAARVARLRDRRLKARAFAPFLDYRPEEHERDEVFRDLNNFHAVIAALSGNRVLTLLTQAVTHIATDHVVEKIDPIEESDHMLHSHRDIAEAIIAGHSKRAATLMQQHIAAVTHSYRERWPERMSKPIEWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UXJ5</accession>
    <name>A0A1H5UXJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79694">
        <property type="protein sequence ID" value="SEF79694"/>
        <property type="gene ID" value="SAMN04489712_10275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF79694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="178" mass="18472" checksum="12176F23163E2D2A" modified="2017-01-18" version="1">MTPIEERLREVLDEHSVDRPVPSGLAERAERRGRRIRRRRRAGGAALAAASVTAAVAVGTAWVAPQPAEHAGQVASAPSTAPPAPAVTVSRGGQAPPDGRLCAKAAIRTENGRVARLVLSNCSQQEAARLKAKIIQQCPQAKDGLHTSEAGDVQVTGADLVNCALKALGVAKPPAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VA08</accession>
    <name>A0A1H5VA08_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0182 protein SAMN04489712_102234</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0182 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84169">
        <property type="protein sequence ID" value="SEF84169"/>
        <property type="gene ID" value="SAMN04489712_102234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="872"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="911"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="935"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="958"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF84169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="974" mass="106634" checksum="103922CB0694B828" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VD61</accession>
    <name>A0A1H5VD61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferric iron reductase FhuF-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84731">
        <property type="protein sequence ID" value="SEF84731"/>
        <property type="gene ID" value="SAMN04489712_102254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="3">
        <location>
            <begin position="204"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="432"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF84731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="600" mass="64656" checksum="D48FF36EA16B3E73" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VGS8</accession>
    <name>A0A1H5VGS8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86522">
        <property type="protein sequence ID" value="SEF86522"/>
        <property type="gene ID" value="SAMN04489712_102319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF86522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="85" mass="9308" checksum="1FD3615C905A709C" modified="2017-01-18" version="1">MSEQEGPDGVIIEFIDAADVPDEHRKDNKIFAPGTQAITMRSAAEPDGPTLYFTEAEWEAFVAGVKDGEFDDLLEDLPPQDDPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VPZ0</accession>
    <name>A0A1H5VPZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid/cholesterol/gamma-HCH transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88587">
        <property type="protein sequence ID" value="SEF88587"/>
        <property type="gene ID" value="SAMN04489712_102384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF88587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28301" checksum="4C8ACA9BDEA5EF75" modified="2017-01-18" version="1">MALSLQKAPGHALRRAGRAADETGLLFVTLLEGLRRTWDIRTWWGEFIEQCWFIARVTSVPVLLIAIPLGATISLQAGDIARQLGAQSGTGALVVANMITQVAPLASALLISGAGGSAITSDMGARHIRDELAAMEVMGINPVHRLVTPRLWAASTVALLLCSVVILSGTAGGFYFNVIQQGVSPGAYFDGATSLLQISDLMITLFKAWVFGFIAAAVACYAGMNCDYGPVGVGRAVNKAVVMTSILVFSANYVITMLYQVLVPPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VQ67</accession>
    <name>A0A1H5VQ67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89088">
        <property type="protein sequence ID" value="SEF89088"/>
        <property type="gene ID" value="SAMN04489712_102400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005268">
        <property type="entry name" value="CHP00725"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00725">
        <property type="entry name" value="TIGR00725"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF89088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="175" mass="17568" checksum="EDB77185C54A0188" modified="2017-01-18" version="1">MDRVTVQVAVCGPADCSPQEERWAREVGRLLAGRGAVVVCGGQGGVMAAVAAGARAAGGTVVGLLPAADRAGACPDLTVVIPTGLGQARNVLIVNSADAVIVVGGSWGTLSEVAHAMRRGGVPVVALGGWRVLDRDGREPPGVRHAATPAEAVRLAFPPDADSGTDDAFRDAADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VSQ3</accession>
    <name>A0A1H5VSQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proteasome lid subunit RPN8/RPN11, contains Jab1/MPN metalloenzyme (JAMM) motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90250">
        <property type="protein sequence ID" value="SEF90250"/>
        <property type="gene ID" value="SAMN04489712_102442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF90250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="134" mass="15322" checksum="DAA3279518A4D039" modified="2017-01-18" version="1">MLTIERALYDKIVAHARADHPDEACGIVAGPVGSDQPTRFIAMTNAERSPTFYRFDSMEQLRVWREMDDNDEEPVVIYHSHTATEAYPSRTDISYASEPNAHYVLVSTRDPEAEEFRSFRIVDGEVTEEEVRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VYY0</accession>
    <name>A0A1H5VYY0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SAMN04489712_102514</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92196">
        <property type="protein sequence ID" value="SEF92196"/>
        <property type="gene ID" value="SAMN04489712_102514"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="14">
        <location>
            <begin position="26"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="188"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)" evidence="13">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEF92196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="352" mass="36490" checksum="5E44DB44FC5EF123" modified="2017-01-18" version="1">MNRAWRGLITEYRDRLPVTDATPVVTLLEGGTPLLPASRISQLTGCEVYLKVEGANPTGSFKDRGMTMAISKAAEEGAKAVICASTGNTSASAAAYAVRAGMTCAVLVPQGKIAMGKLAQALVHGARLLQVDGNFDDCLELARKLAVDYPVALVNSVNKYRLQGQKTAAFEIVDALGDAPDVHCLPVGNAGNISAYWMGYSEYAADGVATRAPRMLGFQASGAAPFVRGEPVAKPQTIATAIRIGNPASWDLAVAARDRSGGAIESVTDRQILAAYRLLAREEGVFVEPASAASVAGVLQAREEGLLEAGQRVVCTVTGNGLKDPDWAISGAPAPTTVKVDAHAAASALGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W341</accession>
    <name>A0A1H5W341_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93895">
        <property type="protein sequence ID" value="SEF93895"/>
        <property type="gene ID" value="SAMN04489712_102571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="434"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF93895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="524" mass="56931" checksum="97D4DABA6D5AAFF5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XBR6</accession>
    <name>A0A1H5XBR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03083 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09169">
        <property type="protein sequence ID" value="SEG09169"/>
        <property type="gene ID" value="SAMN04489712_103182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG09169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="23727" checksum="5CC40A10ED4CF4B0" modified="2017-01-18" version="1">MTPTAEPTRDQVVRGLADEHATFAALVAPLSEEQWRAPTRCSGWQVCDVAAHVAANAVESVDGTIGGRSPDEQARALRGSTPKEIADLLSTASGRLRGFLERLDDDTWHAPSPVAARTIGNGILTLWYDTFVHHNDISAALGRPHDTTGPGLTASVYWLVQELSRLERGPLTLDLDGLPPRRVGTGGPTVTGDPMRFVLAASGRTDPTALGLDESVNVHLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XCI0</accession>
    <name>A0A1H5XCI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Virulence factor Mce family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08916">
        <property type="protein sequence ID" value="SEG08916"/>
        <property type="gene ID" value="SAMN04489712_103173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289278" evidence="1">
        <location>
            <begin position="22"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="112"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG08916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="347" mass="37416" checksum="7D3739001EFD581F" modified="2017-01-18" version="1">MRRLAATAFALALAASTGGCAVTEIGDDTYRITVYFAKTTSLYEQSRVKVMGADAGSITAIRGEGDRVRVDLTIDGSVPVHRDARAVIASANALGERYVQLEPAWRPGQPKAPPGMVIPKERTELPVEIDDALAAFARLNRSIDAQRLGTAVERGADGLRGHGDDLNEALRGTASLTHNLAAHDQRIVSLAEGLRTLAADLNRRDRRLGELIESFSTTSRSLAEERARLSEFVEGLAAVIRRSEVLITAYQETLPGAVTDLSNIVMTLKANAGALEQAITALGHFADVTVRAWDRKNHVATIRLVVHGTLRAWLQPLFTAMGWGTVPCLEGRPELATCTDPPGRTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XJI2</accession>
    <name>A0A1H5XJI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_103272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11560">
        <property type="protein sequence ID" value="SEG11560"/>
        <property type="gene ID" value="SAMN04489712_103272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG11560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="453" mass="48829" checksum="DABBAED56B1FA317" modified="2017-01-18" version="1">MANGGWCVARHEGRVVFVRHTLPGERVRARVTEVTKNFLRADAVEILRASPDRVVPPCPFAGPGRCGGCDWQHASLPAQRRLKAAVVEEQLSRLAGIDRTVVVEEVPDPHHDEDELTARGPGLGWRTRVQFAVRDDGVVGLRRHRSHQVEPVDECLIAHPGVEMIGIERKRWPGAASVEGIVSAGTGDRLVALRERASRSRGGGRRAAKVPRLDVPVRLLRGRGTPGGPQPYVREEAAGRLWQVTGSGFWQVHPGAAQALADAVLAALEPRPGEIALDLYCGVGLFAGVLAERVGRDGLVVGVESDAQAVRDARFNLRDLRNVSIEQGRVEDVIAELEFGREHRPAEAGRSGRGGPAGRGGAGRRGGARERENGLRADLVLLDPPRTGAGRQVVEHVAGLAGRKVAYVSCDAATLARDLAYFGEFGWTLQSLRAFDAFPMTHHVELVATLIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XW79</accession>
    <name>A0A1H5XW79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15903">
        <property type="protein sequence ID" value="SEG15903"/>
        <property type="gene ID" value="SAMN04489712_103435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG15903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="188" mass="20236" checksum="1D382F4FC8F90FCA" modified="2017-01-18" version="1">MAIASFMVPIGTPAPDFTLPAIDGGTVSLGDLSGSPALLVMFLSNHCPYVRRVESALGSVIAEYQDKGLAAVAVCSNDVVNYPDDGPKFLREQAERAGFTFPYLVDESQEVARAYRAACTPDFFLYDRERRLAYRGEFDGARPRNDVPSDGGSLRAAVDRVLAGEPVPEPHTPSLGCGIKWKPGNEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YLU4</accession>
    <name>A0A1H5YLU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Linoleoyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24612">
        <property type="protein sequence ID" value="SEG24612"/>
        <property type="gene ID" value="SAMN04489712_10465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG24612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="371" mass="41884" checksum="D6D2A8E5B6B5930F" modified="2017-01-18" version="1">MPTTVRLALIDVEEFGRELDRIRDEVIAGLGEDDAGYIRGVIAMQRRLELTGRALLFASWLPPAWAAGTAALAIAKILENMEIGHNVLHGQWDWMRDPKIHSTTWEWDNATPAAQWKHSHNFIHHTWTNVLGKDRDIGYSAMRISPEQKWHPIHLAQPLYNVLLALFFEYGIAIYDAELERIPTGDKSPKEALNQLRAVAGKARRQILKDYVAFPLLAGPCLLPVLLGNLTANMTRNMWAHTIIFCGHFPEGAEFFTEDQIENETRGEWYLRQLLGSCNIDGGRLLHLMSGNLSHQIEHHLFPDLPSNRYAEIAPRVRALCERFGLPYNSGSLARQAGSVWKRVLRLALPGPGRPRPEETAPPADELRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YSI0</accession>
    <name>A0A1H5YSI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">topA</name>
        <name evidence="11" type="ORF">SAMN04489712_104164</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27121">
        <property type="protein sequence ID" value="SEG27121"/>
        <property type="gene ID" value="SAMN04489712_104164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="195"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="822"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="891"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG27121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="930" mass="101421" checksum="619A06A209DA99F1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YWV6</accession>
    <name>A0A1H5YWV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lsr2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28498">
        <property type="protein sequence ID" value="SEG28498"/>
        <property type="gene ID" value="SAMN04489712_104225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG28498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="11649" checksum="32A3FF7EE005EC17" modified="2017-01-18" version="1">MAQKVQVLLVDDLDGGEADETVSFALDGASYEIDLSGDNAKKLRDSLQPFVEHARKAGAARRRRTRGASSRERSADIRAWAKARGIKVNERGRIPATVVEQYEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXQ6</accession>
    <name>A0A1H5YXQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">radA</name>
        <name evidence="8" type="ORF">SAMN04489712_104240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28834">
        <property type="protein sequence ID" value="SEG28834"/>
        <property type="gene ID" value="SAMN04489712_104240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="67"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="351"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG28834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="468" mass="48957" checksum="79261D98CAA84C3A" modified="2017-01-18" version="1">MAKAKTPKAAYRCSECGWQTSKWVGRCGECQAWGTVGEAGSAAPPRVVTAGPVTSPARPIGQVDVQSAQTRPTGLDELDRVLGGGMVPGAVLLLAGEPGIGKSTLLLEVAALAAARTPVLYVTGEESAEQVRLRADRVGAVADALYLAAETELSALLGHVDAVEPKLLVVDSIQTIGAAEVDGAPGGVTQIREVTANLIRVAKERGITTVLVGHVTKDGAIAGPRLLEHLVDVVLYFEGDRHSRLRMIRAVKNRYGPTDELGCFDLSEVGIVGLADPSGLFLTRREEPVPGTCVTVTLEGRRPLVAEVQALVAKSFLPAPRRATSGLESARVAMVLAVLARRCQISMHDQDVYVSTVGGVRLSETSVDLAVALAVAGSTVEQALSGNVIALGEVGLAGEVRAVPGVQRRLAEAGRLGFKAAVVPKGSLELGEDTPLRRAELRAISYEGMRVMEVDSLNQALQVAFTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z1U3</accession>
    <name>A0A1H5Z1U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30569">
        <property type="protein sequence ID" value="SEG30569"/>
        <property type="gene ID" value="SAMN04489712_104314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG30569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="22594" checksum="C9CDCDC1367E2577" modified="2017-01-18" version="1">MVSAVGTMPGLRERKKAATRQALHEAAMRLAVEHGLEQVTVEAIADLAGVSRRTFSNYFAGKEDALLYGDEERLRTLVDAFAVRPPDEPSWTALRHAFDDLYSRLGRSPDPEWAQRVRLVKKHPSLLGRQMANYATTEQRLAELIGQRDGTSPGSTRPRIMAAAFLHGIRIASTLWVEEQPPRPFEEIAHEVMDELARPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z4C6</accession>
    <name>A0A1H5Z4C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31191">
        <property type="protein sequence ID" value="SEG31191"/>
        <property type="gene ID" value="SAMN04489712_104344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG31191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="94" mass="10169" checksum="B051666182886156" modified="2017-01-18" version="1">MTEAKRHLEELGTALTEAGFKVRVVVGDPPVLHVAGVGTAELAEQIGCRVNPLDGQLWFQWVALEVFLGRASDVPDVVERIKYIVHSQTSGGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZHQ6</accession>
    <name>A0A1H5ZHQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_104560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35772">
        <property type="protein sequence ID" value="SEG35772"/>
        <property type="gene ID" value="SAMN04489712_104560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="9">
        <location>
            <begin position="44"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="10">
        <location>
            <begin position="236"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="11">
        <location>
            <begin position="332"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="8">
        <location>
            <begin position="492"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG35772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="574" mass="60219" checksum="CCCC8B7AECFE5A64" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZVU8</accession>
    <name>A0A1H5ZVU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40653">
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        <property type="gene ID" value="SAMN04489712_10544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG40653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="30183" checksum="0F7A814FC8AEBB75" modified="2017-01-18" version="1">MAGFAQQVVEGMGAGAIYAGLALALVLIHRFTGIVNFAQGELAMFSTYVAWQFMDAGLPFWAALAITLTVSFTGGMLIERVVIRPVEGAPELTMVIVTVGLFIFVNAAAGWIWSFLIKDFPNPFPDGALRAGGVAVGYPTLGILAVVGLVMGLLYLLFRHTGIGLGMRAVAADPDSARLVGIRVGRTLALGWGLAATVGAVSGVLVAPLLFLEPNMMGGVLIYAFAAATLGGFDSPAGAVVGGLVVGVAETLAGAYVDVVGSDLKIGVPLVIILVVLLLRPQGLFGRATVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZWN1</accession>
    <name>A0A1H5ZWN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG39876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG39876">
        <property type="protein sequence ID" value="SEG39876"/>
        <property type="gene ID" value="SAMN04489712_1054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292037" evidence="2">
        <location>
            <begin position="26"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="56"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG39876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="349" mass="36907" checksum="7C7DEE7E061E433C" modified="2017-01-18" version="1">MTSNVGRRRFLLTGSLVGAGVLATACTSNSEETGNTNQQSVSTGGDNDKPGTKVTIGFSAPAADHGWIAAIAKNAEAQAKQYSDVDFKPVEPTNDINQQISAVESLIAQKVGALVILPNDGQQLNQVARKAMDAGIPVVNLDRVFPDKLSYRTWVGGDNYGMGVAAGHYIGKKLKDKGVAKPVILEIQGIATLPLTQDRSKGFADALKTYGFEVTAQQDAQFTVESGNEVAGNLLQAHKKIDALWNHDDDQGVGVLAAIKQANRNEFFMVGGAGSANAMREIKNGGVLEATVTYSPSMASSAIKLARLIAQGKGMADLVEKQVPQSITLASETITKDNVDQYLPLGFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZL1</accession>
    <name>A0A1H5ZZL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41137">
        <property type="protein sequence ID" value="SEG41137"/>
        <property type="gene ID" value="SAMN04489712_10566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025329">
        <property type="entry name" value="DUF4235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14019">
        <property type="entry name" value="DUF4235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG41137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="9633" checksum="EEAEACF1162A3C21" modified="2017-01-18" version="1">MYRAFSVIFSMLGGMLAGMLFKRVWKLAAGEKDTPHAEDLERDLVEVMAAAALQGAIAGMIRGATKRAGARGRLRTAQRKAARELAGIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A0G4</accession>
    <name>A0A1H6A0G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42243">
        <property type="protein sequence ID" value="SEG42243"/>
        <property type="gene ID" value="SAMN04489712_105125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG42243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="22425" checksum="328394E59348DA65" modified="2017-01-18" version="1">MELRLGSRVFGAGDFAIWLSGGAERPPEHTDVPERADIPEGADVPEPVNVPEWADVPGPGDVPEGVDIVTATGGGPVAASLVVAQFAPVPGDAGGRAALLVGDELAETAAATGAGLVCRDPQRALTAGVRADGIVVDAGPRPPAQRVAELTKDGLAVMVSLDDEPVGEDTGLLAAVSIYAWLGVRVFRVAAPDVAPVRQVLDMVASIAGTRPPALTRRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJL3</accession>
    <name>A0A1H6AJL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48898">
        <property type="protein sequence ID" value="SEG48898"/>
        <property type="gene ID" value="SAMN04489712_105503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG48898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="240" mass="25822" checksum="B6389F80A92BC97F" modified="2017-01-18" version="1">MFAVYNGSVSDAPTDSGRGGSDRRPIWARPERGTRGPVPAHSRNAIVTAAVALADAEGLAAVSMRAIAAALGTSAGSLYRYLSSRDDLLDLMTDQVVGELQPYPEADGDWLDGMLLLARRQLALYQRHPWLLEVMHRTSGIGPQSLAWFDNCLRVLEPVPCAVTAKFEAIAMMTGLVSLFARSQTASPPFTFDGVDLAVYPHLAAAFTQPPAPTPQGDLFERTLRSLLAGLLVPEPPDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ALW2</accession>
    <name>A0A1H6ALW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49164">
        <property type="protein sequence ID" value="SEG49164"/>
        <property type="gene ID" value="SAMN04489712_105518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG49164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="10795" checksum="1037B76916340FA0" modified="2017-01-18" version="1">MPAPHPPEFRQRAVELARQGGKPISLIAKSLGISESCLRNWMAQADADDNGGPGRLTTAERKELARLRRKTRQLEMENEILKRAAAYFARENVLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B445</accession>
    <name>A0A1H6B445_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CO dehydrogenase maturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55304">
        <property type="protein sequence ID" value="SEG55304"/>
        <property type="gene ID" value="SAMN04489712_106221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="313" mass="33530" checksum="D8095BC129CB4CA6" modified="2017-01-18" version="1">MKVAFVGKGGSGKTTLSSLFIRHLAGRGLPVVAIDADINQHLGVALGLDEGRAAKLPAMGDHLTEIKDHLRGDNPRIGSAAVMVKTTPPGRGSRLLRIGGDDPVHALGEPVDGATLLVTGPFNDDDLGVACYHSKTGAVELYLNHLVDGPGEYVVVDMTAGADTFASGLFTRFDLMFLVAEPTRKGVGVYRQYTEYAADYDVAIKVVGNKVQGEQDVAYLREHVGDDLLTWLGQSAAVRAMEQGRDGIALEEANEAALERMLQAVDACAKDWAKFHRQAVEFHIKNARSWANRAVGEDLEAQIDPGFPLASTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BFA3</accession>
    <name>A0A1H6BFA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58916">
        <property type="protein sequence ID" value="SEG58916"/>
        <property type="gene ID" value="SAMN04489712_10732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045924">
        <property type="entry name" value="DUF6343"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19870">
        <property type="entry name" value="DUF6343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG58916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="86" mass="8876" checksum="FFE980E2C7CB25FB" modified="2017-01-18" version="1">MPLHDRRPAPGTEPLTARSALGTRALLSGVALLAGIAAAVFFGLQAAGGQWPVAGFWAATAICAAVAVIAAVDLWVIRRRSRDTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLL0</accession>
    <name>A0A1H6BLL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-amino acid N-acyltransferase YncA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61564">
        <property type="protein sequence ID" value="SEG61564"/>
        <property type="gene ID" value="SAMN04489712_107224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG61564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="184" mass="19424" checksum="76CC99AA4E0A1AEB" modified="2017-01-18" version="1">MADVGVRPARRADAAAVADIQVRAWREGYRDLLPAAVLAEVTGPQAVAVWRDRWTEAATAPPGPRHRLLVAVSADLVVGFAAHAPATDPDLDPAVTAELVTLLVDPLHGRAGHGSRLLAATADLLREDGFGTVVAWVFEGDTAMRRFLGSAGWAPDGARRTLDMGEPVVMIRLHTDISAGGGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BM08</accession>
    <name>A0A1H6BM08_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="7" type="ORF">SAMN04489712_107237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61703">
        <property type="protein sequence ID" value="SEG61703"/>
        <property type="gene ID" value="SAMN04489712_107237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG61703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="89" mass="10411" checksum="92801CA3192DF09F" modified="2017-01-18" version="1">MSLDTATKNQIIAEYATSEGDTGSPEVQVALLTRRINDLTEHLKVHKHDHHSRRGLLLLVGRRRRLLKYLADKDINRYRQLIERLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BMQ7</accession>
    <name>A0A1H6BMQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_107264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61999">
        <property type="protein sequence ID" value="SEG61999"/>
        <property type="gene ID" value="SAMN04489712_107264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG61999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="27579" checksum="B69458E94D886762" modified="2017-01-18" version="1">MTPVVPPVVEVGDLVVRYGTATALDRVSLTVGAGELVALVGPNGAGKSSLVNAIMGIVRPASGRVRVSGRVALVPEGRQMFGDLSVDDNLRLGAWRRRGRPGARDTSRVYEVLPELTRVRHQRAGTLSGGQQQMVAFGRALMAEPDVVVVDELSLGLAPMVTAGLAEHLRSLNAGRGLAVLLIEQNARLALDLCGRGYVLEAGRIRAQGSADELARSAEVAAAYLGGPATTAEPGGSGPEGTGPDGTKRGAAKGGGTGPGGAVSGREARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BN04</accession>
    <name>A0A1H6BN04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protocatechuate 3,4-dioxygenase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_107270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62064">
        <property type="protein sequence ID" value="SEG62064"/>
        <property type="gene ID" value="SAMN04489712_107270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012786">
        <property type="entry name" value="Protocat_dOase_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02423">
        <property type="entry name" value="protocat_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="4">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG62064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="19697" checksum="35139198FDB4C334" modified="2017-01-18" version="1">MGLPTPSQTVGPFYGYALPFTGGGQIAPTGDPAAVTLHGYVLDGAGEPIPDAILEFWQAAPDGSRAGAPGSLRRDPVTGTVIGRHGLDFTGFGRVPTDADGHYALRTLPPGGAPYISVCVFARGLLHHLYTRAYLADAPGDPLLTSLEPERRATLLATPERDGVYRFDIYLQGNETNEETVFLAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BR76</accession>
    <name>A0A1H6BR76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM family uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62716">
        <property type="protein sequence ID" value="SEG62716"/>
        <property type="gene ID" value="SAMN04489712_107316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="260"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG62716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="640" mass="71667" checksum="CE17FBDA0F9C82E0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYK4</accession>
    <name>A0A1H6BYK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_108136</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Bacterial outer membrane biogenesis; LPS core biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.70" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65794">
        <property type="protein sequence ID" value="SEG65794"/>
        <property type="gene ID" value="SAMN04489712_108136"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00958"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="10">
        <location>
            <begin position="176"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CTP_transf_like" evidence="11">
        <location>
            <begin position="330"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG65794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="467" mass="47834" checksum="D5B97341075B0FC6" modified="2017-01-18" version="1">MRGGPLVVLGDALLDVDLEGTVERVCPDAPVPVVGDVRERRRAGGAGLAATLAAGMAGGAGRDVVLIAPIGADPSGAALAGLLEAEVELLRLPLDGWTVRKTRVRAAGQSLVRVDQGDGRMAGAPVDDRVRETLHGAGAVLVADYGRGVTAHDGLRRILTGVPKDVPVVWDPHPRGAQPVPSVRLATPNRAEARGLVGTPPAGGDPLGQAAADAAALVSQWNAAGVSVTLGERGALLSVGGDAPYVVTAPATGAGADTCGAGDCFSAAAALALADGALLSEAVTEAVHRAAGFVASGTVRGPRDPEPGPAGDPWEAVRHVRERGGTVVATGGCFDLLHPGHVSLLRQARALGDLLVVCLNSDASVRGLKGPDRPVMTEQDRARVLGALDCVDAVIVFAERTPARLLERLRPDLWAKGADYASAELPEAHIVRRYGGQVVLLPYLEGRSTSRLVERVRSRVNDGGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZB1</accession>
    <name>A0A1H6BZB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin-guanine dinucleotide biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_108154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65973">
        <property type="protein sequence ID" value="SEG65973"/>
        <property type="gene ID" value="SAMN04489712_108154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="4">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG65973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="197" mass="20301" checksum="138BCD8CA5CB7C5C" modified="2017-01-18" version="1">MTAAPEFDAVILAGGRARRFGGADKPAARIAGRPLVGWAAAAAAGAGRLVVVGPPRPDPPGAIAVREDPPGGGPVPALRAGLAEVRAPWLVLLAADLPFLRAEQVGELREAAARHGAGAVLVDGDGHPQWLIGCWHAPTLRAAARTYRGTSLRGLLAPLEPLAVSLPAGERPPWYDCDTPESFERARRIAAASPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C0K8</accession>
    <name>A0A1H6C0K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66215">
        <property type="protein sequence ID" value="SEG66215"/>
        <property type="gene ID" value="SAMN04489712_108173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294306" evidence="2">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG66215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="107" mass="11654" checksum="810571F6B99D34AA" modified="2017-01-18" version="1">MRVSCAFHVRSSASAGPAAGAAGAGRHTGAVNESGLEDPAERPRCSAKGCHAAAVWALRWNNPKIHTPERRKIWLACQEHRESLSAFLGRRGFLRDVVPVGELEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1U3</accession>
    <name>A0A1H6C1U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hemolysin, contains CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_108243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66980">
        <property type="protein sequence ID" value="SEG66980"/>
        <property type="gene ID" value="SAMN04489712_108243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="280"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG66980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="36355" checksum="69B31EB66781497B" modified="2017-01-18" version="1">MSNPWVVLAATVAIIALSAFFVAVEFALIAAKRHRLEDAAPTSRSARAALRSASELTVLLAGAQLGITVCTLALGAVTKPAVHHWLTPLLGSWGLAPWPADVAGFVLALIAVTFLHLVVGEMAPKSWAIAHPEKSATLLALPMRAFMWLTRPLLRTLNEAANWCLRKVGVEAADQVASGQDPEALRHLVEHSANVGVLDTVYSAQLSGALDLQHLRLGDLVKKGSTPTAVPAGATVADVQAASRDSGHLRILVAGPGVDRGVVHVRDTLTEPETAGIAHLTRPAYRMSADTTVSTALARMRETSNQLALVTEGDRILGVVTINDVLRRLFLRPGEGRTPATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C748</accession>
    <name>A0A1H6C748_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68830">
        <property type="protein sequence ID" value="SEG68830"/>
        <property type="gene ID" value="SAMN04489712_10923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045991">
        <property type="entry name" value="DUF5947"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19372">
        <property type="entry name" value="DUF5947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG68830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="195" mass="21322" checksum="DD83FC83F2C5B130" modified="2017-01-18" version="1">MTVSALSRVITRAAARSREGAERCELCSAAVPEGHAHVLDERAGEVLCACRACALLFEQDAAADGRYRRVPDRRIRLSGLSPADLGVPVGLAFFVKRPDGGVDAHYPSPLGATRWDVDPDTWSRAVAGCEPLRTIRPSVEALLVNTSQDADEQWLVPIDECYRLVAVVRRHWTGLSGGGQVWKEIEAFFDRLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7S1</accession>
    <name>A0A1H6C7S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase expression/formation protein HypC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68797">
        <property type="protein sequence ID" value="SEG68797"/>
        <property type="gene ID" value="SAMN04489712_10920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="93" mass="9464" checksum="6E9F9260C68F3297" modified="2017-01-18" version="1">MCLGIPGEIVALLPDRADLATVEIAGVRRAVNIGLLGTSGDSGVGVGDWVLVHVGFAMSKIDEAEAAATLALLRGLGEAYTDELDALKGSDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CA28</accession>
    <name>A0A1H6CA28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69834">
        <property type="protein sequence ID" value="SEG69834"/>
        <property type="gene ID" value="SAMN04489712_109119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="463" mass="49746" checksum="F09667488E02C8E3" modified="2017-01-18" version="1">MSRAERRAKITPEGRARGARLRTERDHRGWGRRELARLLLDAIDDRQKPSHVTVASHIKEWEDGGGISAMYRTAYATVFDLPEAELFAPTQATPPLSPSDSGEVRAVQELSQPYSTDPMGTVGVSPVPDFRDDDMRRRAALQLLAALGAGTAIPPGSLEGVLSGIDDALGNPLDLDEWERTVHEYGQLLITRPAGALTRDLTSDIITVGELLRRQLAEPERQRMLRVSAGLSACLAINLGDRGDIRAVRTAWATAIRAADACGDTDLRVWVRGRAAQEACWTGRPTSTVVALADEAVTIADGGPSAGLARAHAARAYAAVAQGDTAQAYASLAKAKRTFDGLPHQDGQSVFAFRQSQLRWTESYVHALSGDRRAHATVAEAESLYPPDAHGPRSNLALMDAAALIQAREVKTGLERAITALERHPDAATAGRASLTGQILRTLPPEARRLPAARELQALTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCP5</accession>
    <name>A0A1H6CCP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70613">
        <property type="protein sequence ID" value="SEG70613"/>
        <property type="gene ID" value="SAMN04489712_109184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="239" mass="24832" checksum="F58749E0B813F00B" modified="2017-01-18" version="1">MTDSPAAKLIAPRPAEPMPKAVDVTLSLSDFVSPSHWVLWALGKICGVNPAEWVGQHVGGDWEPIATVSSALEHVGDFYTAYAGELRRGSTTMLKSWEGNAATACGQYFSDFAGVLKEQEPAIRTVARECRSVAFGAWATSKAVVSALEALCDLAVMIAIEAAASAATGWTVVGPSAGLALIMSQIGAGILLWLDIIGKVGLVVSSVHLLIGVISGLLGAIHGLDAQPFPQGSYGDKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CE67</accession>
    <name>A0A1H6CE67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71123">
        <property type="protein sequence ID" value="SEG71123"/>
        <property type="gene ID" value="SAMN04489712_109243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="325" mass="35599" checksum="54ECEAE90A19A81E" modified="2017-01-18" version="1">MADRPHERPACCAPALSAEVTAAPTFGFDIPRRSPRDVAKGMAAVPGGAFRMGGADPDAFPQDGEGPVRTVRLSPFLIDRYAVANRQFAVFVKDTGYVTEAERFGWSFVFHAHLRPDTPVMDATVPEAPWWAAVPGAYWKAPEGPGSSIERRPNHPVVHVSWNDASAYAAWAGKRLPTEAEWEMAARGGLDQARFPWGDELAPRGRHRCNIWQGEFPVHDTGEDGFTGTAPVNAFAPNGYGLHNVAGNVWEWCADWWSTDWHATESPETRQDPRGPSTGTARVIRGGSFLCHESYCNRYRVAARTRNAPDSTTAHTGFRCAADPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJB6</accession>
    <name>A0A1H6CJB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73018">
        <property type="protein sequence ID" value="SEG73018"/>
        <property type="gene ID" value="SAMN04489712_11061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="132"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG73018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="183" mass="20334" checksum="437A5A95B14BEB9E" modified="2017-01-18" version="1">MTSVSRAGPGDGELVRAAADGDRGAFEELYRRYAPWLRARLRSRCADAALVDDVVQETFLAVWRGTARYHHDGDVAGWLWRIGARRLVDALRGDGARGRLRQALARLRHREEVSAEEHVLTRIEHGDLAGSLERLSPELRAVLQATVIDGLTTREAAALLGIPPGTVKTRAMRARRQLRQELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMH2</accession>
    <name>A0A1H6CMH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/amide ABC transporter membrane protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_110199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74204">
        <property type="protein sequence ID" value="SEG74204"/>
        <property type="gene ID" value="SAMN04489712_110199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG74204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="341" mass="36278" checksum="62CB464667FCF057" modified="2017-01-18" version="1">MILRLLARRPVLLALALVVAFALPWLIYPPVAMDIAAWALFAVAVDLLLGYGGLLSFGHAAFWGTSAYTTGLIALHTGLPFPVAIVGGALAAAVLAVPIGYLSVRLSGIYFAMVTLAFAQMIYFIVNQWRDVTGGENGLQGIPRELFGLDLSDPFLFYYAGLPFVLVGLLVAWRIVRSPFGQVLMSIRDNPSRARALGYPVDRYRLLAFVLSAALAGLGGGVFAISHGFASLHDVYWTTSGQAVMMVVLGGIGTLWGAVLGAALIVSLNDYLATAGFEETGIITGLIFVVIVLLFRKGLWGTARDLTAARSGRHRPAAVPDPPSSASSSERLDQVAERSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CN21</accession>
    <name>A0A1H6CN21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease, subtilisin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_110224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74414">
        <property type="protein sequence ID" value="SEG74414"/>
        <property type="gene ID" value="SAMN04489712_110224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295036" evidence="4">
        <location>
            <begin position="26"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="197"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG74414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="857" mass="88939" checksum="F68644DBF8A62AA5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNH2</accession>
    <name>A0A1H6CNH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein YndB, AHSA1/START domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74307">
        <property type="protein sequence ID" value="SEG74307"/>
        <property type="gene ID" value="SAMN04489712_110211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="16382" checksum="331FAC2B668B0296" modified="2017-01-18" version="1">MSAVESRTVEQTMRIQAPPETVWRYFTDPERLARWWGEAEVDARPGGILRVLMHDGPRPVMRGRFTELVPHERIAFTFGWEPTPGAPDIPPGASRVEITLAGDGDATVLTLRHSGLPFRLHDETDTGWRHLLHRLSTTAAHDHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTM0</accession>
    <name>A0A1H6CTM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Energy-coupling factor transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_111110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76023">
        <property type="protein sequence ID" value="SEG76023"/>
        <property type="gene ID" value="SAMN04489712_111110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="287"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG76023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="533" mass="56505" checksum="844DF33F5DAE19ED" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CXL4</accession>
    <name>A0A1H6CXL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77176">
        <property type="protein sequence ID" value="SEG77176"/>
        <property type="gene ID" value="SAMN04489712_111259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="16111" checksum="EDE5C716F6B10B46" modified="2017-01-18" version="1">MTGSRLVGAIQLPGGSWVRGRGLRHPPPEGPEPVFGLYLGSGRLRRRHEGEMSWQELWVEWPDFLLPRDREQAVQGIRALHGQAGEGQPVEVACGGGVGRTGTVIACLAVLDGLPPAEAVAWARAHHHPRAVETPWQRRWVARFPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZ03</accession>
    <name>A0A1H6CZ03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG77943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77943">
        <property type="protein sequence ID" value="SEG77943"/>
        <property type="gene ID" value="SAMN04489712_1124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG77943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7423" checksum="BB496074488ABEA1" modified="2017-01-18" version="1">MAQGTVKWFNPDKGFGFISPDDGSADIFVHHSAIEMRGFRTLAEEQRVEYTAVQGPKGLQADQVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D019</accession>
    <name>A0A1H6D019_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78632">
        <property type="protein sequence ID" value="SEG78632"/>
        <property type="gene ID" value="SAMN04489712_112103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="268"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG78632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="355" mass="37780" checksum="D8681C08C93A30F9" modified="2017-01-18" version="1">MVRPVPWVPPVLYGAVLAGGVYYAAIGPGLGARTAGYTALLCVLIVLDARERRVPPGLLLAVRVVLFGAVTGLDVSGLSRVLFVLVPFLGYFAFGPMAAVALGAACVAVLVGAFTLTVPNWQVRAEYISDLLMFALGVVLSVTMAAVAVREQRARSRLEATLEQIAELSAARERNRLAREIHDSLGHHLTAIGIQLEKAEAFAALDPAGAAQAVSSARWSAGRALEEVRASVRALDAQGISAALADLVRALDDGERRITLSVSGAERRPLHVLYRAAQEGLTNACRHADATEIRVAVRYHERGAELRVTDDGRGFGDGREGFGLKGLRERVRQAAGTMTVESSSTGTELRVNVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1C2</accession>
    <name>A0A1H6D1C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79189">
        <property type="protein sequence ID" value="SEG79189"/>
        <property type="gene ID" value="SAMN04489712_112180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="60" mass="6848" checksum="3A7B5C6C6145607C" modified="2017-01-18" version="1">MRQQIDLRVHDRVALDEIELYSEILSAVASAERPLTTDEIDMVLGVRPEDVTGRRELTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1F2</accession>
    <name>A0A1H6D1F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_112132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78848">
        <property type="protein sequence ID" value="SEG78848"/>
        <property type="gene ID" value="SAMN04489712_112132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG78848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="227" mass="24639" checksum="63F92092968D7C33" modified="2017-01-18" version="1">MGDMERYRIMVVDDSPIIRSGLTTVLEASNDLEIVGEAGDSRRAVDLAWQIKPDVVLSDMPMPEGDGITSVAMLSEVSRVIILTYADDPDMVLSAIRSGAIGYLVHDTFTVEELTDAIRDTVRSNAHPLSPTAAAALVTAAKAGQCPCVERNPGARREHFGLSARETDVMNLIAQGHTNSSIAAQLFLAEKSVKNYINRIYAKMEAQNRATAIVKWLGIRPDTAIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2N5</accession>
    <name>A0A1H6D2N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clp amino terminal domain-containing protein, pathogenicity island component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78906">
        <property type="protein sequence ID" value="SEG78906"/>
        <property type="gene ID" value="SAMN04489712_112140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="2">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Clp R" evidence="2">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Clp R" evidence="2">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Clp R" evidence="2">
        <location>
            <begin position="320"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG78906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="365" mass="39265" checksum="B06AE0C23E2EF239" modified="2017-01-18" version="1">MRPEPHTATTDASRELRETLVEAFRRAIRDGRPDVGTEHVLFALLDGESAAKDLLAPRVRDSGSLMGVITAKGAEHWVGEDRAGDGEPLGGHAVAALLREAAWAASEDEVPPRPTGALTAALAQALMRAGELGVSRANASHLLMGLLHDRGNRACEALLERRVNRDDLIARLAVHPSARQDGMRNPDGVAGLRNMGMLNERGMYWGRLARVLSSGGFGSPVIPTVRLEAERQAVRLGHSEVTPVHLLLGMLALDDQLAEAGLRLRAEWARTNKGAELLRERGITLAAMVDALAEPSTADPFRPTMHEEIGRLLTRARLRCHERGDPSTGTTHLLAVLVAEPAEPCGPLLASLGVDTAELRQALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D804</accession>
    <name>A0A1H6D804_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin Q/BCP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_113172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80895">
        <property type="protein sequence ID" value="SEG80895"/>
        <property type="gene ID" value="SAMN04489712_113172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG80895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="16797" checksum="0CCDEBF52F93B728" modified="2017-01-18" version="1">MAFMNVGDLVDDFELPDEQGEPRKLSDLLADGPVVLFFYPAAMTAGCTAEACHFRDLATEFAEVGARPVGISADPVSKQREFTGKHGFGFPLLSDEDGEVARRFGVRRGFALAPTKRQTFVIGTDRRVIEIVKSEIRMNVHADRALAALRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8H3</accession>
    <name>A0A1H6D8H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FBP C-terminal treble-clef zinc-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81727">
        <property type="protein sequence ID" value="SEG81727"/>
        <property type="gene ID" value="SAMN04489712_114129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032330">
        <property type="entry name" value="EF-G-binding_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16571">
        <property type="entry name" value="FBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FBP_C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="17661" checksum="914F1C47E714E84C" modified="2017-01-18" version="1">MDPITERDIRACFVNCSKGEAHRAGLPKDLADQPWEALDFLGWRDPGAPGRAYLVAERDGRLVGVALRAVSGGSRGFTARSMCSLCLTVHTGGGVALMTARRTGEAGRQGNTIGQYLCGDLACSLYVRGRRDAAVGGDLDESLTQDAKIARIRANLHAFLDKITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8Z9</accession>
    <name>A0A1H6D8Z9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</fullName>
            <shortName evidence="3">SEPHCHC synthase</shortName>
            <ecNumber evidence="3">2.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthesis protein MenD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menD</name>
        <name evidence="5" type="ORF">SAMN04489712_11491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="2.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="3">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family. MenD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81594">
        <property type="protein sequence ID" value="SEG81594"/>
        <property type="gene ID" value="SAMN04489712_11491"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01659">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004983">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG81594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="557" mass="59215" checksum="2FD082F4709392CB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDS7</accession>
    <name>A0A1H6DDS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dTDP-4-amino-4,6-dideoxygalactose transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83607">
        <property type="protein sequence ID" value="SEG83607"/>
        <property type="gene ID" value="SAMN04489712_11635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012749">
        <property type="entry name" value="WecE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02379">
        <property type="entry name" value="ECA_wecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG83607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="44792" checksum="9E8D85E1D85612E6" modified="2017-01-18" version="1">MTVTASHTAATGTYVPFYIPHLTGREETYLREAFETGQLDSDGTFTERAVALLRRLTGTPHALLTPSCTHALEIAALALDLQPGDEVIVPSWTFAPTASAFALRGAVPVFVDCRPDTLNLDERRLEEAVSERTRAILVMHYAGVACAMDEITAIAGRHGLPIVEDNAHGLAGAYRGRALGTFGIMAAHSFHATKNIQCSKGGALFVNDPALYERTVLIRDRGTNRYQYFRGEVDKYRWVDLGSSYLLSEPLAAFLTAQLEELPRIQRRRREIWAAYHERLAGWAGRTGVVRPTVPPGCEQPAHIYYLVLPGPDSQQALLAHLAEHGVKATPHFQPLHSSPAGLRYGRTAPGSCPVTEWVADRLIRLPLYADMTDSQVDRVVDALTSFQPRPARRPAPGHDDRKEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGY5</accession>
    <name>A0A1H6DGY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted metal-dependent hydrolase, TIM-barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83866">
        <property type="protein sequence ID" value="SEG83866"/>
        <property type="gene ID" value="SAMN04489712_11686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="6"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="398" mass="43930" checksum="BA03997A5DAD0445" modified="2017-01-18" version="1">MEYQLIDADGHYYEPDDCFTRHIEPRFRDQTVRVERGADGLGRIFLRDRRTFMSVMPGDYASAPGALEGLFAGGVADGFTHREVINARDHPAFTERDARLALMDEQGLQATIMLPTLGVAVENDMRDDAELTYASLRAFNRWLEEDWGYGADGRIFAVPMLSLLDVGPAMAELHRVLDAGARLVHLCPGPTGGRSPAHPMFDPFWDTVSEAGIPVVFHVSNSGYQHFYGTRWSEDPGNPSHRQSPLQWALCNTERPLVDTLTALTLHNLFGRHPKVRILSIENGSSWIGHLFKTVDKAAALGRRGPMLGGPLPPRPSEALAEHLWVCPFPEDDVHELIEAIGPGHVLFGSDYPHPEGLREPRDYIPRLAGCDAAVTRKVLRGNTAGLLGLPDHAPAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DH72</accession>
    <name>A0A1H6DH72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted metal-dependent hydrolase, TIM-barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_116108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83946">
        <property type="protein sequence ID" value="SEG83946"/>
        <property type="gene ID" value="SAMN04489712_116108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="64"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="363" mass="40638" checksum="3373439E31F29C03" modified="2017-01-18" version="1">MAPAEYRDRVPRVEEVDGRLMWVFDGQPVGRFSAGGVVARDGSKEESEIALHSWTIDQIHEGAYDPTVRLQVMDECGIDAQVIFPSTIGLGGQSLAMVEDERLRRLTVEIYNDRQAQIQADSGDRLLPLPLMPAWDVDACVYEARRVAALGARGVNMTSDPQDLGSPDLASPAWDPFWEACTEARLPVHFHIGASVTNMTFYGKYPWPSHPPSTRLAIGGTLLFIGNARVVANLLVSGVFDRHPDLKMVSVESGCGWIPFILEALDYEMAENAPSDLAKLRKPPSEYFRSNLYATYWFESNRHKLPALVESVGEDNILFETDFPHPTCLYPNPVERAQETMKSLSDETRRKILGENARKLYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIP0</accession>
    <name>A0A1H6DIP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_117123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85049">
        <property type="protein sequence ID" value="SEG85049"/>
        <property type="gene ID" value="SAMN04489712_117123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="26211" checksum="5C66C9DF6BCBCF7B" modified="2017-01-18" version="1">MQISGSSAVVVGGAGGLGEATVRRLHAAGAKVVVADLADDKGKALEQELGVRYVRTDATDEGDVQAAIAEAEAAGPLRISVDTHGGPAIGGRLVNKNGEPLDLAGFRTTIDVYLTGVFNVMRLAAAAMARQEPADGDRGVIVNTASIAAYEGQVGQLPYAAAKGGVVGMTLVAARDLSPLGIRVVTIAPGTFLTPAYGKAGDQLEAHWGPQVPHPRRMGRSPEYAALVQHICENDYLNGEVIRLDGALRFPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJ37</accession>
    <name>A0A1H6DJ37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85487">
        <property type="protein sequence ID" value="SEG85487"/>
        <property type="gene ID" value="SAMN04489712_11815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="29607" checksum="A5C17009FA3C466A" modified="2017-01-18" version="1">MAGYQCLTFLTDYGLEDGFVASCHGVAARICPGVRIIDITHLVPPGDVRRGATVLAQTVPYLPPGVHVAVVDPGVGTTRRGVAIDIGGQVFVGPDNGLLSWAVHVAGNGPVRAYELTNTELWLEPVSATFHGRDIFMPVAAHLVNGLDLAAVGRALQLEELVMLPPPVRRIRENSVEGEVLTVDRFGNIQLSVTAADLERLGIRKGGVVLLSLGRRKLSVPYQWTFGSVAPGELVAYADSAGCVALAVNAGDAAQRLGLPPGAHVRIAPAPDSFAPTGVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKL4</accession>
    <name>A0A1H6DKL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85880">
        <property type="protein sequence ID" value="SEG85880"/>
        <property type="gene ID" value="SAMN04489712_11898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG85880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="32910" checksum="D59D9AFD0CC3D873" modified="2017-01-18" version="1">MDDAVTLRDVSDTALVAAVVRARESARRDPLFRDPYAEALAGERGSRLATGAQLRIISSGVVARTAVYDELITRMVREEGVGRVLNLGAGLDTRPYRLDLPEDLDWVEADLPGILDHKEQVLADARPRCRLTRARVDLSDAAARRRLLDEVSGGPPVLVVCEGLIAYLDADDVTGLARDLAERPALRWWALDMIGPLFVQVAKKIAGRRMERAEASLRFVPQEGAAFFRPLGWEPVDVRSSWVERRRLRREPPLMRAIWTVSPPRTREFFRQQGMFVLLRRAEDTGGAERGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLW4</accession>
    <name>A0A1H6DLW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_11914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86194">
        <property type="protein sequence ID" value="SEG86194"/>
        <property type="gene ID" value="SAMN04489712_11914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="42"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="126"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="232"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG86194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="409" mass="44129" checksum="37C2F606D567C6CF" modified="2017-01-18" version="1">MSAALQLEELLRQVLPARWTELVDSDDREGLADYLAGLDADLSTDLVRTVAADGWLVPEWPTHLGGRALSADETVDVRRTLARWRVGTVDSAIGTGWVGPAILTFAGDDVAAELLPSIARNEVLWCQLFSEPEAGSDLASVRTRARRDGDRWHLTGRKTWTSRADRAGWGLAVARTDIDVPKHAGLTCFLVDLSTPGIQVRPILQMTGDAEFFEVTLDDVVVPDRYRLGETGQGWEVVRTVLQLERMAGSGAGAATPGSVVGRTVDELVAERLPGSDPVQADAIVRLYVEAQAIALNNRRNALHRSEGLPPVANGTPYNKVLQAEHTKRLQRGILGSAGLGAVAHAPGDRARSYDAWAFLRVQPKTIAGGTSEVLRDQIAERALGMPRGADPSKTVSWREFTGSRGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DM07</accession>
    <name>A0A1H6DM07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86181">
        <property type="protein sequence ID" value="SEG86181"/>
        <property type="gene ID" value="SAMN04489712_1199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="28456" checksum="17DAD55ACA3F57E4" modified="2017-01-18" version="1">MSDAQDTTPSAATTDARDAPEVLVEDREGVLVITLNRPQAKNAMTQTMARVIASALDRLDDEPALRLAVITGSGGSFCAGMDLKGFLRGERPSIPGRGFGGVTEAPPRKPLIAAVEGWALAGGFELVLACDLVVAASTARFGIPEVKRGLVAAAGGLHRLPDRLPEVVAMELALTGDPVSAERLHALGLVSTLTDEGGALDAALALARTIAANGPLAVATSKQIIVESRTWPREERFTRQQPYVDEVLQSNDAQEGARAFTEKRPAAWTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DME7</accession>
    <name>A0A1H6DME7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_118128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86003">
        <property type="protein sequence ID" value="SEG86003"/>
        <property type="gene ID" value="SAMN04489712_118128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="606" mass="67042" checksum="68F6C4F65C237AA0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNW7</accession>
    <name>A0A1H6DNW7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="9" type="ORF">SAMN04489712_12045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86979">
        <property type="protein sequence ID" value="SEG86979"/>
        <property type="gene ID" value="SAMN04489712_12045"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="156"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG86979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="27730" checksum="2518A46B872E61EB" modified="2017-01-18" version="1">MDEKTTADTTAAPGVSGAQPGLPRGGWRRVLLKLSGEAFAGAEPLGIDPAVVQHIAKAIADAVREGTQVAVVCGGGNMFRGAQMAERGMDRGRSDYMGMLGTVINCLALQDFCEKLGLDTRVQTAITMGQVAEPYIPRRAIRHLEKGRVVIFGAGLGQPFFSTDTCAAQRALEIGAEAVLKGTQVDGVYDADPRKNPDAVKFDRLDYGEVLQRGLKVMDATAISLCMDNNLPIVVFDLMGQGNIIRAVRGDKIGTLVGPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPA9</accession>
    <name>A0A1H6DPA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86385">
        <property type="protein sequence ID" value="SEG86385"/>
        <property type="gene ID" value="SAMN04489712_11967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="27202" checksum="2E6A6CCF4C5E9A84" modified="2017-01-18" version="1">MSSGLPFTDLNHVLTTTRAVRLRLDYDRHVPVGVIGECLQLALQAPTGGNAEDWRWVVVGDTERKAELAELYLAAYEEYVCKPLHSAAGAEAQEVKGRLGGVGADGQVSDRTRRILRGADHLARTIGRAPYLVIPCATRPDPAEGASGTGSALYGSIYPAVWQFNLALRARGLGTVITTLHLHHARQAAEILGIPDGVLQIAMLPVAYTKGTGFKAASRRPVNQVAYLDGWGERFPYEDKPFDRVTGEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DS63</accession>
    <name>A0A1H6DS63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88109">
        <property type="protein sequence ID" value="SEG88109"/>
        <property type="gene ID" value="SAMN04489712_12178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="163"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG88109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="28014" checksum="6EC9CD4DAA0DE288" modified="2017-01-18" version="1">MRLGFIGAGRMGRPMVHRLIEAGHEVRVLGRSAETRAALAQEGVQALAGVTEVAGGADAVVVCVFTDEQVREVCLDGGLLTAMPEGSVLVVHTTGSPGTAETLAARAASRGVHVVDSPVSGGPHDIAAGRLTLFVGGADDAVARVRPALRSYGDPVLHVGPTGAGQRVKLVNNALFAAQLGLLADAVRLGAQLGVDEAALLGALPHGSSASRALAGVAARGSVAAFAAAVGDFVGKDVEVARKVAAELGGDLGVLDEALGTLADAVRPAGRSVPQEGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTK8</accession>
    <name>A0A1H6DTK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88608">
        <property type="protein sequence ID" value="SEG88608"/>
        <property type="gene ID" value="SAMN04489712_12242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="14700" checksum="9CFC4ED92FE130FD" modified="2017-01-18" version="1">MTPKAWLFDVDGTLLDSVTGTSLRPLARELLAGLRERGIPVLLWSAGGDDYAWRRARQAGIAEFVTAAHVKAGRDGRGHWVLPHLPPEHIPAVLVDDQPHEVPPVGEVIGVPPYVGPNPRDTALAALLDELERNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVL5</accession>
    <name>A0A1H6DVL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, DUF305 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89321">
        <property type="protein sequence ID" value="SEG89321"/>
        <property type="gene ID" value="SAMN04489712_12367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="57"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="23201" checksum="96FFF46BD2159C41" modified="2017-01-18" version="1">MTEATEAAAATQATAAAPPRGRRVSLVLAALVAVVAVIVVAVSVLRPGGPGPDSPEAGFARDMSTHHAQAVRMSFLVRDATEDEAVRLLAYDIINTQSAQIGMMTAWLDQWEAPKVDPGGSMRWMSGHGGHGGGPAATMPGMATREQLEELENAEGRAAEVLFLKLMIAHHRGGVSMAEAILSRTDHKQVERLARTMVQGQRSEVDLMNTMLRERGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVZ8</accession>
    <name>A0A1H6DVZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3alpha(Or 20beta)-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_122104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88906">
        <property type="protein sequence ID" value="SEG88906"/>
        <property type="gene ID" value="SAMN04489712_122104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="25355" checksum="BE883962E843FEE6" modified="2017-01-18" version="1">MSGRLSGRVALISGAASGMGASHARAFVEHGAHVVLGDIADEAGGELAAELGEAAVYVHLDVTQAADWAAAVAEAVERFGGLNVLVNNAGILDGGPLGTYTEQQWRRILDINLTGAFLGLSAARDALVAARPSSVINISSAAGMQGVAGMHGYTASKYGLRGLTKSAALELAADGVRVNSVHPGAVLTPMIAGMAAEYGVSQVDRTQSTLTRMALPEEVTALVVYLASEESSFSTGAEFLVDGGMTAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWM1</accession>
    <name>A0A1H6DWM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89123">
        <property type="protein sequence ID" value="SEG89123"/>
        <property type="gene ID" value="SAMN04489712_12325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="14222" checksum="4061F7586E7FBC7C" modified="2017-01-18" version="1">MPAGRTGPVGAVRGILTFDGNTTDVAQARGFVDSTLRHHPDRETAVLLTSEFVTNGIVHGTGAITVVVLETESGVRIEVTDAGSGKLPRMRESGVDAEGGRGLFLVDHLASRWDHVRTDAGLTAWFELDTTAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXH4</accession>
    <name>A0A1H6DXH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclohexanecarboxylate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90042">
        <property type="protein sequence ID" value="SEG90042"/>
        <property type="gene ID" value="SAMN04489712_12522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="449"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="538" mass="57486" checksum="AEA5F3D68F58C876" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXH5</accession>
    <name>A0A1H6DXH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG89978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89978">
        <property type="protein sequence ID" value="SEG89978"/>
        <property type="gene ID" value="SAMN04489712_1254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="415" mass="44799" checksum="8D11A999026E241A" modified="2017-01-18" version="1">MPEVLFSVDQARSMRDQSVPGHNRWHPDIPPAATVRPGAEFRLECRDWTDNQIGNNDSANDVRDADLTVCHMLSGPIAVEGAEPGDLLVVDILELGPVPQETGPVSGQGWGYTGIFARHNGGGFLTDYYPDAYKAVWDFHGQAATSRHLPGVRFTGITHPGLVGTAPSPELLARWNAREQALIDTDPERVPPLAMPPTADTALAGTLTGEAAARVGREGARTVPPRENGGNQDIKNFTRGSRVFFPVYVPGALLSTGDLHFSQGDGEITFCGAIEMGGFIDLHVDLIKDGMGKYGVTDNPVFMPGNVEPRYAEFLSFVGISVDRRSDTNHYLDATVAYRNACLNAIEYLKTFGYSGEQAYLLLGGAPIEGHLSEVVDVPNACCSLYLPTAIFDFDIRPTAEGPRRADRGRCAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZA8</accession>
    <name>A0A1H6DZA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90677">
        <property type="protein sequence ID" value="SEG90677"/>
        <property type="gene ID" value="SAMN04489712_1276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="82" mass="8308" checksum="4DED2E1F58708B9D" modified="2017-01-18" version="1">MSGSGSHGGRPSSWLVFTISMTGFIVGGVALCIGPNWMMFWAGVVIVAVSGVLGLAVGIMSDVVLDKPRVARDALADPSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0I1</accession>
    <name>A0A1H6E0I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90415">
        <property type="protein sequence ID" value="SEG90415"/>
        <property type="gene ID" value="SAMN04489712_12630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="195" mass="21131" checksum="3B8950E05A86640B" modified="2017-01-18" version="1">MPGTRAQQREQTRRALLREGRRLFAERGYGSVGLAEIVQATGVTKGALYHHFDGKAALFRAVLEQVQQEVAEAVARAADEHDDPWTRLTAGCRAFLAASTDPDVQQIMLVDGPAVLGWAEWRAMDEAASARHLAEALADLVEKGIIARQPVAPLTHLLSGAMNEAALWLAASRDPGDLSATQAALTRMLDALRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0M2</accession>
    <name>A0A1H6E0M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90546">
        <property type="protein sequence ID" value="SEG90546"/>
        <property type="gene ID" value="SAMN04489712_12668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG90546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24348" checksum="096F2B320E0D7C22" modified="2017-01-18" version="1">MTSDDGARPQRTDRRFTGDPTRARLLEAALDSFSTKGFHGTSTRMIAARAGLSPAAVYVHHRTKEEILFQISRDGHQEALDVVLAAIDSEATPPGRLRAIVRDFATWHARRHTLARVVQYEMAALTPEHADLIAALRRHTHNAVRGVVLAGIERGDFTVRDPESTTVALLSLGIDVARWYRADGAWTPQRVGEDYAELALRLVGHSPGASRNQDDEASLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0P3</accession>
    <name>A0A1H6E0P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional DNA primase/polymerase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG90991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90991">
        <property type="protein sequence ID" value="SEG90991"/>
        <property type="gene ID" value="SAMN04489712_1289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="11"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="295" mass="31444" checksum="DA1494012433947C" modified="2017-01-18" version="1">MTNAPGLMTAALTHAERGWCVFPLRPGDKRPALRADWERRATAADKARIRRCWEHAAYNVGIACGPSGLIVVDLDVPKAGERPPAEWAREPGIWDGADVFATLCERHGQPFPFDTYTVLTGRGGMHLYFTEPAGLELRNSAGRLGWLIDTRARGGYVVAAGSIVAGRVYTVVNDADPAPLPGWLAALLTASSRPAYGAVRMPEIPQDHAAGYAGSALRGEVQRVLDATPGNRNHTLNQAAFALGQLAAAGMLPEPLVFDCLFAAGQHIGLSARECEATIRSGLMSGARRPRMGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0T9</accession>
    <name>A0A1H6E0T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-related sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91182">
        <property type="protein sequence ID" value="SEG91182"/>
        <property type="gene ID" value="SAMN04489712_12856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15629" checksum="E955969BBAD0B0EE" modified="2017-01-18" version="1">MTGRPPGARSIDDILADARRRLVRLEPAEAYKEFSVGDGLLVDIRPQAHRAAEGEVPGSLIIERNVLEWRFDPAGQARLPEATGYDVRVIVLCSEGYTSSLAAAALHDLGLLRATDVVGGYRAWRSAGLPTTGAPWPAAPDPTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E103</accession>
    <name>A0A1H6E103_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell envelope-related function transcriptional attenuator common domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90843">
        <property type="protein sequence ID" value="SEG90843"/>
        <property type="gene ID" value="SAMN04489712_12755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="152"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="428"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG90843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="545" mass="58002" checksum="B502DEE634A3D908" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E357</accession>
    <name>A0A1H6E357_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Large conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_13230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92118">
        <property type="protein sequence ID" value="SEG92118"/>
        <property type="gene ID" value="SAMN04489712_13230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG92118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="134" mass="14614" checksum="6A4F2BA1AC3AF396" modified="2017-01-18" version="1">MEGFKKFLLRGNLVELAVAVVIGAAFGTLVTNFVTAFITPLIALVGGQPDYRSLSFTVNGTAFPYGVFLTSAISFLIIATVVYFLVVLPVAKLLTLLQRKEEAITRDCPYCFGEIPNKATRCRFCTSEVEPVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3T2</accession>
    <name>A0A1H6E3T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92292">
        <property type="protein sequence ID" value="SEG92292"/>
        <property type="gene ID" value="SAMN04489712_1337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="72"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="27691" checksum="8A807D3AA2ACCAAE" modified="2017-01-18" version="1">MDETRKPTLIASVQRALHLMEAVASHPNGAPAKQLAREARLPLATTYHLLRTLAHEGYASRLPSGVWVLGDRLQTLQGRSSTQRLLSRIRPALVALRDELGAAAYFGLHEDGEIRIIDIADGPRTPRVDLWVGFEEAAHATAIGKCVLRQLDDDRRLEYLSRHPLVDLTPNTITEPRELLRALRTPGELALDREEYALGTGCAAVPVTDATGSVVGALAVSCRPSRLPKIEAAASRLRATAARLQRAITLTLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7L4</accession>
    <name>A0A1H6E7L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93712">
        <property type="protein sequence ID" value="SEG93712"/>
        <property type="gene ID" value="SAMN04489712_14019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="27208" checksum="1C17BDC6D10D9BAF" modified="2017-01-18" version="1">MEFTRAEVCIVAASESWRGAGEVLAHAVGIVPAVSARLARLTHSPDLVLSDGEAFFMSEPPPLGGTAADGGVIEAWVPFRSIFDVLQSGRRQSMMGASQIDRYGNQNISAIGDWRRPKRQLIGVRGAPGNTVNHRTDYWVPGHSPKVFVERVDIVSGVGNDRARAGGSTAQRFHDLGVVITDLAVLDYDPEGHLRIKSVHPGVTVEQVQQQTGFPIDGTDATETRTPTPEELRLIREVIDPKSLRSREVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7P2</accession>
    <name>A0A1H6E7P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Amino acid/amide ABC transporter membrane protein 1, HAAT family /amino acid/amide ABC transporter membrane protein 2, HAAT family /amino acid/amide ABC transporter ATP-binding protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_13630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92964">
        <property type="protein sequence ID" value="SEG92964"/>
        <property type="gene ID" value="SAMN04489712_13630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="673"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="705"/>
            <end position="712"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG92964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="925" mass="96483" checksum="706472FD1A37FE14" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E956</accession>
    <name>A0A1H6E956_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000044">
        <property type="protein sequence ID" value="SEG94237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94237">
        <property type="protein sequence ID" value="SEG94237"/>
        <property type="gene ID" value="SAMN04489712_14421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="32421" checksum="5FA376DF58ECC22C" modified="2017-01-18" version="1">MRVFVTGGTGALGRHAVPELVRAGHSVSALARTPEKAALLASWGAEPVEVSLFDPDALATAFHGHDAVANLASAIPSPARFISARAWRAATRVRTEGSAAVTDAALAAGVEVLIQESVCMIYRDHGAAWIAEDAPVDRYPISAGNHAAEAAARRFTEAGGTGVVLRFGVFYGPGATHSEQMYAQARRHVGLLVGRPGDYMSSIHMVDAGTAVVAALGAPAGTYNVVDDRPLTKREYADALARAAEASMWLRVPGRAALLFGARLTSLTRSLRVANTRFRDTTGWAPRYPSAVEGWTATAKALRTPQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9N8</accession>
    <name>A0A1H6E9N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93674">
        <property type="protein sequence ID" value="SEG93674"/>
        <property type="gene ID" value="SAMN04489712_14010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="302" mass="31323" checksum="A66F44EF4306A372" modified="2017-01-18" version="1">MNEICAGRIVIVTGAGRGLGRAHALELARQGARVVVNDLGAGLDGAGRSTGPAHEVVEAIRAMGGEAVANGDDVADFGGARRLVQQAIDTFGGLDALVNNAGFLRDRMLVNTSEEEWDAVVRVHLKGHFAPLRHAAAYWRAESKAGRARRARVINTSSGAGLQGSLGQATYSAAKAGIAALTLVAAEELARYGVTVNALAPSARTRMTEGAFAEKMAVPDSGFDAMAPDNVSPVVAWLASEDSADVTGRVIEVEGGRICVEDGWRHGPAVDLGRRWAAADVGAAVRDLIRKSPAPEPVYGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9Z4</accession>
    <name>A0A1H6E9Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p-aminobenzoate N-oxygenase AurF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000049">
        <property type="protein sequence ID" value="SEG94620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94620">
        <property type="protein sequence ID" value="SEG94620"/>
        <property type="gene ID" value="SAMN04489712_1497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="38695" checksum="B4C0EDB777942938" modified="2017-01-18" version="1">MTKPPTQLAEELREQVGDRKSYLGVIDRLNKASVDKHWEAYADIPWDDPDFQVDPEDPRWVMSPQLDPLARTEWYRSQPVEVQARIGLWRVATAMKIGLQFENLLKRGLLNYAYWLPNGRPEFRYVYHETTEECHHGMMFQEFVNRTGLPIRGMPRSLTLLAQVAPWIPLISTELFFVFVLGGEDPIDFVQRKSLKGGHVKHPLEQTIMKIHIAEEARHISFARHYLRHRVPNLSGPQRRMLGVAAPLVLGLMARIMLCPPGPMVRHFGIPDEVVKEAYGSSEFKGQLRDCVAKIRDLMAELGLITPVNKRIWAALGIWDKPRVRAAAGRAATGRAAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAQ1</accession>
    <name>A0A1H6EAQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93996">
        <property type="protein sequence ID" value="SEG93996"/>
        <property type="gene ID" value="SAMN04489712_14221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="11088" checksum="F065D57718E3BEF7" modified="2017-01-18" version="1">MAEVSLPNGTEWIVGSGVHRWNVPFAAADLSPLTLDSTFGEVADRSGGLKAVTDAIAARRPEFAEFIEVGMNAVEPKTKARDALGMIPDAEPILRDVELALGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJY1</accession>
    <name>A0A1H5SJY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="3 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="11" type="ORF">SAMN04489712_101238</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3 10"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50744">
        <property type="protein sequence ID" value="SEF50744"/>
        <property type="gene ID" value="SAMN04489712_101238"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF50744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="18145" checksum="DCF095209D91E3BD" modified="2017-01-18" version="1">MKRPVAVLIGPPGSGKTTVGRALAERLDLPFRDTDADVEAVAGKPIGEIFVDDGEEHFRGLERAAVAAALAEHEGVLALGGGSILDAGTQRLLAGHTVVYLRVGLSDAVKRVGLAAARPLLVLNPRSQLRTLMEERLPIYERLAVIAVTTDGREPADLAAELAETLQERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SU33</accession>
    <name>A0A1H5SU33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53478">
        <property type="protein sequence ID" value="SEF53478"/>
        <property type="gene ID" value="SAMN04489712_101344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF53478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="19310" checksum="07A354158CA65E4E" modified="2017-01-18" version="1">MLADPTTPQSAPPGTDLLVGGASAERPAAGPVVGSFRRGPFTVLKMAGPLQAGTVVTAEAELLSTIVLAPPPLHLALDLTEVTAIDARGAVLLAKTRFAVRAARGTLHLVAPTDSPVYTALHLGTTGSVMRWATDLTDLLARHAGQDHPAPAERLAEDARAADRNPGPQAVRPVPPPSTGPRAGAAASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SVF8</accession>
    <name>A0A1H5SVF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53851">
        <property type="protein sequence ID" value="SEF53851"/>
        <property type="gene ID" value="SAMN04489712_101358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF53851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="445" mass="47065" checksum="D99BAAB4085E6E72" modified="2017-01-18" version="1">MTDNGNGKGNAVLTKTAAAENGGNGGNGGSRGRFAGLGERARLRAAQSPVWARPVVMALNLVFAPFGVVADVLRDWWSVQGRGMRWVVYGLLVLFALVLPSDVIGDVMSPHTEWQTLLFFPIGGYILLAIGLNVVVGQAGLLDLGYVAFFAVGGYTMAIFGKYHGWNFWEILVVGVLIAALSGIVLGAPTLRLRGDYLAIVTLGFGEIIRISAQNWDYVNGPNGISGIPHPPNLSEWSFPDGQPWEFLGVAGMSPFTYGALDGRPYYYLMLVVIIAVIIFCKRLENSRVGRSWAAIREDEDAAELMGVPTFKFKLAAFAIGAAIGGAAGVVYGSQATSIIPNNFPFILSATILAAVVLGGSGNLPGVMVGAFLVAWLPEYFRGLAEYRILIFGGALVVMMALRPEGILPSRRRQAELAEGTGGMGSLGAEVGGPDTHAAAVEGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T4D1</accession>
    <name>A0A1H5T4D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RF-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57625">
        <property type="protein sequence ID" value="SEF57625"/>
        <property type="gene ID" value="SAMN04489712_101478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCRF" evidence="3">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF57625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="26293" checksum="BE61672376094560" modified="2017-01-18" version="1">MLGELLGPAEDDALVSECHAELGALAPRLSGLRAQVPPLHDEREAIVVVGSDAQEAESWAEELACRYAGRAERGGRSVRVYTRGHSWFGPRATVMRIGGAGAFGWLAAEAGVHRCDRAADRPVLEAWVEVLPMAVSYDFVRIPDEEVRVEDFPETWGCGARLPDWNRSVRLTHLPTGLVAFCQGQGSTTRNRAGAMTLLQALLLRLRHAADDPPEENRTQGSQAGNETGEGMKRRLESDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T7A8</accession>
    <name>A0A1H5T7A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58634">
        <property type="protein sequence ID" value="SEF58634"/>
        <property type="gene ID" value="SAMN04489712_101509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF58634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28162" checksum="EF2F5A1122344F02" modified="2017-01-18" version="1">MAAHGATSMTPQEPLVGLTLDQGVARIHLNDPRHRNALSKRLSDDLAAAVDEALSRGARALVLTAEPPVFCAGGSLEGLLERRVPLAEMYAGMNRLARAPVPTIAAVGGPAIGAGVNLPLACDVVIASDSARFDPRFLDVGIHPGGGHLWRLGRRVGPQGAAALVLCGDVLTGREAAEHGLAWRCVGDADLEATALGLARRAAGRPAALVRRTKESLRAAAVLTDVEEAAELELRAQQWSVEQPEFTETVRRIRRDLAARAGSRRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TG56</accession>
    <name>A0A1H5TG56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60997">
        <property type="protein sequence ID" value="SEF60997"/>
        <property type="gene ID" value="SAMN04489712_101581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF60997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="27841" checksum="2AFFB674DAFE5116" modified="2017-01-18" version="1">MSVYPWVAAYAFRRHATYWLGAVAEAVTNTMFGFVRAWIVLALWGARPALGGYDAADAVTFCFLTQALIGPVQVFGGLELTQRIRSGDVAIDLHRPVDLQGWWLADDLGRAGAALLLRGALPTLAGALAFDLRLPGPAGWAAFAVAVVLAVVTGFGLRYLVALAMFWLHDDRGLQAVALVASMFFSGMLLPLVAFPGWLGTLAQALPWAALIQVPADVLLGRYQGAELAAAYGFQALWAVVLLGAGRALTAAARRRLVIHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TGR1</accession>
    <name>A0A1H5TGR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted kinase, aminoglycoside phosphotransferase (APT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61197">
        <property type="protein sequence ID" value="SEF61197"/>
        <property type="gene ID" value="SAMN04489712_101587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="45"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF61197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="323" mass="35051" checksum="8009BFD11A4704B2" modified="2017-01-18" version="1">MDLREIVAPLAELLAERYGPDVQVAGLRRAAGGASRITCVFDAVTASGRAHPLVLRLATPAAGFSGGPLPREAALMRAARRAGVPSPEVIVDGTAEGPLGAEFVVMERVEGETIPRRILRDPALAGTRSRLAAECGRILAAVHSVPVTAVPGLERDDGLGRWRDLLDAAGEPHPVLEFALRRLEADRPPPHPPALVHGDFRNGNLVIGPEGVRAVLDWELAHIGDPLEDLGWLCVRAWRFGAAEPVGGFGPYDQLVEAYEEAGGVRVDRDALRWWEMYGVLRWAVICLMQARRHLDGSERSVELAAIGRRVAENEWDLLQMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TIN4</accession>
    <name>A0A1H5TIN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Proteasome core protein PrcB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prcB</name>
        <name evidence="5" type="ORF">SAMN04489712_101634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62626">
        <property type="protein sequence ID" value="SEF62626"/>
        <property type="gene ID" value="SAMN04489712_101634"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_B">
        <property type="entry name" value="Proteasome_B_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5009356408" description="Removed in mature form; by autocatalysis" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023234835" description="Proteasome subunit beta" evidence="3">
        <location>
            <begin position="49"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3 4">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF62626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="29196" checksum="51515700E2A55D3A" modified="2017-01-18" version="1">MTGSAEGRGLPPEFFAVGTASFTDLIRRSAPGLLPVNRVGEGPDIPHGTTILALRYPGGVMVAGDRRATSGNVIAQRDLEKVYPADEHSAVALAGTVGLALEMVRLLQVELEHYEKMQAAKLSLPAKARRLGAIVQANLAYAMQGLAVVPLFAGYDLDAGTGRIYSYDVTGMPQESTDFHAEGSGSPFARGSLKKLYRPDLTEDEAAAVCVQALYDAAEDDSATAGPDLARRVFPIIAAVTADGYRRLPEEDVAALAESVVAARHERPDGPVAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TJ83</accession>
    <name>A0A1H5TJ83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62942">
        <property type="protein sequence ID" value="SEF62942"/>
        <property type="gene ID" value="SAMN04489712_101644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF62942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="339" mass="36110" checksum="3ABF8A0DDB163D39" modified="2017-01-18" version="1">MTLEDVARSAGVSLATASRVLGGTARVREDLRERVLAAADRLSYIPNAHARALAGSSSQVVGVICHDVSDPYFAGIAGGVMRAAAAHGLLVMLASTFRDPAQEVAYLSMLRAQRARAILLIGSGFEDRAWERAMNAELEPYLRSGGRVAVVSRHRALKVDAVLPENRAGGAALARAMLDLGHRDFAVLSGPRTLTTVADRLAGFREALAEAGVELPDDRIVEESFTRDGGYAAATELIRRGVRATCLFAVTDVMAVGALAALRDHGLRVPQDVSLAGFDDIPIVRDLTPPLTTVALPLAEMGERVMALALRETRGSRARIERVGGEVILRPSTAPPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TMR9</accession>
    <name>A0A1H5TMR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lsr2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64066">
        <property type="protein sequence ID" value="SEF64066"/>
        <property type="gene ID" value="SAMN04489712_101682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF64066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="11874" checksum="1A5582D379ECC2B4" modified="2017-01-18" version="1">MAQKVQVLLVDDLDGGTADETVKFGLDGAEYEIDLSGDNAKRLREALDPFVDHARKASRGQGRSRKARPTGSRERSADIRAWAKARGIQVNERGRIPASVVEQYEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TS20</accession>
    <name>A0A1H5TS20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64881">
        <property type="protein sequence ID" value="SEF64881"/>
        <property type="gene ID" value="SAMN04489712_101705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF64881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="42202" checksum="83A38DC567F4D024" modified="2017-01-18" version="1">MSDPTPPVSDLDLFDDEVLVDPYPSYAALRALGGVVRLPANDVYALTRYDVIRNALGDWESFSSAGAIGFNPTVNEALTGTSLASDPPVHTRLRATLTANLSPRALRGLKDGIDAKADAFVAELVDKGSFEAIDALARAFPLEVVADLIGFTGHVRDNMLRWGQAAMQVIGPMNRRTAESFPIAGELYDWCSGVTADDLAPGSVGRGIFEAEARGDIPPGTSGHIIHQYLGAGVDTTIASIGNLVALFAAHPDQLARVRENPSLVSAAFNEVLRYWAPVHAWGRRTTRDVEIDGVLVPEGAQVAILFGAGNRDPRHYENPEEFLVERNPTDHLSFGYGPHGCAGQGLARLEAHAVIKALSHRVERLVVGTEVRVPSNITRSIEKLPVLEVIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TYB0</accession>
    <name>A0A1H5TYB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67824">
        <property type="protein sequence ID" value="SEF67824"/>
        <property type="gene ID" value="SAMN04489712_101794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009285548" evidence="2">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF67824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="10205" checksum="AC68559808508289" modified="2017-01-18" version="1">MSMKPGIRLWSKVSSVSVVVVRPAAGEVTLTCGGVPMIEHEPQNAAATAEGEGPLLGKRYTDEDSGLQVMCTRGGAGELAADGRPLQMMNPRPLPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TZ84</accession>
    <name>A0A1H5TZ84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Simple sugar transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68116">
        <property type="protein sequence ID" value="SEF68116"/>
        <property type="gene ID" value="SAMN04489712_101805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF68116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="36208" checksum="F78694A18F33E2E4" modified="2017-01-18" version="1">MNRADAPSRHLGILKHSLFWPVTVLIVMLLANVIFTRDFLAIRIEQGHLYGSLIDILLFGAPLILVALGMTMVIATGGVDLSVGATVAISGALACDLIAKGHGLPVAIGAAIGASLLLGLWNGLLVTRLGIQPIIATLILMVAGRGIAQLITGGQIITINNQGYKLIGGGYWLGLPFAIILVAVALVVTVVLTRRTALGLLIESVGGNAQASRLAGIRSSGLIVLAYVFCGLCAGVAGLMISSNTLSADGNNAGLWIELDAILAVVLGGTALTGGRFSLAGTVLGALIIQTLDTTIYTAGIPPRTTLVFSAAVVTIVCLLQSPAFRARFTRKRPERPADPVSTGPKQEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5US73</accession>
    <name>A0A1H5US73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF77972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF77972">
        <property type="protein sequence ID" value="SEF77972"/>
        <property type="gene ID" value="SAMN04489712_1021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="108"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF77972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="411" mass="45927" checksum="6544E6F2986B9547" modified="2017-01-18" version="1">MEDWAEIRRLHRSEGMPIRAIVRKMGVGRNTVRRALASDAPPKYVRKRKGSIVDVVEPQIRELLSSWPDMPATVIAERIGWERSMTVLKDRVRELRPLFAPPDPVSRTQYRPGELAQCDLWFPPVDIPLGSGQSGRPPVLVIVSGYSRWISARMIPSRQAPDLLAGHWVLLAQLGAVPKSLVWDNESAVGRWRGGRPQLTEAMNAFRGSLGIKVIQCRPGDPEAKGLVERANGYLETSFLPGRAFTSPSDFNAQLADWLDKANRRHHRRIECRPVDRLPADLNAMVELPPVPPQTGWRLSMRLPRDHYVRLDGNDYSVHPAAIGRRIEVTADLDQVTATCGGRTVAAHQRCWASHQTITAPEHDKAAGDFRRRHLVPATPATATPVQQRKLSDYDRLFGLTDEPTGGEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V0Q1</accession>
    <name>A0A1H5V0Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Osmoprotectant transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80853">
        <property type="protein sequence ID" value="SEF80853"/>
        <property type="gene ID" value="SAMN04489712_102115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="33"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF80853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="247" mass="26186" checksum="440E3416D62EF177" modified="2017-01-18" version="1">MSPLTAVLASEAEPLIRWDWIERNLGDDIAEALREHLILSFTPVLLGLVVALPLGIACARWRRVYPAVLAATSVLYAVPAIALFVVLVAFTGLTYSTVIIPLAAYTLSVLVPSVVDGLHSVPAHVRQAAVAMGFGPLRRLVRVELPLAIPVVMAGLRVATVSNISLVSVGSLIGIGGLGELFTTGLKRDFPTPIVVGIVAIIALALVSDMLLLLIQRLLTPWERAGSGGRKARRAQEKTLVTAGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V190</accession>
    <name>A0A1H5V190_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80930">
        <property type="protein sequence ID" value="SEF80930"/>
        <property type="gene ID" value="SAMN04489712_102118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF80930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="35796" checksum="1C50672679DFB253" modified="2017-01-18" version="1">MPQKRKRATIREVAQATGLSPAAVSYALRGIQTSEETQERVRAAAEELGYEAHPIARALASGRSGMVGLLCGSLEDYWQQSLAVGIGRALVGRDRYALILDAAGDPARELVLARRLGDQRVDGLIVQPLDPSAPLWAELAETLPVVSIGDALHGGRSQGEVVFDNRAGVTLALEHLRELGHRRIAVLTSTRASTPDRPADVYVNAEAERLGVEVTLVTAPQSWAEATEVALGVLAAPGRPTAVFCFSDSIAYGVYAATRELGLSVPGDVSVCGYDNHPMSELLTPPLTTVDWDIDGIVHSAVQVMVEAVDGTPRRRRIVRMPTLCVRRSTGPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V1M6</accession>
    <name>A0A1H5V1M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase specialized sigma subunit, sigma24 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81136">
        <property type="protein sequence ID" value="SEF81136"/>
        <property type="gene ID" value="SAMN04489712_102125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF81136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="41608" checksum="491BD7EF2C622A9B" modified="2017-01-18" version="1">MPGTPEALYDAHAARLHAYCWSLVGEDADAAVRDTFVAAMRHPPRGDAVLWLYALARSACLDRGAPDRPFVPGTHPDPLLRAAAGLRADHREVLVLSAGEWLDEPDIALVLGVATDTARQLLQAARTRLERAVLDRLMREPGSPYHSEIITAFEKGTLPRLLARRAPDRPPAALREQVLAACAAEIEQPLSTLAFPSPLVAIGPATTRPAASRRRSRGLGTVAGLAASAAAAVGLIAAWAGAKDGGERLTALNPSAGYGSESATAGPVTSPDLASSDPAGTAGTGPAGADPKTSASSPYGLTPPVPGVQPADPGTPAPDPDEASPTPDPSSPLPTPDPRTPTPPPSPEPDDPTSPAPDEGEGEDDKDKDEGGPLRLPIPTLPLPSGTSSQAPGPMPAPTANPSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V937</accession>
    <name>A0A1H5V937_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83730">
        <property type="protein sequence ID" value="SEF83730"/>
        <property type="gene ID" value="SAMN04489712_102217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF83730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="146" mass="16238" checksum="6305E1CFD85EDC5B" modified="2017-01-18" version="1">MPKDVQPRPCSIADTLEVVGERWSLLAVRELFHGVHRFDGIARNTGASRDILAARLRKLEAAGVIRRKLYSEHPPRYEYHLTQAGRELGDVLLALAKWGDRHLNADDPPVRWHHSCGELLDPVVVCATCGRPAREGAHSPVGRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VCY9</accession>
    <name>A0A1H5VCY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized conserved protein YjbJ, UPF0337 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85090">
        <property type="protein sequence ID" value="SEF85090"/>
        <property type="gene ID" value="SAMN04489712_102266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF85090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="7019" checksum="52C7CBCC2577772C" modified="2017-01-18" version="1">MSLLDKLKNKAQQVKGRGKEETGRRTGDPYLESEGRGDRAAGGMKQAGERVKDAAKDVRRGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VDP4</accession>
    <name>A0A1H5VDP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85196">
        <property type="protein sequence ID" value="SEF85196"/>
        <property type="gene ID" value="SAMN04489712_102270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="215"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF85196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="481" mass="50148" checksum="44E33AB5517650AC" modified="2017-01-18" version="1">MAGLPPAGPSGGHLEEGSSSRWRSRRDGPPTYHRDVLTRWMERIFDDQLAPARFVVLSVLALGDLRLLHRPEDPWDWALALGALAVCLAGCRAPLAAAVTLSALLVSGDLLGAHVGVPLKAMIAVSLFELALRTSGRRLAAGIGVTTVLLTLHALNAASAQVLPTLYRLSILAGLPLLFGAYVRLMRENARQARERVCEEERRRRSETLAARAAERTAIARELHDLVAHHVSSMVLRVGVARHVLTDVDPRMTEVLDDLHGSGAAALADLRRLVALLRDPAQVHDDPAVSLVEPAGLVEALEAALERGRQTGLTVSADVDPAIGGLDAVRGLTILRLTQEGMANVARHAGPAASARFSVRLDGDTVRLEIVDDGGRPDPAAAGVGATVRSGGHGLIGMTERAQLLGGRLAAGPVPGGRGWRLLAELPSGTAPSDGPVAAPGTDAVAGPAPQAPALATFSAPPPERPLGTLDRGGPLGGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VKS5</accession>
    <name>A0A1H5VKS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87820">
        <property type="protein sequence ID" value="SEF87820"/>
        <property type="gene ID" value="SAMN04489712_102357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF87820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="316" mass="34824" checksum="F77FC5A0B312BA13" modified="2017-01-18" version="1">MTATEAERTLFTGAGPQVDAVAAGRLAALVVDLDRDLADCAAAYADLYPDPPFEPSLFTKVAQAIGGQGPWHSAAQLRISNRTSAWIFALDWIMDHAAGSLAEIHDTVARCLAVGDGDDPAPGDRLGQFLAELRDVLAATPAWSRFGPVWREELRLMLEGMAREWEWKDAHARGEAGLPTYERYLDNADNFGSVWGNVAHWMHVGAPATLDHMEPLREVSRQAQKVLRLLNDLATWHRDRAWGDLNALMLGVDPQFVIAHITALTEHCHRMLEPLRDRCPQGAVFVARQLGYSTGYYGSGADYWGALGAERPRSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X389</accession>
    <name>A0A1H5X389_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06319">
        <property type="protein sequence ID" value="SEG06319"/>
        <property type="gene ID" value="SAMN04489712_10373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG06319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="216" mass="23332" checksum="6F4E4A6243BC0EF3" modified="2017-01-18" version="1">MSVDGYIDDTTPERLRLSSPADFDRVDGVRATCDAILVGANTIRRDDPKLLIRSPARQERRAARGLPRQLVKVTVTAGGDLDPGARFFTTGETPKLVYAGSRAAAGLAERLAGAAEVIDGGDPVDLRGMLADLARRGVRRLMVEGGGGMHTRFLTEGLADELQLVVAPFFVGDPSAPRFVHPGVFPQDPAHPMRLAEVTRIGDLALMRYLIKHPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X402</accession>
    <name>A0A1H5X402_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06097">
        <property type="protein sequence ID" value="SEG06097"/>
        <property type="gene ID" value="SAMN04489712_10366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG06097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="484" mass="54677" checksum="F7CF3DEB7200AE5E" modified="2017-01-18" version="1">MKSSYEVAIIGSGFGGLGMAIRLKQAGVHDLTVLEKAGDLGGTWRDNTYPGAACDIPSHLYSFSFEPKTDWARRYATQPEILDYLRHCARKYGVLPHIRFGTEVTEARFDSDAGIWRISTTGGELTARVLISACGQLNRPSLPDIPGRDAFAGISFHSARWDHSAELDGKRVAVVGTGASAIQFVPELAGRVERLYLFQRSAPYVIDKTDRAYTRLGRGLLKAVPGWYPLNRATLYALFEARALGFVKYPALMAPVVRRFQKNLHAHVLDPALREALTPDYPMGCKRILISDDYYPALTRPHVELVTEPIERVTAQGVRTRDGTERRVDTIVYGTGFRTGDFLAPMKVVGPDGRELNETWRDGASAHLGITVSGFPNLFLLYGPYTNLGHNSIIYMLESQIRYVLGCLQAMRRTGLRWIDVRPEVQEAFEARMRRRMRETVWEQGCHSWYMTEDGKVVNNWPGFTFTYRNATRRPDPRHFRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XFD9</accession>
    <name>A0A1H5XFD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_103220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10185">
        <property type="protein sequence ID" value="SEG10185"/>
        <property type="gene ID" value="SAMN04489712_103220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="30"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG10185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="281" mass="30213" checksum="86EC103CCD2C382D" modified="2017-01-18" version="1">MTSTSLVSPAEPVESTGAPARLRWALADGWTLTRRALAHWARRPEQVVMGLLFPVMLVLMFGYLFGGQMAVPGGGSYREFLMPGMFAMTMVFGVETTFAAVATDASRSITDRFRSLPMASSAVVAGRGAADMLHSVLALTVMAVTGLAVGWRWHEGAGRALAAAGLLLLLRFALLWLGVYLGLVARSPELLVAVQVLVWPIGFLSNAFVDPATMPGWLGAIAEWNPLSATIGATRELFGTPGWDGGSWAAEHAVPMAVLWPLLLAAVFFPLSVRRYRRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XFE1</accession>
    <name>A0A1H5XFE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10462">
        <property type="protein sequence ID" value="SEG10462"/>
        <property type="gene ID" value="SAMN04489712_103230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG10462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="377" mass="38473" checksum="C4EDB8AF181F4B3E" modified="2017-01-18" version="1">MPRHPSTSGELLRLIREEGVSTRAELGRLTGLSRPAVTLRVTELVAHGLVTERPGELSSGGRPPARLEFNAAGGAVLVANLGHRRGQAAVCDLAGGILVQSAPDLPTGREPAELAARLLDHWDELLDKAGLTRAAVRGVGLGRPGNAGAPGGPGVDGADLRPVVAERFPVPAYLDNDVNVAALGEYQARYRGRIDDLLFVKLSTGIGAGLIAGGRIQRGALGAAGEIGHIPVRDGGGTPCRCGNLDCVEAVAGGAALLARSGAADLTELAVRARGGDPEVVALVREAGRRIGEVIAAAVNLLNPAVVVLGGDLTGAYEPLIAGVREVVYQRATALATGRLRIEPSMLGDTAGLAGCAAMVLDRILSPAAVDESLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XPZ5</accession>
    <name>A0A1H5XPZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ca-activated chloride channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13829">
        <property type="protein sequence ID" value="SEG13829"/>
        <property type="gene ID" value="SAMN04489712_103356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="339"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG13829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="526" mass="56531" checksum="495975D7437D6E44" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XUN4</accession>
    <name>A0A1H5XUN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15372">
        <property type="protein sequence ID" value="SEG15372"/>
        <property type="gene ID" value="SAMN04489712_103415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG15372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="37968" checksum="1BB6912A98E12DCD" modified="2017-01-18" version="1">MDLTVVGTPGDRRVTLFEAACRAQGLRPPEVLAWRDVLAGREPSMTPGTLLRIDSPGGDAECDALLRGPGDPARVGDGARWYAAFTGALRRVAAAAGRAGAVPLNDPDEIAVMFDKRRCHARLAAAGVPVPPALDGPVLGYDDLRERMAVAGLRRVFVKPAHGSSASGVVALQVGAGRVKAVTSAVPVPGGGLRNALRVRSYETEHEVAALIDALAPDGLHVERWLPKAGLAGRTLDLRVVVVAGTPTHAVVRTSRSPMTNLHLGGARGDLRAVREAMGEDGWRRALRVCAQAARCFPGSLMVGVDLLIGVGWRRTAVGEVNAFGDLLPGLTGLPGSPGERLDTYTTQVRAVMSRYMGPCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y1I1</accession>
    <name>A0A1H5Y1I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent DNA helicase DinG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17460">
        <property type="protein sequence ID" value="SEG17460"/>
        <property type="gene ID" value="SAMN04489712_103497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="25"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="463"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG17460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="726" mass="76759" checksum="D693ABB3A7B5508E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YIQ3</accession>
    <name>A0A1H5YIQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23874">
        <property type="protein sequence ID" value="SEG23874"/>
        <property type="gene ID" value="SAMN04489712_10433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="22800" checksum="DC9C2BCD3B647E90" modified="2017-01-18" version="1">MAKYFDVHPDNPQPRALRQTVDLLRADGLIAYPTDSCFALGCRLGNREGIDRIKEIRHLDDRHHFTLVCKDFAQLGQFVQISNALFRSIKAATPGGYTFILPATKEVPRRLLHPKKKTVGVRIPDHVVVQALLAELGEPLLSSTLLLPGETEPLTQGWEIKERLDHVVDAVLDSGECGAVPTTVVDFSQGEAEILRRGTGDPSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YVD6</accession>
    <name>A0A1H5YVD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27954">
        <property type="protein sequence ID" value="SEG27954"/>
        <property type="gene ID" value="SAMN04489712_104202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG27954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="352" mass="38665" checksum="215A8F34A38CFB41" modified="2017-01-18" version="1">MASEDPNDALPPGEADAAAMFAEQFRAPAEERMGLRAGLGSEDFQALAAYSLHVCESGSKEEIRYALELLDLIPIPADRTGVREHAVRVLPGLCRLDQDTDILAAALPIYGRYMPDPPAVRTLRAMVGHPLPQVRAGAVEGLEYFADEGSSPSATLELVEWLVRALIEDPDAQVRRTAVRAFIGLEGWWGYEPGRFPELIPLVVTALGRAVRDDPDQRVRGEAAERLACLSDLEERHWPLVDAALRPYTEDGNVRVAGHSLARLASLGDPGALERLWTTLAAPDVHRLYLSAAKRALTSCPHPSAESLRRLREALRRLRELGWRDDASGDVPRLSPEEHAYYLDLLLDGLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXQ8</accession>
    <name>A0A1H5YXQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_104251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29069">
        <property type="protein sequence ID" value="SEG29069"/>
        <property type="gene ID" value="SAMN04489712_104251"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01272">
        <property type="entry name" value="ACUCPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="6">
        <location>
            <begin position="32"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG29069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="44814" checksum="B0A6AE5CF3EDDD34" modified="2017-01-18" version="1">MSSAAPSDRPGPCDLRVLWDDRLTSYDFGPTHPMNPVRVELTMALAREYGVLDHANVEVAAFETAGDVLLELIHDPAYIAAVRHAGATGLPEPRHGLGTPDNPVFLGMHEASALVTGASVAAAEAVWTGRCAHAANIAGGLHHAMRAAASGFCVYDDPAIAIAWLLEHGAERVAYVDVDVHHGDGVQTAFYNDPRVLTISLHETPRTLFPGTGFPQETGSGEARGTAVNVALPPGTGDAAWLRAFHSVVPPLLRAFKPQVLLTQHGCDSHTLDPLAHLMLTVDGQRTAYAALHRLAHETAGGRWIVTGGGGYELVQVVPRAWTHLLAEAAGRPLDPRLATPEPWREFAKRRTREVGSGGVMGEPPRQMTDAPQDRAGGADTVEVHTWGSGFDPANPVDQAIRATRRAVFPEHGLDPLTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZQ8</accession>
    <name>A0A1H5YZQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain-containing protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29753">
        <property type="protein sequence ID" value="SEG29753"/>
        <property type="gene ID" value="SAMN04489712_104280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG29753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7437" checksum="395B00B0AFBFA082" modified="2017-01-18" version="1">MESTSERLLTPGEVAALFRVDPKTVTRWAAAGRISSIRTPGGHRRFRESEVHALLRGEEPLAEHSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z7F9</accession>
    <name>A0A1H5Z7F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32241">
        <property type="protein sequence ID" value="SEG32241"/>
        <property type="gene ID" value="SAMN04489712_104400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG32241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="523" mass="54881" checksum="080C860BCC533186" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z7G5</accession>
    <name>A0A1H5Z7G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31547">
        <property type="protein sequence ID" value="SEG31547"/>
        <property type="gene ID" value="SAMN04489712_104363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG31547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="9739" checksum="2E7BA7656889A4EC" modified="2017-01-18" version="1">MWRAWLFVFLLAACLVGIMLGMLAQLTGSATLKRTAEVLVLISAAAFLPLLVEHALEKPLMWAVVVLDAGMVVGGVIAFTRELSTRRTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z834</accession>
    <name>A0A1H5Z834_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine protein phosphatase PrpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32200">
        <property type="protein sequence ID" value="SEG32200"/>
        <property type="gene ID" value="SAMN04489712_104398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG32200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="27113" checksum="66439EBBC5B0545C" modified="2017-01-18" version="1">MDIRYASEATPGRPNEDCVVAGDGWVVLLDGATQRPDVDSGCVHGPRWLVARLAGELARLLTAEAAAPLADLLAEAIGGARRAHADGCDLTNPDSPSTTAAVVRRRGERLDWLVLADSPVVIDLDGRIEVVLDDRTARLPSYTAEAVRRLRNAPGGFWVAGARPEAAYEAVTGSATLSDVRRLAVLSDGAARLVERFGLLDWRGLLDVLDREGPAELIRRTRLAELAETAAERAGRRGKRHDDATAALVRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZ10</accession>
    <name>A0A1H5ZZ10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41753">
        <property type="protein sequence ID" value="SEG41753"/>
        <property type="gene ID" value="SAMN04489712_10597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG41753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="214" mass="22957" checksum="66B015E9F797FC0F" modified="2017-01-18" version="1">MRVEPTCPRCDRPLHGPGAGSGEWTCPVHGAVLPRQPARPPSPEGLAAALHDARVPLWMPWPLPPGWLVTGFLNVGDERSGARACAVAVSGPALLQGTADMLLIAEEPGVGLGAWYAGLEEVDPGRRIGDGPPHAKVEIQATGTRPHQLPLWALTGGRDRAVYIGEAMGNWLWIVLWPADAGVLMVDELHLIDLREPGMDLDLPYGVFCSRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AC50</accession>
    <name>A0A1H6AC50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45627">
        <property type="protein sequence ID" value="SEG45627"/>
        <property type="gene ID" value="SAMN04489712_105314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG45627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="18709" checksum="1D12DBC68208B85E" modified="2017-01-18" version="1">MTVALVPTVTASEQAVAAIPAQPARQPAGISAASSAPRQHVHSSAPQRRGHPSVPLRHAYRQRLARADRNRLLARKIVRRHGGGPRQYRCLDRLWTSESGWNHRAHNPDSGAYGIPQALPGDKMARSGDDWRTNPRTQIRWGLLYIDIRYGTPCRAWAYFRDNGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXR2</accession>
    <name>A0A1H6AXR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53341">
        <property type="protein sequence ID" value="SEG53341"/>
        <property type="gene ID" value="SAMN04489712_10687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="52"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="421"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG53341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="515" mass="55373" checksum="D0AEA26725FA8622" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYS0</accession>
    <name>A0A1H6AYS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate permease, MFS superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53450">
        <property type="protein sequence ID" value="SEG53450"/>
        <property type="gene ID" value="SAMN04489712_10693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="12"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG53450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="492" mass="50298" checksum="576C7425CF4A8EA1" modified="2017-01-18" version="1">MTAKMTAEVWRRDLAASLVVFLVALPLCVGVAVASGVPAELGLVTGIVGGLVAGLLPGSSLQVSGPAAGLTVLVYDAVQQHGLSTLGVLVLAAGLLQLVLGALRMGRWFRAISVAVVEGMLAGIGLTIIAGQLYAMADADAPGSGLGKIFGLPGLAADGFGSAATLTAVAVGAATIAVLVVWPRLPARVRVVPAPLAAVALATAVVAVFDLPAARLEIHGLLAAIQPPGAGELARLAELSVIGTVVAFALISSAESLFSAAAVDRMHDGPRTDYDKELMAQGAGNAVCGALGALPMTAVIVRSSANVNAGARTKASRVLHGVWLLLFAALFPAALGIIPLAALAGVLVHTGWKLVPFGRLAPLWREHRGEAIVLVTTAVAVVALNLFEGVLLGLLLAVLKTAWETSHVTVRVDDDGTGPIRATLGGNATFLRLPKILDALEALPRDRHIELDLSGLRHLDHACRTALTNWADKHNAREGEEPPAIAIVGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3X1</accession>
    <name>A0A1H6B3X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress responsive A/B Barrel Domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54836">
        <property type="protein sequence ID" value="SEG54836"/>
        <property type="gene ID" value="SAMN04489712_106183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG54836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="93" mass="10295" checksum="88AAB4410DA2579A" modified="2017-01-18" version="1">MLTHVVLMKFTDPADAPEAKERLEGLVGTVEQITSMTVGLDLLHTDVSYDLCMTTTHDSVEELRAYQGHPAHLEVAGWLRPRLAARAVVDHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B9C0</accession>
    <name>A0A1H6B9C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_106335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56766">
        <property type="protein sequence ID" value="SEG56766"/>
        <property type="gene ID" value="SAMN04489712_106335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="31"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG56766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="523" mass="54282" checksum="BD9422B0D5096D02" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BE65</accession>
    <name>A0A1H6BE65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59091">
        <property type="protein sequence ID" value="SEG59091"/>
        <property type="gene ID" value="SAMN04489712_10746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="55"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG59091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="37585" checksum="DE7C8340CC8CD1D4" modified="2017-01-18" version="1">MTPTAPPVLPTTPQIIGGCRDRFRPRRPTPPPGPRARPPAPRGHLPRGRCPVNELKVTDLTVKFAGITALDHVGFTVEPGSIHAVIGPNGAGKSTCFNVLSGVYRATSGSVRFGDAELTRMAPHQIAALGVARTFQNIALSKFQSVEDNVMLGRHRLTRAGFLGAGLRLPSARRENARHRARVRDIARFVGVAEYLEAPVGMLPYGVQKRVELARALAMEPDLLLLDEPVAGMNGGERRAMAEVIMAARADLGISVLLVEHDMGMVMRLADQVTVLDFGRRIAAGPPERVQRDPAVIRAYLGEQAADEQTADEQAADEQATDEQTADGDPGTIRDRRDGRAADERENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJS9</accession>
    <name>A0A1H6BJS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_107148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60675">
        <property type="protein sequence ID" value="SEG60675"/>
        <property type="gene ID" value="SAMN04489712_107148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG60675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="244" mass="25911" checksum="5E30E513BC1205A9" modified="2017-01-18" version="1">MSAPVFLAAPGSLGADRVVLDGPEGRHAVTVRRLRPGERVDLTDGAGLLAECVVAEVAGKERLVLDVLSRQRQEPPSPRLVVVQALPKGERGELAVETMTEAGVDEIVPWQAARCVTRWRPDRRDKALGRWRSAAREAAKQSRRSRLPEVPDLATTEQVAARLAAAARAVVLHEAATVPLRTVDLPADDEIVVVVGPEGGITDEELERFTAAGAVAVRLGPTVLRTSTAGVAAAAVLLSATGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKT4</accession>
    <name>A0A1H6BKT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60816">
        <property type="protein sequence ID" value="SEG60816"/>
        <property type="gene ID" value="SAMN04489712_107159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG60816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="587" mass="64391" checksum="0BBF197008FB29F3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BL49</accession>
    <name>A0A1H6BL49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60926">
        <property type="protein sequence ID" value="SEG60926"/>
        <property type="gene ID" value="SAMN04489712_107168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021994">
        <property type="entry name" value="DUF3592"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12158">
        <property type="entry name" value="DUF3592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="20336" checksum="8126E94C69A6931C" modified="2017-01-18" version="1">MSRWGLWMSALERRHQARFRATRRMTGRSRRAVPIPGGLTTFTVALGVLLGVAASFEIQAVWGGAEASGAVVKTWADAKGTGYADVVFTTSQGRRVRASVKEDGWAEMPKAGERVRVWYQPARPVDSAVDARRPGLGVGWQEHAVIWLITVGVFGTMAYRYRTKDAGARDVVLRRSPKDAPPLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BP60</accession>
    <name>A0A1H6BP60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="12" type="ORF">SAMN04489712_107301</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62509">
        <property type="protein sequence ID" value="SEG62509"/>
        <property type="gene ID" value="SAMN04489712_107301"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="9">
        <location>
            <begin position="28"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="10">
        <location>
            <begin position="178"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="11">
        <location>
            <begin position="300"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG62509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="422" mass="44232" checksum="27CD32907476E7D1" modified="2017-01-18" version="1">MGSMMAASSQTSSSASSGGSGASGRRDVVLLGSTGSIGTQALDVIRRNPDRFRVTGLAAGGGRVDLLAAQALEFRPEVVAVARASAAQDLQLAFYAEAQRHGYSSGDYQIPKIVAGPEAVAEVAAWPCDLVLNGVTGALGLASTLAALDAGRTLALANKESLIVGGPLVKERATPGQIVPVDSEHSALAQCLPGWRYGEDAATRRVRRLVLTASGGPFRGRTRAELAGVTPEQALAHPTWDMGPVVTINSATLVNKGLEVIEAHLLFDLPFDRIEVMVHPQSVIHSMVEFTDGSTIAQASPPDMRLPIALSLTWPDRLPEAAPALDWTKAHTWELLPLDDEAFPAVALARHVGGLGGTAPAVYNAANEECVEAFRAGRLPFTGIVDTVARVVNEHEVATAGVTLDDVLAADAWARARARELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUH5</accession>
    <name>A0A1H6BUH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64358">
        <property type="protein sequence ID" value="SEG64358"/>
        <property type="gene ID" value="SAMN04489712_10817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="301" mass="29439" checksum="F36EE5E9BA898A33" modified="2017-01-18" version="1">MRGLILGGALGAVAARAAYVALTRRPPGMNGRDGREVWGRTNHRGEPVTLLEGPAFVAGAVAAGLLAPGVPGRMRAAALLAATGSGVLGGYDDLAGSASSRGFKGHLGALARGEVTSGAIKILGIGATGLAAAALAGSPAPTRAGRTFDTLVNGALVAGSANLMNLFDLRPGRAIKVGLLAGAPLAATGPARAAVVAAPLGAAVALLPEDLGERAMLGDAGANALGALLGLAATGLGRGPRLAVLAGLAGLNAASEFVSFTKVIQRTPALHWIDMLGRRPAHTPAAPPATPQAADEVADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C174</accession>
    <name>A0A1H6C174_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66126">
        <property type="protein sequence ID" value="SEG66126"/>
        <property type="gene ID" value="SAMN04489712_108166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG66126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="452" mass="46734" checksum="5F2D7B24CF4425E3" modified="2017-01-18" version="1">MTEVLVIGAGLAGLAAAVSAAESGARVTLCEKRSEIGGSTVLSAGLSAFAGTEEQAAAGIADSTELLRHDLLETGLHRNDPALVDAYCAHQLDTYRWLRGLGVEYGKVHAASGQSVPRSHPTDTRVLVRTLLERALSRGAVFLPDTRAHRLIVEDGAVRGVLTEEGERLRADAVVLASGGFSRNPELLTRFAPQMERALRGGAAGSTGDGLLMAWKAGAGVIDTPYVKGTFGIHPDPDGAEGGTGVLAIYKGAIAVNRNGRRFVDESLPYKAVGDACLAQPDGIAFQVFDAQVMDRADPSVPIYDFAARVGNGLLLRARTLDELAGLIGVPADALRETVAAYNAAIAGRAPDEQGRTTLSGGVGTPVPITTAPFYAHPSTAVVLATYCGLTIDPSMRVLDVFGEVIDGLYAAGELVGGLHGAGYVTGTSIGKAAIFGRVAGLAASGAREERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C6I0</accession>
    <name>A0A1H6C6I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68579">
        <property type="protein sequence ID" value="SEG68579"/>
        <property type="gene ID" value="SAMN04489712_1093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG68579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="244" mass="26751" checksum="79AB35D7270833FE" modified="2017-01-18" version="1">MSPPLRADARRNRERVLRAAGEAFAEKGGLIPLDEIARRAGVGAGTVYRHFPTKEALFREVVSVRLHAIVAEARGLLTAPDPGAAFYTFFTWVVEQAMFNHALCDALADGAGMEQFRCEDTDAAFTRAVDALLQRAQQAGAVRSDIDVVEVRALMSGCLAMERSHRPSVPSGRLTALTTEVLRPPTTVTKHTRRNETDDESRRCDVCGTPLAPSPTGRPARYCSPACRQKAHRRRRAATTPERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCG3</accession>
    <name>A0A1H6CCG3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_109187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70644">
        <property type="protein sequence ID" value="SEG70644"/>
        <property type="gene ID" value="SAMN04489712_109187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG70644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="475" mass="52203" checksum="3DCFA2D860FD2B87" modified="2017-01-18" version="1">MRVEAEKPLAGRYRLLSVIGKGGMGTVWRAYDELLDRDVAIKEAVLPEGLTSSERCAMCRRIVAEARATAALRHPGVVTVYDVLNEDGRPWIVMELLRARSLREVLARDGPLDSARAAEIGRAVLAVLNTAHAKGILHRDVKPSNVMLAEDGRILLTDFGLAVHMLNGHTVVDTMVSGIQGSPAYLSPEQILGMPGGTASDLWSLGVTLYAAVEGGSPFRRSHALATMVAVLIGEYAPPWNAGPPMRALIEGLLRQDPSTRLSAAEVAALLDLAADRPDDTWRSRRATWWENGRTSMFRRSRITALVGVAILAATVIVIGAWTARLRPGGTMAALSAQDRGTHTAAYREADGYSVEIPSGWVRERRRDGVHWNDPLTDRHLRISPVQGDALAGLQQAERDAIAANAYPGYRRIRLEATPDVAKDAAEWEFTTHRFRYLRSRMAGYEFLFITPEDRWTPGQRAFEAILRTFRTSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CI83</accession>
    <name>A0A1H6CI83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">8-oxo-dGTP diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72664">
        <property type="protein sequence ID" value="SEG72664"/>
        <property type="gene ID" value="SAMN04489712_11024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG72664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="33531" checksum="2D861759A46CA96C" modified="2017-01-18" version="1">MAETVPEGALIRAAGVVLWRGGPDGPRVALVHRPKYDDWSFPKGKLDKGEHVLAAALREAEEETGLTVRLGRRLPTTTYMKSGRPKRVDYWSATAIGAGRPFVPNHEVDRLEWLPVDDAARLLTYERDVDLLHEFAAGPAVTRPVVILRHASAGDKRHWRDDDALRPLDEHGRCEARLLADLLGAFGPLRPVSSATARCVETLLPYTLANGAEATTAPAFTIGRPPEQARRKLDELIDEGVPFLVCTHGEIVADLVTELCRRLGEKAPDDPSLRKGSFWVAHLSTDPHGHPTGIAALERHSTHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKG9</accession>
    <name>A0A1H6CKG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gas vesicle protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72916">
        <property type="protein sequence ID" value="SEG72916"/>
        <property type="gene ID" value="SAMN04489712_11050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007805">
        <property type="entry name" value="Gas-vesicle_GvpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40137">
        <property type="entry name" value="PTHR40137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05121">
        <property type="entry name" value="GvpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG72916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="23440" checksum="E214ED281DFC63E4" modified="2017-01-18" version="1">MNDPARDDLRPTAPTPPEPNPARPDDQPAKAGPEDIRHGVVRAGDRRVEADPEDVRYGVARAGDRRVEADFEDVRYGVARGDDWYAEDGFEGVRYGVGRGGDRYVEGEAGEARRGFSRAGGRRIETDPEHVQRDLTKLVLTVVELVRQLVERQCIRRFERGDLTDEQVEAIGTTLMRLEEAMEELCDRFGLSPSDLNLDLGPLGTLLPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM36</accession>
    <name>A0A1H6CM36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74022">
        <property type="protein sequence ID" value="SEG74022"/>
        <property type="gene ID" value="SAMN04489712_110181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="79" mass="8684" checksum="3D19DF79CFB599C0" modified="2017-01-18" version="1">MAYALMQEAQVMTNPFEDPNADYLVLVNSEGQHSLWPVFAPVPAGWSTAFGPAGRDACLEHVRTHWTDLRPRSLAEASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMT0</accession>
    <name>A0A1H6CMT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, ENTS family, enterobactin (Siderophore) exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_110154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73786">
        <property type="protein sequence ID" value="SEG73786"/>
        <property type="gene ID" value="SAMN04489712_110154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG73786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="414" mass="41681" checksum="8DFB7D4A67009488" modified="2017-01-18" version="1">MAHRLAMDISPLRTSRPFRNVFVARTVSVFGIGMLMVALPVQVHEMTGSTVHVGAVAAASGFALLAGFLWGGVLADRHDRRRLMLRARTAAAVGFALLTVNAFLPSPSLGALYVLAAWDGLATGVSVTALLAATPALVGPDKLVAAGALNALTVRLGSMLSPALGGLVVSAFGVGWNYAAATAGTAGTLGLLTSLPSLKPAAETAETAGNPLKAIGSGLRFVAGHRIVGSLMLLGLLFMVAGGIPVLMPAFATGQLGGGPTTVGLLYAAPACGAVLASVTSGWTSGLRTPGRALLIASVAGFVTLACLGLARHPALAVAILFGYGFVASIEEILRYGLIQTHTPDGYLGRVNALWSAQETGGEAVGSLGAGALGRYLSPGDAIVVYGTVSAALSLVLAITLTGLRTATLKPEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNE1</accession>
    <name>A0A1H6CNE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74539">
        <property type="protein sequence ID" value="SEG74539"/>
        <property type="gene ID" value="SAMN04489712_110239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG74539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="179" mass="19563" checksum="FBDA638E5872F228" modified="2017-01-18" version="1">MARDLSSPERPLLLAGVMIAALSVLVGCGDGETVVTATRTPTPTPVSQEEAVKHAYAAALENGKRALLGPADQVRVVLRESHTGEELDQLVRDVIKTQEEHRAPTGRLVPHVGKVELRGTEAIVYDCLDLGSYGFKDTRTGEQLPRRGPVRAGYKVWMRQGGDGRWRISRLRGHEESCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTV4</accession>
    <name>A0A1H6CTV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized iron-regulated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76113">
        <property type="protein sequence ID" value="SEG76113"/>
        <property type="gene ID" value="SAMN04489712_111124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="463" mass="49653" checksum="B8992D8D80A6AF33" modified="2017-01-18" version="1">MSLQTSVPAPPEPTQAPRSVRSGLAALALRLHFYAGMLIAPFLLVAATTGFLYACSWQAEKIIYADQLRVPAAGERLPVERQVQIAKVARPDGTVLGVRPSVETGQTTRVLMDVAGLGTSEKLAVYVDPYRGTVRGELTVYGGSEALPVRAWLSQTHRHLHLGDPGRLYSEMAASWLWVVVLGGLVLWISRRRTRRRELAFPDLKARGRRRTLSLHGTVGLWAAAGLLFLSATGLTWSQYAGARVNVLQEKLNGVTPTLSGTAAAGHHGSGGTGHDHGHDASPSQADVDRILAAAGLAGPVEVTYPKAADEAFVVQQVDRSWPLRQDSKAIDPSSAQVIDTLAFADYPFLAKLTAIGISAHMGSLFGPVNQLLLAALAAGLITLIVLGYLMWWRRGRHGFGRPIPRGAWRSAPPWLLVPLGALALGAAWLVPLFGYTLLGFLVVDAVIGALIRRRTRTGTVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYT2</accession>
    <name>A0A1H6CYT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_1126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG77958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77958">
        <property type="protein sequence ID" value="SEG77958"/>
        <property type="gene ID" value="SAMN04489712_1126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG77958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="384" mass="41130" checksum="EFF5E21B1B8348A4" modified="2017-01-18" version="1">MDVLRVDDRLTDDERMVRDTVRAVVAEKILPNVAGWFEAGTFPARELGPELGKLGLLGMHLQGYGCAGMSAVAYGVACRELEAGDSGLRSFVSVQGSLAMTAIHKYGSEEHKREWLPRMAAGEALGCFGLTEPDRGSDPGDMRTHARRDGSDWVLNGAKMWITNGSVADVAVVWARTDEGIRGFLVPAGTPGFTASDIHRKLSLRASVTSELVLDDVRLPGDAVLPGVTGLKGPLGCLSEARYGILWGAVGAGRACYEAAVEYAKTREQFGRPIGSFQLTQEKLAWMEIALGQAGLTALHVGRLKDAGEVTPQQVSFGKLANVRAALDVARQARTILGANGITLEYPVIRHMNNLESVLTYEGTQEIHTLVLGQAITGISAYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZ64</accession>
    <name>A0A1H6CZ64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78107">
        <property type="protein sequence ID" value="SEG78107"/>
        <property type="gene ID" value="SAMN04489712_11229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="15588" checksum="EF709A6A1A598E6E" modified="2017-01-18" version="1">MKKFAENASLTAVEVQRSRLSGVRTVVNVIFAFTDRTTDKRPWRHGPQVGITPLTWDFPCIPNGKRSTRLHNHGADRVPVHRVMARVFMAVARAARWHADRTRSGAVWAGTDSLPAVMHDQLTMAVRADRGRLTLDPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0G3</accession>
    <name>A0A1H6D0G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein YecE, DUF72 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78285">
        <property type="protein sequence ID" value="SEG78285"/>
        <property type="gene ID" value="SAMN04489712_11257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="33992" checksum="9C2D13A3AEB2DAEF" modified="2017-01-18" version="1">MGKILVGTASWTDKTLLASGWYPPEAKTAEDRLRFYASRFRLVEVDATYYSPPAERTVALWRDRTPEDFTFNVKAFSLLTGHPTRPGALYRDLRDRVPNKRNLYPQDVPPDVVEEVWQRFLGALRPLHEAGRLGVLLFQFPGWFPFGERNRRYILQVKERCAPMRICVEFRNATWMSEENRAATLGFLAEHDLPYVSVDMPQGHPTSIPPVLAATSDLAVVRFHGHSERWNSGDVRERFAYLYSEEEMRSWAARIKDLTERAETTHLIFNNCCADHSQQNAARLASLLGAERHATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D291</accession>
    <name>A0A1H6D291_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79174">
        <property type="protein sequence ID" value="SEG79174"/>
        <property type="gene ID" value="SAMN04489712_112178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG79174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="42161" checksum="F3E0D561EB9E0E7A" modified="2017-01-18" version="1">MSNEAEILPNLLREEEEFEIVMRGYNRRQVEDRLHRLKSDYQNQIRDLEARLARALDDVERTRREMAEVREARKPTGDDLSDRLRQIINLAEDEARDKVAEAESKGAQIRKDAEHESRRIIEEAREAAAKNVAEAQDKAGQVLGTAKKESEAVLTAAKQEAEQTVTSARLEAERTLTAAERRAGVINDDATRRLTQLTRNHTQALQRLTEISETLNTLLRAENEAGPLEKMVDDAVRQAAPAARKPTAPAKPAAPAAAKPATAAPAASPATATSPVASPATGPAAAKPASAPAAPAAKPAVPVSAKPAPAPKHAVSPTPATPAPAKAAPEPAGAADSVRRAEPVRAAEPTGPADRPVAPAAPAVPAPAKAADDRPGLDKPAVAPVRPVPPQAPPPGTDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3V9</accession>
    <name>A0A1H6D3V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80049">
        <property type="protein sequence ID" value="SEG80049"/>
        <property type="gene ID" value="SAMN04489712_1135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="547" mass="59383" checksum="4686152D5C9C321A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D418</accession>
    <name>A0A1H6D418_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor type A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80040">
        <property type="protein sequence ID" value="SEG80040"/>
        <property type="gene ID" value="SAMN04489712_1132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="401"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="606" mass="64940" checksum="E769D773F022D8D2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7K4</accession>
    <name>A0A1H6D7K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80833">
        <property type="protein sequence ID" value="SEG80833"/>
        <property type="gene ID" value="SAMN04489712_113160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295613" evidence="1">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="24165" checksum="ED72A9EDBBB6E1D3" modified="2017-01-18" version="1">MLLLPVAVIGLTLRQRMPAAAASVTLPVPPPPVIGASRPHGHPVVPDPFTGSLLALGGPGAADLARLITLSALEGPGDDRLVVLPRADAAALFGLDEDELLDESPDQLFLPGTLDAALAFLETELRIRDDSEATGGEPKLLLVADCEQEAGRIAGLFARHPQGLSAVVLGGWPGEQAAVDENGLVSAPPAVAGLLPKQASAMSRAEARHRLDLLTEKCQGKSTRPKRRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8U9</accession>
    <name>A0A1H6D8U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_113176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80916">
        <property type="protein sequence ID" value="SEG80916"/>
        <property type="gene ID" value="SAMN04489712_113176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="27"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="221"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG80916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="45133" checksum="F715A1B54478DD93" modified="2017-01-18" version="1">MPSSLNIALVTMADLATDTAGTDVHTIHVLELARTLGRQGHRVTVYARRTAEDARPRIRLGAGATLEQLPAGPARPLDEARTLPHVKAFTEELSRRLAQPRQRPDLVHAHGWLGGLAAYAAVQDTDIPLVQSFHGLGVVESRRPGGRRTVHPARVRIERALGRGVTQVLAGCDNEADELVRMGVARPRITVVPYGVDGERFRQTGPAMPRGRRPRLVMVCGDLENGGVATAIRALVHVPDAELVVAGGPAREELENDPVVHRLRTLAKELDVADRALFLGRLPRKDVPKLLRTARLALCLAPHQPSGMTPLEAMACGVPVVTVPSGASADSVLDHVTGLHVPAGQPVALGRALRRLLAEETTLSAWAIAAADRAHSRYGWERIAAETARAYARLLPEPEPEPAALAEARREEEEPVGAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8X4</accession>
    <name>A0A1H6D8X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81780">
        <property type="protein sequence ID" value="SEG81780"/>
        <property type="gene ID" value="SAMN04489712_114141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="131"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="245" mass="26584" checksum="1EE03C4CE07AC17B" modified="2017-01-18" version="1">MATRLVQIHMKAQDDAALGRFWAQALGWGISSEEPGVTNLEPVDFVYPDPAAVCIDIVADPAPKTVKNRVHIDLATTSADHQADLVARLKDLGATPTDVGQGDVPWTVLADPEGNEFCVLEPRSIHRDTGPIAVVVVDCADPRAMARFWGEVMDWTLHEVTDEHAVLRSAKGVGPYLEFLRTPGVKTVRNRVHLDLRPYPGDDQAAEAARLRALGATDIDVGQGDVPWTVLADPEGNEFCVLTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9Q0</accession>
    <name>A0A1H6D9Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_114172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81918">
        <property type="protein sequence ID" value="SEG81918"/>
        <property type="gene ID" value="SAMN04489712_114172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="173"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG81918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="30918" checksum="F5EE9B62BEE901AC" modified="2017-01-18" version="1">MTGFAQPAASPPPAANARLVTLRGRSGVAAGSYRYEGDAVDLSWHRHDLHQLEYAFEGIVEVETAVARYRLPSRQAVWIPAGLAHKSGFVKARTVSVFFDPVLVRDTAGRARVLPVEPVFREMIIYAARWPIGRPASDQAADSYFEALAHLVVEALDQERPFYLPTSTDPLVTAAMRYTDAHLDEVSLTDVCRAIAVSERTLRRRFHTATGMAWRQYLLHSRLLHAMTLLSHGDRTVLGVATAVGFDSASAFSRAFQAYTGQTPTAFRQERRRPPRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DA80</accession>
    <name>A0A1H6DA80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81436">
        <property type="protein sequence ID" value="SEG81436"/>
        <property type="gene ID" value="SAMN04489712_11456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="108"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="324" mass="34160" checksum="FD4676570FD9A931" modified="2017-01-18" version="1">MLLALVSTAGCSLQTLGAPKGGMTLYAVFDDVQNLVVGHGVQMYDVRVGSVTGIRLRGYRVRVTLSLVDGTRVPAGTGATIARTSLLGENYVRLTPPPGSAPRTAPLLAAGSEITRTGVQPDLERITERVGPVLAALGGENLNEIIDGLASGLGGTGPRLHRIIERAAEISAGYAAAGEDLREVLDGMGRLSEDLAADSAALDRLPGSLLEMTERVDKDRAELKQALTGLTELAESAGSVIGERHGARLRKLLLRLDAVLGAMIRGKEDLKAATGAVLNKLLKTPRITHEGQALAYAWIGGFLPGRTTPRRDFGQQLERLLAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCB3</accession>
    <name>A0A1H6DCB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82453">
        <property type="protein sequence ID" value="SEG82453"/>
        <property type="gene ID" value="SAMN04489712_11528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="75" mass="7839" checksum="1CFDEAF72AFB196F" modified="2017-01-18" version="1">MGRGLWTPKSQAAGERPGGRPRMAARGRVPVPAGTSFAGGYLLGLDLECDLVLRFDLVLPSLSGSHSYPGVPCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHH9</accession>
    <name>A0A1H6DHH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbpA</name>
        <name evidence="3" type="ORF">SAMN04489712_11792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84917">
        <property type="protein sequence ID" value="SEG84917"/>
        <property type="gene ID" value="SAMN04489712_11792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="114" mass="12984" checksum="A9D4174A3AFF680B" modified="2017-01-18" version="1">MAERALRGTRLGATSYENDRNTDLAPRQEVDYNCSKGHRFTVTLAAEAEVPMTWECRNCGATALRVDGELPQPKQGKAPRTHWDMLMERRTIEDLEEVLAERLAILRAQRKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJT2</accession>
    <name>A0A1H6DJT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85444">
        <property type="protein sequence ID" value="SEG85444"/>
        <property type="gene ID" value="SAMN04489712_1185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="81"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG85444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="413" mass="43548" checksum="8B1FDA35277A0A24" modified="2017-01-18" version="1">MALDAADLGPATSLTCRECGESYDLGPRYACEQCFGPLEIAYDFTGVTRASIEAGPRNIWRYRGLLPVPTNVQDTPNTEPGFTRLVRADHLAESLGMQRLWVKDDSGNPTHSFKDRVVAVALAAARELGFKVLACPSTGNLANAVAAAAARAGIRSAVFVPSNLEQQKIVTTAVYGGTFVTVRGNYDDVNRLASEIAGEQDDWAFVNVNVRPYYAEGSKTLGYEIAEQLGWRLPDQIVVPVASGSQLTKIDKAFGELIKLGLVEDKPYRVFGAQATGCSPVAAAFKAGHEVVRPVKPDTIAKSLAIGNPADGPYVLDVVRRTGGAVEDVTDAEVVEGIRLLAGTEGIFGETAGGVTVACLRKLVSSGALDPDAETVIINSGDGLKTLDAVAPVARPSAEIAPSLEDFRASGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLK3</accession>
    <name>A0A1H6DLK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85465">
        <property type="protein sequence ID" value="SEG85465"/>
        <property type="gene ID" value="SAMN04489712_11810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG85465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="687" mass="70725" checksum="CF6C70C29606E603" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLS2</accession>
    <name>A0A1H6DLS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Butyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86212">
        <property type="protein sequence ID" value="SEG86212"/>
        <property type="gene ID" value="SAMN04489712_11921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG86212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="401" mass="43952" checksum="8CC222EF328A6A97" modified="2017-01-18" version="1">MTTTFEPQPTEVSELREIARQVAEKRYAPYVEQWDRDRTVITHDERRYLGSLGWLGIALPEKYGGAGGTFAEALTVVEELAKVWPPAAFQVFEANVGPAQHLARLGTEEQKQRFLPGVISGDNAMAIGISEPDAGSAATDMVTRAEIRGDTVVVRGLKRWISNGGDADRYLVYCRMNDIPGAKGIGAVIVEADRKGVSFGARERLMGFRGLPSADVILDDVEIPVENIVARPPDGFRDLFSMFSIERLGNTTMSLALGQAALDKTIAYVQEREQFGRPIAEFQAVQVSLADMLLEVESARLLRDRAVAGLDAGNPSTLHVSLAKCAANEMAKRVTDMAMMLHGANGYTEEYGLERMHRDAHGWALAGGTPNIQRTRIASELLKRSFDQRPARKAAVDHQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMI4</accession>
    <name>A0A1H6DMI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_119122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86597">
        <property type="protein sequence ID" value="SEG86597"/>
        <property type="gene ID" value="SAMN04489712_119122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="3"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="401" mass="43333" checksum="F1DCD3A8847F4622" modified="2017-01-18" version="1">MTSLFDGFDLRGLCLPNRVVMAPMTRARALTGVPDDMTTRYYAQRADAGLIVSEGSPVSKEGTGYAFTPGLYTDEQVAGWRSVTDAVRAQKGRMFAQLWHVGWASHVSLQENGKVPVSSTANAVGTVAFAYRPDGSTGMLPATPPRALGADEVARVVADFAAAAANADAAGFHGIELQAANGYLFEQFLNSRVNDRMDRYGATTVADRIRFTLEVVDAVADRIGAHRVGIRLSPYSTINFMPADDKTDETYRALGDELASRGIAYIHVSDNSDHRSEIGRAAGEELSAFLREWRPVLGDTALVLAGRQSLEKATRLIGEGTIDLAAFGRPFISNPDLVERLREGIPLAKPDRATYYTGGVRGYVDYPAAGRPASPGEGRERRAVRVVPARDQQGRPERGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNU8</accession>
    <name>A0A1H6DNU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kef-type K+ transport system, membrane component KefB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86884">
        <property type="protein sequence ID" value="SEG86884"/>
        <property type="gene ID" value="SAMN04489712_12026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="10"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG86884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="561" mass="59443" checksum="1CDEFA934864B6F6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPM5</accession>
    <name>A0A1H6DPM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_120112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87327">
        <property type="protein sequence ID" value="SEG87327"/>
        <property type="gene ID" value="SAMN04489712_120112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Toprim_N" evidence="4">
        <location>
            <begin position="236"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG87327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="563" mass="59609" checksum="F2887F30F6086C54" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPW8</accession>
    <name>A0A1H6DPW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_120116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87349">
        <property type="protein sequence ID" value="SEG87349"/>
        <property type="gene ID" value="SAMN04489712_120116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="301" mass="30900" checksum="F11222C36A8510B1" modified="2017-01-18" version="1">MICAGRVVIVTGAGRGLGRAHALEFARQGAKVVVNDLGVGRDGGGPGDEGPAHEVVREIRALGGEAVADGHDVATGEGAAALVATATETFGGLDVLVNNAGFLRDRMLVNLGEDEWDAVVRVHLKGHFLPLKHAGAYWRARAKAGEPVDARIINTSSGAGLLGSVGQGNYSAAKAGIVGLTLVAAAELGRYGVSVNAIAPAARTRMTEEVFAETMAAPEPGAFDAMAPENVSPLVVWLGSSQSRDVTGRVFEVEGGKVCVMEGFRHGPAVDKGARWEPAELGPVVTGLLAKAQDPEPVYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQX5</accession>
    <name>A0A1H6DQX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase family M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86995">
        <property type="protein sequence ID" value="SEG86995"/>
        <property type="gene ID" value="SAMN04489712_12048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296138" evidence="1">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="53"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="180" mass="19272" checksum="BF1DF8627606AFBC" modified="2017-01-18" version="1">MALIALVLTWAFSLASAVPSALPGPPGPWRWPLSPDPQVLRGFSPPLSPWGPGHRGVDLVATPGQAVYAAAAGQVSFAGYVAGHGVVVLTHGVLRTTYLPVIPSVRTGRHLPVSARLGTVQDLPGHCGPLHCLHWGLRHDLRYLDPLSLLRPGVRLLPYWSSQRRLQGVALHRAGSGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTT2</accession>
    <name>A0A1H6DTT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secretory lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88143">
        <property type="protein sequence ID" value="SEG88143"/>
        <property type="gene ID" value="SAMN04489712_12185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296210" evidence="3">
        <location>
            <begin position="47"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG88143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="419" mass="43444" checksum="D263251E6F0784A0" modified="2017-01-18" version="1">MKIPPPGTASRRRSRLRPALRAASAAALSAVLMLTGLVAGATAAQAAPTPSEDPFYTPPAPLPAGGPGTVIRSRESRFSADSTVKSWQVLYKSESATGASIAVSGTVLVPGARWTGPGPRPLVSYGVGTRGIGDQCAPSYTLSGGFDYESGLINQALQKGWAVAVTDMEGLGTPGMHTYEVGRSQGKAVLDIARAAQRLPGTGLTTATPVGLWGYSQGGTSTGWAAELAPTYAPELSLKGAAAGGVPADLIVVARYLDGGLGMGLAFTAAVGYDAAYPELNLAGYLNDAGRALLARGQSLCLVSADGISTYLGTAFKRISDYTTTDPLATPAWQRRLNENRLGSAAPAVPVFQGHALFDEIIPLTQADRLRRDWCARGANVTWKVYPLAEHALGLVGSMPDALRFLADRFAGTPVRGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVJ0</accession>
    <name>A0A1H6DVJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Phosphatidylinositol phosphate synthase</fullName>
            <shortName evidence="10">PIP synthase</shortName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_12344</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
            <dbReference type="ChEBI" id="CHEBI:144472"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Contains a di-nuclear catalytic Mg(2+) center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89219">
        <property type="protein sequence ID" value="SEG89219"/>
        <property type="gene ID" value="SAMN04489712_12344"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02241">
        <property type="entry name" value="PIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044268">
        <property type="entry name" value="PIP_synthase_PgsA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="CDP-DAG binding" evidence="10">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG89219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="22074" checksum="1C479CF813071FA4" modified="2017-01-18" version="1">MLNKLRPALGRVLTPIGRAVARTGVSPNTITVIGTVGVAAGALVLFPRGEFFWGTLVITAFVLFDMLDGAVARVTGRISKWGAFLDSTMDRVADAAIFAGLAVGLLDGDRRPAAFVALYCLVAGVVVSYAKARAEGLGYTCDVGIAERSERLIIVLVAAGLDGLGVPYVLVAALWALAALSTFTVGQRFAAVHRQTLDRPAEPRVPEPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DW65</accession>
    <name>A0A1H6DW65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class probable F420-dependent enzyme, Rv0121 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89439">
        <property type="protein sequence ID" value="SEG89439"/>
        <property type="gene ID" value="SAMN04489712_12393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019967">
        <property type="entry name" value="F420-dep_enz_PPOX_Rv0121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03668">
        <property type="entry name" value="Rv0121_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="8"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="16129" checksum="55B10A94BCEA2FF5" modified="2017-01-18" version="1">MPGLEAGEARRRLAGMPVARLATADGAGRPHLVVATFAVEGDRIHMAVDHKPKRTRELKRLRNIAENPWVSVLADHYEDDWTRLWWVRADGEARVVEEPPELERSVDLLVARYPQYRGHRPEGPAIVITVRHWVGWVYAGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DW96</accession>
    <name>A0A1H6DW96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89607">
        <property type="protein sequence ID" value="SEG89607"/>
        <property type="gene ID" value="SAMN04489712_1243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="51" mass="5189" checksum="9BA069FCD7A19755" modified="2017-01-18" version="1">MFVRRCGFLACWLVLALYVLRHPLGAADTVAAIGGGLAALADALAAFASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXS7</accession>
    <name>A0A1H6DXS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12549</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90137">
        <property type="protein sequence ID" value="SEG90137"/>
        <property type="gene ID" value="SAMN04489712_12549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="130"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="237"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG90137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="42233" checksum="B77342A2561CB34D" modified="2017-01-18" version="1">MFYDLTDGIELSDEQREFVALARDFARNEIRPRSRAIDEADTEAPMDLWAKAAEIGLAAYMLPAEYGGGGVTDLVTQCLVQEELCHGDIGIANFLTSSAFFADPILALGTEEQKKKWITPLTGSRPPVTSVAVTEPGVGSDAAGLQTRAVREGDHYVLNGTKTWISNAPLSQYFVVFATVDPSLRSRGVTAFLVERDREGVTVGAPMKKYGQRGTLNAEVFLEDVRVPVENRLGEEGKGFYGLMHTFDASRILIGAAATGLSRAILEDAVQYAQERTQFGKPIIEHQAVAFRLADMAAKTDISHLVTMRAARLYDAGKPATAASAIAKLTASENTTWVANAGLMTHGGWGYSREFLVEKWLRDAKLEEIEEGTSDIQRLIISRAVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E071</accession>
    <name>A0A1H6E071_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90861">
        <property type="protein sequence ID" value="SEG90861"/>
        <property type="gene ID" value="SAMN04489712_12760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045985">
        <property type="entry name" value="DUF5941"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19365">
        <property type="entry name" value="DUF5941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5941" evidence="4">
        <location>
            <begin position="367"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG90861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="507" mass="52437" checksum="9B50B80BCB4E5C6B" modified="2017-01-18" version="1">MTVALVLATDPAADLPYDSGPNAQSLLQRLLGQLVSLNVPDVRVLARPETAALLRKRPEGSGPAVEVVESDSPAGDLRAIARLARGATAPLLVLPGGTVASGELLARLAGPRSDMATAVTAPPPDPGGPDDPGLPPVRRGAGRIVSAGTGFHQVTDPNGVFCGLLRVAPAKRVTLARAAERLAALLETPGAMSGASGVLALLLVGLVRAGVRVTPLPAPPLVCAQVRDTEQVRAAREAVTAVNEDRVRLDAAVKSNDGFFTTFAVSTYSRYIAKLAARIGLTPNMVTSLSMAISVGAAVAFAMGTRTGMVVGAVLYYFAFVFDCVDGQLARYTRRFSTFGAWLDATFDRAKEYTVFAGLAVGSTAAAAGSSVHGGDVWPLAVAAMAAQTGRHMIDFAFGAARRARPATPLPVTPLTSPGDGLAPAGAAAPRRGGVLGLVKRVLARTRSGPAFWAKKMIVLPIGERFAVVSVTAALWNARVTFIVLLAWGAVAAAYTLTGRMLRSLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0I8</accession>
    <name>A0A1H6E0I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90425">
        <property type="protein sequence ID" value="SEG90425"/>
        <property type="gene ID" value="SAMN04489712_12633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG90425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1067" mass="115380" checksum="8EAD1649437856F7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E216</accession>
    <name>A0A1H6E216_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase, sigma subunit, ECF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91421">
        <property type="protein sequence ID" value="SEG91421"/>
        <property type="gene ID" value="SAMN04489712_12912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="136"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="211"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG91421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="332" mass="37094" checksum="DBC248C0057B008A" modified="2017-01-18" version="1">MSADTRLGELGVGGLGEVDEPAFSGLVERYRRELHVHCYRMLGSFEDAEDTVQETFLRAWRRRETFEGRSTFRAWLYRIATNACLDLLAKCRPEPATGGEVLWLQPYPDRLLDELPAGDEDEPETVAVARETIELAYLVAVQHLAPRPRAVLILRDVLGWPAKDVAELLGDSVNSVNSALQRARAGMREHLPAERQDWTGGEEDAGTRELVRRFTDASVATDIDGLAALLRDDVRCSMPPTPGLHVGRDTVVNDWVEDGFEGMKGLRAVQTSVNRQPAVAFYQWREQEGAYLPLTIDVLRVTGGAITEIFTFHDDRFPRLGLPERLPADGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2M5</accession>
    <name>A0A1H6E2M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemopexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91631">
        <property type="protein sequence ID" value="SEG91631"/>
        <property type="gene ID" value="SAMN04489712_1303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028708">
        <property type="entry name" value="72kDa_collagenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018003">
        <property type="entry name" value="Insecticidal_toxin/plasmid_vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041079">
        <property type="entry name" value="Neuraminidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040840">
        <property type="entry name" value="TcA_TcB_BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF29">
        <property type="entry name" value="PTHR10201:SF29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18413">
        <property type="entry name" value="Neuraminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18276">
        <property type="entry name" value="TcA_TcB_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03538">
        <property type="entry name" value="VRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="SSF50923"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Neuraminidase" evidence="4">
        <location>
            <begin position="2621"/>
            <end position="2760"/>
        </location>
    </feature>
    <feature type="domain" description="TcA_TcB_BD" evidence="3">
        <location>
            <begin position="3897"/>
            <end position="4180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="3751"/>
            <end position="3785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="4309" mass="467540" checksum="509D123AB81C6BEB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3P7</accession>
    <name>A0A1H6E3P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacid CoA-transferase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91909">
        <property type="protein sequence ID" value="SEG91909"/>
        <property type="gene ID" value="SAMN04489712_13124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="22863" checksum="732C91288DDFA6EF" modified="2017-01-18" version="1">MSGWTRDQMAARAATELRHGDYVNLGIGLPTLVPDHIPPGVRVMLQSENGLLGLGPYPAEDEVDPDLINAGKETVTVVPGASFFDSALSFGMIRGGRIDVAVLGGMQVSARGDLANWTVPGRLVKGMGGAMDLVHGARRVVVVMEHRTKAGAPKILEDCTLPLTGVRCVHRVITDLGVIEVTPDGLTLVECAPGVTFATVQAATDAELRPATVGHRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E436</accession>
    <name>A0A1H6E436_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellobiose transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92081">
        <property type="protein sequence ID" value="SEG92081"/>
        <property type="gene ID" value="SAMN04489712_13216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296528" evidence="1">
        <location>
            <begin position="29"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="438" mass="46902" checksum="B73FD6DAB502EAE7" modified="2017-01-18" version="1">MRRPHPRAPRRFRTISSLVTAAALALGAAACGGGGSESSNGTITLTVDTFSTFGYEELFARYEADHPGIKIKHRNVVQLDEYLPRLERWIAAGRGAGDVVALEEGILTKFMAQPDRFVNLLDHGAGSMQGGFLDWKWKQALTRDGKHLVGLGTDVGGLAMCYRTDLFAKAGLPTDREKVGALWRTWDDYIATGRRYTGKVKDAKFVDGAVNLYNSILAQQASQTVGHTYFDTGDKLVAGTNPAVRSAWDTTVKMQQAGLSAGLKSFEPSWGTGLKEARFATIACPSWMLGVIKENAGAQAAGKWDVAAIPGGAGSRGGSFLAVPKQSAHPKEAAELAKFLTGPDSQITAFKARNNLPSSPKALGDPAVTSFRNEYFSDAPVGEIYAGGAKALRPLYLGADNNPVGQRFEDALLALEQGKLAPDAAWRKALADAEREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4M0</accession>
    <name>A0A1H6E4M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92567">
        <property type="protein sequence ID" value="SEG92567"/>
        <property type="gene ID" value="SAMN04489712_13436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="14564" checksum="FA2E10A6A44E134A" modified="2017-01-18" version="1">MKIFGRDPAAWLALVAVAVQFLVAWGVDLSEAQQAGINAVATMAMGLAISWVVAKDKVIPAAAGLLTAVLQLMVSFGWDISQQQIATAGAMVTAVLGLYLRTQVTAPVAQDGSRVPTEGPLSRNPGPDGPSPAPQRVSEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4P9</accession>
    <name>A0A1H6E4P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91855">
        <property type="protein sequence ID" value="SEG91855"/>
        <property type="gene ID" value="SAMN04489712_1312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="30628" checksum="A92D70E3629129EA" modified="2017-01-18" version="1">MNRDGPVPGVASLHVVGGTVLLRPEEQVAEAMLAGGRNQQLARNLAHSTIEGRQNAVKAFTHDELQAFSDYADDQVHRISGAGRKGWLPAFRDATLFKTAYTYGLRRRETRMLDLIDFGANPHAPIFGDIGVCYVRWGKAMKGSPPKRRSVLTVEPRDEIGGMDWVVDTLDQWVTEVRPAFAQAATSPASGRPESAQRRGFRCDPSDPMMVLCALRTICSGRPSAGWAGACGGCAMSWRRLPSPVSVACSGRAASVSSPSPCSAQRWSTRSGPPSIGCGTGGAWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E500</accession>
    <name>A0A1H6E500_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92770">
        <property type="protein sequence ID" value="SEG92770"/>
        <property type="gene ID" value="SAMN04489712_13525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="355" mass="37680" checksum="9DE34441A9078121" modified="2017-01-18" version="1">MTDMTTDHTGVDELREAAIAELRSAGTLASQEVEAAFRAVPRHTFIPEADLATAWAPYRAVVTKRDEHGNALSSVSDMHVQSYMLTEARIEPGMNVLEIGSGGYNAALIAELVGPDGRVTTVDIDEWVTDRASRLLDAAGYSSRVEVVLADAEAGMPDGAPYDRILVTVGSWDIPPAWTEQLADDGLLVVPLEPGRSAAPCHTRSRPATRPPCGFGPELVHQLPQRLLAPSHRREHHVADLLVGAAKAVSAMGAGCSPSRLSCLSEIVIARRCRGPGLLGRWHRCGWAESDVPRGAPALLEAGGGAFASTREYALSAEGRRRVPTPGTGLGVCAEARCAAHVSLGIGGKSRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E682</accession>
    <name>A0A1H6E682_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92476">
        <property type="protein sequence ID" value="SEG92476"/>
        <property type="gene ID" value="SAMN04489712_1348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="9043" checksum="E69161666B2BEE72" modified="2017-01-18" version="1">MTTADENHASAELLLGGWYTTEQLAEIIGVDPSTLRRWRTSNPVQGPPFVRMSGAVTRYSVLDVERWLANRRIDPREADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7R1</accession>
    <name>A0A1H6E7R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted metal-dependent hydrolase, TIM-barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92986">
        <property type="protein sequence ID" value="SEG92986"/>
        <property type="gene ID" value="SAMN04489712_13637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="100"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="44586" checksum="7E721A3067FBF356" modified="2017-01-18" version="1">MPSRELPYPLFDADNHLYETEDAFTRHLPKEYQGAIEYVQVRGRTKIAIQGRISEYIPNPTFEKVARPGAQEDYFRHGNPEGKSYREIVGKPIESIPAFREPGPRLELMNEQGIERALMFPTLASLLEERMRDDPELTHAAVHALNRWLEEVWSFNYQDRIFTAPVITLPIVEEAVRELEWCLERGARVVLVRPAPAYGVHGPRSIALPEFDPFWKLVQDSGTLVAFHSSDSGYQRYTADWEGKQREYLPFTLQPFREIGQWRAIEDTVASLICHGCLSRFPDLKIATIETGSSWVGPLLEKLAVIHKKMPQGFQEDPVEQMRRMIHVSPFIEDDMAALADLLGTDRVLFGSDFPHPEGKADPITHVDDLATLSDEAKAKIMGGNLSRLIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E846</accession>
    <name>A0A1H6E846_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_14113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93867">
        <property type="protein sequence ID" value="SEG93867"/>
        <property type="gene ID" value="SAMN04489712_14113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="57"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG93867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="33466" checksum="630A494ED62C1C11" modified="2017-01-18" version="1">MNTAIFAVARRRGVTLVHDPATGLTHRAARDLPGGRVSLRPDEVTSWPTVAPRDHEEDVPISVCWSPLVRCNLSCPHCLDDKEIREQSPAERVRIAELIGSAGVMGVDLSGGEPLLLGGLDVLADILTAAGCVVSVTTNGWHLRRRAPALTSHLDAVRVSLDGPTARLHDAWRGEGSFERAVDGVQAAVAAGLRVQIQTVLMASTCRNAQRLVDLAAGLGAGGVTFLQMLPIGEGRRLAHQEMIPDETAAELIQTLSVPRPLTVRMRAREDAGGFTVIRADGQIWRNDHPAASISTLRPLTATGDLALTGPDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E863</accession>
    <name>A0A1H6E863_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93912">
        <property type="protein sequence ID" value="SEG93912"/>
        <property type="gene ID" value="SAMN04489712_14131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010152">
        <property type="entry name" value="CRISPR-assoc_prot_Cas2_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09707">
        <property type="entry name" value="Cas_Cas2CT1978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01873">
        <property type="entry name" value="cas_CT1978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="13324" checksum="5CDB57E36651C988" modified="2017-01-18" version="1">MTIIILTRCPTGLRGFLTRWLMEISPGVFIGGPSARIREALWREVRQYADTGRALLAYSTNNEQGFTFETWDHKWHPVDHEGITLIRRPKAQSTISATPPPTGWSKASKRRRYGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8M5</accession>
    <name>A0A1H6E8M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93479">
        <property type="protein sequence ID" value="SEG93479"/>
        <property type="gene ID" value="SAMN04489712_13910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="187" mass="20422" checksum="DE1D3D100C27038A" modified="2017-01-18" version="1">MPAEPALTADSGRPPPAPVEFRRAMAEFATGVTVVTGLDGGEPVGFACQSFASVSLQPPLVLFCADHRGRSWPRIRAAGRFCVNILGEDQQELCERFGSSRGLRYEGLDWEVSRWDTPALPGVLLRVHAVVHEVHPAGDHDVVLGRVLAAERVTAGRPMIFFRSRFGIDEPDAPIAPDLWARGDRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAC0</accession>
    <name>A0A1H6EAC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94069">
        <property type="protein sequence ID" value="SEG94069"/>
        <property type="gene ID" value="SAMN04489712_1432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="613" mass="67890" checksum="F41CC74BD65D282E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAQ8</accession>
    <name>A0A1H6EAQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quaternary ammonium compound-resistance protein SugE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94313">
        <property type="protein sequence ID" value="SEG94313"/>
        <property type="gene ID" value="SAMN04489712_1467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG94313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="10930" checksum="BE37A7E57889D393" modified="2017-01-18" version="1">MTWIILFCAALLECVWAVAFKQSDGFTRPWPAIVGVVTAVASVVLLAIALRALPVGTAYAVWTGLGAVGVAVVGIARFGESASPARLGFLTLILVGVAGLRFLESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBA2</accession>
    <name>A0A1H6EBA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94065">
        <property type="protein sequence ID" value="SEG94065"/>
        <property type="gene ID" value="SAMN04489712_1431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="88" mass="10034" checksum="094764BF52E64C5C" modified="2017-01-18" version="1" fragment="single">SFIPFLAFPAEIRKIVYTTNAIESLNARFRQATRRRGHFPTEQAALKVLYLVIRQPLKNRPNVTGRTPGWKAALNALSLHYGDRITVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBH3</accession>
    <name>A0A1H6EBH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94276">
        <property type="protein sequence ID" value="SEG94276"/>
        <property type="gene ID" value="SAMN04489712_1458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="233" mass="26588" checksum="A022748634F036ED" modified="2017-01-18" version="1">MRLVPVRFWQHGRAMMRTPRSGEPYWCAPHPPNADPLPRDGRRNCGFWERVLRRQWDPGQGVPPAETIAVIDRLAAQPVHIASLAINELDELWVGVGAVPQLDHLGYLSGQPIGPGSAIVWDDVPGATVGRTVVIGTGRTVSSSLVDHELGHVIERSRRMAEQRDWQTIMLRCRPHLIVERWYDPLEWWAEAWAMVSTGQLQRLVRTLNGHEEVAEMVARYYVRRYGLEVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S1V2</accession>
    <name>A0A1H5S1V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44592">
        <property type="protein sequence ID" value="SEF44592"/>
        <property type="gene ID" value="SAMN04489712_10147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="76"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF44592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="339" mass="36219" checksum="210C126BAB8DBF35" modified="2017-01-18" version="1">MDIMVPTAPPTPCGHFFRPVPGSARTASRPWSSRLLAAPPVWRELLLLVLFYSAYTLTRLVLNGGGTAVAFQNAGEILALERALGIDVELSLNEALLEVSWLARAANYFYGTAHFAVTLGIVVWLYRYRPQHYRWLRTALMAATAVALLGFWLYPLAPPRFLPGEGFVDPVQALGSWGLYSGQSAGTLTNQYAAMPSMHAGWALWCGFVLVLLGTQRWVKAVGVLYPLVTVLVILATANHYIVDAVVGVALVLGALALSRALYARRPVLLARRPRTGPAAGSPACERVTCDAPAMPRLVPVPSASVRPGRDAAPPVPPSRSPGEGGDSPVAGDASMTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SLQ4</accession>
    <name>A0A1H5SLQ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51506">
        <property type="protein sequence ID" value="SEF51506"/>
        <property type="gene ID" value="SAMN04489712_101268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="16"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF51506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="233" mass="23510" checksum="F84DF0436B4FE9CD" modified="2017-01-18" version="1">MSAREDELAANLAGVRARVAAACAAAGRDPAEITLIAVTKTFPASDVRLLAGLGITDVGENRDQEAAPKAAECADLSLTWHFVGQLQTNKARAVAAYADVVHSVDRSRLVTALSAGALRAGRTLRCLVQVSLDERPGGRGGAAPGQVPELADLIAASEGLELGGVMAVAPLGADPAPAFARLAEVAAAVRAAHPAATAVSAGMSEDLEQAVACGATHLRIGTALLGGRDAIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SW43</accession>
    <name>A0A1H5SW43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54750">
        <property type="protein sequence ID" value="SEF54750"/>
        <property type="gene ID" value="SAMN04489712_101387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF54750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="27330" checksum="F0DD74594C289F77" modified="2017-01-18" version="1">MNTDTDNEGVRLQKVLADAGVGSRRNCEKLIAEGRVKVDGKVVSWFGARVDPARVVIHVDGLRVETRPEMRYYAVNKPRGVVSTMSDERGRKSLADYVDVPERLFHVGRLDTDTEGLILLTNDGELAHRLTHPSFGVEKVYLAEIIGPVPRDLGRRLREGVTLDDGLARADRFTLVEQLGKRALVEVTLHEGRKHIVRRMLKEAGHPVQKLARTQFGPIRLGGLKSGGLRALTMKEIGELYKAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T1V4</accession>
    <name>A0A1H5T1V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted metal-dependent hydrolase, TIM-barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56724">
        <property type="protein sequence ID" value="SEF56724"/>
        <property type="gene ID" value="SAMN04489712_101448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="78"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF56724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="44675" checksum="B1D8280C301D130A" modified="2017-01-18" version="1">MDDGKYTLISTDSHAGLPAEQYREYVDPKYRRAFDEAAAEAEALRQLAETDDHQRFLAEWDKEIGEHGGMRGAWDPAVRNKEMDHDGVAAEVVFPDADSAGVGGVTKTPFTAGLGSTGDDDAELTLAGAWAHNRWLVEFCQDSPERRAGVAIVPLHDVPAAVQMIEWTAAQGLRGGIMIPTKWGRLPSYNDPVYDPVWSAAAATGLPVHTHSGVGPDPDDYGITPGLIAIYTTEAYWWAARPLWALILGGVFERHPALKYVIAENGAWWVPDIISRMDSKWEGDHATRKFGPAAFRSGLSIKPSEYFDRNVWLAASVMGDIEVERREQIGVGNLMWGSDYPHPEGSWPNTRQWLADRFRNVPQGDVRRILGLTAAQVYGFDLDALAPHVQRVGPTVRDVHGPADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TAG4</accession>
    <name>A0A1H5TAG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59815">
        <property type="protein sequence ID" value="SEF59815"/>
        <property type="gene ID" value="SAMN04489712_101546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="76"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF59815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="27512" checksum="16757991793DE821" modified="2017-01-18" version="1">MAEQTRRRSGAESSRKAAQLLLAFDERHHTRSVADLAGALGMPVSSVYRYLTVLRETGMIEEAGPGEYRLSWVFVRLARAARAAGDTLESVARPVLASVAEAGGETTLLIKRIGWNAVCVDRVDSPHPVRLQFDPGQPMVLHKGSAARVLLASMPAAERRRYLASVSGLSEHERDQIEADVDTVARMGWVESFGEVDDGIWGTSAVIRDQDEVIAALGVAGPLYRLQQADRARITDLVVSGAAEISAALARGVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TKX4</accession>
    <name>A0A1H5TKX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR HTH family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63445">
        <property type="protein sequence ID" value="SEF63445"/>
        <property type="gene ID" value="SAMN04489712_101660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF63445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="21792" checksum="A4A0CF15742C92C3" modified="2017-01-18" version="1">MAVSSGEGKAHSEHPDRHVASQRAGEQGLLFDTQVSAPPENVGYRGPTACAAAGITYRQLDYWARTQLVEPSVRAAHGSGSQRLYSFRDILVLKVVKRLLDTGVSLQQIRTAVSHLRDRGVRDLAQITLMSDGVSVYECTSADEVVDLLAGGQGVFGIALGRVWQEVEGSLAELPAERAVRDEDPHPHDELARRRVRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TPC3</accession>
    <name>A0A1H5TPC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64599">
        <property type="protein sequence ID" value="SEF64599"/>
        <property type="gene ID" value="SAMN04489712_101697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="10"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF64599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="377" mass="40419" checksum="AA79FA65BF0513F3" modified="2017-01-18" version="1">MQPAELKNLTIAVVGAGYGGAAAAKALSLLGATVNVYEQASRIREVGAGIGLRPSTMDRFRQWGIVDAIQQVSSPSDYFEILTATADPIMKEPWPEIDTFGERTHLIHRGDFIEALLGVLPEGMVHLGHKLESVGDEGDKATLTFANGESVTADLVVGADGIKSVVRGQLFGGGRPVFSGEHAYRAVISVDDAHGMAVDDNLRMYLGRGTKVYFLPLRHRGQVSFDITALCPDSTWTPAVTKDDLLKTVEGFDERIVNITRGLDLDAVNCRAVYDIDPVDTWHSDSVVLVGDAAHSMLHHQGQGANSAILDAGALADALQEAGSVGEALALYQATRKPVTDELQRISRQGWTEDEINDVFPGQKPASQKPASPKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TQ32</accession>
    <name>A0A1H5TQ32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64191">
        <property type="protein sequence ID" value="SEF64191"/>
        <property type="gene ID" value="SAMN04489712_101685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF64191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="20756" checksum="1BE48D3BC22E53BB" modified="2017-01-18" version="1">MATASRTKAERRREALVDRLIEVFLDRGFAELSVADLAAALRCSKTTLYLVAASREQIIVTVVRAFFRRAAERVEAAVDTGADPGRRVGAYLRAISAELAPASPAFFTDLDAFPPAREIYRQNTQIAARRVRELVGEASPDADASFVGAVAGLVMEAVHRGEIKAMTGLADSAAYAALADLIIARMSTASGREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TTZ3</accession>
    <name>A0A1H5TTZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66342">
        <property type="protein sequence ID" value="SEF66342"/>
        <property type="gene ID" value="SAMN04489712_101747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF66342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="29185" checksum="0D2835A90A0D43DA" modified="2017-01-18" version="1">MRVLVTGATGTVGRHVVDGLLRSGASVRALTRSPETAGLPGEVDVVRGDLTLPESVQPALADVDRLYLFPVPETAEAVMGLAAKAGVRRVVVLSSVSAEYAEGDLSGDQHRAVEAAVEASGIEWTHVRPGEFMANLLFLWAPFVKAEGVVRAPYGDAESAMVHEADIADVAVRALLEDGHAGAKYSLTGPEALTKVEQVRILGEVLGREVRFEELTREQTRELWIGQGMPPEAVDWLLTPPPKAVVGPTAEQVTGRPARTFAQWVADHRADFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U071</accession>
    <name>A0A1H5U071_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OB_aCoA_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67677">
        <property type="protein sequence ID" value="SEF67677"/>
        <property type="gene ID" value="SAMN04489712_101789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF67677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="15336" checksum="4A7C33FFB4B3865F" modified="2017-01-18" version="1">MSGMFNDVAVLPLMPVEDDHDTGGFFAAARRGELALRFCSECGQLLHLPRQVCFACGGARSEWRAVPGRGRVHAWTTVTHQVHPAFPTPYTVVLVDLEEIDARLVGSLPGEAELEVGQPVRVRFDRAPDGTTVPNWEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U0H3</accession>
    <name>A0A1H5U0H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68500">
        <property type="protein sequence ID" value="SEF68500"/>
        <property type="gene ID" value="SAMN04489712_101819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF68500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="41871" checksum="DE48B7E997287645" modified="2017-01-18" version="1">MDFSLTAEQQLFRDTLRDFVNKEIRPVAQEWEASGRYPTEIVDGMRELGLFGLTVPEEYGGLGVDMVSFALVFEEISKGWMGIAGILGSHSLACWMINKHGTEEQKARLLPDLATGARRTGIGLTEPGAGTDLQGISTTARLDGDHYVVNGSKTWITNARHADPLPVLVKTDPTARPAHKGMSVLLIDADTPGFTVSRDLPKLGYKGTESCEITLDDVRVPRQNLLGGVEGRGMQQVLSGLEIGRINVAARSLGIAQAAYDEALSYAAQREAFGRPIHDFQAIQLKIAEMAIKVQASRLLVYWAASQADAGHRVDMEAGMAKTFASEAAIECALTSMQVHGGYGYSKEFVVERLYRDAPLMSIGEGTNDIMRTVIAKVLTSGQGVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U0L3</accession>
    <name>A0A1H5U0L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68672">
        <property type="protein sequence ID" value="SEF68672"/>
        <property type="gene ID" value="SAMN04489712_101825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF68672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="29205" checksum="73D14BA815088DBE" modified="2017-01-18" version="1">MALGAIIEAVVVCRDVEASIGFHARAFGLEVIERNGAEALMGVRGVGTGRLRLRPAAAGREAEEPRVWDLGPRLLGMYSRDLERSTRLIDEAGGRSRQPVTYPYGSASLSEAVALGSDGLWWTLPKAGPGHRPSPALEGDPQRLHGELHTAVLVPADHEEALRFFTEAGGLEVAFDGAMSGEPFERMIGMPPGASLRLSFLVSADQAPARLEIMSFTGVQARDLSDRPLGLRRLVFAADDPDATAAALEAAGGVRIGERVLRGPAGVEVELRGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U0P6</accession>
    <name>A0A1H5U0P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68645">
        <property type="protein sequence ID" value="SEF68645"/>
        <property type="gene ID" value="SAMN04489712_101824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF68645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="37884" checksum="939864BC31C1D0CC" modified="2017-01-18" version="1">MSQDDVVEPVTAYRAVALQSTCRAINRAPSTAAARDMIRAAIDQVADQVEATQRFVGGLRLVVLPEYLLTGHPIGEPLPEWCERAALDPDGAEYARLAELSRDSGLFLCVNAYELDEHFPGLYFQASVVFDPRGKTVLRYRRLNSMFAVTPHDVLDRYLSIYGEDALFPVARTEIGNLAAIASEEILFPEVARCLAMRGAEVFLHGSSEVCSALLSPKNVAKLARAAENGAYVVSANTSGVYGMGLPAHSADGGSQIVDYRGNVLAKAGQGESMAANAELDLAALRRMRRTPEMMNLLPRQRFELYAPSYAGTSFYPPDTVRPGETERGHFLSTQRAVIDRLAADGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U158</accession>
    <name>A0A1H5U158_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter substrate-binding protein, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68776">
        <property type="protein sequence ID" value="SEF68776"/>
        <property type="gene ID" value="SAMN04489712_101828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009285684" evidence="3">
        <location>
            <begin position="26"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="46"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF68776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="409" mass="43270" checksum="56F74A5732EF270A" modified="2017-01-18" version="1">MRRSTIRWASALAAGALVLAGCASKEERAGDKAAGGSGWNAGSGAVKIGLISPMTGPYAILGILQQNSIQVEMDRINQAGGIGGAKLELVVRDSALDPGKAVQAANELVGDNQIRMVVGPSLSAFYNAAKDTYEQNAKINCQPGVGTGDFSVLKYGFRSQDPNYIGVEKLMQYFKSKGVTSVGLVYEADDAGKANDGFIAELAPKYGIEYLGFQQTRPDDQTHRPYVDKLKGAGAIMVSSNVSGAKTMAAAGEAGYQGVLAGTSGLQNVSFLDAAGDRAIDSVFSAVNVQFNIRDRASWKPGYRDHVDTIVKKYGVIEGPKSGAKMPKGTAIAADCVTAFAAAAESVKTLDPDKIASAMTKLDIPDTETPSGNRIKPADHEFYHVEDLHIYRWDKDGQGWFITDVTPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UXZ8</accession>
    <name>A0A1H5UXZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79321">
        <property type="protein sequence ID" value="SEF79321"/>
        <property type="gene ID" value="SAMN04489712_10259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="3"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF79321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="40023" checksum="458CF7F7224F427E" modified="2017-01-18" version="1">MTYLDHAATTPMLPEAVEAMTAELGRLGNPSSLHAVGRRARRIVEESREIIAGAFDARPSEVIFTGGGTEADNLAVKGIFWARRAADPARVRVLAGAVEHHAVLDAVQWLADHEGAQVEWIPVDGLGRVDPAAVREMIGPGGGDDIALITVMWANNEVGTVQPVAELAALAREHGIPFHTDAVQAAAQLPVAFAGSGAHALTLSGHKLGGPLGVGVLLLAKGTDPVPVLHGGGQERDVRSGTLDTPAIAGLAAAVEITASRWEEQARSLSALRDELIARVMAAVPDAVLNGDPVHRLPGNAHLSFPGCEGDALLMLLDARGIECSTGSACSAGVAQPSHVLLAMGAGPERARGSLRFSLGHTSTEADVAALAEAIGPVVERARRAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V4W0</accession>
    <name>A0A1H5V4W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81808">
        <property type="protein sequence ID" value="SEF81808"/>
        <property type="gene ID" value="SAMN04489712_102147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF81808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="234" mass="25427" checksum="624E5E8FCC543196" modified="2017-01-18" version="1">MGCGAGRHAFELYRRGAHVVAFDLDADELAGVEKMFGAMRLEGEAPEGATARTVQGDARDLPFPDNSFDKIIASEVLEHIGDDMTAMGELLRVLKPGGRLAVTVPSWLPERICWALSEAYHTAPGGHIRIYTRAELEAKLKSLGLRVDGHHHAHGLHTPYWWIKCAVGVDNAGNPLAKAYHQLLVWDIMKRPLVTRLAEQVLNPVLGKSVVVYTTKPSTPGVPDAGGKEKVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VHT4</accession>
    <name>A0A1H5VHT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_102332</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86935">
        <property type="protein sequence ID" value="SEF86935"/>
        <property type="gene ID" value="SAMN04489712_102332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="9">
        <location>
            <begin position="212"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF86935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="332" mass="36405" checksum="7919DC14B6A8A526" modified="2017-01-18" version="1">MAMAQAQPDTEDFERLADPFRRELMAHCYRMLGSVHDAEDLVQETYLRAWRAYDRFEGRSSLRTWLYRIATSACLSALESKSRRPMPTGLGAPSADPGDDLVEQSEVPWLEPVPDALVGAEGTDPAAVVTSKESIRLAFVAALQHLPPRQRAVLILRDVLKWRAAEVAEAVGTSTAAVNSILQRARAQLERARPSEDDVAGPLTAEQRALLDRYVEAFEAKDVPAIVALFTDDAVWEMPPFPAWYRGPADIGRHLAERCPAGPGDLRILPLAANGQPALAKYLRDPADGMYRPFNLQVLTLAGDGISHAATFLDTGLFPVFGLPEALPARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VMN4</accession>
    <name>A0A1H5VMN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Virulence factor Mce family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88453">
        <property type="protein sequence ID" value="SEF88453"/>
        <property type="gene ID" value="SAMN04489712_102379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="114"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF88453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="36688" checksum="FE043766749F9A25" modified="2017-01-18" version="1">MRRLLVLATTAAMAVSLGGCSLLGGDGGRREMTVEFAKARSFYPGSKVKIMGTDVGSVDSVENLGDRIRVRFHLRSDIPLPAGVHASIVPLNLVGERNLVLHPPWKPGLPKETGDQIPMQRTSVPVEVDDALDSFTKLSNALDPTQVNKALGGAAESFKGNGQSFNATLEQAGRLVENIAGQDEELLEVARNLDRLAGVVRGREQVLGQMISDFGEATRVLAAERGELQDLVRGVLELTEQGDKLLKKYKGQLPYDLAVLTRFALSLQGQSKRVAQLLDALPEVSNALIGGYNPKAKALNLRFATDVFLRTWLTGLMGTDDVPCPLPEPNSNCPWQQGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VQR8</accession>
    <name>A0A1H5VQR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6286 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89308">
        <property type="protein sequence ID" value="SEF89308"/>
        <property type="gene ID" value="SAMN04489712_102410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046253">
        <property type="entry name" value="DUF6286"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19803">
        <property type="entry name" value="DUF6286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6286" evidence="3">
        <location>
            <begin position="99"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF89308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="22339" checksum="7EEE6086DD0ECBC3" modified="2017-01-18" version="1">MTTHAGQRRPARTSPAQAPTVDRTARRAARRAFRPRRRLPALLVSSLLIAAGVIVAAEVISTLVGSPLRLVDYGRAVSWLTGTSWNDPATRAAAAVISLLGLACLLAGLRPGHTSLIPLRSDDPHLVMGVTERGLRRAVAAAAADVEMITSVRRVKVRRHRVIVEAETALRDPGGLTRQVGAAVTRRLEELGPRPRRAVSVRVRSTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X5M2</accession>
    <name>A0A1H5X5M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07054">
        <property type="protein sequence ID" value="SEG07054"/>
        <property type="gene ID" value="SAMN04489712_10399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="150"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG07054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="34381" checksum="0E86A0DA508BCB1B" modified="2017-01-18" version="1">MSVTTGDIAAVRRFNRFYTGVIGVLGEGLVRTPYSLTEARVIFELAQREATEVVALRRDLDLDPGYLSRMLARFESQGLVARERSAEDARRQVVRLTGTGRDVYAMLDERSSQDIEAMLARLPAGRRDRLIGAMRTLQHLLQEPAGRGECVLRPPRPGDFGWVVQRNGALYAEEYGWDRTYEALVARIVAGFAEDHDPRREAAWIAELDGEPVGSVFCVRKDDTTAQLRLLLVEPSARGTGIGSRLVDECLRFAKGAGYAEIMLWTNDCLADARRVYQRAGFELRDEEPHHSFGHDLVGQYWGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X7H7</accession>
    <name>A0A1H5X7H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type nitrate/sulfonate/bicarbonate transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07694">
        <property type="protein sequence ID" value="SEG07694"/>
        <property type="gene ID" value="SAMN04489712_103123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="87"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG07694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="31241" checksum="02E7D09F35813667" modified="2017-01-18" version="1">MTSMTSTTAPPAVPARGRRRGGIRLAGRLTQRWLPFVLLVGVWEAVTRATASPFFPPPSEIVAATGDLWLSGPAHRLFLTDLAMDNLLPSLGRMLLALAGSAVVGIGVGIALGRSERVFAYLNPILQFSRAVPPPTLVPVFIVLFELGTQMQVASIIFSAIWPILLNTADGARSVTPLQMDTAEVFRLSAVDRIRYIIIPSALPKIFAGLRLALSLSLILMVFSELLPGTSNGIGFQLTDAQSRSDMPAMWSVIVLLGVLGYLLNTILLAVEHRVLDRRRPARTNGKVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XAI8</accession>
    <name>A0A1H5XAI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, DUF2236 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08759">
        <property type="protein sequence ID" value="SEG08759"/>
        <property type="gene ID" value="SAMN04489712_103167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="42"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG08759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="33771" checksum="BF600C56148CEDCB" modified="2017-01-18" version="1">MTTTEDQATGRSPVRVRAPGPRPFGPGSILWDEAGLHLPAIAGNSAFILQAMHPAIGTAVDRLPGFRTDPVGRAVRGFTSVQTWVYGGQAAVEEGRRLRRMHRPPSAAGQDGRRHRALSPSPWAWAHLSGYYTVLTVLRYFSRTPMTLEREEQIFEEFRGLGRILRVPERMLPTTVADYWVYFDAMLAGTLVPHPVAFEVLERMDKVAPAVPVWLRPLLVPFGLTGGRFARFVAVGTLPEGARRKLGLTWTPADERKLQAVGTATARAAPLLPERLRYTPVAYRARQAARARESLEEALIRRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XFJ7</accession>
    <name>A0A1H5XFJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-dextrin endo-1,6-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.1</ecNumber>
            <ecNumber evidence="5">3.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pullulan 6-glucanohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_103232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic linkages in pullulan, amylopectin and glycogen, and in the alpha- and beta-limit dextrins of amylopectin and glycogen.</text>
            <dbReference type="EC" id="3.2.1.41"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="3"/>
    <dbReference type="EC" id="3.2.1.41" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10522">
        <property type="protein sequence ID" value="SEG10522"/>
        <property type="gene ID" value="SAMN04489712_103232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10315">
        <property type="entry name" value="CBM41_pullulanase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005323">
        <property type="entry name" value="CBM41_pullulanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011839">
        <property type="entry name" value="Pullul_strch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024561">
        <property type="entry name" value="Pullul_strch_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040671">
        <property type="entry name" value="Pullulanase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045041">
        <property type="entry name" value="Pullulanase_PULA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43631">
        <property type="entry name" value="PTHR43631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11852">
        <property type="entry name" value="DUF3372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03714">
        <property type="entry name" value="PUD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17967">
        <property type="entry name" value="Pullulanase_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02103">
        <property type="entry name" value="pullul_strch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="8">
        <location>
            <begin position="32"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG10522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1873" mass="204294" checksum="A0C394A7C3E67214" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XGJ4</accession>
    <name>A0A1H5XGJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_103247</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10954">
        <property type="protein sequence ID" value="SEG10954"/>
        <property type="gene ID" value="SAMN04489712_103247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="437"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG10954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="480" mass="52998" checksum="D884E585435DF3AB" modified="2017-01-18" version="1">MTAFSADQQTERSGRSAARFPQDFRWGAATSAYQIEGAAAEDGRGRSVWDTFCDTPGAVLGGDNAAEAVDHYHRYREDVALMADLGFNAYRFSVSWPRIQPTGAGAADRRGLDFYSRLVDELLAAGIEPWLTLYHWDLPQALEDRGGWPERDTALRFAEFAALVHGALGDRVRNWMTINEPWCAAYLGYASGEHAPGRREPAAALYAAHHLLLGHGLALEAMRGQRRDTRIGPAVNLYAVTPATDAPEDLDAARRIDGLQNRFFLDALLHGRYPADLLADLAPFGFEDCVQDGDLEVIGGRNDLLGINYYTRHTVSGLPGDGVQAVSSPFSSVSPWVGSEHVRFLGQGRPVTGMGWEIDPDGLREVLDQVCRDYPAVPLYITENGAGYEDAPDGDGTVQDPERIAYLDAHLRTCQEAIADGVPLKGYFTWSLLDNFEWAWGYSKRFGLVYVDYATQRRIPKASAAWYARVIRQGGLPDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XJM9</accession>
    <name>A0A1H5XJM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trk system potassium uptake protein TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11610">
        <property type="protein sequence ID" value="SEG11610"/>
        <property type="gene ID" value="SAMN04489712_103274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG11610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="217" mass="23613" checksum="4F87ADDA425023B4" modified="2017-01-18" version="1">MGCGRVGSTLAHILEDKGHSVAIIDQSPEAFRRLRGGFRGRRVTGVGFDRDVLEEAGIEQASAFVAVSSGDNSNIISARVARETFGVENVVARIYDPRRAEVYQRLGIPTVATVRWTADQMLRRLLPDGALPLWRDPTGEIMLAELSVGEAWIGTKVTAFEEAVRTRVAFLSRMGEAIVPDADTVIQDGDVVHVMARSDDKDRLNKAVAQPADGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XNB3</accession>
    <name>A0A1H5XNB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12726">
        <property type="protein sequence ID" value="SEG12726"/>
        <property type="gene ID" value="SAMN04489712_103313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG12726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="247" mass="27672" checksum="75EC09ADDFA44ABA" modified="2017-01-18" version="1">MKAAPQAQQRLLDLQELDTALDRLAHRRRTLPETAEIERIEARVAELRDALVAAETEVSDLDREQRKAEQDVDQVRTRAQRDQQRLDSGMVTSAKDLSSLQSEIASLQRRQSDLEEVVLEVMERREEAEGRVAGLREERTAAERDLAEATERRDAARQRIDEESGTTSAARTAVAKDVPEDLLGLYEKLRGQFGGVGAAALHRGQCQGCHLALNTVDLNRIRAAAQDEVVRCEECRRILVRTPESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XTP6</accession>
    <name>A0A1H5XTP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14905">
        <property type="protein sequence ID" value="SEG14905"/>
        <property type="gene ID" value="SAMN04489712_103398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG14905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="182" mass="19459" checksum="1D424438EBA68474" modified="2017-01-18" version="1">MTVPKGMGAAAPGELVLRARAGDDTAWAALTDRYSAMLWAIARGHGLGPADAADVVQLTWLRLVEHIGALRRPDRVGAWLAVTARRESARTLRHRGRSEERSLEALPDPVTPEAVLAGRERLRAVFDAIGALPGLCQQMLRLLALSPTYAEVSAALDIPVSSVGPARARCLASLRKRLEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZ98</accession>
    <name>A0A1H5XZ98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16993">
        <property type="protein sequence ID" value="SEG16993"/>
        <property type="gene ID" value="SAMN04489712_103480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG16993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="32497" checksum="0C7BFD0116F11A0B" modified="2017-01-18" version="1">MLEGMDRRELADFLRSRRARIRPEDVGLETGPRRRTSGLRREEVARLAGMSVDYYIRLEQARGPRPSRQILGALARALRLTDAERDYLHHLAGESPQPRPGPPQDVPAGILHLLDRLDDTPAFVMDAKYDVLAWNAMAAALVPGFSLLAPRDRNPLRSFFLAPESTQIIDDSEYGRFARTCVADLRAAAARYPDDPGVAGLVAELLRGSALFTRLWSEREIAVQQSNVKVLRHPVVGPIELHCDILLVPDRDQRVVLYTAAPGTPAYEALKLLRVVGTQDLTADAAVGEQGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y0F8</accession>
    <name>A0A1H5Y0F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17100">
        <property type="protein sequence ID" value="SEG17100"/>
        <property type="gene ID" value="SAMN04489712_103484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG17100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="458" mass="50400" checksum="24B54F40E2C6C667" modified="2017-01-18" version="1">MTDPTQDPLQSAARDHLWMHFTRHSSFENGGEVPVIVRGDGAYIYDDKGKRYLDGLAGLFVSQVGHGRQELAQAAAKQAAELAFFPVWSYAHPKAVELAERLAALAPGDLNRVFFTTGGGDAVESAWKLAKQYFKLTGRPTKHKVISRAIAYHGTPHGALSLTGLPGLKAPFEPLVPSAFRVPNTNIYRAPEHGDDPEAFGRWAADRIEEAIEFEGPDTVAAVFLEPVQNAGGCFPPPPGYFQRVREICDRHDVLLVSDEVICAYGRLGTMFGAQKFGYRPDIITFAKGITSGYAPLGGMLVADRLFEPFKEGTRMFAHGYTFGGHPVSAAVAMANLDLFEREDLLGHVRRNEGAFRATLEKLLDLPIVGDVRGDGFFYGIELVKDKNTKETFDDDEAERLLRGFVDKALYDAGLYCRADDRGDPVVQLAPPLICDQSHFDEIEQILRAVLSEASNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y101</accession>
    <name>A0A1H5Y101_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17613">
        <property type="protein sequence ID" value="SEG17613"/>
        <property type="gene ID" value="SAMN04489712_103503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="39"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG17613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="43838" checksum="6142B4409E2B58C8" modified="2017-01-18" version="1">MLTLGTRLKNYAFLVLGVLVIAYIGVRYADLSRYVGVRDYYVVKVDLAQTGGLYTNADVTYRGVSVGRVGPMHLNGQGLRADLHIDRSAPKIPTNLRAVVANLSAVGEQYIDLRPETGDGPYLRNGSVIPQSATATPAPVTNLLTSLNDLAASVPLESLRTVVDEFGRAFEGQGANLQALMDTSGEFIDAADVALPSTTKLIVDGETVLRTQNEQSAALRSFAANARLLADRLGTADADLRRLITTAPDAATQLTGLVRDLDPSLSVLVANLLTTSDVALTRQRGIEELMVRLPQAVAAGSTAITPRGASFGMAVTFFSPLPCVRGYEGTTYRNGLNTSPGPAFNRAASCREPASTGKNVRGSANAPYGGGVPKARKPGSTDARVAAATGLPGALALPSVQTGATDLSGLLGLTGWAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YLL0</accession>
    <name>A0A1H5YLL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureF</name>
        <name evidence="4" type="ORF">SAMN04489712_10481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25033">
        <property type="protein sequence ID" value="SEG25033"/>
        <property type="gene ID" value="SAMN04489712_10481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG25033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="22581" checksum="817101E574E863EF" modified="2017-01-18" version="1">MSPAALLVLSDGRFPSGGHAHSGGAEAAIAAGHVHDAATLERFCLGRLHTVGLVSAALAAAAAGGCDPLLLDAAADARTPVPALRRVARRMGRQLMRAVLAVWPDPGLRELAAARPGGAHQPIVLGLAARAAGLSPPDAAQAAGYDAVCGPVTAAVRLLGLDPFHATAVLARLTDDIEEVSRQAAGDAARVPAEGVDVLPAASAPLLDITAEQHSAWPVRLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YQX1</accession>
    <name>A0A1H5YQX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26503">
        <property type="protein sequence ID" value="SEG26503"/>
        <property type="gene ID" value="SAMN04489712_104137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG26503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="421" mass="45674" checksum="DF15CD08F99B014F" modified="2017-01-18" version="1">MGHVIRAYRHHPLHGPRPLSQDLVARWLNVTQAYLSRVESGPPITDLNRLISWARVLGIPSRLLWFKLPEDRQEHASINVPRPRQPSAPSPPTAVQHSTVMPLAGVTPMLGDTPDVAALYAFRAADRQVGGGHLYATVTSYLQTAIAPRLFGAQGTNNGADDFTAAGGFTEMAGWMAHDAGHDSVAGRHFHRSLDLAQMGGDAQLSAHVHASLSHLFLHLGKPRDAIHRARQGHSVLTAAPPMPALSARLLAMEARGLAALDDSAACAGALLQAEKTLERSSAEEPSPWVSPFDAGSLASEAARCMRRLGHLDEAERQARQVMELRAGGHTRSRAFAQLLLVNVLIAQGKPEEACAIAYEVLEATQALSSHLVTQQLDELRSLLEPYRTGPAVAEFLPWLEQAVHRRVGLYRWLTSGSVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YSS6</accession>
    <name>A0A1H5YSS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell fate regulator YaaT, PSP1 superfamily (Controls sporulation, competence, biofilm development)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27279">
        <property type="protein sequence ID" value="SEG27279"/>
        <property type="gene ID" value="SAMN04489712_104170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="58"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="30828" checksum="A75EF94C184F3829" modified="2017-01-18" version="1">MGMVMAVSFTRYGRLYYLDPGPHSPRVGDKVLVPTDSGPEVAECVWAPQWVSEDIDGLPVCAGLADDEHLARDEANRRRRAEGRSVAKRLIRKHGLPMKVIGVDYLDADEVFKVYFSAPHRVDFRALVRDLARTIKARVELRQVGPRDEARLQGGIGPCGRDLCCATFLKDFEPVSVRMAKEQDLPVNPLRIAGACGRLMCCLKYEHPLYVEAHQRMPRLGQRVDTPEGSGQVVARNVPADEVTVRLDGGRRCSCPSASVCSPRRQHDAAYGRPASPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YTA2</accession>
    <name>A0A1H5YTA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26546">
        <property type="protein sequence ID" value="SEG26546"/>
        <property type="gene ID" value="SAMN04489712_104139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="51"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="17475" checksum="13E3CDE0F07B7EBF" modified="2017-01-18" version="1">MGNCRTGYQSAAEWLRSPEPLRWRRTYPGRLDQVTVARRLAVSLFAGTGYEDEVGFIVTELASNAVRHSYSGHRGGWFGLEVVLDDVAYVGVTDQGGGGVPVVLPELPDEPMTEYGRGLRAVSKLAMALGIHGSGDGGHTVWADLDLCAETGTRPDLQAVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YV46</accession>
    <name>A0A1H5YV46_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_104199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27888">
        <property type="protein sequence ID" value="SEG27888"/>
        <property type="gene ID" value="SAMN04489712_104199"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG27888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="20851" checksum="9C5A8A2A92547234" modified="2017-01-18" version="1">MTSPDRTPTGSHMLVQHRTVLSLGSNLGDRLSNLQEGIDALFDAPGLRFVAMSPVYETAPYGGPEGQIPPQDDYLNVVVVADTRLAPETLLDRVLSIENSLGRVRETRWGPRTLDIDIVVFSNVTSEDPRLTLPHPRAHERAFVLVPWADVEPDVLLPGHGRVADLAAAALRAGGPDVVRRRDDLTLQEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZBB1</accession>
    <name>A0A1H5ZBB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">SAMN04489712_104432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067912209.1">
        <property type="nucleotide sequence ID" value="NZ_FNVO01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32927">
        <property type="protein sequence ID" value="SEG32927"/>
        <property type="gene ID" value="SAMN04489712_104432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG32927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="73" mass="8453" checksum="9E900387CF31B915" modified="2017-01-18" version="1">MPKKEGAIEIEGTVVESLPNAMFRVELDNGHKVLAHISGKMRMHYIRILPDDRVVVELSPYDLTRGRIVYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZEA4</accession>
    <name>A0A1H5ZEA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase DhaK subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34778">
        <property type="protein sequence ID" value="SEG34778"/>
        <property type="gene ID" value="SAMN04489712_104515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012736">
        <property type="entry name" value="DhaK_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02363">
        <property type="entry name" value="dhaK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="332" mass="34357" checksum="122B623FFEF5A13A" modified="2017-01-18" version="1">MRKIINDPVKVVADALRGLAAAHPGLRVDLEAGIVVRADAPRSGKVGLVSGGGSGHEPLHVGFVGHGMLDAACPGEVFTSPVPDQILAATAAVDGGAGVLHIVKNYTGDVLNFRLAADFAKDDEDIEVATVVVDDDVAVQDSTYTAGRRGTGATLFVEKIAGALAEEGAPLEAVAAVAREVNERTRSFGVALSPCTVPAAGRPTFELDPGEMELGIGIHGEPGRERVKAGSANEIVTAALTAIDADMPLRGSDTLVLVNGMGGTPLLEQYVAYGVASSWLADHGVTVARSLVGPYVTSLEMAGCMISVCRLTPELLRLWDAPVQTPALRWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZG74</accession>
    <name>A0A1H5ZG74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ORF">SAMN04489712_104538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35262">
        <property type="protein sequence ID" value="SEG35262"/>
        <property type="gene ID" value="SAMN04489712_104538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG35262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="345" mass="37909" checksum="F1A2EAE7245728C0" modified="2017-01-18" version="1">MSSVTAPRVLSGIQPTADSFHLGNYLGALRQWVALQDTHEAFYCVVDLHAITVEHDPQALRRRTRAAAAQLLAMGVDPERSALFVQSHVPEHAELAWVLSCLTGFGEAGRMTQFKDKSAKHGASAASVGLFTYPILMAADILLYTPEPGEGQVLQVPVGEDQRQHLELTRDLAQRFNHRFGETFVLPGAYIPQGAAKITDLQEPRVKMSKSASTPQGIVEVLEDPGPMRKKIMRAVTDTGTEIRYDEENKPGVTNLLRIHAALEGVPVAELEQRYAGQGYGQLKKDLAQLLLDTFTPIRERTERLLEDDKQLDRILADGAARAGAVAARTMEVVRERVGFVGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ACQ0</accession>
    <name>A0A1H6ACQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46152">
        <property type="protein sequence ID" value="SEG46152"/>
        <property type="gene ID" value="SAMN04489712_105347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292547" evidence="1">
        <location>
            <begin position="40"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="456" mass="48823" checksum="A205DC3F909CB30C" modified="2017-01-18" version="1">MVPHAIFRLPSAVSSARLAIGAVLLGTAGCTGSAGGHVAETVAAWSDTSVNAVSRPMSRGGVTAVTGLRPDGRLETAVYDLATGRRRWSQPAAMAGRLPGMGVQPPAVAGPARAPVVAALEPRGSGRGRATLVVRDARTGAQRWTRPVDSTFGPVRCGPQLCMSEFTTARNARFVALDSATGRTLWSMPGVAEVEASDERRAVVYRMARHPVLESRDLRTGRTLWSFPVERAVGEGVALSGGWSFTALGDTMVGYLAPYQEAKGRPLSAFGFFGLRMADGRPVWTRKRLLRVYPGASPAVSLMAREVDARGGYGGFAQLDPRTGRTIARVPADRAPRTAWWLAFPDDLSKLGFLSQNGRGTAFDLRRGAEVPARGLRAWSFCTVNPAELRIEGHRGFYPIAPLCAYDLGTGRRVADPGPPPAWYTGAVDGWRVWRDEQGVLHAVRDTTTTIPGMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AM49</accession>
    <name>A0A1H6AM49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49621">
        <property type="protein sequence ID" value="SEG49621"/>
        <property type="gene ID" value="SAMN04489712_105541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG49621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="29574" checksum="B01380C9DBA35D30" modified="2017-01-18" version="1">MTVPLGKLPGAETGDLLFDIDDHGIAHLTLNRPERGNAITVEMFPQLRAVWEEVRTNPAVRCVIITGAGSRHFCTGVDVDSVAATGKVSMGSGNITDEIVFTSRQNRVWKPVICAVNGLAAGGGLHFVVDSDIVVAVEDAAFVDTHVNVGMVGGIENTGLARRLPLGTALRMTLQGRNFRLPASRAYQLGLVDELTSEEELYGTAMRIAQDIAANSPQAVSLSQQAVWASTEMPYSHSVEYAWGLVRSHWSHPDFVEGPRAFAERRPPRWSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6APK7</accession>
    <name>A0A1H6APK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49706">
        <property type="protein sequence ID" value="SEG49706"/>
        <property type="gene ID" value="SAMN04489712_105545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG49706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="11097" checksum="BBEB4FAF1EDFA7DC" modified="2017-01-18" version="1">MPSPHPPEFRRRAVELARQGDKPLVQLAKDLGISRSCLQNRVSQADADDGQSGESGRLTSTEKKELAELRRRNRQLETENEILKRAAAYFARKNVLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B127</accession>
    <name>A0A1H6B127_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53836">
        <property type="protein sequence ID" value="SEG53836"/>
        <property type="gene ID" value="SAMN04489712_106120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="220"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG53836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="37900" checksum="1FB279897B522615" modified="2017-01-18" version="1">MSDELDLLYTDVEESVRDSVRALLAKRCTPDRVTAVYDGDRTGLDELWRALSTDLGLAGLLVPEDLGGAGASAREVSVVLEELGRFAAPVPFLTSAVVATTALLEAGAADRLGELAAGERTAALAVPLSTVPGRAVPAVTVHDGVLRGTVTAVAGALEADLLLVPVQGDGGLELHEVPADAARITPVTSLDMTRQIADVELAGAASRPVADAGAAERAIGRALETGAALLASEQLGVAQWCLDSTVEYLKIRRQFGRIVGGFQALKHRLADLYVAVESARAAARYAAAAVAADDPDRSVAASVAQAYCADAAVLAAEECVQLHGGVGMTWEHPAHLYLKRAKADQLAFGTPGAHRARLAGLVDLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B1M1</accession>
    <name>A0A1H6B1M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54728">
        <property type="protein sequence ID" value="SEG54728"/>
        <property type="gene ID" value="SAMN04489712_106175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG54728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="25133" checksum="C2DF9EB211D33343" modified="2017-01-18" version="1">MGPHAHGWWILLHLVLFVFWLGGDLGVFYSSRYVLKPDLAPAARAATLGVMSGLDLGPKICLVLFLPSGVTLMALEPHGAELFGAPAFGWWQVSLVWLFALAWLAATVADHRTHGRFPWVRRADWAVRIGLIAVLGTVAAYTMLADRPFGVTTDPRWLGAKVALYTAAIACGLGIRLTLRPFGPAFGALMSGGSTPEVERALKRSVDGCLPYVYGIWAAVLSAAALGVLKPGADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BFS4</accession>
    <name>A0A1H6BFS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized membrane protein, DUF485 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59167">
        <property type="protein sequence ID" value="SEG59167"/>
        <property type="gene ID" value="SAMN04489712_10751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG59167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="18338" checksum="910939193725602B" modified="2017-01-18" version="1">MPFARSSYGIDRSPMAADGSAQAPGGSAQPARGPLHVAVPAFYLGVTPVTAEEDHVTVEKDLDRGGTPYERVQRSPEFQELRRRFRAFVFPATVAFLTWYLLYVVLSGWARGFMGTQIVGFINVALIFGLLQFVSTFLIAWLYARHAEAKLDPMAAELGARVEGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BMK7</accession>
    <name>A0A1H6BMK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal recognition particle receptor subunit beta, a GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61913">
        <property type="protein sequence ID" value="SEG61913"/>
        <property type="gene ID" value="SAMN04489712_107256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG61913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="21103" checksum="0BDB36CAAC212DEB" modified="2017-01-18" version="1">MSFARSDDGPRIALKILVAGGFGVGKTTLVGSVSEIRPLRTEEFLTDASVGVDDTRGVEAKTTTTVAMDFGRITMRDGVVLYLFGTPGQDRFWFMWNELARGALGAVVLADTRRLTASFASIDYFEQRDIPFVVAVNCFEGAHRYSLEEIRDALDVDPQVPVVTCDARDRESAKHVLISLIEHAVQHSVPAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUC6</accession>
    <name>A0A1H6BUC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64269">
        <property type="protein sequence ID" value="SEG64269"/>
        <property type="gene ID" value="SAMN04489712_1089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
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        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294106" evidence="1">
        <location>
            <begin position="31"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="41"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG64269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="39400" checksum="5327F6E24890339D" modified="2017-01-18" version="1">MNRWRRAALAGTAAALACGMVTAVPGTAAADRGRDRQRGAFDLQAHRGGLGLVAESTLPAFANALELGVRTLELDVQITEDRRAVVTHDRQVSPRKCRDTAPVTPGDPEFPYVGKYVHTLTLAQVRTMDCGSQTLPEFPGQRAVPGARMPLLREVFGLVHRYRAYGVRLNVETKVEAGAPHETAPREQFVQVTAEEIRKARLLRQVTIQSFDWGALMRMRRVEPRLPLVALTNYDFLQTGRPGASPWLGGLDIDDFGGDPLTAVRSFGAAAFSPVHGFPQNGKVTDPGYRPYVTAEMVRRAHRMGLKVIPWTVDDKPTMRKLIDDGVDGIITDYPDALREVMAERGLRLPKRYRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUF5</accession>
    <name>A0A1H6BUF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative peptidoglycan lipid II flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64371">
        <property type="protein sequence ID" value="SEG64371"/>
        <property type="gene ID" value="SAMN04489712_10818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG64371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="532" mass="53400" checksum="FEDA0BDD094B8797" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BWQ6</accession>
    <name>A0A1H6BWQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_10880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65139">
        <property type="protein sequence ID" value="SEG65139"/>
        <property type="gene ID" value="SAMN04489712_10880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG65139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="708" mass="76452" checksum="81AACA88CCDBB871" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZ70</accession>
    <name>A0A1H6BZ70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66009">
        <property type="protein sequence ID" value="SEG66009"/>
        <property type="gene ID" value="SAMN04489712_108157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="110"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="28493" checksum="57CA33FBEFA0A2DE" modified="2017-01-18" version="1">MTSHEPMTGRDRDAVAAAAARLQAAQDGRTPCAPVRDLLGTSDLALAYAVQRRLAEHRLAAGARVVGRKIGLTSPAVQRQLGVDQPDFGMLFADMDVSALPEVPAERLLQPKAEAEVAFVLGADLDHEISGVDDVRAAVAYAVAALEIVDSRIADWDITITDTIADNGSSALYVLGDRRLTLEEFEPVEVVMRLYADGELVSEGDGAACLGDPLRALAWLARTAREFGEPLRAGQVVLSGALGPMVPVAPGSVVRAELSRLGSVTAVFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C155</accession>
    <name>A0A1H6C155_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA ATPase forming ring-shaped complexes</fullName>
            <shortName evidence="2">ARC</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arc</name>
        <name evidence="5" type="ORF">SAMN04489712_108212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer. Assembles into a hexameric ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66662">
        <property type="protein sequence ID" value="SEG66662"/>
        <property type="gene ID" value="SAMN04489712_108212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02112">
        <property type="entry name" value="ARC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041626">
        <property type="entry name" value="Prot_ATP_ID_OB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022482">
        <property type="entry name" value="Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17758">
        <property type="entry name" value="Prot_ATP_OB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03689">
        <property type="entry name" value="pup_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="265"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="276"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG66662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="587" mass="65100" checksum="A9033CD587411067" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9F8</accession>
    <name>A0A1H6C9F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69006">
        <property type="protein sequence ID" value="SEG69006"/>
        <property type="gene ID" value="SAMN04489712_10940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="26479" checksum="77FFF52D56EEAA1B" modified="2017-01-18" version="1">MSGLLEGRVVLVTAAAGAGLGYATAKRCAEEGARVVISDMHERRLAEAAERLTEVMGDKPAAIGCDVRDTAQVDALIEAAVRAEGRIDVLVNNAGLGGDRPVVEMTDAEWDRVVDVSLTSVFRATRAALRHMLPRRSGVIVNMASVSGWRAQVNQAHYAAAKAGVMAFTRCVALEAAPAGVRVNAVAPSLAMHPFLEKTVSRELLEELTSREAFGRAATPEEVANVVVFLASDLSSYMTGEVVSVSNQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CA79</accession>
    <name>A0A1H6CA79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69812">
        <property type="protein sequence ID" value="SEG69812"/>
        <property type="gene ID" value="SAMN04489712_109117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="84"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="30793" checksum="7AD20C2556165C06" modified="2017-01-18" version="1">MDTPAKGCLDYGAAAESPQVPGVDGFGELLRDCYRAGARRGVARQVIERSDGFVSVEDAFRYFTRPDEWMVPERRAVELAAGRVLDVGCGAGRHMIAMRNCQEVVGIDPSPGAVEVARSRGLDARLGTVQRPGDLGTFDTIMLLGGNLGLLGSREQAPKVLGSLARLARPGARMYAIGRDPYAVRPPEHLRYHDTNRKAGRMPGQVRMRLRYRCWASAWFDRLMVSPYELEMLVTGSPWRLLDCSAVYATGFFLAELQHVGTQRAITDAPATTPPQRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCM5</accession>
    <name>A0A1H6CCM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70770">
        <property type="protein sequence ID" value="SEG70770"/>
        <property type="gene ID" value="SAMN04489712_109202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294794" evidence="2">
        <location>
            <begin position="33"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG70770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="134" mass="14874" checksum="591E96631807C9C3" modified="2017-01-18" version="1">MSREGSRKGLRRSLPGAGLVLVLALTAVPAAADTAEPSPADQQGAKWLCQRVDRAEQRLDKLIGVFSGGPQTRGSVAELRARADRMQERRPERAARLDKRADRREQRIGKLKQHRQGLAKAKQWCLSQGFPTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEH5</accession>
    <name>A0A1H6CEH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Selenocysteine lyase/Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_109236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71055">
        <property type="protein sequence ID" value="SEG71055"/>
        <property type="gene ID" value="SAMN04489712_109236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="19"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG71055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="41908" checksum="AE995C49A61B3A78" modified="2017-01-18" version="1">MDLDRIRAQTPGCQNVVHLNNAGAALPPAVVHDTVLGHLELESRIGGYEAADAAAEAFTASYDVLARLVGAHPDEIAFVENATRAWDMAFYAIPFRAGERILTTSSEYASNALGFLQAAQRHGAVVEVVPDDGHGQICLDSLARMLDAGNVRLVAINHVPTHDGLVNPAAEVGKLAREAGALYLLDACQSVGQLVVDVAEIGCDLLSATGRKFLRGPRGTGFLYARREVAQQLVPPFVDLRAADWTGPDSYELRPDARRFETWERFAAGQLGLAAAASYALGLGLEAIQERVTGLGERLRAALAELPGVTVHDQGLRKSGIVTFTHETVGAPEIVARLAAAPRPVNVRVTEQTYRYDAGARPPLRVRISPHYYNTEEELDLAVSAVAAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKH8</accession>
    <name>A0A1H6CKH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside 6'-N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73499">
        <property type="protein sequence ID" value="SEG73499"/>
        <property type="gene ID" value="SAMN04489712_110117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="168" mass="18924" checksum="C314FF1C7847495C" modified="2017-01-18" version="1">MIELAGRDVVLVPVAEEHVAELKRIRRTPNVRHRWGDVDGEPDWPFDDPGTVPYTILLDGAVCGLVQYGEQDDPQYRHASIDIFLDPAVHGRGVGRDAVRTLARHLIRDRGHHRLVIDPAADNEPAIRCYTAVGFRPVGLMRNYERDTDGKGWHDGLLMDLIAEEFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CL59</accession>
    <name>A0A1H6CL59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73176">
        <property type="protein sequence ID" value="SEG73176"/>
        <property type="gene ID" value="SAMN04489712_11080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="458"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG73176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="714" mass="73569" checksum="41B87498D8ABB62E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM97</accession>
    <name>A0A1H6CM97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74091">
        <property type="protein sequence ID" value="SEG74091"/>
        <property type="gene ID" value="SAMN04489712_110188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="842"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG74091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="904" mass="96354" checksum="8582C5EBF992F466" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQW8</accession>
    <name>A0A1H6CQW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase (GNAT) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75238">
        <property type="protein sequence ID" value="SEG75238"/>
        <property type="gene ID" value="SAMN04489712_1112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="153" mass="16302" checksum="D8044A7356536C34" modified="2017-01-18" version="1">MNVRLACGQDVPGFLDLAGQVEHWFGPMVQDPGFHAAVDKHISRATALVAVDGANVVGGLLFGAEPPTYHVHWLVVCEQARGQGVGRALMADVMGRFVQRPATVEVVTFGADHPGAEESGARVFYERLGFVPAEPAPPGPEGGSRQVYRKNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSU1</accession>
    <name>A0A1H6CSU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75847">
        <property type="protein sequence ID" value="SEG75847"/>
        <property type="gene ID" value="SAMN04489712_11190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="366" mass="39507" checksum="C532876026C75B11" modified="2017-01-18" version="1">MSKSGQLATADVVVIGGGQAGLAAGYYLRRAGLDFVILDAQDGPGGAWRHVWPSLRLFSPAQHSSLPGRPMPATREPYPSAAHVVDYLADYEKRYALPVHRPVRVHHVHRDGPGLRVDTDRGTWHAAHVISATGTWWQPYLPHYPGRALYQGQQLHTVHYRGPAPFQGQRVVIVGGGNSAAQILADLTDPALGRGGSAAEAVWVTRRPPRLLPDHIDGRALFTLAARRRADLHAGRADTGGVGGLGDIVAVPPVRAARDRGALQARPMFTRLTETGIGWDDGPRIDCEAIIWCTGFRPALRHLSPLRLRTDDGAIPLTGTRAHGEPRLHLIGYGDWTGLASATLIGAGMNARDAVRALTSHPRQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTX3</accession>
    <name>A0A1H6CTX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75856">
        <property type="protein sequence ID" value="SEG75856"/>
        <property type="gene ID" value="SAMN04489712_11191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="12989" checksum="8097B6226A027C4D" modified="2017-01-18" version="1">MGDLGTVLSHQLFRALGDPTRVRLLDLLAERCRACSVSELADCMDLDLSVVSRHLALLRAAGVLRATKTGRNVLYEIQFDALAEALRGIADALERARDDFESAGSCSPANQEADQEEGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CWA4</accession>
    <name>A0A1H6CWA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_111234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76993">
        <property type="protein sequence ID" value="SEG76993"/>
        <property type="gene ID" value="SAMN04489712_111234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG76993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="512" mass="53772" checksum="1ED857B2236AE93F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CWK4</accession>
    <name>A0A1H6CWK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77228">
        <property type="protein sequence ID" value="SEG77228"/>
        <property type="gene ID" value="SAMN04489712_111267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24772" checksum="335EC3973DD455D9" modified="2017-01-18" version="1">MRIVAVADTHTYHHELVVPEGDVFVHAGDLCRRGKSLEELRNAADWLYALPHRVKIVVAGNHDWMFLDEPERARAVLADRGIRYLQDSGTEIDGVTFWGSPWQPEFNEWAFNLPRGRLLAEKWALIPENVDVLVTHGPPLGIGDTNAVPGRHGCADLLARVRQVRPRLHLFGHIHQDGGLWHRDGTCFANVTTWECERGPTVIQLEPSGAVGEIVPPARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZL0</accession>
    <name>A0A1H6CZL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_112100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024936225.1">
        <property type="nucleotide sequence ID" value="NZ_FNVO01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78609">
        <property type="protein sequence ID" value="SEG78609"/>
        <property type="gene ID" value="SAMN04489712_112100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG78609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7207" checksum="E78552892010A434" modified="2017-01-18" version="1">MATGTVKWFNAEKGFGFIEQDGGGADVFAHYSNIAAQGFRELQEGQKVSFDITQGQKGLQAENIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZV1</accession>
    <name>A0A1H6CZV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Isopalmitoylresorcinol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78304">
        <property type="protein sequence ID" value="SEG78304"/>
        <property type="gene ID" value="SAMN04489712_11260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="4">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="5">
        <location>
            <begin position="237"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG78304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="373" mass="38461" checksum="B59198E09B4CE1A0" modified="2017-01-18" version="1">MTSSGRRDLSAAPGRATGPGHATTIAAVHTALPPHRYTQDQITELIGDLSLAPCDDRALLRRVHTAAGVRTRHLALPIERYAGLGDFGQSNDAWIAAGLDLGEEALTGALTAAGRTPAEVDLLVCVSITGVAAPSLDARLAGRLGLRPDVKRLPVFGLGCVAGAAGLARLHDYLRGHPGDVAVLLSVELCSLTLQRRDGSMANLVAGALFGDGAAAVVAYGADAGRDDAGPAVVATRSRLYPDTERLLGWDVGATGFRVVIGAGIPAVVRAHLGREVHGFLAGHGLTVGDIGTWVCHPGGPKVISAVADALDLPDDALDATRRSLAAVGNLSSASVLHVLQSTWESERPAPGTWGLLMAMGPGFSSELVLLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D116</accession>
    <name>A0A1H6D116_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78992">
        <property type="protein sequence ID" value="SEG78992"/>
        <property type="gene ID" value="SAMN04489712_112151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="11207" checksum="DC5EFDD377B27173" modified="2017-01-18" version="1">MSRSTQPPAPMTDGEAVSSTDPRRAALQALAGLLRGRGLAVTVESWHLTATDHDSGRSVEVWAQHRSADQDRLWFCWAGGAPIVEAANLMDAALYVGTELCRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D556</accession>
    <name>A0A1H6D556_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80108">
        <property type="protein sequence ID" value="SEG80108"/>
        <property type="gene ID" value="SAMN04489712_11315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="100"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="472" mass="51519" checksum="A14CED74D98FC8E9" modified="2017-01-18" version="1">MTEPIGPDGSDIRVEGGGGLTSLSTAAARNLASTTKSVPQMQNITSRWLLRLLPWVQVSAGTYRVNRRLTYVLGDGRVSFTNVGAEVRVIPAELGEIPVLRGYGDAAVLEALAERFEQHEYQSGEVIAEAGHEVDRLLLIAHGKVNRIGSGKYGEENVLGVLADGDHLGDQALQEEPGTWDFTVRAATACTVLALPADSFRTVLERSDSLRDHLDSARPADAAATNRYGEAEISLASGHSGEPVLAGTYVDYELSPREYELSVAQTVLRVHTRVADLYNQPMNQVEQQLRLTVEALRERQEHELINNRDFGLLHNADLKQRIHTRTGPPTPDDLDELLSRRRGSRYFFAHPRAIAAFGRQCNARGLYPGSAEVNGQSVPAWRGVPILPCNKIPISDQGTSSIIVMRTGEEEQGVIGLNQTGLPDEYEPGLSVRFMGIDDQAVIKYLVSTYFSAAVLVPDALGVLENVEVFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5N0</accession>
    <name>A0A1H6D5N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_113131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80687">
        <property type="protein sequence ID" value="SEG80687"/>
        <property type="gene ID" value="SAMN04489712_113131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="21168" checksum="0A622A33F02A8E58" modified="2017-01-18" version="1">MKAPVVHQHPQLHARVCSVLNAALRADNTAIDTVVQLAEGLDAHTADFLRHSRRLVLACAAALSSVLDIHQPVTEPDAPRVCRECGGHQCRTLNNILNVLDAYAARPGEIDRAEAWRRADHYFNARGGPTSLVAVDTFEDGYVARAFTTTTTAEPAGPLLVIDRRTGRLSAWPPMPRQTLIEQYRRYLDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D684</accession>
    <name>A0A1H6D684_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_113109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80594">
        <property type="protein sequence ID" value="SEG80594"/>
        <property type="gene ID" value="SAMN04489712_113109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="29518" checksum="EFB0E4C83ED54D82" modified="2017-01-18" version="1">MTADEQEHAPAGIDVSQPSFARVYDYFLGGKDNYAADRQVADMVMELVPEAPVVARGNRIAIDRAVRYLAGEVGIDQFIDIGSGLPTASNVHESAKDVNPGVHVVYVDNDPIVLAHGRALLTENGVATVIQGDLYEPEKIFTDPALTGLIDLSRPVGIILAAIIHHVPDERDPRAVVRRLHDFVAPGSHFALTHLHDSGDDPRVEEAKKILQSGLGGSYFRRREQIEGFLDGLTLLEPGVVNVTEWRPNGPAGPLEHPLHSQMVAAMARKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6Y9</accession>
    <name>A0A1H6D6Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80515">
        <property type="protein sequence ID" value="SEG80515"/>
        <property type="gene ID" value="SAMN04489712_11396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG80515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="32389" checksum="0AE6477E0F74E3E9" modified="2017-01-18" version="1">MTTVPLEGLPERVTIYEVGPRDGLQNEKTIVPVADKAEFIARLAAAGLRTVEATSFVHPTWVPQLADAEELLAAMDRTEGVRYPVLVPNERGLDRALASGITEIAVFASATESFARRNLNRTVDESLEMFAPVVGRARERGMWVRAYVSMAFGDPWEGDVPIEQVVSVAVRLVELGCSQISLGDTIGVGTPGHVTALIGALAEAGVGTDRLAVHFHDTYGQALANTLAALRCGVSTVDSSAGGIGGCPYADSATGNLATEDLVWMLHGLGVETGVDLPALAETSRWMAARLGRPSPSRVVQALTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D926</accession>
    <name>A0A1H6D926_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent ferric siderophore reductase, contains FAD-binding and SIP domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81851">
        <property type="protein sequence ID" value="SEG81851"/>
        <property type="gene ID" value="SAMN04489712_114158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="27600" checksum="7107F33C7EB50378" modified="2017-01-18" version="1">MPKRTRNPLAGAFAKYRLETTVTAAEAVTPTMRRIRLVADEPIGFPYVPGQHVRVELNDPLSVSGLLRPGETLRTYTIWELDPGERAIELRAHLYDGDGIGLRWARAAAPGDRVPIWWPQGDLFTRDAPFHLFAGEETASAAFGPMLRALGPKARVYGALESESPEHDLPMPGPHRLHRVHRHGAPAHSSATLAAAVAELDLPAGDGAAYLAGEARTCQMIRDHLVRDRGWERRSIKVKPFWTPGKRGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCF6</accession>
    <name>A0A1H6DCF6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="6" type="ORF">SAMN04489712_115114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019631633.1">
        <property type="nucleotide sequence ID" value="NZ_FNVO01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82958">
        <property type="protein sequence ID" value="SEG82958"/>
        <property type="gene ID" value="SAMN04489712_115114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG82958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="78" mass="8953" checksum="A6666BB23A1E2109" modified="2017-01-18" version="1">MAKPPPRKPKKKVCVFCQEKISYVDYKDTGLLRKFISDRGKIRARRVTGNCTQHQRDVATAIKNAREMALLPYTSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEE3</accession>
    <name>A0A1H6DEE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83620">
        <property type="protein sequence ID" value="SEG83620"/>
        <property type="gene ID" value="SAMN04489712_11637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Dimerisation2" evidence="4">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="140"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG83620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="352" mass="38408" checksum="B002235D1FF9EC64" modified="2017-01-18" version="1">MADRPDQRPPAGADLVPILFGHNAFQQLNAGCELGLFDLLAEQGPLAAAAVADALGLGRRAADILLLGTTALRLTLVEDGRYRNGPAVETAFADGTWPVLRDIVEFQARVSYAPAADYAESLRTGENVGIRRFPGDSRDLYSRLSNVPGLEELFYRCMNSWSRLSNPVLVEEVDYAKTGRVLDVGGGDAVNALALARAHPHLEITVLDRPGALEVARRNIDAAGLAGRVGTHAADIFDDDYPRGHDCVLFAHQLVIWSPEQNRRLLRKAHDAVEPGGRVLVFNAFCDDDGSGPLYAALDNVYFATLPFRDSTIYRWCEHEEWLRDAGFTDLHRITGAGWTPHGVIEGLRGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DES1</accession>
    <name>A0A1H6DES1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted metal-dependent hydrolase, TIM-barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83888">
        <property type="protein sequence ID" value="SEG83888"/>
        <property type="gene ID" value="SAMN04489712_11693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="79"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="401" mass="45704" checksum="92AE063E4B324FFC" modified="2017-01-18" version="1">MADQDTAGTALCERYAVADVDSHIIEPADLWTSRVSTSKWGDLVPHVRFHERRQEDVWYIGDRKLYGVGAFAQAGWPEFPPSHPRRLSEALPAAVDPKERLTYLDQVGVYYQVLYPNIVGFHSHRFLNQMPRELATECVRAYNDWITEFCSADPRRLVAMTMLPFWDIDESVAEMRRCHEMGHKGVLFAARYDKVGLPRLIDDHWEPLLGQAQEMGLSMNFHVGFLATDEDLKGAVDQSKKIDFTRESSLVLLGNAQNIAEVVLSGVCHRYPDLKFVSVENGAGWLPFFGETMDWQWLNVGAHKEYPDRLLPSEYMRRQIYGMFWFERQSVRSVIDQLADNLMFETDFPHATSLSPGPASESPSPREVMELSLGGLPEETIGKVLQHTATKLYNLEPPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEW0</accession>
    <name>A0A1H6DEW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipoprotein-anchoring transpeptidase ErfK/SrfK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_116113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83967">
        <property type="protein sequence ID" value="SEG83967"/>
        <property type="gene ID" value="SAMN04489712_116113"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295907" evidence="4">
        <location>
            <begin position="23"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="61"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="248"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG83967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="413" mass="43897" checksum="35D6F8A1C32C4008" modified="2017-01-18" version="1">MLLRGVGAAGVTGAVVLLAATACSGGDDGGTGTGSTVAGQEDASAPQVTITPATGTNRALPDRGVVVKAGNGTLEQVTVTAKGKPVDGRMSADKTTWQSRTLIPGASYEVSAIARNPKGKTTTATSSFRTVRAAAPLTVVDMIPMPGEKVGVGMPITLTFNRSIADRDKKAVEQALRVKSTKPATGAWFWVSDRQVIFRTKNGAYWEPNQTVAVRADLAGVRAGKGVYGTADFGRKFRIGDSHISIASAKTKKMIVKVNGKTVKKTGISAGKGGRVVNGVDTYLTTSGIHLTMSKHRVERMTSAWMGVDPKDKANGGYDLMLPHAVRISSTGEYVHAAPDRYWAFGRTNASHGCVNAPPPFAEWFYNLSYRGDIVIVTGTKRSLPWNNGWSYYEMPWAKWVKGSALDREVTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF23</accession>
    <name>A0A1H6DF23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83662">
        <property type="protein sequence ID" value="SEG83662"/>
        <property type="gene ID" value="SAMN04489712_11644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="521"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG83662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="605" mass="63996" checksum="DA7E869ED5DE7B11" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFK4</accession>
    <name>A0A1H6DFK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein, DUF2252 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83523">
        <property type="protein sequence ID" value="SEG83523"/>
        <property type="gene ID" value="SAMN04489712_11612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="467" mass="52598" checksum="64CF1C8BB8F5851E" modified="2017-01-18" version="1">MTWHVPGGAGHDEWEERIIVSIIESLRRREPGQRQGQIVDVLVEAFAELMERSPAEFRRRFRKMASDPFAFYRGSACLYYADIVDDDDPWADERTSRVWIQGDLHAQNFGTYMNDDGVFVFDVNDFDEAYVGHFTWDIKRLVASVALLAWTKAISDADIRRMIETYVRAYVDQVRHFHTHHGDSGWALTLDTAEGYVREVLIAALASTRIALLEGKTLVEQHERRFKSGPGVRRLDEAERASVEKAFEDYLDTIPQEKRFSSITYRIKDIIGSSGFGIGSAGLAAYNILVEGRSQALENDVILSMKQGNVAAPSRVVDDPRIRAFFRHHGHRTAVSRRALQANTDPWLGHTEIDGVGYVVQELSPYEEDLDWSGLTEPAEMLPVLADLGRATAKIHCVSDSDSDHELVGFQVEDAIMEVIGRTGEDAFVEAMVDFGTGYAAIVRDDHRLFVDAFRSRQGPLGILWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DH85</accession>
    <name>A0A1H6DH85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84541">
        <property type="protein sequence ID" value="SEG84541"/>
        <property type="gene ID" value="SAMN04489712_11722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG84541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="34402" checksum="ECC5A5B3C6A6B365" modified="2017-01-18" version="1">MPNPPSGPAISVTGLRKSYGDKVVLDGVDLRVAEGTVFSLLGPNGAGKTTMVQILSTLIRADGGRVRVAGHDPARDPDAVRAAIGVTGQYSAVDRFLTGEENLILMADLHHLGRAQGRRRTAELLERFDLTEAASKPAATYSGGMRRRLDLAMTLVGDPRIIFLDEPTTGLDPRSRRTVWRIVRDLVAGGVTVFLTTQYLEEADELADRIALLDHGRLIAEGTADELKRLVPGGHIRLRFADAGGLESALRALGEGYLDEDALTLQVPSDGSVRSLRGLLTRLDDRSIEIDELSVHTPDLDDVFLALTGRPDDKESVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKG3</accession>
    <name>A0A1H6DKG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85611">
        <property type="protein sequence ID" value="SEG85611"/>
        <property type="gene ID" value="SAMN04489712_11845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="38145" checksum="F9D3938814BB7652" modified="2017-01-18" version="1">MNVRPLSRDREDPGRFEADARFAVEAARWAPSVHNTQPWRFGIGDRRISLRADNERRLDCTDPSGREMMISCGAALFTLTLALRQLGYAPRVRLLPAPDRPCLLADVDVDVPAAAPETVNPEVARLYEQIRERHTHRGAFRPGQVTAGLPALLQVEARREGVTLRVITDTHAQATLGALTGAAEHLGRADPGIGAELFRWAPAPGDRRENGVHPDTYPRRAERTEPDFPGRDFARGQGWGTDAPADEPAEQPSAGMVVLLTTPQDTPADWLRAGQALQRVLLRAQAEEGVSAAFHTQALEVPELRGLIRTRLCDGDHPQMLMRLGVAGTRRKSVRRPVHAVVHDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKQ5</accession>
    <name>A0A1H6DKQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85818">
        <property type="protein sequence ID" value="SEG85818"/>
        <property type="gene ID" value="SAMN04489712_11885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="257" mass="27114" checksum="1710D4FCA0D2C46C" modified="2017-01-18" version="1">MDGVRKTAVVTGASSGIGAATAWRLAAEGFHVVLAARRRDRLDALAKRIGEEVPGAGRLAAVTLDVTSQESVDELAAGLPECHVLVNNAGGAVGMEPVAEADPADWQAMYDSNVLGLLRVTKALLPKMIASGAGHVVNITSLAAHVPYEGGAGYNAAKHAAAAVNEVMRLELVAQPVRITEIAPGMVHTEEFSLVRFRGDAERAARTYEGVPEPLVAEDVADCVAWAVTRPAHVNIDRIDVQPRVQAAPYKIHREPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DM55</accession>
    <name>A0A1H6DM55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, luciferase family (Includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86288">
        <property type="protein sequence ID" value="SEG86288"/>
        <property type="gene ID" value="SAMN04489712_11943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="36516" checksum="FE726B85AD196755" modified="2017-01-18" version="1">MKISAFLSAQFDPSASAVEGLDDVLRQAVAAEEAGFHAVYLGHHYLAKSAFLQPVPLAGYLAGATTRIRIGFGVLLAPLLNPIALAEDLATLDVLTNGRLTVGIGAGYRKRETAAFGVEWGDRLRRLREYVPALRSLWNGERIDLAGSWGAVAGASLPLKPVQAGGPPIWVGAFAEPAVRRAARLDTSWLIGPKGNDEDLAAMLTIYRDTLSEHGFSLDREYPMAREAFVADTRAVAIAGVRPHMERQYAGYKSWEDAQTLDIDRYMAEDCLVGTADDIIAKLRRWETELGITEVSLRLQFVGGGQEGTLEQIRRFGAEIIPRLDAAAQGPTGGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMX1</accession>
    <name>A0A1H6DMX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86501">
        <property type="protein sequence ID" value="SEG86501"/>
        <property type="gene ID" value="SAMN04489712_11997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="85" mass="8708" checksum="C13845F97947EA9C" modified="2017-01-18" version="1">MRNWSADNGESAAGLGQPAVPEYCRCTLADRVVSFFRSPPGKAVGALASVGRAVMQRFISGAQSMAGALVNAVLGPIRNATNAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNI5</accession>
    <name>A0A1H6DNI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86323">
        <property type="protein sequence ID" value="SEG86323"/>
        <property type="gene ID" value="SAMN04489712_11953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="264"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="41067" checksum="C12EF7294C1FF17D" modified="2017-01-18" version="1">MTTSRMAHDVAIVAMGCTPFRDHWNSSADDLVVDAVDDCLKSLPGLSVGDIDAFWVGTQGTGLSGQVLARPLRLVGKPVTRVENYCATGSEAFRNAVFGVASGAYDVVMATGVEKLKDSSQSGLSAVLPPSDGTDIDWTAPAGFSLLGPAYQAAYGVGDRDMRSALTRVAVKNHANGALNERAQFRRPVTAEAVESAPRIAGQLGVLDCSGVSDGAAAAVIVRAEDAFDYTDKPVFLRGMSFVAGSGAGLATGGYDFTTFPEVVAAAEQAYTQAGVTDPATEISLAEVHDCFTPTEVVLMEDLGFSERGKAWRDILDGRYDLDGALPVNTDGGLKSFGHPIGATGLRMMFECFTQLRGEAGARQVPDAELAVVQNLGGQPGSSVAFVAVLGSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUY6</accession>
    <name>A0A1H6DUY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89070">
        <property type="protein sequence ID" value="SEG89070"/>
        <property type="gene ID" value="SAMN04489712_12314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="228" mass="24743" checksum="673DC47FA5876BD8" modified="2017-01-18" version="1">MTKVLTVADMTLREILRRRAVLVIIAMMPLAFYLSRRGDHLGQSIRFVCLGLGWALSTAALFTGGAARGLEPRLRLSGYRAHQLYLGRLVALWAAGGLLSAPYFLLILVDQDGVSHGAIALIMVLTVAVAAPFGLALSALLPRELEGTLLLLTVVGLQMIMDPADASSRLLPFWFSREIATYAVDHTDTSYLARGLVHGAVCALVLTALVALLSATRLRRRPHLRFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVN0</accession>
    <name>A0A1H6DVN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89249">
        <property type="protein sequence ID" value="SEG89249"/>
        <property type="gene ID" value="SAMN04489712_12350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="21833" checksum="FE4E850A0F61E65E" modified="2017-01-18" version="1">MAWSVALACASAGPPAAVFGPGLRSDPAAAARVAHGLYPAAGLVETGDTVLDFALWPYEDELFVGAYDRALLVCDRRLFCMDEDARRIADTVGTALPGGQGGVLVLHSVISGCWFRRYAGGALVRDVFVTAEDGVVIDRGERLPVEQPYWKAIDTGAGDVPLPFDQESFGLDLAQAYMFGRGIADRGEDGFLPLELPLRRFKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVT0</accession>
    <name>A0A1H6DVT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88853">
        <property type="protein sequence ID" value="SEG88853"/>
        <property type="gene ID" value="SAMN04489712_12293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG88853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="547" mass="59209" checksum="C51BA5C16252236A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWS7</accession>
    <name>A0A1H6DWS7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrS</name>
        <name evidence="13" type="ORF">SAMN04489712_12336</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89173">
        <property type="protein sequence ID" value="SEG89173"/>
        <property type="gene ID" value="SAMN04489712_12336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="294"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG89173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="656" mass="73488" checksum="7F025ABC3159EBB2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXW4</accession>
    <name>A0A1H6DXW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ORF">SAMN04489712_12390</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89425">
        <property type="protein sequence ID" value="SEG89425"/>
        <property type="gene ID" value="SAMN04489712_12390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="42"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="403"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="726"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SEG89425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="821" mass="88071" checksum="916779E33C09F5D8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYT2</accession>
    <name>A0A1H6DYT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90487">
        <property type="protein sequence ID" value="SEG90487"/>
        <property type="gene ID" value="SAMN04489712_12653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="154" mass="17551" checksum="EAD2D5CBCEC6BCD4" modified="2017-01-18" version="1">MLEPEVISREEIRSLLIEYVHCADGGRTDRMLELFAEDAVMEPTGDPVCRGRDEIRAYFESAGRSIRRHMAAPTLRHHLSSIHIELTSATQARTTAYFLAVTEIGPDHWGRYRDTLRKTGDSWQITHRLLQLEGRTPGGWLDRHEAARGTEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZZ9</accession>
    <name>A0A1H6DZZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90902">
        <property type="protein sequence ID" value="SEG90902"/>
        <property type="gene ID" value="SAMN04489712_12773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="37403" checksum="5A65C0913B8DF03A" modified="2017-01-18" version="1">MAGECENRRAIDRMSPHMPISPLPPPAVVWAESPLQLLSAVEAQHAGLLGDGTEVALRAGSQSLAATAEEVLRLGMPPGLCPPAPASRVARPPRDGRWVIGDAFSGAVQRRLLSSGGRRLLVVDDGLATIHLLELLTAPAPRPLARARARLGVPRRALGLAAAARLRAAARAGALTVFTALPIPAELHAAVEALGARLVCHDFPWLRGRPAAPPPSQRLVVLGSSLVHNGLVHRRPYLEWVLALADTEPLAYRPHRRECPEVLAELRRHPRIMVAEPTGVPVEISLRGLTAEHWVVSLPSTALTSLRLVLRAAGTTIEGVPVPADWWTADADPELRAHLSLFVGGGLEIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0C8</accession>
    <name>A0A1H6E0C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90911">
        <property type="protein sequence ID" value="SEG90911"/>
        <property type="gene ID" value="SAMN04489712_12776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="27257" checksum="AEB510023242FD91" modified="2017-01-18" version="1" fragment="single">GLAASSGRLITYLDGDDWIAPGYLAAAVEAIDAIGCDFIKTDHIQVYGKRREVHRAPQGRRGVKLVPRDGILPAHVQTMADYPNAWSGVYRRELAADGLLTFDEELLTCEDRPWAWKLLLHAASYAVVSLFGVFYRREVAGSLTKIGDERQLHFFDAFDKVLAELAGDRDGDRFVGKAAQTYCAMIAHHLAERDRLTPDLQQRLRQRARATLKALPPDVVTELRPRLSRERQELFATTLGIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E248</accession>
    <name>A0A1H6E248_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_13022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91690">
        <property type="protein sequence ID" value="SEG91690"/>
        <property type="gene ID" value="SAMN04489712_13022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296430" evidence="4">
        <location>
            <begin position="35"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="6">
        <location>
            <begin position="367"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG91690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="668" mass="72345" checksum="9CFFE45C76B141D6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3R0</accession>
    <name>A0A1H6E3R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91919">
        <property type="protein sequence ID" value="SEG91919"/>
        <property type="gene ID" value="SAMN04489712_13128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="18"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="480" mass="49682" checksum="D3FB53EA6CCE012E" modified="2017-01-18" version="1">MKLFTGSYIGGRWRLSGDGSAVRVDDPATGEPLAEIASATVGDCLEAVEAAAEALPHWRAAPPRVRAEILRGAFELMVREREQIAELIVRENGKVRADALAEADYAAEFFRWFSEEAVRIGGDFRTAPGGDKRIVVTRQAIGVSVLITPWNFPAAMATRKIGPALAAGCTVVLKPAAETPLTALYLADLLERAGVPSGVVNVVVPDPPADAVRAMLSHPAVRKLSFTGSTEVGRVLLRTAADQVLSCSMELGGNAPFIVLDDADIDAAVAGAMVAKMRNGGAACTAANRFYVAEAVHDAFVAAFGAAMDALPLGPGTDPDNALGSLVSVAERDKVAARVTRAVEQGATVQAGGTVPAGPGAFYPATVLSGVRHGDDITRAEIFGPVAPIIAFGPEDDVAALANDTELGLISYVYTGDLARGIALAERLETGMVALNRGVASDPAAPFGGAKQSGLGREGAAEGIQEFLEEKYIALDLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E421</accession>
    <name>A0A1H6E421_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugative relaxase domain-containing protein, TrwC/TraI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92468">
        <property type="protein sequence ID" value="SEG92468"/>
        <property type="gene ID" value="SAMN04489712_1345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="1">
        <location>
            <begin position="48"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="34534" checksum="B20AE6347D684011" modified="2017-01-18" version="1">MGHGGGDVAVAWVTAIGPAIAQVDYRLEASAGCGLSREHGHAAEAEAQAGYRMDEADRLTWFGGGLAEVGITAGAALAGEADKAKARALMDGVHPQTGERLVEPKRAAHPRGKLPAAPFLAAVEELAAARGVPATEVAASRWGRARLAQMTRMVAREGETHRVAVKDLERLAGALGVDLGAVYEARELTVARAHRAETVRVGDRGFDLTIDIPKTPSVWWALADPQAAALLQNAFREAVTETLAEVERWCGYVMRGKHGDGRTARRIPTSGLLGWVMWHDVARPVAGQTPDPHLHAHAVIAHMVCGADGRWSTLATAAGSSTGMWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E467</accession>
    <name>A0A1H6E467_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92377">
        <property type="protein sequence ID" value="SEG92377"/>
        <property type="gene ID" value="SAMN04489712_13333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="187" mass="20796" checksum="5D9EA67B9A5DAB31" modified="2017-01-18" version="1">MRLFVALVPPPDVLDELDRLLESYRASWPDLKWISRDMMHITLAFLGETDERTIARLLPRLERAAGRYPKIELSFAGAGAFPSGGAHARVLWTGVYGDRGVLTRLAASVNAAGRRAGAPLGEHKGFRPHLTLARSRRPTDMRPLVEELSAYAGATWTADAVHLVRSHLPGKNYPGFRYEIINTWPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4P8</accession>
    <name>A0A1H6E4P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92219">
        <property type="protein sequence ID" value="SEG92219"/>
        <property type="gene ID" value="SAMN04489712_13260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="108"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="31330" checksum="CA5214B72911525F" modified="2017-01-18" version="1" fragment="single">IPVAVACRVLNVSTSGYYDWLGRPESPRALRNKEPAKMIREIHAESRGSHGSPRVHAEPALGLGEQVNRKRVERLMRRAGLQGVYRRRGRRDLVNAATEEDLVQRHFDVAGPDRLWLTDITEHPTTEGKLYCAAVLDASCGRIIGWSIDTRQDTDLVINALAMAVTRRNPPPRSTILHSDHGTQYTSWAFGKRLRDAGLLGSMGTVGDCYDNSMMESFWGTMQLELLDTRTWKAREEPAGAVFEWIECWYNSHRRHSSIGMHSPVAFEGLNLPSDTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5L7</accession>
    <name>A0A1H6E5L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92185">
        <property type="protein sequence ID" value="SEG92185"/>
        <property type="gene ID" value="SAMN04489712_13250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="30356" checksum="454386437AD617C3" modified="2017-01-18" version="1">MSDSPSRARWRELTDFMRTDILDGHYQPGQALPGEAHLADTYATSRPTVRKAIAQLAAEGLLTVSHGRGTFVRPRPDRRLIVIGQGPHLDLLAPNSDLAAQGWEPVTVPSDAERQDPEFAHGQPIPNPCGLEEAEALGIRTGTKVIHRYAFWQHTKTRTRIYLDSNIPRDLLTTDDQDAEIQPQDYYAHLADRYGPVRWTTTVHATMPTGHMTEDLNMEATGTPTLVIRRIMLNTQGRPLEVTEIHAPADRFEATSATDHDPTALADITALHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E672</accession>
    <name>A0A1H6E672_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93288">
        <property type="protein sequence ID" value="SEG93288"/>
        <property type="gene ID" value="SAMN04489712_1389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="BLACT_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="74"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="311" mass="33605" checksum="CBE628D021A0AC41" modified="2017-01-18" version="1">MSRIPPASLFRRGGLFGQGVPRAIAWRLAGTSVLRHLGALTGERMAWMHEIDGMGTERATCVLAPNPSAMTLDGTNTWVVAEPDAAEVVVIDPGPKDLKHLRRVARKIEESGRRVGLIVLTHGHPDHAAGAGKFAELTGTRQVRALDPRHRLGEEGLTEGQVITVGGLELHVMETPGHSHDSLTFWLPADGAVLTGDTVLGYGTTVVEGRLGDYLGSLERLRRFSEETGAQVILPGHGPSLDDPIGALDGYLTHRRQRLAQVEAAVEAGARTAREVVERVYADVDRSLWPAAEWSVQAQLDYLKDVGRLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E857</accession>
    <name>A0A1H6E857_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosaminyl deacetylase, LmbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93877">
        <property type="protein sequence ID" value="SEG93877"/>
        <property type="gene ID" value="SAMN04489712_14117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="21853" checksum="244998B9D57B9799" modified="2017-01-18" version="1">MSTPTWPGSVLAVMAHPDDAELWAGGTLALHAANGVAVTIAVASHGAVRDAETAAGAAVLGAEIHLLPEMTAETVGDLLRLHRPEVVITHALQDVHPEHRRAGQAVLEALPDVVIDTGHPRRVYGCETYNGLTLDGTTQPRAVVDISDTYATKTRALDAHRSQPIQNHFGPMAETLARLWGARIGTAYAEAFTAVPVLGQLPATPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E884</accession>
    <name>A0A1H6E884_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR system Cascade subunit CasE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93907">
        <property type="protein sequence ID" value="SEG93907"/>
        <property type="gene ID" value="SAMN04489712_14129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010179">
        <property type="entry name" value="CRISPR-assoc_prot_Cse3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08798">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01101">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01907">
        <property type="entry name" value="casE_Cse3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296638" evidence="1">
        <location>
            <begin position="28"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="25884" checksum="6D025A497F54A5D2" modified="2017-01-18" version="1">MYLTRFRVNTARVTARKVLSSPQVLHAAVMSSFATVPVQEDDGPRVLWRIDRNSKAETYLYIVSPIKPDLTHLVEQAGWPTTGGWQTYDYEPFLSRLTKGDEWAFRLTANPVHSARRNDTEPTKVTAHVGLQHQLRWLLQRQETAGFRVVEKPAERQVIPGTDVHELVIRERRQLTFRKKGHSKPVTLVTVTFGGKLEVTDPDALRRTLTRGLGRAKAYGCGLMTLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EA41</accession>
    <name>A0A1H6EA41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_14216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93979">
        <property type="protein sequence ID" value="SEG93979"/>
        <property type="gene ID" value="SAMN04489712_14216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="13"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG93979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="334" mass="35888" checksum="2050BF3AB6B63B0E" modified="2017-01-18" version="1">MNTTDTSTQDPLLRVEDLVVQYPTDAGTVHAVSGVTFDVHRGETLGIVGESGSGKSTLLRALLRLTPHTGGSVRYRDTVLTDLGEEPMRRLRPSLQMIMQDPIASLNPRRKVRDIVAEGLRIWPDRVTTSVEEQVAAGLDAVGMDIGIVGDRRPGSFSGGQCQRIAIARALALRPDVLFCDEPVSALDVSVQARVLNLVHDAKEALGLTVLFVSHDLGVVKSVSDRVMVMYLGRICEIAPVEEIYESPAHPYTNLLLSSAPGSHRPAPPDLTGETPSPLDPPSGCRFRTRCPLAQERCAAQAPPLRALPGGRGVACHFPLVTEDRDEAEAGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SVA2</accession>
    <name>A0A1H5SVA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54440">
        <property type="protein sequence ID" value="SEF54440"/>
        <property type="gene ID" value="SAMN04489712_101377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF54440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="40310" checksum="872BD30E61ACAE8A" modified="2017-01-18" version="1">MGEGAAIAGLGMTELGRVYGRSPRRLAADAVRRAVTDAGLGLADLDGLVVSHGLGGSPGIELADTMGLRDLRVLTVMNSFGATAGAMVAYAAMSVISGAASAVACVFADAPLRPRQSSGSAYQRDAREWYGFGGMTAALGFRDVNTPYALAARRHMNRYGTTSEQLGAIAVSTRQWAVMNPLAQMREPMTLADHQNSRWVAEPLHLLDCCLVSNGAIAVVVTGADRARDLARPPVHIWGWGQGHPGHSKERGSEFGLTTGAAVSGPTAMKMAGVTAQDVDICQLYDCYTYTVLVSLEDYGFCAKGEGGAFAASGALGPGGALPTNTGGGQLSAYYMWGMTPLSEAVIQARGDGGERQVAKNDVVLVSGNGGILDHHSTLIVSPHRKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T316</accession>
    <name>A0A1H5T316_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-(Acyl carrier protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57169">
        <property type="protein sequence ID" value="SEF57169"/>
        <property type="gene ID" value="SAMN04489712_101462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF57169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="26018" checksum="66704CA0F398B7FF" modified="2017-01-18" version="1">MRFADKVAIVTGAGQGIGEAYAKGLAAEGARVVVADLNSGQAERVAKEIAAAGGAAHAVVTDVSDPDSARAMADAATEAFGGIDYLVNNAAIYGGMQIESLMKVDLGYYRRFMSVNMDGVLHCTRAVHRAMRERGGGAIVNQSSTAAWMAGGFYSIAKAAVNSLTVNLAAELGWMNIRVNAIAPGPTDTAATRGVVPEEFIDPMVQNLMIKRMGTPDDHVGALKFLLSDEASWMTGQIVAVDGGQIVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T8H9</accession>
    <name>A0A1H5T8H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type branched-chain amino acid transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58391">
        <property type="protein sequence ID" value="SEF58391"/>
        <property type="gene ID" value="SAMN04489712_101502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="82"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF58391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="451" mass="50114" checksum="75815F16F1C041BC" modified="2017-01-18" version="1">MTEQDDSRYAERMFPAPADHGVARPDRAVATVRSGTDTAADGDYSNELWYQGSGRIGEKAVERIVVYPPTGGLQTQGDPFEPVRIGLLIDMDLGQLLADTIDPIILAVEDALNEGVYDRPVEIVTVDARGLPRENYLKVRKGYQKLVDEGCVVVIGPFISDNSLNLRDTINATGVPCLGWTGTTLFHGEYCFTVANGDIPVEGGMAANWCAQNGLDKVGFFWEQGSSGDLYADYFRAAARQYDVDIVKEVRLGPNPRNLRQHLETMRAQGARSIVYMGYGYSTFHFADAFKTMDWDPPRFMGTAFMFYSNSNKWAEGLEGWHGVDQLGEDGANPNYEAMLERFEARFGRVSRNVVVALSYDTARAAIHGIANARIAVPEEVKAGLEKIKWMPCTNGGPGCYLTFAEYDHRGYKGDFLTIRELRGGELHFRGYHRPTWPSNTRSPLLKQSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TE74</accession>
    <name>A0A1H5TE74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosyl-3-phosphoglycerate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61099">
        <property type="protein sequence ID" value="SEF61099"/>
        <property type="gene ID" value="SAMN04489712_101584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="42"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF61099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="35804" checksum="828BA1F9768ABF0B" modified="2017-01-18" version="1">MLTEATMWMRRRTSTAADWPVETLLAAKAAQAVTGPGQGRISVVLPARNEEETVGTIVAAIRRELVERAPLVDEIVVIDSRSTDRTAEVAAAAGAEVVAQDAVLPELPRMSGKGEALWKSLAATTGDLIVFVDADLRNFSPHFVTGLLGPLLTDPSVGYVKGCYDRPLVTGGTRVDGGGGRVTELVARPLINLHWPALAGVLQPLGGEYAGRRSLLERLPFVTGYGVELGLLLDVFADSGLDALAQVDLGDRVHSHQSTEALAAMSGQIMLTAWSRLQRHGRMLPLEDPATALAWFQRTGTGHDVRVNDVGVQERPPMIEVPGYAGTGRSLLPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TRI2</accession>
    <name>A0A1H5TRI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65376">
        <property type="protein sequence ID" value="SEF65376"/>
        <property type="gene ID" value="SAMN04489712_101719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF65376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="33083" checksum="5B2FC3A86CE98193" modified="2017-01-18" version="1">MPARVRPAGGRVAVLGGTGWVGRFICAALAERGQDPLVVARNRVPHVAGYDFRSIDLVTADVGTLAKVLRTEGVDIVINATDGANTNDGWDRTEAELRRANAEAVHRVLGAMAELPWRSRVVHIGTIHEYGPVGVGTPVAESVTPRPVNAYARTKLAGSVATLEAVREGVVDGVVLRLANVCGPHPSPASFPGKLLSLFREAAAGGRVELSIADARRDFVDVRDVADAAVKAAEASVTGRAVNIGSGMAVEIRDLVAHLAEAAGVPPDAVKETGAPVPSLGGDWIQADIRLAARVLRWRPHIGLAESLRAMWETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TTM5</accession>
    <name>A0A1H5TTM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66222">
        <property type="protein sequence ID" value="SEF66222"/>
        <property type="gene ID" value="SAMN04489712_101743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF66222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="118" mass="12970" checksum="E78FB8F632FF521F" modified="2017-01-18" version="1">MHEDARDDTVTFVNRFTVHASPDEFERVFAETAEFMARQDGFLQHTLLRHVDDERSYVNIAQWRDEAAFRAAVAAPGFGPHAASLRALSASEPSLYTPAAPTRRSPLAEAGDGPAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U1G5</accession>
    <name>A0A1H5U1G5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68944">
        <property type="protein sequence ID" value="SEF68944"/>
        <property type="gene ID" value="SAMN04489712_101834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022017">
        <property type="entry name" value="DUF3598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12204">
        <property type="entry name" value="DUF3598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3598" evidence="1">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF68944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="17555" checksum="3BD2DCFFF65B22B5" modified="2017-01-18" version="1">MTSLRERLGSVTGVWEGVYTHLTPAGAVLETYGSRQETRLEGDHWYERIIYRRPETEPQMLDFRARFDSDDDLVFGSADFQGRARLVDGRFLLFTYRWTAEPGVEVVELITFARDDYKSRLWKTFRDGRLEQVTVVEEHRVPGGVPEVWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U2E9</accession>
    <name>A0A1H5U2E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68421">
        <property type="protein sequence ID" value="SEF68421"/>
        <property type="gene ID" value="SAMN04489712_101816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF68421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="360" mass="38214" checksum="5115CF1911565B71" modified="2017-01-18" version="1">MSSETTRLSSVAGTVEDAYAGAFAALAETGLGPADVVQVVEYATKDALDSYERVENARAAALGGHQAPIATVGVEGLPQRGAELAVELTAFPGGGQLVQAHPDEGFHRGTMRIADEIVYLPSIHPHDGTSIVFADDFRGQYRYCLERAGELLKVAGVGLDTLVQTTDYTAQATRAQYPRCGRPRKELLGGTGSDGRPVHPGAAGIVIDQAVVPGAMASLDAIASTAPFRTVNPGWRRYETLTYKPGLATDRTLFMSGFGSLEPATQKCIFEGDLLAQAEYTYASIAAVLREAGLGETLPYGSVTRLVEYVTPGSVERYAEVAEIRRKYFGDTPALTSVVCSALLRPELLIEVVPTAVFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U589</accession>
    <name>A0A1H5U589_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69598">
        <property type="protein sequence ID" value="SEF69598"/>
        <property type="gene ID" value="SAMN04489712_101858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="175"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF69598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="35957" checksum="D50F6397E8B5C940" modified="2017-01-18" version="1">MRAVVMHAPGDVRVEQREDPKILAPTDAIIRLSAACVCGSDLWPYRGVEKHDGPVPMGHEYVGVVEEVGSEVRDLKPGQFTVGSFFASDNTCEICRAGYQSRCVHAVPMAAIGTQAQRARIPLADGTLVATPGMPGADLIPSLLAASDVLGTGWFAAVAAEAGPGKTVAVVGDGAVGLLGVLAAGQLGAERIVVFSRHADRQKLAVEFGATDIITERGDEGVARLKDLTGGLGAHSVIEAVGTQESMMQAIRSARPGGHVGYVGVTHDVELPGMELFFSGVHLHGGPAPVRRFLPELIQLIWDRKIDPGKVFDLELPLEQAAEGYKAMDERRAVKVLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UUJ6</accession>
    <name>A0A1H5UUJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Toprim-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78151">
        <property type="protein sequence ID" value="SEF78151"/>
        <property type="gene ID" value="SAMN04489712_1028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Toprim" evidence="5">
        <location>
            <begin position="457"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF78151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="680" mass="74027" checksum="87A150AEB83D9ED7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V0J1</accession>
    <name>A0A1H5V0J1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hutU</name>
        <name evidence="13" type="ORF">SAMN04489712_102110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80724">
        <property type="protein sequence ID" value="SEF80724"/>
        <property type="gene ID" value="SAMN04489712_102110"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="136"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="346"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEF80724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="551" mass="59217" checksum="414C31E65C9797A9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VFN9</accession>
    <name>A0A1H5VFN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aromatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85601">
        <property type="protein sequence ID" value="SEF85601"/>
        <property type="gene ID" value="SAMN04489712_102286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF85601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="314" mass="34774" checksum="617046D145B9B0BF" modified="2017-01-18" version="1">MTGPGRREVEHEITVRAPAATAYRLIAEVAEWPRIFPPTVHVDHLERAPGHERIRIWATAEGEAKTWTSRRVLDPGGLRIEFRQEVSAPPVASMGGAWVIEPVGEDESRIRLLHDYRAVGDDPDDLAWIDRAVDHNSRAELAALKVNMERAVDSADLLLSFEDTVRIAGSAKDAYDFVNDAHLWRERLPHVARVSLTEETPGLQTLEMDTRTKDGSTHTTRSVRVCFPHQRIVYKQIVTPALMTLHTGAWLFTDTGDGVTVTSRHTVMINPDTITKVLGEGAGVAEAREFVRTALSGNSLATLGHARAYAESRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VYR5</accession>
    <name>A0A1H5VYR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="13" type="ORF">SAMN04489712_102512</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92136">
        <property type="protein sequence ID" value="SEF92136"/>
        <property type="gene ID" value="SAMN04489712_102512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="12">
        <location>
            <begin position="321"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="72"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="439"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="451"/>
            <end position="456"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEF92136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="695" mass="76291" checksum="DB35D2F3C1CDE958" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W6L4</accession>
    <name>A0A1H5W6L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94811">
        <property type="protein sequence ID" value="SEF94811"/>
        <property type="gene ID" value="SAMN04489712_102598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF94811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="112" mass="12441" checksum="4167A4C6877F61F8" modified="2017-01-18" version="1">MSVGDIVVIESPGRDLSWTTPPATRWTRDRRWLVKRVVAVPGDRRPDVLPAVTRVPEVVAPKTLIVLSDNGGLDSRVFGPIPFERLFGVAVRRMFDERGGGREAIRRDAPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WAL4</accession>
    <name>A0A1H5WAL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sporulation and spore germination</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96231">
        <property type="protein sequence ID" value="SEF96231"/>
        <property type="gene ID" value="SAMN04489712_102641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Germane" evidence="4">
        <location>
            <begin position="217"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF96231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="598" mass="64058" checksum="AE9DFC0CF6820AE2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WDA2</accession>
    <name>A0A1H5WDA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97455">
        <property type="protein sequence ID" value="SEF97455"/>
        <property type="gene ID" value="SAMN04489712_102678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF97455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="36733" checksum="82861FF6BF84DF05" modified="2017-01-18" version="1">MEAILLVGGQGTRLRPLTLSTPKPLLPMAGVPLLEHQLTRAREAGVRRIVFATSYRASMFGEAFGDGSRLGLEIVYVTEDEPLGTAGAIRNASEALTGGSADPVVVLNGDILSSHDLSAQLAAHRKADAAVTLHLTLVEDARRYGAVPTSPDGRVLAFVEKSPNPPTNQVNAGCYIFRRSVIDEIPPGRVVSAEYEVFPGLLAGGAAIIGYVEAAYWLDVGTPAAFVRGASDLVTGAMTSPVVSGAEHGVLSLDGAFIAPSAQVGGGTTVGEGARVGPKARVESSVLFDGAVVESAARVVRSVIGRGARICTGAVLEDVVIGDGACVGPGNELLNGLRVWPGVELPPMAVRFSHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X813</accession>
    <name>A0A1H5X813_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell envelope-related function transcriptional attenuator common domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07406">
        <property type="protein sequence ID" value="SEG07406"/>
        <property type="gene ID" value="SAMN04489712_103112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="176"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG07406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="412" mass="44872" checksum="431B039C00EE16CC" modified="2017-01-18" version="1">MREMDARSAGFEYLDGMTDGWPEGWTRQGRRERRMDAPTERMPPQEEAYDAYDPYDARREAAHQDYGPPPGYDARDDFGYEQPPPRARRGAARRAGGRRRWPRVLGALVALLLVVVVGGYFYLDSRLRREAVLEDYAGRPADTPGTNWLVVGSDSREGLSKEQRKEFATGNASGRRTDSMMLLHYGAGGTTLLSLPRDSYVPIPGRGSNKLNAAFAFGGPKLLVQTVEKATGVRVDHYAEIGFGGFVGVVDAVGGVDICVERPLKDPKAGLDLQAGCHTLSGGQALGFVRTRNFTNGDLERVQNQRKFFAALMDKATSPGVMFNPFRGVPLALNSTSNFTVDENDHLSDLARLMWAMRSVSGGGGITTTVPIAGFGSAPGVGSYVRWDTAKSSALFEALREDKPVPSSVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X871</accession>
    <name>A0A1H5X871_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="14" type="ORF">SAMN04489712_103135</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07942">
        <property type="protein sequence ID" value="SEG07942"/>
        <property type="gene ID" value="SAMN04489712_103135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG07942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="11352" checksum="50B584E08D49ED49" modified="2017-01-18" version="1">MAQVRRQANLPRPSWGWQDAAACRGEDLVLFFGPDGERQPEREIRERKAKQICMGCPVRSECLDYAVSRPEKYGTWGGLNEDERASERRRRMRRANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XC07</accession>
    <name>A0A1H5XC07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09193">
        <property type="protein sequence ID" value="SEG09193"/>
        <property type="gene ID" value="SAMN04489712_103183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG09193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="21374" checksum="15BEF12CC2F3BA8F" modified="2017-01-18" version="1">MNRKVEQGDATRAQLVDAGVALFTEQGFAGTSTAEIVRRAGVTRGALYHHFADKEQLFEAVHVEIQKDIFARCAAASAAAPADPAARITAGVLAFLDACMEPRVQRILLREGPSVLGWERSLRFDDPYCARRLLLSALRGAARDGLVPDGHAEPLAHALFGALNQAGNLISAAADPVAERERMGRAIADLIAALLRANPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XDZ4</accession>
    <name>A0A1H5XDZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09939">
        <property type="protein sequence ID" value="SEG09939"/>
        <property type="gene ID" value="SAMN04489712_103211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG09939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="45" mass="4905" checksum="40A395CDED3A17BA" modified="2017-01-18" version="1">MILRPGGVRIPDMRGIFRAHHGDDVKVIQDTVSFRAPDGHNGAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XRF4</accession>
    <name>A0A1H5XRF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14284">
        <property type="protein sequence ID" value="SEG14284"/>
        <property type="gene ID" value="SAMN04489712_103374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG14284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="24846" checksum="F752D5EFA0FFE072" modified="2017-01-18" version="1">MTIRVVIVDDQGMVRAGFGVLLNAQPDIEVVGEAADGETGLRVIDALRPDVVLMDIRMPGLNGLEATRRLLARDHPPGGSETGRDDPPKVLVLTTFDLDDYVYEALRAGASGFLLKDASATELAEAVRVVAAGDALLSPSVTRRLIAEFARLGAPRSPRRERLADLTERETEVLALVARGLSNQEIAAELVVAEQTVKTHFGRVLMKLGLRDRPQAIVYAYETGLVRPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XWD2</accession>
    <name>A0A1H5XWD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15700">
        <property type="protein sequence ID" value="SEG15700"/>
        <property type="gene ID" value="SAMN04489712_103428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG15700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="32577" checksum="A364659CF1E3D53A" modified="2017-01-18" version="1">MTEQRPRPTVRRRRLSRELRALREAAGFTAEHVTRELEWSKGKLSRIENNDWRRPSIQDIKALLEVYEVTDPERREAMLQLTRDSRQRGWWTGYQDVFQNLGYTGFEQEASRVLTYEQSAIPGLLQTPAYAEAIVRASLVQDPAEVARRVELRMERQRILEHADPLHLWAVIDEAALSRPFGSLDDQREQLQRLIDTKDLEHVTVQVLLTTAGLHPAMSGSFVILEFPEDPSVVYLSPGGHELYLETPEDIDRHALVFRHLNAMALSPADSTECFAAKIRELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XWQ7</accession>
    <name>A0A1H5XWQ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sigA</name>
        <name evidence="10" type="ORF">SAMN04489712_103442</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16082">
        <property type="protein sequence ID" value="SEG16082"/>
        <property type="gene ID" value="SAMN04489712_103442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="9">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="316"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="395"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="484"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="340"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG16082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="549" mass="59672" checksum="478C27F7EC387EC6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y2E6</accession>
    <name>A0A1H5Y2E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17965">
        <property type="protein sequence ID" value="SEG17965"/>
        <property type="gene ID" value="SAMN04489712_103516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="33629" checksum="77378133EA065023" modified="2017-01-18" version="1">MKAVVYERYGRPDVLRVEDVPMPSPAAGQVLVKVAATSINLSDWEGLSGSPFYARLGGVRAPRRSILGSDIAGWVEAVGTGVTRFQPGDEVYGDNLQLKGGFAQYAVAPESALAIKPAALTFAEASTIPQAGAIAVQGMAGAAEGRRVLINGAGGGTGSFAIQVAKRLGAHVTGVDNGHKLEFMRSLGADAVIDYRRDDFTREHEPYDLILDLVAHRSVFAYRRALAPGGRYRCAGGSVRALLRVLTIGAAAGRVTGRRLGVLVVREGPPHFEPMTRLCVAGDVSIRIDRTFELDQVPDALAHVGEGRALGKVVVTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YVG0</accession>
    <name>A0A1H5YVG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tilS</name>
        <name evidence="9" type="ORF">SAMN04489712_104192</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27732">
        <property type="protein sequence ID" value="SEG27732"/>
        <property type="gene ID" value="SAMN04489712_104192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="27"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="TilS" evidence="8">
        <location>
            <begin position="255"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="32"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG27732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="35162" checksum="C7CF8369D5AB0AB4" modified="2017-01-18" version="1">MGPDPAVATVRVAVRRALNDLPAGARVLVACSGGADSLALAAAVAFEAPRAGREAGGVTVDHGLQEGSARVADAVVRTMRDLGLDPAGSVAVTVGAHGGPENAARHARYTALDEAAGRLGAVVFLGHTLDDQAETVLLGLARGSGARSLAGMPPDFRRGEIRYVRPILALDRATTRRACLAMDLEPWDDPHNEDPAYTRVRLRHEALPALEKALGPGVAAALARTARLLRDDAEALDALAARAYADVLDGEGGGLDVAALEALPRAVRTRVLRRAAIEAGGPAGTLAAVHVDELDRLVTAWRGQHHVDLPGGVRALRRYGKLLFRRRGTAADGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YVK8</accession>
    <name>A0A1H5YVK8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 11">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_104215</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 11"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28283">
        <property type="protein sequence ID" value="SEG28283"/>
        <property type="gene ID" value="SAMN04489712_104215"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="12">
        <location>
            <begin position="18"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="13">
        <location>
            <begin position="439"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG28283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="551" mass="57313" checksum="AC057751BF755FF1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXK5</accession>
    <name>A0A1H5YXK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ORF">SAMN04489712_104248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29009">
        <property type="protein sequence ID" value="SEG29009"/>
        <property type="gene ID" value="SAMN04489712_104248"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="160"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG29009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28106" checksum="26A8B7138F0E0E4F" modified="2017-01-18" version="1">MGKLIAILGAGKMGEALLSGVLRAGRRPAELLVTTRREERGALLRERYGVEVVTNAEAAKRADTLILSVKPQDMGTLLGELHPHVPAGRLVISMAAGITTGFIEERLPAGLPVVRVMSNTPVHVDEAMSVVSAGSHAAEEHLRVAEELLSPVGRVLRIPESLQDGATALSGSGPAYFYYLVEAMVDAGILLGMPRAAALEMVIQSAVGAAVMLRDSGEHPVLLREAVTSPGGTTIAAIRELERHGVRAAVIEAIEAARNRGRELAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z0Q5</accession>
    <name>A0A1H5Z0Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_104275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29620">
        <property type="protein sequence ID" value="SEG29620"/>
        <property type="gene ID" value="SAMN04489712_104275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="8">
        <location>
            <begin position="47"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG29620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="546" mass="59161" checksum="C1135B71304275BA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z419</accession>
    <name>A0A1H5Z419_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31309">
        <property type="protein sequence ID" value="SEG31309"/>
        <property type="gene ID" value="SAMN04489712_104351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG31309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="113" mass="12018" checksum="557F1F5F93B1674A" modified="2017-01-18" version="1">MRNMPIDTTNLAFVCVSPPRPKLVNQETGEIKMDKNGDAVYQVGLSCSNAEGRVDLLTVQVTGDPGVTLGQVVTPVGLVGFFWEQTINGERRSGVSFRAERVVPVGAENAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z5P0</accession>
    <name>A0A1H5Z5P0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_104371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31678">
        <property type="protein sequence ID" value="SEG31678"/>
        <property type="gene ID" value="SAMN04489712_104371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="16"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG31678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="15028" checksum="36CC3441D7D51A72" modified="2017-01-18" version="1">MTAGVKYDDVEVGTEIPARTYPVDRANLVMYAGASGDFNPIHWRESFAKSVGLPDVIAHGMFTMAQGGRFVTDWVGDPGAVVDYGVRFSSPVVVPDEGGATLEISGTVEDKLDDNKVVVALTARCNGQKVLTRAKAVVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZFB5</accession>
    <name>A0A1H5ZFB5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">purH</name>
        <name evidence="10" type="ORF">SAMN04489712_104525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34961">
        <property type="protein sequence ID" value="SEG34961"/>
        <property type="gene ID" value="SAMN04489712_104525"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG34961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="522" mass="55076" checksum="94D8264E3BFAB4D0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZC8</accession>
    <name>A0A1H5ZZC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDP-glycerol glycerophosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41462">
        <property type="protein sequence ID" value="SEG41462"/>
        <property type="gene ID" value="SAMN04489712_10580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="6">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG41462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="946" mass="106636" checksum="31F273AE1450A686" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A6A3</accession>
    <name>A0A1H6A6A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxo-dGTP diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43902">
        <property type="protein sequence ID" value="SEG43902"/>
        <property type="gene ID" value="SAMN04489712_105222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG43902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="130" mass="13931" checksum="DFB1EF5343C376EB" modified="2017-01-18" version="1">MVLIVVVVGAAIIRAGRLLAAQRAEPPRLAGGWELPGGKVDPGESEEDALVRECHEELGVKVGLGARIGGDWPLSDEGSVLRVWTAEILEGEPAALEHLALRWLGPAELYEVDWLPGDLPVIGALHDHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJ13</accession>
    <name>A0A1H6AJ13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48382">
        <property type="protein sequence ID" value="SEG48382"/>
        <property type="gene ID" value="SAMN04489712_105472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG48382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="14102" checksum="1CE38F48F9B7F3A6" modified="2017-01-18" version="1">MSIRRRSLISRTTRTPDLVLVLPKDLNESETLTDLAEAIGQFRKILTDRVDHLTRASQRLQGGKADLADLRGQLDAYTEAVAHLDEEIITRFDLWDQYARWSRSRTDRRERTFIERSRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AY52</accession>
    <name>A0A1H6AY52_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53498">
        <property type="protein sequence ID" value="SEG53498"/>
        <property type="gene ID" value="SAMN04489712_10696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="16629" checksum="11B3991057D3C4E8" modified="2017-01-18" version="1">MALHWKLVVDTRDAPALADFWAAALEYEVEDQDSLIEHLLATGRLPEDAVAEHRGRRIFCGHAAIRHPEDPFDETTGVGLGRRVLFQDVPEAKTAKNRLHLDLHAAPGGLDALVTRLETLGATRLHEVDKGPAGHWWVMQDPEGNEFCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2X3</accession>
    <name>A0A1H6B2X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Maleate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54960">
        <property type="protein sequence ID" value="SEG54960"/>
        <property type="gene ID" value="SAMN04489712_106192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG54960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="247" mass="27157" checksum="16AB7347EE175804" modified="2017-01-18" version="1">MTDALGWRRKFGVIAPSTNTIVEPDFYRMGVPGVTSHFSRIHIRDQNMDGDEGMQRLLEQIRAEIGAACERVLTCEPDYMVMGMSAETFWGGVAGNKEFVRQIHDITGLRVATGAEACERALKLYGARRIGVVTPYQPIGDENVVRFFGELGFEVDRIIGLKCPTAVSIAHVTEDELRSALRELAAGEVDALVQCGTNLSMVGLADEAERWLGLPVIAINAATWWMALRDNGIEDKVHGAGSLLREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3A7</accession>
    <name>A0A1H6B3A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_106223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55329">
        <property type="protein sequence ID" value="SEG55329"/>
        <property type="gene ID" value="SAMN04489712_106223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG55329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="27146" checksum="8BA4A78904131AB2" modified="2017-01-18" version="1">MTGLGHRLHRPGSTPVHRLPPQCKLVATAAFVLAVVCTPREAVWAFGGFALLLAAVAALARVTPGFLVRRMAVEVPFVAFAVLLPFVARGPRVEVLGLALSQSGLWSAWNILAKASLGTAASVLLAATTEPRQLLLGLERLRLPPLLVQIATFMLRYADVIVGEMRRMRLARAARGFDGRDVRAFGVLARSAGALFLRSYERGERVYLAMLSRGYDGRMPVLNEIAATRAQWAVAAVLPVAAVLVASGAWMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3K9</accession>
    <name>A0A1H6B3K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AraC-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_106211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55190">
        <property type="protein sequence ID" value="SEG55190"/>
        <property type="gene ID" value="SAMN04489712_106211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="211"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG55190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="334" mass="36041" checksum="E11D66C6458616CA" modified="2017-01-18" version="1">MDALAGLLDGPRARGAFLLRTALDPPWGLRIQDRAPLTLMVVLRGHAWAMPDEGEPVQARAGDVMIARGPDPYTVADDPATPPGIVIHPGGRCATPDGRDLYDEMLLGVRTWGTGPDAAHQMLVGTYQMSGEIGGRLLDALPALLVLPGEALDSPLVTLLAAEMARDEPGQEVMLDRLLDLLLITVLRAWFARREAAAPAWYRAHSDPVVGRALRMLHNDPARPWTVASLAAEAGVSRAALARRFTALVGEPPMAYLTGWRLALAADLLREPDATVGSVARQVGYAGPFALSAAFKRVRGVSPRQHRSRVLHDRHDHPANLRKPVESGDQSQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3Z5</accession>
    <name>A0A1H6B3Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54947">
        <property type="protein sequence ID" value="SEG54947"/>
        <property type="gene ID" value="SAMN04489712_106191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG54947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="23540" checksum="38E4A4CD2B3501EE" modified="2017-01-18" version="1">MSGYDYPVALALEDYVPVLLTGAGLALLVPYARRFGTAPVVALGAVLATAGGLSKATWKLVVALDGPDLHWLNSALFPLLCTAFLLLLYAFHRPRDARRRAALTAGLAVLFALGQGACVAVGDTWPAMALMIVAVSVLTVRFVMLARAAGDVPAVVLFSLWQIGQYLLGPMAARADQSVTLQWVEQSCNTVAQGAFAVATWRLAHAPGAPISASTPASTREVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B880</accession>
    <name>A0A1H6B880_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56417">
        <property type="protein sequence ID" value="SEG56417"/>
        <property type="gene ID" value="SAMN04489712_106311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="45463" checksum="01DAC6B14EA4FDD2" modified="2017-01-18" version="1">MVRNIAFPFFALVLTGILVYKVRHMRAQRGNAGLWALCGTVFFFGMTMWSASPASAAWINRVTGVTNLAELVAAVCLSALAASFLVLALLWRYPAAVAWRRLRWVLVVYSLVIVTISVLFALSEVPVERTIDYPYYYATQPTVAVSYAIYYSATLIGSAILARWCFTWARHDDYAALPYLRRGLRLYAGAGVTMTTYSALRLVSIGGNWFGTDVLNQAGSVTSLVAAPFGCFFLTAAMVVPMWGPRWPVVRRTVRRWPRYRTLRSLHRRLTEVNPSVVFVARGRRLDLQHRIRRAIIELSDWRWALAPLFDTAVEDAVWALGRARGVPAEQLPVLVEAAQLRVALESWRRGARGAEAPADRFHDERDGNDIDLELAWWCQVARAFKDSPVVERAVAGIRGAAPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BI22</accession>
    <name>A0A1H6BI22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recO</name>
        <name evidence="10" type="ORF">SAMN04489712_107126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60363">
        <property type="protein sequence ID" value="SEG60363"/>
        <property type="gene ID" value="SAMN04489712_107126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="9">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG60363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="28790" checksum="82B6C3AEEC86973C" modified="2017-01-18" version="1">MRDNAGVSLYRDEGIVLRTQKLGEADRIVTVLTRRTGRIRAAAKGVRKTKSRFGARLEPFTHVDLQFYERRSLDLITQAETLRPYGEPLVTDYPRYTAGTAMLETAEKLTAEEKEPALRQFLLLLGGLRTLADGAHDPRLVLDAYLLRSLSVAGWAPALDECVACGSRNRLRAFAIAAGGAMCGNCRRPGAATPAPPTLELMLALLRGDWEHADGSQPRHRAECSGLVAAYLQWHLEHGIRSLRHVEREAAPITTIDEEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BID2</accession>
    <name>A0A1H6BID2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59966">
        <property type="protein sequence ID" value="SEG59966"/>
        <property type="gene ID" value="SAMN04489712_107101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="130" mass="14889" checksum="6F32C99AB4B970F6" modified="2017-01-18" version="1">MNFYSPAQASQRSGFSLDTLRYYEKIGLLAGVARDSAGRRRFSDDDLTWLRLLRCLRDTGMPIAEMLRYTELARAGEHTAAERRALLEEHDRRVAEQIDLLSRQREHIQWKIGIYRELTAPAPAADPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BIN1</accession>
    <name>A0A1H6BIN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hemolysin, contains CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_107142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60599">
        <property type="protein sequence ID" value="SEG60599"/>
        <property type="gene ID" value="SAMN04489712_107142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="207"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="275"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG60599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="437" mass="47425" checksum="0E56750F95B06D86" modified="2017-01-18" version="1">MSTAHGWLLGMAAGLVVVAGLLASVETALTTVSRVRVEELTREGRRGARLLAEMVADPASYLNLVLLLRISCELAATVIVADLCISWLAESWPAYVVAAVIMIVVIYVVVGVGPRTLGRQHADRVALAGAAVIHPVTRVLGPLPRLLILLGNALTPGKGFREGPFASEAELRDLVDLAEQRSLIEPDEREMIHSVFELGDTLVREVMVPRTDIVFIERDKTLRQALSLALRSGFSRIPVVGENEDDVVGIAYLKDIIRRSHEYRDGESVELVESVMRPATYVPDSKPIDALLREMQARQIHVAIVIDEYGGTAGLVTIEDILEEIVGEIADEYDVEAPRVEWLADGSARVTARLSATELGELFDVDIDVEEVDTVGGLLAYALGRVPIEGSTAAVRGLELKAESIAGRRNRIGTVLVRRQPAEPSGDRPGDPERLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BND0</accession>
    <name>A0A1H6BND0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CubicO group peptidase, beta-lactamase class C family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62184">
        <property type="protein sequence ID" value="SEG62184"/>
        <property type="gene ID" value="SAMN04489712_107279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG62184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="399" mass="41824" checksum="65AB539B479D2D4D" modified="2017-01-18" version="1">MTTHQTPVQGHCDPAFKAVRDRFEESFARGREVGAAVTVYAGDRLVVDLWGGVADHRTGRAWLPDTPCVAFSCSKAVTATAALLLAERGAYDVTGPVTDWWPEFGAHGKEGVTAEHLLSHQAGLPAFAGPVSAQEAADPAAMAALLAGQAPEWTPGEAHGYHALTFGWLAGEIVRRHAGRSVGEFVRDEFAGELDLWLGAPPEVIERAARLTARRSAAPQDPGPRADDPRPVRKDGAVLARLAQAAADPAGLLNRATNNPDPGKGGYNNPVVLAGGWPAAGMVTTASALAGFYRDLVAGRVLKHDTLRDALRRRVHGPDRVMVEDTSFGLGYMRPAASFFTPPAGVETAFGHSGASGATGLGDLEAGIAMAYIPNLMGGALSADLRAYRLVEAVYASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYW1</accession>
    <name>A0A1H6BYW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65899">
        <property type="protein sequence ID" value="SEG65899"/>
        <property type="gene ID" value="SAMN04489712_108147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="20492" checksum="90EF08E06F96D8EA" modified="2017-01-18" version="1">MRRVRRPGIGHTAGMDEAPADIAEIERALDRVSHLLTRARRHGRTVAEAGVPVDRAAVPVLRLLADAPGPLRPGELAVRLAVEAPHVTRQLQRLEKAGMVERVPDPRDGRAHRVRLTDAGRAAVDRIRAVSRRWMAEALADWPVPERRLFAALLHRMVDDFLAHAAEHGTLGAEPRRPCCDDGLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C025</accession>
    <name>A0A1H6C025_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="9">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_108182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:18179"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:10242"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66319">
        <property type="protein sequence ID" value="SEG66319"/>
        <property type="gene ID" value="SAMN04489712_108182"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050343">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG66319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="27430" checksum="C48AC647F2C4E088" modified="2017-01-18" version="1">MGLLEGKRILVTGVLTDASIAFHVARLAEAEGAQVVLTAYPRPTLTERIARRLPSGLAGDPPPVIELNVTDRDHLDGLADRVREHVDGLDGIMHAVAFAPETALGGNFLDTPWEDVATAMHISAYSLKSLTMACLPLMKDGGSVVGLDFDASVAWPVYDWMGVAKAGLESTARYLAKYLGPQGVRVNLVAAGPLGTMAAKSIPGFHEMRDIWPEHAPLGWDVADPEPTARACVALLSDWFPATTGEIVHVDGGVHAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2M3</accession>
    <name>A0A1H6C2M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66895">
        <property type="protein sequence ID" value="SEG66895"/>
        <property type="gene ID" value="SAMN04489712_108234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294374" evidence="1">
        <location>
            <begin position="30"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="445" mass="46921" checksum="EE6C8BFC8C66A20C" modified="2017-01-18" version="1">MRAERRSMGRRRMLGVTLAAGLAISTAAACGGDDTDTGPEGGGALKGQTVTVAAIWTGTNEGAKFKKVLDAFGKRTGAKVIYTPTGDNVAAFLGSKVNGGAPPDVAFLPQQGVLVEFAKKGWIKPLPAEAQSELQKNFAKVWQDLGSHDGKTYGIYYKTGSKSTIWYRKQAFTDAGIAQPPTTWADFVKTAQTLSDSGATPIAIGAADGWVLTDWFENVYLSVAGPDKYDQLSKHEIKYTDPTVKEALRRLAEIWGKQNYLAGGPKGALQTEFPGSVPQVFGASPKAAMLPGADFVASEITSATKSKVGTDADFFPFPAAGATAPVVGAGDAAVMMKDTPGARELLKFIATTEAARIWAEQGGYISPNKSLDLAAYPDEVQRRIAKAVIDAGDDFRFDMSDLAPAAFGGTKGAGEWKILQDFLADPSDVDGTAAKLEQAAADAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C330</accession>
    <name>A0A1H6C330_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferases group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_108254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67107">
        <property type="protein sequence ID" value="SEG67107"/>
        <property type="gene ID" value="SAMN04489712_108254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="179"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG67107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="368" mass="38932" checksum="40A427CBEACEEE1D" modified="2017-01-18" version="1">MNAATARSVHVVLPGDVDDLTVPSGGNVYDRRVCRGLAASGWQVHEIPVPGSWPRPDETTRAELVRALTALPDGTVVLLDGLVACGVPEVVVPQARRLRLAVLVHLPLADETGTAPQVVEELDSRERVTLRAATVVLATSPWAGRRLVDRHGLDPGRVHVVPPGVDPAPLAPGTDGASRLLCVASVTPRKGQDLLVRALGSVGDLPWSCVCAGPLRRDPGYVGRLRALIGTLGLGDRVRLAGPYTGGRLAALYAAADLLVLPSRAETYGMVVTEALARGIPVLATAVDAVPQTLGRAPDGGVPGLLTPPEDPRALADALRRWLGEPALRRRIKTAARARRDTLDGWETTVHRLGNVLDELLRRPLKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9J3</accession>
    <name>A0A1H6C9J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69578">
        <property type="protein sequence ID" value="SEG69578"/>
        <property type="gene ID" value="SAMN04489712_10998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294602" evidence="2">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG69578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12702" checksum="981B6E468A97C6F6" modified="2017-01-18" version="1">MLKRLAAASVLTVAAGGVLVSAAPAMADTRRNQDPQIYDNSNNVLVNCPDGSRSNPRGSSYQGSGDDFRSEFREMFRGMEFLFPAVFDGSDDSDRGRVSRSASSGCKQVNYIVNQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CD00</accession>
    <name>A0A1H6CD00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70778">
        <property type="protein sequence ID" value="SEG70778"/>
        <property type="gene ID" value="SAMN04489712_109203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294707" evidence="2">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG70778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="6664" checksum="C416741208EABAF0" modified="2017-01-18" version="1">MTDRLRRLLLTGVAAALLAGCTTDPATSGPASPQGGTTMPAELERIVTDAERAAQDGEQDLREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CES1</accession>
    <name>A0A1H6CES1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase/secretion neighborhood TadE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71454">
        <property type="protein sequence ID" value="SEG71454"/>
        <property type="gene ID" value="SAMN04489712_109272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021202">
        <property type="entry name" value="Rv3654c-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03816">
        <property type="entry name" value="tadE_like_DECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294764" evidence="1">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="109" mass="10938" checksum="265279B3891B8992" modified="2017-01-18" version="1">MLAFVALVWVFSVTVVSAGAVRVARHRAYGAADLAALAAASRAAEGSAVACRRAAVVAEGVGGRLSSCVVRGAVADVEVLVAVRLPAPVGRVRFVSRARAGPQALNGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKB0</accession>
    <name>A0A1H6CKB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, DUF58 family, contains vWF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73187">
        <property type="protein sequence ID" value="SEG73187"/>
        <property type="gene ID" value="SAMN04489712_11081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="197"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="41425" checksum="4F814463EA052D49" modified="2017-01-18" version="1">MPTRRGLLVAVAGAVLLAGGLAFGYREPVLLGALALLTVASAVAMVGRPVRLRVRRRIPTVRVTGGTTITVTLEAVVEPSGGTARPDAGTPGRAGRRSLVAAEWIAGPGGRVRRALPDLRGGSGQVSYELAAERRGVLDIGPLEAGRIDPLGLAATVRRHGETTRVWVHPKVHPIRTVPAGLMPDPDGQGDAVQAGGLTFHGLREHVPGDDLRQVHWRSSARHGRLMVREYVDTSRPRIVVLVDERAAGRDTLDQVAEAAASVLATAVRAGLTCELQLCGGRRADGRAGPSAMLDLLAEMEPAAPGSAGGSAAHPGLARACRLLRMRPAADVAVLIGATLGDADLALFGELRDCYRGLVAGIVGGRPRAAVPGVLLLAGQDAGEFATRWDEVREWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKP5</accession>
    <name>A0A1H6CKP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized short protein YbdD, DUF466 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73564">
        <property type="protein sequence ID" value="SEG73564"/>
        <property type="gene ID" value="SAMN04489712_110126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007423">
        <property type="entry name" value="Sel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04328">
        <property type="entry name" value="Sel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG73564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="78" mass="9264" checksum="29C46E39B92014FB" modified="2017-01-18" version="1">MTAPPRPLGQAAGQVRARLAERLRTAWLLLREFSGERAYEIYLEHHHRHHPGEPVMSEREFWRHHIDSRDRNPRATCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNE7</accession>
    <name>A0A1H6CNE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple sugar transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_110208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74277">
        <property type="protein sequence ID" value="SEG74277"/>
        <property type="gene ID" value="SAMN04489712_110208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG74277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="33989" checksum="71653749FFADDB3E" modified="2017-01-18" version="1">MTVLQSRPGGRRTGRRRPGLAVRRNLTAYGFLSGALICFAFFSWYPMVREFILSFQKNNFVDPPVWVGLDNFRTVIQDPAFKSAWLNTAMFTLLALVCGYLVPFVIALVLNELRHARGYLRFVVYLPVMLPPAVSVLLFKWFYDPGPGLFNQILGLAQLPALSWLDSKDTALISLVIVSTWMNLGSGTLIYLAALQTVPGELYEAAELDGAGVLRRIWHVTIPQTRLILLVMLLLQVIATMQVFVEPYLLTGGGPEDATISVVYLMYQYAFNYGNFGGGSALGLMLMLVLVVFSAAYLRLSRDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNS7</accession>
    <name>A0A1H6CNS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport system inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_110227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74437">
        <property type="protein sequence ID" value="SEG74437"/>
        <property type="gene ID" value="SAMN04489712_110227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG74437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="195" mass="20795" checksum="360185280F34A101" modified="2017-01-18" version="1">MLSAVFFVPLLMSNAAVALLWQSLLDPNFGLAGLIGPLLGASDGNVLGDPGRALAAMVLVVSWQFIPFHMLLYQAATRQIPRSLYEAAAIDGAGRVRQFWSITLPQLRHTIVSSSVLILVGSLAYFETILLITGGGPGTATRVLPLHMYLTGFSAFEMGYASAWAVLLVAAGTALSIGIVRLTGYSRMDSRREGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CS68</accession>
    <name>A0A1H6CS68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-related sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75627">
        <property type="protein sequence ID" value="SEG75627"/>
        <property type="gene ID" value="SAMN04489712_11165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="80"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="19176" checksum="73F12018A8624D75" modified="2017-01-18" version="1">MSEAIAPSTEPSAGQSGAVASGSGSPIGSGSPAPLAPAAGFASAVTAAPAASPAEAVAHFTARLAFETDVSDVAADLAAGVPGVVVVDTRDGRGWDQGHVLGAVHIPTRDIAARAPDLIGRDVTVVVHCWGPGCNGATKAALEFARLGYAVKEMIGGFEYWAREGLPVQTGSGEVVRHAPDPLTGPVVGAACAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV96</accession>
    <name>A0A1H6CV96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76613">
        <property type="protein sequence ID" value="SEG76613"/>
        <property type="gene ID" value="SAMN04489712_111186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="237" mass="25523" checksum="6976176CE8F655E7" modified="2017-01-18" version="1">MAVVIPAKDEGDRIAATVKAAAELPGVDLIVVVDDGSSDSTGRLAAEAGARVVRHSRNRGKGAAMESGAEAVRLLDEGREEPRHLLFLDADLADTAREAVPLVEPVRRGEADMTIATFTTTVKLGGHGFVVRLSRDGIRRATGWEATQPLNGQRCLTRAAFEAGLPLAAGFGVETALTIDLVRCGFRVLEVEVPLAHRATGTDWKAQLHRARQFRDVARALAAREPMIATRLAHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CW41</accession>
    <name>A0A1H6CW41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77078">
        <property type="protein sequence ID" value="SEG77078"/>
        <property type="gene ID" value="SAMN04489712_111245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG77078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="58" mass="5829" checksum="2751AE85AA288C00" modified="2017-01-18" version="1">MLAQREIAGIGVGTDAADIGALMVEPETAISDAPVFTPNGALLLLAAVLLSPKGPKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CXX1</accession>
    <name>A0A1H6CXX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78009">
        <property type="protein sequence ID" value="SEG78009"/>
        <property type="gene ID" value="SAMN04489712_11214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295334" evidence="1">
        <location>
            <begin position="33"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="189" mass="20954" checksum="23521F3E310833EF" modified="2017-01-18" version="1">MRITRNIRKIGLTMAAAAAVVSVGTVATPAHAETFYNIKVQHSGKVLTAERVSGTVLAGARVIQTTPNPFNRDAQWFIRPQPGEHIETYELRDDILTPDGHRVRGCISLTHIVLNNTPLIVLPCNGSNRLKWKYTHVGDDYYEINTVRGNGEWYWHIQNASTVENAPLVEFSGPGGSNARFYWDPVGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2H3</accession>
    <name>A0A1H6D2H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78856">
        <property type="protein sequence ID" value="SEG78856"/>
        <property type="gene ID" value="SAMN04489712_112133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="41242" checksum="287CAB233205A53F" modified="2017-01-18" version="1">MAVPGIREGVVRESGPSDHALARTVLRFAIALRCGGVTAAIIAASVSDGTGISRVWQVLVLGGLALWAVFFTVVAVRHGLRFPLVAGDTAVVALALLAQPRFIPVSAVVDESTWAIMLASTAIYVAQLSLRPAAGLPLALTVIVAYMVGVPVSTSQVRVLFVQAGVVSAMMELLRRGGRRADAIVADRDRERQRVMVEAARRADERHQRLQMHDSVLAVLSMVASGAMQADSPGLRRGAQQALDVVEEFAAPPASDGGVLVDLVGGLRKLVTEMSSRLDIEVAHHEAARIYVPESVALAVIGAAGEALRNIERHAGVARAVVRAERQGDLVTVEITDRGLGFDPDRLPDDRHGIKRSIVERMKVVGGSAAVWSRSGEGTRVTLRWPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4Q6</accession>
    <name>A0A1H6D4Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class probable F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80349">
        <property type="protein sequence ID" value="SEG80349"/>
        <property type="gene ID" value="SAMN04489712_11366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="16070" checksum="6E0FD6522240C2C3" modified="2017-01-18" version="1">MADDAALQKLLQERNLGVLATIKRDGRPQLSNVTFHYDPDRSLIRVSITADRAKARNLARDPRASLHVTTPDGWAWAVAQGTADLSPVAADRHDAVVEELIDLYRAVQGEHPDWDDYRRAMVEDQRRMVRLHVEHLYGQPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6C6</accession>
    <name>A0A1H6D6C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80343">
        <property type="protein sequence ID" value="SEG80343"/>
        <property type="gene ID" value="SAMN04489712_11365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="236" mass="25742" checksum="0D5D071245AE4B1E" modified="2017-01-18" version="1">MNDLAENLAENLSQEPAGRDDQLVYRLLVAVDIQGYSKRDTREQLHAQRDLSQALDRAAAGAGLDRARWDKQVGGDGELAMLPEDADLAPVVGDFPLLLAAGLRALNRERSGRPRLRIRLAVHHGTLTAGPFGPAGDAPIVVQRLLDAVPLRRLLADEPERDLAYMVSDSLYADVVRTGFTRMAPGDFQAVKVTAKGAAYRGHIHIGDPIVFADLGELHDRLPAMPPLVPSQRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6P0</accession>
    <name>A0A1H6D6P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80754">
        <property type="protein sequence ID" value="SEG80754"/>
        <property type="gene ID" value="SAMN04489712_113146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="240" mass="25766" checksum="7A083B8E9186A02D" modified="2017-01-18" version="1">MDVIRLTTDLYFLRFPVGHVYLWRDPDGLTLIDSGAPGSGPQIAEAIRSLGHRPSDVRRLVLTHGHVDHVGAAAEIAAWGEVTVYAHRAEAPIIRGEAPEPPPNLADWERPIFERANAGLPPGRPEPVRVDRELDDGDVLDFGGGAHVVPVPGHTDGSIALHLPGPRVLFTGDLAARDPQSPDPQTPIILGVFNLDTAEAATSFKRLATLDTEIACFGHGEPVTRNATAHMQATAERLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6X1</accession>
    <name>A0A1H6D6X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80495">
        <property type="protein sequence ID" value="SEG80495"/>
        <property type="gene ID" value="SAMN04489712_11392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="361" mass="38669" checksum="4522499C4F8FD0EA" modified="2017-01-18" version="1">MTDEAREPGGREAGIEVVQAGDPVAVRSCAGCGRPVPQPVGGRVVRYCPDGGGACQRDARERRARGRDGSGLTGQVALAWDMVERLEKTADALAGSLAGELSVAGVERRVAEAHAEAARLVAVAQEEREASQRQAERAWREAAAARSRTLAAEQEAAQAREEAEEAIAERDRANEIALEARRAAEEAIAERMAAGKERDHLAAREGDLLAALESARAELVGVHARLADSEAAAQAQRAEAAAARRAADDLRAALKDAEAQRGRAVADRDQMQARLQEQDKRTWELSRTVAELRTALAALVNERDAARAEADRARRQIDAYTRDSLAGHDVPAARQGAGDRVTRIEDSPAGLHSINGFRQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D706</accession>
    <name>A0A1H6D706_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80583">
        <property type="protein sequence ID" value="SEG80583"/>
        <property type="gene ID" value="SAMN04489712_113107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="296"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="384" mass="41103" checksum="F086615BED70635E" modified="2017-01-18" version="1">MRVTAIVLRALIGLVLGAVTAVVEAVFLVLAALGFAYSFVSSRGERAVPRMVGTVAGWLAEVERKRLEIFLRVDGVPGGYPPLRALAYLVLRVPVGLLGGAVLLLLVYGLALAALLLYWWTTGTYPPDYGPNAERLLAAAGVGGVLLFLDLQGLVGIAALERRLVRSCLAPSSRQAYEQRIAQLSTSRAEVVDAIDDERRRIERDLHDGVQQRLVGLSMLIGRARRARDPDRAADLVRQAHEEAQRALEDLREVSWRVYPAALDADGLRAALETVAERSAVPVTIDYTAGRRPPGRVETAAYFVVCEAVTNAAKHARAERVTVQVSQEGIMLRVRIEDDGIGGADPTGGGLAGLTRRVAALDGRLGVDSPLGGPTVITAELPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7F4</accession>
    <name>A0A1H6D7F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80436">
        <property type="protein sequence ID" value="SEG80436"/>
        <property type="gene ID" value="SAMN04489712_11380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035172">
        <property type="entry name" value="DUF5302"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17227">
        <property type="entry name" value="DUF5302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="6758" checksum="854C8AE4A88376AF" modified="2017-01-18" version="1">MAEKATEPEGAEDDMKRKFREALERKRGSHTDSGGGAGGKGPAKVHGGAHGPAKGQRQFRRKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D920</accession>
    <name>A0A1H6D920_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81343">
        <property type="protein sequence ID" value="SEG81343"/>
        <property type="gene ID" value="SAMN04489712_11430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="130" mass="14852" checksum="0570CC9BACC83EAF" modified="2017-01-18" version="1">MGDTTWKTAAASTDPEQACPIAPVVDIVFSRWTTPILWTLNQHGRQRFVELQRRITTITPKVLTQRLRQLERDGLIVRTYHPEVPPRVEYEISDLGRSLAPLFAHLAEWAAVNLDKVDRARHAYDNASAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DES3</accession>
    <name>A0A1H6DES3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Poly(A) polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_115136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83066">
        <property type="protein sequence ID" value="SEG83066"/>
        <property type="gene ID" value="SAMN04489712_115136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HDc" evidence="4">
        <location>
            <begin position="268"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG83066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="488" mass="54231" checksum="D7E0037BE74B0E04" modified="2017-01-18" version="1">MPVPNAAPSEEPTPQQRQAIAELLRRVIPPTADELGRRFAAAGHELALVGGPVRDALLSRPGKDVDLTTDAFPEQVLQLVEGWADAVWTIGIEFGTVGLRKGDLQLEITTYRSESYDPKSRKPDVAYGTSLVDDLARRDFAVNAMAARLPGHEFVDPFGGLADLRRKVLRTPGRPEDSFGDDPLRMMRAARFAAQLGFTVAPEVVRAMREMAGRIEIVSAERIRDELSKLVCSAHPREGLALLVDTGLAEHVLPELPKLRLEIDEHHRHKDVYDHSLIVLEQAIAQEERGPDLVLRLAALLHDIGKPKTRSFEAGGRVTFHHHEVVGAKMARSRLTALRYPKDVVADVSRLVELHLRFHGYGTGEWTDAAVRRYVRDAGHLLPRLHKLTRADCTTRNKRKADRLRRTYDGLEARIARLAEEEELAKIRPELDGNEIQAVLGITPGPLVGRAYKHLLDVRLDQGVIGKEAATAELLRWASEQGLEPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHS1</accession>
    <name>A0A1H6DHS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_117104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84977">
        <property type="protein sequence ID" value="SEG84977"/>
        <property type="gene ID" value="SAMN04489712_117104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG84977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="233" mass="25763" checksum="0BF05DFBCE708306" modified="2017-01-18" version="1">MKEATDVISGEGSGGRAGAGPAGGSAGARRPGPREIRRRQRIELGREQLLQTAEELFAKRGYYETSLKDVAEMCEFSVASIYTFFDNKEDLYLAVLMRRGAWQREEMGRLAAEEMSAADRLVAMVRAQIEHRRKYPAWGQLHAQMTKIGGRGTGDVPAVYREFYHEIVGLLAGVIAEGQHEGTLRPGDPHALARLCSALIDSFTLMDPVISDEPEGIDAEDFLNFIRETFTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJ30</accession>
    <name>A0A1H6DJ30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase AhpD family core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_117151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85159">
        <property type="protein sequence ID" value="SEG85159"/>
        <property type="gene ID" value="SAMN04489712_117151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="177" mass="19949" checksum="1396027B507E9C4A" modified="2017-01-18" version="1">MTPRLPPVPYEEWDFEALSIIMPPGRKPPPSNMLGMFAHHPRLAKAFLRYNNHLLFRSSLPARDKELAILRVAWRRRCRYEWAQHVIFAREAGVTDEELAGIRTGADTLINRAVDELEEAGALSEATYAELAEGYDTHQLLDFVFTVGTYGLLAMACTTFGVELDPGIPDENFDSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJI3</accession>
    <name>A0A1H6DJI3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_11832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85557">
        <property type="protein sequence ID" value="SEG85557"/>
        <property type="gene ID" value="SAMN04489712_11832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="34"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG85557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="284" mass="29386" checksum="300E0A9C868B3953" modified="2017-01-18" version="1">MTTVARPPGTATRPSGALSFEGTAGWQGTGTAAQIGVLTARLMRTLVLDRRVLAVGVLEPLVMLVAFGQVFAGLAHSPGFPPGVRYLDFLLPALLLTTALQSGVQAGMGIVDDTRTGLLTRLRSMPVRPGSILAAHGLACLVRGALRLFLLLVLAWSLFGHRPPGGPAGVLAAAVLCLVIGWSLGWVFLALACWIDRVELLQATTGLVMFPLMFASNAFVPVGALPTWLEWIARLNPVTYGVDAARDLCLTGATGPGALAAAGIGLAIAVSAAPVAVRGLARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJR2</accession>
    <name>A0A1H6DJR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85482">
        <property type="protein sequence ID" value="SEG85482"/>
        <property type="gene ID" value="SAMN04489712_11814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021678">
        <property type="entry name" value="DUF3263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11662">
        <property type="entry name" value="DUF3263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="105" mass="12397" checksum="9BF2BBB6C71ADB5C" modified="2017-01-18" version="1">MDDGSALQPVSDAPGDDVAFPADLLSERDRRILAFERQWWKYAGAKEQAIREEFDMSATRYYQLLNILIDRPEALEHDPMLVKRLRRMRTQRQRRRAARRLGINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJR3</accession>
    <name>A0A1H6DJR3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85478">
        <property type="protein sequence ID" value="SEG85478"/>
        <property type="gene ID" value="SAMN04489712_11813"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="PTHR43768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG85478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="277" mass="28216" checksum="409E1718C773268C" modified="2017-01-18" version="1">MTSPSLKPLTSAGDDGLAALRKAPGDAVLGLDFDGTLAPIVEDPAQARAHPAAAPALARLAPLVGVIAIVTGRPAAVAVEHGGLEGVDGIVVLGQYGLERWEGGELTVPEPPPGVAEVRAKLPALLAAAGAPEGTHVEDKGHALAVHTRRCAEPQVALDRLRGVLEALAERTGLQAEPGRYVLELRPSGMDKGVALRGLLAERARPGFPSVVLYAGDDLGDLAAYAAIDELRAQGVPGVKVCSGSTEVTALAEQADLVVDGPAGVVELLDRLAAMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DK04</accession>
    <name>A0A1H6DK04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85582">
        <property type="protein sequence ID" value="SEG85582"/>
        <property type="gene ID" value="SAMN04489712_11838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="175"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="356"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="459"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="808"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG85582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="925" mass="102798" checksum="3844DDF9EA8A1F22" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DM00</accession>
    <name>A0A1H6DM00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86330">
        <property type="protein sequence ID" value="SEG86330"/>
        <property type="gene ID" value="SAMN04489712_11955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG86330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="28648" checksum="2A6125058074E50C" modified="2017-01-18" version="1">MTELVNISGLSITARLSHGDLRLLEDVDLDIGRGEVVGVVGESGSGKTTLARSVVGLLEKNVRVDGGSISLAGEQIIAPGVDRTGRVRGTAVGMVFQDASRSLNPLMKVRAHLAEVLRRHVRGISRNDIERRSVEVLEQMRITDAKRVLDSYPHQLSGGLRQRVAIGLAVVTRPSLVIADECTTALDVTTQTKVVELFRSLVDELGIGLLFVTHDLMLASDLCDRIAVMNSGRVVEQGPAMEVLDRPRQDYTQRLLRAIPTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP33</accession>
    <name>A0A1H6DP33_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ORF">SAMN04489712_12053</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87018">
        <property type="protein sequence ID" value="SEG87018"/>
        <property type="gene ID" value="SAMN04489712_12053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="31"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG87018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="25136" checksum="956B696B49033664" modified="2017-01-18" version="1">MRRPPRFTPRRDAGLYGLERALEHAGFRPVAGVDEAGRGACAGPLVIGAAVLPSGRRGVIDGLTDSKLLTPRRREEIYAEIVDRAAAWTAVIIPRHDIDRIGLHRCNITGMRRALAKLETRPAYVLSDGFRVPGLDVPGLAVPKGDRVAACVAAASVIAKVTRDRLMTELHERYPEYGFAEHKGYITREHTAALGVYGPCPEHRLSFVNVARLRDNGAEAGAFDLAGEGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPD2</accession>
    <name>A0A1H6DPD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87159">
        <property type="protein sequence ID" value="SEG87159"/>
        <property type="gene ID" value="SAMN04489712_12079"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="6">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG87159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="27489" checksum="3A14CA288D09854E" modified="2017-01-18" version="1">MNHTPAAAPARVLTVAGSDSGGGAGIQADLKTMLALGVHGMSVITAVTAQNSLGVQGYWELPPEAVRAQLDSVLSDIGAQAVKTGMLASPVLVEIVAEMLAGLEAPVVVDPVGVSKHGDPLLAPEAVHAVRTALLPAATVATPNLWEVEQLTGVKVVDEAGMREAAEAVKALGPRWALIKGGHLPGEPADLLFDGEREYRFSAPRHDNRHTHGTGCTLASAIASHLALGEDVPTAVRLAKEYVTGAIAAGFPLGAGIGPVDHGWHLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPZ4</accession>
    <name>A0A1H6DPZ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetaldehyde dehydrogenase [acetylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_120114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:23288"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the acetaldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87338">
        <property type="protein sequence ID" value="SEG87338"/>
        <property type="gene ID" value="SAMN04489712_120114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01657">
        <property type="entry name" value="Ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003361">
        <property type="entry name" value="Acetaldehyde_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015426">
        <property type="entry name" value="Acetylaldehyde_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09290">
        <property type="entry name" value="AcetDehyd-dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015689">
        <property type="entry name" value="Actaldh_dh_actl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03215">
        <property type="entry name" value="ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="156"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG87338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="298" mass="31412" checksum="5CF3B2E837DC2D29" modified="2017-01-18" version="1">MTATAAIVGPGNIGTDLLYKLLRSRHIEPRYMVGVDPDSEGLKRAAELGLETSHEGIDWLLARPEKPDLVFEATSAYVHRAAASRYREAGIRAIDLTPAAVGPAVVPPANLREHLGADNVNLTTCGGQATIPMVYAVSRVVPVEYAEIVASVASLSAGPGTRANIDEFTKTTARGIETIGGARRGKAIIILNPADPPVIMRDTVFCAIPADADRDKITESVLDVVGRVSGYVPGYRLRAEPQFDDPAPETGGMARVAIFLEVEGAGDFLPPYAGNLDIMTAAATEVGEVLAQEIEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTL3</accession>
    <name>A0A1H6DTL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88569">
        <property type="protein sequence ID" value="SEG88569"/>
        <property type="gene ID" value="SAMN04489712_12233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="6633" checksum="C01E6076C50D6B68" modified="2017-01-18" version="1">MTAGSADGTVHTGAARANERALCRGSMFDRFGRLVAGVTHEGLIRVRPGEGRPSPLAGSGKECH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTL7</accession>
    <name>A0A1H6DTL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88590">
        <property type="protein sequence ID" value="SEG88590"/>
        <property type="gene ID" value="SAMN04489712_12238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="27870" checksum="5D2EEEBA6EED2793" modified="2017-01-18" version="1">MTGEPRCEISGDLLRITLARPDKANAMRGRDMAVVLEALEAVAAGRTARAVLIEGEGRNFCAGADLVSANPPGGDRPPIGTMVRSLNTVAHRVIQTLWDLPVPTVAAVQGRAAAFGLNLALATDFVVAAESATFGYPFAQRGFTADSGATYLLPRLIGVARAKQMLIRGTVVTAPRALEWGLIGEVVPDGELTEAAARLAVELAAGPTFVHGLTKAMISDHLTSDLPRALAAEARTVELSLRGDDFKEGIRAFLGRRPPRFTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUU2</accession>
    <name>A0A1H6DUU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-related amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88814">
        <property type="protein sequence ID" value="SEG88814"/>
        <property type="gene ID" value="SAMN04489712_12285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="22039" checksum="1B2A6E5D4A5C299F" modified="2017-01-18" version="1">MSAWIAQTRERYEQGGLAGRLTWGRRPAVVVVDLQAGFTDPACPPGSDLDDVVARTAEVVERATAVGAPVFLTTIAYPPEELDRLVWLRKMPAMRALTEGSKWVEIDERLPVREPVIVKKAASAFAGTDLAGRLAAERVDTLVVCGATTSGCVRATAVDACAANLAVFVPRECVGDRAPGPHEASLLDIDAKYGDVIGVEEVLARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVC6</accession>
    <name>A0A1H6DVC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88535">
        <property type="protein sequence ID" value="SEG88535"/>
        <property type="gene ID" value="SAMN04489712_12225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="15"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG88535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="490" mass="52422" checksum="21A4622369549207" modified="2017-01-18" version="1">MSADLIRRLYIDGAWTDGDGDERIDVVNPATEQVIGQVPQATRSDVVRAIEAARRAFDEGPWPRMSVRERAQVMLRMADVMERRMPEIVELNIAEAGSIRPLAESIQVGIPIQHLRDMAERVMPAFAWERPVAPFVGQGIGQGVLRREPFGVATLISAYNFPFFLSVMKLAPALAAGCTTVLKPAPTTPLESLILGEIAEEAGLPPGVLNVVTGDIAAGQELTTNPMVDLVSFTGSDTVGRMVYGQAASTMKKVVLELGGKSPTVVCEDADLDKVLPEVLAGITVHAGQGCALFTRTLVHRSRHDELVEKVVAALQYVKVGDPAEPATLMGPLISQAQRDKVEKLIRTGEEEGAHLAFGGGRPVGLERGYFVEPTLFTGVDNAMTIAQTEFFGPVGVVIPFEDDEDAVRIANDTSYGLAGSVWAADPVRAYEIAKRIRAGYVAVNGAGGGLSPHLAFGGYQQSGLGREWGEHGLDEYLQTKSIAWGVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVY5</accession>
    <name>A0A1H6DVY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphonopyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89418">
        <property type="protein sequence ID" value="SEG89418"/>
        <property type="gene ID" value="SAMN04489712_12388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033980">
        <property type="term" value="F:phosphonopyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032923">
        <property type="term" value="P:organic phosphonate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017684">
        <property type="entry name" value="Phosphono-pyrv_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03297">
        <property type="entry name" value="Ppyr-DeCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="2">
        <location>
            <begin position="213"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG89418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="373" mass="39691" checksum="E9A168C7A2486DC0" modified="2017-01-18" version="1">MIDPVECCRRLKLHGCTYFSGVPCSYFASLLQALDLDPGMRYVEAANEGSALATAAGVALAGGRPVVVLQNSGLGNLVNPLTSLSAVFDLPALLLVSWRGCPDEPADEPQHRIMGAATPRLLRLLQVPYWLAPPDTEKFNDVLEAAVQTMLRSQRPVALLFRRGTFSPVEPAGVPPAVGGFTRRDAVAVITRKLTDRDALVATTGMISRELFRQRDRPANFYMQGSMGHAGAIGLGLALKSPGRRVVVVDGDGAAIMHLGSLSVIGSTMPPNLVHIILDNAVYESTGGQRTSAARTDFSAVGRACGYRQAHQCSDAAALAAVLDGAAHSAGPTLIHVKITPDSGTKPARVATELLPREVKERFRKALREDIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DW17</accession>
    <name>A0A1H6DW17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89389">
        <property type="protein sequence ID" value="SEG89389"/>
        <property type="gene ID" value="SAMN04489712_12382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="238"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG89389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="460" mass="49811" checksum="600E05E3DE4DD6FD" modified="2017-01-18" version="1">MSETPPPGVPARGTDPLDFSVSGTYPLDFSMSGTYPLDFPASGTYPPETVKSPVGKGFRGPAFPPGGYRLSSDRPRFTGALEALVGVENSPQVSRPAVPALRHGRGPLGHPAPEWADDLPDGLLVADARARVVVFNRAATRLTGIAAEAALGRDFRDVLPLHDAEGRDWWKCLDPYGGLATRTRHPERPLFLAGGTELLVAASYRRRPDRSVERFTISFRDAARRARQERDRADLVSTVAHELRSPLTSVKGFTATLLAKWHRFNDDQKRVMLETVNADADRVTRLITELLDVSRIEAGRLEMRRQVVDLAEEARKVIAGRVAAGDPADRFRLIAADGLPEMWLDPDKIDQILGNLLENAVRHGAGTVTIVIERVNAADGPGAVVSVRDEGEGIPPEAAQRVFRQFWRGPGGNRRGGTGLGLFIVKGLVEAHGGTIAVRRAPGGGAEFRFTVPAGTPDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DW22</accession>
    <name>A0A1H6DW22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_12398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89461">
        <property type="protein sequence ID" value="SEG89461"/>
        <property type="gene ID" value="SAMN04489712_12398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="148"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG89461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="310" mass="32450" checksum="6D652FC07DEB38EF" modified="2017-01-18" version="1">MVRHFLRDDDLTPAEQAEVLDLAAAMKRDRFAHRPLEGPRTVAVLFDKPSTRTRISFAVGIAELGGHALVMDAGTSQLGRGETIGDTARVLERQVAAIVWRTGGQQRVEEMAAASSVPVVNALTDEFHPCQILADLQTVQEAKGTLAGVTLAYLGDGANNMAHSYLLGGATAGLHVRIAAPEGYTPDPAVVGRATEIAGSAGGSVTVTTDAKAACQGADVLATDTWVSMGQDAKDVAVFAPYAIDEEKVALAAADVSVLHCLPAYRGKEIAATVLDGPHSVVWDEAENRLHAQKALLTWLLERSAGGGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXE8</accession>
    <name>A0A1H6DXE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator YbjK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90022">
        <property type="protein sequence ID" value="SEG90022"/>
        <property type="gene ID" value="SAMN04489712_12516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG90022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="21167" checksum="CD3BFFE6E539B241" modified="2017-01-18" version="1">MSGPAASRPPAARRPRRHDPGRRDRLIDAARTVIAERGVAGTTHREIARVADVPLGSMTYHFASLEEVLIEAFTRHADAVAGVFDERLEAAWDRDAAIEAVITLVSEDLLGSQHDLVLTVELYVAAARNPALRAVTQAWMQRSRQALERHFDATTARELDALIEGLVLHSALSTDPMTPEQIRHAIHRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY28</accession>
    <name>A0A1H6DY28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89656">
        <property type="protein sequence ID" value="SEG89656"/>
        <property type="gene ID" value="SAMN04489712_12418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296311" evidence="1">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="24418" checksum="1F4C2EC143A794D8" modified="2017-01-18" version="1">MKRTAVLVAVTAALLGLAARPATAAAPTPSDADFADCPALPAGAVAGTWKCHTMTAEDTLIGVSIGRMHAHTQEPVRLTIAQGRLTDGTTVAKLGGLRAEPIPFVTGVPGTRWEVPHPTGWKLEITPTGLVEPGALVPHTVGLTARIIGDDLGGSCTIGSAAKPIVIEPVVDWALPWMSGGTLVTRMKVADITYALGLATGCNGHEFAVNQVLGLPANAASNQFVATWQYRSKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYR0</accession>
    <name>A0A1H6DYR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90500">
        <property type="protein sequence ID" value="SEG90500"/>
        <property type="gene ID" value="SAMN04489712_12657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="14844" checksum="F1130D21C0896846" modified="2017-01-18" version="1">MDRDLPGVALGADPVATAPHAEYQAQLDREVLAFQACGTCGAAVFPPRSRCPHCGRPELGWRRSRGRAVVYSATTIEPRGGEPYCVALVDVAEGFRMMTNIVGVAASDVRIGDQVTLRFERRDDTVIPVFGPAEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0S9</accession>
    <name>A0A1H6E0S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-3-methyladenine glycosylase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12731</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90763">
        <property type="protein sequence ID" value="SEG90763"/>
        <property type="gene ID" value="SAMN04489712_12731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="97"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG90763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="494" mass="53165" checksum="5BD2EEF76D7BF782" modified="2017-01-18" version="1">MKGLGLGFTQGVLDFDSCYRAVSARDPRFDGRFFTAVTSTGIYCRPICPARTPARRNVRFYRDAAAAEAAGFRPCKRCRPEACPGSAGWDFRGDLVRRALRLIDDGVVDEYGVRGLACRLAVTERHLHRLFVAELGAPPLAVARSRRLQLARRLLRETAMPVTDVAFAAGFGSVRQFNATLRETYGQTPSQLRGPRPADGSALELRLAVRPPFDAAGLLDFLAARAIPGVEEVGDGRYARTGPGPYRIELLPRDGHVLLRADAPDLRGVSRLVARCRRLLDLDADPQAVNEVLGGDRLLAPLVAVRPGLRVPGAFDGFEMAVRAVLGQQVSVAAARTLAGRLVARCGDPLPRPVGGLTHRFPAAEAVADADLSGLGLTGARERTLRELARAVASGKLDLDGGADPGETTRRLLDLPGVGPWTVAYVAMRALGDPDAFPAADLGLRNAVRNLTGDGSPADLRERAEGWRPWRAYAAMHLWASLAAPTSQRTLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1G5</accession>
    <name>A0A1H6E1G5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EAD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91199">
        <property type="protein sequence ID" value="SEG91199"/>
        <property type="gene ID" value="SAMN04489712_12860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045431">
        <property type="entry name" value="EAD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19956">
        <property type="entry name" value="EAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAD2" evidence="1">
        <location>
            <begin position="250"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="36411" checksum="8D4839828F6F1DEF" modified="2017-01-18" version="1">MASGSFGGRDGWNPSGQCTFFVCDIVSFTAHSRSDLAREHMRLALYAMLEDCFERADLPPGRCYHEDRGDGVMVVLPPELDSSRLVHPLIDLLRGRLLDYNDLASDVARIRLRTALHLGRAKSDGKGIVGADANHVFRLLDAPGFKAALKRSGSVLGVLASQALYDEVIRDARGLIDPDEFRPLPVANKETRATAWLRIPGEGHGGDGSQLVPADPPAAQEPRAEVRITVPGVGHGPSADLTMKELLDVVDRLLDIPLMVTAEGRDGVVESLRREIRIRVARRPQPHMDGMSIVRTCAQYPGGLLELAALVRAYAGDTPQVAALRETIARICGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2C3</accession>
    <name>A0A1H6E2C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfonate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91146">
        <property type="protein sequence ID" value="SEG91146"/>
        <property type="gene ID" value="SAMN04489712_12847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296445" evidence="4">
        <location>
            <begin position="32"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="42"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG91146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="332" mass="35435" checksum="B154434EFB505E15" modified="2017-01-18" version="1">MNRRIAALLAALTLIVATASGCGDSGEDADAATGPVDLTKVTLRVGDQKGVSIQSLLKAAGQLDGTPYKVSWSLFTSGPPILEAINAGAVDFGSVGNTPPVFAAAARSKIVIIGGTEVALDGQAIVVPRGSALKTPADLRGKKVAVAKGSSAHYHLLSVLKKNGLAFTDIQPQYLQPADALAAVSGGRVDAWAIWEPYTSQAEAQTGVRILADGKGYVNGYNFQITSRSALKDRNKVAALKDFLARFHKALLWANEHPQEWAKQWAADTGLPVEVAERAHRRRLATIIRLDDTVVAEEQRVADAFSEVRLVPGKVEIADFFDRRFNDIVSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2Q3</accession>
    <name>A0A1H6E2Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91473">
        <property type="protein sequence ID" value="SEG91473"/>
        <property type="gene ID" value="SAMN04489712_12928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="27433" checksum="AB28628E39D5B6D4" modified="2017-01-18" version="1">MNQTPFDLQGRVAVVTGGNAGIGAAVAGALAAAGCDVAIWGRDQERNRDCARRLAEHGRAVLPVACDVSDELQVERAMSRTVEELGRPDVCVANAGTAARRHPSQEYPLDEWHRVMGINLDGCFLTLRAAARRMVEGGAGGSLVAISSAAALQGMPGSPPYAAAKAAVLSLVRSLAVEFARHGIRANAVLPGWIDTDMIGDVVHGQDSRAQATREAVLRRIPARRWGRPEDIGGAVVYLASDAAAYHTGDTLVVDGGYTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E675</accession>
    <name>A0A1H6E675_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_13336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92385">
        <property type="protein sequence ID" value="SEG92385"/>
        <property type="gene ID" value="SAMN04489712_13336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG92385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="416" mass="44137" checksum="17AAFEFB48D6747D" modified="2017-01-18" version="1">MFRSLRIRNYRLFAAGQVVSNTGTWMQRVAQDWLVLELAHGSGVALGITTGLQFLPLLLFGLWGGVLADRYPKRRILMITQAAMGLLALLLGTLAITGTARVWHVYVLAFALGMATVLDNPARQTFVNEMVGRRNLPNAIALNSASFNGARVLGPAVAGLLIAVAGTGPVFLINAASYVAVLFGLAAMRRSELHPGELVPRAKGQLREGLRYVRGRRDLVMVLTLVGLVATFGMNFQMTTALVTREVFGVGASSFGLASAMLAVGALAGALLAARRVRPRLRLLLSAALLFGVLEVVTGLMPTYWSFLVMLVPTGMALMTFTTAANATVQLGVAPEMRGRVMGLYMFVFMGTNPLGAPLVGWMAEQFGPRLSIVVGGVVAALAALTVTVLAAPRGALRPALRSAIRRRPAGSAQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7N1</accession>
    <name>A0A1H6E7N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93271">
        <property type="protein sequence ID" value="SEG93271"/>
        <property type="gene ID" value="SAMN04489712_1384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796">
        <property type="entry name" value="PTHR34796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="17129" checksum="A0A5118C858B25D6" modified="2017-01-18" version="1">MRDRDELGRARNARPRDAYGRPLPHGAPGVPTMPDDLAPTPQEALTEAQRLLDADRPFHAHEVLEAAWKSAPEAERELWRGLAQVAVGLTHLRRGNPRGARALLTRAADRLDAYAPAPPHRIDVAGIAATSRELAERSDDPALATAPFMLRLRVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7U0</accession>
    <name>A0A1H6E7U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_13611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92915">
        <property type="protein sequence ID" value="SEG92915"/>
        <property type="gene ID" value="SAMN04489712_13611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="247"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG92915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="383" mass="40207" checksum="2327C4BFE590BBA5" modified="2017-01-18" version="1">MPDVAIIGVGIHRFGRFPGKPALAMGAEAARDALADAGLTWADMQFAVGGSYEVDQPDAVVAELGLTGVQFTNVYNGCATAGSALALASQTIKLGQHEIGLVLGMDKHESGAFTADPQEYGCPPWYGEMGLFLTTKFFGMKINRYMHDHGITHQTLAEVAAKNYRNGELNPNAHRRKPLTPEQILGSRMVNYPLTQYMFCSPNEGAAALVVCSADVAHRYTDKPIYLRSVVTRTRRFGAFEVHTPSASVAADHVPAPTVDAARAAFEAAGVDPADVQIAQLQDTDAGAEVIHMAEVGLCADGEQNKLIASGATAPGGSLPINTDGGLIANGEPVGASGLRQVRELVLQMRGQAGDRQVAGEPRVGLAQLYGAPGVAAVSILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8P6</accession>
    <name>A0A1H6E8P6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_14312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94110">
        <property type="protein sequence ID" value="SEG94110"/>
        <property type="gene ID" value="SAMN04489712_14312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG94110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="41385" checksum="F21557E5F15DA13B" modified="2017-01-18" version="1">MARGVIRTVDLFAGAGGLSLGFELAGKGFKPVFAVEIDDAAARTFKHNFDCHVHSGPIEDVEAFPSADVIIGGPPCQGFSPLGRDRDDVSRAQLNELWQQYLRAVHQIKPRAFVIENVPEFQKSAQFARLLQLMHTDPELKEYGYGYSVLNAADYGVPQRRRRGIFVAVRGVPQVPWPPPPTHGPGSPDKRPYVTLRDTIADLPAYPEHTDIGYDERGHQLLHFRRNPTAKSLDRYRAIPEGGNRFDLAKNRPDLLPDCWKNKPTGTTDVMGRLWWDKPSYTIRTEFYKPEKGRYLHPTADRPITHREAARLQSFPDHFIFEGSKIQVGRQIGNAVPPGLGKAIAEHVYNLAFDPERTDEVESDRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8S2</accession>
    <name>A0A1H6E8S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NgoMIV restriction enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94112">
        <property type="protein sequence ID" value="SEG94112"/>
        <property type="gene ID" value="SAMN04489712_14313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10010">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015105">
        <property type="entry name" value="NgoMIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037083">
        <property type="entry name" value="NgoMIV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09015">
        <property type="entry name" value="NgoMIV_restric"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="28154" checksum="F975BFEBE993A795" modified="2017-01-18" version="1">MTAAFAPELLGWRRPRGGKRPVPNCADSDSAQSVILAEGMLRELGLVPNDDRKVPTDPGPVLEEHVRRHLTEALPHLNSHRAWQVRRGTLITDFAQYAHLRRVDELVRDSAELRITIGQDYLIKPDVTVGIVDLAVLGSEPFLHGAVSCKWTIRSDRVQNIRHECNQMIRHRRGRQPHLVTVTAEPLPSRLASIARGTGEVDAVYHIAFDALDASVRVHGNSAQKDAWEECVEQRRLLSYKELPETLAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8S9</accession>
    <name>A0A1H6E8S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93671">
        <property type="protein sequence ID" value="SEG93671"/>
        <property type="gene ID" value="SAMN04489712_1409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="282"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG93671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="42099" checksum="FB3CB09AAA7519A3" modified="2017-01-18" version="1">MPDAVIVAMARSPIGRAFKGSLKDMRADDLLGQMLAAALAQVPALDPASIDDIMVGCAQPAGEQGYNIARQAAVGAGLDGVPGTVVQRYCASSVQTTRMALHAIKAGEGHAFVSAGVECVSRFGKGKADGMEDTHNPRYTEAEARTQARSTAGAPPWKDPREDGGLPDPYIAMGQTAENVARLRGVSRERQDEFGARSQNLAEKAIADGFFEVDITPVTLPDGTVVARDDCPRPGVTLEAVSALAPVFRPDGTVTAANCCPLNDGAAALVVMSGERARDLELTPLARIVSTGVSALSPEIMGLGPTEAMTRALAHAGMSVSDLDLVEINEAFAAQVLPVCDDLGLDLERVNVHGGAIALGHPFGMTGARLTTTLVNGLRRCDGQVGAVTMCAAGGQGMALILERMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E918</accession>
    <name>A0A1H6E918_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxo-5alpha-steroid 4-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_14034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93773">
        <property type="protein sequence ID" value="SEG93773"/>
        <property type="gene ID" value="SAMN04489712_14034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="22"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG93773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="484" mass="51291" checksum="6B83C6B0D93D4973" modified="2017-01-18" version="1">MNTTRTAPVPASQVRDWAAETDVIVVGFGCAGASASIEAARAGAEVLVVDAAGGWGGASAMSGGEIYLGGGTPVQKACGIQDTPEAMYDFLKLATGPGPHEDKLALYCEGSLEHFDWLVGCGVPFKSGLWTEPCWEAPTGYGLMYTGGENAHPFADLVPPAPRGHIVHMEDKRPGERSAGWMLMSHLVSTAERSGVMVRYGTRTERLVVDGDRVVGVGAVTFGERVFLRARRGVVLAAGGFGANPVMLAQHSPRLLGNWLVGTDHDDGGAIRMGQAVGAAVRHMEAAQAAFPADPALLFRSLLLDVHGRRFINEDTYPGRVGQAALFQQNRKVFILYDEAINEELQRTGGRAADPTWVSDDLAELERRMRIAPGVLAGTVEMYNANAEKGEDPLFHKSARWLRPITPPYGVLDLRDAAFGIFTLGGLHTSPQGEALDIDGAPVPGLFAAGRTTSGIPSWGYCSGTSLGDGTFFGRCAGRSAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EC59</accession>
    <name>A0A1H6EC59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan/xylan/chitin deacetylase, PgdA/CDA1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94526">
        <property type="protein sequence ID" value="SEG94526"/>
        <property type="gene ID" value="SAMN04489712_14814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296751" evidence="1">
        <location>
            <begin position="41"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="60"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="244" mass="26884" checksum="06A2FAA73BD37BDE" modified="2017-01-18" version="1">MSRHQTPYRRSRQRYLAVVAFAGGLSLSLGVLAPAEPAQAKIAGPAAVALPAAQQAAAEKVVYLSFDDGPSSGYTPKILNILAKRGVRATFFVLGENVNRYPSLTLRAHERGHSIQNHTWSHPDLRQVSWKTFTSQVGRTDRVIRAQTGYTPRCLRPPYGSVDSKVRSRAGSLGKTVKLWTVDPRDWSRPGSSVIARRVLDNVRPGSIILLHDGGGDRSQTVAALPTILRTLKARGYTFRRMWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S1V6</accession>
    <name>A0A1H5S1V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43888">
        <property type="protein sequence ID" value="SEF43888"/>
        <property type="gene ID" value="SAMN04489712_10123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046175">
        <property type="entry name" value="DUF6177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19674">
        <property type="entry name" value="DUF6177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF43888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="35524" checksum="23F9B24C9C5B1503" modified="2017-01-18" version="1">MMSGHPAVDIVTAKSTVVIQDRPLVPLSSWLTDVMARCAGTGQVLQVLTPHDARITLPLRLALGGPRARWVVQEPGDGYYDGFSGLPLIWDGAMFTPAVQERPEPSATFLRRPPGDLGHHLVVDLRVRHKATTDLELGGAAEALARALAGTAPRCWGTAEPALVRWSQSELTALCRRRSPRATWLAYMGPHEAGSAHPPFGGTIRVSRVTSGVKETVAFTVSYGPGREPPLEELAALADRYARAGVLQVLTAQWAPGGPDLTYPARWQGAPVPVALAVGPEGVAETGAAHAAASDGGRAIGDPGAPGMWYVLGDGTDTGAWNRLGDLMERLGGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S800</accession>
    <name>A0A1H5S800_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46746">
        <property type="protein sequence ID" value="SEF46746"/>
        <property type="gene ID" value="SAMN04489712_101111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF46746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15877" checksum="1DA2EFA5E14C5D66" modified="2017-01-18" version="1">MADRASSSITIRADRDEIMAVIADLPSYPEWAGGIRDVEVLETGPDGRPARARLTIDAGPIKDTYGLAYTWDPDGDGVHWELVEKGNVVSALHGSYRLAGAGQHTEVTYELAVDVRVPMIGLVKRKGEKMIIDSALKGLKRYVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SC52</accession>
    <name>A0A1H5SC52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase molybdopterin binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47391">
        <property type="protein sequence ID" value="SEF47391"/>
        <property type="gene ID" value="SAMN04489712_101130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="1">
        <location>
            <begin position="30"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF47391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="23793" checksum="E179E88545E8702B" modified="2017-01-18" version="1">MSSPSEQTPEAGALPPGQYVPRGWPVLHYGPVPRFRPKDWDFRVFGATASGEQHIWTWEEFEGLPRTEAVGDFHCVTKFTIPGNLWEGVSGTTIVELAPPHPDVTHVMVWAEYGYSANIRMADFLAEATMFALHRNGERLTPDHGFPVRLVVPHLYAWKSVKWARGVEYLIKDRRGFWEERGYHNVADPWREQRYSYQEDEGESPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SDA2</accession>
    <name>A0A1H5SDA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48596">
        <property type="protein sequence ID" value="SEF48596"/>
        <property type="gene ID" value="SAMN04489712_101164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF48596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="11612" checksum="AD93F276DD2EE3A7" modified="2017-01-18" version="1">MALPPLTPEQRAAALEKAAKARKERAEVKNRLKHGGTSLAEVLKDGQTDDVIGKMKVSALLESLPGVGKVRAKQIMERLGIAESRRVRGLGANQRASLEREFGGGANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SDH6</accession>
    <name>A0A1H5SDH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48038">
        <property type="protein sequence ID" value="SEF48038"/>
        <property type="gene ID" value="SAMN04489712_101148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF48038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="297" mass="31128" checksum="CEE0A0E4D52081B9" modified="2017-01-18" version="1">MSASMRNGPAAGDPEFRGIDPDALGHLLKQMNAANRAIIGWLDAHPPPAGVPATGHQRAQEVSVWVAEQLGMLNRRYNYAITHPDTGGGIRTGPAVPPRPAIPGTGGQGGGSGLGDGVAPPRSPRTTPKGAGDDLGTFPNRQDAQKAARADAFVINRALKEGRPIPDEVWRRLGQHADDPDYTEELYDRLGPAGIADLIRRAAGDEARLRAISESLGTASFHLPMNAAWLKALLAEADRDGTRDITVRVLLDADMSRRTDDALARLGLLPGGAAPQAPGGPARTPAPVQPGADRPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJ78</accession>
    <name>A0A1H5SJ78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49998">
        <property type="protein sequence ID" value="SEF49998"/>
        <property type="gene ID" value="SAMN04489712_101210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021530">
        <property type="entry name" value="DUF2877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11392">
        <property type="entry name" value="DUF2877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="330" mass="33735" checksum="78BCCAD5D19CD031" modified="2017-01-18" version="1">MTAVMREPVSLPTRQRPRPPLAGAARSAASVIPGAARTAGPDIPGAAGVSLRDLLDPPRTPGRVIAAFPAALYLEMRTAAEPRVLAVVCSDAVRLPNSVVIAAGSRDRPLRSIHEGEEAWAGDGLVEVGALRVRVRRWWDPSPTLGPVALARLTHGVRELEAALADARFGLAGHPDPHLLAGRCADGDLAGAVEAAERIVGLGPGLTPSGDDVLAALLVALRALGGSVQHGRTALWLADWLGAAVTADAETRTTTLAATLLHCAADGQASAEVIAVLRGIAGLEPLAPALRRLLAAGHTSGADLAFGLLAGCRAVLTLSLTALKGHRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TD27</accession>
    <name>A0A1H5TD27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60699">
        <property type="protein sequence ID" value="SEF60699"/>
        <property type="gene ID" value="SAMN04489712_101572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF60699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="199" mass="20870" checksum="2EF4DA4CD44E35C4" modified="2017-01-18" version="1">MVAVLTVTPGPDMLLVLRNGLRSGPQVAWFTGLGCCLGISCHAVAAVLGLSAVLAASATAYTVVKVAGAVYLAYLGVRMVLAAVRKDGGGPDVPVAAGVLRRGEAFRQGLLTNLLNPKIALLFLTLLPQFVGSGEPRLRTTALLALVFLAIAVAWWRLFTLALRPVSRLLRGERARRTLDGVAGVLLLGIGARVVLEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TDL9</accession>
    <name>A0A1H5TDL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60896">
        <property type="protein sequence ID" value="SEF60896"/>
        <property type="gene ID" value="SAMN04489712_101578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284949" evidence="3">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF60896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="18323" checksum="DEE6855CE2C7A6AE" modified="2017-01-18" version="1">MRHTLGLLCGVLLTPALIYGVSWSFAQAAGSFDPVAREITDETRLRGGVALMAAVGLVAGVVVVSRWASPLLSLVPALTLIGWSVYFFVAPDRALALPSELPPQGPLDATVDSGLRMLLGTGVFALLGFVLLVPAGAPRRWAGRHPGEDPGGHADYADYDEEPTSGRRQPEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5THM8</accession>
    <name>A0A1H5THM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SAMN04489712_101604</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61708">
        <property type="protein sequence ID" value="SEF61708"/>
        <property type="gene ID" value="SAMN04489712_101604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="15">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="140"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SEF61708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="390" mass="41505" checksum="58A3158B18554EDA" modified="2017-01-18" version="1">MSSDPRIIKDSFALLAPNADKAVAYFCGRLFAEHPGLRALFPPAMDAQREQLLRALTRIVWSLDAPDSLTEYLGALGRDHRKLGFRPEHYAAAGTALIATLRRFAGDGWSPRVEAAWTGAFSAAAATMVDAAEAAAAHAPPWWVGEVVGHERRVHDVAVLTVRPDQPLEFAAGQYVTVQTARWPRVWRRYSVANAPRPDGTLCLHVRAVPAGWVSGALVRHTKVGDTLMLGPALGAMTLDPDSGSDLLLVAGGTGLAPLKALLEQATTAAPGRRVHLVWGARTARDLYDLDELRSLEAARAGLRVTPVVAEDPGFDGMRGTVPEALERIDDPPGPDTDVYVCGPTAMVARTVRVLRDLGVPSERVRHDAAGLDAAAAALAPAVPVGVTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TKX2</accession>
    <name>A0A1H5TKX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63416">
        <property type="protein sequence ID" value="SEF63416"/>
        <property type="gene ID" value="SAMN04489712_101659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF63416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="17029" checksum="002BFEADB783B5E8" modified="2017-01-18" version="1">MKQMEVVGVRVEMPSNQPIVLLKETAGDRYLPIWIGAVEATAIAFAQQGVLPARPLTHDLFRDVLEALGVQLRTVNITALREGIFFADLVFSNGVEVSARPSDSIALALRTGATIFASEDVLEEAGVAIPDEQEDEVEKFREFLNTISPEDFGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TRQ0</accession>
    <name>A0A1H5TRQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64761">
        <property type="protein sequence ID" value="SEF64761"/>
        <property type="gene ID" value="SAMN04489712_101702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF64761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="378" mass="39519" checksum="7226824D2AEC7F6E" modified="2017-01-18" version="1">MSTPIKRVVVVGNGIAGLTAADSLRESGFDGELTIVGDEPHPAYSRPALSKALLLDGDDMSSHELPPPTHGANEIRGVRASGLDVERRLVSLEDGTALPYDRLVIATGSRARRLSDLPEELTLRGLDDALTLRGRLAASPSVVVVGGGPLGMEIASGCLAAGCRVTLVSQGTPLIVQLGPYLADVFVKAALDRGLTVVETGGARLEGQAGDARVVLEDGAVLQAGLVISAVGDVPNTDWLADTGMVEKGVLQVDSRGLVRPDIAAVGDPAAFPTPYGRRRIPLWSSAIEQAKVAAAALVRGDEAPPLRFQPYFWTEQFGLSLKAVGYLPVQGEPTYVEGGPGGSSLMRWSHDDGSGTAVALNHRIPIPRLRRLSQGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TZW6</accession>
    <name>A0A1H5TZW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67738">
        <property type="protein sequence ID" value="SEF67738"/>
        <property type="gene ID" value="SAMN04489712_101791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_C" evidence="1">
        <location>
            <begin position="258"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF67738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="382" mass="39941" checksum="4EF4C5C6B2F7A583" modified="2017-01-18" version="1">MSADVAIVGIGIHPFGRTPGVSGRRQAVVAARAALADAGVGFADLQFAFGGSHSAGDADTLVSELGLTSLPFINVANGCATGGSALISAYAAIMSGLHDLGIVIGFDKHERGAFNTDPAEHGIGAWYGETGLMLTTQFFGMKIQRYLHRTGMDAGVLTKIAAKAFRNGALNPKAWRRTPLSEAEIAASPMISHPLTQYMYCSPAEGAVALVLCRADRAHHYTDRPVFLRGATLRSRRYGSFEVFSPWLAIERADSPTVDAARAVFEQAGIGPDEVDVAQLQDTESGAELMHMAETGLCAHGEQDGLIAEGATEIGGRLPVNTDGGCIANGEPIGASGLRQVYENVLQLRGDAGAHQVPGGPRVGFTHVYGAPGISACTLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UYU7</accession>
    <name>A0A1H5UYU7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgB</name>
        <name evidence="12" type="ORF">SAMN04489712_10294</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80265">
        <property type="protein sequence ID" value="SEF80265"/>
        <property type="gene ID" value="SAMN04489712_10294"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="251"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF80265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="728" mass="82138" checksum="663AAD3AD9D680E9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V1P3</accession>
    <name>A0A1H5V1P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterioferritin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80608">
        <property type="protein sequence ID" value="SEF80608"/>
        <property type="gene ID" value="SAMN04489712_102106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014490">
        <property type="entry name" value="Dps-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018063">
        <property type="entry name" value="Ferrtn_UCP018063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018063-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF80608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="183" mass="20735" checksum="CAE32599074EACD0" modified="2017-01-18" version="1">MAEFLTDVKTLRERARQEIDKGPITVAYGADLPRVIQVCNEALATEIVCTLRYKRHYYTATGIHAESVAAEFLEHAQEEQQHADWLAERIVQLGGEPDYNPDTLATRAHAEYDQSTDLVEMIKEDLVAERVAIASYTEIAQWLGDGDPTTRRLFERILAQEEEHADDLRSLLERLPADLNRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V2D0</accession>
    <name>A0A1H5V2D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Osmoprotectant transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80878">
        <property type="protein sequence ID" value="SEF80878"/>
        <property type="gene ID" value="SAMN04489712_102116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF80878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="29559" checksum="43E9C467880812C9" modified="2017-01-18" version="1">MITFAGVTKRYPDGTVAVDRLDLQIPTGQITVLVGPSGCGKTTTLRMINRMVDPTEGTVAIDGRDVRDIDPPTLRRGIGYVIQQAGLFPHRTIVDNIATVPFLLGHDKRKARERARELMDRVGLDRSLADRYPAQLSGGQQQRVGVARALAADPPIMLMDEPFSAVDPIVRAGLQEEFLRLQAELEKTIVFVTHDIDEAVRLGHRIAVFAVGGTLAQYATPDELLSEPADDFVRDFLGGSRGIRRLRFFQELDAEEAGAGTDEATVAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V6C1</accession>
    <name>A0A1H5V6C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82925">
        <property type="protein sequence ID" value="SEF82925"/>
        <property type="gene ID" value="SAMN04489712_102188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF82925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="16732" checksum="8CCEE2BA0C399DF0" modified="2017-01-18" version="1">MPTILRLIRELADYEKALHEVRATEEDLRASLFGPEPRVFAHVAEQDGEVVGFALWFLTFSTWMGTHGIYLEDLYVRPEARGGGHGRALLTELARIAVERGYRRVEWSVLDWNEPAIGFYKALGATPQDEWTVYRLTGQALRDLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VPW6</accession>
    <name>A0A1H5VPW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease, Uma2 family (Restriction endonuclease fold)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88988">
        <property type="protein sequence ID" value="SEF88988"/>
        <property type="gene ID" value="SAMN04489712_102397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF88988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="20814" checksum="2FA59AF5EF043EA1" modified="2017-01-18" version="1">MTLQIDLPSDGVITRATFEGLPATPRGWAWELRDGRLELVHMPVTFWYWQVIMTVLQHWRRLGHEVAGEQYVADSGFARGRSGRNNFVADGVVFVAGHRPEPRETTHDASVIHLVVEAVSERSEENDAVDKFDVYAKLGIEHYWIVRGGADMGDSTEIDGMVAMHQLKDGAYEVVAHRMLSRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VQ27</accession>
    <name>A0A1H5VQ27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89412">
        <property type="protein sequence ID" value="SEF89412"/>
        <property type="gene ID" value="SAMN04489712_102413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF89412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="81" mass="9639" checksum="BCB54C17B45C719B" modified="2017-01-18" version="1">MIDERERRAAFRAWVRAHHPDVGGDPETFAAELRRRRAGGGRRDARERRYGPVVVVRRRPGLGLLERWLERRRRRGARDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VT29</accession>
    <name>A0A1H5VT29_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_102449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90442">
        <property type="protein sequence ID" value="SEF90442"/>
        <property type="gene ID" value="SAMN04489712_102449"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF90442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="175" mass="19193" checksum="09AAAE59300694EA" modified="2017-01-18" version="1">MNGSPPTVIVVTGVSGSGKSTVGRLLAEELGWEFADGDDFHPPANVDKMAEGVPLTDADREPWLRDVAAWIDARVESGAPAVVACSALKRSYRRRLIRRPGPVRLVYLDGDRELIERRMLSRVGHFFKSHLLGSQFRDLEPPGSDEHPVNVPIDGSPQDAVRHILTTLDLPRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VTV4</accession>
    <name>A0A1H5VTV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 9">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_102447</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 9"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90388">
        <property type="protein sequence ID" value="SEF90388"/>
        <property type="gene ID" value="SAMN04489712_102447"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="12">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="149"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEF90388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="457" mass="47783" checksum="E494D41024596630" modified="2017-01-18" version="1">MVHTPVRSLPLVDLGYSTALLTDQYELTMLQAALRSGTAGRRAAFEVFARRLPTGRRYGVVAGVGRLLEALGEFRFGERELRFLTSRGIVDEPTAAWLADYRFSGDIWGYPEGECYFPGSPIMVVEATFGEAVLLETLVLSVLNHDSAIASAASRMVNAAGGRPMIEMGSRRTHEAAAIAAARAAYLAGFANTSNLAAGLRYGVPTAGTSAHAFTLLHDSERHAFKAQLTALGKGTTLLVDTYDVERAVRTAVELAGPSLGAVRIDSGDLAAMARRVRALLDSLDAHDTRIVVTGDLDEYGIAALAAAPADAYGVGTSLVTGSGAPTASLVYKLVARADSEDPRAPMRPVAKRSVGKPSRGGRKSAVRRLDGHGVACAEVVSTGPPIDRASSGPRDRPLLVPLVKGGVVVGGEPLEAARERHAAAVRELPATALQLSAGDPAIPTEFVNGGPSAAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VUP7</accession>
    <name>A0A1H5VUP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91025">
        <property type="protein sequence ID" value="SEF91025"/>
        <property type="gene ID" value="SAMN04489712_102470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF91025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="25998" checksum="FA2C61661B66AE8B" modified="2017-01-18" version="1">MGEIRASTVLPAARTDITLHTADGLELVGELAVPVDRDPVATLVCLHPLPTHGGMMDSHVIRKASYRLPALAGLAVLRFNTRGTESERGVSQGSFGGGETEKYDVAAALEYAEYHDLPRPWLLGWSFGTELALKWGRDPLVQGLLLLSPPLHRATDADLDAWGADGRPVVALVPEHDDYLRPPEARERFKRIPQAEVVGVDGAKHLWVGEPYVRIVLNEVVKRVAPQAHPLPEEWPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VVF5</accession>
    <name>A0A1H5VVF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90841">
        <property type="protein sequence ID" value="SEF90841"/>
        <property type="gene ID" value="SAMN04489712_102463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="272"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF90841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="40604" checksum="0801E1BBC729D51C" modified="2017-01-18" version="1">MPANSVIVAGARTPIGRLLGSLKDFTAADLGGIAIKAALERAGITGDQVQYVILGQVLQAGAGQIPSRQAAVKAGIPMNVPSITINKVCLSGLDAIALADQLIRAGEFDIVVAGGMESMTNAPHLLPKSRQGFKYGSVEVLDHLAHDGLTDVFDDCSMGESTERFNAKLGLTRAEQDEFSARSHQRAAAAVKNGVFDEEIVPVPVPQRRGEPVMFTTDEGVRGDTTVETLGRLRPAFTKDGTITAGSSSQISDGACAVVVMSAAKAAELGLTPLAEIGAHGNVAGPDNSLQSQPSNAIKHALAKEGLAVDALDLIEINEAFASVAVQSMRDLGVDADKVNVNGGAIALGHPIGMSGARIVLHLAHELRRRGGGVGAAALCGGGGQGDALILRVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W470</accession>
    <name>A0A1H5W470_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-dependent flavin oxidoreductase YrpB, nitropropane dioxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94282">
        <property type="protein sequence ID" value="SEF94282"/>
        <property type="gene ID" value="SAMN04489712_102582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF94282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="369" mass="39705" checksum="4D26C9F2DBC589D8" modified="2017-01-18" version="1">MRTRVTELFGIEYPIFAFSHCRDVVAAVSRAGGMGVLGALHFTPEELELELKWIDEHVGGRPYGVDVVMPAQYEGADLGDAEELVARLQGMIPDRHRQFVENLLAEHGVEPSTEGADKILLGWTDATARPQVEVALRHPIALLANALGPPPADVVEEAHRHGVKVAGLASNARHARKQVAVGVDIIVAQGTEAGGHTGDVSTMVLIPEVVDAVGKDTMVLAAGGIGRGRQMAAGMALGADGVWTGSIWLTVDEADTPEVARGKLLDATSRDTVRSRSWTGKPARLLRTPWTEAWESEESPGTLPMPMQFMLIADALRRMHRSGDGELVTFPVGQIVGSMNQVKPAAQVVYDLIEEYVDAVERLNKLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W4N9</accession>
    <name>A0A1H5W4N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94343">
        <property type="protein sequence ID" value="SEF94343"/>
        <property type="gene ID" value="SAMN04489712_102584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="57"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF94343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="27214" checksum="F2B9068B8767B7DE" modified="2017-01-18" version="1">MGQPQAAYRATLGRSFRLLGAFRREQADPESFYGLMARDTVAQLAAYTGLDGATVIDVGAGSGFFTRELTRAGARCAGVDVDAGEITAYGPPRGDCVVGSALRLPFGTGTADVCFSSNVLEHVPDPWQMADEMVRVTRPGGVVYLSFTNWLSPWGGHETSPWHYLGGHRAARRYERRHGRPPKNRYGTSLHPVSIGDTLAWARRRADVRVLDALPRYHPSWAKGVVRIPGLREVVTWNLVLVLRKTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WCL2</accession>
    <name>A0A1H5WCL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose/mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97006">
        <property type="protein sequence ID" value="SEF97006"/>
        <property type="gene ID" value="SAMN04489712_102662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05637">
        <property type="entry name" value="SIS_PGI_PMI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="47"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF97006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="379" mass="39976" checksum="38A050F1421B2224" modified="2017-01-18" version="1">MSEVAESWRLDDPRALTAADPGDMLRQVASSAAQIRQARLAAEEAGLARLAEDGRPRAIVVTGMGGSGISGEVLAAVCGVGCPVPVLTVRGYRLPGWVGAADLVIAVSCSGTTEETLAVAAEAVRRGCRMLLVGGAGSPLADLAAQARAPFVPVHSAGMPRSTLWGLSIPLVLAARALGLANAPDEVLEATARRLEDLAHRCRPSSESFVNPAKRIALDLAGELPMVWGSSDLAATAAYRMCCQLNENAKYPGVYGGLPETDHNQVVTFDGFFAGAAPVDADDFFRDRVDDPEGTRLRLVVLRDTDEHPQVRKRREVSVELAQARGVAVTEITAEGEHPLERIASLIAMSDYVTVYLAIALGVDPTPVSAIQELKARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WYE4</accession>
    <name>A0A1H5WYE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04323">
        <property type="protein sequence ID" value="SEG04323"/>
        <property type="gene ID" value="SAMN04489712_1038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009288866" evidence="2">
        <location>
            <begin position="29"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG04323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="175" mass="19078" checksum="B3719C2DB0FE3470" modified="2017-01-18" version="1">MRRQRRAAIAVAAVPLLALGLAGCGSQGDGKNAADKAAASRAAEQERVRQFAKCMRENGVDMPDPEVGPDGGIKLRMRAESGQKGAGEEESRAAMNKCRKYMPNGGKPQKLSPQDQEKLRQFARCMREHGVKMDDPRPEGGIVISRKKGDGLSDEEFEAAQRACQKFQPRPKVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XBT4</accession>
    <name>A0A1H5XBT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09113">
        <property type="protein sequence ID" value="SEG09113"/>
        <property type="gene ID" value="SAMN04489712_103180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="PTHR37539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289242" description="MPAB_Lcp_cat domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="134"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG09113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="417" mass="45638" checksum="CBAFAA8F2B5862E3" modified="2017-01-18" version="1">MDKPSRRNVLMAGGTLGAVGALSAATPAHAGSLWTWSPTGSVAGTGEGADPRWVWDEEADQLVAALIDRGDVPRVNRLLRTWTKNGQPLPSGLPADLRDFMERARRLPSWADQGKLATAVNFNEKRGLYLGVTYGFASGMMSTAIPKEARAVYYSKGGADMRDRITKTAKLGYDIGTSNAYKPTGEMVVTCVKTRLAHAGVRHLLPKSPHWSKVADEEIPISQADMMVTWHSLPTTVMQNLAKWKVPIPAAESEAFLHSWQVCAHMLGIKDEYIPNSWAEANAQAKQVLDPILAPTPEGIKLADILLNMGTLVPGGPLRYITKPILGSLTRYILGDEIATWLKIPREPLWDGVFETLWEPFVAVREGLLSLEQAPGALQKFYWAFDEILRLGVLLVLSGADLPISIEIPDANNPNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XF54</accession>
    <name>A0A1H5XF54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09987">
        <property type="protein sequence ID" value="SEG09987"/>
        <property type="gene ID" value="SAMN04489712_103213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG09987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="121" mass="13784" checksum="795BB2678F325A6E" modified="2017-01-18" version="1">MTGGPELHGFPPPELLPDLRWLGPDYLSLLVSDLARGLLRQDPGTRLMGVRCEGAPELWTEVDAAGTPRARHVTFPLQVFLQDGAERPWMLRGRWSYVGRELDTREACIDHYWRLLTFEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XG32</accession>
    <name>A0A1H5XG32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, LacI/PurR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10728">
        <property type="protein sequence ID" value="SEG10728"/>
        <property type="gene ID" value="SAMN04489712_103239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG10728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="34129" checksum="79BBA342415A1755" modified="2017-01-18" version="1">MHAGVSEATVSRVLNGKPGVSAAKRQAVLGALDVLGYQRPARPAQRPQGLVGLITPELDNPIFPAFAQAIERSLAQHGHTTILCTQVPGGASEDEFVDQLVERGAQGIVFVSGLHSDVGASAERYARLLGKGIPIVMINGHKPETGAPALSTDDRLAARLAVSHLADLGHRQIGLAVGQRRYLPALRKVEGFRTAMADLLGLTSVEELIEHTLFSVEGGQAAAAALLDRGCTAVVCGSDLMALGAIRAARSRGLRVPADVSVTGYDDSPLVAFTDPPLTTVRQPVTAMAMAAVDTLLEAMHGGASRGIELVFRPELIVRGSTGAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XL67</accession>
    <name>A0A1H5XL67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12524">
        <property type="protein sequence ID" value="SEG12524"/>
        <property type="gene ID" value="SAMN04489712_103306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289591" evidence="2">
        <location>
            <begin position="37"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG12524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="20318" checksum="034C54413BE7692E" modified="2017-01-18" version="1">MNSKYRRPYAAVAAVAALTATVSGCGLTGPAMNAGADIAEFTVTSPAFHDGKDLPARFACPAYPGGQGRTPPLRWSGAPNQTTRAFAIVMDDPDGSDGAHVGWVIANIDGTTNELIEGARPEKAVEALNTSKKTAYVPPCPPKGERHRYRFTLYALSERVPLQQGAPLKEALSSIAKYTVGRGRITGNFGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XME5</accession>
    <name>A0A1H5XME5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12921">
        <property type="protein sequence ID" value="SEG12921"/>
        <property type="gene ID" value="SAMN04489712_103321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG12921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="30661" checksum="E6FDCF88C0304E4A" modified="2017-01-18" version="1">MGEAGIAGRLEADPDIRLTAYVFSRVYGDLPQGAWRAPGTLTLLGGPEAALTVALPWGAVVAAAPCADGSELYSLNHHEGPLAPSPGMRPPPWALPCVRALESVPAGAGLRVAVNRLLPDQMGLLSGAETFSAVSLALRDLRGLEPSGADPCSLHGPARALLLRAGSAAEPVPFDLEAAGLRLLLVELGPGGTGPASSEARAGDTVAVAERLRGGDCTALGAMLTQAHRPGNEAADLALEVALGVGALGGRRIGRCVLTLAPVPRIRDIRTAVTTRLEGLTVRPPRFLTAVPSDGAHRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YN81</accession>
    <name>A0A1H5YN81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25538">
        <property type="protein sequence ID" value="SEG25538"/>
        <property type="gene ID" value="SAMN04489712_10498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG25538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="247" mass="25296" checksum="E5071454F63CF338" modified="2017-01-18" version="1">MNGRRILVTGAAGGIGTSLVAELLLQGARVLATDVDESGCRLLERRIGGRPEDGRLHTMPLDLTESGAPQRIVDRAIDRLGGLDGLVNNAGVEHRAALAEHGTADWTRVLEINLSAPFRLARAAAPALAGQPGAAIVNVCSIAVTGFAGQAAYDASKGGLLSLTRSLAVELGPLGVRANAVCPGFIDTPMLDASGLRGLAEKVAARLPLGRCGHPEEVAAAIVWLLGTSAGYVTGQALFVDGGMVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YV78</accession>
    <name>A0A1H5YV78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28153">
        <property type="protein sequence ID" value="SEG28153"/>
        <property type="gene ID" value="SAMN04489712_104210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG28153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="27323" checksum="BD69789E9CC3AD46" modified="2017-01-18" version="1">MTSTFTPVPPGSGAGAPPAPPAVVATEVAKVYGSGDAAVHALRGVSVSFAKGAFTAIMGPSGSGKSTLMHCLAGLDTVTSGRVTLGEVEITGLGDRRLTLLRRERVGFVFQAFNLVPTLTAEQNILLPLELAGKKPDRDWFDQVVEVVGLRDRLSHRPAELSGGQQQRVACARALVSRPEVIFADEPTGNLDSRSGAEVLGFLRSSVREMGRTIVMVTHDPVAASYADRVVFLRDGRIVSELARPTPDAVLDQLKALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YWE7</accession>
    <name>A0A1H5YWE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28102">
        <property type="protein sequence ID" value="SEG28102"/>
        <property type="gene ID" value="SAMN04489712_104208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="300"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG28102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="398" mass="42871" checksum="95911E12685DBDC1" modified="2017-01-18" version="1">MVRRAWAWWRAHKALVDLVFVAPLLLVSVLSVSAYTAPPHGAPAGPIPEPVYAALVAGLLLPLVVRRRWPVQVFLWIAAVSFGQWLFDVTVILANMGVLIAMYTVAANCSFRWMVTAGLIGELGAVLAALRYTVEPGARKYTVVMLSAVVAGVWILGVYISTRRAYLRSLEERAARLERERDTQVQIAMAAERARIARELHDVVAHNVSVIVVQADGASFAIETDTERARRALEAISATGRLALAEMRRLLGVLREGDDAGSYAPQPGVAQLTDLVEQIRGSGLPLDFRVEGVPVELPPGMQLTIFRIVQESLTNTLKHGGPGASARVRLHYGDEAIEVTVADDGRGAAARDDGLGHGLAGMRERAAVYGGSVRAGPRAGGGFEVVARLPLREEARST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YWH6</accession>
    <name>A0A1H5YWH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28374">
        <property type="protein sequence ID" value="SEG28374"/>
        <property type="gene ID" value="SAMN04489712_104219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG28374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="76" mass="8611" checksum="9F073027D0132266" modified="2017-01-18" version="1">MEQATLARRGTDEPRLSEDDIRLLAQIASGVTADVAARRLELSARTLRRRLRTICDRLDVNTPIEAVVWAARRQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z768</accession>
    <name>A0A1H5Z768_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31447">
        <property type="protein sequence ID" value="SEG31447"/>
        <property type="gene ID" value="SAMN04489712_104358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG31447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="21826" checksum="C5C06BDFAC2C5170" modified="2017-01-18" version="1">MFGRRDELAQVEARLAELEERLAERVDAVSGDAARIERKLDDLEARLRGEPVDRVEFLLASVAEEVRADLKGLVADAERLRQVTRDVEHRHEEAERALRALVSRLEGGIEPPARSKVVFNKVYRAETLLYVAAYFTYGKPTEVSILAGDEDPPTTVCSGMGSDYASAIIRPGEYWMVKSKRERSDVKCLCTPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z8Q9</accession>
    <name>A0A1H5Z8Q9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="7" type="ORF">SAMN04489712_104410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32454">
        <property type="protein sequence ID" value="SEG32454"/>
        <property type="gene ID" value="SAMN04489712_104410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG32454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="93" mass="10713" checksum="035BF1443FA83E1C" modified="2017-01-18" version="1">MPRSLKKGPFVDDHLLKKVETQNEKGTKNVIKTWSRRSMIIPEMIGHTIAVHDGRKHVPVFVTDAMVGHKLGEFAPTRTFRSHVKEDRRSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZE11</accession>
    <name>A0A1H5ZE11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03083 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34688">
        <property type="protein sequence ID" value="SEG34688"/>
        <property type="gene ID" value="SAMN04489712_104511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="25584" checksum="29D949C9C42B7DF8" modified="2017-01-18" version="1">MTCVNHERILATFRAEAERLAGVVGALSEREWDRPTACEPWRVRELLGHVRVVIGWLPDMLDGPAPARAQVSAREYYRPDERFSAETNAARIALAVEYAAAQDSGVALAEDFTDTWENAYRLCRAEPPGRVIVTRHGDAMLLSDFLLTRVVEVAVHGLDLAAALEREPWLTSQAGDAVEELLLEAEDVARVRGIGWDQVTFLRKATGREPISPDEAEWVRGLGVRWLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZGN5</accession>
    <name>A0A1H5ZGN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35421">
        <property type="protein sequence ID" value="SEG35421"/>
        <property type="gene ID" value="SAMN04489712_104545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG35421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="28540" checksum="F9A8105413F1B272" modified="2017-01-18" version="1">MHAKTQVREVDSVGDAPDIIWLRPERPARGPRPAYSRAQIVEAAIRVADHEGLDAASMRRVAKEIGAGTMSLYRYIPRREDLIELMVDAALGELDLPERPSGDWRADLTLLAHGLRAVSLRHPWLTRLPQTRRVFGPNALRMLEFGGGTLDGRGLSIDEMMTLFGIFNGYVDGFVRAEVSWAEEERRTGMDRDQWMAYTSPYVHQILAGGRHPVFSKVVIEARQPHMDPEARFEYGLGLILDTIAASIPAPSGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZU92</accession>
    <name>A0A1H5ZU92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40103">
        <property type="protein sequence ID" value="SEG40103"/>
        <property type="gene ID" value="SAMN04489712_10515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG40103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="375" mass="39694" checksum="2A49CB4CDE39F3AE" modified="2017-01-18" version="1">MRPLTLPQAAAAVVVAARLARGRDRLAPLAPPPPDAVPQPISVVIPARDEESRLGACLAAVLTDPAVREVIVVDDESRDGTARLAARLGATVVPGAPLPDGWVGKQWALRQGVSAAAGPVIVTLDADARPRPGLFGALAALLDAYDLVTVGPRFACAGVAEQALHASFLATLVYRFGPVGPARPPPPHRLLANGQCTAFRKAAMAEADGFGRVRRHLTDDVALVRVLARDGWRIGFLDAGSLLEVDMHESAAQVWREWGRSLALRDVTTRSRLAGDLAVIWLTAALPLLRLAAGRPTRLDLALLGQRLLLMAALRGAYVRPGPGLALSPLFDVAAAVRLTQAALWPARTWRGRTYGPEAVSHADRPAPPDRSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZVP6</accession>
    <name>A0A1H5ZVP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenazine biosynthesis protein PhzF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40222">
        <property type="protein sequence ID" value="SEG40222"/>
        <property type="gene ID" value="SAMN04489712_10522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG40222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="294" mass="30641" checksum="C3579610027AB489" modified="2017-01-18" version="1">MTNPPSASGVQIVRYTAFTTDPAGGNRAGVVLDAAGLDDAAMLGIAADLGYSETAFLTAPPDGLGEEGRAFTVRYFSPKAEVPFCGHATIATAVALAERIGPGPLVFATRSGTVPVEVAEDPQGALRATLTSVEPYVEEAGEADVSEALAALGWRAEELDPALPPRIAYAGARHLVLAAATRARLADLDYDFERLTAYMTARDLVTVQLVWRESADTFHVRDPFPVGGVVEDPATGAAAAAFGAYLRELGQVGPAAELTLHQGEDMGRPSVLTVELREGDPRVRVSGTAVPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZX73</accession>
    <name>A0A1H5ZX73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40066">
        <property type="protein sequence ID" value="SEG40066"/>
        <property type="gene ID" value="SAMN04489712_10513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007354">
        <property type="entry name" value="CruF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39419">
        <property type="entry name" value="PTHR39419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04240">
        <property type="entry name" value="Caroten_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG40066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="26428" checksum="6ECF01119EFC1A46" modified="2017-01-18" version="1">MTAWGGCGTARRERPRAFTVAGAGCLAAMVAAQVLSGLQPRPVRLTSVVVVLLAASALAFAAGRHGPRRAVGALAATVAAGYAAEWIGVRTGVPFGRYSYTPVLQPQVGGVPLIVALAWGGMGLAAHAVATAIVPGGGLARIATGAAALTAWDLFLDPQMLRLGLWTWADPGPYRGVPISNLLGWLLVSALVMALIDARLGRTDAVAAGLAVLYAVMAAMETLAFAAVFDPPDRLVAAAGGIAMGTFLVLAGRRRWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A3G6</accession>
    <name>A0A1H6A3G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl-peptidase-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42981">
        <property type="protein sequence ID" value="SEG42981"/>
        <property type="gene ID" value="SAMN04489712_105171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="2">
        <location>
            <begin position="109"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="490"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG42981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="690" mass="74785" checksum="E1B1FD4C8A4EDA51" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A493</accession>
    <name>A0A1H6A493_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42895">
        <property type="protein sequence ID" value="SEG42895"/>
        <property type="gene ID" value="SAMN04489712_105166"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG42895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="42761" checksum="10D88F637B07341A" modified="2017-01-18" version="1">MTRTQQLRALSEEHSAHNYHPLPVVIAEAEGAWVTDVEGRRYLDMLSAYSAVNFGHRNPRLIAAAQRQLERVTLVSRAFDHDQFGPFVAELAELAGKDMVLPMNSGAEAVETALKAARKWGYEVKGVPADQAGIITFEGNFHGRTTTIVGFSTDPDARNSYGPYTPGFRTVPYGDAEALRAAMDENTVGVLIEPIQGEAGVNVPPSGFLKTVRELCTAGNALMIADEIQSGLGRTGATFAVEHEGVVPDMYLLGKALGGGILPVSAVVADADVLGVFRPGQHGSTFGGNPLACAVGREVVAMLRTGEFQERSRTLGAHLHRRLGALPGDVVREVRGRGLWAGVELNGKARPVSERLMELGVLAKETHETTLRLAPPLMIDQEDLDWALDQLEIALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A6C2</accession>
    <name>A0A1H6A6C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44279">
        <property type="protein sequence ID" value="SEG44279"/>
        <property type="gene ID" value="SAMN04489712_105243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="21590" checksum="F16A4EACCD679A75" modified="2017-01-18" version="1">MTTILILLAVWTAVALLIAPPIGRMLRRAADAEILAPLDSEDDGPTLAMTAVGDCPDWCPGQHTPGAHRRTVDVREKTGDPGGVWVELAWYTVPGRPPVGQPEVTLVSIVGTDETLMPMSPGEAGMLAASIAFPDADSTLAAWGRALSGDAGWLAETLARAAVMAGYSPCGGCGTPTDARPEYDQASGELVARCAGCHREALTGGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A8Y8</accession>
    <name>A0A1H6A8Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage major capsid protein, HK97 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44832">
        <property type="protein sequence ID" value="SEG44832"/>
        <property type="gene ID" value="SAMN04489712_105273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024455">
        <property type="entry name" value="Phage_capsid"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01554">
        <property type="entry name" value="major_cap_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG44832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="467" mass="50783" checksum="65DCAE7940BCF3BC" modified="2017-01-18" version="1">MTLDDLINQARQALQEALAARQREQDALMALREDPNLTEDAVSERVAARDAADAEVTRRQEALDGLLAEQAREEEIAALQARITPTDVRRPAYDQVARVGAEERTYRPDTDPRGARFQRDVIAAVRGDYEAQGRLARHMQEERVERAAALTGGEERAVGTGAFGGLVIPQYLVDLYAPLARTARPFADACRQHPLPAQGMTVELARVTTGTNVDNQANQHDAVAETDIDDTTLSIPVRTAAGQQTVSRQALERGAGVEEVILDDLFRAYATRIDTTMINVATVGLSAVATAVTYTDASPTTAELYPKVIEGLAGVEASLLDQASGDNLAVMHSRRWYWMQNAMGSSYPLITQPGVVPQTLGANYAEVYGRGVRGILPNGTPVIVDNNIATNLGAGTNEDEVYLVDRRECHLWEDPSAPMYIRAEQTKAATLGVLMVVYGYYAFTFQRQPHARKISGTGLVTPTFTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AAA3</accession>
    <name>A0A1H6AAA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45124">
        <property type="protein sequence ID" value="SEG45124"/>
        <property type="gene ID" value="SAMN04489712_105287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG45124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="213" mass="22628" checksum="BB6D002F0A6B8AB5" modified="2017-01-18" version="1">MGSGWRDWQPGDTVTEPFIQGYLQDQTVMVFASGTARDAAITSPQRGMCVYLLDTKRFSIYESSAPAGWISSIQIGEWSTYTPQLLGSIQNFGAGNGSATGRWARWGSLVTFYAEIVYGSTSTSALGNLSMTLPATGPRTGNEQWVDCSLKDASAGRIFPGQAGPLAAASVPLYTQSGTGGSLERMTDISPAGQVVTNTGDAIRMWGQYEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADX6</accession>
    <name>A0A1H6ADX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46943">
        <property type="protein sequence ID" value="SEG46943"/>
        <property type="gene ID" value="SAMN04489712_105392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG46943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="29964" checksum="79A925B68BEA372F" modified="2017-01-18" version="1">MVTARTHDSVDVLGVRVSVVDVPLLRRRLCEAIERRDQLTITFANPNYVMAARKDPTLRELMNSFDLNLADGWGVVMAARIFGKPVPSRMANDDLTDEFFGLSAERGWRVFLFGNAPGVAQAAAENLRRWYPGVQIVGTQHGHWADASGRIPDETADRLVREINEARPDILHVGLGTPLQQIFVNEHLGRLTAPVIVTCGAYFEHLAERREYYPAWILRLRLGWLYRLFRDPRAMWRRYTIELGSYVLRVLAYRIRHGKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZS1</accession>
    <name>A0A1H6AZS1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_106100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53555">
        <property type="protein sequence ID" value="SEG53555"/>
        <property type="gene ID" value="SAMN04489712_106100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="403"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG53555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="447" mass="48400" checksum="EC4C4AB3FB331D25" modified="2017-01-18" version="1">MNLPADFLFGAATSAYQIEGAVTADGRLPSIWDDFCKVPGAVAGGDTGDVTCDHYHRWREDIALMRRLGLDAYRFSVAWPRVVPRGAGQVNGPGLDFYDRLVDALLEAGIRPFVTLYHWDLPSALQEQGGWPSRDTAGHFADYAAVVAARLGDRVTDWTTINEPLCTAWIGHLEGRFAPGLRDLHQAVHASHHLLLAHGLGAAAVRAHAASPPSIGLVNNLSPIVAASDRAEDVQAATRADGHINRWWLDPTHGRGYPADMIEVYGVEPPVRESDLETIAAPVEYTGLNYYFRQVIADDPDGPAPYARQVPVPGAQTTAMGWEVHADGLADLLLRLGGEYAATRIYVTESGSAWDDKVGADGSIDDQDRIAYLEDHLAAVARAAAAGAPVKGYFAWSLLDNFEWADGLDKRFGLVHVDRATQDRTVKASGHRYAEIIRAHHTPGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B504</accession>
    <name>A0A1H6B504_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55931">
        <property type="protein sequence ID" value="SEG55931"/>
        <property type="gene ID" value="SAMN04489712_106271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG55931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="214" mass="23372" checksum="95238975997EA25D" modified="2017-01-18" version="1">MIRVLIADDQRMVRAGFRMIIDAQPGMRVVAEAADGAEAVELARRLRPDVSLLDIRMPRLDGLAATRLLAGPQVPDPLRVVIVTTFDLDEYVYGALRGGAVGFLLKDGGPALLVEAVRAAVKGDTLVSPSVTVRLLEHLTRPRPPARRPHEPLTGRELEVVRLVARGRTNDEIAGELYVSLSTVKTHLGSVQRKLAARNRVEVAAWAWESGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5X8</accession>
    <name>A0A1H6B5X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56251">
        <property type="protein sequence ID" value="SEG56251"/>
        <property type="gene ID" value="SAMN04489712_106298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="31550" checksum="1BCEB93BFF7D4680" modified="2017-01-18" version="1">MAAITAPRRGMRRLFPCIMPLEATRGSSFHLAVLCRQNGGVRHGIVFTFPSGVAWRDGPGRACALGPVPVRPPGSAGRSVRRGRRPPGGEPSSRVPSTTGLIRLFSVRGVAGLSRALEAIDGRVPAPAHDMSGRTSPGRYRRDAGRFRPSHQAGRRACPHRWRRARSPTGESSRQPNARRVGRRGGGGEPHRLAWCRSRRKPGNEAAGCGGRHGHAEPGHHHRTRSAYSQGDRNIRCTLTLPLPTANAVGYWRPARRQLIPITICCGSCSPAYAAAVRVRPDRTHRCSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BML3</accession>
    <name>A0A1H6BML3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimO</name>
        <name evidence="11" type="ORF">SAMN04489712_107214</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61446">
        <property type="protein sequence ID" value="SEG61446"/>
        <property type="gene ID" value="SAMN04489712_107214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="172"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="405"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG61446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="486" mass="51178" checksum="B089A5EFD6EC3A13" modified="2017-01-18" version="1">MSARRTVSLVTLGCARNEVDSEELAARLEGAGWDLVDDADQAGVVVVNTCGFIDAAKKDSIDTLLAAHDSGAKVVAAGCLAERYGAELASSLPEADAVLGFDDYADIGDRLDDVLAGVRRPAHTPRDRRALLPITPVERKESARQVAIPGHGEELPEGVAPASGPRVLRRRLGGGPVAPLKLASGCDRRCTFCAIPAFRGAYVSRDPAEVLAEAGWLAGHGVRELVLVSENSTSYGKDLGDLRALEGLLPRLAAVEGVGRVRLSYLQPAELRPGLIDVLCGTPGVAPYFDLSFQHASGPVLRRMRRFGDREAFLELLARIRDKAPEAGVRSNFIVGFPGESEDDLAELVAFLSEARLDAIGVFGYSNEEGTEAATLDGKLDDDEVARRVAEVSALAEELTAQRAEERIGSAVEVLLEEQVEPGVFEGRAAHQAPEVDGTVLVRGEGLVVGEFVTATVVDGDGVDLVADVVADVGVGLAADVPADAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BMW2</accession>
    <name>A0A1H6BMW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61785">
        <property type="protein sequence ID" value="SEG61785"/>
        <property type="gene ID" value="SAMN04489712_107244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG61785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="30603" checksum="E4A49755D2B349EE" modified="2017-01-18" version="1">MSRARSSWPSSRKWASSYGRRPPRSRRRSFEGLPKLSPILLRAPARAAAAGRRLPAGGPSRRPPGRPWAPTAAPAPRCPGRAPRLSRARGPVPRVPGPRVLVPRVPGPAVAARAVRRRVRVPFRRPPCSRCRVRRAPRAAAVPGRRRPPRRRAPRLRPCPAVPPPVRAATAAMAVPRCPSRVLARPSRAPVPARARVADVRAPRVRATTRSARPTPAWGPRPSPVRVPARPPVSARATAARAAATGPVVRVRPRRVPVLGPAVRVPAVAAVCRRVRAVRGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUD1</accession>
    <name>A0A1H6BUD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein, DUF1015 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64242">
        <property type="protein sequence ID" value="SEG64242"/>
        <property type="gene ID" value="SAMN04489712_1086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG64242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="452" mass="48410" checksum="E9A23E67F8FB93D9" modified="2017-01-18" version="1">MPTVDADLPFGTTPEEFSARIFGSREPWPDAGDAGAAGLELIPFRGVRFAPEVVGDLGAVTTPPYDLIDEDEVRRLMASDGHNAVRLILPPGDGDDGYRRAAATLRRWLADGALVADDEPALYLYEAAAEDGTRQRGLIGAVGLRPESARVILPHENVFPGPVRDRLSLMTATGANLEPIFLVYEGAGAAGPVDEIADGTPPLVEFRAGDGTSHRLWRVTDPAQHARIAAGLRGRRALIADGHHRYATYRALQARHRAAGDGAGPWDYGLALLVDSTRYPPHLGAIHRVLPGLAPETAVERARAAFRVIGPFDGLGEAVEALAREKGPAFLVGGGERLHLLTEPGEEWLARVMPAEHSERWRRLDTAVLDRLLVERLWGIAADEHTVEVVHDDPGAAVARARRAGGTAVVMNPLAVADVLAVAEGGERVPRKSTSFGPKPRTGLVLRLLDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUM4</accession>
    <name>A0A1H6BUM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64404">
        <property type="protein sequence ID" value="SEG64404"/>
        <property type="gene ID" value="SAMN04489712_10821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="13247" checksum="442D02AA5E83C012" modified="2017-01-18" version="1">MVPPRVARHPRRSYKRVMTTPRLPRDDIAAAMAARHELGPDYDDAFVDTVVARLQESLQTRPPVATARARRTGGDRTVLLTVSSLLAAIPLTGIAAGTTGLPGLIVAWVGLVLINVAHALRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C147</accession>
    <name>A0A1H6C147_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Prokaryotic ubiquitin-like protein Pup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Bacterial ubiquitin-like modifier</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pup</name>
        <name evidence="7" type="ORF">SAMN04489712_108215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic ubiquitin-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66694">
        <property type="protein sequence ID" value="SEG66694"/>
        <property type="gene ID" value="SAMN04489712_108215"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02106">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008515">
        <property type="entry name" value="Ubiquitin-like_Pup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05639">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03687">
        <property type="entry name" value="pupylate_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="ARC ATPase binding" evidence="5">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="modified residue" description="Deamidated glutamine" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG66694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="69" mass="7725" checksum="125146E8E0AEC337" modified="2017-01-18" version="1">MATKDTGGQKQTTRRDEEVEETQAAVGEDVAERHEKLSDDVDAILDEIDEVLEENAEDFVRSYVQKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8L5</accession>
    <name>A0A1H6C8L5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69320">
        <property type="protein sequence ID" value="SEG69320"/>
        <property type="gene ID" value="SAMN04489712_10972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="7">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="167"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG69320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="28767" checksum="5E10122799212191" modified="2017-01-18" version="1">MTDELPPGPAAVLAGVLDRPGDAPGQGEPLPPLWHWLYFLEWPAQSELGADGHPAHGHFLPPIPERTRMFAGGRLRVHAPLEVGRPAVRTSTLAGVNVKQGRTGEMLFVTVRHEIRQTGELRITDEQDLVYRSGSAPARHELDTRPLPSSQDPWRLPVAADTPLLFRFSALTANAHRIHYDAPYARDVEGYPGLVVHGPLLAVLMAELPRRHAPERRVTGLTYRFRRPVFLGEQALVTGGPDGRLAVVGPSGESRAEATAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8Q9</accession>
    <name>A0A1H6C8Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YcxB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69369">
        <property type="protein sequence ID" value="SEG69369"/>
        <property type="gene ID" value="SAMN04489712_10977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14317">
        <property type="entry name" value="YcxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="2">
        <location>
            <begin position="100"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG69369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="169" mass="18739" checksum="3475E3568C08C8B7" modified="2017-01-18" version="1">MVAFLDEGGMVDFTIEYELTPDEVGRALHRGLKLQLRAVRLAVPTILAVSGITCLLVDAIGLGVGMLAGAVLFPFVLAWSARRLAKRQLTYLCVPTTLRFTDDGYEYRTDQSATTMRWPLFGRVVSTPEFWLLFVGKQCSAFLPRRAFTSEQQAELDGFFAARQKAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCN0</accession>
    <name>A0A1H6CCN0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_109195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70714">
        <property type="protein sequence ID" value="SEG70714"/>
        <property type="gene ID" value="SAMN04489712_109195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
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        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="8">
        <location>
            <begin position="16"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG70714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="531" mass="58786" checksum="CE17590F24DD5A6A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEZ9</accession>
    <name>A0A1H6CEZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acsA</name>
        <name evidence="9" type="ORF">SAMN04489712_109282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="SAMN04489712_109282"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
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    </dbReference>
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        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
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        <property type="entry name" value="ACAS_N"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
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        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <end position="83"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
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            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
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        <location>
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            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <begin position="411"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG71534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="653" mass="71886" checksum="E63435FF6F27E4E5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJI4</accession>
    <name>A0A1H6CJI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73090">
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        <property type="gene ID" value="SAMN04489712_11070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="27622" checksum="6C5BC8DB2BEB5E6D" modified="2017-01-18" version="1">MSATESPAVLPHDIHGSGPHRVIALHGWFGDRTSFRGLHPYLDADAFTYAFPDYRGYGDARDLTGDYTLAEIAGDVIALADKLGWDTFSLVGHSMGGTAMQRVMLDAPGRVRKLVGISPVPASGVPFDEDGWALFSGAADEPGNRRAIIDFTTGSRLPARWLDEMVAGSLGNSAVPAFRAYLDAWARTDFHAEVVGNTTPALVIAGGLDPALSPDVMRATWLEWYPNAELVVLADAGHYAPAEAPLALISQMERFLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJQ1</accession>
    <name>A0A1H6CJQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72997">
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        <property type="gene ID" value="SAMN04489712_11059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="300"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG72997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="41151" checksum="AEF7B8409591B6E2" modified="2017-01-18" version="1">MRLVPARLRPRDTLRVGAAGLRTRPARVVLSALGIAIGIATMVAVPGISESNRADLLRRLDRLGTDLLTASAGTTLTGGRSPLPERAVQVTRGIDGVLTVGATGETTASILRTDKIPEEETGGIGVSATTPELLRTLKVDVVRGEWLNPATSHYPAVVLGPVAADRLGITEPGVPVWINDRWFTVVGVLGPAPLAPDIERSALVGWDAARTYLGFDGYPTTVYERSTPESVRDVQAVLARTINPENPEEVEVSRPSDALAARAAADEAFAGTLLGLGAVALLVGGVGVANTMVISVLERRREIGLRRSLGATRGHVRVQFLTESLLLSALGGTAGTVLGALITSGYALTRDLPIALRWWVFAGALAATLLVGAVAGLYPAARAARVSPTVALSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM34</accession>
    <name>A0A1H6CM34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74109">
        <property type="protein sequence ID" value="SEG74109"/>
        <property type="gene ID" value="SAMN04489712_110190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="12833" checksum="8BEAA813DEB68A72" modified="2017-01-18" version="1">MSSEEFDKAVETKVPDKYRPVMDALRELMREGAPQAAETTLYGSPAWKGNKALAIVSVSKTHLTFAFERGAEFDDPHGLLEGVGKKTRHVKLKTLDGLNRDALRDYIAQAVTLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRN5</accession>
    <name>A0A1H6CRN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane associated serine protease, rhomboid family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75672">
        <property type="protein sequence ID" value="SEG75672"/>
        <property type="gene ID" value="SAMN04489712_11170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="120"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG75672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="32390" checksum="A08BE7CF4638F116" modified="2017-01-18" version="1">MNAQAPGAPTEAPTCYRHPDRETYVRCTRCDRYICPDCMRDAAVGHQCVECVREGNRTVRQPRTVFGGQVSATPVITYTLIALNVLAYVAQISRPRLVGEFMMVGVFTDRFGFVHPGGVADGEWYRLITAAFLHSPPDGGSFGITHILFNMWALWVIGPQLERVLGHWRFITLYLLSALGGSVLLYLVDPAGAAVGASGAIFGLFGAFFVIAKRMNAPAGGIVFLLVLNLVITFTVPGISWEGHVGGLLVGGALAAAYAYVPAAREQDGRRTVLHAAAGAAMLVLLVALVVVKTSQLAGMTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSG8</accession>
    <name>A0A1H6CSG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75798">
        <property type="protein sequence ID" value="SEG75798"/>
        <property type="gene ID" value="SAMN04489712_11185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="100" mass="10963" checksum="088112AD07961B13" modified="2017-01-18" version="1">MAGNDSRSRPPRDFVIDGAWPHATLTDHHGAHVAQRLARRLAQAMAEQGLSANRLAHDSGVNRQTIANVLAGAVWPDLLTIAKLERALACHLWPAHQHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTV9</accession>
    <name>A0A1H6CTV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenite transporter, ACR3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75836">
        <property type="protein sequence ID" value="SEG75836"/>
        <property type="gene ID" value="SAMN04489712_11189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG75836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="39689" checksum="F00A6675777D58E5" modified="2017-01-18" version="1">MARTRATPTDPAAPVLARMSTLDRFLPVWIILAMVAGLALGRFVPDVRDWLEAVKIDGTSLPIAAGLLAMMYPVLAKVRYEEIGHLARDRRMMWLSLVLNWVVGPALMFALAWAFLPDEPAYRTGLIVVGLARCIAMVLIWNDLARGDREAAALLVAVNSIFQIAAYALLGTFYLKILPGWLGWQTQDVDFSMWGITKAVLIFLGIPLAAGYLTRRIGIRRVGAERYEQRFLPRIGPIALYGLLFTIVVMFALQGETITGEPLTVARIALPLLAYFALMWTISFWASRRAGLGYDRTATVAFTAAGNNFELAIAVAIGMWGVTSGQALAGVVGPLIEVPVLVALVYVALWLRRRMLAAPTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV92</accession>
    <name>A0A1H6CV92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2'-5' RNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76884">
        <property type="protein sequence ID" value="SEG76884"/>
        <property type="gene ID" value="SAMN04489712_111220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG76884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="23050" checksum="010D6FB65CA34425" modified="2017-01-18" version="1">MQRMRDHWWWRPGARPGRRMLLWHLLVDDQPDVRALAGRFRERLAGVGGLDPVPDEWLHLTTQIVGFADEIPRDEVKAMTSAVAESFRTLPPVTARIGRLYFYEEGVALGVEPERALDPVRDAIRRGVAQTVTAHQLDDQPDWTPHLSVAYCNTDGPAEPIFEALADPPEPCRLTVRWAYLVEQVRDGHLYRWDTVAAVPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYV0</accession>
    <name>A0A1H6CYV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholesterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78212">
        <property type="protein sequence ID" value="SEG78212"/>
        <property type="gene ID" value="SAMN04489712_11247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_oxred_C" evidence="1">
        <location>
            <begin position="469"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="540" mass="57871" checksum="EB3FE34FBB00618B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZY5</accession>
    <name>A0A1H6CZY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78592">
        <property type="protein sequence ID" value="SEG78592"/>
        <property type="gene ID" value="SAMN04489712_11297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="46" mass="4774" checksum="0366C11B30DEF418" modified="2017-01-18" version="1">MGIPLRLAAPAPAKVLNVTGLDHSLMICVTLAEALAFPFHRSVCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0D0</accession>
    <name>A0A1H6D0D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78036">
        <property type="protein sequence ID" value="SEG78036"/>
        <property type="gene ID" value="SAMN04489712_11217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="69" mass="7911" checksum="9C6F08A3C9DBFD60" modified="2017-01-18" version="1">MPNAEMSPVSIAFWSSVRRCRIRMASWRGISSMSRWAWGVKRVVTVREQPLQGLCSLPQIHQAMAYTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0F2</accession>
    <name>A0A1H6D0F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78617">
        <property type="protein sequence ID" value="SEG78617"/>
        <property type="gene ID" value="SAMN04489712_112101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="75" mass="8280" checksum="078993D8B5047814" modified="2017-01-18" version="1">MTSSRAARRRHLPTSPFKPPSVGPEPETYALDDQVTHEKYGLGRVIGVEEGVAVTIDFGLPILRIVAPYHKLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1P6</accession>
    <name>A0A1H6D1P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78536">
        <property type="protein sequence ID" value="SEG78536"/>
        <property type="gene ID" value="SAMN04489712_11289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="18402" checksum="33E2A8294A2312D0" modified="2017-01-18" version="1">MLDDLLERLLSGEGGPAADQVGLGMLLAAAHNQSRERLNQALRPLGINVRGFAVLLALPMYGPVSQRDLIGHIGIDKSTMVRLIDELEDGGLVSRERVPQDRRAYSIVLTRRGEQTLTKARRIAEQTDEHIFGRLTEAERQHLVELLRRLAEHTAPPRPDASHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2N7</accession>
    <name>A0A1H6D2N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_112234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79547">
        <property type="protein sequence ID" value="SEG79547"/>
        <property type="gene ID" value="SAMN04489712_112234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004379">
        <property type="entry name" value="UDP-GALP_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00031">
        <property type="entry name" value="UDP-GALP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="4">
        <location>
            <begin position="151"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG79547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="45191" checksum="3688D54EFAC3DCE3" modified="2017-01-18" version="1">MYVNADLVVVGSGFFGLTVAERCANLFGKRVLILERRDHIGGNAYSESEPETGIEVHRYGAHLFHTSNERVWEYVNRFTAFTDYRHRVYTNFKGRVYSLPINLGTICEYFGRAFTPDEARALVAEQAAEVSDPRNLEEKAISLIGRPLYEAFIRGYTAKQWQTDPRELPAEIITRLPVRYTFDNRYFNDKYEGLPVDGYTAWLERMADHPNIEVRLGTDFFEQRGDIVGNVPVVYTGPLDRYFGYAEGELGWRTLDFDLEVKPTGDFQGTPVMNYADEDVPYTRIHEFRHFHPERDHYPADKTVIMREYSRFASRDDEPYYPINTPDDRARLLRYRQMAKGEDGVLFGGRLGTYKYLDMHMAIASALNMVDNRLRPHFAEGARLVSGGMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5G9</accession>
    <name>A0A1H6D5G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80629">
        <property type="protein sequence ID" value="SEG80629"/>
        <property type="gene ID" value="SAMN04489712_113117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011396">
        <property type="entry name" value="UCP030850"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030850">
        <property type="entry name" value="UCP030850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="295" mass="32413" checksum="6332D131F45AB454" modified="2017-01-18" version="1">MDWVERVLAIRQWSHHGERAPHKPLLLLYALGRYQREGAGSIPYSAAEEPLNRLLREFGPPRHARSTMAYPFHYLTSDDRLWQVDTDDGPGSPGPRVGLLRSAHARGRLHPELAAALDADPGLLGRLARALLDANFAPTLHADICLETGLDLAGAELPAAVESRLPPRDPAFRERVLDAYGYRCAFCDYDGLLAEVPVGLDAAHVRWRSYDGPDDPDNGLCLCALHHRLLDRGVLGLTPDRTITVSGRFSARAPVASLLVLDLSGRPARAPRSGPRVRPDHITWHTAQVFRAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7W0</accession>
    <name>A0A1H6D7W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81380">
        <property type="protein sequence ID" value="SEG81380"/>
        <property type="gene ID" value="SAMN04489712_11442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295608" evidence="2">
        <location>
            <begin position="37"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="487" mass="49398" checksum="7A82DDE986821FD2" modified="2017-01-18" version="1">MRPTVSSRAVLTRAAVVAALLAATASPALPASPAAAASAAGPFEPLPPRNPYAGPLGTATMHGDTASSDATPLAGPGAGSLTSRRVALAAACPTVLAGADGYPVALCTEIFGQAPTVHLLDPASGDSVAELGLTKGSLLGGVYAYLDHADRLVVVDGTRDLLRIGHRRTSSGGWELYVASRLPLDAVVAEDDSVVGLSPDWQGRVWFATGGGVVGTADDTTGVVKSLALPAGEKVANSISTVPEGTAVTTTHATYLLRADATGTPSVVWRQVYDRGPGRKPGQLSWGSGSTPTFFGPHGTDYLTIVDNAAPTVNLLVYASGTGQQICKVPVLKAGGSGSENSPVAAGSTVFVASTYGYPYPVLPDDAGPSVPPSADFTGGLSRVNVTASGCTLAWDTVVRSAAVPRLSTADGLLRTVVRKPVIPGTTSTTILDTYVYTEIDPATGAIVRTKTLGTGFIYDTLQMVGTITPGVVYQGTTTGVVRIANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDI0</accession>
    <name>A0A1H6DDI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82815">
        <property type="protein sequence ID" value="SEG82815"/>
        <property type="gene ID" value="SAMN04489712_11589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="518" mass="54467" checksum="645A8CA5944E7980" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHH5</accession>
    <name>A0A1H6DHH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84602">
        <property type="protein sequence ID" value="SEG84602"/>
        <property type="gene ID" value="SAMN04489712_11732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG84602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="60" mass="6568" checksum="BC12950D0C3C3C85" modified="2017-01-18" version="1">MEPVDAETCVLLCGANNLDEIVVWVALMDIGFEVHDPPELVERIGAMADRLRAASRTTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJN0</accession>
    <name>A0A1H6DJN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84856">
        <property type="protein sequence ID" value="SEG84856"/>
        <property type="gene ID" value="SAMN04489712_11780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="199" mass="21148" checksum="ADBC25B4BCCFC9BB" modified="2017-01-18" version="1">MPTGTALRDARRQLFDAAERILLRNGPSALTSRAVTDEAGCAKGVLHRHFADFDAFLAEFVLDRIDRMDAQAAALREAAGTGTVAGNLTDALRALFGSVAVAIVALVTFRDELRARLRRTWPAGVPVLTEACTMIASYLTAERELGRIAADADVDTLAAMLIGAGHLLFADRKGAPPQAEAVHKMVTTVIAGVTREPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKK9</accession>
    <name>A0A1H6DKK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85651">
        <property type="protein sequence ID" value="SEG85651"/>
        <property type="gene ID" value="SAMN04489712_11853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="7"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114587" checksum="59CB3B3F31E740D9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMN5</accession>
    <name>A0A1H6DMN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86570">
        <property type="protein sequence ID" value="SEG86570"/>
        <property type="gene ID" value="SAMN04489712_119114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296051" evidence="1">
        <location>
            <begin position="30"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="175" mass="19369" checksum="689523097C6170A9" modified="2017-01-18" version="1">MPSQRTKRAAVLGATVVVLGGLMVPTALPAVGRSAPTQNAHGATHDALKEFERLRQRQADAWARQDGAAFAATFTLNGDVVTFNGDHLRTRQGIAVGMQYYFDKYIPDNTIRYLDEHVRFAGPRLAIIVRTTCLVDAGQSDCRDDSLSTNTNVMTRHQGRWLQESFQNTRVDPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRP5</accession>
    <name>A0A1H6DRP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87949">
        <property type="protein sequence ID" value="SEG87949"/>
        <property type="gene ID" value="SAMN04489712_12143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1430" mass="151347" checksum="8E91DBDC54078208" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRS2</accession>
    <name>A0A1H6DRS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87979">
        <property type="protein sequence ID" value="SEG87979"/>
        <property type="gene ID" value="SAMN04489712_12150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG87979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="21970" checksum="96480621678CCFAF" modified="2017-01-18" version="1">MTAPSPRSPGELPAWFEPFCKAEFRVLARVVMAAGGTLQEAEDAAQDTFVEMLRRVMDGERIRSPRPYARKSVLNRFADVRRRDRRGHELAVKGGYALPEAWQDLRLEEWEGRQWVDQLLAHCPPAQQKVMRCVLDGLSGREIADLLGKTPATVRKNHQLARRRLRPLVGQEYQVAARGDAGSDVSQIDQKDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTE9</accession>
    <name>A0A1H6DTE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, FadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88520">
        <property type="protein sequence ID" value="SEG88520"/>
        <property type="gene ID" value="SAMN04489712_12221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG88520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="30347" checksum="F3FB82383550DD93" modified="2017-01-18" version="1">MTGGRIPDASEATAVRQAVRSPKTAELIASQLRRVIVRGELRPGDRLPSEAQLMERFGVSRPTLREAFRILESESLISVLRGSRGGARVTAPQAAVASRYVSLLLQVRNTTIADVYEARMVLEPACARLLAQRRTDADLRDLRDHIEHLHQVVENRGRTADPLEWSRLTYRFHELVLQRSGNRTLALHGELLHDIVSTHMAITVSRDIHDPATIGLFRRTVRSYRKLVDLVEARDSEGAERHWRTHMEAAAEWLMGTGLRGKTVVDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVW9</accession>
    <name>A0A1H6DVW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88745">
        <property type="protein sequence ID" value="SEG88745"/>
        <property type="gene ID" value="SAMN04489712_12271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG88745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="26675" checksum="152CD110BA390679" modified="2017-01-18" version="1">MRTQRQPALRTTGLRKAFGDHVAVDDVGLTVPAGSFYGLVGPNGAGKTTTLAMAVGLLRPDAGRAEIFGVDVWRSGVEAKSLVGVLPDGNAMPERLTGREVLTYLGLLRGLPPGVVAERAAELLSVLELDSAERALVIEYSTGMRKKIGLAVALLHAPRLLVLDEPFEAVDPVSAATIRTILRRFVTGGGSVIISSHVMALVEQLCDHVAVISGGRVAAAGPLAEVRGGGSLEEAFIELVGARAEVREGLAWLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWJ1</accession>
    <name>A0A1H6DWJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89712">
        <property type="protein sequence ID" value="SEG89712"/>
        <property type="gene ID" value="SAMN04489712_12437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="17084" checksum="192CCD90C176AAB3" modified="2017-01-18" version="1">MDRTETERAPVASAPWAGRGPSTAERQIREIRRRYPRAMVWLGEETGAWWALPDYYREHYPQSPRPVPARLTQRPPVGDISQTPRLARAQQPRLGEGGAVARSMPPHHQASRVTVPTSPPAPPPRGRHAARRDERGMWRRAGVRLGLLQVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWS6</accession>
    <name>A0A1H6DWS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty-acyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89721">
        <property type="protein sequence ID" value="SEG89721"/>
        <property type="gene ID" value="SAMN04489712_12440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="448"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="544" mass="58531" checksum="55F57C5A9AB6AC8F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX58</accession>
    <name>A0A1H6DX58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89664">
        <property type="protein sequence ID" value="SEG89664"/>
        <property type="gene ID" value="SAMN04489712_12420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="101"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG89664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="183" mass="20393" checksum="5CA09A7D138FBDCD" modified="2017-01-18" version="1">MDDEAERFTAIYDACRQHVWAYAVSRAGRQIADEVVSETFTIAWRRLADVPESPLPWLLGVARNVLRDGHRAQARRAALEAESRAWAGRGEDDIADKVAERLAVLRAMAALPEDDREILILIAWHGLTPREAARVVGCSAPALRVRLHRARKRLVRAVDAAAESRGAVHPVRPRMPITGEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX81</accession>
    <name>A0A1H6DX81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89809">
        <property type="protein sequence ID" value="SEG89809"/>
        <property type="gene ID" value="SAMN04489712_12473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041176">
        <property type="entry name" value="VWA_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18571">
        <property type="entry name" value="VWA_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="46"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="45709" checksum="B86291EF77F3711C" modified="2017-01-18" version="1">MPEFTVKVDQNRYLPEGGREVHAIVTVEASGSGVGPVGGAPGDPAAEVIIIDTSGSMSFGGKMAEAKRAAKAAVDALRDGVHFAVVAGFNFARPVYPKGETMAVADARTKEEAKREIGRLEAAGGTAIGSWLRMAGKMMAAQGGGGVRHAILLTDGKNQHETDAELDVALAEVNGGFVCDCRGVGTDWEVGELRKIASTLLGSVDIVADPRDLEADFRAMTENAMGKSVADVALRVWTPQHGVLKFVKQVSPSLADLTDKRTESGPQSGDYPTGAWGDEVRDYHLCVQVPPGEVGRQMRAAWVKLVAPDGAGGEQVLASGNVLAEWTDDEARSTQINARVAGYTGQAELAEAIQEGLAARREGDLDTATARLGRAVVLARQAGNQQIAGLLDKVVDVIDPVTGTVRLKKDVDKADEMSLDTRSTKTVRTRKDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYN3</accession>
    <name>A0A1H6DYN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90437">
        <property type="protein sequence ID" value="SEG90437"/>
        <property type="gene ID" value="SAMN04489712_12637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="22174" checksum="B0A67BAA84D78242" modified="2017-01-18" version="1">MDLFEAIRTTRAMRRLDSDRPVSDADVRTILEAALKGPSGGNQQPIRWLVIRDQDTKDRLQEIYQRCWNRGRKPYAAEPGRIAPAVLNSADHLAANLHRSPVLILACADTGPQGRRHDASVYPSVQNLMLAARALGLGTTLTTAHLFEEDAVKELLGIPPHVTTYALIPVGHPLGRWGEPKRRPLDEVSYHDRWGQAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZI3</accession>
    <name>A0A1H6DZI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90742">
        <property type="protein sequence ID" value="SEG90742"/>
        <property type="gene ID" value="SAMN04489712_12725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="31490" checksum="3D0C29343AF8B382" modified="2017-01-18" version="1">MPHRDTYTRDPLIRTFGAFLRSLRESRRLTRQQLADALGCGPEWIEKLETAQRPPSEQTAKDLDTFFLGLPEETQGPFWKAWNEIRGQGRHLALLPGFSGYVEHEAKASSLHIFGAMVLHGLFQTEEYAYEVLKKGRTPEQAKQLVATRMERQNVLTRKDPPHIVAVFDAMALRRKIGNTEVMKDQLRHLIDLAEDHPNITIQLVPEHVGSYQGVMGAFTILGVSDGPNLVYVEGYTTGQLIDHPDEIQAYTRNYDLIRGTAASADESLSMLHATLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZM3</accession>
    <name>A0A1H6DZM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="9">PEPC</shortName>
            <shortName evidence="9">PEPCase</shortName>
            <ecNumber evidence="4 9">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ppc</name>
        <name evidence="12" type="ORF">SAMN04489712_12737</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="4 9"/>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90782">
        <property type="protein sequence ID" value="SEG90782"/>
        <property type="gene ID" value="SAMN04489712_12737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG90782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="917" mass="100174" checksum="7D58E79CF65AF6D6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0S1</accession>
    <name>A0A1H6E0S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-6-methylguanine DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90753">
        <property type="protein sequence ID" value="SEG90753"/>
        <property type="gene ID" value="SAMN04489712_12728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG90753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="92" mass="10290" checksum="EAF8405FD4E26201" modified="2017-01-18" version="1">MTRHDRYKIHSLGRYDRIRPTSTTYGELAARAGLERAARAAGQACAQNLIAPVVPCHRVLPAAGGKGLKRFGGYYYGPERKEWLLHHEATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1J3</accession>
    <name>A0A1H6E1J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91508">
        <property type="protein sequence ID" value="SEG91508"/>
        <property type="gene ID" value="SAMN04489712_12941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="26280" checksum="DAC6CC31DF142951" modified="2017-01-18" version="1">MPAELCELTVHIDTGRWNETVLDAVDLVVPDGKITALLGESGCGKSMVAAALTGSLPDSARSTGQVRVDGEPVRGQREWRRLHGGTVGLLPQDGVTAFRAEDTVGAQLHALEDRYRRWSFDRACASAWYPTELADLYPHQHSGGQIQRAALAAALLPEPRVLIADEPTASLDTQTAYGIWAALRRYADAGAAVLVITHDVPMLTSAKIADHVALMRGGKVIATGGLTDLAALDDPYVRGFFQPNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1W3</accession>
    <name>A0A1H6E1W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91648">
        <property type="protein sequence ID" value="SEG91648"/>
        <property type="gene ID" value="SAMN04489712_1308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="26658" checksum="28C43418810F97B7" modified="2017-01-18" version="1">MSGDPNTLLLTRDISVQYGGVRANDEVCIEVGAAEIVGLIGPNGAGKTTFVDAVTGFAPHTGTIELDGVRLDSVPAHRRRRLGLARTWQSGELFTDLTVAENLAVSVDPPGLRGLVADLGRRRKRADEDIQEALSLVGLEAMAGRRPDELSLGRQKLAGVARALVGSTRVLLLDEPAAGLDTEESAEFGHELRRIAASGPGVLLIDHDMTLVLDVCDRVYVMDFGKIIASGAPSDVSSDAQVIAAYLGSPVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2X9</accession>
    <name>A0A1H6E2X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aromatic ring hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91897">
        <property type="protein sequence ID" value="SEG91897"/>
        <property type="gene ID" value="SAMN04489712_13119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004925">
        <property type="entry name" value="HpaB/PvcC/4-BUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024719">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024674">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117">
        <property type="entry name" value="PTHR36117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03241">
        <property type="entry name" value="HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11794">
        <property type="entry name" value="HpaB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000331">
        <property type="entry name" value="HpaA_HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpaB_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="HpaB" evidence="1">
        <location>
            <begin position="260"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="472" mass="51903" checksum="07AAAD680302FA36" modified="2017-01-18" version="1">MLTGDQYLESLRDGRRLFVNGHAVPDVTEEPLLRGGALAAARGYDQHYQPGDDAFGPYFFIPGSVEELRATQERQLHWDFPTISTSNGLLMVLTAASRMRPDFPQYAERALAYFEESKRRDIRIVQTITDAKGNRSLPPAQQDDPDLYVRIVDRGSDGIVIRGAKLHISSAAITHELMVMPTKRMKPGEEDYSVAAAVPVNAPGVRVINASFAPRPDLDPDFFPYSSRHVMTEGFVVFDDVFVPNERVFLAGELEHSATFAHSLGLWERLGSVGSYVRLADTLVGLAQLVAEANGLQRIGHIKDKIAEMITYATLIRAGFEAAMHHATFTPEGWASPDEMFTNAAKYHAAAQFSLMVRHLHDIAGGAVLTAPSMADLRNPETGPDLQKYMRTMKGVDADYRMRLFHTIRDFTADAFGGWKHVTVIQAGGGLYAQKVVVSNHYDMDAAKALALETAGITPDGKVLTSLAGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E511</accession>
    <name>A0A1H6E511_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_13528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92780">
        <property type="protein sequence ID" value="SEG92780"/>
        <property type="gene ID" value="SAMN04489712_13528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="445"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG92780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="536" mass="56233" checksum="9DD28C1A9A2CE45D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E686</accession>
    <name>A0A1H6E686_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_13523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92763">
        <property type="protein sequence ID" value="SEG92763"/>
        <property type="gene ID" value="SAMN04489712_13523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG92763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="114" mass="12277" checksum="2DE31F103B774C7A" modified="2017-01-18" version="1">MPFLIGDACVDVKDKTCITVCPVDCIYEGDRKLYIHPDECVDCGACEPECPVTAIYIVDDVPDELTWAIDDNTRFFSEPLPGRSTPLGSPGGAATIGPIGTDTPYIAGLPRNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6V1</accession>
    <name>A0A1H6E6V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske [2Fe-2S] domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92686">
        <property type="protein sequence ID" value="SEG92686"/>
        <property type="gene ID" value="SAMN04489712_1351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="28"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="119" mass="13465" checksum="6C0D0834D35A167A" modified="2017-01-18" version="1" fragment="single">MTTSQTTPDDEVRVIEAVAPPTRYARGWHCLGLLEHFNDGRPHAVEAFGTKLVVFADSTGRLNVLDAYCRHMGGDLSRGEVKGDEIACPFHDWRWSGNGRCVRIPYSRRVPPRARTRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9W2</accession>
    <name>A0A1H6E9W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93889">
        <property type="protein sequence ID" value="SEG93889"/>
        <property type="gene ID" value="SAMN04489712_14122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="313"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="646"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="864" mass="97068" checksum="B7601BBB81EC11A9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB63</accession>
    <name>A0A1H6EB63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94501">
        <property type="protein sequence ID" value="SEG94501"/>
        <property type="gene ID" value="SAMN04489712_1488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="488" mass="53781" checksum="BF18EAD99686813A" modified="2017-01-18" version="1">MEIADLTPAERRVWRAFPRGEVVDFRRSDDEDAEDGHTWGPERTVRAKALRALLLAGTAEEGQVAALRVVGARITGVLDLQYAAVEHSVRLWGCHFERAAILYGAHVRQLNLSHSYLPALEAATLHVEGVLRLTDCRVPGQVRLGGARLSGALFLERARLGDEDEDPDDVLHLNHATVDDDMWAPGLTVHGQIQLNGAKVSGTVNLDEAMLINPGGTVLDARSFAVGTDMHAVRMRTQGRVNLRGATVAGGIDLTGARLSNPGGVALRASSVIARELWLRNAPRIEGTANLRRSQFELLHATPDVWPDAVRLDGLTYNALAPHLPAKQRLPLLEREEDGYVPHTYEQLTAAYRRIGDDAAARMVQLAKQRRHRTTLPWYAKLWGHLQDVTVGYGFRPMRAAAWLLTLLLTGTIAYTLKQPPALKAGEAPAFNPLFYTFDLLLPIIDFGQEKAFTPQGWYQWLSYALILAGWILATTIVAGITRAVSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SEM1</accession>
    <name>A0A1H5SEM1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrR</name>
        <name evidence="7" type="ORF">SAMN04489712_101156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48281">
        <property type="protein sequence ID" value="SEF48281"/>
        <property type="gene ID" value="SAMN04489712_101156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="6">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF48281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23815" checksum="CF81CD0D7257C23B" modified="2017-01-18" version="1">MNAASRPVQPAEARDAERDAGHKAVLEAPDIRRALTRIAHEILERTKGGADVVLLGIQTRGVTLARRLAARLEEVEGRPVPWGSLDVTMYRDDLRMRPARALGRTDLPPEGVDDRIVVLVDDVLFSGRTVRAALDALNDLGRPRAVQLAILVDRGHRELPIRADYVGKNLPTSMRETVRVLLAENDERDAVLLGPAAPGDTRGGAPDGEASHSDRKSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SKM7</accession>
    <name>A0A1H5SKM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51004">
        <property type="protein sequence ID" value="SEF51004"/>
        <property type="gene ID" value="SAMN04489712_101249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="37"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF51004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="245" mass="25134" checksum="558542858FB3A699" modified="2017-01-18" version="1">MGTRGTGRVRTAVVWDALRRTVDELARATGRSLDVIDAGGGTGGFAVPLAGLGHRVTVVDASPDALAALERRAAEAGVAVDSVQGDAGDLPDLIGPGQADLVLCHSVLEYTDDPAAAMAALAGTVRPGGAVSVLVAGRLATVLHRAVAGHFDDARRALADPAGRWGERDPVPLRFTRQTLTELATGAGLRVAELHGARIFADLVPGGVLDGDPEAVESLIALETAAAVHPVLRDLATQLHLLARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SZG2</accession>
    <name>A0A1H5SZG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55919">
        <property type="protein sequence ID" value="SEF55919"/>
        <property type="gene ID" value="SAMN04489712_101423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF55919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="383" mass="43422" checksum="0E004EB8C9BF84F9" modified="2017-01-18" version="1">MTTGRDSIGTVEELHALASKITGLTDFGEDPYLDGLEVLLHSYAEDAALTPLGNRVKRAFLRGALTARLLSEEAWKRHPEHADVRIERPVFVTGLPRTGTTALHRLLTADPANQGLEVWLTEVPQPRPPRETWADDPVFQAVQSGYERHHLERPEFMGVHYMSADMVEECWQLLRQSMQSISFECLAHLPTYSAWLQERDWTSAYRRHRRNLQLIGLPDAGRRWVLKNPSHLFALDALLEVYPDALVIQTHRSPRTAMASMCSLAAHATEGWSQMFTGAVIGRDQLELWSRGLERFRAERAGHDPARFFDVEYDDFVRDPLGTIEAVYAHFGLPLSDAARAAMARLHDESHSGAARPAHRYRLSDFGLTPEEVDERFAAVRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TC58</accession>
    <name>A0A1H5TC58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-methylcitrate dehydratase PrpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60340">
        <property type="protein sequence ID" value="SEF60340"/>
        <property type="gene ID" value="SAMN04489712_101561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="11"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="279"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF60340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="480" mass="50368" checksum="D1157DC45131B046" modified="2017-01-18" version="1">MTERPSYSRVLADFAAGTSFADLPDDVVDSVRKRVLDVLGLCVAAHRLPTSTAIVQYVRDQGGAQQAHVVGGGPGKVPAALAALANGVLAHSLDYDDTHLPSVLHPSASVVPAALAAAELADASGEELIRAVALGLEICVRIGMAGYDPDAGNSIFFEHGQHATSICGALGGAVAAGLLLGLSRDGLMDCLGVAASMASGVIEANRTGGTVKRLHCGWAAHSAVTAADLVRRGFTGPPTVLEGRFGFFQAFLHGDYDGDELTCGLGVRWHVPGIFFKPYPANHFTHAAVDAAMALREQGLDADRVESLTLGVPAPVIRTIGQPIEVKRAPETGYQAQFSGPYAVAVGLLGGGGLGAALADYTDELARDPRRRELMARVEVVADEQATKIFPQQFPAVLTARDTDGRVWRHEVLANRGGPDRPLSEAELARKFTDNTTGWLPPEAAGRVTDLVRRLAELEGAAERLLRPLAEFDTGTGDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TSI0</accession>
    <name>A0A1H5TSI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-desosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65743">
        <property type="protein sequence ID" value="SEF65743"/>
        <property type="gene ID" value="SAMN04489712_101730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="DUF1205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030953">
        <property type="entry name" value="Glycosyl_450act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="DUF1205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04516">
        <property type="entry name" value="glycosyl_450act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1205" evidence="4">
        <location>
            <begin position="222"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF65743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="443" mass="49589" checksum="105D5BF79C63CCC0" modified="2017-01-18" version="1">MKVMFASLEGSHFQLMVPMAWALRTAGHQVRVVCKRGLVDAVAQAGLTAVPVDCPPWQEGLGRFHQEALARCNELETTELERIGPKAPGVADAVRARPTWETLLAYESLVVPALWARLNRDEMIDGLVEYARFWQPDLVLWESFCMGGPVAALACGAAHARMVSGPDMALQMGPRREFVRRLRELPPENREDPTADWLDWTLERVGCDRRFDETMLTGQWIIDSRPPSMREDLGVPTVPVRYVPYNGRCVVPAWLREPPPDRPRVCLTLGTSIDGDYALFDLNTMLNALMRTLADMEIEVVAAIAAKQRALLRQIPDNVRVVDFVPIDDLLPTCAAVVHHGGYQTKATAELHGVPQVIVTGWEWVSEGMGRDYEGQGTLLSIPLREFTAELLRERLERVLEDPSFAANAMRVREELLAMRTPNDIVPTIERLTAERLLEGIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TVF5</accession>
    <name>A0A1H5TVF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66776">
        <property type="protein sequence ID" value="SEF66776"/>
        <property type="gene ID" value="SAMN04489712_101761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF66776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="23317" checksum="CAEA1A837A613634" modified="2017-01-18" version="1">MRPYKGVSAAERMAQRRAAIMEAAWDLLGTEGWQAATVRGISSRAGLNDRYFYESFTDLGALLLAVVDDQAARGITAILEVARSAPRHLRTRTQVVVTAIFDFLAEDPRRAQVMAREFPASPLLQSRKHEIVQAVMEIFIAQVHELLDEVPLSPEDLRLTALTITAGIWETITLWLRGDLDTSRDHLIDYIVALLMATTALPPALNAQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TYD6</accession>
    <name>A0A1H5TYD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Delta-9 acyl-phospholipid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_101769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67041">
        <property type="protein sequence ID" value="SEF67041"/>
        <property type="gene ID" value="SAMN04489712_101769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="60"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF67041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="35240" checksum="6D74F7A77E4C32CB" modified="2017-01-18" version="1">MTPSTSVGSLHAPEPVGPMEDEESRPWERILIGVFITVPLLAVAAAVPVAWGWGLGWRDVVITAVLYLVTGFGITAGYHRHFTHGSFKAPRPVRYALGIAGSMALEGPITRWVADHRKHHRYSDRDGDPHSPWKYGRSPGGLVRGLLHAHMGWMFDKEQTPKRRYAPDLLADRDVALMTRLFPLWVAISLLLPAVVGGLWSWSWQGALSGFFWGGLVRIGLIHQVTWSVNSLCHVFGKRQFATRDRSTNVWWLALPSLGESWHNLHHALATSARHGVLRGQLDPSAALIRLLERLRLAYDVRWPDPARVAAKRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U1U2</accession>
    <name>A0A1H5U1U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69102">
        <property type="protein sequence ID" value="SEF69102"/>
        <property type="gene ID" value="SAMN04489712_101840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF69102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="14162" checksum="23800327B5CE86A4" modified="2017-01-18" version="1">MIYLVYRMKLSLKARGDMRGFWKWLEDRERWFYRDLPMVREVRWYYSVIGDVYVVENWAAFDNEAGWGEYRSALATLKADDAWETQRVSQDEWWEFLDTRIVTDLPVKVGFRHHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UWE4</accession>
    <name>A0A1H5UWE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transglutaminase-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79389">
        <property type="protein sequence ID" value="SEF79389"/>
        <property type="gene ID" value="SAMN04489712_10262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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</entry>
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</entry>
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    <sequence length="553" mass="58573" checksum="06E1300CBBD7D704" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VN93</accession>
    <name>A0A1H5VN93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88663">
        <property type="protein sequence ID" value="SEF88663"/>
        <property type="gene ID" value="SAMN04489712_102387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF88663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="22562" checksum="0B264DE5ACF165B7" modified="2017-01-18" version="1">MGINGHGEGGGGRQWARADATRQALLQAAQEVFADRGYSDAGIAEIVERSGISVGSLYHHYGGKAGLYLALWEDYTRAQEEGATQAVSAARKSGERDPIALFIAGARAYLRVCWEQRDVARLFHEGEGPSGFSLMRRGRARQWIAQNTKLLRGLNGGPDGAGGRRREVLSLVLTNVIGEAGREIAGAESEQAADEIIEEVCRILIRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VTM2</accession>
    <name>A0A1H5VTM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90642">
        <property type="protein sequence ID" value="SEF90642"/>
        <property type="gene ID" value="SAMN04489712_102456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF90642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="223" mass="23764" checksum="A6471C987068EBF5" modified="2017-01-18" version="1">MPARVVTLSATFGAGGSVIGPAVAERLGVPFVDRAVPATVAAEIGCTLEEALAHDDRAEHGLGRILAGAARVPVVALGGMDVHLSDRALVPAEEFVARTEQVIRQIADGGGVILGRAAAVVLGDRLGVLHVRLDGPVDRRLERALRDFADEPGPGPGRERTEAERRRSVRRALDDNDRARTAYVRHFYRVDPASPRLYHLVIDSTRLPVDAVTELIVSAADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VWQ6</accession>
    <name>A0A1H5VWQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpD</name>
        <name evidence="13" type="ORF">SAMN04489712_102495</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91684">
        <property type="protein sequence ID" value="SEF91684"/>
        <property type="gene ID" value="SAMN04489712_102495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="155"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="163"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEF91684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="476" mass="52064" checksum="24C4FDDCADB624F8" modified="2017-01-18" version="1">MTAQVETATAAGRVARVIGPVVDVEFPADAMPEIYNALNVEVTLGEETKTLTLEVAQHLGDNMVRAISMQPTDGMVRGAQVTDSGEPISVPVGEVTKGHVWNALGETLDVPTASLKVTERWGIHRKAPAFDQLESKTEMLVTGIKVIDLLTPYVKGGKIGLFGGAGVGKTVLIQEMIRRVAKNFGGTSCFAGVGERTREGNDLWVEMEEADVLKDTALVFGQMDEPPGTRLRVALSALTMAEYFRDVEKQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGVLQERITSTRGHSITSMQAIYVPADDITDPAPHTTFAHLDATTVLSRAITEKGIYPAVDPLDSTSRIVDPQVIGREHYEVSQEVKRILQKYKELQDIIAILGIDELSEEDKVTVQRARRIERFLSHPMFVAEAFTGQPGVFVELDETIASFKAIAEGKYDHIPEQAFFMCGGIDDVEKKAKELAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W842</accession>
    <name>A0A1H5W842_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphocarrier protein HPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95634">
        <property type="protein sequence ID" value="SEF95634"/>
        <property type="gene ID" value="SAMN04489712_102625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009287977" evidence="1">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="HPr" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF95634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="89" mass="9239" checksum="54736EBB21190D12" modified="2017-01-18" version="1">MAQRHVKIRSKVGLHARPAALFVQAAARAPMDVTVAKLGGNPVNAKSILAVLGMDARHGEEIVITAEGESADQVLDELEAAVNVEAGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W894</accession>
    <name>A0A1H5W894_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95476">
        <property type="protein sequence ID" value="SEF95476"/>
        <property type="gene ID" value="SAMN04489712_102621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="155"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF95476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="33708" checksum="D04BEFDCFAD8E6CC" modified="2017-01-18" version="1">MRKTNGRDSGGTGEATAPPAASPSTKDAPLSTVVRVRSLLPSLPPAERRVAQRVIDDPEGVANSTITELAHACGTSETTVIRFCRAIGFTGYPELRLTLATEAGRAQSAAGGRVIGSDISPDDSLEQIVEKVTFADARAVEETAAQLDIKVLEQVVDAVVAASRVDVYGVGASAFVALDFQQKLHRIGRHCSAWSDAHIMLTSAAVLSPGDVAMGISHTGATVETIDALSVAKGRGVITVAVTNFPKSPIAEVADLVLTTAARETTFRSGATASRLAQLTVIDCVFVGVAQRTYGTTRKALEATFEAVRSRTVRPDRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XCL4</accession>
    <name>A0A1H5XCL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4236 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09511">
        <property type="protein sequence ID" value="SEG09511"/>
        <property type="gene ID" value="SAMN04489712_103195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025330">
        <property type="entry name" value="DUF4236"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14020">
        <property type="entry name" value="DUF4236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4236" evidence="1">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG09511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="63" mass="7133" checksum="75F29482CD42F41F" modified="2017-01-18" version="1">MGWGYRKSIKMGPFRINLSRTGVGHSVGGRGARYTKTADGRRQMTLRIPGTGLSWRRTLGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XDH1</accession>
    <name>A0A1H5XDH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09834">
        <property type="protein sequence ID" value="SEG09834"/>
        <property type="gene ID" value="SAMN04489712_103207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG09834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="13311" checksum="BD1AED278CF8F218" modified="2017-01-18" version="1">MPVPRPLRERCRDFLDLFEEIRYIFPASHPGGGSHFVFVVTDTAITVISTGTLSRTKPKSVWGTYPRRTRIGPVDVGGGAFFEFGGVDFEVDDEYVPVVNAADAEVFARDTLPEDPHPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y030</accession>
    <name>A0A1H5Y030_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17311">
        <property type="protein sequence ID" value="SEG17311"/>
        <property type="gene ID" value="SAMN04489712_103492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="13985" checksum="C7C9692AA98B0A9C" modified="2017-01-18" version="1">MRFRDRFGIRKWRGVRVAKLDREATDADIEALIAFARSRQGVEFFVEPETFATDTTAVAVASDGEWTRRRVGAPQVIHKVARDLGLPVYDVQLVGYPPRMRAWNERNRDRRLDPGSPGEAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y1E1</accession>
    <name>A0A1H5Y1E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mce-associated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17585">
        <property type="protein sequence ID" value="SEG17585"/>
        <property type="gene ID" value="SAMN04489712_103502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="20465" checksum="C3D20718930E6E1F" modified="2017-01-18" version="1">MAGTGETSPHDRDASRPARLRGLLRGRAAGRLILAAAVAFAGWGGWSYWQAGRDEAVDFGKTRDEVLAAGRQAVADLNTMDATQVDQSLRRWLDASTGPLREELTRARDRNRQQVQQSRTSARGTVTDAAVLQLDPRAGTAQLIAMVRVEITPASGAGASTDRKRFEAGLARTPDGWKLRSLTAIPVNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y312</accession>
    <name>A0A1H5Y312_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG18087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG18087">
        <property type="protein sequence ID" value="SEG18087"/>
        <property type="gene ID" value="SAMN04489712_103521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290091" evidence="1">
        <location>
            <begin position="41"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG18087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="233" mass="23430" checksum="4B3DED89124554F1" modified="2017-01-18" version="1" fragment="single">LSWNDFLKGNTVMRKLVRNALVAGAATTAAVSLAGTPAFAGPGTWNVTPTSTIFSATSTNPTLTNPRNSASLTCTSVTASGSTVATSLNDAGFVHAISPEVGHIDVPDTVANVISSSWTGCRGPINLTFGVTHAGTWTLQAISENSSTHVIKGRISGVHATIAGTGCSAMVSGSARGTYDNSAKTLTISEPGGTSGGLIVSGASCLGILANGDKPSFNATFSVTGNIAVHRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YIN7</accession>
    <name>A0A1H5YIN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23407">
        <property type="protein sequence ID" value="SEG23407"/>
        <property type="gene ID" value="SAMN04489712_10411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="31607" checksum="B609501242D16A0F" modified="2017-01-18" version="1">MNPVESLDPDASILHWIAFDLRFWRTKSGLSLAQMAKIMNCTKGTVSNLEHARPGYRLDERQAKAIDEYFGLGVHFQRMVRYAKSGHDPDWSRQHTLYEQRALTIRTYEAMVVPGLLQTEDYARALLTAGYADDVETWVKRRMSRQAVLAKSDRPHLWVIISQNVLDWPVGGAAVMAAQLARLLEISEMPNVTLRVLPRSVGAHLGLEGTFKIVSVKEGDVVYMEACGGGRLTQDLTDVRKYHVRYDRIGADALPRNSSRDLIRRAMETYHDAVAQEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YX51</accession>
    <name>A0A1H5YX51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28879">
        <property type="protein sequence ID" value="SEG28879"/>
        <property type="gene ID" value="SAMN04489712_104242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG28879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="294" mass="32178" checksum="309C80E3A13720E1" modified="2017-01-18" version="1">MTARHDDAVPAGLRLPDAPVTLSTASVYPEKVPSAFEIAAALGYDGVEVMVATDAASQDLNVLRRLSDYHQVPIKSIHAPCLLLTQRVWGREPWGKLVRSKEVAEELGAEVVVVHPPFRWQREYAREFVEGLARMQDETDVVFAVENMFPVRARGAEVGMYLPDWNPVDQDFPYVTLDLSHTAVSGSDALEMASGLGDRLRHVHLADGVGVTNKDEHLVPGRGNQPCDAMLEKLAGDGFGGHIVLEVNTRRAASRGERLEDLAEALAFTRLHLAAADRTWEVTPAGEVSRRGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z9Y8</accession>
    <name>A0A1H5Z9Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclic nucleotide phosphodiesterase class-III family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32884">
        <property type="protein sequence ID" value="SEG32884"/>
        <property type="gene ID" value="SAMN04489712_104430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07402">
        <property type="entry name" value="MPP_GpdQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026575">
        <property type="entry name" value="GpdQ/CpdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG32884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="28547" checksum="FE7E438DE97B9C3D" modified="2017-01-18" version="1">MTIIAQLSDIHLAVGADGEVDDRSGPVRALRNAVSSLLALPERPDCLVLTGDLTDNGLPAEYARLHALLSPLPMPVFPLPGNHDDRAALRSVFADHVAVVAAHDDRDPQAPFQYAVEVAGIRLVCCDTTVPGQAHGELDAGRLAWLEAALAAGPGTPTVVATHHPPFPVGVRFLDELALCDPAAFGAVLARHPQVERVISGHVHRASAGSVGGVTATTCPSTYRQIFLDTSRPGQAAVTGEPAGFAVHIIGGGRPAVSHFVPTGNYRPLMHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZAV5</accession>
    <name>A0A1H5ZAV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="12" type="ORF">SAMN04489712_104411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32476">
        <property type="protein sequence ID" value="SEG32476"/>
        <property type="gene ID" value="SAMN04489712_104411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG32476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="13965" checksum="3B58A76B95413087" modified="2017-01-18" version="1">MEARAQARFIRVTPRKARRVVDLIRGLPAAEAQAVLRFAPQAASEPVGKVLASAIANAEHNFKLDTDTLVVSRAWVDEGPTLKRFRPRAQGRAYRINKRTSHITVIVEPRESATAGNGAGRKRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZEF4</accession>
    <name>A0A1H5ZEF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-monoxide dehydrogenase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34444">
        <property type="protein sequence ID" value="SEG34444"/>
        <property type="gene ID" value="SAMN04489712_104499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="17810" checksum="CE8020834D74F497" modified="2017-01-18" version="1">MPRVRIKVDGVTYEDEVEPRLLLVHYLRERLGKVGTPVGCDTTNCGACTVLLDGLSVKSCSVLAVQADGREITTVEGLGPGGELHPMQRAFHTEHALQCGFCTPGMIMASIDLLRENADPSEAEIREGLEGNLCRCTGYQNIVRAVRRAAEEMRQAPEREVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZI03</accession>
    <name>A0A1H5ZI03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35750">
        <property type="protein sequence ID" value="SEG35750"/>
        <property type="gene ID" value="SAMN04489712_104559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG35750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="195" mass="21130" checksum="1ACEB24114ACD0E0" modified="2017-01-18" version="1">MFRPTAARVGAWVWLVFAAFNLADIAWRGRNLASLIAAAVILFLCGLAYVLGLRPRIAADDTALELRNPLRDVRVPWPALRGIEADHALDVRFTVAGGADRTARAWVLQTSPRARAREERRFRKEARHLPPEVAAKAAGRTALGYAAEQLNELAARRRRAPGDGTGTVAWSIPAIAALAVPGVLLVVTVALGFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZZ9</accession>
    <name>A0A1H5ZZZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional non-homologous end joining protein LigD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41554">
        <property type="protein sequence ID" value="SEG41554"/>
        <property type="gene ID" value="SAMN04489712_10585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04863">
        <property type="entry name" value="MtLigD_Pol_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033649">
        <property type="entry name" value="MtLigD_Pol-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG41554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="302" mass="33536" checksum="CDFFD83A7A10CDE3" modified="2017-01-18" version="1">MSKGERVRVQVDGRVLSLSNLDKVLYPKDGFTKGEMIDYYTRITPVLLPHLRDRPVTRKRYPDGMPGQSFIEKNAPAGTPDWVRTVNLPTPGSAKGRASADYVMVDGLPTVVWLANLAAVELHVPQWRVGPRGGVHRPDLMVFDLDPGPPATIVDACQVACALRELLDSDGLTAYPKTSGKKGLHLYVPVRESGRTRDYAEKAALRLEESDPRHVTTRMDKRLRRRKVFIDWTQNDPGKTTVAPYSMRGSDRPAVSAPVTWDEVEACREPADLAFVTDQVLARVEEHGDLMAPLLEEGPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A635</accession>
    <name>A0A1H6A635_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44203">
        <property type="protein sequence ID" value="SEG44203"/>
        <property type="gene ID" value="SAMN04489712_105239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="129" mass="14979" checksum="1535EF3F70065974" modified="2017-01-18" version="1">MDERRAELDLTWDDVAKRAPLSKQGLHTIRFEDRPMRQLTKARIERALEWAPGSVDRILAGGDPEPLKVGRIHYGGLNVPAPPEETVFERLDRLVDEWRQVRREDSKQDQKRAEVLEELLNSWRGRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9H4</accession>
    <name>A0A1H6A9H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombination endonuclease VII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44707">
        <property type="protein sequence ID" value="SEG44707"/>
        <property type="gene ID" value="SAMN04489712_105266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="92" mass="10226" checksum="D2DA98A90C798DE3" modified="2017-01-18" version="1">MPSEGSTTARGYGYNHQQLRKALLAKLKARPGQPCPHCGHPMHPDQALDLDHTDDRTAYRGLAHRSCNTAAGARKLARRRRKAKAAKLTGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AB75</accession>
    <name>A0A1H6AB75_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45993">
        <property type="protein sequence ID" value="SEG45993"/>
        <property type="gene ID" value="SAMN04489712_105336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="331"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG45993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="405" mass="42130" checksum="33633FC9541FDB16" modified="2017-01-18" version="1">MALVSVDEVRAARELLHDVIVETPLLHSRVLSEMLGGPVLLKCENLQRTGSFKARGAYVRIARLTEDERARGVVAASAGNHAQGVALAASLLGCKATVFMPEGAPLPKVAATRSYGAEVLFPGPSVDECLIAAREYADRQGAVLVHPFDHPDVIAGQGTIGLEILEKCPDVRTIVTPVGGGGLAAGIAVAAAGAPHAGGGVPIVGVQAKRAAAFPPSLAAGHPVHIRPGPTMADGIAVGSPGELTYALVSELVDTVVTVTEESISQALLLCLERAKQVVEPAGAAAVAALLEHAHAFEPPVVAVLSGGNIDPLLLSKVLRHGLAGAGRYLVVRCRLADRPGALVILLRELAELGVNVLDVMHERVAARLHMEEAEVLLQLETRGPDHCDEVLGRLRSKGYTLELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ACN7</accession>
    <name>A0A1H6ACN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein, contains von Willebrand factor type A (VWA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46060">
        <property type="protein sequence ID" value="SEG46060"/>
        <property type="gene ID" value="SAMN04489712_105340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="470"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG46060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="659" mass="73442" checksum="DFFE405FA1989581" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADP2</accession>
    <name>A0A1H6ADP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_105387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46853">
        <property type="protein sequence ID" value="SEG46853"/>
        <property type="gene ID" value="SAMN04489712_105387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG46853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="649" mass="68222" checksum="6B42AA70F6F1C67A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AF72</accession>
    <name>A0A1H6AF72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47151">
        <property type="protein sequence ID" value="SEG47151"/>
        <property type="gene ID" value="SAMN04489712_105404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG47151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="34073" checksum="543D0DBA2C218EEC" modified="2017-01-18" version="1">MTGKERREQLLGIGRTLFAERGLDGTSVEEIAAAAGVSKPVVYEHFGGKEGLYAVVVDREFERLLGLVTDALLAGTHYRQKLEKAALALLEYIEESSDGFRILVRDSHGGTGTGSFASLLSEIAGHVEHLLAREFDRHGYDDKHAPMYAQMLVGMVALTGQWWLDVRKPGREEVAAHVVNLAWNGLSGLEPKPTLDPKRRRKERERLRRVREKEAAKQEKAEEKAAAKAEKAQRKARRDEPAKPDQFEQLHEHDQFDEHDRPDEPGPAAGLGEADELDRADEPGTPGPQPAEETEHGLDTPAPGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AIB2</accession>
    <name>A0A1H6AIB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDE superfamily endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48132">
        <property type="protein sequence ID" value="SEG48132"/>
        <property type="gene ID" value="SAMN04489712_105458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="3">
        <location>
            <begin position="53"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG48132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="15512" checksum="2F1CEB39C4A771B3" modified="2017-01-18" version="1">MSMAGVVCFRPGGRPHLFSVLRLHHGRKSEPKGFAWTDYRDLIIATHRHLDAPVVWCRDNLNVHLAPQLATFAADNAAWLRVFQLPSYAPELNPAEGVWPLLKRAMANFAAAKRCGTEAGSHLSDKETDARKGAVRCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJL1</accession>
    <name>A0A1H6AJL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48592">
        <property type="protein sequence ID" value="SEG48592"/>
        <property type="gene ID" value="SAMN04489712_105483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG48592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="470" mass="52493" checksum="7758895A5C71C7A8" modified="2017-01-18" version="1">MSRDEQARLVLTAHPLQRVGTYAVAALARRRRPEDVDAGAFAEVEGVLREDAVRSALVRDTKRDFWLKCSFSVFPNSPMAHPSNGKKDDETIRSAVRRWRTMPDPTGWPDADCVLCGRQAVEFFGKVDVPLAESDIYRNTTPRGHDGMALCWPCVVCFYALPYGCRLTGGPLTALHSWHDAFLGGTTARRVGHNRQSFTLGGSPRDKTVDSEVVALWELRRYGEPIRSGVELLVFTNNNRGQALTIESMEQPLAEWLRRTMRSPQLKRGFKALLGAHWTPRQTAAVGLARNAFREPARILGAAARLLAERGERGVIPDYTADLAELCRSFAIEVMSMNPKDMTEIQATAARVATVLGTQESGGRLKEFYATLKEPARMRHWLMRRGVDWALVGPKDADGPLMTSRAMELLFDPDPDIQAWLNRQMLLVAVLEELHTRGWRPKDGAQVAEELAEEHGAEGLQALEEEVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJX7</accession>
    <name>A0A1H6AJX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="11" type="ORF">SAMN04489712_105477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48464">
        <property type="protein sequence ID" value="SEG48464"/>
        <property type="gene ID" value="SAMN04489712_105477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG48464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9889" checksum="4AE536110209F46B" modified="2017-01-18" version="1">MYVVVVYDTAAERNPKILRTCRQYLHHVQRSVFEGSLSPAQLRRFKAAVESCIDSGYDSVLVYTYPPGATPERQSWGRPQDSPTDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZY3</accession>
    <name>A0A1H6AZY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54181">
        <property type="protein sequence ID" value="SEG54181"/>
        <property type="gene ID" value="SAMN04489712_106141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293185" description="DUF1524 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="107"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG54181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="22187" checksum="F695FEC4F255E941" modified="2017-01-18" version="1">MRRLLSAGALAVVLTIVLAPAASATPPNIPSASTAASRLAALTVRAESNHSSYNRDLFPHWITISGTCNTRETVLKRDGSGVVTDSGCAATSGSWYSPYDGATWRAASDVDIDHMVPLAEAWSSGAYAWTTSQRQSYANDLGGPELWAVTDNVNQAKGDKDPAEWQPPLASFRCTYARAWIQVKWYWNLSVDSAEKSALTAMLNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2D1</accession>
    <name>A0A1H6B2D1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55043">
        <property type="protein sequence ID" value="SEG55043"/>
        <property type="gene ID" value="SAMN04489712_106199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="95"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="31033" checksum="16E9E63B59EBAE79" modified="2017-01-18" version="1">MTNVREPLDPKISMWHFLAFYLRFMREKHGLSLAQCGKIVHAARSTVCNIEAGRLRPHDHQMRLLDLNYGTGILFQMLLWFAQMAHDPNWGRQHYLYEVQANTIKIYNAHAVPRPFQTERYIRAIVEAGSTIDVEAEVAKRIAQQQAILDRETPQFYWILLDESVLACRMEDPEIMKEQLRHLRVTADLPNVILRFVPPSAGPHPGYDGPLQILSLEGRDVAYAGAQNSGRLIEEPVEVRETINNFDRIGAKALPEGATRSLIDQYLEGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B341</accession>
    <name>A0A1H6B341_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55030">
        <property type="protein sequence ID" value="SEG55030"/>
        <property type="gene ID" value="SAMN04489712_106198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="63" mass="6805" checksum="F20B42543F5FD717" modified="2017-01-18" version="1">MIIHWRKSSHSSGVNDAHCVEVGRLPQGVGVRDSKNPAAGHLNLSADQFTALLAQIKRHPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BE64</accession>
    <name>A0A1H6BE64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58950">
        <property type="protein sequence ID" value="SEG58950"/>
        <property type="gene ID" value="SAMN04489712_10735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG58950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="46" mass="4675" checksum="81175A34CA30C621" modified="2017-01-18" version="1">MTAREPLRAHAMPRPRAGGGLDGRGGPGPDRPGPGRPFPSARMAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BFL0</accession>
    <name>A0A1H6BFL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59548">
        <property type="protein sequence ID" value="SEG59548"/>
        <property type="gene ID" value="SAMN04489712_10776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="130" mass="13528" checksum="739D0F2394415A35" modified="2017-01-18" version="1">MKMRIPFIAGAAVGYVLGTKAGRERYEQIVQQSRKLAENPRVQETAGVLRAKSGELAGTAKQKAGDARHKMGGKRHAEHGERAEHGGPQTRTETGGGFAKTSAEATGTGTPTETGTPSGTGAPSSSSRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BGC4</accession>
    <name>A0A1H6BGC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59682">
        <property type="protein sequence ID" value="SEG59682"/>
        <property type="gene ID" value="SAMN04489712_10784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007427">
        <property type="entry name" value="DUF475"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04332">
        <property type="entry name" value="DUF475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG59682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="368" mass="38925" checksum="FA4BF8601E542E81" modified="2017-01-18" version="1">MILRTFGWSFAVTALGLVAALLYGGPAGLALVAVLAVLEISLSFDNAVVNAKVLDRMSPFWQKIFLTIGIAIAVFGMRLVFPLLIVGITAKLNPIEAIDLAFNDHEAYADRMHEAYPMIAAFGGMFLLMLFLDFVFEERADKWLPWLERPLARIGKLDQLSVVVAGGSLAFVAGNFADDPGQVMIAGVLGMVTYILVNGLGELFADGGDLGEEGEGKGGTGPNGLVLATGKAGFFLFLYLEVLDASFSFDGVIGAFAISTDPVVIMLGLGIGAMYIRSLTVFLVRKGTLHEYVYLEHGAHWAIGALAACMLISIGSHVPEWITGGLGAGLIIAAFLSSVLRNRREGDGEPGDEAGEGKELHPTGVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BIG5</accession>
    <name>A0A1H6BIG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucoamylase (Glucan-1,4-alpha-glucosidase), GH15 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60157">
        <property type="protein sequence ID" value="SEG60157"/>
        <property type="gene ID" value="SAMN04489712_107113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="258"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG60157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="635" mass="71580" checksum="FBAC52DDD2B8B108" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJ02</accession>
    <name>A0A1H6BJ02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_107153</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60741">
        <property type="protein sequence ID" value="SEG60741"/>
        <property type="gene ID" value="SAMN04489712_107153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="22"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG60741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="402" mass="43538" checksum="3AEF6C5F8CF8A056" modified="2017-01-18" version="1">MPAILPDGDPVPADGALPGSALDGLGTRPLAFYVHVPFCVTRCGYCDFNTYTATELGPGASRESYADTAIAEVRLARRVLGDADLPVETVFFGGGTPTLLAPDDLGRILAAIDAEFGLAAGAEVTTEANPESVDEGYLGKLRAAGFNRISYGMQSTREHVLAVLDRTHTPGRVPQVARWAREAGFEHVNLDLIYGTPGESDDDWRASLRAALKAEPDHVSAYALIVEEGTRLAGRVRRGELAAPDDDAMADRYLMTEEMLSAHGLRWYEISNWASGPQAACRHNLLYWTGADWWGVGPGAHSHVGGTRWWNVKHPAAYAARLAEGRSPAHAREVLDAEDRRIERIMLELRLAQGCPAELLDDAAVRRAVAEGLIEPAPYERGRAVLTLRGRLLADAVVRDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKF5</accession>
    <name>A0A1H6BKF5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rny</name>
        <name evidence="9" type="ORF">SAMN04489712_107193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61201">
        <property type="protein sequence ID" value="SEG61201"/>
        <property type="gene ID" value="SAMN04489712_107193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293863" description="Ribonuclease Y" evidence="7">
        <location>
            <begin position="32"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="8">
        <location>
            <begin position="341"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG61201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="526" mass="58847" checksum="CFD46B7EE7A222E2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKM3</accession>
    <name>A0A1H6BKM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61258">
        <property type="protein sequence ID" value="SEG61258"/>
        <property type="gene ID" value="SAMN04489712_107198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021408">
        <property type="entry name" value="DUF3046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11248">
        <property type="entry name" value="DUF3046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG61258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7662" checksum="C93561B6B1CC1E77" modified="2017-01-18" version="1">MAVVRLSVFWDRMKQHFGETYAESLAKDYVLAELDGRTIDQALADGESAKRVWEAVCATFDVPQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKR6</accession>
    <name>A0A1H6BKR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_107179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61055">
        <property type="protein sequence ID" value="SEG61055"/>
        <property type="gene ID" value="SAMN04489712_107179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG61055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="294" mass="31155" checksum="B2FBB1DFDD65822D" modified="2017-01-18" version="1">MTTTFREPPVGMPSRGADLARRVLADRRAVLGLALLGALFLLAFAGPHLAKWHWTDTDFAAMREPPSAGHWFGTTQSGRDVYALTLRGMQKSLLIGICAAVLSTGLAALVGTVAGYAGGWADRALMWGTDLLLVLPAFLVVAVLSPAFRAAWPLLVLLLAAFMWMVTARMVRQMTISLKRREFVLAARYLGVGPARIVVRHILPHLGSLLIIDGTLNVSVAIIAESGLSYFGFGVQPPDSSLGTLIAEGTGAATTFPWLFGFAAGLLVLIVLAVNLVGDGLRDALDPAAKGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLK8</accession>
    <name>A0A1H6BLK8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="12" type="ORF">SAMN04489712_107228</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8 10"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61611">
        <property type="protein sequence ID" value="SEG61611"/>
        <property type="gene ID" value="SAMN04489712_107228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="53"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG61611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="227" mass="24850" checksum="DBA37C50551F82F0" modified="2017-01-18" version="1">MSLDLMELLPADWRERLDPLLDPLATAALGAFVEAEYERHTVYPAREDLFNAFRRCRYDDARVLILGQDPYHGPGQAHGLSFSVREGVRLPPSLRNIYKELAADLEVPVAKSGDLTPWAAQGVLLLNAVLTVRAGEAGSHAGKGWEEFTDAAITALNAKDERVVFVLWGAYARKKARLVTNPAHVVIESAHPSPLSAKKFFGTRPFSAVNKALTDAGLPEIDWALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BW56</accession>
    <name>A0A1H6BW56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64938">
        <property type="protein sequence ID" value="SEG64938"/>
        <property type="gene ID" value="SAMN04489712_10865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="57"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="29549" checksum="D78295F24D99736D" modified="2017-01-18" version="1">MSSTPDEPTDTADNPVYDNPWAYDLACAFRDVRAEVDALLGWYARSGPSRRGLPGSVLELAAGPAEHAREFARRGIPATALDLSPAMCAYAEERAKADGVALEVVRADMARFELGRGFDLIVTMLDSTAHLMTLDAFVAHLDRVAGHLTAGGCYVLEMSHPADRLTDEPSTGTVWTVERDGVRADVRWGEPGDRLDPITQVVREHVTIAVAREGGSEVIRGVVPYRFWTATELTAAVRLSGALRVVAQYGDFTGIGPGDPDAWRLITVFRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXV2</accession>
    <name>A0A1H6BXV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65483">
        <property type="protein sequence ID" value="SEG65483"/>
        <property type="gene ID" value="SAMN04489712_108109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045745">
        <property type="entry name" value="HTH_58_Actinobacteria-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19575">
        <property type="entry name" value="HTH_58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_58" evidence="1">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="70" mass="7506" checksum="2F5A477D50AE25F5" modified="2017-01-18" version="1">MAETLKKGTRVTGAERDKLAAELKKRYDSGESIRALAAATGRSYGFIHRILTESGVNLRGRGGATRGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BY00</accession>
    <name>A0A1H6BY00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65579">
        <property type="protein sequence ID" value="SEG65579"/>
        <property type="gene ID" value="SAMN04489712_108117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04623">
        <property type="entry name" value="CBS_pair_bac_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044725">
        <property type="entry name" value="CBSX3_CBS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG65579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="15451" checksum="9C3A854A43D940B6" modified="2017-01-18" version="1">MRIRDILRNKGHEVATVRPDATVRELLATLAELNIGAVVVSPDGVGIAGIVSERDVVRRLHERGADLLGAPVHDIMTAEVRTCGPDADVAELRTTMTEHRIRHVPVVDEGRMVGLVSIGDVVKSAIDELETEREHLVGYLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BY24</accession>
    <name>A0A1H6BY24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65357">
        <property type="protein sequence ID" value="SEG65357"/>
        <property type="gene ID" value="SAMN04489712_10898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="206"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG65357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="412" mass="44158" checksum="339C44AD379EEE6C" modified="2017-01-18" version="1">MYDPGPGLRAGEERGLGEDVRVRFTTRQDALLAVAALAGGLLLLSAHGYSAWEPDDPWPGTGWRVLPLLGVCAAMLFRRTSPMAGLAVATPAMVADIVMSPSLGTMLVYTDALYASSLYGPRRMAERLLAVTVAVTVLLAGGVGLWASAWEATVIIGGVAGMTWVGPVLTAMVVREHRNRAELERQRAEQLARLAELDRRNAVADERARMARELHDVVANHLSAVALHSSAVLRLPDLDREGVRQAMSVIRENSVQGLAEMRRMIGLLREERDGTGDPPAAPRLADLERLAERAARPDLSVGVKVTGTARELPAAVELAAYRIVQESLTNVLKHAGPGRAEVLVEHRPDRLCVTVESPLGAERTELPGAGSGLIGMRERASILRGTFTAGPEDGCWRVRAELPTTTPDGGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYJ3</accession>
    <name>A0A1H6BYJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoheptose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65784">
        <property type="protein sequence ID" value="SEG65784"/>
        <property type="gene ID" value="SAMN04489712_108135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="30"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="20412" checksum="C387D66A31CDB0C7" modified="2017-01-18" version="1">MTEAHLTRLETALRRLRRRTALVEEWGRLLADVLGSGGRLLACGNGGSAAQAQHLTAELVGRFDGERRALSAIPLHGDTSALTAIGNDYGADEVFARQVRAHGRSGDILICLSTSGTSRNVIAAARAATEQGMRTWALTGPAPNPLAGMCDAALAVDAPVTATVQEIHLAVVHMLCAVVDRVIREDDRRAVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZT8</accession>
    <name>A0A1H6BZT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6457 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66198">
        <property type="protein sequence ID" value="SEG66198"/>
        <property type="gene ID" value="SAMN04489712_108172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045598">
        <property type="entry name" value="DUF6457"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20058">
        <property type="entry name" value="DUF6457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6457" evidence="1">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="78" mass="8484" checksum="8C36E2168519775F" modified="2017-01-18" version="1">MLEEWIEAVCLELGLERDQIDRDLVLDLARDVAHGVARPAAPLTAYLLGLAVGRGDAARDAAARITDLAEGWAERSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C0A1</accession>
    <name>A0A1H6C0A1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66399">
        <property type="protein sequence ID" value="SEG66399"/>
        <property type="gene ID" value="SAMN04489712_108189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022492">
        <property type="entry name" value="Phosphomutase_MSMEG4193_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03848">
        <property type="entry name" value="MSMEG_4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="234" mass="24437" checksum="52AD8F6E25C84F57" modified="2017-01-18" version="1">MTTLLLVRHGLTELTGPVLAGWTPGLSLDERGRAQARALGDRLASVPLAAVVSSPLDRCLQTAGAIVAASGRRDGPGEVLRDERFGEVRYGDWTGRPLKELAEEPLWRVVQAHPSAAVFPGAQGEAMAAAQHRAVTAVRDWNARIAAQAGPDAVYLVCSHGDIIKAIVADALGLHLDQFQRIQADPASLTVIRYTELRPFLVRLNDTGGGVDGLLPPPGTPAGGEGDAPVGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1G3</accession>
    <name>A0A1H6C1G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent RNA helicase HelY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66840">
        <property type="protein sequence ID" value="SEG66840"/>
        <property type="gene ID" value="SAMN04489712_108229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="rRNA_proc-arch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="rRNA_proc-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="45"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="290"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG66840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="919" mass="101012" checksum="20D25851358A29F4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7C4</accession>
    <name>A0A1H6C7C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68808">
        <property type="protein sequence ID" value="SEG68808"/>
        <property type="gene ID" value="SAMN04489712_10921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG68808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="93" mass="9906" checksum="EEC7960FDB88AA24" modified="2017-01-18" version="1">MTKTGTLARTGTVAKKASATARTGTVARKAGAFARTGAVARRTGAGKTGAMKGGGAVRRRRRMVPFIAAGAVLAMMMWREVPAMRRYYKISRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C920</accession>
    <name>A0A1H6C920_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69474">
        <property type="protein sequence ID" value="SEG69474"/>
        <property type="gene ID" value="SAMN04489712_10987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG69474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="216" mass="23241" checksum="37325034647E1B8E" modified="2017-01-18" version="1">MIRVLIADDQEMVREGFSVLLNAQPDIEVVGEAADGGEAVAKAAELRPDVVLMDVRMPVMDGLEATRRLAGSTGVLVLTTFDMDEYVYAALRAGASGFLLKNSSARALADAVRVVAAGDALLSPVVTRRLIAEFARLGGPRAPSRRRLEGLTERETEVLVLIAHGMSNAEIATRLVVVEQTVKTHVSNILAKLGLRDRTQAAIYAYETGLVRPAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCG4</accession>
    <name>A0A1H6CCG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70588">
        <property type="protein sequence ID" value="SEG70588"/>
        <property type="gene ID" value="SAMN04489712_109182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="2">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG70588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="154" mass="16080" checksum="85234B0D9598279B" modified="2017-01-18" version="1">MDHAEHTHGGSGWRTAAQATLHCLTGCAIGEVLGMVIGTALGLHGVATVALAVALAFFFGYALTMRGMLRADLPFRRALKVALAADTVSIAVMELVDNGVMLGVPGAMEAGLSSLLFWTSLAFSLAVAFAATLPVNRWMIARGLGHAAAHQYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJJ0</accession>
    <name>A0A1H6CJJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72576">
        <property type="protein sequence ID" value="SEG72576"/>
        <property type="gene ID" value="SAMN04489712_11015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG72576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="15070" checksum="5C604FF600D94E93" modified="2017-01-18" version="1">MWLVVAVALLLVGWGALVRRRVGLRVWRPLLRRVPDSALAAGLFAVGLQLAAMIAYGCAVALGLSLGDATGMSWPAPTVIGLAGLLQAPIVMMAMPDRGAGPYAEVRAMLEDAGATGAQGRAAAWAGGPAAFLAMGLIVGSLFAAFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CR31</accession>
    <name>A0A1H6CR31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75434">
        <property type="protein sequence ID" value="SEG75434"/>
        <property type="gene ID" value="SAMN04489712_11137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="55" mass="5984" checksum="D3300A71C067BA95" modified="2017-01-18" version="1">MPEPNEAGSSPELAHMDEVDVHPDVHRATEPDEEQVLRELYGAPDADGIFRGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRF7</accession>
    <name>A0A1H6CRF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75554">
        <property type="protein sequence ID" value="SEG75554"/>
        <property type="gene ID" value="SAMN04489712_11155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="110" mass="12349" checksum="CC955357B8C01801" modified="2017-01-18" version="1">MEFLSAAQQVELCLDRLSMGEQLEESEKWEHLHTLWLAKKVPELVCTPAVAQAAHDYTLALHALLRGQATEAGAPPKRELRFAFMEAARQELGMASEPLRRDLPARELGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSU5</accession>
    <name>A0A1H6CSU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76090">
        <property type="protein sequence ID" value="SEG76090"/>
        <property type="gene ID" value="SAMN04489712_111121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="161" mass="17148" checksum="2CD4CFA5BD8132CF" modified="2017-01-18" version="1">MPHCPPRPGRRSPEDHPNGRGPESPDATALRNACAESVAAALTDTADIGGFFTITVGGPDRGRHPVAADYARGVPDLITANTERYGTPEARIGASIMQLGHAARLWSPVLACTIVHGLVPDLTDLHRAEDGLALRLPAPGGRCRCRRDARPAWWRPEGADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT97</accession>
    <name>A0A1H6CT97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron complex transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76164">
        <property type="protein sequence ID" value="SEG76164"/>
        <property type="gene ID" value="SAMN04489712_111131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295183" evidence="1">
        <location>
            <begin position="36"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="88"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="349" mass="34781" checksum="9DD7CAE9D0ED9A1C" modified="2017-01-18" version="1">MSAALRIRVRGARTATLAVLAALGLGGCAVGGASATGGTDPAASCGPSVVRTGQAIEPVEPAPTPKLPVTVESADGRPVTVRSADRILAVNMYGSIAEIVFSLGLGDRVVGRDASTTFEAAADLPLVTTNGHDLSAEAVLRLDPTVVLLDAGIGPAGAVDQLRDSGIPVVLIGDQQTLPAIGEHITEVAAALGVPEAGRALKEQVGEQIDAARAESAAGAEPLRIAFLYLRGTAGVYLIGGRGAGSDALIEAIGATDAGAAAGLAGFRPLTSEGMINAAPDVILVLTGGLESVGGVDGLVRLPGVGQTPAGRNRRIVSADDGALLTFGPRTGKTIRALAEAVHRPCGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CX77</accession>
    <name>A0A1H6CX77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, TraR/DksA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_111249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77105">
        <property type="protein sequence ID" value="SEG77105"/>
        <property type="gene ID" value="SAMN04489712_111249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG77105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="11813" checksum="70389F9C5E543A77" modified="2017-01-18" version="1">MATDAPGRLSSVQLQALRERIEADLSWRAIRLDQLVTRLREDPLSGTERPGLLAEVIAAETHLAELRRALERIGEGDFGRCERCGDPIGYALLKLRPLTSRCATCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D131</accession>
    <name>A0A1H6D131_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Raffinose/stachyose/melibiose transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78738">
        <property type="protein sequence ID" value="SEG78738"/>
        <property type="gene ID" value="SAMN04489712_112119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295406" evidence="1">
        <location>
            <begin position="29"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="421" mass="44674" checksum="8C95D0DB593423D3" modified="2017-01-18" version="1">MSRGSRILACGALLVPLLAAGCANEARDADTLEISTISGGPNDPIDTVVREFRAANPGITVTVKKVPFDQHLQGIRRRLSTGRPPDVVTTLPGYGESSSSASLADKGLLLDLSASPWSKEILEADRRITGDGTRTFVYPVSSQAVGTFYDPKVLAREGLSVPTTFSEVLTLCRTVARKGKVAFAMTGQEGAGLTIFVGLALAASDVFADDPRFGERRLAGQATFAGTAGWARSMEHFQQMKDAGCFDKGAAGSSREAAAQAFAKGEALMAVGTTVTLQLFQAGDANLKLKMFPFPGSDDPAKVRIPIGPAVGLVVPKKAGNPGLAKKFLDFYAAGRERYARLDASVPAIPVRTNKPDVPDYAEALRPYLQAGKTAPIMDQHWPNPEVHTQYASGLTEILLGKKDPGQTLKAMDAAWTERAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1Z0</accession>
    <name>A0A1H6D1Z0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79008">
        <property type="protein sequence ID" value="SEG79008"/>
        <property type="gene ID" value="SAMN04489712_112153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="188" mass="20940" checksum="E80A3C6CA2FB4A16" modified="2017-01-18" version="1">MTDQVTFRRLDAAEARRHRDLVADIHRDAYADSIATGDAFASDEAFMTRFDAYTGRGGFDLVFAYADDTTVGQTWGWALAPDTAWWSGLVSEPESGFTVEDGTRTFALSELMVRRAWTGQGIAHALHDALLSARTEQRATLLVRPDNATAYNAYTRWGWRRVSQLRPGWPGAPLMDVLVLELPLESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5K1</accession>
    <name>A0A1H6D5K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_113124</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80657">
        <property type="protein sequence ID" value="SEG80657"/>
        <property type="gene ID" value="SAMN04489712_113124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="164"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="302"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG80657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="413" mass="46241" checksum="FE1758AA48FCED8E" modified="2017-01-18" version="1">MLVGRKYRLSLTAEQAEMAEEFGNICRSVWNTALEQRREYRRRGAWMNYVPQAAELADAKREHEWLRAAPSHVLQQTLKDLDKACRTHGTFKVGWRSKTRWNPSFRFPAGNLITVERLNRKRGRAKLPKLGWVVFRWSRHPGGEVRSATVSRKAGHWYISFLVEDGVLPPGHHAGTPVGIDRGVVVAATTSTGKFYDREFATTGEKTRYRRLQQRLARTRKGSANRRKTVASMSRIMVRVTDRRADFTAWTANRLTARHSVVVLEDLRTKNMTASAKGTEAEPGRNVRQKAGLNRAILDKGWHRMELAIRNAARSTGTQVVLVDPAYTSQTCNRCGHVDAKNRESQAVFVCTACGHRGHADVNAAKNILSAAGHAVPACGDLGVTRSVKQELPGPREAVPVRLAFELVGIPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D600</accession>
    <name>A0A1H6D600_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80691">
        <property type="protein sequence ID" value="SEG80691"/>
        <property type="gene ID" value="SAMN04489712_113132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="14741" checksum="9C5AADF875B19B1A" modified="2017-01-18" version="1">MLLMSPPAAEAVPLYWRREFPGGAMQARAVRRFVACLLDGCPFLDDVLLATDELVVNAVRHTKSGQAGGSFTVEVLCGDGGIAVSVADQGGPDEPVARDADPLAESGRGLRTVSLTAESWGWHGNSAGRTVTAVFAGKWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9E4</accession>
    <name>A0A1H6D9E4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetaldehyde dehydrogenase [acetylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:23288"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the acetaldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81285">
        <property type="protein sequence ID" value="SEG81285"/>
        <property type="gene ID" value="SAMN04489712_11416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01657">
        <property type="entry name" value="Ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003361">
        <property type="entry name" value="Acetaldehyde_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015426">
        <property type="entry name" value="Acetylaldehyde_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09290">
        <property type="entry name" value="AcetDehyd-dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015689">
        <property type="entry name" value="Actaldh_dh_actl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03215">
        <property type="entry name" value="ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="4">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="158"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG81285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="30784" checksum="350598D09241CF97" modified="2017-01-18" version="1">MPAKVPAAIVGSGNIGTDLLYKLRRSELIDPRFMIGIDPDSEGLRRAKDLGVEVSAEGADWLLGRSDRPPLLFEATSAKVHAAAAPRYAAAGITAIDLTPASVGPWVVPAVNLDEHLQAPNLNMVSCAGQATIPLLYAIDQVADVSYGEIVATIASASAGPGTRWNLSEFSEKTGQALTAVAGVDEAKAFSLINPAEPPMVMRDTVYAKVRRSDADRIEHAVRDMVAKVRRYVPGYRLRLVEVDGDLVTVMVQVEGAGDFLPAYAGNLDIITAAAVAVAERIAEQTLGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCX3</accession>
    <name>A0A1H6DCX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_115135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83064">
        <property type="protein sequence ID" value="SEG83064"/>
        <property type="gene ID" value="SAMN04489712_115135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="18037" checksum="9FC17E46EE874E0E" modified="2017-01-18" version="1">MKDALTIHRSLLEREIVHEIVRLPRPITQADELPRMLDLPPERCLATRMYGCLDAARGERFLAALIVPAGSHPDLEPVRRAVGARLIRPARPDLVNSIADYCADLVCPLLLPDTVPVLIEQDTMDLLSPDVVVYTATGEPLTALGLRMADLYALSGAKPVGLCPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFC7</accession>
    <name>A0A1H6DFC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase (Acceptor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_116105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83934">
        <property type="protein sequence ID" value="SEG83934"/>
        <property type="gene ID" value="SAMN04489712_116105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="26"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG83934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="498" mass="53208" checksum="C63D8677AF15E7BF" modified="2017-01-18" version="1">MPALPRTDTLTFLDGRPKRLLIGGRWVEAASGRTFPSVNPSNGEVIAELAEAGAADADRAVAAARAALDGPWRRMTPRQRQTILLRCADAVDAHYDELRLLESVDMGAPIGRSRSGRHPAWEAEVLRYFAGWATKLHGETIPNSIPGSVFSYTLREPVGVVAAIVPWNRPINNAVWKIAPVLATGCTMVLKPAEEAGLVAVRLGELLAEAGVPDGVVNVLTGFGEPAGAALAEHPGVDKVAFTGSTEVGRQIVRASAGNLKRLSLELGGKSPDVVFADADLTKAVPGAAMGVFAFSGQVCCAGTRIYVERPVYEEFVDGVSKFAAGLRVGDSLDPNTKIGPLVSAEQLRRVTGYLELGPQEGARTTAGGRRLTDDGLAGGYFVAPTVFADVRDTMRIAREEIFGPVACVMPFDTLEEVVARSNDTSYGLAGGVWTRDVGRAHRMARELRAGTVWVNSMLLMDPAVPFGGYKMSGWGREMGRHALDEYLDVKSVWIDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHD1</accession>
    <name>A0A1H6DHD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_116140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84085">
        <property type="protein sequence ID" value="SEG84085"/>
        <property type="gene ID" value="SAMN04489712_116140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG84085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="20765" checksum="34A8A83C239DB0BF" modified="2017-01-18" version="1">MTAPAAVWVVAGPPGSGKTTVADALLARLRPVPALLDKDTMYGPFVAATLAAHGRDPGEREGPWYDEHIKRHEYAGMAAATREIRSHGCPVLLSGPFTGQIHDTGRWHAWVGELGGPPVHLVWIRTDPETLHHRLTARALPRDAGKLAAFDAFLARMRPGVPPPVPHLEVDNRLSASPALADRLDRLVAATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHJ5</accession>
    <name>A0A1H6DHJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84798">
        <property type="protein sequence ID" value="SEG84798"/>
        <property type="gene ID" value="SAMN04489712_11770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295927" evidence="3">
        <location>
            <begin position="27"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="293"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG84798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="532" mass="55205" checksum="374BDD80647AE612" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DK15</accession>
    <name>A0A1H6DK15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85441">
        <property type="protein sequence ID" value="SEG85441"/>
        <property type="gene ID" value="SAMN04489712_1184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="92" mass="9600" checksum="1AB3A0CCB0B238BF" modified="2017-01-18" version="1">MSTVSVRIPTILRTYTGGESEVKADGATLGEVIADLDANYSGIAARILDDDGRLRRFVNVYVGDEDVRFADGLDTATPAGTQISIIPAVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQY1</accession>
    <name>A0A1H6DQY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87096">
        <property type="protein sequence ID" value="SEG87096"/>
        <property type="gene ID" value="SAMN04489712_12067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="65" mass="7205" checksum="989FE3AB00698D89" modified="2017-01-18" version="1">MAKALLGHVGGPDPRMVAEMRRLQRRVRDLEAELVRLQAENDALAAEAREDVLSLGVKDREPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DR86</accession>
    <name>A0A1H6DR86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87125">
        <property type="protein sequence ID" value="SEG87125"/>
        <property type="gene ID" value="SAMN04489712_12072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="21434" checksum="C976F1C3AFCB4DF2" modified="2017-01-18" version="1">MSHESRKALDRLDPRAPLVLDTRALDRRPGSMRELTRTVPAPADLGVEMVGVPEGTDIELDLRLESVMEGVLVTGTARMPLTGECARCLDPLEDTFEAEFQELFVYPDTRSGGEAEEDERRIEGDLIDLEPVLRDTVVLALPLSPLCRDDCPGLCPDCGVRLADAGPDHHHEVADPRWAALRGLTDQREEKQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRA7</accession>
    <name>A0A1H6DRA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aromatic-ring-opening dioxygenase LigAB, LigA subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87809">
        <property type="protein sequence ID" value="SEG87809"/>
        <property type="gene ID" value="SAMN04489712_1216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036622">
        <property type="entry name" value="LigA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011986">
        <property type="entry name" value="Xdiol_dOase_LigA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07746">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48076">
        <property type="entry name" value="SSF48076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="85" mass="9290" checksum="CDDF934CD6D3EA81" modified="2017-01-18" version="1">MSVVGLNRLARELEHTPGLLEAFLATPEPVLADYPLTPEERLAVVRRDAAWLLERGMNPVALRNLMVVLGVAHQDMYTVPAADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRQ7</accession>
    <name>A0A1H6DRQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87991">
        <property type="protein sequence ID" value="SEG87991"/>
        <property type="gene ID" value="SAMN04489712_12153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="175" mass="18368" checksum="C199CF5D467E3913" modified="2017-01-18" version="1">MAKLLYSATMSLDGYIAGPGGDMSWLTEHLGTPNPTAARLVTRVGAVLAGNVTFGGDDPNKGTDKEGAFGGQYHGPVFVLTHRPPAEPVAGVTFVGDLQTAVAKAKAAAGDRYVNLLGANVARQCVEAGLLDEVLVFIAPVLLGDGVRLFDSPGGRRVRLEPLADESAHWYRVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRZ0</accession>
    <name>A0A1H6DRZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl coenzyme A synthetase (ADP forming), alpha domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88071">
        <property type="protein sequence ID" value="SEG88071"/>
        <property type="gene ID" value="SAMN04489712_12169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="890" mass="92115" checksum="DAA8B84E10BF16A8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT90</accession>
    <name>A0A1H6DT90_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87973">
        <property type="protein sequence ID" value="SEG87973"/>
        <property type="gene ID" value="SAMN04489712_12148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="192"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG87973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="714" mass="78284" checksum="C3866A1CA45F0A2E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTP4</accession>
    <name>A0A1H6DTP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87965">
        <property type="protein sequence ID" value="SEG87965"/>
        <property type="gene ID" value="SAMN04489712_12146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="807" mass="87231" checksum="46E7567763C988BF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYE2</accession>
    <name>A0A1H6DYE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aromatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90352">
        <property type="protein sequence ID" value="SEG90352"/>
        <property type="gene ID" value="SAMN04489712_12611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="36041" checksum="8BE1AA7A0A125039" modified="2017-01-18" version="1">MSQKTTGDETTGREVEHTITVRASAEQVYRLLAEVENWPRLFPPSVHVEYLERDGTDERIRIWATANGEAKNWTSRRKLDPENLRIDFWQEVSAPPVAEMTGAWLIEPAGSAETRLRLLHWYRAIDDDPEGLAWIDQAVDRNSQEELPALKSALEEASADDGLTLSFIDSVEVDGSVKDLYDFVNEAGRWRERLPHVAAVRLTEDTPGLQVLRMDTLTKDGSSHTTESVRVCFPHHRIVYKQTTLPALMSLHTGYWEFEETGDGTARASSQHTVVINAARIPEILGPDAGVPEARAFIREALGGNSRATLELAKKYAEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYI7</accession>
    <name>A0A1H6DYI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein PhnB, glyoxalase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90412">
        <property type="protein sequence ID" value="SEG90412"/>
        <property type="gene ID" value="SAMN04489712_12629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="15518" checksum="030F285E14DCA9B8" modified="2017-01-18" version="1">MRLSSFYPVICTARLKESWDFYTGLLGFETTFEVDWYVSLRRPGPPTYELALLDHTHPTLPAPYRAPVAGLLLNFEVEDVDAEWDRLVTRGGLNAELAIRSEDFGQRHFIVADPNGVLIDVITPIAPSQEYATQYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ14</accession>
    <name>A0A1H6DZ14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90006">
        <property type="protein sequence ID" value="SEG90006"/>
        <property type="gene ID" value="SAMN04489712_12511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="34001" checksum="C0CC65AB7285455C" modified="2017-01-18" version="1">MDVDTRLLRYFAVVAEEGNLTRAAERLFISQPALTKQIKQLETLLDVRLFTRSRAGMTLTEPGRVLAERVPGLLADWERILRETRNAAERVLRIGYLASAANETTQRIIAEFTRRRPDWRAQMRQATWSDPTAGLATADVDVALLRLPFPGQETLRTRALFTEPRCVALPTAHPLAACEVIPFSDLWNEPFVAAPAETGHWRDFWLAADERDGQPVRIGAVVDQPDDWLSAIANGYGIALAPESAARYYARPGITYRPVTGISPSEVGVAWTPADDTDLLVQDFVRCCLACRPPRHDENASRPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E275</accession>
    <name>A0A1H6E275_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91491">
        <property type="protein sequence ID" value="SEG91491"/>
        <property type="gene ID" value="SAMN04489712_12934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296439" evidence="1">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="16028" checksum="DDB1E5B8BCB85C31" modified="2017-01-18" version="1">MMKRLAVAGIASATLGGVLMMGTAAMASPAADANVSVTADWRKHGKDHHDFWDGWDDWDGRKHHAHKHHHHKHHAHKHRHHHHKHHKHHDFWDGWDDWDAHKHHHHKHHAHKHHDFWDGWDGRKHHHKDGHLYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E283</accession>
    <name>A0A1H6E283_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91501">
        <property type="protein sequence ID" value="SEG91501"/>
        <property type="gene ID" value="SAMN04489712_12938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG91501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="30489" checksum="EF014D541F34486C" modified="2017-01-18" version="1">MTTFAELLLNGISMGAVYALIALGFVIIFKASEVVNFAHASLLLAGGFLVAELHPSIGFWPALLAGVAGAALLGCLVEFLVIRRSKAASHSVLAIVTIGVDIILVTELTRQIGTDVMAMGDPWRDKVLHLGPVSIAQTRVVALLIAGVLITAFLLAFKYTGWGVAMRASAEDGETAALMGVRLGRVSLGAWAVAGALAAVAALFLAVFPTPGLDRTTGVIALKAFPAAILGGLDSTTGALAGGLIVGVTEALMTGYQSEMAFLGRGIGDVAPYLVMIIILLVRPAGLLGTRELTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2K8</accession>
    <name>A0A1H6E2K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91948">
        <property type="protein sequence ID" value="SEG91948"/>
        <property type="gene ID" value="SAMN04489712_13139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="23755" checksum="CD46459135FB4E86" modified="2017-01-18" version="1">MRLDNAFHVPVPVREAWDILLDVPRIAPCLPGTVLDGQDGDAYTGRVKIKIGSITASYTGQATVTVTDEAAHTARITASGKEQRGAGRASAQVEMRLVPTDDGTRVEVTTELSITGKAAQFGRGILADVSARLIDQFAANLATEIVAPPAPPEPPAGEPPVAAVPAEPSPPAAAPAPEPVRAAPRPAEPEPFDVLGAVMAGRTRTYAQTAAALLLALVIGLLLGRATRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3L6</accession>
    <name>A0A1H6E3L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched-chain amino acid transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91654">
        <property type="protein sequence ID" value="SEG91654"/>
        <property type="gene ID" value="SAMN04489712_13010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296492" evidence="1">
        <location>
            <begin position="30"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="47"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="416" mass="42315" checksum="72833C7C749AB752" modified="2017-01-18" version="1">MNLGMHKGTTLLRVLLSGGMGLLLTAAAACSGGSDQPSDDPALTGAPIKVGLFNPDKGAVAVPAVKSGMDAGVNYIAKELKGIGGRPVVVEACSVDGTPESTIGCANKFVQNGVVAAFDGFNLSSSAGIAILEAAEIPLIGQIPFDQTTGSAASGRVYFGAPQASFLVGALQGFKAEGKTSATLTLVDTPASHKTVDTQLKPLAGAIGIKANGLYFSPTNPNFSALAATIASTKPDVAGLIASPNASVCTQLIKNLRSVGYSGDIFVAACTGFIKSDPASAPGATLYSSVWLPGTERYAPKAAVDNLKAATEYISKTSGPADFYAYAQFATVVDFAKALAPSPDDLTGKTVLSTLKALKNFPTFLGSPITCGKKTTPNCTTQMLLFSVQKDLSLKPVTGNWITPAPAIMANIPGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3U7</accession>
    <name>A0A1H6E3U7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_13315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92320">
        <property type="protein sequence ID" value="SEG92320"/>
        <property type="gene ID" value="SAMN04489712_13315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03914">
        <property type="entry name" value="UDG_fam_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="43"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG92320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="228" mass="24000" checksum="9B36E03984E63CE3" modified="2017-01-18" version="1">MSAESSHDAGPYVPEHADLAALRRAAAGCRGCPLYADATQTVFGEGEPSAQVVLVGEGPGDQEDRTGRPFVGPAGRLLDQALEEAGIRREDAYVTNAVKHFKFARTAGGGRRRPQPPSAAEVTACRPWLLAELRLIEPEVVVALGAVAGRALLGSAFRVTQYRGRLLTCPPPETLGTRQAARIAEEGGETAGHIVATIHPSAVLRSDDREAMYAGMVADLRVAAQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5S9</accession>
    <name>A0A1H6E5S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron (Metal) dependent repressor, DtxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_13314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92316">
        <property type="protein sequence ID" value="SEG92316"/>
        <property type="gene ID" value="SAMN04489712_13314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG92316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="25749" checksum="0D5A3AF770929211" modified="2017-01-18" version="1">MTSHGLIDTTEMYLRTVFELEEEGIIPLRARIAERLSQSGPTVSQTVARMERDGLLRVEGDRHLELTATGRGLATRVMRKHRLAECLLVNVIGLPWEDVHIEACRWEHVMSEEVERRLVALLGNPTHCPHGNPIPGLDELGVSEDGEESGPLDVMTDVATPAGTPAVVRRISEQVQSDSDLMLILKRLGIQPGREVMLATSEDGVRVSCDDEPEGATELPRRLAEHVFVTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E781</accession>
    <name>A0A1H6E781_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Subtilisin inhibitor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_13716</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93113">
        <property type="protein sequence ID" value="SEG93113"/>
        <property type="gene ID" value="SAMN04489712_13716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000691">
        <property type="entry name" value="Prot_inh_I16_SSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00294">
        <property type="entry name" value="SSBTLNINHBTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296606" evidence="9">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="10">
        <location>
            <begin position="41"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG93113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="14808" checksum="3687177195C4E383" modified="2017-01-18" version="1">MPHLAATTLTGAALVALLPAGIVLADTPSRYDRPAAGTHGTHLKLTVTYPGAPVSSARTVTLRCDPAGRDHPHAAAACADLDRSHGRFLHDPRQTICTMEYRPVTAKATGRWQGRAVSFTKSFPNACVMDARTGAVFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7V9</accession>
    <name>A0A1H6E7V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_13619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92935">
        <property type="protein sequence ID" value="SEG92935"/>
        <property type="gene ID" value="SAMN04489712_13619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="133"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="243"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG92935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="398" mass="43248" checksum="E23D6433ECB90232" modified="2017-01-18" version="1">MTQNPAPDANTAADETLTDEELRAAVRELAERFDDAYWAEVDQETRFPWEFYNAFAEAGWLGIAIPREYGGAGMGISAAASMMYEIAASGAGMNGCSPFHLTIFGLNLVARHGGDRLCRELLPAAATGDLHVCFAITEPDAGSDTSRIRTFARRDGSDYVINGRKVWITKAAQSQKAVLLARTGEPREGGRPTDGLSMFVVDLTGGEVEMRAIPKMGRNAVSSYELFMDDFRVPGSALVGEEGRGFTYLLDGINPERILLAHESLGIGRAALRRAVRYAGERVVFGRPIGQNQGIAFPLAEASMRLDAAELAARHAAARYDSGEPCGKEANTAKYLCADAAFAAADAAVQTHGGFGYAREYHVERYFRESRLMRIAPVSQEMVLNYISEHVLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E864</accession>
    <name>A0A1H6E864_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93134">
        <property type="protein sequence ID" value="SEG93134"/>
        <property type="gene ID" value="SAMN04489712_13722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="28200" checksum="A6EEE7F00434A0D9" modified="2017-01-18" version="1">MSKPSYRDIAAILRREIEAGDYERGSLFPPEPALAERFNTTRATINNVLRVLRAEGLVSTQQGRGTTVTAMTPRINRDAVSRYRKDSRERARGAFDSEVRKLGMEPRSDLTVGRVVPPAEVAAILNIEPGQEVVVRSRRMYADGVPVQIAPSYIPLDIAAGTVLEEQNQGQGGMVSRMADLGYRQVRMTESITVRPPNDDEADFLQMSADQRVYVITHVGWTADNRPVEVCVHVMPTHYWTLEYGWDVDPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9S2</accession>
    <name>A0A1H6E9S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93704">
        <property type="protein sequence ID" value="SEG93704"/>
        <property type="gene ID" value="SAMN04489712_14017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="445"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="533" mass="57129" checksum="BCB4C7948C175530" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAB9</accession>
    <name>A0A1H6EAB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_15023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94730">
        <property type="protein sequence ID" value="SEG94730"/>
        <property type="gene ID" value="SAMN04489712_15023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="42844" checksum="B3770B17CA010736" modified="2017-01-18" version="1">MSRRDEVEHVLRAWNAHEVARGLSPIIDFDCAPTAAEPEPADRLTTYRRLAEMLPHLTGPVAVRVRADLAYLGALLGEHPPLADYVRATQGCAAAGWPAEYVTERAEAARTALADLGIKWGPNTNSDLRELEGWLDVRDAPDAIRQAAEELEPAVREATGSTAPYTLTIEAAEVDAYWGYWLDGAGERVRLRLNLTNAEFTQVSARQFALHEVLGHGLQSASLAARAQAEDVPWVRLLSVHAPQQVMLEGLAQAFPLTITPDDKPLTTRVRIEHYTQLVRAEAHQALNAGTPAIDCADHIRARVPWWNDATIAGLLADRGADPQLRTYMWAYPAGLDWFAALAEADARVIREVLHAAYRDPLTPAELADLWPAGPPIGGPGGPVRLRKPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBN6</accession>
    <name>A0A1H6EBN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000072">
        <property type="protein sequence ID" value="SEG95177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95177">
        <property type="protein sequence ID" value="SEG95177"/>
        <property type="gene ID" value="SAMN04489712_1722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG95177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="29096" checksum="7BF1252F90972FEA" modified="2017-01-18" version="1">MTGQHGPGHDHPARPDAPPMDAGQAQALAGRIRRSIAEVERAWGVLADLVCQAHQGQAWRALGYASWGEYAHAEFGIGRAHAYRLVDMATTAEQLHGAVAEVVASLTGPVVSPAGDALALLSGRALRDVRGRVDQVAAVLAERLQQATTAEGKLTSGQVAELVRQAVAEVRALAPPAQAGRSPAAPRDPDGPIAEGRALVERLYAGAAEIGRMCLEIAPAYLSEDQASRWLEPFADEIGLTLEDVLARRRYAITGDRRAVRAFLWPPHPRSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S320</accession>
    <name>A0A1H5S320_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="10" type="ORF">SAMN04489712_10160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45002">
        <property type="protein sequence ID" value="SEF45002"/>
        <property type="gene ID" value="SAMN04489712_10160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="344"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF45002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="502" mass="50734" checksum="27DD446DF0E4D374" modified="2017-01-18" version="1">MTTISLASTAPSALEVDAIVIGIVPDEPAAPDAAGPGLRTAGGAQDVDRALDGRLAAALSALGATGKAGEITKLPTLGALTAPVVVAAGLGADAGPDALRRAAGAAVRSLAGSARVALALPAGSAEEVAAVALGALLGNYSFGRYRTGERKEPVAELTVLTGEETGGAVEALERARTLASSITLVRDLVNTPPSDLGPEDLAQIAAKVAGEVGLGVQVLDEKELAEGGYGGIVGVGQGSVRPPRLVRLSYTHPEAERTVVFVGKGITFDTGGLSLKPADAMDWMKSDMGGAGAVLGALRAIALLKTKVNAIGYLPLAENMPSGTAQRPSDVLTIYGGKTVEVLNTDAEGRLVMADALARSGEDSPDLLVDVATLTGAQLVALGTRTFGVMANDDEVRERVVAAAGRVGEASWPMPLPPELRKGLDSAVADIANISSERWGGMLVAGVFLAEFVPEGVRWAHLDIAGPAFNKGEPYGDTPKGGTGAATRTLVQIAEDVAAGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJE5</accession>
    <name>A0A1H5SJE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Barbiturase</fullName>
            <ecNumber evidence="3">3.5.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Barbituric acid hydrolase</fullName>
            <shortName evidence="3">BAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the hydrolysis of barbituric acid (2,4,6-trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>barbiturate + H2O = 3-oxo-3-ureidopropanoate</text>
            <dbReference type="Rhea" id="RHEA:18653"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58775"/>
            <dbReference type="ChEBI" id="CHEBI:77938"/>
            <dbReference type="EC" id="3.5.2.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">Inhibited by cyanuric acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; uracil degradation via oxidative pathway; malonate and urea from uracil: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The monomer structure is formed from three repeating units (RUs) that share the same structure as one another. The monomer and the active site possess nearly threefold rotational symmetry, to the extent that the active site possesses three potential Ser-Lys catalytic dyads, but one of the 3 active site surfaces varies in composition suggesting it is involved in confering substrate specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cyclic amide hydrolase (CyAH) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50615">
        <property type="protein sequence ID" value="SEF50615"/>
        <property type="gene ID" value="SAMN04489712_101233"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00582">
        <property type="reaction ID" value="UER00644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047694">
        <property type="term" value="F:barbiturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01989">
        <property type="entry name" value="Cyc_amidohydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014086">
        <property type="entry name" value="AtzD/Barbiturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043008">
        <property type="entry name" value="AtzD/Barbiturase_RUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043006">
        <property type="entry name" value="AtzD/Barbiturase_RUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043007">
        <property type="entry name" value="AtzD/Barbiturase_RUC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09663">
        <property type="entry name" value="Amido_AtzD_TrzD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02714">
        <property type="entry name" value="amido_AtzD_TrzD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="RU A" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="230"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="RU C" evidence="3">
        <location>
            <begin position="253"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF50615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="368" mass="38427" checksum="326ED77E38A4C7AB" modified="2017-01-18" version="1">MPDPIEVRKVPIESVTDASGLARLIDDGVIEADRVLAVVGKTEGNGGVNDYTRILADRAFREVLLAKGTRTAEEVAEVPLVWSGGTDGVLSPHATIFASVDPATVPTTDEPRVSVGVAMSEVIRPEDIGRPAMVEKVAAGVGAAMKIAGIEDAADVHYVQTKTPLLTLDTINEAKGRGRDVVTEDTLKSMDISNSTTALGIAVALGEIEMPDAGRIHRDLSLYSSVASCSSGVELDRAQIVVVGNVRGIGGRYRIGHSVMRDALDADGIWAAIRSAGLDLPDRPHPDDLDGRLVNVFVKCEADPSGSVRGRRNIMLDDSDVHWHRQIKACVGGVAASVTADPAVFVSVAAVHQGPSGGGTVAAIADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SP42</accession>
    <name>A0A1H5SP42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Right handed beta helix region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52295">
        <property type="protein sequence ID" value="SEF52295"/>
        <property type="gene ID" value="SAMN04489712_101300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284190" evidence="2">
        <location>
            <begin position="34"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="360"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="466"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF52295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="709" mass="73413" checksum="9EF2D45EA0A5D298" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SQ35</accession>
    <name>A0A1H5SQ35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52540">
        <property type="protein sequence ID" value="SEF52540"/>
        <property type="gene ID" value="SAMN04489712_101310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF52540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="56" mass="5870" checksum="3203943016D8C4BF" modified="2017-01-18" version="1">MDIGGLHFTYLNVALFGLALFLLTGVISFLRQGLKVGALILLVLTALAVTAGALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T5A7</accession>
    <name>A0A1H5T5A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57338">
        <property type="protein sequence ID" value="SEF57338"/>
        <property type="gene ID" value="SAMN04489712_101468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF57338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="28727" checksum="6EAB19723C2C1780" modified="2017-01-18" version="1">MSYQTLQVERHGHVGWLVFDRPDRRNAMNNAMRDELRAAWTELGADPRVRVIVNTGNGPAFQTGADVMELATDGVGMERYRASVEKWDLGFTSWFLHIDKPVIAAVNGVCAGGGLHFVADADIVLAASDATFTDPHVSVGQASTIEMIGLMRKMPAEAVLRMALVGRYERMSAARAYELGMVSEVVDPPERLREAAQELADKIARNSPAALAATKRALWGALEQGLTDACRAGAAELTGLWGHPDQTEGPAAFAEKREPQWKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T6L8</accession>
    <name>A0A1H5T6L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58473">
        <property type="protein sequence ID" value="SEF58473"/>
        <property type="gene ID" value="SAMN04489712_101504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF58473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="16932" checksum="3F51977130625F93" modified="2017-01-18" version="1">MHPSLEQLAPLIGRWSVQPKVPGLGAAWTEFAWHEGGLFLRQYSDVEEIPPDAPQEWREHAPFPTTALIGLDDAAGGFTMLYADARGVHRVYRMTFDGRVWTIRRDAPGFDQRFTGTLNGDTIDGRWEIRTDGEDWRLDFEVAYARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5THK3</accession>
    <name>A0A1H5THK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide (TPR) repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62233">
        <property type="protein sequence ID" value="SEF62233"/>
        <property type="gene ID" value="SAMN04489712_101621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="160"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF62233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="886" mass="98373" checksum="F91F923E589F5AB8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TLT3</accession>
    <name>A0A1H5TLT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-lactate dehydrogenase complex protein LldG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63765">
        <property type="protein sequence ID" value="SEF63765"/>
        <property type="gene ID" value="SAMN04489712_101672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="115"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF63765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="22565" checksum="E2422D8F4116519F" modified="2017-01-18" version="1">MSRERVLRSVRAALGEARGTEVNVPRDYHHRLTGEEAGSRADVVALFSERVADHRATVRHVGADELATTVAAALWAREAKRIVVPDDLPYGWLAQLEGVQALADAGTVDVAVLDAVDGVVTGCAAAVARTGTVVLDGGRAQGRRALTLVPDYHLCVVHADQIVGTVPEAVARLDPYRPLTWISGPAATLDLGLRRVPGVHGPRELEVLVVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TPW7</accession>
    <name>A0A1H5TPW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64912">
        <property type="protein sequence ID" value="SEF64912"/>
        <property type="gene ID" value="SAMN04489712_101706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF64912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="27007" checksum="EE69BCECA7B610D6" modified="2017-01-18" version="1">MGDVRVEIQGSITTIWLDRPERRNAVDGPMAAELREAFQAFEADPGQQVAVLAGAGGTFCAGADLTAVGDPARRNELDPDGGGTGPMGPTRMALSKPLIAAISGHAVAGGLELALLADLRVVERDAVLGVFCRRWGVPLIDGGTVRLPRIVGLGRALDMILTGRPVQADEALAIGLANRVVEPGEAVRAARELAAEIAGFPFGCVLADRSSTYAALDLPLAEALRAEGAAGVPIVAAEGVAGAARFTAGEGRHGAFSSKRTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UWB9</accession>
    <name>A0A1H5UWB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="3">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuB</name>
        <name evidence="5" type="ORF">SAMN04489712_10236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78751">
        <property type="protein sequence ID" value="SEF78751"/>
        <property type="gene ID" value="SAMN04489712_10236"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01035">
        <property type="entry name" value="LeuB_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023698">
        <property type="entry name" value="LeuB_actb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="4">
        <location>
            <begin position="10"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF78751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="353" mass="37453" checksum="E1BEFE62CCF57DC3" modified="2017-01-18" version="1">MASSSTRTIRLAVIPGDGIGPEVVAEGLKVLDAVAPDHGLAFDRTPYDLGAERWHRTGEVLPDSVLEELRGQDVILLGAVGHPSVPSGVLERGLLLRTRFELDHYVNLRPVKLFPGVATPLAGATAEDIDMVVVREGTEGPYTGVGGVLRKGTGHEVATQESVNTAHGVERVVRYAFEQAAARPRRKLTLVHKDNVLTFAGDLYQRTLQRVAAEYPQVTTDYCHVDAATMFFVTDPGRFDVIVTDNLFGDIITDLGAAIAGGIGLAASGNINPDRTAPSMFEPVHGSAPDIAGRAKADPTATILSVAMLLDHVGAPEAARRVERAVSADLAERGDAVRATHEIGDAITKRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UYC2</accession>
    <name>A0A1H5UYC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized conserved protein, DUF58 family, contains vWF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79408">
        <property type="protein sequence ID" value="SEF79408"/>
        <property type="gene ID" value="SAMN04489712_10263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="3">
        <location>
            <begin position="163"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF79408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="314" mass="33131" checksum="5146827B96DB2E9F" modified="2017-01-18" version="1">MRALAWLVCAAALAFAAGALPSLALFALAVGIVIMVAGAAVTVLVARARMTAGRVVMEREIPEDRPLRLRFDVRLPARLPACVHVRVGRRAWVRLGEGGGVVEVPIDRRGAYRVEASRLRVGDELGIFRVTVRVGEPERVLVLPVPDGGAPAAPARGPSAEHIEPDGLRPYVPGTPVSRIHWLSLARGMGLHERRMGPPPTGLPLVVVDTSADPDPRAVDWVARTAAGLVRRLSRDGGCAVLLPGDATATTVNDEKSWRALHRRLAVLDAGDGPVQQPAGVAGVVRFPPGHDLGPPPPPLPPGVVPANPGREEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V340</accession>
    <name>A0A1H5V340_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81683">
        <property type="protein sequence ID" value="SEF81683"/>
        <property type="gene ID" value="SAMN04489712_102142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="264"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF81683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="386" mass="40264" checksum="6D6B5FAEF2D59E3E" modified="2017-01-18" version="1">MAEPVIVEAVRTPQGRRGGWLAGLKPMAVLAHALDALVQRSGIDPAEVGQVFAGCVTQAGEQGGHLGRHSWLYAGLPWQTGVTTIDAQCGSSQQSVHLAAAMIAAGVVDVAVGCGVEVMSRAPLGSNVLPANPRPDDWSIDLPDQFQAAERIAARRGLTRAELDAFGVRSQALAAKAWADGRFDREVAPIEAPVLDAEGAPTGEVRTVDRDQGLRETTAEGLAKLRPVMGEGALHTAGTSSQISDGAAAVLLMSRAKAEALGLRPRARIRAQALVGGEPYYHLDGPVQATERVLAQAGMTIADPDLFEINEAFASIVLSWARVHEPDLDKVNVNGGAIALGHPVGATGARLITTALHEMERRDGSSALVTMCAGGALSTATILERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VKZ1</accession>
    <name>A0A1H5VKZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein TerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87508">
        <property type="protein sequence ID" value="SEF87508"/>
        <property type="gene ID" value="SAMN04489712_102348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF87508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="20239" checksum="0CF6982D6C23B559" modified="2017-01-18" version="1">MGVSLAKGGNVSLTKEAPGLTAVTVGLGWDVRSTTGADFDLDASALLVDESGRVLSDQHFVFFNNLRSPDGSVEHTGDNLTGEGEGDDEQIKVNLSAVPAEAAKIVFPVSIHDADSRGQSFGQVRNAFIRVVNQADNSELARYDLTEDASTETAMVFGELYRHGSEWKFRAIGQGYASGLAGVAKDFGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VR17</accession>
    <name>A0A1H5VR17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar or nucleoside kinase, ribokinase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89680">
        <property type="protein sequence ID" value="SEF89680"/>
        <property type="gene ID" value="SAMN04489712_102422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="4">
        <location>
            <begin position="77"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF89680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="377" mass="39515" checksum="7E3B8B87E2F8B418" modified="2017-01-18" version="1">MAAPGLGAPPELPFDDPCADRERAGPRPRTAGGPAPGDDAGGLDVFLAGRVFMDMIFTGLPGLPPPGTELVTDGLGSAPGGIANIAVAMSRLGLRTGLATTVGDDMFGAYLWRTLSEQEGVDLTWSRRAGGWPTPVTVSMAYDSDRSMVTYARPLPPSADEPVTVPPHASTCFIDIDRPVPAWALAMRRQGSLVFADVGWDPTETWSTDVLDRLAAVDVFLPNAVEAMAYTRTRHPADALEALALRVPTVVVKQGARGAIAIDSTTGERAEAAALPVEALDTTGAGDVFAAGFVFGTLAGWPLLQRLRFANLCAGLSVRHYSGSLGAPCWGEIAAFGETTEVAPEILADYEFVVPYIPEAELGSGPDSVTRAQPTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VSV7</accession>
    <name>A0A1H5VSV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90223">
        <property type="protein sequence ID" value="SEF90223"/>
        <property type="gene ID" value="SAMN04489712_102441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF90223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="99" mass="10513" checksum="0861DE02485ED78F" modified="2017-01-18" version="1">MAIEVRIPTILRNLTDGAKAVEGKGGSLDELITDLDSRHPGLRDRLVDAKGLRKFVNVYLNDEDVRFLGGLDTEVSDGDTVTVLPAVAGGAADLPGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VXA8</accession>
    <name>A0A1H5VXA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91922">
        <property type="protein sequence ID" value="SEF91922"/>
        <property type="gene ID" value="SAMN04489712_102504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF91922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="382" mass="40839" checksum="E56F68073A4DA428" modified="2017-01-18" version="1">MREYLLVMLVAAVITYLTTPVVRAFSVRFGAMTAVRDRDVHAIPTPRMGGLAMFFGMVGGLVTASGLPVMRRVFEDSDIDRGLLLAATLIVLLGIADDRWEIDALTKFAGQVAAAGLFIMNGIQLFVIPLPNGQPLVLPPEYGVPLTVFLVVATINAVNFVDGLDGLAAGVVGIAAMALFSYASLLSFAERLTRITPATLTAAVLVGMCLGFLPHNFNPARIFMGDTGSMLIGLLLSGATILLTGQFDSAVIGPVTQIPVFLPVLLVVLVMAVPYIDMLLAVWRRTNQGKSPFAPDKLHLHHRLLELGHSHRRAVLVMYFWVGLLASCVVGLSFIPSVLLVLSVAGLVAVAGTVVLIAEPWRRRRPKAATGAVSPARPHEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W3E5</accession>
    <name>A0A1H5W3E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93960">
        <property type="protein sequence ID" value="SEF93960"/>
        <property type="gene ID" value="SAMN04489712_102573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF93960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="347" mass="36601" checksum="8D82B76169E646DB" modified="2017-01-18" version="1">MNREIAVVAFVQTRHAADSGGLSEVEMLAPVITEIKERTGVHRFGFTCSGSCDYLEGKPFAFVTALDAVGAWPPISESHVEMDAAWALYEAYVRLLHGDVDTALVYGFGKSSQADVRKVMTAQLDPYYLAPLGPDQVSLAALQARAYLERAGAKEDDLRAVAARSRAAGRDNPYALHLEDPDGSQGYDVAPLRPYDIAPDTDGAAAIVLAAGDKARELCERPAWITGIDHRADAHGLGVRDLSRSESARIAGERAGAAGVEVAELHAQFSHEELILREALGLGDDVLVNPSGGALSANPIMAAGLIRIGEAAARVQDGTAAKALGHASSGPCLQQNLVCVLEGEPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X831</accession>
    <name>A0A1H5X831_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4234 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07783">
        <property type="protein sequence ID" value="SEG07783"/>
        <property type="gene ID" value="SAMN04489712_103127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025328">
        <property type="entry name" value="DUF4234"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14018">
        <property type="entry name" value="DUF4234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4234" evidence="3">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG07783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="18509" checksum="5D8B5AD418157C3B" modified="2017-01-18" version="1">MGYPQHGQPQQGYQQYPQHAGHAPVPAPQHAPAATGSNMKRRNVLGVWLGLPIITFGIYGLVWIYKVHNELARYDRRIPDQSANALLSVIFGWITLYIWPLIMWLKLAGHIRQAQQAAGLQPTCSTGLGLLLGLFGFGTLYYQLELNKVVDRYGGTPPYQPVPLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XWU6</accession>
    <name>A0A1H5XWU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16234">
        <property type="protein sequence ID" value="SEG16234"/>
        <property type="gene ID" value="SAMN04489712_103448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG16234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="488" mass="52262" checksum="9C39CC82EF802C20" modified="2017-01-18" version="1">MPVNAVREYGRVADCETEKCGGENAGRWRLPRSFTLLWSGSAASQFGRMGVAIANPLLALSLTGSPVFAGWVTAASTFPSLLLHLPAGVLVDRFDRRLVMMTCQFARLLIALLLIVSLYLTENPLLLIPAAAGDGVFSALYDLAEVTAIRQVVPDDQLPDAMGKNEARSHIALLLGRPLGGLLYDAGRLFPYAANAFFSLISLITLSFVRIPVPETEAWHGGTMLQEFRDGLARLWHDHFLRQILIVCAITNFAFQTIFLLLIVQAERRIGSATMIGVLFTASGLGGALGALATPRILRRALHGAESTRVVLVCVWGWSAMTTIVVVFDHPLVGLAAWGGISFIGAHLNVALAIYRAKAVPEKLMAKVTGVSGFVTRGAVPLGALVAGYLVSNLDTRHAALTVALATLGVSLWTTWQWHGGRSGLARRRPVAGLARWASELRAERVLPGRPRQRRSVLAADAAEDTAAPSGLDASVARTADPEAAPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XX29</accession>
    <name>A0A1H5XX29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16202">
        <property type="protein sequence ID" value="SEG16202"/>
        <property type="gene ID" value="SAMN04489712_103447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG16202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="58" mass="5972" checksum="1B54AD3814239CDD" modified="2017-01-18" version="1">MQHPATGSAEALVDVSKLTLAEIDGLPELHPLGETLREAIDTSPVIAAAGFDSGLTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YL58</accession>
    <name>A0A1H5YL58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24382">
        <property type="protein sequence ID" value="SEG24382"/>
        <property type="gene ID" value="SAMN04489712_10455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG24382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="35360" checksum="46DF059A1C14672B" modified="2017-01-18" version="1">MSQSVPAMAVTHRLVSSSAGRVHLVEQGSGPLVLLVHGFPESWYSWRHQLPVLAAAGYRAVAVDVRGYGRSSKPADVAAYRMLELVEDNVAVVRALGERTAVIVGHDWGATIAANSALVRPDVFRAVGLLSVPYAPRGGPRPSEIFARMGGAEEFYVSYFQQPGRAEAEIEPDVRGWLAGFYAALSADTMPPADAPDPHFVSTGGTLRDRFPAGRLPAWLSEDDLDVYAAEFERTGMSGALNRYRNVDRDWADLADFDGAPITQPSLFIGGALDASTTWMADAITAYPATLPGLVSSHILDGCGHWIQQERPTQVNDLLTGWLSSLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YLZ3</accession>
    <name>A0A1H5YLZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25098">
        <property type="protein sequence ID" value="SEG25098"/>
        <property type="gene ID" value="SAMN04489712_10484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043767">
        <property type="entry name" value="DUF5713"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18977">
        <property type="entry name" value="DUF5713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG25098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="113" mass="12741" checksum="4E98263311F63132" modified="2017-01-18" version="1">MAITNQQVTGHPFLRGLYADEYFPDHVVDKGKAVLLRLCERIEAERPSDLAALYALTHVATEEFNALEAEFEAAGSEIETFAREEIAEDFWFVASAYGFAEADIEELIAPRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YNJ6</accession>
    <name>A0A1H5YNJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25222">
        <property type="protein sequence ID" value="SEG25222"/>
        <property type="gene ID" value="SAMN04489712_10488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG25222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="47" mass="4966" checksum="2B574E602A259663" modified="2017-01-18" version="1">MIAGRWIDVVVLGTVTACDGARSGLRMLTGALGPRVRCPVALYGRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YR99</accession>
    <name>A0A1H5YR99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25866">
        <property type="protein sequence ID" value="SEG25866"/>
        <property type="gene ID" value="SAMN04489712_104110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG25866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="10043" checksum="068B4EA2CB837DE9" modified="2017-01-18" version="1">MQITINAGTRLVVAVGDPVPGNRNNCQAYRDSCIDRALAGRRGIADSIYRDNLGVIVPYRRPRRCPSSRKTSTRRSACARIEQTMTHLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZAA1</accession>
    <name>A0A1H5ZAA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="10" type="ORF">SAMN04489712_104435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32994">
        <property type="protein sequence ID" value="SEG32994"/>
        <property type="gene ID" value="SAMN04489712_104435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG32994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="14339" checksum="45E74C9252704A7F" modified="2017-01-18" version="1">MPPRSKVGAKKVRRKEKKNVAHGHAHIKSTFNNTIVSITDPNGNVISWASSGHVGFKGSRKSTPFAAQQAAEAAARRAMEHGMRKVDVFVKGPGSGRETAIRSLQATGLEVGSIQDVTPVPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZF56</accession>
    <name>A0A1H5ZF56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34901">
        <property type="protein sequence ID" value="SEG34901"/>
        <property type="gene ID" value="SAMN04489712_104522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045931">
        <property type="entry name" value="DUF6350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19877">
        <property type="entry name" value="DUF6350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG34901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="551" mass="56973" checksum="F679977635B25C59" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZUI8</accession>
    <name>A0A1H5ZUI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG39861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG39861">
        <property type="protein sequence ID" value="SEG39861"/>
        <property type="gene ID" value="SAMN04489712_1053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="149"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG39861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="383" mass="41835" checksum="B1CC3D0CB84155A0" modified="2017-01-18" version="1">MEDNRPTLGVGMVGHAFMGRVHSQAWRSVGAFFDLPVRPEMTVLCGRSRQRVDAAAAEMGWAHAETDWKALLRRDDVHIIDICTPGDSHAEIAIAALQAGKHVLCEKPLANTVAEAEAMTEAARDAAARGVRSMVAFNYRRVPAVALARDLVAAGRLGEIRHARAQYLQDWIVDPEHPLVWRLQRDKAGSGALGDIGAHIIDIVQFVAGQRVTGVSGLTETFVKERPLPEEDGVGEVTVDDAALFIGRLEGGAMASFEATRFAAGRKNAMRFELNGSLGSLWFDFEAMNELWFHDHTLAAEEAGFRRILVTESDHPYAGAWWPPGHGLGYEHTFTHEVKDFLEAIAAGTDPTPSFADGLRVQRVLDAVERSAADEGCWSPVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A200</accession>
    <name>A0A1H6A200_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42471">
        <property type="protein sequence ID" value="SEG42471"/>
        <property type="gene ID" value="SAMN04489712_105140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG42471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="239" mass="26906" checksum="04B2A07911EAAD00" modified="2017-01-18" version="1">MELTVDELAARAGVSVRTVRYYAGRGLLPPPRLRGRTGLYGAEHLARLELVRELQSLGLTLAAIEHHLQRIPEDAPPEDLALQRALLSPWTPDRPEEMDRHELDRRAGRHLDDDVLKRLEALGVVEQASGDTVRVISTGLLRVGAELAALPLPLETLAASHEAVERHTTALAEELQRNFQDSVVRPYRERGRQPREREMLLEMANRLKPLMIQSLVTSFQHAVDRAIRKSVPGDEDDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A3G9</accession>
    <name>A0A1H6A3G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase / fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_105187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43268">
        <property type="protein sequence ID" value="SEG43268"/>
        <property type="gene ID" value="SAMN04489712_105187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="10"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="487"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG43268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="644" mass="70805" checksum="FEC81EDCA196EFD1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9D4</accession>
    <name>A0A1H6A9D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45343">
        <property type="protein sequence ID" value="SEG45343"/>
        <property type="gene ID" value="SAMN04489712_105297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG45343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="284" mass="31872" checksum="FA5F64BF866D7736" modified="2017-01-18" version="1">MTEHGPTTRQRRLAAELRKLREANGLTMDRAATALGWPQSKLSELETARQIPKTGDVEAILATYGGVDQAVKLALLQLVRDVRQRGWWASFGDVLSGSYAELEYAADRIRIWQVQLVPGLLQTEDYARTLIRRHFPDESDAEIDRRVQVRVTRRAMLTRQKPPRLEVLLAEEVIRRPVGGREIMRGQLGALLHAGQRPNVSIRVVPISAGDYPSMGTGGVVLFEFDESSVVDLSVAYLETMAGSRYEEDISQVRACSLMYDRIAEFALTESDSADLIRTTMKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AAU0</accession>
    <name>A0A1H6AAU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45863">
        <property type="protein sequence ID" value="SEG45863"/>
        <property type="gene ID" value="SAMN04489712_105328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025443">
        <property type="entry name" value="DUF4307"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14155">
        <property type="entry name" value="DUF4307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG45863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="14019" checksum="35A60BF01065531D" modified="2017-01-18" version="1">MSTSVSQAPDRRPRRGGRLGYVIIGLVVAVCAVGWAVIMANAGRTPGISQQTITYRILDDSRVEVRWQVAKPSGKRVRCLVDAVDVNFAPVAEREVIVPAGQSTLKRTDLLQTTRRATAARVKECRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AEN9</accession>
    <name>A0A1H6AEN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette, subfamily F, uup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47213">
        <property type="protein sequence ID" value="SEG47213"/>
        <property type="gene ID" value="SAMN04489712_105408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="282"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="519"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="314"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG47213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="586" mass="64979" checksum="67E028AAFCD429DE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJX2</accession>
    <name>A0A1H6AJX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48702">
        <property type="protein sequence ID" value="SEG48702"/>
        <property type="gene ID" value="SAMN04489712_105491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG48702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="774" mass="84409" checksum="DA1F771D607822E9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B458</accession>
    <name>A0A1H6B458_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-acetyl-ADP-ribose deacetylase (Regulator of RNase III), contains Macro domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55007">
        <property type="protein sequence ID" value="SEG55007"/>
        <property type="gene ID" value="SAMN04489712_106196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="357" mass="39549" checksum="BA0633E57EB41CAD" modified="2017-01-18" version="1">MEKEVKPMIVERTGNLLRDDAQALVNTVNTVGVMGKGLALQFKRAFPANFDAYAQACKDGRVRPGRIFATPFADDRWILNFPTKRHWRQPSRLEDIRSGLDALARTVVELNLTSVALPPLGCGNGGLDWEVVRRLIIERLGGLDAEIRLYGPGTPAPEDMPVRSRRPPLTKNRARLLAALRRYAILAFEAGVAVDVNTSLLEAQKVTYLLQGAGLRLGYRFERGHYGPFSADLNREISAMEGHYLIGYGDGTSGAKADLRLLSAADQAESLITDDMAFQSAWFQVSRAAFGYEYPDGMELLSTVHFVAARQPGAADPDTVATEVARWSERKRRLFSAEDVHCAWRQLHEAALLRPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B775</accession>
    <name>A0A1H6B775_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_106314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56462">
        <property type="protein sequence ID" value="SEG56462"/>
        <property type="gene ID" value="SAMN04489712_106314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="55"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG56462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="17204" checksum="6B61147C9CBCFEDB" modified="2017-01-18" version="1">MTYTLAELPEHVGEELMCSGWAELGAADEQAFAEATFLREDFLGRPPSNGDPYGDRMISGFLLLSILVAFHKRDLDVDLEGRYGLNYGVDRVRFLRPVLAGQRVRVRAELVEAREKAPGRMRLVTRNVLEVEGAEGPAMIADWITLFVDPKAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BEC9</accession>
    <name>A0A1H6BEC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation/acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <sequence length="536" mass="55854" checksum="BAAD74CEEF812EAD" modified="2017-01-18" version="1"> </sequence>
</entry>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="94" mass="10391" checksum="DEC97D65415C2177" modified="2017-01-18" version="1">MYDTLTRDPLHVSLSMIQGHNVELPPAPDPRHQPLAYLYSLEWDGQLADPQPGHYDKDSQTWMLPPGVPSAGVNTNTSTSCYAGSDTCRDDVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BIE0</accession>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="30775" checksum="C4568DFEDA1F7FC2" modified="2017-01-18" version="1">MSEPPVRGAGRAEERAEAAMSEAETAGRAEAGARELLEIRGLQVVFDGFRAIDGVDLTVRQGELRFLIGPNGAGKTTLIDVITGLTRPSAGSVRFAGTELVGRKEHRIVRLGIGRTFQTSVVFEELTVVENLDLAATFRRPLWALLRRRRGVSDTVAEALETVGLTDLAERPAGVLSHGQRQWLEIGMLIAQRPRLLLLDEPVAGMSRQERERTGELLTTIAEDHTVVVVEHDMEFLRRYASQVTVLHEGRVLVEGDVAQVRADPRVQEVYLGRTAEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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                <person name="Submissions S."/>
            </authorList>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG60307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="27709" checksum="8B6E0BE938391D2C" modified="2017-01-18" version="1">MTSTGANGAPPFEMTAGRVRLDGREVLHGIDLRVEPGEVLAVLGANGSGKSTLIRALLGLVPLSGGRTHIYGSPPARFRDWKRVGYVPQRLTVGGGVPATVREVVASGRIARQSRLRPFSSAADRAAVRRALETVGLADRAGHPAQRLSGGQQQRVLIARALAGEPDVFVMDEPTAGVDAASQAALARTLRELVRQGRTIVLVAHELGPLEPLITRAVVVEAGRIAHTGAPPAPEGECARPGHQHLHPHAPGTEPAPLTTWNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUX8</accession>
    <name>A0A1H6BUX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPW repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10826</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64460">
        <property type="protein sequence ID" value="SEG64460"/>
        <property type="gene ID" value="SAMN04489712_10826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005530">
        <property type="entry name" value="SPW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03779">
        <property type="entry name" value="SPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="11688" checksum="6C49FF14934D3AFE" modified="2017-01-18" version="1">MGRFAWQDAVAFVAGLAVVLAPELWADGAGRQPLMVLGALLALAGLYALLGAAGPSAWTSTAFAVLVFVSPWAFGFTGEGAAAWTAWIAGGAAAIVGLWTATQTLPARAEAERAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BVR5</accession>
    <name>A0A1H6BVR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">whiA</name>
        <name evidence="8" type="ORF">SAMN04489712_10855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64798">
        <property type="protein sequence ID" value="SEG64798"/>
        <property type="gene ID" value="SAMN04489712_10855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WhiA_N" evidence="6">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="7">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="5">
        <location>
            <begin position="221"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG64798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="34951" checksum="AA247F627DFCC18B" modified="2017-01-18" version="1">MAMTGVVKDELSRLSIMKPCCRKAEVSTLLRFAGGLHLVSGRIVIEAEIDTGAAARRLRKDIAEVFGHTSDVVVLAPSGLRKGNRYVVRVFREGESLARQTGLIDNHGRPVRGLPRHVVAGAACDAESAWRGAFLAHGSLTEPGRSMSLEVTCPGPEAALALVGAARRLKVHAKAREVRGVDRVVVRDGDAISALLTRLGAHDSVLAWEERRMRREVRATANRLANFDDANLRRSARAAVAAGARVARALEILGDDAPEHLVAAGKLRLEHKQASLEELGQLADPPLTKDAIAGRIRRLLAMADKRASDQGVPGTEANLTAEMLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXT4</accession>
    <name>A0A1H6BXT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65524">
        <property type="protein sequence ID" value="SEG65524"/>
        <property type="gene ID" value="SAMN04489712_108112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG65524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="49" mass="4943" checksum="E8328A8DF6A664DE" modified="2017-01-18" version="1">MRPTIKINPWKGGAGRYAILLVGLGAAGVAIGWAGPEAAAGAGSLIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BY04</accession>
    <name>A0A1H6BY04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-sulfur cluster biosynthetic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65337">
        <property type="protein sequence ID" value="SEG65337"/>
        <property type="gene ID" value="SAMN04489712_10896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="2">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG65337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="124" mass="13271" checksum="FAF1AACF6A2FAD03" modified="2017-01-18" version="1">MSETETPAAEQDVPEQAGAAPAIAAEHEEILEALKDVVDPELGINVVDLGLVYGIDVVDEVATLDMTLTSAACPLTDVIEDQAHGALEGLVKDVKINWVWLPPWGPDKISEDGREQLRALGFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C302</accession>
    <name>A0A1H6C302_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66756">
        <property type="protein sequence ID" value="SEG66756"/>
        <property type="gene ID" value="SAMN04489712_108221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG66756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24298" checksum="94A3E5E69D53906B" modified="2017-01-18" version="1">MDDVEAIAALRDPVRRRLYEYVAAQDHEVSRNEAAEAMGVQRTLAAFHLDKLAEAGLLETTGRRLTGRSGPGAGRPAKLYRRAAAERVVSVPPRDYRTAAELLAEAAEEAELDERLWRAARLRGRELARDAGPVRGLDEAEALLARRGYEPVREQTPAGAVLRMRNCPFHVLSERFPPLVCGMNLALLEGAFEGSADLAPRMDPRPGWCCTVLAASKNNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C3Z5</accession>
    <name>A0A1H6C3Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized membrane protein YbhN, UPF0104 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_108252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67086">
        <property type="protein sequence ID" value="SEG67086"/>
        <property type="gene ID" value="SAMN04489712_108252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG67086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="352" mass="35940" checksum="087913BEB5421639" modified="2017-01-18" version="1">MTPRGWSRLRVLAAVVIIAVLARRLGTEAFVDGVRPVDGEAVLAALAIGLLTTAAGAWRWWLVARRLGLPLPPGTAMADYYQAQFLNAVLPAGVLGDAHRAVRHGRRAGDLGRGVRTVLLERVGGYVVLIPAGVIALLMEPSLAGALARGLLPDPGVTAAVPAGLAVVGVPAAVWARREAIAARLRGAVAAAVADTRRGLLARDTWPGVLALSAAALLGYLALFLVAARTAGSAAPIGRLLPLLLLALLAMALPVNVGGWGPREAFCAVAFGSAGLGAGQGLTTAVTYGVLTFVASLPGAAVLLARRGAGTRETPVGEAPAEKTPVREAPVVLDAGVVRPAEDRQVVGERSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8G3</accession>
    <name>A0A1H6C8G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69241">
        <property type="protein sequence ID" value="SEG69241"/>
        <property type="gene ID" value="SAMN04489712_10964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="27008" checksum="3ACFD065C9DA1B1A" modified="2017-01-18" version="1">MRFWKRAAKRQVHPLHMGLVGRKQLSVSLRPAEWAELIDSLAWQDAKRRSAWAPPEEARELLMPIVRAVLEDVPPDGTLQVTTDLRGLAPQDKAGPRRTLPAPPAVERTEWYVTDPWLRLRADLRDGSVLDLSVTDHVRHRRTEKRSRSGRLKIKVKTKGVARVSATRTLPRGAAVRRPATPPPPFVSVRVREGERTVIRTDAKLAVDAQVRPTPERILDVLTELFRWTPPKAARRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CBB6</accession>
    <name>A0A1H6CBB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70198">
        <property type="protein sequence ID" value="SEG70198"/>
        <property type="gene ID" value="SAMN04489712_109149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="51" mass="5955" checksum="2476DECBD5B3F056" modified="2017-01-18" version="1">MASVVNKIRRWLHTPQGRQARAHAERLARDPRNRARLRGLLNRRGGSSHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCX7</accession>
    <name>A0A1H6CCX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70722">
        <property type="protein sequence ID" value="SEG70722"/>
        <property type="gene ID" value="SAMN04489712_109196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="245" mass="25891" checksum="D08E5FEAE562F6E6" modified="2017-01-18" version="1">MTEESPRQVLDEVERLGRLTRARAHGAAVPFAVFGLLTLLSAVLYESPFGWSAPIGEIGGGGAYSLIPDWTASGYAGLEGNDRSAAVSIAFWLIVGPLCYLGCAWWYRERAERVGLAMRWRPWVIVGLALLVMMLLGVYLRGLPGGPLPASPQNVIGPLPAVALGLLVLAWAERSRGLAASALVYGTLSTMMNVYGLGQIPGGTIDPLTWPGNNLVLLAAVLLVGALASHLHTSARLRAATVQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDH3</accession>
    <name>A0A1H6CDH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71004">
        <property type="protein sequence ID" value="SEG71004"/>
        <property type="gene ID" value="SAMN04489712_109230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="37360" checksum="B21CA86E106E29CF" modified="2017-01-18" version="1">MNQESSKQDGYDVVVVGGGAAGLSGALTLARARRSVLVIDAAQPRNAPAGHVHGYLGHEGRPPAELLTVGRDEVTAYGGRIVNGEVVSAHALPGRDQEAGGFDVVLRDGTRHRARRLLVTTGLEDELPQLPGLAERWGRDVLHCPYCHGWEVRDGAVGVLGTSPFMAHQALLWRQWSERVTLFQHTAPEPTEEEREQLAARGVTVVTGRVESLQITGDRLTGVRLADGRTVPCEALVVSPNMTVRREMLASLGLRTTEHLMNGHFMGHYFATDPTGATEVPGVWAAGNVADLTATVIGAAAAGMRAAVAINGDLISEDTRLAVAARRVPFSAAAEREVADRVLGDRRHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CG90</accession>
    <name>A0A1H6CG90_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="9">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="11" type="ORF">SAMN04489712_109263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71356">
        <property type="protein sequence ID" value="SEG71356"/>
        <property type="gene ID" value="SAMN04489712_109263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="741"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="787"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="812"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium independence" evidence="9">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG71356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="879" mass="88470" checksum="B8ECD75D2341E9F9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIT6</accession>
    <name>A0A1H6CIT6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Gas vesicle structural protein</fullName>
            <shortName evidence="4">GVP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gvpA</name>
        <name evidence="7" type="ORF">SAMN04489712_11043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
            <location evidence="4">Gas vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72859">
        <property type="protein sequence ID" value="SEG72859"/>
        <property type="gene ID" value="SAMN04489712_11043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033172">
        <property type="term" value="C:gas vesicle shell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00576">
        <property type="entry name" value="Gas_vesicle_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00669">
        <property type="entry name" value="GAS_VESICLE_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG72859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="14697" checksum="E5B3E5F7CB11D6D5" modified="2017-01-18" version="1">MTVVQPPGGGRGGPGAGGLADVIDTILDKGLVIDAYVSVSLLGIQLLTINARVVVASVETYLQFAEATNRLDLSAQEKPGVGDLVGGLLPGGSAKSDEVSAADLQALQAADEEREPELVRAERDEAPEPRPRRRRADREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CK18</accession>
    <name>A0A1H6CK18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73341">
        <property type="protein sequence ID" value="SEG73341"/>
        <property type="gene ID" value="SAMN04489712_11098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="13066" checksum="E07E108BF7DC20BC" modified="2017-01-18" version="1">MTVPGYQRHYAPVRQRRTGMAVTSLVLGLVGLPTLLLCGLGLPLAMAGLVLGVVAASRNTEGRGIALMGIGVSLVTLLVGALGLFWLLSNAAKCADPDRYPTDADRQHCIEREFPFARPQPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CK85</accession>
    <name>A0A1H6CK85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease of the drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73157">
        <property type="protein sequence ID" value="SEG73157"/>
        <property type="gene ID" value="SAMN04489712_11078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="164"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="30772" checksum="ADEF28F626C3D80B" modified="2017-01-18" version="1">MTRQITAPVRTSPEPAALAAVAVTVLAWASAFVAIRWVGRSYEPGALALGRLLVGSAALGALLAARRAWVAPNRREWGLLALCGVAWFAIYNVALNAAEQHVDAGTTAMLVNIGPILIAVFAGLLLGEGFPRWLLIGLAVAFTGAVLIGLGTTGGGEGGDADLLGVVLCLVAAVTYAIGVLCQKPVLRRLPALQVTWLACTIGAVTCLPYTPALVDDLGDAPVGATGGLVYLGLVPTALAFSTWAYALARMDAGRLGVTTYLVPPVTIVMAAVLLNEFPRLPALVGGVVCLAGVALSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLE7</accession>
    <name>A0A1H6CLE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73859">
        <property type="protein sequence ID" value="SEG73859"/>
        <property type="gene ID" value="SAMN04489712_110163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="95" mass="10935" checksum="0606D7521F00AEF6" modified="2017-01-18" version="1">MRRLSPYADSRCEHRSAEEPNRRMVRMSALREELHHLVDQLPDERLAPVLALVREGARPGRRAAAVAALERVRERMRDVPGVDEELDRLRDGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLF7</accession>
    <name>A0A1H6CLF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73869">
        <property type="protein sequence ID" value="SEG73869"/>
        <property type="gene ID" value="SAMN04489712_110164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG73869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="58" mass="6594" checksum="D265E18DD0766626" modified="2017-01-18" version="1">MADAYLVDTGVFLRWFVDQEGFEHAREIQQAFLDGTVLLETVDFARVEVAVSSARRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNK4</accession>
    <name>A0A1H6CNK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid/amide ABC transporter substrate-binding protein, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74185">
        <property type="protein sequence ID" value="SEG74185"/>
        <property type="gene ID" value="SAMN04489712_110197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="35"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="412" mass="44130" checksum="63501D4956AB8CCF" modified="2017-01-18" version="1">MKALGLSAAVATVGALLAGCGGGPGGGGGKISDGSVTLAVLNDQTAIYADLSGKNSVEAVKMAVADFTARYGDKAVTKDIKVISADHQNKPDIANSKAQELYDRQRADVILDVPSSAAALAVANQAKAKKKIFMDIGAATTELEGKQCNKYTFHYGYNTYMLANGTGSTVTKDGSKQWYIVYPDYAFGQDMNKSFTAAIQKAGGTVVKSDPAPFPNDNFSTFLLKAPGLNPKPQVLGTMQAGGDLVNLVKQYNEYKLQDKGIDLAVGLMFITDIHSLGPDALAGTKFTDPWYWNATPQNRAWADKFMAKTGKRPSFAHAANYSAATQYLEAVQRAGTDNSDDVVKALEGHKFNDVFADNAEIRAQDHLLLHDVELAQVKPAAEVKEPWDYEKILKTVPANEAFQPADGSCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNN5</accession>
    <name>A0A1H6CNN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74225">
        <property type="protein sequence ID" value="SEG74225"/>
        <property type="gene ID" value="SAMN04489712_110202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295070" evidence="1">
        <location>
            <begin position="34"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="326"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG74225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="418" mass="45723" checksum="147F2D847F105EFF" modified="2017-01-18" version="1">MAYGGRWRAVVPAAVLGLIAAGVGHFGTGTANAAVFAPVAGPVFNNPKGTTAQQYAIMRRIERDIATAPRGSVIRVAVYSITLDSFVNKLIAAHRRGVHVRVLMDRHAVNGDWRRLQSALGTRVNLKSSASSYAALCSGGCMDHYHKNGKAIGSLHSKIFLFSGGGKRVVTVSSANPTTRQAETAWNNSYTVVGNKSLYNAYVRNFNDMSRGALGSYDHGYYWTSGTNPKAYFWPKSNSGSDTILSMLKLVACSKTHPSRVRVAMFQWTDGRLPLARHLASMAARGCRVTVIYTKDSIDSSIRSTLAKSRIDVRDTTHGTRADGYARYYTHNKYLLIDGRYNGVNGRRIVMTGSANYTVNGVYHNDESNMRILGSSVYDAYLKNFNDQIAALPATTARKRAQGDLPTIPLHPEDLRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQJ7</accession>
    <name>A0A1H6CQJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75244">
        <property type="protein sequence ID" value="SEG75244"/>
        <property type="gene ID" value="SAMN04489712_1113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="158" mass="17352" checksum="72A087DB964BA745" modified="2017-01-18" version="1">MTTTAPLLVRPAEGQHVWHLGSMMRFIATGDQTEGHFWLADVTAPQGSSAPLHRHTREDETFMVADGELTVRVDDRTLKLGPGDIAYAPRHLPHDWRATSQQARFFVLGTPAGFEGYFFETGIPLPGPSALPPPGLEDEIPARTTLEAALVKYGCEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRT2</accession>
    <name>A0A1H6CRT2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75730">
        <property type="protein sequence ID" value="SEG75730"/>
        <property type="gene ID" value="SAMN04489712_11176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG75730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="587" mass="60506" checksum="A847D92841AA0021" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTD1</accession>
    <name>A0A1H6CTD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75825">
        <property type="protein sequence ID" value="SEG75825"/>
        <property type="gene ID" value="SAMN04489712_11188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="103" mass="11724" checksum="211A0755D77ACE52" modified="2017-01-18" version="1">MVMSVENDVWRLLADPLRARIVELLSREALCTCHLVAETGARQTNISNHLRVLREAGLVETEPCGRFTYYRLRPEPLRELADRCAALAEAARAAYDDDIRRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTX2</accession>
    <name>A0A1H6CTX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76541">
        <property type="protein sequence ID" value="SEG76541"/>
        <property type="gene ID" value="SAMN04489712_111176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045636">
        <property type="entry name" value="DUF6411"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19949">
        <property type="entry name" value="DUF6411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="8292" checksum="B26130A7CCC33CB8" modified="2017-01-18" version="1">MAIAGVIALCAVLLVLAFLLPRLSRHPQRGAQRAFGAGSRAGGSAPGGLGRLLSKPFRNSSRAVGRSGRAGRRARGRLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0H3</accession>
    <name>A0A1H6D0H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78881">
        <property type="protein sequence ID" value="SEG78881"/>
        <property type="gene ID" value="SAMN04489712_112137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295401" evidence="1">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="15717" checksum="5B820E3EACF57625" modified="2017-01-18" version="1">MKYGKRSTVLVLGVAATLPLSVTANAAPAGSPSSARACSPGTSYISNQGDIGLGVMFDWRGYGKIYAEGYYDKVLPVGQRTDCASGFGWPYADGYYVASGYCAEIRTTDSSGRWKYYSTVLAGQSWRPDLGRSFERWEVNQFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6W9</accession>
    <name>A0A1H6D6W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80296">
        <property type="protein sequence ID" value="SEG80296"/>
        <property type="gene ID" value="SAMN04489712_11357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="904"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG80296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="975" mass="102667" checksum="FF0505DF38391C85" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D921</accession>
    <name>A0A1H6D921_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_114127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81719">
        <property type="protein sequence ID" value="SEG81719"/>
        <property type="gene ID" value="SAMN04489712_114127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="93"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="798" mass="86360" checksum="5A4E744A499345B8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9N3</accession>
    <name>A0A1H6D9N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81533">
        <property type="protein sequence ID" value="SEG81533"/>
        <property type="gene ID" value="SAMN04489712_11479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="275"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="275"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="42265" checksum="F4FB4B2FA26AFC7F" modified="2017-01-18" version="1">MNTDSEPLAGFAVGVTAARRHEELAALLERRGARVVHAPAIRLVPLSDDAELLHATNVCLGERLDHVVVTTGIGFRAWLETADGWGLREELIDRLHKVRILARGPKARGAIRSAGLQEDWSPDSESCEEVLRHLLAEDLTGARIAVQLYGEPLPDFTGALRRAGAEVIEVPVYRWSRTDDSTPLRRLVGQAVAGTVDAITFTSAPAVTATLAVAAEDGLEEALLEALRTHAVAACVGPVTAQPLTERGVPTVQPERARIGALVRAIVSDLPRRRARLINVRGHALELRGHAVVLDGQLRPIAPAPMAILRALARRPGHVVSRAELCTVLPSRMITGGGLWARDGRPQADEHAVEMAVARLRRGLGRSGIIETVVKRGYRLACDPVRMEIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBW2</accession>
    <name>A0A1H6DBW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_115112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82947">
        <property type="protein sequence ID" value="SEG82947"/>
        <property type="gene ID" value="SAMN04489712_115112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGRP" evidence="4">
        <location>
            <begin position="32"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG82947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="27647" checksum="B1608E1925026268" modified="2017-01-18" version="1">MAVFPTGDEARAAGRDDTAGGRGAGGGGRGMPRVHTRRQWGAKPPRHRARVLDRAPDHIVVHHTATTNTKDYSKAQAYRLSRIVQRFHMRQLGWDDIGEQLTISRGGYVMEGRNRSLAAIRNGRHVVGAQTLGYNDSTIGIENEGNYSNAPVPVQLWASLVDTCVWLCYAYDLDPFQAIVGHRDFGSTECPGDVLYQRLPELRWVVARRLGVQGERVATPGHGDLHVPNQDSASRTVLRGVPDPPAQPDGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DD24</accession>
    <name>A0A1H6DD24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase, FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82615">
        <property type="protein sequence ID" value="SEG82615"/>
        <property type="gene ID" value="SAMN04489712_11550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="398" mass="41563" checksum="EF0239DB6B65474D" modified="2017-01-18" version="1">MTGNTDVVVVGGGYAGVMAANRLTQRDDVTVTLINPRPAFVERIRLHQLVGGSDDAVVDYREILAEGVRLVADTVTRIDTAGRGVALAGGGTVGYDYLIYAVGSGSADPRVPGAAEFAYPIATLEEAQRLRSVVAAVPATDAVTVVGAGPTGIETAAELAEQGRRVTLVCGGVLGPYLHPRGRRSVAKRLAKLGVTVLDGPGAKVTAVTRDAVRLHDGRTLPSAVTIWTAGFGVPDLAGRSGLSTDALGRLLTDETLTSVDDARIIAAGDAAAPSDLPFRMSCQAATRIGAHAADTVLNRIAGEQPASINLGFFGQCISLGRRAGIFQFAAKDDTAIRLYLGGRPGAKLKEFVCRHTVKHLADEARKPGSLTWVKDDKRRQALRAERGEAAATVERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFK3</accession>
    <name>A0A1H6DFK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative stress-induced transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_116125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84010">
        <property type="protein sequence ID" value="SEG84010"/>
        <property type="gene ID" value="SAMN04489712_116125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="137"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="20381" checksum="41F8111803BCC33D" modified="2017-01-18" version="1">MIFTHDTEHALGTVVDLVNTGPDDSGEDGLAGLTALRSFVERNRFSDVPELTDDDLARVRALRAAFRAVFDAPDVPSAVELINRIVGAVRTTPHLTDHDGYDWHVHFFAPGAPVAEHLAADGGMALAYVVAAGELDRLRTCEAPDCSRVLVDLSRNRCRRYCDSRTCGNRMHVAAYRARQREAAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGW5</accession>
    <name>A0A1H6DGW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83885">
        <property type="protein sequence ID" value="SEG83885"/>
        <property type="gene ID" value="SAMN04489712_11692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="28630" checksum="7DB6B53430142E72" modified="2017-01-18" version="1">MVERAGRVEGKVAIVTGAGSTPGPGIGTGKATAVVLAREGARVLLVDLHPERAAQTRAMIEAEGGTAEVFAADVTRAADCEAMVGAAVEAFGTVDILINNIGRASLGTVVDTTEEDWDRAFAINLRTAFLAAKYTVPVMAAKGAGSIVNIASISALRGDGTVAYSAAKGGLIAMTVDMAYSHGRQGIRVNAVAPGHITTPMVVSVSQPGPRAEFMNTLRSEAGLLGTPGDGWDVGWAAAFLAGDEARWITGVTLPVESGVLSVTPLMMAPHLRAVPDPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DH68</accession>
    <name>A0A1H6DH68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase CsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84521">
        <property type="protein sequence ID" value="SEG84521"/>
        <property type="gene ID" value="SAMN04489712_11718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="20"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="43175" checksum="BDA4B8FF8FB98118" modified="2017-01-18" version="1">MSDISRPLRVGVAGSYGGLNLGDEAILMCVLACLRQLRPSIEFTVFSRNAEHTRRMHGLARVVGWEGADRRQVQPSLQDLDLLVLGGGGLLHDGAARGFLRLVRLAQKSGIPTFGYALGAGPLTEAEDRRLVREAVHALNDLTVRDQESKLVLEEVEVDREIDVAADPALLLTPEPFTREMLEREGIPRDGHLVAMSVREPGRAAQNLDEHSYHELLGEVADFLVHRLDANVVFVPMERDDISHAHAVLSHMVAADRGHVLKRFYEPGQIAGLMRHFDLAVGMRLHFVMLAACAGVPVMPLPYAGKVFDFARIVGAPTLTGVARREAGPLIAEIDRLWDEREHCARLLRDRIAQLKRQAAVSCRRCGELIEQIEESRAALPVRGVPGTSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIJ8</accession>
    <name>A0A1H6DIJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator / MocR family aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84436">
        <property type="protein sequence ID" value="SEG84436"/>
        <property type="gene ID" value="SAMN04489712_1173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG84436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="477" mass="50831" checksum="F702DBB3F8462516" modified="2017-01-18" version="1">MPDSRVNSAQGVGFDLHLELSPTGPRRAAVAAALRAAVRSGRLAPGTRLPPYRSLAVDLGVARNTVADAYAELVAEGWLTARQGSGTRVAERVAAKPQRVPKKIPGRGATTHNLRQGQPDATSFPRAAWAAAVRRAVTAAPYDAFAPGDPQGRPELRRTLVEYLARARGVSASPDQIVVCAGFAHALRLLFGGGVLSGPLAVEPYSLPFHRGILADAGVRTIPLGLDAQGARTDQLASHPGTSSRRGAHAVLLTPAHQFPTGGPLHPARRAVAVDWARSRGGVVLEDDYDGEFRYDREPVGAVQGLDPDHVVYIGSLSKSLSPAIRLGWMVLPPHMADAVLAAKGLREAWTGVTDQLALAEFIESGHYDKHIRRMRQRYRARRNQLVATLAEHAPHIPVTGIAAGLHAVLRLPLGTEASTVEAATWMGVALDGLATFRHPDSPDPHRDGLVVGYAAPPEHRYRSALDALCRALPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIM5</accession>
    <name>A0A1H6DIM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_117128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85064">
        <property type="protein sequence ID" value="SEG85064"/>
        <property type="gene ID" value="SAMN04489712_117128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG85064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="223" mass="24636" checksum="C74820E786176E2D" modified="2017-01-18" version="1">MPPSAHSRTSPPAAARTRRGGRPTREEAARLDRAVRDCALRLFLEHGYEGTSMDAIARAAGTTKATLYKRFTSKEDVFSSVLEWAIMRSDWPRPEPEPPDLDDLEGALTAIAETALRRALDPAMVQLGRIAVTQAARFPEIARRTHAAGFFPRQPLVAELLRRHATTGAIVADDPEILAEHFLGMVAGMPARLASFGIVRDPDVQERHTRAAVRLFLRSLRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJS7</accession>
    <name>A0A1H6DJS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85667">
        <property type="protein sequence ID" value="SEG85667"/>
        <property type="gene ID" value="SAMN04489712_11856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="103" mass="10418" checksum="EE31B6190E5B67B1" modified="2017-01-18" version="1">MEPPRSGGQYGAGQAGQGGVEGSQPVGGGRSRPQRRLPAQQPVLECSFVLVQERDGDRRAVFTGIGAVGAITLGVVLNDDPVGAGRIAALTLIVSGIVLAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKZ6</accession>
    <name>A0A1H6DKZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">SAMN04489712_118113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85942">
        <property type="protein sequence ID" value="SEG85942"/>
        <property type="gene ID" value="SAMN04489712_118113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="14734" checksum="5B4768531CE592D7" modified="2017-01-18" version="1">MRAVVQRVSRASVTVDGAVVGAIEEPGLLALVGVTHGDTPEQARRLAGKLWGLRILDGEKSCSDVAAPLLVISQFTLYGDTRKGRRPSWIEAAPGPVAEPLVEAVVAELRGLGAQVQTGVFGADMKVALVNDGPITLVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMQ1</accession>
    <name>A0A1H6DMQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86421">
        <property type="protein sequence ID" value="SEG86421"/>
        <property type="gene ID" value="SAMN04489712_11979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296128" evidence="6">
        <location>
            <begin position="35"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="95"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG86421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="314" mass="31815" checksum="844BEA4C3BA8A333" modified="2017-01-18" version="1">MARALVVAMLRALLLFVAVSALVFGATELLPSDAAESRTGGRATAEQLAQMREGLGLDRPAWRRYLSWLAGLCHGDAGTSLVTDRPVAAMVAERLPATLTLTGCALAVAVPLMLLSAWLVGTASPRWRGPLAALATGVAAVPQVVFAAGLVVVFSAVLGWLPPVSLLPAEGSPLADPRPLVLPSLALAAPAAAFGAGLLGGAVADTVRRPHVRDAVARGLPRHRVAARHVAPFLLAPTARVLALTAGALLAAAAVVEMMFGYAGLGELLVSSIGTRDTPVVQAVAVLAAVAVLAGTAVADALGALTDPYARGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQ48</accession>
    <name>A0A1H6DQ48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_120118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87360">
        <property type="protein sequence ID" value="SEG87360"/>
        <property type="gene ID" value="SAMN04489712_120118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="433"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="521" mass="55845" checksum="3521946289D2B943" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT98</accession>
    <name>A0A1H6DT98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87983">
        <property type="protein sequence ID" value="SEG87983"/>
        <property type="gene ID" value="SAMN04489712_12151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="465" mass="51518" checksum="A62A8C8EE2CB9A00" modified="2017-01-18" version="1">MNESRQTSDLPGEPGRDINLHEPVDDLDTIDHMISRYFTPERLEWQWRQIVEAARTHGAGRSRGDASPAPASPPDTVLPCRAGASLAQSRDVGRAATSAVEAAESQAMSARDLRMASPGDREETRAVVVELQELLSRCPAGALGAEGSAVVLAAVAALAQALITDRDERAALRLIRAAFPHLEFLGRRHPAVLEVRRVRAEALSELGLYRRAEKLLRRLSEDEERVFGSGDPRTALLLLWTLVGSGRSQEAEGGFRSLEARLAQPRGTVTPMLWHLRCRYSWLLGQQGWVNESVRGYDDVIIDRSHELGADHADALDARHSKGKMLVLAEEGAQAVTLLQALADDRARVQGDRHPDTLETLKYLHLARVQMEPRDDRVLHHAINDLVQILRIQDERHGPVHPLSRDTTAWLHGLFRLQERARSRGHIPDLGRLPNTGEGQSRTIPLSRRSGTSPDARPAPEQVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTT8</accession>
    <name>A0A1H6DTT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88802">
        <property type="protein sequence ID" value="SEG88802"/>
        <property type="gene ID" value="SAMN04489712_12282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="25881" checksum="DFDAC4D72EC4C265" modified="2017-01-18" version="1">MDLQLDGRVALVTAASRGIGAAVADLLAAEGAHVAISAREPEAAPGRTPYPVDLADEAAVDRLVPDVVAAHGRLDALVVNTPGPKIMPFLETGAQDWALAYDQLVRPAVQLATAGARQMAGQEGGGSILFITSTWVKQPQAGGVLSASMRSLLSALAKQMSLELAPHGVRVNQLMPGATGTDRMRTIVAAKSAANGTSEEEEIGKVVSAIPLGRWAEPDEIARAAAYLVSPAASFVTGQAFAVDGGALRSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU55</accession>
    <name>A0A1H6DU55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske-type oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_122107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88922">
        <property type="protein sequence ID" value="SEG88922"/>
        <property type="gene ID" value="SAMN04489712_122107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG88922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="37954" checksum="8099B15777C2D5D8" modified="2017-01-18" version="1">MNVLDAYCRHMGGDLSRGEVKGDEIACPFHDWRWSGNGRCVRIPYSRRVPPRARTRSWMTLERNAQLYVWHDPQGGPPPPEVTIPEIAEVGSGEWTSFTWNRLLIEGSHCREIVDNVVDMAHFFYVHYSFPTYFKNVFEGHIASQYMNGRSRPDVDLGTHYSGEERVSVSQASYYGPSYMINPMRSTGGQGTLESILINCHYPVSPTSFVLQWGVMVKRPAGVSMQEAEQYAQGFAAGVEKGFLQDVQIWRNKAKIDNPLLCEEDGPVYQLRRWYEQFYVDVEDVTPQMTQRFECEIDTERAKEFWQKQVEENLAAGRTVGLEPETAEAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUY3</accession>
    <name>A0A1H6DUY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89078">
        <property type="protein sequence ID" value="SEG89078"/>
        <property type="gene ID" value="SAMN04489712_12316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="42"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="330" mass="35405" checksum="BB161D722DB66BD5" modified="2017-01-18" version="1">MDSIGKKLLDIAEQELGYTEKSGGYTKFGNWWFENVDDDPYFKTAPWCDMFLAWAADKAGVTEQAGQFAGTVDHAKWFRKNDAWGTEPEPGAIVFFDWNGSNDIDAIDHVGIVKKVDGKKIHTIEANVDGVHLKEKVRDSSMIVGYGYPAKVKVAAKPDKYVPKHAAPAPSPQEIAAAAPGEQGTARTQNQDAKPDGQFTVGGQDMVLGGLVAVAVVGTVALAAGRSAAAKVPSAPPVRVRKRGKHHRRPVALPADITPAQLEEAEAATTMMPAISAAVAAEAEDREFWGKIEHLKEDQELAFWDSLHAEVVTRSKANGSGHAVPSSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVH3</accession>
    <name>A0A1H6DVH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine/lysine/ornithine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89074">
        <property type="protein sequence ID" value="SEG89074"/>
        <property type="gene ID" value="SAMN04489712_12315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00615">
        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="3">
        <location>
            <begin position="7"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="4">
        <location>
            <begin position="417"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG89074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="487" mass="52557" checksum="410A4DF663068667" modified="2017-01-18" version="1">MDHSQAPVLDALAAYRRRGDVPFTPPGHKQARGADPRVREVLGEAVFHSDVLAMSGLDDRRSSHGVLAQAQRLMADAVHADQAFFSTCGSSLSVKSAMLAVAGPHEKLIVGRDAHKSVVSGLVLSGVRPIWVAPQWDPELHLAHPPTPECFEAAFAEHPDARGALVTSPTPYGTCADLRAIAEVCHRHGRPLIVDEAWGAHLPFHPDLPLWGMDAGADVCVTSVHKMGAGLEQGSVFHQQGDLVDPDVLKSREDLLGTTSPSVLIYAGLDGWRRQMVQRGQSLLDAAIKLAAETAERIGDIDGLHVNGPEFVGPDRAHDRDPLQVVIDLAGLGTSGYRAADWLREHHHINMHLADHRRISAQFTFADDAETAETLVTALRDLVGHASELADAPRARIPSPRQMRLELVHLPRDAFFGRTRQVPANQAVGEIAAEMLTPYPPGIPVVLPGERITGPVLDYLRSGVRAGMVIPDAADPSLDSVRIMIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWV1</accession>
    <name>A0A1H6DWV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89822">
        <property type="protein sequence ID" value="SEG89822"/>
        <property type="gene ID" value="SAMN04489712_12478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG89822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="215" mass="22628" checksum="A0751371D4031E39" modified="2017-01-18" version="1">MSPWGMPVDQQLLVAFAVTSVIAMVTPGPDMVFVLGCGMRGGPRAGLLATAGVATSEAVHIAVAAVGLAALFEAAPTAFTVVRIVGAAYLIYLGVQMIRHRNDVQDEGTVAGTGMSGRRAYLNGVLTNLLNPKMVTFTIAFLPQFVNPELGRVWLQFAILGAILIALEFLVDGTVGVLAGRIGGWLRRRQAARRRIDTATGGIFIGLGVKLAAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXF0</accession>
    <name>A0A1H6DXF0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">SAMN04489712_12453</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89754">
        <property type="protein sequence ID" value="SEG89754"/>
        <property type="gene ID" value="SAMN04489712_12453"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="298"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="412"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG89754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="427" mass="46172" checksum="7B60B902EDFA48A5" modified="2017-01-18" version="1">MPAIVLVGAQWGDEGKGKATDLLGGDVDYVVRYQGGNNAGHTVVIGDNSYALHLLPSGVLSPDVVPVIGNGVVIDPGVLLGEIDGLAERGVSCERLLISANAHLIMPHHRALDKVTERYLGKARIGTTGRGIGPAYADKINRMGIRVQDLFDPNILTQKLDLSLREKNQVLTKVYNRRRIETGPIVQEYVEYGERLRPYVADTTLILNKALEDDKVVLLEGAQGTLLDIDHGTYPFVTSSSPTAGGACAGSGIGPTKINKVIGILKAYTTRVGSGPFPTELLDEMGEYLRKTGGEYGVTTGRDRRCGWFDAVIARYATRVNGITDYFLTKLDVLSGLDQVPVCVAYDIDGVRHDEMPASQTEFHHAKPVLEYFDGWKEDISGAKTFEDLPPNAQAYVRAVEEMSGAQISAIGVGPGRDQTLSLRPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXK3</accession>
    <name>A0A1H6DXK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89305">
        <property type="protein sequence ID" value="SEG89305"/>
        <property type="gene ID" value="SAMN04489712_12363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="134"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG89305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="27427" checksum="4925F8BAC4F6DEBB" modified="2017-01-18" version="1">MAGKDRKKQLARQRYERQQARRAAEARRARRVQIIGAVVGVAVIAGGGAGIVALVGGDEEPKASADASPSPPPQDGAPKQEISLQRVDVKTAPGGGTAKCEYPKSDNDQDPPKDLGKPPATAAHTGTVKATIKTNLGDVGVELDAAKAPCTTNSFAFLAGKKFFDKTKCHRLTTSDSLKVLQCGDPTGTGMGGPGYSFANENTKGAKYTKGVLAMANSGPDTNGSQFFIVYGDSQLEPDYTIFGKISSGMDVIEKVANAGVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E095</accession>
    <name>A0A1H6E095_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90881">
        <property type="protein sequence ID" value="SEG90881"/>
        <property type="gene ID" value="SAMN04489712_12766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="188"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="209"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG90881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="797" mass="86830" checksum="8B6C57E1FF54942E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0U7</accession>
    <name>A0A1H6E0U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91041">
        <property type="protein sequence ID" value="SEG91041"/>
        <property type="gene ID" value="SAMN04489712_12821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="86" mass="9448" checksum="020746574251A976" modified="2017-01-18" version="1">MAHRTHRITAACPIHCLKAVLSAMAYNRLALAYEAPFDPPRTVGDVLKLAQDDKLNEITGLGPRRISEIEAALVFAGLPYRHTDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E247</accession>
    <name>A0A1H6E247_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91662">
        <property type="protein sequence ID" value="SEG91662"/>
        <property type="gene ID" value="SAMN04489712_13012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="110" mass="11727" checksum="ED44D6A452A50072" modified="2017-01-18" version="1">MSDWCGHRPWILSEAGLVPAPRRASPTWRQFLTAQASGILADFPALSVQDASIDLVAAVMPQLAHRPAEDAAAIVLGTGTGTGTGVRPRGRVPATSHRPEHGLTRDDLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3J9</accession>
    <name>A0A1H6E3J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol-2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91921">
        <property type="protein sequence ID" value="SEG91921"/>
        <property type="gene ID" value="SAMN04489712_13129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="141"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="33784" checksum="0A67192FA3D20459" modified="2017-01-18" version="1">MSECRITHVRYVGLGVRSFDRQVGFYQDLWGLVAEQSESGVSYLAAAGSTDPYSLRLRKAGEDRVDVVSFAVPTAADVDWYAERLIARRVRMISGPASLDTAGGGYGMRFHDPDGRTVEIAAGLTPRMAREVAEREHVPTGLSHVVLNSPDLPATTRWYVEVLGFAITDYLEDVMVFLKSATDFHHCLALAQGPHVSLNHVAYETRGLDEYLRATGSMMRAGGDLVWGPGRHGPGDNTFAYFCDESGFVAEYTTALERIADFEAWAPRVWKRVPQESDQWGTACVRRPEPFVGRPDPGLWTPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3N7</accession>
    <name>A0A1H6E3N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92187">
        <property type="protein sequence ID" value="SEG92187"/>
        <property type="gene ID" value="SAMN04489712_13251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025359">
        <property type="entry name" value="DUF4263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14082">
        <property type="entry name" value="DUF4263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="567" mass="64270" checksum="D0199BA75920D9AB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4T9</accession>
    <name>A0A1H6E4T9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92700">
        <property type="protein sequence ID" value="SEG92700"/>
        <property type="gene ID" value="SAMN04489712_1355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG92700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="11031" checksum="AC91E29F98BE54FE" modified="2017-01-18" version="1">MALASDVPLLFAGSLACSMGIGMFAAVDQALLLDVLPERDTEAGRYTSIYNFAATIPQALAPLVAPLFLGVGVTAGEDKNYTLLYLVAAACTVLGGLIVLRIKSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E768</accession>
    <name>A0A1H6E768_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93658">
        <property type="protein sequence ID" value="SEG93658"/>
        <property type="gene ID" value="SAMN04489712_1406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG93658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="30625" checksum="7CA8E4F83F750930" modified="2017-01-18" version="1">MKKGDVAPASMIDRVVRVLDAFDGSAHLSLSQVVRRTGLPRSSVHRILDRLVAVRWLTREGNDYRLGIRMLELGSLVLQQNRLRDAAIPFMHQLATSSRTVVHLAVLDGTEIVYLEKIGGPPGADLPSRMGGRAPAYCTGVGKALLAYAGDEAVQKVIDGGLQARTRFTITNRGRLLSELQQVRERGAAFDREEAVRGIGCVAAAVRGPGAAVAALSVCGPIGQMNFTQLTPAVQQAAQRVWRAANARSSRNRLRGSEESRGGGWPPGALDAWATWPRLTDWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7H1</accession>
    <name>A0A1H6E7H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_14035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93778">
        <property type="protein sequence ID" value="SEG93778"/>
        <property type="gene ID" value="SAMN04489712_14035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG93778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="13236" checksum="3EB923A71A10C49B" modified="2017-01-18" version="1" fragment="single">RFMGVNQRHHSLAVVPAPHDGDPGLVHLMVEVDTLDAVGRALDNVTRLGFSISSTLGRHTNDKMISFYVRAPGGWDIEYGTDGMLVDETYYTAEEITADSYWGHDWSGSEPLAAFTPPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7Y6</accession>
    <name>A0A1H6E7Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93361">
        <property type="protein sequence ID" value="SEG93361"/>
        <property type="gene ID" value="SAMN04489712_13831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="183" mass="20085" checksum="D63033868D705015" modified="2017-01-18" version="1">MANGFRTRRSPHTKRPRTVLPHRSPGSGQEVSPDLNRTLEPPPAWPIPVPTTEQTRRRQAAEIRAQYPDAVVWYGKKAELWMAAPTGAAGLIYAPTAAGLAHQLGEHYKQFLQTSRPAPARPTQRRTPGGNQAGAVLRSMPPRPVASRTTAPPTRTGRGRHEARIPGRFRRTMVGLGLMARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9D9</accession>
    <name>A0A1H6E9D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose/arabinose dehydrogenase, beta-propeller fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94337">
        <property type="protein sequence ID" value="SEG94337"/>
        <property type="gene ID" value="SAMN04489712_14619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="479" mass="52514" checksum="74FD82EF853FA1B1" modified="2017-01-18" version="1">MSVRTAQIAARAVERLPTLVRPKVDPGDVVVPDGYAVEACVLGLSFPTGMGFADDGSLFVLEGGSTWPTRPYLPARILRFHPEKGRIEQFATEVLGGPRGVAYRDGAIYVSVKGGYFTHIDRYDLVTRERETVVDGLPNGGWHEPGGPVFGPDGLMYFAQGSVSQNGVALPQGFTVDLAKHPRAHDVPGQDVTLTGNDVWSRDPIAPFPFLTRTGAFKPFGEPSQPGEVVRGQLKCSSGLWRSRPDGSGLELLAWGLRNPYGMVFGEDGELYVSDNDYEEKGERAIAMDPDRLWRIGNVHRPHGSVETPEWYGFPDFAGDGLPVWHDKHRPTKGQAAEPLIENPPPMAGPAVYLAPPHSCMTKMDFCRSDEFGHRGLLFQCQWGTLAPLNSPRPEDLTHGFNVTCVDVKSSEAFPFMHNPQPGPASRHPGRGGIERPVDCKFSPDGQSLYVLDFGVVKVTEGYLLSYGHTGVLWRVTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9P9</accession>
    <name>A0A1H6E9P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93839">
        <property type="protein sequence ID" value="SEG93839"/>
        <property type="gene ID" value="SAMN04489712_1415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="465" mass="50286" checksum="921299E4FA63F01A" modified="2017-01-18" version="1">MSAETTPLAAMLRRAAMNPRQLAAEINKWLESRGLGDRRIDLTAPYSWVRQGYKPYDPIPSVAAAVLSERLGISITVDELWPGRRPHAMPALSAATGLSGYRTVDDAVGALEELSALSAGAHTEITPASGPDLTAAVHQGLSTTLQWRRQDTTRELVLQPQVDVIASHVTALRKLDDRHGGGVLSLRYITGQLRSVLDLIKAANYEPAIGHQLMTIVADLAQLVGWVHFDAGRQGAAERYLLLSEWVSWALGERGRAANAIGMLSYISAFSGHGSEAVNIASAAERNCPAVPVLQARVIGRKATACAASGDISGFRAASEKAQELLTCRAPGDRPSYLYYLEPEQLALETGQALVMLAERSTIGRKPLLREAVTLLTPLSEVGARPEYPRAALLHGAFLTKAHLLNGDLDAAVHSARASLTRLSEVQSIRGITHLKRLRPVFARRKRSEVVSSFLPEFDEALSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAP9</accession>
    <name>A0A1H6EAP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000044">
        <property type="protein sequence ID" value="SEG94189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94189">
        <property type="protein sequence ID" value="SEG94189"/>
        <property type="gene ID" value="SAMN04489712_1441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="84" mass="9375" checksum="F754DF8862CD5145" modified="2017-01-18" version="1" fragment="single">RRLGVTRSRAAVGTSADNAAAEAFNATLKRETLQGAHHWPDTRTARLAVFRWITRYNTRRRHSRLGHTSPIDYEKTTGSLTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAY8</accession>
    <name>A0A1H6EAY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94086">
        <property type="protein sequence ID" value="SEG94086"/>
        <property type="gene ID" value="SAMN04489712_1437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="29279" checksum="82F4AEE227348809" modified="2017-01-18" version="1">MNSRPEARPAAPTGGKPDVVAMLDTNGRPRHAPAPSEDTFSQPSPVKEMESTGIPRSSTRRQRLFASSLRIAHAQGTKGVAKSRGSRRSKTLTGRCTDLIARLRRHEVIPSPFDAEQFINRLQDWRGRRIRLEPISLERATPDLPCGALIETATTDYILYIPGATPLHREHIIVHEVAHMLFEHESGLTALELGSALFPGLDPRLVRQVLGRASYTTDEECEAETFASLLIGDARRTPPPPDATDPGSPVLDRVEVAWGRPSGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBA3</accession>
    <name>A0A1H6EBA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_14818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94543">
        <property type="protein sequence ID" value="SEG94543"/>
        <property type="gene ID" value="SAMN04489712_14818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG94543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="419" mass="42404" checksum="C5E984275B005B27" modified="2017-01-18" version="1">MNGRSQLPVLAATSACFLSIGLLIPVLPQYVTGPLAHGPGTVGVLIAVPSITAILARPFAGRMADEHGHRSAAVAGAAVLAVAALALLGTGSLSALLACRAVAGVGEAFAYVGLAAAGASAAEDTTDTSGRITRFSIAVYTGLLAGAPLGTIVLSSLDFEWVWLLSSATAAAAAAICLVLPSNATASADPATSAGAQTARAAGSGRRERSPLVHRAGLLPGVAYGASIWGYTAFNTYIPLYGRHIGERDVRTEYLVYGVVLLAVRILGHRVISRLPPRRTAVTSLAFTAAGLAGMLIAPTAPGLVGGTVLLAVGQALGLPAFLAMAVDAVPAGQRGSVLATVTGFFDVGFLTAALGLGLATRTLGLEAGFAVAAGAAAAPLLLFIPRRRAIPPPVPPFRTTTEERPCPDPTRRTFRRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EEF2</accession>
    <name>A0A1H6EEF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PRiA4b ORF-3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000072">
        <property type="protein sequence ID" value="SEG95175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95175">
        <property type="protein sequence ID" value="SEG95175"/>
        <property type="gene ID" value="SAMN04489712_1721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41878">
        <property type="entry name" value="PTHR41878"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG95175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="131" mass="14527" checksum="F1EA155EE2FB0EB5" modified="2017-01-18" version="1" fragment="single">ENYHLHEFGLGWDHEEPNENTVTLAQAAPKAGHRLGYVYDFGDCWEHVIEVEKTHRPAPRTAYPRVSAGARACPPEDCGGPPGYHDMLKALRARKGARYRQVKEWLNGPYDPAAFDKNAANAALAELATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S1R0</accession>
    <name>A0A1H5S1R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44563">
        <property type="protein sequence ID" value="SEF44563"/>
        <property type="gene ID" value="SAMN04489712_10146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="74"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF44563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="30409" checksum="802B30CF428A5F6D" modified="2017-01-18" version="1">MARPVIRLIGSRGRRAAGEAGEAGRDAERAHDRMPGRPRWWVELSLIALCYHAYSMVRNLVPHDHAASVGRAYEILRIEDALHIDIEYGVNRLFTTCSWLGVTANYYYATLHFAVTLGVLVWLYVRRPARYATYRWILVATTLTALIGFWSYPLAPPRMLPGYTDTVVAFNTWGLYDSSPVATISNQYAAMPSLHTAWSLWCALAILAVVRKVWVRILAVLYPVGTIVVIMGTANHFVLDAGGGMAVLLVGWMFGQGTVRVVGYGMQMVRSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S203</accession>
    <name>A0A1H5S203_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ATP:glutamine synthetase adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">ATase</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Glutamine synthetase adenylyl-L-tyrosine phosphorylase</fullName>
                <ecNumber evidence="3">2.7.7.89</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Adenylyl removase</fullName>
                <shortName evidence="3">AR</shortName>
                <shortName evidence="3">AT-N</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Glutamine synthetase adenylyl transferase</fullName>
                <ecNumber evidence="3">2.7.7.42</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Adenylyl transferase</fullName>
                <shortName evidence="3">AT</shortName>
                <shortName evidence="3">AT-C</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">glnE</name>
        <name evidence="7" type="ORF">SAMN04489712_10144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18589"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP</text>
            <dbReference type="Rhea" id="RHEA:43716"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.7.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GlnE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.89" evidence="3"/>
    <dbReference type="EC" id="2.7.7.42" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44510">
        <property type="protein sequence ID" value="SEF44510"/>
        <property type="gene ID" value="SAMN04489712_10144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047388">
        <property type="term" value="F:[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000820">
        <property type="term" value="P:regulation of glutamine family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00802">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnE" evidence="5">
        <location>
            <begin position="86"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="6">
        <location>
            <begin position="350"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="GlnE" evidence="5">
        <location>
            <begin position="597"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="6">
        <location>
            <begin position="877"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl removase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl transferase" evidence="3">
        <location>
            <begin position="504"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF44510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1023" mass="111040" checksum="65EC5D60DD72982D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S9B1</accession>
    <name>A0A1H5S9B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47196">
        <property type="protein sequence ID" value="SEF47196"/>
        <property type="gene ID" value="SAMN04489712_101124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF47196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="17800" checksum="67A1E51188D48BEA" modified="2017-01-18" version="1">MTGFAPDAASSAPQPADAPAGGREELAAAQRALVAALVAGGPLPPGFDAERVGAAARALLRKRAGEVARAWPVLAAAYGPQWAREFGRWASGRPTRGSWRDGWDFARAHRDSLPPAAVCELVLTEARWAYDGRDDPRPRRFGVRRIPGGLVLIAFGRVRTVRRTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SV59</accession>
    <name>A0A1H5SV59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL-like Lipase/Acylhydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54334">
        <property type="protein sequence ID" value="SEF54334"/>
        <property type="gene ID" value="SAMN04489712_101374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="88"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF54334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="37300" checksum="544F27C944E8D142" modified="2017-01-18" version="1">MAGPKQWPRGAQRGGRVRLGGRGAALALLLALLLVTAGSLVALPAVRCEVFGQGCHRPAPAPAATGPASTAPRPLTPVEAATRGAYVALGDSYSSGEGAYATAADLASDNRCHRTSLAYYHAVVEEFRFAGGSAFWACSGATTASVLKGRSGEPPQADRVDADTSLVTISVGGNDAGFSRVLGGCVVRLPWSRGCRQQGAEIAGRLAALRQSLTTVLDTITERAPRARVIVLGYPRIFAEVSGATGDNLTIGDQQWLNARARDLNEVIRQVAAERDHQIAATRGRGSVEFIDAYSAFSGHEIGSADPYVNGLRVNLSALAAEPGSFHPTAGGYRALGRLFVEQIRKGPGRPLNQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SWZ1</accession>
    <name>A0A1H5SWZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum-pterin binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55070">
        <property type="protein sequence ID" value="SEF55070"/>
        <property type="gene ID" value="SAMN04489712_101397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="63"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF55070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="132" mass="14236" checksum="6B97632F3AF28F11" modified="2017-01-18" version="1">MTTFRISEAAALLGVSADTVRRWVDSGRLPATRDGHGHRRVAGADLAAFVRAQARREEPGSRFSSARNRMRGIVTDVVRDTVMAQVELQAGPFRLVSLMSREAADELGLQVGVVAEAVVKSTTVVVELPEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T257</accession>
    <name>A0A1H5T257_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56855">
        <property type="protein sequence ID" value="SEF56855"/>
        <property type="gene ID" value="SAMN04489712_101452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF56855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="25485" checksum="B2B1055481C620AC" modified="2017-01-18" version="1">MTVRALSPATGVIVTGGASGIGAACARALAEAGRPVALWDLADATALAERIGAETGAAAVALTVDVTDAAAFPAAVERSRAALGTIGGLVHAAGIPGPAAVGDLDEARWDAVQNVNLRAQALLVQVLLEDLRDQAGSAVVGISSIEAFLGQMFIPAYCASKAGLLGLTRALAHHLATDGIRVNAVCPGYIDTPMLQGTAPPEMAAGFAAKSPFGRLGRPEEVARAVRFLLSDEASFITGTHLTVDGGATAVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TB34</accession>
    <name>A0A1H5TB34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60006">
        <property type="protein sequence ID" value="SEF60006"/>
        <property type="gene ID" value="SAMN04489712_101551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="192"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF60006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="365" mass="40281" checksum="CD55EE929AF4E1D8" modified="2017-01-18" version="1">MPAPQQGPAVPDGMNPAVVLDQRGRAELEFLAGMRAALTPLRARVRARIESSPQIAAWGGDDGADIESLREAVAAELDGTPEQDVIGAALRWNRQVLTPRAVDAFHARRDALEPLATAPDPDAIADRGDETVPRYWRYEFHGTRGGWDGHEHMGFVHHELVYRYLLVPAFGDIFAQRAAVADRAPREDYESICDLGCGTGQYTLKLAERYPAARITGVDLSMASLRYAQRRAADRGMDWRLVRAPAEDTGLPDGGHDLVTSFILLHEIPPHAIEKVFAEAFRLLRPGGDLVFSDVAPYRLRGPYQAWLDDWDAENGHEPWWRPAARIDLAAVAEAAGFTEVRQEALGPGSYPWVTLARRPQEGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TFU2</accession>
    <name>A0A1H5TFU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61685">
        <property type="protein sequence ID" value="SEF61685"/>
        <property type="gene ID" value="SAMN04489712_101603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="41"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF61685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="349" mass="38749" checksum="E729EEADF9158913" modified="2017-01-18" version="1">MKITGTVQHQAWQDKVLPPVEQVRPGLWSFPVPLPNNPLRYVLVYGLELPDGIALVDAGWDAPESWSALCGGLKTAGYEITDVRAVLVTHLHPDHYGLAGRIREASGAWVALHPADAGLLRERYQDFDGLIDAIGAQMKAHGVPEEEAGPLADASRTILPLVRHADPELLLEDGEQVPLPGWRLRTVWTPGHSPGHVCFLDPERRLLLSGDHVLPRITSAITVHPQQRHNPLADFFDSLDKVRALDVEEVLPAHEYRFAELAERVGALAAHHTARLDEIALLVIAAGDDGATAWDLARRLTWSRPWEQIQPFMRRTAMLETLAHLVMLATQHRVRMLEGPPARWCAMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TN76</accession>
    <name>A0A1H5TN76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64219">
        <property type="protein sequence ID" value="SEF64219"/>
        <property type="gene ID" value="SAMN04489712_101686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF64219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="22394" checksum="8B3342701D2620E0" modified="2017-01-18" version="1">MANDTETAATRWAGMPLAARRDERRARLVAAAFALFGTEGEAGVSVRAVCRAGRLHARYFYESFADTDQLLGAVYDKVAAELTERLRTALEATGDDLAERLRAGIHGVLEFSSADPRRGRVLFTEARANPVLAGRREATQTALMDAVLQQETRTHPAADPRLARVRAAMFTGAMVELAQQWLAGGLGDDLDIVVEHAAALLLAQHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TQF3</accession>
    <name>A0A1H5TQF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65016">
        <property type="protein sequence ID" value="SEF65016"/>
        <property type="gene ID" value="SAMN04489712_101709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF65016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="242" mass="25449" checksum="6B81361CF88775E5" modified="2017-01-18" version="1">MPDPTRTGILIVDDHALVRDGVREILETQEDMGVVGEASDSHSAVALAAETKPQVVLLDIGIPGDDAVTTVGRIRALSPGTAVVILSMFEGPYLLRSLLDAGIRGYLLKSATRQELVAAIRSVVADKARTVLSVSQESLLHLRGPAEDVLTPLEREILQLTAEALSNAQIAARLSLTEAAVKRHLGKIFGKLGAVSRIDAVNKAAAASLITVATVPPAPAAPEGGGRRGRRRGPAESERNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TX51</accession>
    <name>A0A1H5TX51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67415">
        <property type="protein sequence ID" value="SEF67415"/>
        <property type="gene ID" value="SAMN04489712_101780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF67415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="412" mass="45918" checksum="88E3EB02E2B3B913" modified="2017-01-18" version="1">MTVQETPAETPQSRGKCPVDLWSEEFNQNFWETLGHLQQNSSLGVHTQGSTPCYYATRYEDVFKVLRDAATYSSEGGVAILGGDNRAEPPKNESRFLPEDLDPPVHTEWRRFLDPLLTAKEVEKYQQTILDVTDELLDAVLPQGRFKVIADFLRPLQLKVVFREILHLPEDEIEAWMHWSHDLFVGETPEIAAAAFQSINQAAEDLVVKRTAEPLDNDLVSAICAVKEVGGREPTLAERTAVTVPLAIAGTESVGTLLGGILHHLATHPDDLVELVADPSLVPAAVEEGLRMFANVTALQRTVTRDTELAGVPLKPGDKVWTSYNGANRDGDRFPDPHTWNLHREDVRHLAFGVGPHRCLGSNHARLMMRLALERVIARMPRFTLAPDQTIARFSMPTRGIHEFIIEIPTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TYF4</accession>
    <name>A0A1H5TYF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted kinase, aminoglycoside phosphotransferase (APT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67799">
        <property type="protein sequence ID" value="SEF67799"/>
        <property type="gene ID" value="SAMN04489712_101793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="40"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF67799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="40410" checksum="CEEBEAEC8F2A8586" modified="2017-01-18" version="1">MTTYDTETAPVRPGEDLDWPRVEDYLRTRLPELTGEFSVLQFPNGSANLTYRIRFGDTRLVLRRPPFGRLAPGAHDMRREYRALSRLWRAYPRAPRALLFCDDHSVAGADFMVMEYRPGIVVWDAIPESMAALPDAGRRIGLAVIDALADLHRVDPDACGLGDLGRPDGFLARQVAGWRKRWELAATEGSDPLAAELGERLAAGLPESGPPAVLHNDFKIDNCQFAPGEPDTVVSVFDWDMATLGDPLVDLGTLLNYWPDPEFGDAGALADLHLSRLGLPSRREVVDRYAARSGRSVRDIDWYEAYGCFKTLVILQQLYARHLRGETTDERMARRGDHISVLAERGMSRLGQPVTRSAKGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U078</accession>
    <name>A0A1H5U078_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68475">
        <property type="protein sequence ID" value="SEF68475"/>
        <property type="gene ID" value="SAMN04489712_101818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="55"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF68475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="14617" checksum="EC7B31C0A5CBD562" modified="2017-01-18" version="1">MSEPEIPVDEVTAPWWEATRERRLTVQRCRACGRHQHYPRALCTGCGGTDLDFADVSGVGVVDAFTIVHRAPRPGPEVPYVVARVRLAEGPVLLTNLVGADPGSWRCDAPVRVSWRPLPDGRHLPVFAPADKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UVN4</accession>
    <name>A0A1H5UVN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="3" type="ORF">SAMN04489712_10250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79073">
        <property type="protein sequence ID" value="SEF79073"/>
        <property type="gene ID" value="SAMN04489712_10250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF79073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="12184" checksum="7D6F9BC458C50673" modified="2017-01-18" version="1">MSNERAAGGAAPGAASTGSAITRDEVAHLARLSRLALGEDELGHFAAQLDEIISAVARVQQVAAQDIPPTSHALPITNVFRPDEVRPSLAPEQALAEAPAAEEQRFRVPRILGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UWQ1</accession>
    <name>A0A1H5UWQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79592">
        <property type="protein sequence ID" value="SEF79592"/>
        <property type="gene ID" value="SAMN04489712_10271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF79592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="27475" checksum="9CB1E51BA5D18D5A" modified="2017-01-18" version="1">MRQEFRTALVTGASSGIGEAFAALLAARGTDLVLVARRDDLLDRLAETLARRHRVAVRVLAADLTDPDGLARVAEALRREPVDLLVNNAGYGAFGAFAEIPLEDQFRQIDLNVRAVVRLAHAALPGMLERGRGGVLNVASMSAFTPSPGSATYAATKAYVTSFSESLHAEVQGKGVHVTALCPGFTRTDETAGPNLIWLRRADVARAGLEAVAAGRALCVPGNQYKMVLPALRLAPRSLLRVAVNRAWQQAADTKIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V1C9</accession>
    <name>A0A1H5V1C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lanthionine synthetase C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80488">
        <property type="protein sequence ID" value="SEF80488"/>
        <property type="gene ID" value="SAMN04489712_102101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="224"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF80488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="865" mass="94420" checksum="8CF8CF7631215BC4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VE65</accession>
    <name>A0A1H5VE65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85118">
        <property type="protein sequence ID" value="SEF85118"/>
        <property type="gene ID" value="SAMN04489712_102267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF85118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="60" mass="7290" checksum="78749829E8B73365" modified="2017-01-18" version="1">MRFFRRTTGRRAPQERRRAPSFRELRARLRTEKAEARLLDTEVRIHQEAARIRNQIRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VWI4</accession>
    <name>A0A1H5VWI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zn-dependent protease (Includes SpoIVFB)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SAMN04489712_102482</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91346">
        <property type="protein sequence ID" value="SEF91346"/>
        <property type="gene ID" value="SAMN04489712_102482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEF91346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="28765" checksum="98C9B3E4DBC67FED" modified="2017-01-18" version="1">MGNVRPMRGRSAVRPSPVFLAILGATVLCGLIVWRYGPVTLNPATPERLAIFGFVIAAWVVSLCLHEFGHAYLAYRSGDHSVATSGYLTLNPAKYADVTLSFAIPVLFILLGGIGLPGGAVWIDRGAIPGRLRHSLVSAAGPLSNLAFAAVLAVVYTQFLDDQHGLFWSALAFLIFLQVTAALLNLLPIPGLDGFGIIEPYLPRRWVRKANEVGGYAFFALIALLWIPPINRAFFDLVYNVTDAMSVEQFPIALGHALFQFWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VZD6</accession>
    <name>A0A1H5VZD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92388">
        <property type="protein sequence ID" value="SEF92388"/>
        <property type="gene ID" value="SAMN04489712_102522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF92388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="554" mass="62118" checksum="23B8AA04649EB97C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W057</accession>
    <name>A0A1H5W057_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">SAMN04489712_102541</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92904">
        <property type="protein sequence ID" value="SEF92904"/>
        <property type="gene ID" value="SAMN04489712_102541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="459"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEF92904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="574" mass="62739" checksum="05A3F83FC7282E6E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W0Y1</accession>
    <name>A0A1H5W0Y1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="2">3-dehydroquinase</shortName>
            <ecNumber evidence="2">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Type I DHQase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Type I dehydroquinase</fullName>
            <shortName evidence="2">DHQ1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroD</name>
        <name evidence="3" type="ORF">SAMN04489712_102537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92791">
        <property type="protein sequence ID" value="SEF92791"/>
        <property type="gene ID" value="SAMN04489712_102537"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00214">
        <property type="entry name" value="AroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="3-dehydroquinate binding" evidence="2">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF92791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="27201" checksum="52037809344B72C3" modified="2017-01-18" version="1">MADRTIRTVVVDGVVIGEGSPKILVPITGDTPERLRAQADALTGRPVDVVEWRADHFGALADTAAVVAAARMLTERLGGKPLLFTCRTTTEGGEAEIDDEAYGELNIAVAESGTVGLVDVECERRRDVVERVLSAAHACGVFVIASNHDFAGTPAKEEIVGRLRAMQRLGADICKIAVMPHSAADVLTLLDATRTMHEEHADRPLITMSMGGLGVVSRLAGRVFGSAATFGMVGTPSAPGQIDVDDLHTALRLLEQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WBB3</accession>
    <name>A0A1H5WBB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96471">
        <property type="protein sequence ID" value="SEF96471"/>
        <property type="gene ID" value="SAMN04489712_102647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="62"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="257"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF96471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="338" mass="36544" checksum="E7035E29C971C30E" modified="2017-01-18" version="1">MNNPVELHKEEPGGAAPLPADTAEARDARQALTALRGEVAKAVVGQDAVVTGLVIALLCRGHVLLEGVPGTAKTLLVRTLSRTLDLDFKRVQFTPDLMPGDVTGSLVYDNRTAEFEFREGPVFTNLLLADEINRTPPKTQASLLEAMEERQVSVEGVPRPLPDPFVVCATQNPIEYEGTYPLPEAQLDRFLLKLTVPVPSREDEIAVLQRHAEGFDPRDLSQVRAVAGAGDLAAGRQAVRAIHVDPKVTGYVVDLCRATRQSPSLHLGVSPRGATALLATARAWAWLSGRDYVTPDDAKALARPTLRHRVQLRPEAELEGATPDGVLEGILNTVPVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WYN9</accession>
    <name>A0A1H5WYN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molecular chaperone GrpE (Heat shock protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04644">
        <property type="protein sequence ID" value="SEG04644"/>
        <property type="gene ID" value="SAMN04489712_10319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG04644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="260" mass="27622" checksum="0BC4409ADDA81666" modified="2017-01-18" version="1">MLLHVSSAQDPPSDEGPVTAGRNGATGPPEPDPPPERRPGAEARARTAGEPSRPADPTDPVGPDRPAAGPAEPAESAEPAGASRLAAELARLTVAVEREHERAAHREAVIDRLHEDVQTLRRGELQALFDPVRAVLYRLHDLTGRESRRWVDDPPDPGHAAALLAAVSEEIAEALARTGVERFATRPGDPFDPARHRPVSVETVEDPALDGTVVGVCADGFERAGRVVRKAEVRVGRPPSTGRDPAAGPAPLSRSNDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X016</accession>
    <name>A0A1H5X016_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA carboxylase, carboxyltransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05144">
        <property type="protein sequence ID" value="SEG05144"/>
        <property type="gene ID" value="SAMN04489712_10334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="358"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG05144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="607" mass="63335" checksum="2865420C41DB9DF1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X081</accession>
    <name>A0A1H5X081_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, Lrp family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04953">
        <property type="protein sequence ID" value="SEG04953"/>
        <property type="gene ID" value="SAMN04489712_10328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG04953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="162" mass="18172" checksum="41405E6524D254F3" modified="2017-01-18" version="1">MDELDAAIVQALQTDGRQTNRELAERLGIAPSTCLERVRSLRGRGVITGFHAEVDLAALGRPLQALINVRLQPKVREAVEGFREYMTGLPETLAVFVVSGGDDFIVQVAVRDTGHLRDFVVDHVSRYRNIADVRTSIIYDHIRKTPVEAFVPDARERPRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X424</accession>
    <name>A0A1H5X424_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-formylglutathione hydrolase FrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06036">
        <property type="protein sequence ID" value="SEG06036"/>
        <property type="gene ID" value="SAMN04489712_10364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG06036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="33664" checksum="6349031DB73E10E1" modified="2017-01-18" version="1">MMSAPDPEREPDDGYGIRADDGAVIVGTWFRAPRTLDLAIRSPVLNEVGRARLLLPRGWSPTARRTWPTLWLLHGGPATAGGTSGHTAWTSGTRIEHLTRDLDVLVVMPDGGRCGDHTDWWNHGHGGAPRWETFHLSELRQILDRGYRAGPERAVAGVSTGGRGALAYAARHHGLFRAAASFSGPLDLLRADPAGLDGADLVRLVAETGCPGVDWRRIWGDPVGQRAVWRRHNPYDLAVRLAGVRLYLSAGDGDPVEALARKGTGRLAGRLRRLGIPATVHLYEGPRSWDRWERELRAALPLLLAEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XBX4</accession>
    <name>A0A1H5XBX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08965">
        <property type="protein sequence ID" value="SEG08965"/>
        <property type="gene ID" value="SAMN04489712_103175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="120"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG08965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="425" mass="44819" checksum="EE7CD569A6CF6AC0" modified="2017-01-18" version="1">MREPRIAVNLAFFSLLGVVLAVWAVRSIISIDALERPFHVTADFATSPGLNSDLEVTHLGVRVGKVGAVRLRQGHVAVRLDLNRDARVPAGVGARVLRKSAVGEPYIELTQPSHPGTAVLKDGGHIPLARTAGTVDYQELFAGLSTTLRAVDPRDARTLVHEAATGLQGRGNSINDIIGDTHQLTRTLAANAGTLDALSVELTRLTATLSDHRYQLASGVNDLAVLTSSVRRSRADLDTVLEQGPGRLREANRLLRVARPGLGCLLTATGTQTRPLLTDANSAKIRHVLTMVPTLRALVGDITARDASGAYLRVTPVITLGGSQAAAEYTRPLPRPASPAVPLCSATEKTGKRAGASGKTPASARDTQRTTAGTADPTLSARPVNSTGDPSASSRWLPLVPPGIGVVVLLAVAARAVRLRVRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XEN5</accession>
    <name>A0A1H5XEN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09807">
        <property type="protein sequence ID" value="SEG09807"/>
        <property type="gene ID" value="SAMN04489712_103206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="248"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG09807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="433" mass="47237" checksum="1B9D9A30B4E6B637" modified="2017-01-18" version="1">MSETEAAEPDAESPRSAAEREITRQEAVRADAVPLLDPREGIPPVVVDATALERVVRSFAAGYGPVAVDAERASGYRYGQRAYLVQLRRQGSGTALIDPIACPDLSRLDAVLADAEMVLHAANQDLPCLAEVGLRPRRLFDTELAGRLLGHPKVGLGSMVENVLGFVLEKGHSAADWSTRPLPEDWLRYAALDVELLIELRDALHAELERAGKLEWALEEFAAVLSTPPKAPRPDPWRRTSGVHRVRSRRQLAIVREVWLARDRLARERDLSPGRVLPDSAIVQLALESPRTPAELLALPTMRGRGARRHQSAWLRAVTRAQGLPDSALPPPSQPGDGPPPTHRWAERDPQAAKRLSAARTVVAALADEHTMPAENLLQPDSVRRLAWSPPAEVSAATVGGALRALGARDWQVRLVATPLAKALLRLEAKGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XH18</accession>
    <name>A0A1H5XH18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11031">
        <property type="protein sequence ID" value="SEG11031"/>
        <property type="gene ID" value="SAMN04489712_103249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289426" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="36"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="148"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG11031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="42584" checksum="BC259A3C36E705F8" modified="2017-01-18" version="1">MRDSRRTRPTWRATVLTAGAGLLLAALPPHVPAAAAGTPSPRPSTSSSGTPSPETDAPSPDPEASTPPQAGTPPAEATTPPQASTPPPGTAAPPQGGGLRPVESDFVDIRKVPRTVRQVRTGRGGSRGTFTSRCGRNENGHFNSDNFIVAPGVVNGAHHTHDYVGNLSADGFSTDESLAAAGTTCRRGDKSTYFWPVMRLRGANDTGQNDQSAADLNIGRIQTPATVSLQFRGNPRSRVTAMPRFLRIITGDAKAVTNGPLNARAAWTCTGFTDRVVTDKYPLCPRGSRVARVLDFPSCWDGRNTDSANHRTHVVFPDRRTGRCPTGTRAVPQLRMTLTYSFTLRRSQIRNGLVYALDSFPEQSHSPLTDHADFVNVMPNSLMRRAVDCINRGRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XPR5</accession>
    <name>A0A1H5XPR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribulose bisphosphate carboxylase small subunit</fullName>
            <shortName evidence="3">RuBisCO small subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbbS</name>
        <name evidence="5" type="ORF">SAMN04489712_103348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexadecamer of 8 large and 8 small subunits.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RuBisCO small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13643">
        <property type="protein sequence ID" value="SEG13643"/>
        <property type="gene ID" value="SAMN04489712_103348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03527">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00859">
        <property type="entry name" value="RuBisCO_S_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024681">
        <property type="entry name" value="RuBisCO_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000894">
        <property type="entry name" value="RuBisCO_ssu_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036385">
        <property type="entry name" value="RuBisCO_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31262">
        <property type="entry name" value="PTHR31262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00101">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00961">
        <property type="entry name" value="RuBisCO_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55239">
        <property type="entry name" value="SSF55239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="2 3" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_small" evidence="4">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG13643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="16172" checksum="47370A2EBEA13356" modified="2017-01-18" version="1">MRITQGTFSYLPDLTDEEIAAQISYALGRGWPCSVEFTDDPHPRNSYWEMWGLPMFDLKDPAGVLYEINECRKAYPNHYIRLNAYDAGYGRQTTALSFIVQRPPSEPGFRIDRQETSDRRVRVSLHAYATDRPEGDRYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XRY4</accession>
    <name>A0A1H5XRY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14413">
        <property type="protein sequence ID" value="SEG14413"/>
        <property type="gene ID" value="SAMN04489712_103379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG14413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="119" mass="13225" checksum="4FA0F86958DCF1B2" modified="2017-01-18" version="1">MCSTRPKAVPLMPGRSPQDRERRVSLHGVDPCEEYLCELRSPLRTLGCPAELVRPEPGALVLRVSYPDRPLDSEDVVCAWTEGEWWFTWIGGHIIGPAEDLGGVAIAIYRTLRDGQVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XUY8</accession>
    <name>A0A1H5XUY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-methionine transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_103419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15473">
        <property type="protein sequence ID" value="SEG15473"/>
        <property type="gene ID" value="SAMN04489712_103419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG15473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="35938" checksum="E8DF0928F511B966" modified="2017-01-18" version="1">MIQIEKLRKTYRARGRTVTAVDGVDLRVREGEIFGVLGRSGAGKSTLLRCVNLLERPDSGRVVVDGRDLSTLSGAQLRAARQRIGMIHQHFGLLSSRTVAGNVAFPLEVMGVPRRERARRVAELLELVGLAEHAGAYPAQISGGQKQRVGIARALAGRPRVLLSDEATSALDPQTTGSILELLRGLNRELGLTILLITHEMEVVKRICDAAAIMRDGRLTESGPLAELLTRPGSELAAGLFPLPESGAVRPGTTVADVTFVGEAADRPFVSTLARTYAVDVNILGGAVEQVGDLRVGRLRIELPGDPDANAAQLAHLREAGLTVEVHGRDTALEGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YJG3</accession>
    <name>A0A1H5YJG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">X-Pro dipeptidyl-peptidase (S15 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23516">
        <property type="protein sequence ID" value="SEG23516"/>
        <property type="gene ID" value="SAMN04489712_10416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290602" evidence="1">
        <location>
            <begin position="28"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="302"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG23516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="494" mass="52802" checksum="B108274CFF5318D3" modified="2017-01-18" version="1">MPRSLVVSVAASLALAPLVLYVPAAHAADGVRTVQVRSFDGVRLVTNFFPAAGPAKGGRAPTVMLGHGFGGRGETDPDAGQVGPLRRAGYNVVTWNARGFGSGGRANLNYHRFEGRDSTALIDWIARQPEVLTDRPGDPRLGMAGGSYGGGIQLLTAGLDRRVDVIAPNVTWNSLTDSLYPSRVFKSGWASLLCLAGHTQGNRVAPQVSQGCVSGLASGTVPASTERWIDDHDLDPQVKRIRIPTLLLQGTIDTLFPLREAITNHRLLKAGGAPLKMVWYCGGHGECSTGTGPKDYIAGLTLTWFDRHLKGDRSVSTGPAFEYIDQTGTFRGGSYPLPALPSVKTTAPRARLLAVNDLAKSGTQTSATKATNGLTIRLRTFDGHSVGEPRLSFTYTGRASRTKTHVYAQLVDQTTGKVLGNQATPIPVTLDGRTRTVTHNLETIAWKLTRDSRIALQIIPNTALFDGQRALGTMTISKTSLTLPRVRPGTITAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YML3</accession>
    <name>A0A1H5YML3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25381">
        <property type="protein sequence ID" value="SEG25381"/>
        <property type="gene ID" value="SAMN04489712_10492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG25381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="29928" checksum="78680F7C25B936A9" modified="2017-01-18" version="1">MIADILVAGLVFGSLYGLVAVGFNILHRPTNVVNFAQGELIMIGAMLMAATPIGGLPWGIAAACVMAVVAIVTLAEERVAVTPVLRRSSHAVGWVITTLAFSLLLAEAAGRLWTDQPSTVAPPWPLSMRVEEVLGVRFSSYQVAVVVIAVAVVALLDVLDRSRLGTALRAVAADRDGARLRGIDPAALTRRSFLLGGALAGLTGVLAAPLLLASVTMGLGLLIKGFAALAVGGIGDNRGVLVAGWVLGVIEAAGAVFASPGSQSVVLFAAMLLILLIRPNGLRGLAVQRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZC0</accession>
    <name>A0A1H5YZC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1713 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012854759.1">
        <property type="nucleotide sequence ID" value="NZ_FNVO01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29140">
        <property type="protein sequence ID" value="SEG29140"/>
        <property type="gene ID" value="SAMN04489712_104254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="COX24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1713" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG29140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="32" mass="4017" checksum="3DFEB2A26371F5A9" modified="2017-01-18" version="1">MGSVIKKRRKRMAKKKHRKLLKKTRVQRRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZS1</accession>
    <name>A0A1H5YZS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Broad specificity phosphatase PhoE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29541">
        <property type="protein sequence ID" value="SEG29541"/>
        <property type="gene ID" value="SAMN04489712_104272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG29541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="23880" checksum="921A0ABB47BC70EC" modified="2017-01-18" version="1">MSEKTIVHLMRHGEVHNPEGILYGRLPGYRLSENGVLMAQEVAKWFADHDVTALFSSPLERALETAAPMSELFDLPVTVEERLIEAGNHFEGMTFGVGQGSLRRPAHWPFLINPVRPSWGEPYRQIAARMKAAVIAARDAARGHEAVCVSHQLPIWTLRRFAEHRRMWHHPRRRQCELASVTSLTFEGTRLVEVAYHEPAAGLVQRPTVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z4D1</accession>
    <name>A0A1H5Z4D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30495">
        <property type="protein sequence ID" value="SEG30495"/>
        <property type="gene ID" value="SAMN04489712_104310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG30495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="40" mass="4259" checksum="8869A0C3885E3BAC" modified="2017-01-18" version="1">MNRAIMPSDHGHQWYLSSNKNPNGYCGLGVSCPVGVAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZWP3</accession>
    <name>A0A1H5ZWP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Squalene synthase HpnC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40869">
        <property type="protein sequence ID" value="SEG40869"/>
        <property type="gene ID" value="SAMN04489712_10554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017827">
        <property type="entry name" value="HSQ_synthase_HpnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480:SF17">
        <property type="entry name" value="PTHR31480:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03464">
        <property type="entry name" value="HpnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG40869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="32231" checksum="8924EF44E1C0FBB9" modified="2017-01-18" version="1">MAVREPTWSVREHRRTLDELVRRENFPVATRLLPPRYRARLLAVYGFARLVDDIGDEAPPDERGTLLDLVERDLDVLYAGGRPQLPQLRELAGTVAACRIPAEPFHRLIRANRQDQVVHRYDTFERLREYCVLSANPVGHIVLHVFGAATAHRMAFADRICTALQLVEHCQDVGEDYRRGRVYLPAEDLRRFGCTEADLGRPVTPTRLRGLLAFQVDRARRLLNEGAPLIGTLSGWARIAVAGYVAGGRATLAAFERGGYDVLGGRLRAGRARLPAEWSRALGRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AE98</accession>
    <name>A0A1H6AE98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">SAMN04489712_105398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47063">
        <property type="protein sequence ID" value="SEG47063"/>
        <property type="gene ID" value="SAMN04489712_105398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG47063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="20810" checksum="F6C661F9BBA9EF89" modified="2017-01-18" version="1">METDLWLVIGLGNPGPGYAGNRHNAGFMVLDVLAGRAASRFRAHKSRADVVEGRLAGRRVVLAKPRSFMNESGGPVAGLRDFFKVPAERVVVVHDELDIPYGAVRLKQGGGAGGHNGLRSISRSLGTPDYLRVRFGVGRPPGRMDPAAFVLRDFSATERKELDLHVEVAADAVEMVLAEGLQAAQNAYHARTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AG71</accession>
    <name>A0A1H6AG71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46756">
        <property type="protein sequence ID" value="SEG46756"/>
        <property type="gene ID" value="SAMN04489712_105381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="37"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="27115" checksum="9D0353D5C22DE7C5" modified="2017-01-18" version="1">MDKQLGLGKSSAKGERGITKRLDALSRQTALRGDRLLDVGCGDGVYTVRLADGFSGVEAIDIQEDRLALFTERIKDTPLQRSITVRAMSAAELDYPDASFDLVTAIEVMEHVAELPRTLAEIHRVLRPGGRLCITTPNRWFPFETHGVLYRGRRYPSSRAPFVTWVRPVHRRFSDARTFTAAELRQHLAEAGLRTLSVDYMMPPFDRSGIGRRIRDVTDRIERSPLSFFGMTLIVTAEKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AHP3</accession>
    <name>A0A1H6AHP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="7">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmI</name>
        <name evidence="9" type="ORF">SAMN04489712_105426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47535">
        <property type="protein sequence ID" value="SEG47535"/>
        <property type="gene ID" value="SAMN04489712_105426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG47535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="28835" checksum="86680441C3343488" modified="2017-01-18" version="1">MLAAAPIGRVEDASARLRDALAEVEIIAAEDTRRLRRLAADLGVTLGARVVSYYDQNERGRAAELVGELLAGRDVLVVTDAGLPGVSDPGYRLVTAAVAEGVPVTVLPGPSAVTTALVISGLPSDRFCFEGFPPRRPGERSRALHRLAGEPRTMVFFEAPHRLAVTLAAMAEAFGADRPAAVCRELTKTYEEVRRGPLGELARWAEEGVRGEITVVVGGAPEETEAVTDPAELAAAVTALESGGTPRKAAIAEVARRNGLPKRVVYDAVVAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJV5</accession>
    <name>A0A1H6AJV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein, Cas6 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48811">
        <property type="protein sequence ID" value="SEG48811"/>
        <property type="gene ID" value="SAMN04489712_105498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="1">
        <location>
            <begin position="112"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG48811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="26420" checksum="AB0147268733C299" modified="2017-01-18" version="1">MPVSWGLELAGQPSRPLRWRFDVLHAIACRFFEGPDAVHEANEKCFSVRVGENGRRVVLTWLDDRAVPQVVIPGRLQVGSDEEIAVAAAERTAVGFEDIETGPVRTRWRLMVQTPALFRHHGLNYPLPDPQVMFAGLARRYRALRPDAAPDEEVVRQMGRRVATLRYRLRTERFSWHGRTDAGFVGQVELGLARSATTEAARAFTTLGIFAGLAGLGRGTTHGLGSTVVTSDDRQRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ALQ3</accession>
    <name>A0A1H6ALQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49017">
        <property type="protein sequence ID" value="SEG49017"/>
        <property type="gene ID" value="SAMN04489712_105510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG49017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="17452" checksum="730D3A95009645B7" modified="2017-01-18" version="1">MRVFADHGLTTASVQKVADQMGVSQPYVFRLFGSKRDFFLACVDEMEARIRRVLQQAAAQNPGDPLPAIRADFRALIADGVVTGLWLQACAAARSDEAVAARCRAMIGGILDEAEHRSTAGPRELRDTLALGALVVMLQALNVDLSEGSQAAIDSLRGVEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AN68</accession>
    <name>A0A1H6AN68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49517">
        <property type="protein sequence ID" value="SEG49517"/>
        <property type="gene ID" value="SAMN04489712_105536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG49517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="30190" checksum="38647557F93ECE86" modified="2017-01-18" version="1">MLSLLVGALVLSAIYALVGFAWVLLRRTNGILNLATGAQLALGAFIFNQYATSWGLPWPVVVLGTLATVVALGAVTHWLIFRKLAGQPEFALVVATLGLASALKGLSSLTWGTEARVMREPVEGRVVELLDGVSTTLYGIFGLVAALVVFAAAHAFFRYSTTGIRMRAAAENSVLASQGGIAVDWVYVLGWAIALTAAAIAGIMYAYQTTLSFHGVDALGLRGIAPALVGGLTSIKGVIPGALIIGLAETFGVKLFGGSAQDVAAWVVILVVLLIRPQGLFGEKQVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AY14</accession>
    <name>A0A1H6AY14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52975">
        <property type="protein sequence ID" value="SEG52975"/>
        <property type="gene ID" value="SAMN04489712_10665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="29373" checksum="F8F769AC53A18258" modified="2017-01-18" version="1">MEDAEKPRLLVNRWADAVGPGGGTDRDFCACLDPRAGRRQNPVRFHGERQDTSAPGWRRLLELIEEAADDGREVFQPLTELSPEERRQIITLPPTIAKLTAVKHLVLYGSNLVRVPPQIGAMTSLEEFSPYTSHRLHWFPYELTRCPKLVRSTVSTRSLYGNFKFRPPFPRLQPGPATLDGLDHTDLDPGVRGATAIHKCSVCDQPIGPSGVHQVWISLRVATDVLPLLVNACSSACVQALPQPADGYVPAPHTGGSEIVQPDPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYN9</accession>
    <name>A0A1H6AYN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53157">
        <property type="protein sequence ID" value="SEG53157"/>
        <property type="gene ID" value="SAMN04489712_10676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="15417" checksum="255332FE7C077667" modified="2017-01-18" version="1">MSLPAAVLVPAEPATPMYWRRTFPGDAAQVRAARTFAAFLLPGFPTLDDVLLTIDELAVNAIRHTRSGHFTVEVRHNPTGVTVSVTDQGAPTEPRVQPLTDPTALTESGRGLLTVTALATTWHWTGTPTSRTVHATFAAPAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B521</accession>
    <name>A0A1H6B521_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55943">
        <property type="protein sequence ID" value="SEG55943"/>
        <property type="gene ID" value="SAMN04489712_106272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="110" mass="11196" checksum="7DD3172A696B11C4" modified="2017-01-18" version="1">MTLTALLVLAGAGWLLAAAGLGRGPAETARTAALTAHALTPFGALLVNAILGYGLLYTLIALTAEWWALSLATLGRPRRLTDPASGGLTWLVAWLAGTAALTYGLAALIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BF80</accession>
    <name>A0A1H6BF80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione synthase/RimK-type ligase, ATP-grasp superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59429">
        <property type="protein sequence ID" value="SEG59429"/>
        <property type="gene ID" value="SAMN04489712_10768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="132"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG59429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="38672" checksum="E8650B1F07A0AF7F" modified="2017-01-18" version="1">MTLSDQQVLILTQEFDPTVDPVITTLTDRGVEVVRVDLSYFPRRLTFTTSDFEERRRYLRHGDREADLDRLSAVWYRRPTAFDFGPDMPEPEQIFARKEAMQAIGGILRATDCLWVNRPDIDAIGELKPYQLEVAKRMGLRVPRTLLTNDPQEVAALLERADVPIVYKAQTGGVIHYPGAFPGGLLTSVVGEEIREHLDRVGHTMCMFQDYIEKAYEVRLTVIGDTYFPVTINSQDRDTTRVDWRGESGEQAVLPYGDYRPLPEEIVKRTQALLTELRAVYAAVDFIVTPEGEYVFLEVNPAGQFMWMQHDLGLPLGDHMADLLMRGGPFQRGEATQVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BH46</accession>
    <name>A0A1H6BH46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein TerZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59667">
        <property type="protein sequence ID" value="SEG59667"/>
        <property type="gene ID" value="SAMN04489712_10783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="20354" checksum="477DEF774F4EF906" modified="2017-01-18" version="1">MSISLHKGQKVSLAKPDGGTLGKVRMGLGWDAVVRRGLFGRRRQSIDLDASCLLFDPSGNLVDAVWFRQLRSKDGSVQHTGDNLTGAGQGDDESIDVDLVALPAGIAQLVFTVNSFTGQDFSQIAGAFCRLVDEATGQELARYDLSGSGPHTAQIMAKLTRDGRDWSMTAIGATATGRTFQHLLPAVSAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKA9</accession>
    <name>A0A1H6BKA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61123">
        <property type="protein sequence ID" value="SEG61123"/>
        <property type="gene ID" value="SAMN04489712_107186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG61123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="23738" checksum="B0AE18ACF1587C4C" modified="2017-01-18" version="1">MLIAAAVCPHPPMLVPELMGEAAPELDGLRAACAAALRRLRSADPDPIVVVGGADTTRAFGPDARGDLRPYGLDLQVGGAPGGPCLPLSLTIGAWLLHRLGGEGLDSGRVRYQAVASGASPGECARLGVELAGAGRRVGLLVMGDGSACRSQKAPGYLDERAAPYDAGVARALGRADAAALAALDPGLSGKLQVAGRAAWQVLAGAAGEGAFRAELLADEAPYGVGYLVADWLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BQ92</accession>
    <name>A0A1H6BQ92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62802">
        <property type="protein sequence ID" value="SEG62802"/>
        <property type="gene ID" value="SAMN04489712_107323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025327">
        <property type="entry name" value="DUF4233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14017">
        <property type="entry name" value="DUF4233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG62802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="115" mass="11768" checksum="FA690B8131B4E3F5" modified="2017-01-18" version="1">MSGQPGRPPKPTSLLAAVLASEAVVIGLAIPVAVTVQQVDARIAGPVCGGLAVLCLLLAGMVRRRWAVAAGSVLQVLMVAAGFMVGTMFFLGALFGALWVTAIWLGRKVENAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BV78</accession>
    <name>A0A1H6BV78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64614">
        <property type="protein sequence ID" value="SEG64614"/>
        <property type="gene ID" value="SAMN04489712_10839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="7437" checksum="C2B589E612A96C00" modified="2017-01-18" version="1">MDERTARLRDIAEETFGWERLRPGQREAMQELLDGHDVLLVSPTGSGKSAVYQVPARLDHGLFAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C0C8</accession>
    <name>A0A1H6C0C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transport and Golgi organisation 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66429">
        <property type="protein sequence ID" value="SEG66429"/>
        <property type="gene ID" value="SAMN04489712_108192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG66429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="28216" checksum="A3F401BA0D071689" modified="2017-01-18" version="1">MCTAVVGFDPSSPVPLLLAGVRDEFADRPWAPPGAHWPDRPALLGGRDLRAGGTWLAVDPDAPRVACVLNGRGRLAPEEGRASRGELPLRAAADGGLGDLDLARFDPFHLVCAGLGGALLWSWDGHELAERKLGPGLHMIVNTGLEGGPATSVDPWERESEVQMTERIAFFRPRLTAARRPEPRTGTTAGAWGEWLPLLDGGGLDRADRRALVLTRRYEAGLWGTSSVSLVALSPQGVRYDFTAAPGDPRAWTAVLPAAERGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C162</accession>
    <name>A0A1H6C162_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_108207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66603">
        <property type="protein sequence ID" value="SEG66603"/>
        <property type="gene ID" value="SAMN04489712_108207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG66603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="228" mass="24687" checksum="FB6851D0B2B19E5F" modified="2017-01-18" version="1">MTVRVLLVDDQPLLRTGFKLILEAEPDLTVVGEAGDGAAAVEMTRAMLPDVVLMDIRMPGMDGIEATRRIVREGAATHDPRVLILTTFDLDEYVIEAVRAGASGFLLKDSPPEDLVTAIRIVAAGDAIVAPSVTRRLLDKFASRLPAVRESTPAPGLETLTEREREVLRHVARGLSNAEIARELVVSETTVKTHVGNVLAKLGLRDRVQAVVYAYESGMSRPGQTDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C363</accession>
    <name>A0A1H6C363_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67137">
        <property type="protein sequence ID" value="SEG67137"/>
        <property type="gene ID" value="SAMN04489712_108257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG67137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="25886" checksum="341CB58548F44E7C" modified="2017-01-18" version="1">MTTLDWRAMRAPAREPAVGVGVQLVLLTVLAAGVGLRPEGWAAATGYAVILAVLLTCALSRSRTRSLGPADWVTLARAELVGGVTALVATAWVGKAVPVGLIVALATVALVLDGVDGQVARRTGTVSALGARFDMETDAFLVLVLSVFAARSLGVWVLAIGAMRYVFVAASWAAPWLRASLPPSFARKTVAATQGVILVVAIAGVTSRPVAAGLVGAALAALVWSFGRDVRWLWRGRGAAGARGRTSPGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDG1</accession>
    <name>A0A1H6CDG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p-aminobenzoate N-oxygenase AurF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70873">
        <property type="protein sequence ID" value="SEG70873"/>
        <property type="gene ID" value="SAMN04489712_109215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="42442" checksum="C0818ACBD1E62E62" modified="2017-01-18" version="1">MSSFDRYATTVPKDTWDVPMAGDARFTWEYDGGRDRLLALYQKGKDKQWDAQLRIDWDQEVDPYNVAGLPENFNPLFGSQIWEKMSEADRQEFGRHQGSWLFSQFLHGEQGALNVSARIVQSVPDLDSKFYAATQTMDEARHVELYAKFVHEKIGMYYPINQDLAKLLKESLDDSRWDLPYLGMQVLIEGLALAAFGLYRDMATNPLVKQLLAYVMQDEARHVAFGRLALKDYYAELTEKERAEREEFVVEGCYLMRDRFKGREIFETLDMPVKECMAYVDNSDMYTLYQSLLFSRIVPCVKDIGLWGDKVQAAYADMGVLENAKADLTALMKQDEEIAEKYDEQRHQQELAVRRQEVDEAIALGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CE17</accession>
    <name>A0A1H6CE17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized membrane protein YckC, RDD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_109250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71204">
        <property type="protein sequence ID" value="SEG71204"/>
        <property type="gene ID" value="SAMN04489712_109250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="95"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG71204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="25664" checksum="AB3E9C26A25B34D1" modified="2017-01-18" version="1">MGNPYDPYGQQQPGYGQQQPGYGQQQPGYGQQQPGYGQQPGYGQQQPGYGQQQPGYGQQQPGYGQQQPGYGQQPGYPQQAEVHHHHYGTSHGSLAEWGSRVGAYLIDALVIGVPTGVLYVIGAICVGAGAPDPYTGDGGSGALAGLGVIFFLLAAALGLAAGLWLIHQEGTTGQTIGKRQMGIKLIGEHSGQPIGFGSAFVRKLAHFLDSFACYIGYFWPLFDDKKQTFADKVMNTLVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CI02</accession>
    <name>A0A1H6CI02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72630">
        <property type="protein sequence ID" value="SEG72630"/>
        <property type="gene ID" value="SAMN04489712_11021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG72630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="57" mass="6232" checksum="15BCB6446889F00A" modified="2017-01-18" version="1">MRRRLVRWVIVAALIVVAGALPVGGPQRMELRDVPEALSFFMKARPGGSEAAADRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIQ0</accession>
    <name>A0A1H6CIQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72854">
        <property type="protein sequence ID" value="SEG72854"/>
        <property type="gene ID" value="SAMN04489712_11042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="2">
        <location>
            <begin position="191"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG72854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="484" mass="53524" checksum="398F17F6F56230E7" modified="2017-01-18" version="1">MVAKTPMAAKKVTDSVQETVHKSEETVRKSPLGRLAGELPTDRLKGEMENLVGALAARALDSMIDRAEGTADRLIEYAEKGGGPGLMSALTGAPARGDGKAGSPVRSLLGSGLGAVGGSVKDALGGTLKDALGGKLGGGGEGDGRGGGLLGKVKGGAVKGALGGAIKGLFKGLRGKSGKLKVTNIIETIDVGVPVRLAYDQWTSFPQWPSFTKKVENVDRVADDKLAWKAQIFWSHRDWESTIIEQVPDRRIVWRSKGAKGHVDGAVTFHEIGPELTRILLVLEYHPRGLFEHTGNLWRAQGRRARLEFKHFRRHVMTNTILHPEDVDGWRGVIHDGEVVKDHETAVREEEEREEREERAGAEEREEREERAGAEERPSAARAEPAERRRPEAAEEEPEEEEEFEEEEPEAEAEEEEEPEAEEEEPEEEPEEREEPEEREPRGAREEEEEEMRPRRVRRPVIRRGGRPVGTAGERRIRRGRGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJ14</accession>
    <name>A0A1H6CJ14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72912">
        <property type="protein sequence ID" value="SEG72912"/>
        <property type="gene ID" value="SAMN04489712_11049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG72912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="83" mass="8745" checksum="A0DFC85994EA80B7" modified="2017-01-18" version="1">MTVGYSRGRELAAEGRLPAERASLVDLLDRLLAGGVVLQGDLTLSIADIDLVRISLRVLIASVGEGGTVGLPPSRPERPGWQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CPK2</accession>
    <name>A0A1H6CPK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74555">
        <property type="protein sequence ID" value="SEG74555"/>
        <property type="gene ID" value="SAMN04489712_110241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295125" evidence="1">
        <location>
            <begin position="30"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="42"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG74555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="33334" checksum="626A2FD7566C5770" modified="2017-01-18" version="1">MLRTFLIGVTAVAVTVVSACSVSTGPAGSSSADKPAGDQVVIGFSQVTQQSPFYVQLKNGAQQAADKAGAKLLFADANGDVTKQNNDIQDLITRGVDVLLINPVDPKGVAAGIAAAKAADIPVITVDRPVPSGAASHVGRDNVKMGELVGERVAQALGDAGGKVIEIQGDAGGAVARDRSKGFHQGVAGNSKIKIVQGPYCDYLRAKAVTAMQDLLQANPDVKAVYAHNDDMAMGALQVLRENRRTDVKVAGVDGLMEAVKAMPDGQYVATALNDPIGEGELAAQTAIKAARGEQVQASIDAGTALVGPADATKYVGDTVFAQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSE1</accession>
    <name>A0A1H6CSE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75884">
        <property type="protein sequence ID" value="SEG75884"/>
        <property type="gene ID" value="SAMN04489712_11194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="332" mass="37808" checksum="5DE9B90F32C288A2" modified="2017-01-18" version="1">MAAPLTPLALRNAITEALWANVKSYELAEVCEHLGLEPQRPNEDPHSSKRSYVNARLLGMDLAHLAEIARKVDEQFGDEDLAKVLARLGAKGVAGELKNLIFAADGPKPKIVLRDAVNNVIEIVENAQYCLVYDRPLTERGLTWQELVDWWIATRQPSSGDERRHARDLYERLWRSMAGNGPEQVLFRTYCERYARPGGFELPALIPQVYLHYDPYTRRHYPDRQGPLQRQRMDFLLLMPHRARVVIEIDGRLHYADEDGRADPQRYAAMMAEDRALKLSGYEVYRFGAAEFTRPQDAQALLAAFFDDLLTRHSCVPAADTTSHFGQVHTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTX6</accession>
    <name>A0A1H6CTX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_111160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76402">
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="BCTRLSENSOR"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <location>
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            <end position="56"/>
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        <location>
            <begin position="297"/>
            <end position="342"/>
        </location>
    </feature>
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        <location>
            <begin position="401"/>
            <end position="618"/>
        </location>
    </feature>
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        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG76402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="618" mass="66501" checksum="E3A41C102FF18DC8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CU63</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">SAMN04489712_111170</name>
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                <person name="Submissions S."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 43163</strain>
        </source>
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    </dbReference>
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            <dbReference type="EMBL" id="SEG76492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="41" mass="4425" checksum="47F6858148FCAB3B" modified="2017-01-18" version="1">MAEGLAVAVRAHLLDMAGDGRAARAQDELAVRRTLSIPERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUH3</accession>
    <name>A0A1H6CUH3_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">SAMN04489712_111165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="189"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        <location>
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            <end position="225"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG76447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="42972" checksum="482F3ABA3F68172D" modified="2017-01-18" version="1">MGMKPRGGRPTAHTVHLGAATLLRVSAEGLGTALVLIVQARTGQAATAGFLQTAMMLPYVLVGPVAGHALDRTPRPRSLVLTMAACYVLAAGLLLAAAGRVPMLIALLVAAVVGCAEPIVVALTGLLPRFVPPGRLTWAYGLEAATYNVAAIAGPGLAAVLAAAGAGYAGAAVVGSAVLGLLLLPLLAVPPPDAVPDAAHPGPALPDDDPLDGDPPVRAAGVERPGSGRAPVFDVITGGLVVLVANRTLRAVTVATTMAFLGMGGIAVTAVLFAEHIGERASAGGQLIAAFAVGSLIGSLAAARWLSARWAEWVLVGGMVAFGTALAAIAWAPSLPWALAGFVIAGICDGPVFAATLTVRQREAPADRLGQVNTTGGSLKIGSAALGAALTGVLAGQVGATGLLLGMAALQLLGAVLGTLLLIFRRRSGAGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV17</accession>
    <name>A0A1H6CV17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76698">
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        <property type="gene ID" value="SAMN04489712_111195"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG76698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="29657" checksum="296E083ED37C7DBD" modified="2017-01-18" version="1">MAEPIPAEGRAPLLVATDLDGTVVRSDGTISARTVAALARVEQAGATLVMVTGRPPRWMRDIATAVDHHGIAICANGAVLYDLHTETVLRTRLIEAEVIAEAVERLRTAVPELRFAVEYADGFVFEARYNLGRWDAEALGGRPVDGRTLVSRGGTKLLAFHPSADPDRLAEQVHTSVGDLVTVTHSSGRGLMEMSAQGVTKASALAELCAERGVAAADVVAFGDMPNDLPMLTWAGTSYGVANGHPDVLSAVTHTIARNDDDGVAQTLERLFPASDIATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZU3</accession>
    <name>A0A1H6CZU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78095">
        <property type="protein sequence ID" value="SEG78095"/>
        <property type="gene ID" value="SAMN04489712_11227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="41" mass="4386" checksum="5769FE317B8C4919" modified="2017-01-18" version="1">MSSVPFPTIAPARRFLLVASGRRLALLRPHEQPVPAPAAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D056</accession>
    <name>A0A1H6D056_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Transglutaminase-like superfamily protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">SAMN04489712_112127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78809">
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        <property type="gene ID" value="SAMN04489712_112127"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG78809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="15475" checksum="4B8E1ECE6D0CFE61" modified="2017-01-18" version="1">MSERVLIETGVAPPWYQWPAALCAVGIARVLAKLPPRRLRRALEFARRGARPATRQDALRARNAVVAVSMRCKGQWCLQRSIATALLCRMRGCWPDWCTGVRTQPFGAHAWVAVDGEPINENIKDIRSFHVVMTVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1X7</accession>
    <name>A0A1H6D1X7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_112125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78795">
        <property type="protein sequence ID" value="SEG78795"/>
        <property type="gene ID" value="SAMN04489712_112125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="36"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG78795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="31175" checksum="9879E61AD88B0DDD" modified="2017-01-18" version="1">MMLSDVGSPRQPPSGAFPNRMIPPQIRRQAGHELRAVRVLWQREVIRVLRNRSQAVLMLVNPVLFLLVLGTGLGAMIDSAAEGVDYRTYIFPGVLLMAVQMPALSAGASIVQDREIGFLRSMLVAPVGRGTLLVGKCLGGATAATIQSGLLLALAGLSGLPYDSGLLMLLLGELALIALMLTMVGMLAASFIKRTETFQAVLGLALMPLFFTSGAMFSVRGLPDWLSVLTLVNPLTYAVDALRRTVALELPAGRISSPSWAGWTPSIALELLIMVLFSLAALCFAARRFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6T1</accession>
    <name>A0A1H6D6T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80804">
        <property type="protein sequence ID" value="SEG80804"/>
        <property type="gene ID" value="SAMN04489712_113155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="685"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="2258" mass="241050" checksum="A999F623E1BF6379" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7F8</accession>
    <name>A0A1H6D7F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized membrane protein YccF, DUF307 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80665">
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        <property type="gene ID" value="SAMN04489712_113126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13977" checksum="280249486A9A28DE" modified="2017-01-18" version="1">MRTLLNVLWLVLAGFWLALGYVAAGVICCILIITIPFGIASFRIANYVLWPFGRTTVHRPGAGTFSLLGNVIWIIVVGWWLALTHLVTGALLMLTIIGIPFGVANLKMIPISLMPLGREIVRTGQHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7S2</accession>
    <name>A0A1H6D7S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81467">
        <property type="protein sequence ID" value="SEG81467"/>
        <property type="gene ID" value="SAMN04489712_11463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG81467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="23362" checksum="CB46F584A05A7C8E" modified="2017-01-18" version="1">MATRRRIGAPDAKNRAVLLDAAERLMLEEGYAAVSSRRVARQAGLKPQLVHYYFRTMDELFLEVFRRRAEEGLREQARALAGDRPLRALWEFATQPEATGLTMEFAALANHRKSVRDEIARYAERFRAQEIQALTGVLERAGISADDCPPAAVAIFLTSLSRVVVMEKALGMSAGHDEAFAFVERRIHEIESGRQSVGAPSGRTGAPPPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D895</accession>
    <name>A0A1H6D895_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mycothiol maleylpyruvate isomerase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81499">
        <property type="protein sequence ID" value="SEG81499"/>
        <property type="gene ID" value="SAMN04489712_11471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="220" mass="24485" checksum="DBCB5D82271DDD9D" modified="2017-01-18" version="1">MECTPPDRHRLLESYQDGVRAIQGLAARVEDWSVPTPCAEWTALDLAGHLRCVAENQLEYLQDAPDSRLAKLFAQNAPSAVLIRQQARQNAAELAVLPAESGPERIMTFTVSAGAYADLVPDAWDRTHLIYRGTKYTVGDHVGATCVEWHLHAWDLARALGLDHRPRDPEVLVAAWHWGVPHLPLTGADPWRSVLGSSGRSPRWPAADRELGKRRITRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCC7</accession>
    <name>A0A1H6DCC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tRNA adenosine deaminase-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82844">
        <property type="protein sequence ID" value="SEG82844"/>
        <property type="gene ID" value="SAMN04489712_11594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023869">
        <property type="entry name" value="tRNA_Adeno_NH3ase_assoc_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03941">
        <property type="entry name" value="tRNA_deam_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15439" checksum="45F2A9B92EA3BE96" modified="2017-01-18" version="1">MSYFAVVFARTPQGWVGAEAALDEAEVVDDLTDLMREAAVETLGETVLLLAEADDEWFAIARIDGEGEPRVFLSAARDEGLAGLFHQFVGEVPEGEAGGDPDLLADLGVDAARLGELGERVLPGDALFEIAEQLGFGEEFDGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF52</accession>
    <name>A0A1H6DF52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83844">
        <property type="protein sequence ID" value="SEG83844"/>
        <property type="gene ID" value="SAMN04489712_11680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG83844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="608" mass="68895" checksum="2DD55B2AC60639C6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHP7</accession>
    <name>A0A1H6DHP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84751">
        <property type="protein sequence ID" value="SEG84751"/>
        <property type="gene ID" value="SAMN04489712_11762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG84751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="53" mass="5779" checksum="948EAFD34A90B454" modified="2017-01-18" version="1">MEQIAPLIAQVRAAGGLEPLEGALRDWRGRLSARGRTMLTGAAELEAYLRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIG6</accession>
    <name>A0A1H6DIG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lysine 5,6-aminomutase alpha subunit /D-lysine 5,6-aminomutase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_117103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84972">
        <property type="protein sequence ID" value="SEG84972"/>
        <property type="gene ID" value="SAMN04489712_117103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015130">
        <property type="entry name" value="Lys-AminoMut_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037086">
        <property type="entry name" value="Lys-AminoMut_asu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09043">
        <property type="entry name" value="Lys-AminoMut_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lys-AminoMut_A" evidence="1">
        <location>
            <begin position="4"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="527" mass="56959" checksum="2ACC552D1E6085AA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNS2</accession>
    <name>A0A1H6DNS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86413">
        <property type="protein sequence ID" value="SEG86413"/>
        <property type="gene ID" value="SAMN04489712_11977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="119"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_12" evidence="3">
        <location>
            <begin position="722"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="905" mass="96460" checksum="275C8BB727063484" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRN0</accession>
    <name>A0A1H6DRN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87961">
        <property type="protein sequence ID" value="SEG87961"/>
        <property type="gene ID" value="SAMN04489712_12145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1208" mass="127490" checksum="630056A0856888B8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRU4</accession>
    <name>A0A1H6DRU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87940">
        <property type="protein sequence ID" value="SEG87940"/>
        <property type="gene ID" value="SAMN04489712_12141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="6456" checksum="ADF875493C56A9A1" modified="2017-01-18" version="1">MPALIAGLLLGLLAGLIAGLILGLAVGLAVFFTIGLAAGLIAGILIGVVVGLAVGLLIGLLVGRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DV93</accession>
    <name>A0A1H6DV93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89180">
        <property type="protein sequence ID" value="SEG89180"/>
        <property type="gene ID" value="SAMN04489712_12337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="20817" checksum="C500802C4D664DCD" modified="2017-01-18" version="1">MKTRRRAPGRRSGWLRFLGYGGSTLLVLAAVAVLALPLLGGGRDAGASAGPQTTGDPRTAAGPQGAGGRQQPSAAGDPRRPSGQGDVPDPRQDPLGQAGGGDQGPEMPLPGGGARDYCPRGLGAVQYGMTGLTVTVQLRGAAFVQVEVHLQGLTSLKQTTQVKGGRPHTFVFRQATADRVERIQVRSMGTTVPQTCDLRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVF3</accession>
    <name>A0A1H6DVF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89240">
        <property type="protein sequence ID" value="SEG89240"/>
        <property type="gene ID" value="SAMN04489712_12348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021416">
        <property type="entry name" value="DUF3048_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11258">
        <property type="entry name" value="DUF3048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296292" evidence="2">
        <location>
            <begin position="36"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048" evidence="3">
        <location>
            <begin position="58"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048_C" evidence="4">
        <location>
            <begin position="212"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG89240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="334" mass="35859" checksum="5BC67A7F5BCE9E27" modified="2017-01-18" version="1">MRFATSRAAATLGICALGAGLTACSGDDPKPPAPAATPTPTPSALPYHPFDGGRDGLRNPVLAVKIENTRPALPQSGVRAADIVYVEQVEGGETRLMAVYSSKLPKRVGPVRSARISDLEILRQYGRPAFAFSGVNPEFKPQIRRAPIYEVSQETGGSAYYRHGPRPIPYNLYADPKDLLKKAPRAGLPRDIGFRFGPPPAGGKPTDGYTARWPAATMGFTWSAKEKRWLSTHGGRTNTAAEGGVLGGETIVIQYAKMTRSRFRDVLGAYTPIIHSVGSGRALVLRDGMSYDARWARPSADKGTTFTTADGKPMTFAPGQVWIVLVNDGKPVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DW75</accession>
    <name>A0A1H6DW75_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ORF">SAMN04489712_12395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89449">
        <property type="protein sequence ID" value="SEG89449"/>
        <property type="gene ID" value="SAMN04489712_12395"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023471856" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023471855" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="180"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG89449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="384" mass="39468" checksum="BAC6AA0E68695997" modified="2017-01-18" version="1">MSVTAPLGFRAAGVVAGLKNSDDRDLALVVNDGPSRAAAGVFTRNRVKAAPVLWSQQVLSGGRVRAVVLNSGGANACTGAAGFQDTHATAERVGTVLDDSAGEVAVCSTGLIGERLPMDRLLPAIDTAAAELSRDGGLAAADAIRTTDTVAKISFRRAEAGYTIGGMAKGAGMLAPSLATMLCVLTTDADLDAAVLDRALRAATTVTLDRLDADGCISTNDTVLLLASGAAGVTPDEAEFTALLTEVCADLTRQLLVDAEGASKAIAIEVVGAASDFDAVMVGRAIARNNLLKCAIHGEDPNWGRVLSAVGSTEAVFDPDQVNVAINGVWVCRNGSVGDDRDKVDLRPRDVTITVDLSAGPESATVWTTDLTAEYVHENSAYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX20</accession>
    <name>A0A1H6DX20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diadenosine tetraphosphate (Ap4A) hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89624">
        <property type="protein sequence ID" value="SEG89624"/>
        <property type="gene ID" value="SAMN04489712_1249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="28"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="16510" checksum="711DAF1B354F92E9" modified="2017-01-18" version="1">MSLYCLDNHRTPEQLEEMRRLEAAGICLFCPDGLRSHPTQRIIRETAHWHITPNAYPYKGTAVHLLLVPHEHVTDLADLSEPARLDFFQALQWVRNEYDLTYYGLGIRNGDCRYTGGTIAHVHVHLLVGDTTPDSPPVRFRFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY59</accession>
    <name>A0A1H6DY59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90099">
        <property type="protein sequence ID" value="SEG90099"/>
        <property type="gene ID" value="SAMN04489712_12538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="14063" checksum="E11869543C3E2AF9" modified="2017-01-18" version="1">MEMERTAVNPWAWSVELGYNQGEIVSGHIRTLYCAGQTAMSGDGKPQHAGDMAAQLALSLDNLEAVLGEAGMSLANLVRLNVYTTDVDRLFEHYGVLASRLGAAGVAPSTTMLGVTRLAIPDLMVELEGTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYC1</accession>
    <name>A0A1H6DYC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase, carboxyltransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90360">
        <property type="protein sequence ID" value="SEG90360"/>
        <property type="gene ID" value="SAMN04489712_12613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="275"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="528" mass="57144" checksum="CA9107A0FAD6DEC2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ13</accession>
    <name>A0A1H6DZ13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90369">
        <property type="protein sequence ID" value="SEG90369"/>
        <property type="gene ID" value="SAMN04489712_12616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG90369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="41239" checksum="918490BC25E7E520" modified="2017-01-18" version="1">MGSPHAAAVRRRTGRDGWPLLFVLSGNMLLDAVEVSVVLVALPAIGADLGLDLWSVQWLMSGFALGFAVFLLLGPRLTAAWGLRRSYLVAMLVFAAASLAGGLSTSMTLLVASRVVKGACAALTAPAGLALIGETFPSGPRQRRAVSVYSMFGAYGFSLGLVLSGVLVADDWHWTFLFPAPVALLLLAVGHRVIPDVKGQAPPVFGAALFRNGPLMRAVAGAGSLNGVYIGLLLLATFTMSGSLGWQAWQTALALLPACLPLAISVPFAGHLIQRFGTSRLIAAGALLAFAAQLLALALSGRDSYGGALLPSLLLVGAAFVVSFAALNMQATQSTAPALRRAAVPVYQTGVQIGSVVMLPLVAALLNAPGGQRSALLATSVLAALGLAVAATGLRTRPGAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E488</accession>
    <name>A0A1H6E488_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellobiose transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_13215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92079">
        <property type="protein sequence ID" value="SEG92079"/>
        <property type="gene ID" value="SAMN04489712_13215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG92079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="36676" checksum="4B9CB01DDCEDC8F6" modified="2017-01-18" version="1">MSAPVHVRSRPSPKAAPPPSGRAGGGGWSGRLSRWDIRFSPYLFISPYFLLFALFGLFPMGYTLWVAMHDWELIGSREFTGLENFRLVLTDPQFWNSVYNTAGMFVVATVPQLVMALLLANALNRRMRGQTLLRMGVLAPMVTSIAAVAIVFSQLFSRDFGLVNWVLGWFGVEGLDWAAQRWSAWLAISVMVDWRWTGYNALIYLAAMQSIPRDLYEAAAIDGASRRRQFWTITLPMLRPTIIFTAIISTIGGFQLFTEPLLFGNGDMAGGSLRQFQTVTMYMFENAFTRFDYGYASAVSWLLFLLILLGSLLNFLWLRRVGGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4B3</accession>
    <name>A0A1H6E4B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92109">
        <property type="protein sequence ID" value="SEG92109"/>
        <property type="gene ID" value="SAMN04489712_13227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="21433" checksum="47B4EBACA78691B4" modified="2017-01-18" version="1">MRKIPTIFVRDWDGDPKHVTSVRNPECAWVFAGEGIATRKYDGTCVMFDGERWWARREVKPGKATPAGFVLVEEDGETGKRVGWEPIAQSGFAKFHAEALAAADRPGEAPSVWAPGTYELCGPKINRNPERAETHVLIRHALAERVEVPSPTFDGICEVVRRLAAEAGAEGIVWHHPDGRMAKIKARDFPGNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4Y8</accession>
    <name>A0A1H6E4Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucanase, GH16 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92084">
        <property type="protein sequence ID" value="SEG92084"/>
        <property type="gene ID" value="SAMN04489712_13217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="92"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="395"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="527" mass="55549" checksum="21A2E159E3262F0A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6B9</accession>
    <name>A0A1H6E6B9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaA</name>
        <name evidence="9" type="ORF">SAMN04489712_1381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93260">
        <property type="protein sequence ID" value="SEG93260"/>
        <property type="gene ID" value="SAMN04489712_1381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0050">Antiport</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG93260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="42501" checksum="B0457B063CD7B18A" modified="2017-01-18" version="1">MQRPVAAIWPVHHTVRYSRNLAEALRTETIGGFVMLAATVAALAWANSPWRDAYESLRHQVVGPSWLSMDVAHWASGGLLAVFFYIAGLELREELTHGELRNPRNAALPVIAAFAGVIVPAVLFLAVSAGEAGALSGWAIPTATDIAFALAVLAVAFPSCPAPLRAFLLTLAVVDDLIAITIIALFYAHGLAPLWLSAGIALIALFGVLQARGVRSPWVYVPIALLAWYCVYRSGIHATVAGVALGMLTSPRETSDERRTSAEQADHVLRPLSAGVCVPLFAFTSAGVALSPSALGDAAADRVALGVFVGLLVGKFLGVFGGAWLAVRLGLARLGSQLDWRDIAGAAVLAGVGFTVSLLIGGLAYPDAAQSERVTTAVLVASLFASALATVVFRVRVRQRAAVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6H0</accession>
    <name>A0A1H6E6H0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_13810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93292">
        <property type="protein sequence ID" value="SEG93292"/>
        <property type="gene ID" value="SAMN04489712_13810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="PTHR12318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG93292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="284" mass="31198" checksum="6A0CDC01942C788A" modified="2017-01-18" version="1">MSMIKGLKLPAEMRERLEDMRAGRIDPVPVRDAATVVVLRDHPEHGLQAFMLRRVASMAFAPGAYVFPGGSVDPRDGEASIGWAGPSPRAWGEAFGADETVARELVCAAVRETFEETLVLLAGPTPGSVVDDTRGDAWEADRQALLDRSQSLAQFLDRRGLVLRADLLRPWAHWITPEVETRRYDTRFFVAAIPEGQRAGDVSTEADRVAWVRPADAVERARRGEWFLLPPTLATLAELADYATVADVLAAERTIVPHAPQAKIIDGEAYLVVPEDAAEHYPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7V0</accession>
    <name>A0A1H6E7V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93331">
        <property type="protein sequence ID" value="SEG93331"/>
        <property type="gene ID" value="SAMN04489712_13822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="17604" checksum="EBCCF02A279EA1C3" modified="2017-01-18" version="1">MTTGEKKDPSIGLAEIPGDFSATLGGDDGAVPVPWRASYAISLSVVDGVRLMYVIDHAALTPWAWRVPVDAVRRQAVARMALSAGVLSRGDDRPASSDGGYRWLRMTAFGRSGQRVLPVVGSDEDAALANAFHALIPASVWQLLAERRAEFLAGAASDGGTQRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8S5</accession>
    <name>A0A1H6E8S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93529">
        <property type="protein sequence ID" value="SEG93529"/>
        <property type="gene ID" value="SAMN04489712_13923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="257" mass="26123" checksum="F53DDCF0D535CCD4" modified="2017-01-18" version="1">MATTPAPDPLPLRGRRALVTGASRGLGAATARGLAAAGADVALLCRRRAEEAAGTARAIRELGRDCEVLLADVADWEACRAAVESAASRLGGLDIVVANAGVANPHVSLADTPVDRWRKIMGVNLDGPFHTVKAAAPWLTGSPHGSVVFVSSVGGLRAAPMQAAYGAAKAALGHLARSWAAELAPLGVRVNTVVPGLFRTDMTQLLRQARPDGGDGLVPLGRVGAPAELADAVVYLCSDAASYITGAELPVDGGMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E964</accession>
    <name>A0A1H6E964_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94290">
        <property type="protein sequence ID" value="SEG94290"/>
        <property type="gene ID" value="SAMN04489712_14516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="170" mass="18285" checksum="804A1D0E679BD18B" modified="2017-01-18" version="1" fragment="single">MWSGASRYALSHAAEHAAAAGRLDELLTDPEFLVHADPATLIPLLDEANGPEARRHAAVYRTSAHLHQQQEPDARRSILATDAARHRIPDLTATLRLPRPEPAWWPAWATASQIHRALRTTLDSATWVVAVACTTLEGRPVAVTGGHDGTVQAWDLTLGVPVGGPITGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E981</accession>
    <name>A0A1H6E981_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93405">
        <property type="protein sequence ID" value="SEG93405"/>
        <property type="gene ID" value="SAMN04489712_13845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="46" mass="5121" checksum="C4CE3BCF333F7820" modified="2017-01-18" version="1" fragment="single">MVPYAAMLDVPRPVVAYVARLLAAHRRRIGTPRGSRAPGPFRQAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9C1</accession>
    <name>A0A1H6E9C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94317">
        <property type="protein sequence ID" value="SEG94317"/>
        <property type="gene ID" value="SAMN04489712_1469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="21102" checksum="40881346A3361421" modified="2017-01-18" version="1">MVGRPPAERADAARNRRRILAAAAEILRARGVAGLSMDEVAHAAGVGVGTVYRRFGDRAGLVYAMIDDRERDFQAAFLQGPPPLGPGEEPARRLRAFLHALAERTEAQSDLLLMAEMDSADARFEGSYDLYHRHLVMLIRLLRPDADAAYLADALLAPFAANLFVHQRRGRGMSVERIRSGLDDLIAGLARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9C4</accession>
    <name>A0A1H6E9C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_13925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93536">
        <property type="protein sequence ID" value="SEG93536"/>
        <property type="gene ID" value="SAMN04489712_13925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="222"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="379"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="471"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="577"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG93536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="723" mass="75826" checksum="8DFBD8F2FA167016" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EDE3</accession>
    <name>A0A1H6EDE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000054">
        <property type="protein sequence ID" value="SEG94894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94894">
        <property type="protein sequence ID" value="SEG94894"/>
        <property type="gene ID" value="SAMN04489712_1546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="127" mass="14028" checksum="06155D7E604FCE52" modified="2017-01-18" version="1">MQIGELAERAGVSTRSLRYYEQQGLISARRAANGYREYEEADLRLVAEIRALLAAGFKLEDARPFVDCLRAGHELGVACPESVAVSRRKLAEIDAEIRVLVRRRAEVAAQLAQARPGCELFPSEGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S579</accession>
    <name>A0A1H5S579_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SAMN04489712_10159</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44967">
        <property type="protein sequence ID" value="SEF44967"/>
        <property type="gene ID" value="SAMN04489712_10159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="7"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="339"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SEF44967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="458" mass="47717" checksum="5DDB91C7E14DD6AC" modified="2017-01-18" version="1">MANGDPFDIVVLGGGSGGYACALRAAELGMTVALIERDTLGGTCLNRGCIPTKALLHAAEVADQAREAAAFGVRATFEGVDVPGVHAYKDKVVSTTVKGLTGLIKSKGITVVAGEGRLAGPTRVQVGDEVYEGRHIVLATGSAPRSLPGLDIDGERVISSDHALVLDRVPGSVIVLGGGVIGVEFASVWRSFGAEVTIVEALPHLLPLEEESSSKRLERAFRKRGIKFELGARFEGVQTTGDGVSVTLEGGRTLDAELLLVAVGRAPVSEGLGFEDAGVELERGFVKVDEYCRTCVPTISAVGDLIATPQLAHVGFAEGIGVAERLGGLSPAPIDYDGVPRIAYCDPEVASVGLTSAQATQRGYEISQVTYDLAGNPKSKILGTQGEVKVIAEKNGRVLGVHMVGARVGELITEGQLIYNWEALPSEVAQLIHPHPTQSEAVGEAHLALAGKPLHVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SAN2</accession>
    <name>A0A1H5SAN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="8" type="ORF">SAMN04489712_101134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47545">
        <property type="protein sequence ID" value="SEF47545"/>
        <property type="gene ID" value="SAMN04489712_101134"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="7">
        <location>
            <begin position="24"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF47545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="28380" checksum="87E19E87830BC523" modified="2017-01-18" version="1">MTTTDTTGMTGTTDAREHADPLVIAGREFGSRLIMGTGGAPSMRVLAEALAASGTELTTVAMRRVDPAARGSVLDVLRRLDIDVLPNTAGCFTAGEAVLTAKLAREALGTDWVKLEVIADEHTLLPDPIELVDAAEQLVDAGFTVLPYTNDDPVLARRLEQLGCAAVMPLGSPIGSGLGIRNPHNIELIVEQAQVPVILDAGLGTASDAALAMELGCDAVLLATAVTRAQSPAAMAAAMRHAVRAGRLARLAGRIPKRRHAQASSPWEGIGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SBF9</accession>
    <name>A0A1H5SBF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase AhpD family core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47845">
        <property type="protein sequence ID" value="SEF47845"/>
        <property type="gene ID" value="SAMN04489712_101143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="49"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF47845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="183" mass="20136" checksum="229C336B0BAD50A1" modified="2017-01-18" version="1">MPQQNPRMPPPLAPRLAPLEEGDWDDVLKGVVATAGPLNVFATLGRHRELFASWLEFSSMLLLRGTLSARVRELAILRTARNSRCAYEWAHHVPTGREAGLTDDEIVALGGALDAHAWAPQDWAVVAAADELHNTGTLSDAVWTLLARRLDERGLIELVMLIGHHRMLAYALNTLRVQPDAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SGT6</accession>
    <name>A0A1H5SGT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nicotinamide mononucleotide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49158">
        <property type="protein sequence ID" value="SEF49158"/>
        <property type="gene ID" value="SAMN04489712_101183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF49158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="23233" checksum="D6571654C2B2AA54" modified="2017-01-18" version="1">MSWVDAGFEVLGQKVLWTDLAGNAAALGTVALAIRKTIWTWPVQLAGSVLLLVASLNAGLTGNALKQVMFGVLAGYGWWKWSQGLRGRDLPVRPATGYERLVLLAVLAAGTALVAAFFQATGWSWAPLPDAYIFVGSAVATYAQGRALTDFWLVWIAVDLVGVPLAFASGLVVSGVVYGVFLVMVLVGFRDWLRQYRAHREEGTGGPARPGTKEAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SI53</accession>
    <name>A0A1H5SI53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49427">
        <property type="protein sequence ID" value="SEF49427"/>
        <property type="gene ID" value="SAMN04489712_101191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="21627" checksum="428FFB5EC7EE967C" modified="2017-01-18" version="1">MTEGSLAALVALGAFHGLNPGMGWLFAVARGLQERARARVLESLPAIAAGHAASVGVVAVLVSLTQSVVATRIVAIAGGAALACFGLWRLLSRRHFRWVGMRLSLWQLAGWSFLMSSVHGAGLMLLPVITASAPVAGHAHGLGHAQGSALMSGIFVTGVHTLAMFAVAGVIAVLVYEVVGLAVLRRAWLDLDRVWALALIGAGTAAVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SNG8</accession>
    <name>A0A1H5SNG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative spermidine/putrescine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51994">
        <property type="protein sequence ID" value="SEF51994"/>
        <property type="gene ID" value="SAMN04489712_101287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="82"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF51994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="299" mass="32108" checksum="4A58328448F86619" modified="2017-01-18" version="1">MAVLDEAPGAARPTAGPAAPGRAPRERGAARPAVLLLPALVLVLVFFAYPLATMLWRAFTEPETGWGNFTWFFTTQANIDVLVRTFTTALWVTVIALLLSYPYAYLMTVAGPRGRAALTLLVLVPFWTSLMVRTFAWMVILQDTGVLNRTLDLVGLGPVHLIRTQAGVIVGMVQLLMPFMVLPLYAVMSGIDRRYVQAARSLGARPLTAFAGIYLPLSLPGIAAGSLMVFVSALGFYITPALLGSPDDALISQQIFTQVNGLLQWGRGGAMGVVLLGMTLALLVLVALVTRRAGRKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SVD2</accession>
    <name>A0A1H5SVD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53888">
        <property type="protein sequence ID" value="SEF53888"/>
        <property type="gene ID" value="SAMN04489712_101359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="25"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF53888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="277" mass="29992" checksum="5D6C7A22D4D5806E" modified="2017-01-18" version="1">MSEEKPTSVASAEPAEAASIGAPLLELREITMRFGGVVAINGLSLEVREGEIFALIGPNGAGKTTVFNVITGVYRPTEGQVLLGEQRIDGQKRYKVTKLGIARTFQNVRLFHNMSALENVMVGADAHHRTGLAGAGLGLPWHRREEREGREKGRALLEFVGVGNRGGEMAKNLPYGDQRRLEIARALATDPKLLLLDEPAAGMNPAEKESLQELIRKIRDSGRTVLLIEHDMSLVMGISDRLAVLDFGQKIAEGLPAEIQNDPRVIEAYLGAPADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T2D4</accession>
    <name>A0A1H5T2D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56973">
        <property type="protein sequence ID" value="SEF56973"/>
        <property type="gene ID" value="SAMN04489712_101456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="31"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF56973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="37420" checksum="F41B7EB2795C1847" modified="2017-01-18" version="1">MNAHVVEDPSGLTPEWLSAALGAEVTAVSWERVGSGQIGACYRLTLEGGQGVPRRLVAKLAAEDPAARAFLGPAYRAEVSFYRDLAATVAARTPRCHYSALADDHTTFVLLLEDLSPAVQGDQIAGCTPGQAAGAVANLAGLHGPRWCDPTLLDLPWLSAVGEEDATTLGEVFGPAVDTFVERFADRLPAADVRTLRQVADRVAAWVVGRPERFGLVHGDYRLDNLLFAAPPEEGVTAVDWQTLSIGHPLRDLAFFLATGLRPEDRPVHERTLVETYHTALTRYGVDDYDLGECLEDYRFAAVQGPLITVLGCVYGTRTERGDTMFLTMTTRSCAAIRELGTLDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T6Z3</accession>
    <name>A0A1H5T6Z3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57881">
        <property type="protein sequence ID" value="SEF57881"/>
        <property type="gene ID" value="SAMN04489712_101486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF57881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="6935" checksum="9BD1C5CD2ED99B3B" modified="2017-01-18" version="1">MTAKYEHWRKSRHSDPNGDCVEVARAADGSIGVRDSKAESPSAILEFTRAEWAHLLTKLHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TAT2</accession>
    <name>A0A1H5TAT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59906">
        <property type="protein sequence ID" value="SEF59906"/>
        <property type="gene ID" value="SAMN04489712_101548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="181"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF59906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="352" mass="39025" checksum="991417B0EE9125D1" modified="2017-01-18" version="1">MDVPVAQRDRAGLEFLGSLQGYTGGVLQAAAAARYASLVPDPPPDLVGRRHSVRETLADYGPWLFDRLFTRYVAEEIYVRAIPAAERARADIESWLEVPEDAPGSLRLDPDLVPPAYFGAGFHLTTGGWDGHDLMGVVIHDLGYRYVLMPGGVGAARAGENLMDHRTQVAREAPRRDYRRVLEVGCGNGRFATVLSKEFPEAQYVGVELSRTQLEYARARCAHEGHSWELVHAAAEATGLPDASVDLVAIFTLFHETPPKATEDIVHEMFRVLEPGGDIVIGDIAPYDRNDAFRSAVLDWETENRGEPFMRSYLQLDLPGLLKQAGFTDVQAYGLGKGDYPWIVRGHKERQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TJI1</accession>
    <name>A0A1H5TJI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Release factor glutamine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62328">
        <property type="protein sequence ID" value="SEF62328"/>
        <property type="gene ID" value="SAMN04489712_101624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="13"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF62328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="23957" checksum="BC3862137DB0C91C" modified="2017-01-18" version="1">MLRLPGVYRPQGDTDLLTKALREAAVRPGSRVLDMCTGTGAVAVAAALGGAREVTAVDVSARAVLAARCNARLRGLPIRVLRGDLAAPVAGEEFDVITANPPYVPRHSGEPAQHSRARAWDAGPHGRIWLDRLCETAPSLLAPGGMLLIVHSGLCGVRATLDALRGQGLKAAVIARRHEPFGPVMNGRAAELEAAGLIRPGQRYEELVVIRADRIEERAEERAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TWD6</accession>
    <name>A0A1H5TWD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67155">
        <property type="protein sequence ID" value="SEF67155"/>
        <property type="gene ID" value="SAMN04489712_101772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="542"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF67155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="808" mass="89276" checksum="714D5C73D08CEFA6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U2U9</accession>
    <name>A0A1H5U2U9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68581">
        <property type="protein sequence ID" value="SEF68581"/>
        <property type="gene ID" value="SAMN04489712_101822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022017">
        <property type="entry name" value="DUF3598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12204">
        <property type="entry name" value="DUF3598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3598" evidence="1">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF68581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="158" mass="17991" checksum="F11AE8F7DA35BC29" modified="2017-01-18" version="1">MTIAEILQRTSGVWEGTYTVLDAEGELLERFASRQEGLMEGTDWTEKVVYLRDGSEPEVRYYRAVVDGDSVEFVDDEMWGTTLRAGGQAILFTFGWNARPQERIVEMSMADGDYRTRLWQHFENGALSRLTMVEERRLPGAEPERWYTPPAAGETASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UWV5</accession>
    <name>A0A1H5UWV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78697">
        <property type="protein sequence ID" value="SEF78697"/>
        <property type="gene ID" value="SAMN04489712_10233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF78697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="94" mass="10504" checksum="B4AFF4AFF5541DC1" modified="2017-01-18" version="1">MSKEISDNTGQSRYEIRVDGRLAGFAQYRQRNGAVVFTHTEVDDEYEGQGVGSALVRGALDDVRSRGAQVVPLCPFVKSYIERHPEYQDLVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UYE2</accession>
    <name>A0A1H5UYE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79994">
        <property type="protein sequence ID" value="SEF79994"/>
        <property type="gene ID" value="SAMN04489712_10286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009286665" evidence="2">
        <location>
            <begin position="28"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF79994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="129" mass="13173" checksum="AF0923F01274C537" modified="2017-01-18" version="1">MPSTRMLLVGAAAAAGLAGAVLTVLGAASSPAGLLTLFFLLTGPALATWPLLARLTPAARAIVSGTMTFVVNTTVAQVMLSLDLWSPRGGVAAVLAICLLLVALDVALTHRATGRPTPPAEEDDWLFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V1D9</accession>
    <name>A0A1H5V1D9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase</fullName>
            <ecNumber evidence="1">3.5.1.118</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtC</name>
        <name evidence="3" type="ORF">SAMN04489712_102122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide</text>
            <dbReference type="Rhea" id="RHEA:42684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="ChEBI" id="CHEBI:82706"/>
            <dbReference type="EC" id="3.5.1.118"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.118" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81046">
        <property type="protein sequence ID" value="SEF81046"/>
        <property type="gene ID" value="SAMN04489712_102122"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02036">
        <property type="entry name" value="EgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017808">
        <property type="entry name" value="EgtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032889">
        <property type="entry name" value="EgtC_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03442">
        <property type="entry name" value="TIGR03442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF81046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="26068" checksum="44E5F32764A94BF6" modified="2017-01-18" version="1">MCRHLGYLGPPRTLESLIFDGPHSLEVQSYAPRMTRGNLLNADGFGVGWFHQERAVRFRRAQPIWTDHSFREIAGAVTASCAVAAIRSATTRFPVEESCAQPFRAGARLFSHNGRVEDFDGVEGKLRELAGDLAAVPDARAPVDSALVFALAARRWREGAPLAEGLAAAVTTVAGLSAGSYNLLAADGTALAATTWGDSLFVRADPGRVLVSSEPLDDDPGWKKVPDRSVVLADRTDVRVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V8F8</accession>
    <name>A0A1H5V8F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polar amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_102181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82737">
        <property type="protein sequence ID" value="SEF82737"/>
        <property type="gene ID" value="SAMN04489712_102181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="77"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF82737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="29779" checksum="B3054AF9F14A9685" modified="2017-01-18" version="1">MTTSATTEPSGPARKTPGRTGLSPRQRRRISLGVQSTVLAAGLLLVVLLVDWPLVRETFLDFGATREMYPDLFTIALKNTVIYTLSAYAVGFSLGLVVALMRLSSLAVYRWLALVFVEIFRGLPALLTLMIVGYGLPIALGGPVPGGTVGAVAVGLGLVAAAYMAETFRAGIQAVPKGQLEAARSLGMSHTRAMFSIVIPQALRIVIPPLTNELVLLFKDSSLVSALGIAAAGVELTKMGSDFAINTADSTPFVVAGACYLIITVPLGILVRRLEARQAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VAY3</accession>
    <name>A0A1H5VAY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_102247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84542">
        <property type="protein sequence ID" value="SEF84542"/>
        <property type="gene ID" value="SAMN04489712_102247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="9">
        <location>
            <begin position="8"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="10">
        <location>
            <begin position="289"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="8">
        <location>
            <begin position="619"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF84542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="702" mass="76466" checksum="87B15E1DEC9D474E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VKJ7</accession>
    <name>A0A1H5VKJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87740">
        <property type="protein sequence ID" value="SEF87740"/>
        <property type="gene ID" value="SAMN04489712_102354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF87740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="15107" checksum="AC59F2091D943F10" modified="2017-01-18" version="1">MRQPFDPAEPMVRPYVLTRGRVQPGRGSFDVITQVVAVSEPPSGDHRELSPEHLEILRLCQEPRSVAELAAQFGRVAEEEPEPAAPAPPSGGLPISVVRVLLGDLLEHGHIEIQEPEADNLRRIDLYKEIIVGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VMZ8</accession>
    <name>A0A1H5VMZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="11" type="ORF">SAMN04489712_102371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88211">
        <property type="protein sequence ID" value="SEF88211"/>
        <property type="gene ID" value="SAMN04489712_102371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="53"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF88211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="24221" checksum="97DEB2C8C81D61F4" modified="2017-01-18" version="1">MTGRPLSEIVDPGWASALEPVAGRIAAMGDFLRAEVAAGRRYLPAGEHILRAFKQPFADVRALIVGQDPYPTPGHPVGLSFSVAPDVRPQPGSLLNIFREYRADLGHPEPSSGDLTPWTEQGVLLLNRALTVAPGRPAAHRGKGWEEVTEQAIRALAARGGPLVAILWGRDARNLKPLLGGVPCIESAHPSPMSADRGFFGSRPFSRANQLLERQGGQPIDWKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VR88</accession>
    <name>A0A1H5VR88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89792">
        <property type="protein sequence ID" value="SEF89792"/>
        <property type="gene ID" value="SAMN04489712_102426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF89792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="100" mass="10841" checksum="1559A12611311C16" modified="2017-01-18" version="1">MADKAPDPEALEKEIERTREELARTIDALADRVNPRNVAQRGVARLKQEAGQVASTVGAMVAPAHGEDGEPGQVDRRVVAVGVGAVVFVTVFVLWRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VTJ6</accession>
    <name>A0A1H5VTJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89857">
        <property type="protein sequence ID" value="SEF89857"/>
        <property type="gene ID" value="SAMN04489712_102429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="194"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF89857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="31285" checksum="4514BEFCC85E298B" modified="2017-01-18" version="1">MRPVGQLRPGDHAWLAFGGGEERERIVGTFVTDGLATEEKVVYVTDTDPANLPGVRWPTGADPQDFVRSGQLRVLSREAACLTGGRFDPERMLDVLDEEVSQAFDQGFRAVRITTDLSWAVREAAEPVLGCEHRFGAAVSPSTMAMAICQLDRRRVPAGRLAALRDAHEVLVEVDPEFDDGVLRVVRTFDPHGLRVEGELDAARHMVFAERLSLAARGRRRVHLDCSRLRFLDLAGLNLLVAQAARLPHGGLLVLDRLPAEVAGVIETVGWHRLPGLARGRDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VYQ0</accession>
    <name>A0A1H5VYQ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysA</name>
        <name evidence="8" type="ORF">SAMN04489712_102516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92253">
        <property type="protein sequence ID" value="SEF92253"/>
        <property type="gene ID" value="SAMN04489712_102516"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="7">
        <location>
            <begin position="70"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="6">
        <location>
            <begin position="325"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF92253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="461" mass="49849" checksum="0D4E42179026E6EC" modified="2017-01-18" version="1">MSRVHPAGSRYADVLPEDHPLPPPADPNHLDPHVWPRSAHREDGALTIGGLDVRDLAARFGTPLFVYDEEDVRQRAREYAAAFHDGEVHYAGKAFLCTALARWLDEEGLGLDVCSGGELAVALAAGFPPEKITMHGSNKSMAELARGLEVGVGRVVVDSFEEIARLGYLAQERGVRPRVMIRVTTGVEAHTHEFIATAHDDQKFGFSRTSGAALEAVRRVLELGQLELVGLHSHIGSQIFDTDGFEVAAHRLAELLVAIRDEHSLELPELDLGGGYGIAYLPGDEPHDPKAIADSLRAIVARECRAYGLAMPRITVEPGRAIVGPGGVTLYEVGTVKDVEGLRTYVSVDGGMSDNLRTALYGAEYSCVLASRSSAAEPMLSRLVGKHCESGDIVVRDLWLPRDVTAGDIVAVAATGAYCRSMASNYNFVPRPAVVAVRDGEARVLVRRETEEDLLRLDAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W2E6</accession>
    <name>A0A1H5W2E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93620">
        <property type="protein sequence ID" value="SEF93620"/>
        <property type="gene ID" value="SAMN04489712_102563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF93620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="361" mass="41165" checksum="F50A7A8CFB8448BB" modified="2017-01-18" version="1">MTLSPLDDYPIHQVPEVMRHTGTSDRNFYDRYYFNCFPTSGEAMLIVGLGQYPNLGVTDAFALLRRGPLHRVVRASRELGADRMDTRIGPLRVEVVEGLRRLRVVLEDNEHGLAFDLTWDAAVPAQLEPPHFVRWQERVVFDSRRLAQTGQWTGSITVDGEVLEVTPDLWWGCRDRSWGIRPVGEPEPPGIQVKNAGTFYWLYAPMQFQTHSILCILQEDEKGRRVLEEAVRVWPDPEREPEYLGRPEYRPVYREGTREVETATISFAPPGGEPFDVQATPVLPVHLMVGTGYGLEPDWKHGMYQGPDLKVQGVSYDTRKEEDAARMWGMVDAVGRFEYDGNVGHGLFEYWALGPHPSFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W2N3</accession>
    <name>A0A1H5W2N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93762">
        <property type="protein sequence ID" value="SEF93762"/>
        <property type="gene ID" value="SAMN04489712_102567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF93762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="26293" checksum="D8E175D99959D056" modified="2017-01-18" version="1">MRTGLQGKTALITGASRGIGKASAMALAAEGANVVLSSRKQESLDEVAAEIRAAHPEVGVLAKAAHVGDAEQAAACVDAAVAEFGGIDVLVNNAGTNPYYGPMVDLDAARAAKTVEVNQFAIVQWTSLAWKRSMAERGGAIVNMASVGGMVTEGGIGYYNATKAAVIHLTRQFAVELAPAVRVNAIAPGLVKTHLARALWEPNQERISKALPLGRLGEPEDIANAVVFLAGDAASWMTGQTLVVDGGSIVRPSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W923</accession>
    <name>A0A1H5W923_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PTS system N-acetylglucosamine-specific IIC component, Glc family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_102632</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95890">
        <property type="protein sequence ID" value="SEF95890"/>
        <property type="gene ID" value="SAMN04489712_102632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="11">
        <location>
            <begin position="17"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="427"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF95890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="472" mass="49596" checksum="109AE4DEA114785C" modified="2017-01-18" version="1">MSSSTAVGGTAAPQRGSSVLAVLQRIGRSLMLPIAVLPAAGLLLRLGQPDVLGENDDAWISFAGSDRVAEVFAAAGGALFNWLPLLFAVGVAVGFARKSDGSTALAAVVGYLVFHYVSMNMFFHSDELRPRVVKALFDPDNPGKPNEVLDLAAGNPTQVLGGIVIGITAALLYQRYYRIKLPAWLAFFGGRRFVPIITAFTATLLGLLFGLIWPLLGGWLTNFGEWMERNSTLGAGVYGVVNRLLLPLGLHHIPNNVVWFQIPECTVGGKTYTGDLNCYLNGADGAGWSMAGYFPVLMFALPAAALAIWHAAPRHRRAAVGGIMFSAALTAFVTGITEPIEFAFIFVAPVLFGVHAVLTGVSMALADALNMKLGFSFSAGAIDMVLNASKDNTKNLLGLIILGLIYAVVYYFLFSVLIRAMNIPTPGREPEGTESVAADPSAAPEVAAASASTEAGASPSSGAKAKSESSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WEE4</accession>
    <name>A0A1H5WEE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-tubulin suppressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97626">
        <property type="protein sequence ID" value="SEF97626"/>
        <property type="gene ID" value="SAMN04489712_102685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009288192" evidence="1">
        <location>
            <begin position="19"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF97626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="401" mass="41511" checksum="A3AFDB7339DBC0E7" modified="2017-01-18" version="1">MAAVVIATVIAPSGTAAADDGTGTPINRTVGWGSNAYGQAGSGIVQAQHRTPVEVAGWPQSRYSQVATGETHSLGIGPNRVLQSWGSNSCGQLGTAGGSRNVPEPVRGAPSNMYGVAAGRDFSLALTGTGRVYAWGCNDKGQLGLGTTSGPIRSPALVPGLEGIIQITAGYDHALALTWDGLVYAWGLNDDGEAGDGTASPRPAPVPVYGLNNVRAVAAGIHHNLAVRNDDKLFAWGRNASGQLGTGSSYQDQLTPVQVPIPARVQNVAAGGHHSLALTTSYQIYAFGDNSYGQLGFGDLVNRTTPTLIPSLSAIHNVSAGVDFSLAQTPPDPAFPRYSIYAWGRNHIGQLGTGSTASVNAQPELVHRTRDEPPLRVAGVFAGSSSRHALAIQVTPWWTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X0W5</accession>
    <name>A0A1H5X0W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pilus assembly protein CpaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05358">
        <property type="protein sequence ID" value="SEG05358"/>
        <property type="gene ID" value="SAMN04489712_10341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RcpC" evidence="1">
        <location>
            <begin position="116"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG05358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="26289" checksum="85158EFF2B7162CC" modified="2017-01-18" version="1">MNRRLITIVVAVALAGLGSLMVYGYVRAADERALRGQRPVDVVVAAKAIPAGTSVTRLVPDGYATIRKFPAASVPDGILSRIEDAGPDMVVGSGVKEGELIRRALLVRRGATQAFTVPDGKIALTVELTDPQRVAGHVVAGSKVAVFVTVKILNSDGKPRGELTETRLLMSGIEVLSTGPAAEAKDKKSSAETRATSLVTMAVTQRQAEKLVWSSSGMRPGEGTALYLGLEGGSSELSETGSGVSSFKVFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X6I6</accession>
    <name>A0A1H5X6I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07351">
        <property type="protein sequence ID" value="SEG07351"/>
        <property type="gene ID" value="SAMN04489712_103110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289116" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG07351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="51" mass="5187" checksum="42CCDC2B9CC682A1" modified="2017-01-18" version="1">MNKKWVKLSALAFAAWYVITRPVGAADAVSSAAGGLGNAAESVSTFFGAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X8I1</accession>
    <name>A0A1H5X8I1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_103140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08068">
        <property type="protein sequence ID" value="SEG08068"/>
        <property type="gene ID" value="SAMN04489712_103140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="90"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="161"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="336"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="413"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG08068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="550" mass="61368" checksum="A9F2734E0801573F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XE56</accession>
    <name>A0A1H5XE56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphinothricin acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09486">
        <property type="protein sequence ID" value="SEG09486"/>
        <property type="gene ID" value="SAMN04489712_103194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG09486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="17187" checksum="470C9C855957594E" modified="2017-01-18" version="1">MLSEHADEVLAIFRAGIEGGNATFETAVPSWAGFSAGKLPGHRFVARDAGRVLGWVALSPTSTRAVYRGVVELSVYVHPGAQGRGVGRALLGAVIDSSERAGLWTLRAGIFPENTASLRLHEAFGFRRVGVHERVGRHDFGGQSRWRDVVLLERRSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XJG7</accession>
    <name>A0A1H5XJG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11889">
        <property type="protein sequence ID" value="SEG11889"/>
        <property type="gene ID" value="SAMN04489712_103284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG11889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="428" mass="48028" checksum="BE8A039553186D79" modified="2017-01-18" version="1">MAQPLREAEIDLSDLEFWGRPRRQREAAFAALRARERPVFFRELKVPFIRSGPGYYALVRHADVVEASRRPDVFSSEPCSTSIADQPAYMARYFGSMINMDDPRHAKIRRIVSRAFTPRVLAKLEADLQTAATRIVDDLVARGPGDFVEQVAARLPVAVICDMMGIPAERRAMVLERTNIILGLGDPEYSGLEPTASPDGFTRPAALYGLLRVMTAGYELNHLAMRLARRRRREPGDDLVSALVRAEVDGERLTDQEIGSFFILLVVAGNETTRNAMAHGLKLLTDHPDQRALLLADFEGRIGGAVEEIVRMSTPVIQFRRTVTRDHEMNGHQYRTGDKVLLFYNSANRDEAVFENPDVFDITRSPNPHVGFGGPGPHYCLGANLARREITVMYRELFTRLPGIRAAGRPDRLYSNFINGIKHLPCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XK95</accession>
    <name>A0A1H5XK95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11830">
        <property type="protein sequence ID" value="SEG11830"/>
        <property type="gene ID" value="SAMN04489712_103282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022183">
        <property type="entry name" value="DUF3710"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12502">
        <property type="entry name" value="DUF3710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG11830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="30058" checksum="9A21B4257CF7BD5F" modified="2017-01-18" version="1">MPIRRRRQDEESDSTLEQAGEQADAVETDDAPAGEAGGAAGPWDSGDSYPELERLDFGSIQVPVGPGLGFQVNFEATEVDAEGNPLNGRPVSVLVQHAESVLQVQAFAAPKRSGIWDDIRRETATEITEQAGGQAEDREGPFGTELLAMLPAQLTEEVLNEMPPEVREQIPQEVIEQGYAWQPIRFIGVDGPRWFLQGVVQGAAIEDEEQWQVLEDVFRNIVVLRGEQPMPPRELLPLTLPKEFSEAAGEQQEEGGSDTFDPFERGPEITEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XKC3</accession>
    <name>A0A1H5XKC3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="6" type="ORF">SAMN04489712_103283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11860">
        <property type="protein sequence ID" value="SEG11860"/>
        <property type="gene ID" value="SAMN04489712_103283"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG11860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="17176" checksum="2DE824F8E6EEC179" modified="2017-01-18" version="1">MTNKSAPHAHGDVPVLIRRLDDGLPLPSYAHPGDAGADLFAAVDVELGPGERAVVPTGIAIALPDGYAAFVHPRSGLGARFGVTIVNAPGTVDAGYRGEIKVTLLNTDLRHPVRLRRGDRIAQLVVQRVERAAFHEVSALPGSVRGDNGFGSTGGLSAAAPEAGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XSF2</accession>
    <name>A0A1H5XSF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14465">
        <property type="protein sequence ID" value="SEG14465"/>
        <property type="gene ID" value="SAMN04489712_103381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG14465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="13139" checksum="4C573618ACFD9FE2" modified="2017-01-18" version="1">MGGPDTAAGFIARLRDFHLECGEPSYQTLVDISEQLPDLYPDLLQWRDLPTLSRSTISDVLNRKRVNLPSAAWVVVFVLSCQRRALETCVLMDDPGLSVLPKWVELWQQARVAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XVN4</accession>
    <name>A0A1H5XVN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-methionine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15450">
        <property type="protein sequence ID" value="SEG15450"/>
        <property type="gene ID" value="SAMN04489712_103418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="14"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG15450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="22750" checksum="655F992A4CA087CA" modified="2017-01-18" version="1">MTWDELAPLLRDATLETLQMTLWSAVLTAVGGLLLGVLLVLTERGGLLPVPPLNKVLGAVVNVGRSLPFIILMVAILPMTRAIVGTTIGTTAAIVPLTVAAVPFYARLVETSLREVDPGVIAAARAMGASRRQIVGKVLLREARPGLVAGLTITVIALVGYSAMAGAIGGGGLGDLAVRYGYQRFETGVMVATVVLLVGLVQLVQTLGDLVARRLTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YJ60</accession>
    <name>A0A1H5YJ60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine phosphatase RsbU, regulator of sigma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23732">
        <property type="protein sequence ID" value="SEG23732"/>
        <property type="gene ID" value="SAMN04489712_10426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="167"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG23732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="41711" checksum="5F584CFB8B2617D4" modified="2017-01-18" version="1">MTEDQFSAIEEAVWEARPHAVPQAAARLVKTHFDASRVETLLADYRMAYLIPATGDAEPVPLDAGPAGRAYASQQVITEPVTGSPAHRLHLPLTVHGDRLGILTVELPGPPGAEHRLRLAAVASALARAIKIADGHTDAYRQIRRRARMTLAAEIQWDLLPARTCSGDEFSLAGQLEPAYAVWGDNFDWALAPDHLTVTVTNGMGRGTQAALLTHLTVSALRNARRSGSGLTEQAALANEIVYAHHHGELTSATLLLGFDLRTGRVTAVDAGSPLVYRLRGNTVDPIALEPQLPLGMFNDTGYTEEEFSLQPGDRLVVVSDGVHGALSPGGEAYGSLALARALRQTRLQGPPEAVRTLMRGLLDYHEDTDLADDAVIVCIDWTGKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YTL0</accession>
    <name>A0A1H5YTL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27052">
        <property type="protein sequence ID" value="SEG27052"/>
        <property type="gene ID" value="SAMN04489712_104161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="26372" checksum="3585435A6A3C2880" modified="2017-01-18" version="1">MTHGLARVRTVSVRSLRVVAAHPMIRRLLVLGGLVVTGWLLGGLAGTAHADVSSPCSAFSGEVRKPAAVKRVFPAAPPSGLPDRPRTAEGGPALPDPRVLGRIGDLLSERLPEVVDPPGGRERTEPGPSGRTVPADPGDESPRREHDRDTGADDTARIGFSGPGTTLGTGTLTDGGPRADEDRTSRGLTDEDHPPMGGDWLPPAAESASAGVGGPLGGYLGQAVQAERPAPVPFSRPGVDAPVVRTAVDEPFFAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z2M9</accession>
    <name>A0A1H5Z2M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30512">
        <property type="protein sequence ID" value="SEG30512"/>
        <property type="gene ID" value="SAMN04489712_104311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG30512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="105" mass="11405" checksum="F6DCF3062E3270C4" modified="2017-01-18" version="1">MSWATSDEVSVLWAEHLGLAFPDDLKGVEIHGEPVALLDAYTAGCVTGYVGGRLSDHQRLVLDDCARALRDLLPRLRHGEGHGYVARLVRMADLILSDSPRVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z5J0</accession>
    <name>A0A1H5Z5J0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="9" type="ORF">SAMN04489712_104378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31789">
        <property type="protein sequence ID" value="SEG31789"/>
        <property type="gene ID" value="SAMN04489712_104378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="8">
        <location>
            <begin position="57"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG31789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="237" mass="26485" checksum="BDAA4C99A3CF3DC6" modified="2017-01-18" version="1">MSESPQPHDEAVEEPRSAQEAAVEPAETPQDDEVEAVEETPAEDPYADFKMQLRMQPGDWYVVHSYAGYENRVKTNIETRTQSLNMEDYIFQVEVPQHEVTEIKQGKRQKVNEKVLPGYILVRMDLTDESWAAVRNTPGVTGFVGLLNKPSPLSLDEVANLLAPEPEEKAKVKEQAKVTATVDFEVGESVTVMDGPFATLPATVNEINVEQQKLKVLVSIFGRETPVELSFNQVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z735</accession>
    <name>A0A1H5Z735_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32082">
        <property type="protein sequence ID" value="SEG32082"/>
        <property type="gene ID" value="SAMN04489712_104392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="58"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="147"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG32082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="450" mass="47366" checksum="C55BC575160F9371" modified="2017-01-18" version="1">MSRVTRTRSAGSAGLRRRPARLGLAAGATAAALALSGCGFRGVDSIPLPGGPDLGDRPVTVRAEFANVLDLVPQSVVKLNDVSVGKVTEVELARGTAPGQSWQAVVTFKLRRDVNLPDNARASITQTSLLGEKFVALSPPAGEAPSANRLGDGDLIPITRTSRGAEIEEVLSAMSLLLNGGGLEQVSTITHELNAAMNGRTGTIKSVLHRVDTFVGTLDTNRAAIVRAIDSIDRLSKKLADERATIADTIDRTGPAIDILNRNRADLTKMLVSLDKLSRTTTRVINASQADLVANLRSLDTTLRNLNKAGANLPKALETMLTFPFPATFSNVLRGDYGNLHMTIDLDMKNLTHNLLGGTDLEYLAQQGEQMRLLLKPPSLSVPQPPLGVLPDLPAQPAPPAGDTPGTGGARTPAPAPTASPTGSTAPRPRALAPMEGSSDLYKLMTGGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A074</accession>
    <name>A0A1H6A074_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41634">
        <property type="protein sequence ID" value="SEG41634"/>
        <property type="gene ID" value="SAMN04489712_10590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG41634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="613" mass="62939" checksum="37EF2A008EEFCD71" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A3R9</accession>
    <name>A0A1H6A3R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase / fumarate reductase cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43081">
        <property type="protein sequence ID" value="SEG43081"/>
        <property type="gene ID" value="SAMN04489712_105177"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
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        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG43081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="25707" checksum="3542C8126E882692" modified="2017-01-18" version="1">MLQTSPRAIPALYRSSVGKKAIMAVTGVLLVLFLIAHMVGNLKVFLGPAEIDEYAAWLRTIGAPLLHHEWFLWIQRVVLLAALVLHMTMAYQLARRARRARPVRYRHRAKVQGSYAARTMRWGGVIIALFVIYHILDLTTGTVNPGYQHGEVYRNLVADFAPERWYVTLFYTLAVVAVGFHLRHGLVSATQSLGAASPQRARTLNLAATAFAVVMVAGYLSVPFAVTVGLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A5K7</accession>
    <name>A0A1H6A5K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43307">
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        <property type="gene ID" value="SAMN04489712_105189"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG43307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="75" mass="7495" checksum="17E0910736C1BEB0" modified="2017-01-18" version="1">MARTVSIVAALVGSGPGEAVADMAREAIGKTVCVKCAGSARGDARPVALVPPPAGVSSRARAGRLRGEPTRPLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AA75</accession>
    <name>A0A1H6AA75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45643">
        <property type="protein sequence ID" value="SEG45643"/>
        <property type="gene ID" value="SAMN04489712_105315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG45643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="302" mass="31113" checksum="13628E2C3CAE4F25" modified="2017-01-18" version="1">MYGDHPRSPGRRDEHSDARQPSPPEQARHPFGPAVPPEDVRVAGNPFGAPAGPGQGDGSMPGRPHGADTIGDDDGSARAGAPGSGAAGKGLATRLPVKLAAVAGAAVVLVGVGAVAAFAMTGGEENTTVKPRALADAPKPPDPKVLEEQRRQQNLDRASRAAVKDAGKPMELEAKGHTPTPTPTSAAGGDGDAPPAGNPVPAGEAQRIAKAMLPSFGFDPSTQFGCLVNLWQKESGWRHTAQNPTSGAYGIPQALPGSKMASAGADWRTNPRTQIKWGLGYIKGRYGNPCGAWSHSQRVGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AAW7</accession>
    <name>A0A1H6AAW7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_105312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45591">
        <property type="protein sequence ID" value="SEG45591"/>
        <property type="gene ID" value="SAMN04489712_105312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG45591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="418" mass="44932" checksum="C4854DAECDC91F45" modified="2017-01-18" version="1">MSQSERLVLATRYRLVSEIGQGANGTVWRGHDDLLDRAVAVKELRLPADLGEDDRVVFYRRTLREARAPAQLRTPSIVEVYDVVIEQGRPWIVMELIEAPNLEQLIERDGPLPPERVAHIGRQLLDALAVAHRSGIIHRDLKPSNVLLDGDRVVLTDFGLAFSPGAAHLTKSGHFVGSPAYVAPEVAAGERATPQSDLWSLGATLYAALEGRPPFDRGNVMATLSALANEEPAPPQNAGPLAPVLTGLLQKNPLRRLSHARAVDRLERAMSAPRAARRQATPRYRLAVVVGLIAATVASCGVGTGALIVGMMKESPGRAAAGESPASATGRPAAMPPAAAANPLVVRAIGDTCKIFVTEAGSLNFEFRGTMARGEERVFDKPRLSVVIYDTAACEVWIKGVKQPQGQPGTRRDLLVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AK69</accession>
    <name>A0A1H6AK69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49129">
        <property type="protein sequence ID" value="SEG49129"/>
        <property type="gene ID" value="SAMN04489712_105516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG49129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16498" checksum="D282EA43DCA1336E" modified="2017-01-18" version="1">MTTTPRQPAAPAPDPDPGPIARRLDHLFRTVHPRDRGPYTHKEAAEAINAAAGEQVISPAYLWQLRKGTRTEPGHKRLVAIAKFFGVDVTYFTDDQTAAHAASIVAPPRSPPARPRARRTPGGPWSGIRSATARYPAIRSAREQQPNGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ANT5</accession>
    <name>A0A1H6ANT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49426">
        <property type="protein sequence ID" value="SEG49426"/>
        <property type="gene ID" value="SAMN04489712_105531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG49426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="27522" checksum="E52E695721FCC75A" modified="2017-01-18" version="1">MDLNIKDRVAIVTGGSKGIGLAAATELGRAGARLVLSARGETDLEAAVGRLRDDGVEAVGHVADAARAEDIDGIYEAAISAYGQVDIAVCTAGGGHGPLRDFSWDQWIELYELNVLSAVALAMRCVPAMRERKWGRIVFVGSTAGREADPRFAAYGAAKAALLHAAKSLALGYAKHGVLTNCVLPGLTRTEGVLAGYEEQAERLGVTPEDVERRMLELQPIAAGRTGEPAEVADAIAFLCSERASWIAGSALLVDGGTIRVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWA5</accession>
    <name>A0A1H6AWA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-methylcytosine-specific restriction enzyme subunit McrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52500">
        <property type="protein sequence ID" value="SEG52500"/>
        <property type="gene ID" value="SAMN04489712_10635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019292">
        <property type="entry name" value="McrC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38733">
        <property type="entry name" value="PTHR38733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10117">
        <property type="entry name" value="McrBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="44243" checksum="7E3596FBC62AEF37" modified="2017-01-18" version="1">MMPITLVEHGPAVSHPLDDALGRALAASRLVSAAPEAGRPGHWQIRAKGKVGVATVTAPAGGAVTVWIRPKVPIARLLFLLGYALNPRGWRDEDVALDTDDELLPVMARLFERQAERVLRQGLLRGYRIAEETSTLVRGRIREADQLRRHHGRLVPVEIVHDEYTSDITENRLLLTATERLLRLSHGVPADVRGGLLRLRTRLAGIAPIKRGHEPLVWRLNRLNARYQHALRLAEIVLDGCSVEQRPGGVTVSGFLFDMYKVFEDFVTIALREALPGDGHCELQSNQHLDERREIRMIPDLVHHAVDGTPLAVADAKYKVERPKGYPDADLYQMLAYCTALNLRDGHLIYAKGNAPHAAHRVRHARITIHQHTLELNQPAADLLTEIQALAQRLVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXS5</accession>
    <name>A0A1H6AXS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52857">
        <property type="protein sequence ID" value="SEG52857"/>
        <property type="gene ID" value="SAMN04489712_10658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="10445" checksum="871F73A27FA56F88" modified="2017-01-18" version="1">MTSGFVRLGLHRYVPESASESPPPPLIEESPGQESEVVLGEELMRLLVLRELRRRLHLSELVLLGVRQQRVDDGGVKLGVILGLHIGGNGADVGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B7F3</accession>
    <name>A0A1H6B7F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted kinase, aminoglycoside phosphotransferase (APT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56781">
        <property type="protein sequence ID" value="SEG56781"/>
        <property type="gene ID" value="SAMN04489712_106336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="34"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="359" mass="39048" checksum="9648F809FD6A9265" modified="2017-01-18" version="1">MSGELATEVPGVDVPRLAAWLDRTLPGGGRITGVRLIAGGRSNLTYGITLDGGRRIVLRRPPLGHVLPTAHDMAREYRVLSALAGGTGVPVPQPLAFCSDEDVIGARFYLMDHVDGRVLRTAEDAADVTPEQARELSERLAEVLAAIHTVDVEAAGLADFGRPAGYMARQLKRWGQQWERSQEAIAATGASRDLPAYERLVARLGERLPADGRFSLVHGDYRLDNALTLLEPRPQIAAVVDWEMSTLGDPLSDLGLTLVYWAEADDADRLPVGATVTAAPGFLTRRRFAERYAEITGFDLSDIDFYVAFACFKLAVILEGIHARYLQNATVGEGFDKIGDGVPLLLDRAHRILDTGSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BFN3</accession>
    <name>A0A1H6BFN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type branched-chain amino acid transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59135">
        <property type="protein sequence ID" value="SEG59135"/>
        <property type="gene ID" value="SAMN04489712_10749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293661" evidence="1">
        <location>
            <begin position="22"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="51"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG59135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="423" mass="44002" checksum="432875AAB71F829E" modified="2017-01-18" version="1">MKSTLRMTAVTAVALALAAGAAGCASDKATGGSGGAGADGVKQGPGVTDKTIKLGVATDLTGVYAPLGKSLTQSQQLYFEQTNAAGGVCGRKIETVVRDHGYDPQKAVSIYSELSTSVLAIPQFLGSPMVTAVKQRIESDKMFTIPSAWSTTLLGSEPIQVTGTTYDVDMINGIEWLLSKKLIKKGDKLGHVYFEGDYGGSALRGAKFAADKHGLTIVEQKIKATDNDMGPQVAALSKAKVAAILMSAGPRQSASLAGIARSQGMKQPILGSNSAFSPQLLATPAKPALVEGFFFTSAGAPISADLPEVKKLADAYAKKYPGQPMDSAVVSGYGNGAIVVSALKKACEAKDLTREGLIKAHRSDANADTGLGTPMNFTYFDKPATRKTYVLQPKDKIPGGAVIVQEATESELATTYQPPVGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BGA7</accession>
    <name>A0A1H6BGA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein TerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59700">
        <property type="protein sequence ID" value="SEG59700"/>
        <property type="gene ID" value="SAMN04489712_10785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="20475" checksum="D23B2D29180CE0B9" modified="2017-01-18" version="1">MGVSLAKGGNVSLSKAAPNLTAVAVGLGWDVRATTGADFDLDASALLLNSAGKVISDQHFVFFNNLRSPDGSVEHTGDNLTGEGEGDDEVINVTLTQVPAECERIVFPVSIYDADNRGQSFGQVRNAFIRIVNRADNSELARFDLTEDASTETAMVFGELYRYQSEWKFRAVGQGYASGLAGIAMDFGVNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BGK4</accession>
    <name>A0A1H6BGK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein YbjQ, UPF0145 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59752">
        <property type="protein sequence ID" value="SEG59752"/>
        <property type="gene ID" value="SAMN04489712_10788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG59752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="169" mass="17614" checksum="2A2EA4D731F71542" modified="2017-01-18" version="1">MNVHRSSTVESMLIVTTDGLPGFEIRRVLGPVLGVAVHNDQGMVPGPSPSSGTFRRSTGEQPGLGLAPTRREAVQRLAEEAQRMGANAVVGMCFDNALVGGGRGGHEVCAYGTAVVAEPAHGQAQGQHQYAKTGPQGQPAPPPYVEPQPGRPPMVGRNLTIGLHGDNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BHB1</accession>
    <name>A0A1H6BHB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv1855c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59982">
        <property type="protein sequence ID" value="SEG59982"/>
        <property type="gene ID" value="SAMN04489712_107102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="31117" checksum="A43FCBABD764263F" modified="2017-01-18" version="1">MRIGIQVPAFDFSGGTEQIGPAFARVARDADQAGLDSLWVMDHFFQIGMVGPAEQPMPEGYGALAYAAALTEQITLGTMVTGVIYRHPGVLVKTVTTLDVLSGGRAWLGIGAGWYEEEARGLGLPFPPTAERFERLEETLQIALRMWEGDESPYQGRHFTLERPLNSPQSLQRPHPPILIGGGGEKKTLRLVAKYADACNLFASPELPHKLKVLREHCEREKRPYEEIEKTVLAVLEAGASVDQVVDQVGTLAEQGADHVIFSARQADKVTGVLAHVREQVGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BMR8</accession>
    <name>A0A1H6BMR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_107265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62009">
        <property type="protein sequence ID" value="SEG62009"/>
        <property type="gene ID" value="SAMN04489712_107265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG62009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="27665" checksum="E47099B1A887B173" modified="2017-01-18" version="1">MSAVLRIESVSRAFGGVYAVRDVSLTVAEGETRAVIGPNGAGKSTLFNLISGHLVPDAGTVSYGPRGQWRRIDGLPPHARARLGIAIVFQGARLFGGMTALENVMVGAHARTRHGFLAGALRLPGQRREEAEIRADALAALERVGLREWAHRAADVLPLGQQRSLQVARALCARPRLLLLDEPASGLRAAEREALAQLIEGLREEGLTTMLIEHDVAFVARLADRVSVLDLGAHIAEGTPEEIRADEAVLTAYLGEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPD2</accession>
    <name>A0A1H6BPD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RIP metalloprotease RseP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_107300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62492">
        <property type="protein sequence ID" value="SEG62492"/>
        <property type="gene ID" value="SAMN04489712_107300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="111"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG62492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="41525" checksum="A555D7BD537384C1" modified="2017-01-18" version="1">MAYLLGVVAFVAALVLSVVLHEAGHLVTAKRFGMKATQFFVGFGPTLWSRRRGETEYGVKAILLGGFVRIVGYTTLEPIDEADRPRAFHRQPARRRAVVIAAGVAANFAFAFVLLTVLATAVGVRDPGTATNTVQRVGACVPASLGAGCREGDPPSPARQAGLRAGDRIVSFAGTPIADWEQLRAAIRAARPGRTVPVVAERDGTRQTLQVRLAEVDREPFLGVTARVVGAGYDRLDPGAAVVFAARGIGLAVAQMGRALAALPAALPDLFSPERGQSTGGQVGSVVGAGQTSGEIFASGGSWRDKVAAYLALVASINVFLGALNVLPLLPLDGGHLAVVGYERLRARIARARGRPDPGPVDITRLLPVTYLVLLLLLGLGILLIAADVLNPLQVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C790</accession>
    <name>A0A1H6C790_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68839">
        <property type="protein sequence ID" value="SEG68839"/>
        <property type="gene ID" value="SAMN04489712_10924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="2">
        <location>
            <begin position="117"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG68839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="21274" checksum="2A788094BD4A4438" modified="2017-01-18" version="1">MAEPAAEPAAESGAGPTVGAVAEGADGRTRLDDARIVGRLERLEEVLSRLEQVPGPTTETALDAVTLLVEVYGEALARVMDRLALQPGLAGELAGDELVGHLLVLHGLHPAPVAERVARAIDGVRPYLRSHGGDVQLVGIEDGVARVRLSARGCGSSTALLREAVDAAVAAAAPELSGVEPVRAGGPAAFIPAEALLSRPVPHAPEGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7M9</accession>
    <name>A0A1H6C7M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv2161c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68974">
        <property type="protein sequence ID" value="SEG68974"/>
        <property type="gene ID" value="SAMN04489712_10937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="31377" checksum="3CCF7FD563085DE6" modified="2017-01-18" version="1">MRFTYAEAMTDPSYHLPLAQAAEAAGYSSIAVADSLVYPRESDAGYPYTADGDREFLEDKSFVETFTLIAAMGAVTSTIRFTPFVLKLAVRPPVLVAKQAGSLAFLTGNRLGLGVGLSPWPEDFAVMGVPWARRGRRMDEAIAVIRGLTGGGYFEYHGEFYDLPPVKMSPAPTEPIPILVGGHSEAALRRAARLGDGWMHGGGDPGELDTLLARLAALRAEEGTADRPFEIHAISPEAYTVDGVKRLADKGVTDLIVGFRNPYVKGPDTQPLAKKIEHLERFAESVIAKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C996</accession>
    <name>A0A1H6C996_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69541">
        <property type="protein sequence ID" value="SEG69541"/>
        <property type="gene ID" value="SAMN04489712_10994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="33262" checksum="9110DB5FC5AE8F0B" modified="2017-01-18" version="1">MDHARPFRPDGWWERDGRDDAEPPVDLDLSGPSPARVYDHLLGGKDNYETDRALAERMLRVQPMLGLAARQNRAFVGRAVRRLAQAGFSQFLDIGCGLPARDNVHQIADRTMPGARVVYVDNDPVVLAHGRALLVENANVAVLRADLRDPEHVLDTVRAGRLLDFQRPVAVLLTAVLHFLADADGPQEAVARIRRALPAGSALAVSHLASDVATAATAEAARLFAAECGRPLVPRGREEVAGFFGDLAPVDPGLVFTGEWWPDIASQPPEHSLMYAGVACSRPLSSPPAETTARPESRPSGCNPVHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CHV3</accession>
    <name>A0A1H6CHV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72478">
        <property type="protein sequence ID" value="SEG72478"/>
        <property type="gene ID" value="SAMN04489712_1104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG72478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="427" mass="44928" checksum="6DF1183AED60033C" modified="2017-01-18" version="1">MGAVWRARDMQLDREVAVKELRLPEHLGAAQREKWIARLDREARAAARLKHPGIITVHDLVKGDDGRPWIVMESVHGGSLDDLLKARGPLTPQQVAAIGLRMLDALHAAHRAGIIHRDIKPANVLLEGDRVILTDFGIAALGDDAALTRSGEVMGTPAFMSPEQVRGLPTSAATDLWSLGATLYTAVEGRPPFPGTSTGAVFVAIATEDPAPAAHAGPLEPVINGLLRKDPAQRLTAEQVHPMLLQLGASPPAHAAVHGHVPAQAPAHWPPPPVPGTPTAYRGKPLWAVLAVAAVAVVAAALVFAFVIASGGDSAYENNLSIAEKLGAPSGYTRTSEKNVGGGRAQVTLARTCTTGCSGPATADHPAFKAVREWLVTRPGIAAVSPAMPALDRKSCIINVQPVRTPGVIKVQVVLRDDKTLLQIEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIX0</accession>
    <name>A0A1H6CIX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_11051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72924">
        <property type="protein sequence ID" value="SEG72924"/>
        <property type="gene ID" value="SAMN04489712_11051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="286"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="472"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG72924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="611" mass="67098" checksum="4C09689D218782B3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJ12</accession>
    <name>A0A1H6CJ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72705">
        <property type="protein sequence ID" value="SEG72705"/>
        <property type="gene ID" value="SAMN04489712_11028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG72705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="402" mass="41144" checksum="538EC6EA1BE8FFCA" modified="2017-01-18" version="1">MKLSHGRLLVGCGLATVGTALIPTALTLAVLHGTGSAADLGIVLSAELLPLVLLLPVAGVVADRLRPELIILVADLVRAAAQIAMGVELLYGLTRIPDLAVLSAITGAAVAFGMPAVRGLVTATVPGPQRLRTNARLGVVQGVSQVAAPSVAGGLSIALGAGWSSVLTGGLFALGAITIGGMRTPAARPREQAGPGAFFAEMREGWAETRRHRWFFYSVIGHGVWHLAAGFLLTLGPVIAVRHLGGESSWVAIVQVGMIGLVAGIYLAGRLPIRRPLVVVAVCTASYALPLTAFGLHASMPMVTAAYCAAMFGLGLLSTLWETAMQDRIPAEAMGRVGAFDALISFAVRPLGLAVAAPVAALTGTAVPLLVGAVLVAVVNLAVIALPDIRKEPARTAAEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRX5</accession>
    <name>A0A1H6CRX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75403">
        <property type="protein sequence ID" value="SEG75403"/>
        <property type="gene ID" value="SAMN04489712_11133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="27518" checksum="2A8316B57C734A59" modified="2017-01-18" version="1">MDVRGARVLLTGASGGIGQALAAAFAARGAHVILTGRRADVLEPLAERLGGRAVVADLTDRSVIGDLLDRAGEIDILVANAALPASGRLPDFTVGEIDRALDVNLRAPIVMARLAGERMAERGRGHLVFISSLSGKSASGGASLYNATKFGMRGFALALREELRPRGVGVSTVFPGFIREAGMFADANVTLPRGVGTRSPQDVARATIRAVERNRAEVDVAPLGLRLGVLVAQVSPGLNAFVQRHFGGAEVTRALAKGQRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUW4</accession>
    <name>A0A1H6CUW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76483">
        <property type="protein sequence ID" value="SEG76483"/>
        <property type="gene ID" value="SAMN04489712_111169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="16020" checksum="8818266DF9C82C51" modified="2017-01-18" version="1">MTTEQHTRRTVEELLDRIGAGEPERIAEMFAEPVEWGLSWPAEGHPALPWIRPRSNRADVADHFRQLDDFHVREKNGTTVDRILVDGADAVVLGRIVQTVKATGREYASPVALHLTVENGLISRYHIYEDSLTIAEALTAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUY5</accession>
    <name>A0A1H6CUY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein, gntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76782">
        <property type="protein sequence ID" value="SEG76782"/>
        <property type="gene ID" value="SAMN04489712_111206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="81" mass="8821" checksum="D8B0E7554851348B" modified="2017-01-18" version="1">MEEIKVGPIPKYQQLAAILRRRIAAMEPGDPIPSETELEMETGLARGTIKKAVALLRNEGLIVTTRGLGSFVAEHPPADEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZL3</accession>
    <name>A0A1H6CZL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG77995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77995">
        <property type="protein sequence ID" value="SEG77995"/>
        <property type="gene ID" value="SAMN04489712_11212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="17"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="38670" checksum="BE69AE19F2DF4ADE" modified="2017-01-18" version="1">MPSLQLTDTVGDQVVIAVDPHKASWTAVAVDRRLQPLATMRVPAGKAGYRQLRRFARAWPQARWAIEGARGLGAPLTSWLAADGIAVLDVPAELARRVRLLSAGHGRKSDEADALSVGIAAQTATRLHAARTDEAVAALRALIEHREDLVRTRTQTVNRLHALLTKLLDAGLPRKLTADIAAKALRRVRPEDTLGHTLRALAADLVAEIRRLDRRITAIAEQISAAVAASGTTLTELHGIGDLLAAKIGARTAGIDRFRSAAAFASYCGVAPLEASSGDVRRHRLSRAGDRQLNCALHIMAITQIRRPTAGQAYYQRKRAKGKSHKEALRSPKRRLRDVVYRTMIRDTDTSLLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1G8</accession>
    <name>A0A1H6D1G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_112102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78625">
        <property type="protein sequence ID" value="SEG78625"/>
        <property type="gene ID" value="SAMN04489712_112102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG78625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="21176" checksum="31BAF1E49F138F88" modified="2017-01-18" version="1">MVDDQDLVREGITALLGLQPGIEVVGSAGDGAEAVEAIVAARPDVVLMDVRMPGLDGVAATAELRRRAPECTIVMLTTFDDDEYVAGALRAGAVGYLLKNLPAADLARAVRLAHAGVAQLDSAIVTRLAAGLHGPAVLTPLTPRETEVLRLISAGATNREIASRLHVSEGTVKNHISRILQRLGLRDRTQAALYAKEHGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D478</accession>
    <name>A0A1H6D478_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-binding universal stress protein, UspA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80132">
        <property type="protein sequence ID" value="SEG80132"/>
        <property type="gene ID" value="SAMN04489712_11321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="137"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="27183" checksum="591E8999324C86E8" modified="2017-01-18" version="1">MIGEHVLTGYSDDSGGREALECARAIVALTGGRLTVATVHPPGRAGAAAEAGTTLRQAAGLLDEEPADYLAQESRGVGRGLSVLAGKVGADLIVIGSAAGGARGQITIGSAADHLLHASSEAVLITPAGYTPPERLQRITVAYVRRPQCDEAVERTAVAAARLGVPLRLLTLALDEADSGRLRDDLALAVPVAAGNSGLEPSAVQTALAEGGDVAAALARTDWEDGELLVCASSEDSAVHRVFLGEVALKVLRAAPCPVAVLPRGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4L6</accession>
    <name>A0A1H6D4L6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autoinducer 2-binding protein LsrB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_11347</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80240">
        <property type="protein sequence ID" value="SEG80240"/>
        <property type="gene ID" value="SAMN04489712_11347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015762">
        <property type="term" value="P:rhamnose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030159">
        <property type="entry name" value="LsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013459">
        <property type="entry name" value="RhaS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46847:SF4">
        <property type="entry name" value="PTHR46847:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02637">
        <property type="entry name" value="RhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295517" description="Autoinducer 2-binding protein LsrB" evidence="8">
        <location>
            <begin position="40"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="9">
        <location>
            <begin position="67"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG80240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="38865" checksum="AC91AFE06AFFD88A" modified="2017-01-18" version="1">MKQRPFARLRAPRSLAAMATAGVMALALTACGGTTKDSASNSGSGDAGSGASASANPNAPIKEGLKIAFLPKQINNPYSTIVDKSGIDAAKEYKGEAKEVGPSDASASSQVSYINTLIQQRQDAILVAANDPNAVCGPLKQARSRGIKVIAYDSDTNPDCRDIFINQASSEEVGRSQVKLLSELMDGKGEFAVLSATANATNQNTWIKFMQEELKKPEYSGMKLVKIAYGDDDDQKSFQQTQGLLQAYPNLKGIIAPTTVGIAAAARYISGSKYKGKVVVTGLGTPNQMRQFIKDGTVTKFQLWNPKDLGYLSSYAAAALASGQITGAQGETLKAGRLGERTIGANGEIVLGPPFTFEKSNIDEFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4T3</accession>
    <name>A0A1H6D4T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Broad specificity phosphatase PhoE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80379">
        <property type="protein sequence ID" value="SEG80379"/>
        <property type="gene ID" value="SAMN04489712_11371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="244" mass="27169" checksum="322B855ABEA72E16" modified="2017-01-18" version="1">MAGVRNLESLILTRHGESTGNLAHQAARDAPGDRIEEVDLCDRDADVPLSERGRLQAVALGRRLAALPPSERPTAVVSSPYVRSLDTARIALAELQDPPDLLVDERLRDREMGVLYRLTPHGVRVRYPEEAERSRRLGKFYYRPPGGESWADMLLRLRSAYLDIDLDHPGGRVLVVVHDAVVVLTRYIVEGLSERELMEIERTPIGNCSFTRWVRRDGVLRPAEYNDTAHLSEPAGAPAPTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6R5</accession>
    <name>A0A1H6D6R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80425">
        <property type="protein sequence ID" value="SEG80425"/>
        <property type="gene ID" value="SAMN04489712_11378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="1">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="22835" checksum="A10A87CCCD215ECA" modified="2017-01-18" version="1">MPRSPGATRIGTGEIVAARKLVTVHGEPVAVPDPGRLVHLQFRRFAGCPVCNLHLRGVVRRHEEIAAAGVREVVVFHSAADELRVHAADLPFAVIADPGKRLYAEFGVEEGRRALLRPRAWWPIVRALAVASARVLLRRQAAPSVNPEGGRYGLPADFLIAGDGRVLAVKYGEHVYDQWPVEEILRLARAHASDRTAHADDDAPAGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7E7</accession>
    <name>A0A1H6D7E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80645">
        <property type="protein sequence ID" value="SEG80645"/>
        <property type="gene ID" value="SAMN04489712_113121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="50" mass="5413" checksum="38E93B31C570257B" modified="2017-01-18" version="1">MVPSPSPTVRLQQVQRPTVPERRRNPMGTVLVIVVLAVAIACGTVLAFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7P6</accession>
    <name>A0A1H6D7P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81311">
        <property type="protein sequence ID" value="SEG81311"/>
        <property type="gene ID" value="SAMN04489712_11423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="119"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="247" mass="27360" checksum="BB4EBCBD018EF78E" modified="2017-01-18" version="1">MELACGDPGEAARFYGALFDWRLEPQEYEGYGRFLRDGKIAAGLWPEKTSGAAASWTVYFTVEDVEASADLVRDAGGQVVVEPRELDGQGTLAGCLDPEGVFFMLWKSANWGCTELLGRPGCWGWTDLFTRDPERAEDFYPRVFGWGRSRGGDRVHWTVEGQVVAGMLPISPEAPAEALSAWFVHFAVTDVWEAAERAEALGAVRIKQFHDPLHGPAIILTDPQLAQFVLISVPPQETKGRFPLLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8R8</accession>
    <name>A0A1H6D8R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNARE associated Golgi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_114102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81632">
        <property type="protein sequence ID" value="SEG81632"/>
        <property type="gene ID" value="SAMN04489712_114102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG81632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="23483" checksum="9AA8C80A909DE6D7" modified="2017-01-18" version="1">MPSSITGWLGGLSGPVVYGVVAALVFCEDALFFGFVVPGETAVVVGGALAGHGEVSVWWLAAVVVLAAVTGDSVGYEIGRRFGPVLLTVRPLRSHLDRVEAARNFYRRRGAMAVFLGRFVAFLRAMVPALAGISGMRYRTFLVFNALGGLIWGVGFTLLGYFVGAAYGRIEHLVGRAAAGLTATVAIIAFLLWRLRHHRSTKNAGKKAREEDRTGFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEK7</accession>
    <name>A0A1H6DEK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83651">
        <property type="protein sequence ID" value="SEG83651"/>
        <property type="gene ID" value="SAMN04489712_11642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="129"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="376" mass="39985" checksum="2D5F343D8AD15F9D" modified="2017-01-18" version="1">MRIGIIGGGPGGLYTAVLAKRLDPRHEVVVWERDAADRTYGFGVIFSDPALEVIGRADPRTRAALEPWLVRWNRMSVHHRGEAFTTAGLGFAAIARVSLLAVLRRWCLRSGVTVLHGRPAPPLERLAAECDLVVAADGAHSATRTGRAGRFGTTLRPCALRYAWLGADRAFDGMSFMIAETAGGPVVAHAYPYADGRSTFLVEARADAAPAQESVQAPAVDRIARLFGEHLGGASLTAGRSRWSRFAVVRNRTWWDGNVVLLGDAAHTTHYSIGSGTALAMGDAVALTTALREHSGLPAALAAYEAARRPVAERMQQVAQASLEWFEGIDAELAAGLPGLATALFTRGGRVSLADVRDLEDPADVTGPLRAVAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF15</accession>
    <name>A0A1H6DF15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_116116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83978">
        <property type="protein sequence ID" value="SEG83978"/>
        <property type="gene ID" value="SAMN04489712_116116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00937">
        <property type="entry name" value="2A51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG83978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="41691" checksum="C0FC82DFB4B290C6" modified="2017-01-18" version="1">MTTSPGPEHGPGSGEGPDSGHGRERPARPLRELAALFLKLGVIGFGGPAAHIAMMHEEVVRRRRWVDERRFVDLIGAVSLIPGPNSTELAIHLGYERGRWRGLLVAGVCFIVPAVVMVSTLAWAYVRYGSTPEAEGLLYGIKPVVVGIIAWALVGLLRTAVRGPLLWCVALAALAAYLAGANELAVLAAGGLAVTAWRTAARLRDGRAAVLPLLLAAPHDERLPQLFWTMLKIGSVLYGSGYVLLAFLRGDFVERLGWLTEQQLLDAVSIGQVTPGPLFTTATFVGYLAAGWPGAVLATVGIFLPSFALVALLTRLAARMRSARWSAALLDGVNATALALMAGVSYQLGREALVDPLTVVLAVATVLLLWRVRLNSAWLIGVGGAIGLAVRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJJ6</accession>
    <name>A0A1H6DJJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_1189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85460">
        <property type="protein sequence ID" value="SEG85460"/>
        <property type="gene ID" value="SAMN04489712_1189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="67"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG85460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="25195" checksum="6ED4C97C7C2DDB7D" modified="2017-01-18" version="1">MDTHVSCPTNGVRGDTGQGAATVRTDDARRPEPATGRETEAAMAFDERTEELAVKAAQGDQNALNELLRRIEPDVMRHSARFLPCRQDAEEACQDALLQVARNIHRFEGRSRFSTWLHVVVANSARSTYRSLKRRSVEQAGELPQQRPDPRRTSVIAGSRVDILDAMENLEARKPDLIQALVLRDISQLEYAEIAEQLGLPLGTVKSRIHEARKQVRQTLGESYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKS1</accession>
    <name>A0A1H6DKS1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_118101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85892">
        <property type="protein sequence ID" value="SEG85892"/>
        <property type="gene ID" value="SAMN04489712_118101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="13831" checksum="687FAC17F37E8DCF" modified="2017-01-18" version="1">MPIQLSRIVVFARDKRESARFLADLLGLDEPKSVGAFTAVRLGDGVTLHYAQPGADFPRQRYTFLVGDADFDSIFARIREWGLPYWADPYRRRMGELDTQGGGRRLYLDDPSGHGLEITTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DR47</accession>
    <name>A0A1H6DR47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87877">
        <property type="protein sequence ID" value="SEG87877"/>
        <property type="gene ID" value="SAMN04489712_12124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="29495" checksum="08554E4D4EFBF026" modified="2017-01-18" version="1">MTDTPPSVDLRTDEPHPARVYDFYLGGKNHFGADREFGQRILGICPQLRPLAQANRRFLARSVCLLARDYGIRQFLDLGTGLPTSPNLHEVAQSIAPDSRVVYVDNDPIVLTHARALLTSRPEGATDYIDSDVVDIDRVVQQAARTLDFRRPIAVSALALFHFLPDPQPADLLAYLRSRLAPGSFLTISHVLPALREVAKAYQGTMGLGTLRDRDEITALFGDFELLEPGLVEPYRWRPELEPGEQEPGDEIADLGACAVARKPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT99</accession>
    <name>A0A1H6DT99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl diphosphate synthase, type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88460">
        <property type="protein sequence ID" value="SEG88460"/>
        <property type="gene ID" value="SAMN04489712_1227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="329" mass="35621" checksum="20FA9757BC08D171" modified="2017-01-18" version="1">MSDLRVRVDRTLEKFVESEVAALVALEAELAPVAEQARVSVAGGKRIRPAFCYWGWRAAGQPDAEPMVRAAASLELVHAAAIVHDDIIDRSPLRRGRATAHERLGDSLAIMIGDLLLTWAGELFHTSGLPRTFLARAVSAWTAMGRELIAGECLEILRTGAAPDVSRSMQVVRFKTGSYTIEWPLRIGAVLGGAAPAVLEALAAYARPLGEAFQLRDDLWGVFGDPADTGKSSLDDLAGRKPTALLALTLERACAEDRARLQELLRAPIQDAEAARIRQIMRRSGTPDQVRQMIDDRAAAARAALERVRLPPEAQGALTRLINEVTADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTT4</accession>
    <name>A0A1H6DTT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding transcriptional regulator, FadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88688">
        <property type="protein sequence ID" value="SEG88688"/>
        <property type="gene ID" value="SAMN04489712_12259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG88688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="28601" checksum="D9C4354F7650710A" modified="2017-01-18" version="1">MALPESKAGRGLSAALPSDGVRPPKTGELVARRLRRMIVEGSLSDGDYLPNEATLMEHFGVSRPTLREAFRVLESEGLIELRRGSRTGARVRVPGPEAVARPAGLLLQLGKATLGDVYVARSAIEPPAARLLALSGDEQRYAALEEELELERANLGNAEQFAIGSARFHLRLVELSGNRTLALMAGMVHEIILRQTQASVRASEATGTPGDYDRALRAYEKLVRLVRAGDGDAAEKFWHKHLQLADELVLAGREATQIIDILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVP4</accession>
    <name>A0A1H6DVP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ethylbenzene dioxygenase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88823">
        <property type="protein sequence ID" value="SEG88823"/>
        <property type="gene ID" value="SAMN04489712_12287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
        <property type="entry name" value="ring_hydroxylating_dioxygenases_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="174" mass="20026" checksum="E5960FF4136F3B1C" modified="2017-01-18" version="1">MGTGVRVRVGSALHSEVVEWMDAEAELLDDYREREWLEGMVSRDIVYQVPLRQTVERARGMGFLEGTFHLDETYGSLQSRVARNETAYAWAEDPPSRIRHFVTNIKVTDEGDGLVGVRSNLLIFRTRQDQTQPQLLSGERKDTLRREDGTLRLLHRRVLLDLTVIGTHNLSIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX42</accession>
    <name>A0A1H6DX42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purD</name>
        <name evidence="9" type="ORF">SAMN04489712_12458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89769">
        <property type="protein sequence ID" value="SEG89769"/>
        <property type="gene ID" value="SAMN04489712_12458"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="107"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG89769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="415" mass="43084" checksum="51674DA8B828A454" modified="2017-01-18" version="1">MRILVLGSGGREHAIARALHLDPVVTALHVAPGNAGTLEIAHNHVLDPTDPVAVTELAARLRPELVVIGPEAPLTTGVADALRQAGVPVFGPDRAAARIEGSKAFAKEIMAAAGVPTADSRVCESSREVDEALDAFGPPYVVKDDGLAAGKGVVVTEDRDEAVRHAASCGRVVIEDFLDGPEVSLFALSDGNSAVPLLPAQDFKRAYDGDRGPNTGGMGAYTPLPWAPPGLVDEVMATVVQPTIDELRRRETPYVGVLYAGLALTSRGVRVVEFNARFGDPETQVVLDRLATPLAGLLQACAIGGLDPATRLEWHPGAAVTVVVAAENYPASPVKGDVIEGLAEAAAVPGAYVLHAGTKLDEEGRVVANGGRVLNVVGTGPDLAAARATAYDAAFKIRLRGSHHRTDIALQASQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY27</accession>
    <name>A0A1H6DY27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (NDP forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90141">
        <property type="protein sequence ID" value="SEG90141"/>
        <property type="gene ID" value="SAMN04489712_12550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="486"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="701" mass="71835" checksum="8EF5B3FA217F3665" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ06</accession>
    <name>A0A1H6DZ06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90053">
        <property type="protein sequence ID" value="SEG90053"/>
        <property type="gene ID" value="SAMN04489712_12525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296375" evidence="1">
        <location>
            <begin position="29"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="25939" checksum="184EE5BD49EEA4F7" modified="2017-01-18" version="1">MDLGLTGRVALVAAASSGLGLAVARTFAAEGAHVAICARDPERLARAHAEIDACGPGRVLSTSVDLTDDDAAGAWVRDTAAEMGALHIVVTNSGGVPHGPVDAFDTAVYREALTGNTIPHVAVALAALPFLTEAGWGRILMITSEAVRQPLGATGLSAVARLGVLGFAKGLVDSLGARGVTVNVLAPGFHRTKALDEQFGEDVEQAVAEVAKGLPLGRVGRAEDFGALVAFLASEQASFVTGTVLLVDGGNTRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZR6</accession>
    <name>A0A1H6DZR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltooligosyl trehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90807">
        <property type="protein sequence ID" value="SEG90807"/>
        <property type="gene ID" value="SAMN04489712_12744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013797">
        <property type="entry name" value="Maltooligo_trehalose_synth_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="33"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="776" mass="86001" checksum="55F72D54ABE2B743" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E080</accession>
    <name>A0A1H6E080_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91000">
        <property type="protein sequence ID" value="SEG91000"/>
        <property type="gene ID" value="SAMN04489712_12811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="11"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="7622" checksum="51585F68584DE47E" modified="2017-01-18" version="1">MKQSNRQNEKLTVAEVCAELKIARSTFYDWRAKGLAPKCTRIPNGDLRILRADLDEWWNSLQETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0J5</accession>
    <name>A0A1H6E0J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90673">
        <property type="protein sequence ID" value="SEG90673"/>
        <property type="gene ID" value="SAMN04489712_1275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="161" mass="17017" checksum="B8C5529D14975C67" modified="2017-01-18" version="1">MTTPPLNRTLLTTEPIATFTSYADAQQAVDRLSDLHFPVERTVIVGVDLRMVEQVLGRLTVLRAAGAGAASGAWFGLLIGLFFAIFTPGRLSSVGVILAGLVWGVVAGALFGAVSHALTGGRRDFVSRSSFVAATYEVRAEAEYAARAREMLESGTDARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1S3</accession>
    <name>A0A1H6E1S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90875">
        <property type="protein sequence ID" value="SEG90875"/>
        <property type="gene ID" value="SAMN04489712_12764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="28878" checksum="A3888CED37EEAB1C" modified="2017-01-18" version="1">MSAPSEAEGTRSRRTATIADVRALGQPPGLKERRNEEHWAGRLYMRSLSPFFSWLSLRLGLSPNQLTYLMMFTGVAAGVVVSVPGHPLWAALAGALLVQVYLLLDCVDGEVARYLRQTSVAGVYLDRIGHYLAEVALLIGLGARAQGGWESGGYLELGLVAALGAALIKAETDNVVVARAKSGLPADPAAGDRALRPRSTGLALARQAASAVRLHRIIGAVELSLLIALAAVIDVLTGAQTPVTTRVLTVVVAAVAAVQTLLHLVSVIASRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E239</accession>
    <name>A0A1H6E239_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91204">
        <property type="protein sequence ID" value="SEG91204"/>
        <property type="gene ID" value="SAMN04489712_12861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core3" evidence="1">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="15769" checksum="A127F6A5BA581439" modified="2017-01-18" version="1">MTVSDALNRPPGVPTRHRMAARVAVGLAFGLALLPSGRLHAVLTRISRGAAPAGYEQAKAARDAVLAVSLACLGSRGCLPRSLATALLCRMWGVWPTWCVGARTRPPFGAHAWVEAEGRMVGEDASEGYLNTLISVPPTEPGRRAGTSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2Q6</accession>
    <name>A0A1H6E2Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase components of ABC transporters with duplicated ATPase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91266">
        <property type="protein sequence ID" value="SEG91266"/>
        <property type="gene ID" value="SAMN04489712_12876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="317"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="355"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="526" mass="56964" checksum="9C4AEB9C48A43917" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2R5</accession>
    <name>A0A1H6E2R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rod shape-determining protein MreB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91195">
        <property type="protein sequence ID" value="SEG91195"/>
        <property type="gene ID" value="SAMN04489712_12859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="354" mass="37179" checksum="73E0242263FCEC20" modified="2017-01-18" version="1">MSLRDFPCRDTTVDLGSRTARVHVRGRGVLAVPSLLATSAQTGGFLAAGEKALAIRAQTPGDVLFSWPFEGGVPADPQAVQWLLRHLLRIAHRRRYLANPRLALAVPSQITDVQLRALSAAATSVGARWLAMVPVPLAAAIGAGLPLDEPRAVMVVDLGAVVTDIAVMSLGSIAAARTVRVGGQDLDEAIARHVREEKGVLLGADVAATLKARFGAGPQRGFASAPFLVHGRDSDNGLPRPVMLSPADVTAAVSGPLDTLMEAIRTTLAACPPDMVCDLARDGVTLTGGGARLAGLTALVQARTGLPARVAGDDPANVVVLGAAELLEHARDFRRRRVPHRDRRQGFMAAPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4Z6</accession>
    <name>A0A1H6E4Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92289">
        <property type="protein sequence ID" value="SEG92289"/>
        <property type="gene ID" value="SAMN04489712_1336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296549" evidence="1">
        <location>
            <begin position="29"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="29674" checksum="B9D8C753B4F14E56" modified="2017-01-18" version="1">MQSSKQRKSIAGTLLKLLGSKSRPVAPASGDGEVVQPAAGEGALENHLGGDEARNYRKYEYDMVAPHVGRSLLEVGSGLGHFSEQFAGRLDYLVVSDNDPYCVGQLRERYEGNPDVEVIDLALPTDIKIRQKVDTVVMMNVLEHIKDDVQALRDLAAVTLPGGRIVIWVPGYMQLYGDFDRKVGHVTRYTPATLTRSVRAAGLVPEVCKPINFLGGIAWWAAVRRGGAGYPDPRLVKIYDRTVVPTTRAIERLVRPPFGQTVFCVARVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5X2</accession>
    <name>A0A1H6E5X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted Zn-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93092">
        <property type="protein sequence ID" value="SEG93092"/>
        <property type="gene ID" value="SAMN04489712_13710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="45"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="191"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="452" mass="47068" checksum="B580F19F5E84BBCE" modified="2017-01-18" version="1">MTTLIPDFPARPVPGPIPPWAFPTGTEGQIPGGPATLRCDLPGRRLAAVRLVLDAGAGREPDGLDGVATLTSRALLEGTEPGGGTRLAAHFERIGASLHAFADLTALRVWLDAPVTRLGEALELLAEVLGGPALADSDVRRLVRERLEEIAQEDADPGSRAMRELRARLFPDHSRPARPTGGSPDSVERLTGADVRAFFAAASPAEATAVIAGDLTGVAAEDLLTSAFGGWRTTAAPLPAPDTTPPTPGPRLVVVDRPGSVQSYLAIGHGVPGRAHPDWPTLTVACHVLGGGLTSRLNALLREEKGYTYGMRAGLLRMRHCGVFIAQGAVHTEVTADAVTDALGALRSVLDGVGDGECRASVSALADRAPADYETSRAVASELADAAASGLGVDYPRRYLDELRAVTPERIVRAYAEHVSQDALTVVVVGDAGKIRGPLEDLGQGSVTVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6R8</accession>
    <name>A0A1H6E6R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93337">
        <property type="protein sequence ID" value="SEG93337"/>
        <property type="gene ID" value="SAMN04489712_13824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="71" mass="7611" checksum="E6042A5542C3A090" modified="2017-01-18" version="1">MFNAIVLLAVFLAGGALGVFAMLLAGIRAEERHMSLRGTPGTRTRSATRRVLGVHVYEPAEPAAARHAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E935</accession>
    <name>A0A1H6E935_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent oxidoreductase, nitroreductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000044">
        <property type="protein sequence ID" value="SEG94222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94222">
        <property type="protein sequence ID" value="SEG94222"/>
        <property type="gene ID" value="SAMN04489712_14415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="15957" checksum="28EA10E2909C84D9" modified="2017-01-18" version="1">MDPAVRRAIEFTPAATTRERIIDITTTGRRTGIPRRIEIFFYRAHGETYLCSGPQGRPTDWYANLLTHPDFTFHLKYGVKADLRARAIPVTDPAERRRVLTEIVADLNQPHNPGTIPQPTHLEDWLDSRLAKITFPGPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E979</accession>
    <name>A0A1H6E979_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthetase component 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94310">
        <property type="protein sequence ID" value="SEG94310"/>
        <property type="gene ID" value="SAMN04489712_1465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="72"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="35607" checksum="4A457A4A18B37699" modified="2017-01-18" version="1">MREAFAHAGGMLATGLAEVTSDLAALDSGGWWAVVVTYEGKVTCARFTDVRPAPPPRAPWRPPGEWRSSLDEAAYVAGVRRIRDAIADGIVYQANLCRVLSAPLPDGADLAGLGALLARGNPAPYAMTLRVPGLQVACASPELYLSRDGDVVESRPIKGTGRTAADLLPKDHAENVMIVDLVRNDLGRVAETGSVRVPALCALEEHPGLVHLVSTVRARLRPGIGWPELVAATFPPGSVTGAPKASALTLLDLLEPVPRGPYCGAVGWVDGRTRRGALAVGIRTFWAEEGLLKFGTGAGITWGSDPVREWRETELKAARLLEVAAGEDLGQRGAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECH8</accession>
    <name>A0A1H6ECH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000057">
        <property type="protein sequence ID" value="SEG94973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94973">
        <property type="protein sequence ID" value="SEG94973"/>
        <property type="gene ID" value="SAMN04489712_1571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="33207" checksum="EFC3FF4D38C4E146" modified="2017-01-18" version="1" fragment="single">ATETGGKVTATDWQVGVALGLTSLLGIGLLELTIALKQRAAGGRSAAEIRQSLIRRICYPRLSAQAAAIAAARGIDAEAAWRAAWIDRYGIGPDSTRRERRTARKILARQRKADRRAAKAGALSIDGDTIVRRAGERPEPTIPAPPVSADDERPPGERPELERPVTARDPQVREWAVSSEAAEGIAAMEEWLSAQASAPGTLRELPPGERPDGERAEGERSPEDSVSAQDRPTRERPKRRLRRKVSARDDDAQDEAARRLEAVRNLLSAQPDMSGADIATALSIPPSTARRLRARVLRERKGGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S8R8</accession>
    <name>A0A1H5S8R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46850">
        <property type="protein sequence ID" value="SEF46850"/>
        <property type="gene ID" value="SAMN04489712_101114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF46850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="25953" checksum="5023B2907F0B82BF" modified="2017-01-18" version="1">MTTVRALSYNIRSLRDDRAALMRVIRACDADLVCLQEAPRLLNWRARRRALAARTGLTPAAGRRPAGLAVLAGPRARRVHAEYHLLTRIPGLHRRGLALAVLEIDGARVIAACTHLDLAEDARRTHTAEVIGLLERARRRFQAPVVLGGDINEEPGGPSWDLLTSVFTDAYAAAPRGPAPTFSARRPRRRIDAIFTDPGIEVIGCGVPSDAAPPADYTRATDHLPVLADLRLPNEPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SDA5</accession>
    <name>A0A1H5SDA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47811">
        <property type="protein sequence ID" value="SEF47811"/>
        <property type="gene ID" value="SAMN04489712_101142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF47811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="32517" checksum="7AE5975E569EC0CC" modified="2017-01-18" version="1">MQPETVPLGPDDPRRLGGRVLLGRLGEGGQGVVYLGRGKDGELAAVKLLRGGQSATPRARSRFAREVAAARQVAGPHTARVLAARVSGARPYIISEYVPGPSLQEIVAERGPLPQERLHKVALRTARALAAIHRAGVVHRDFKPGHVLLAKGGAKVIDFGIARAPDSAAITTGPVGTPAYMAPEQIEDEPVGPPADVFAWGATMVYAATGRPPFGSGSNAAIMRRVTSRPPDLGDLPEPLRGLVVRCLDKNPAARPTAPQLVRALREGRAPAPEPRPQSIPRYRWRMMVALAVVVVAGFTVGVLLPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SER4</accession>
    <name>A0A1H5SER4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49069">
        <property type="protein sequence ID" value="SEF49069"/>
        <property type="gene ID" value="SAMN04489712_101179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045713">
        <property type="entry name" value="DUF6069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19545">
        <property type="entry name" value="DUF6069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="15084" checksum="9EF0D254D3D51EE7" modified="2017-01-18" version="1">MAVSATPVPTAPAAWRRRAQGVAVLGATLAAVVVWLVAAPLFGQDLVVQQPGREAIEVGFGAVVTFSLVPSLAGWALLFLLERLTARARVIWTVIASAVLVLSFGPVLGVEAAGTTKLTLALLHLAVGAVLIPIFWRTARTPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SNB0</accession>
    <name>A0A1H5SNB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative spermidine/putrescine transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52015">
        <property type="protein sequence ID" value="SEF52015"/>
        <property type="gene ID" value="SAMN04489712_101288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284223" evidence="1">
        <location>
            <begin position="31"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF52015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="370" mass="39203" checksum="52DEB74FB71E3FCD" modified="2017-01-18" version="1">MNKSHVLRLAAAAAAVTMAAACGGGSGSGADVDLGTGPAKAGSVKKDALKGVNLTFVSYGGVYQSGQEKAAVEPFAAESGARVLSDGPTDYAKIKAQVDSGNVTWDVVDTDAIWGESQCGKLLAPLDYSIIDKSNVPEGLAGECTVPAMQYGMVLAYNKDKYGANPPQGWADFFDTAKFPGKRAIPGIANDAAPGPYEAALVADGVAPDQLFPLDVERANKKLTSIRPNLVFWKTGAESQQLLESGEADMVMLWSGRAYDAIKNGAKYEVQWNQFMPIMDVLAVPKGARNPKAAMALINYYLGAQQQAKLTELTSYSPIHTGAQPTLDPLGTAFLTTSPERSKQALKIDAKWWAANQHALIEKWSAWLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SPJ9</accession>
    <name>A0A1H5SPJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein SAMN04489712_101275</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51687">
        <property type="protein sequence ID" value="SEF51687"/>
        <property type="gene ID" value="SAMN04489712_101275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF51687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="9295" checksum="BEA17AC6A8F6CF99" modified="2017-01-18" version="1">MAVRVAIRVGPGASRTRVGGVYGDALVVKVTARPVEGKATEAALRAVADALGVRRRDVQLVSGATGRDKVVEVTGDEAAIREKINGLRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SZN3</accession>
    <name>A0A1H5SZN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55989">
        <property type="protein sequence ID" value="SEF55989"/>
        <property type="gene ID" value="SAMN04489712_101425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF55989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="44171" checksum="A1ED0D583BEB2D38" modified="2017-01-18" version="1">MATQSFAEAIAEAEQIIRSAPHVHTEQDLAEGLDYLAGSIKSCLHLAWAYERDFPFFVASTGPYAKLGLDNPDTLYFHAYLRDDAEYVVTGRRGTTADLSFQVLNGDYSPARSPDSLTAFDDRDIEIAPDGTYELRFGPEPASSRPNYFTLGPGSAMLIAREVYSDWDSERRGEIRIHRAGALGAAPPPVTTEQMAKRYDVAGRMLISRLRTFLAFPEWHYLKLPVNTMTEPRPTPGGLATQYSSVGHYDLDDDQVMIIAVPAAARADAPYQGFQLGSRWYISLDYINHQTSLTADQARVDPDGKIRFVVSERDPGLANWIERTGHRRGYLQIRWQRLARELKPEDGPEVEIVPFDELPQRLPHYERQRVSPQEWADRIAARQVAVAKRMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T6I9</accession>
    <name>A0A1H5T6I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR C-terminal helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57721">
        <property type="protein sequence ID" value="SEF57721"/>
        <property type="gene ID" value="SAMN04489712_101481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="334"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF57721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="44331" checksum="8C1180FE6760A492" modified="2017-01-18" version="1">MFQTPVSPGPWQELPFVVVDILRPGIPQLADEMVEALRVSVPELGIPESVVGRKGTRTLIEGGLGRFLDRIASPVTPLPLHLDLARMLGEAEFHSGRSLDVLQAAYRVAARTMWRRFSTLGMEAGLCSDQLCALAEAVFVVTEEAADQSARSYAALAGQAGVSQQRQRERLLELLIGEGAFPEERIRESAVRAKWRIPDTVACVALDEPWQDHHLLSPAVGPDVLMDLRPPGPFVLVPDPDGPGRLDMLTRAFDSMLISVGPSVPLSQARLSLRLARRALSLARRGLIAAAGPIMSDRHLPTLLIFGDEDVVRLMERGGWDRLAALPPGRRGPLAETLRCYLSRGGSAPDLGARLNVHPQTVRYRMARLEHMYGDSLQDPEWRFRMQIVMHMHEIMGRGGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TBM6</accession>
    <name>A0A1H5TBM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59578">
        <property type="protein sequence ID" value="SEF59578"/>
        <property type="gene ID" value="SAMN04489712_101539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284835" evidence="3">
        <location>
            <begin position="47"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF59578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="36357" checksum="E11A8743F5C8C4FF" modified="2017-01-18" version="1">MAAFDPAGGGRNPRRSPRRRAVWKRSAVIALVVAMGALAPAPGAGALPTAPKDTEKELAKLKKQSDRLTKEYRGELIALKEAEKAAERATADAERLDKEWRASRTLIGRLAATSYMNGGLEPMALFGATDPGAMIRDAAMIEHLNINNGRRVQNLQQLAAQAGRSRKTAETKVAEVREQIEDLESQRGRVKKLLAKYQPEQPSSGGGRPDGVRGTKSPIVGNSMTSRMRSVLLAIDGKYGPFPTIGCYRAGDPQDHGSGQACDFMESTGGAMPSANARAHGDAVAQYATSNASSLGIKYVIWRQRIWDVRSGGGWRAMEDRGSVTANHYDHVHISVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TGN1</accession>
    <name>A0A1H5TGN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61167">
        <property type="protein sequence ID" value="SEF61167"/>
        <property type="gene ID" value="SAMN04489712_101586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF61167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="21860" checksum="6FEA6113C53CC020" modified="2017-01-18" version="1">MSTRDPDRRRALLEAADRVIRLEGPGASMAAIAAEAGISKPILYRHFGDKSGLYQALAERHTRRLVEAILEGFHGPGSERDRIRSTIDTYLAIISENLQLYRFLMHRASAEDAATHSAMSTMIRGLSQELAKVLMAESELADPARAYVWGHAVIGMVQTAGDWWLDHPEVSRATVVDALADLILVGLPAASAPPPGVPVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TQB3</accession>
    <name>A0A1H5TQB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64984">
        <property type="protein sequence ID" value="SEF64984"/>
        <property type="gene ID" value="SAMN04489712_101708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF64984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="31" mass="3391" checksum="5014DC293EDD4BBC" modified="2017-01-18" version="1">MSSSMFRSPSTPIRNDSGNPKLPVRKEGKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TQI4</accession>
    <name>A0A1H5TQI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65046">
        <property type="protein sequence ID" value="SEF65046"/>
        <property type="gene ID" value="SAMN04489712_101710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF65046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="713" mass="76910" checksum="627AD44E95B4208C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TSZ2</accession>
    <name>A0A1H5TSZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65945">
        <property type="protein sequence ID" value="SEF65945"/>
        <property type="gene ID" value="SAMN04489712_101735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF65945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="160" mass="17274" checksum="8121F41AC96C2CB7" modified="2017-01-18" version="1">MSIPAEGPPLAAVYADVQQFYARHMHLLDAGAADEWAATFTEDGVFAPPSAPEPVRGRANLAAGVRESFAKLTAAGEVHRHLLSMVTVEPQPDGSLHVRSYAQVIATPRDGAARLHLMCVCADVLVRVDGELRVRERRVTRDDRPDLQPASGTDGRADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V8U9</accession>
    <name>A0A1H5V8U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83640">
        <property type="protein sequence ID" value="SEF83640"/>
        <property type="gene ID" value="SAMN04489712_102214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="78"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF83640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="502" mass="52588" checksum="B53FDFF76AC7002A" modified="2017-01-18" version="1">MERRRFLTVAGLAGLAAGCTDESPASVPSPTVEATGGAVTPTGPADWEALGRGLAGRLVRPGDDAYDEARKLYIPRFDRVRPAGVAYCAGPEDVSECVAFARRQRLSVAVRCGGHNYAGWSTGGGLVIDVSPMNAVQAGGGRATVGAGARLIDVYKGLTDRGVAVPAGTCPTVGIAGLALGGGIGVVSRRHGLTCDVLEAVRVVTADGRVRDCDARRDADLYWACRGGGGGNFGVAVQFVFRTHPAAEVTLFSLRWPWPRAAQVVGGWQSWAPYAPDELWSGLQINTDPSAGTPTVDVTGAAFGDPDAHLDRLTAAVGADPAFRSVDTHSYLEAMRRVGGCADGGIAACHRAGTLPGGRPDGRYPRTEYTAKSHVATRPLTGSAIEALTGRFTGGNGVAGRSVLLDALGGAVGRVRPGDTAFPHRNALFTVQYLAGTGDRGWLRDVHGAMERHLGGAAYVNYVDPELRGWQRAYYGGNYERLVRVKNAYDPDGLFTFPQSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V9N4</accession>
    <name>A0A1H5V9N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83930">
        <property type="protein sequence ID" value="SEF83930"/>
        <property type="gene ID" value="SAMN04489712_102224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF83930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="449" mass="50898" checksum="2EF975256191BE8E" modified="2017-01-18" version="1">MSSILAPPPPGSDLKPVLGAPGVPLIGNTIQTMRDPFTMARKRYLRFGPVTWGWLLGQRTVTVQGPEAAETVLVNKDKAFANGPAWTYYIGPFFTRGIMLLDFEEHLHHRRIMQQAFTKPKLRTYLETMAPGIERGVGAWRPGTGFTFYDHIKQLTLDLATDVFMGVELDPREADRINGAFIDAVRAGTAYVRFPVPGLRWHRGLRARKVLEEFFRRHLPAKRRDGGDDLFAALCQAETDDGHRFTDDDVVNHMIFALMAAHDTSTITMTTMAYYLARHPEWQERVREESRALGKAVPEFDDLDRLVSLDLVMKEAMRLVSPVPALPRRTVKDTSVLGYHIPKGTTVVVPTLTNHHMPEVWKDPERFDPERFAEGRREDKSHKYAWAPFGGGAHKCIGLHFAGLQIKSVFHQVLLNFRWSVPDGYQWPLDTTSLPSPKDGLPVRLERLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VBC5</accession>
    <name>A0A1H5VBC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted metal-dependent phosphohydrolase, HD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84672">
        <property type="protein sequence ID" value="SEF84672"/>
        <property type="gene ID" value="SAMN04489712_102252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="entry name" value="PTHR21174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035170">
        <property type="entry name" value="HD_phosphohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF84672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="213" mass="23752" checksum="2D2685D39465C304" modified="2017-01-18" version="1">MSERDSRELVERWVALAGEETRGIGADLVARYGEPHRRYHTRDHLTAVLDLVDELAAYADDPDAVRLAVWFHDAVYDPERGDNEERSAVKAERVLADTDLPPATIAEVARLVRLTAAHDPGPGDRNGQVLCDADLAILAADPEKYAAYTAAVREEYAFVPDEYFTTARADILRSLLALPALFHTPPARERFEQQARHNLQTELMLLEAGSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W5J7</accession>
    <name>A0A1H5W5J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94784">
        <property type="protein sequence ID" value="SEF94784"/>
        <property type="gene ID" value="SAMN04489712_102597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF94784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="76" mass="8375" checksum="2D01F54054EEB50D" modified="2017-01-18" version="1">MGNPLNRLADWALAQFMPRGEASAAMCDPPICGCWYRTCYCRNSKAYQKLCDGGCNGIPVFCQADSACRHINTYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W9X8</accession>
    <name>A0A1H5W9X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane domain of glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96359">
        <property type="protein sequence ID" value="SEF96359"/>
        <property type="gene ID" value="SAMN04489712_102644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018476">
        <property type="entry name" value="GlyceroP-diester-Pdiesterase_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10110">
        <property type="entry name" value="GPDPase_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="GPDPase_memb" evidence="3">
        <location>
            <begin position="236"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF96359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="489" mass="50293" checksum="A39705867D57B69F" modified="2017-01-18" version="1">MSGPQAWTAPGSAVPSGGSSERAGVGAPDHGTSPGGASGAVPAAGEGGPGTAPAPGGSGTPAADRAELLGGEIPFRPLGVAEILDASIACIRRNPRAVLGLSVLITGIVQVLNTVAGYLLLGDRAQEELTPEPLMRSVGAQFTLGLMSLLMSAYGTLLLAGLLGPVVSRTLFGLPASLRQVWRDTRPAFVRLLGTAAVALVLSMLGAVLPLLPFVLLLAGDGPPAAGVLAALFGFPVALVLMVWLYVLWVLALPAVVLERRTVAGALRRAYQLSRRGWWRTCGTLLLALLITIFMGFLALRLPFLFLQLLLFSGEGGSGALLGSLAMDTLGRIVSWSLMTPFDAGVIALLYVDRRMRREGFDLDVQTRGRPGAAGVSPGGDPDHPLDIWRPVEFPPVSGFPPPSFPPPVPPPPAHGPQPQGRPAWPQTAPPGQTASSGQATPLGQTAPPGQTAPPGQTASPGQTAPGGFAAWPGMPQPPHPPAGDGRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WBW0</accession>
    <name>A0A1H5WBW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96945">
        <property type="protein sequence ID" value="SEF96945"/>
        <property type="gene ID" value="SAMN04489712_102660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="289"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF96945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="524" mass="55811" checksum="8261FD09A9FCC157" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XJT4</accession>
    <name>A0A1H5XJT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03083 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12044">
        <property type="protein sequence ID" value="SEG12044"/>
        <property type="gene ID" value="SAMN04489712_103289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG12044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="21654" checksum="62E3B2582F9F5847" modified="2017-01-18" version="1">MRFALEDELRAERFRLIETLEGLSDDDFDAGATLCTEWAPRDVLGHVIGIDYLLGSYVPYGTRINAANRAQADRARMLPRGRLMEWARHWAANPSLTSRLALPVILGDLGVHHQDVLRGLGLRRDVPDAVATAIFREGLQLSLWLNRRVLSHRLVPTDGHRPVGRGPEVRGTREALGMWLTGRDSVAGELEFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XLG0</accession>
    <name>A0A1H5XLG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12614">
        <property type="protein sequence ID" value="SEG12614"/>
        <property type="gene ID" value="SAMN04489712_103309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="6871" checksum="4D35C2176E800BCF" modified="2017-01-18" version="1">MFLIIAAVALIALVSSLVYLVEFARASRRDSLFAPADRGGVRRARRVTGMYVRGGQEQLTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XRK1</accession>
    <name>A0A1H5XRK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14341">
        <property type="protein sequence ID" value="SEG14341"/>
        <property type="gene ID" value="SAMN04489712_103376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG14341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="324" mass="34484" checksum="CE4B6AA291FAF41D" modified="2017-01-18" version="1">MLDTHHPGLAERIAAATPPGRDRAVDALRAIAIAGVVLGHWLVTAFVAPPGEHGRLVVASPLQAMPWLAPVSWLFQTLALFFFVGGYVAAKGYKPGTPYGTWVRTRMTRLLRPVPVLLLAWIPASAALVYAGYSGPTLRSVIKLVLSPLWFLIVYAALTALTPLVIALWRRLGWYAAALAFGTVAVVDLVRFGLDGPGALGWVNVLAGWLVPYLLGAAWAHDGVNRRLSVALLAGGVVATSGLILCAGYPASMVGVPGAEVSNLNPPTLAAVTFGIAQVGAALLLRDRLARLMRGPRWWAAVALANLSAMTVFLWHQRIPPGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZP8</accession>
    <name>A0A1H5XZP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16756">
        <property type="protein sequence ID" value="SEG16756"/>
        <property type="gene ID" value="SAMN04489712_103471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG16756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="27256" checksum="EBE6246787A87EA5" modified="2017-01-18" version="1">MRSTRPLYDVVALLARIGVGVVFLAHGWQKIQVGVTATADSFDRMGVPAPTAAAIYATFAELLGGLALIAGLGLPVAGTLLFLDMAGALVFVHAGNGLFLVDQGRARNGFELVLVLGLASLLFAAGAGGRISLDHRLFPRRAPDAPPPPAPASPAPASPAPTAPETTRPKAAPVKAASDTAPDEKPPAAEPPAETAAPKPRSGRPSARSRKKQTGTPNPDPEPEGEPPAAPASRPRLASDIIGDTGQDVFVAGRRKPRGKPGPGTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YHP4</accession>
    <name>A0A1H5YHP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4">3.7.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_10423</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23669">
        <property type="protein sequence ID" value="SEG23669"/>
        <property type="gene ID" value="SAMN04489712_10423"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="PTHR43069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="SSF63433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="FAA_hydrolase_N" evidence="9">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="105"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG23669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="42527" checksum="72EB685C653DF30C" modified="2017-01-18" version="1">MTTIDIPEDSPFGFANLPYGVFSTPGTRPRIGVRVADWVVDLAAALGDDVFAQPTLNPFMAQGHRRWAEVRDRVTELVSGQVPDKAAHPLGSVRMHLPIQVGDYVDFYASEHHAANLGRLFRPGAPPLMPNWKHLPVGYHGRAGTVVVSGTDIVRPCGQLKAPDEDAPRFGASRRLDIEAELGFIVGTGSPLGTPVACDDFAEHVFGAVLVNDWSARDIQSWEYVPLGPFLGKSFATSISAWVVPLQALEAARVPTPPQEPKPLDYLREGEPWGLDIDLTVQWNGQEVSRPPYREMYWSPAQMLAHMTVNGAATRTGDLFASGTVSGPGKHQRGAFIELTWGGKEPVQVNGESRDFLQDGDEVVISATAPASTGGHLSFGEVRGRVLPALTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YS29</accession>
    <name>A0A1H5YS29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26452">
        <property type="protein sequence ID" value="SEG26452"/>
        <property type="gene ID" value="SAMN04489712_104135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="121" mass="12935" checksum="81D8C3FEE870D9D8" modified="2017-01-18" version="1">MEPDQIAAALERAHPGWAVIPGYYTGWFTAIPGPSYPYLDSGMITAIDPTELQRRMALVEASGKNTTGQARPAPVPPAPPPPSNPPKSGREQPPDQPRSHPAHGDGPHPPRGGPPRPSTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZA53</accession>
    <name>A0A1H5ZA53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="10" type="ORF">SAMN04489712_104413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32517">
        <property type="protein sequence ID" value="SEG32517"/>
        <property type="gene ID" value="SAMN04489712_104413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG32517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="15780" checksum="2C995CEF006E5611" modified="2017-01-18" version="1">MLIPRKVKHRKQHHPKRRGMAKGGTKVTFGEFGIQAVEGAYVTNRQIEAARIAMTRHIKRGGKVWINIFPDRPLTKKPAETRMGSGKGSPEWWIANVKPGRVMFEISYPNEAIAREALTRAIHKLPMKCKIVKREVGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZI45</accession>
    <name>A0A1H5ZI45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="6 10">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_104561</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="6 10"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35790">
        <property type="protein sequence ID" value="SEG35790"/>
        <property type="gene ID" value="SAMN04489712_104561"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011269">
        <property type="entry name" value="PUNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01698">
        <property type="entry name" value="PUNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="12">
        <location>
            <begin position="37"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="11">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG35790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="28729" checksum="2D6B12E83297CED4" modified="2017-01-18" version="1">MVPRGAVSVGRVSNDAFDLARAAADELRSRSFDGFDVALVMGSGWVPAADALGEPATELPVTELPGFAPPAVAGHAGRVRAVEVGGRRALVFLGRTHLYEGRGVEPVVHGVRTALAAGVKTVVLTNAAGGLRPERQQVGDPVLISDHLNLTGANPLTGADFMDMTEAYSRRLRALAQEIDPTLAEGVYAALRGPTYETPAEIRMFQALGADLVGMSTVLETIAARRGGAEVLGISLVTNIAAGLSDRPLDHAEVLEAGRASAARMGELLATLLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZT0</accession>
    <name>A0A1H5ZZT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41285">
        <property type="protein sequence ID" value="SEG41285"/>
        <property type="gene ID" value="SAMN04489712_10572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG41285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="457" mass="51299" checksum="173A9695B3CAD499" modified="2017-01-18" version="1">MTAVQRPVVTSARPSRVNQASVADTLRIGATVLVPTVARGVLARRPRIVRLAEAIDADRRAGDLLQRMRSRYGPGPLLLRLPGRRLALVLSPGDVERVLTGSPEPFSPANLEKRSALSQFQPHGVLISDAAKRPDRRRFNEAVLDTSAPVHRYGEAITAKVREEAELLREEIGRTGELDWDTFRVAWWRVIRRVVLGDAARDDSEISDLLTRLRMSANWAYAMPRRRILRHRFQHRLRHYLDLAEPGSLAELVARAPSTSGTEPADQVPQWLFAFEPAGMAAYRALALLATHPDQARKAREEVDGRDLEQPQDLPYLRACVQESVRLWPTTLALLRETTAETAWDGTRMPAGTALLVHTPFLQRDDRTLPYADTFAPWIWLDGTARRSWSDIPFSGGPVECPGRNLVLLTTGLFLAMLIQRHEYRLASGQPLTYAQPLPRTLGPFGLRFQVRPRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1S5</accession>
    <name>A0A1H6A1S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42713">
        <property type="protein sequence ID" value="SEG42713"/>
        <property type="gene ID" value="SAMN04489712_105155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292159" evidence="2">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG42713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="78" mass="8552" checksum="F6ECE142972D28FF" modified="2017-01-18" version="1">MSRRRIIVLTGAAAAIAAVTVVGFAATGQADNDPEPQDPTQSVVHHQVQQDPQEVEEYWTEERMRNAKPVQMPAPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1U0</accession>
    <name>A0A1H6A1U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42699">
        <property type="protein sequence ID" value="SEG42699"/>
        <property type="gene ID" value="SAMN04489712_105154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292206" evidence="1">
        <location>
            <begin position="28"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG42699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="359" mass="37480" checksum="F920C5A31FD6B711" modified="2017-01-18" version="1">MRLSAPRLAVSAAVIGTAAVTASVAFAAAGPGDPAPVTKAGAPTATSDPVVHTFSDISTSAVEQYWTPARMRAAKPVSLPKTVQGTAATPVAEASAQTGDVPAAPVGGTVASGDVSTAAVVGAKQWSNQKSGIARTTGRIYFSRGGSDYVCSGTVVNAANKRTVWTAAHCLHSGGPKGVWHRNVLFVPGYRDGKSPLGRYAGLHGAVTPQWVNSTNANYRFAHDLATFTVGNSGGKRVQARTGAQGIVWGYKKRTYAMRAFGYPVVFLPSNKRTQGHRLYYCSGTTKGIRFHAKAPVSMSLACTMGGGASGGSWLYGMNSKGWGKVAGVNSTHSTQDNRMFSPYQGAAAQKLYNYIKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9F3</accession>
    <name>A0A1H6A9F3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45363">
        <property type="protein sequence ID" value="SEG45363"/>
        <property type="gene ID" value="SAMN04489712_105298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG45363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="6638" checksum="756A80C0DF59D327" modified="2017-01-18" version="1">MGDFPSPRPQWRKSSHSGGGNDACVEVADLGQAVGIRDSKDPDGPALAVSRTALGSFLKGIRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ACH1</accession>
    <name>A0A1H6ACH1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45747">
        <property type="protein sequence ID" value="SEG45747"/>
        <property type="gene ID" value="SAMN04489712_105321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG45747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="662" mass="71093" checksum="CCE5CCD534F421B5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ACT7</accession>
    <name>A0A1H6ACT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46192">
        <property type="protein sequence ID" value="SEG46192"/>
        <property type="gene ID" value="SAMN04489712_105349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025629">
        <property type="entry name" value="DUF4287"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14117">
        <property type="entry name" value="DUF4287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG46192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="75" mass="8762" checksum="3B013799339EA793" modified="2017-01-18" version="1">MSLSHSPETHTKLLARIPAVTGRDLPEWFETIENGPSFLRCTERSHWLADEHGISHGYATALVREHERTRRLRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AGE1</accession>
    <name>A0A1H6AGE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47300">
        <property type="protein sequence ID" value="SEG47300"/>
        <property type="gene ID" value="SAMN04489712_105413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG47300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="11260" checksum="03861509166AA9E0" modified="2017-01-18" version="1">MEHRPESGFPPVYHDMGEGATDAAAQRGIVWPRLFVLTYVPEEAEGIGDDPGEVVLYGLAMPGGGAVTVGPGGMQQGHWVSAGRAADRLGLDLWWRDELPESGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJ75</accession>
    <name>A0A1H6AJ75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRISPR-associated autoregulator, Cst2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48571">
        <property type="protein sequence ID" value="SEG48571"/>
        <property type="gene ID" value="SAMN04489712_105482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013414">
        <property type="entry name" value="Cas7/Cst2/DevR_sub_I-B/Tneap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010154">
        <property type="entry name" value="CRISPR-assoc_Cas7/Cst2/DevR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02585">
        <property type="entry name" value="cas_Cst2_DevR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01875">
        <property type="entry name" value="cas_MJ0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG48571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="37284" checksum="8CA4093C1E945764" modified="2017-01-18" version="1">MTFLVGKIALDVVAGAPNNGLGQDNVAKVKQMRVGRDVHPYVSAQAFRRWLRDSLPADEPRSTVVRSGSGKKQQAYTAGRPDRYLDDDLFGYMVAVKGADTCQRDTVVANGTLVAVAPRRPEKDWGTMSRDFAAGENPVIHEHEFYTAELAGDLLVDLPRVGVFETDGTGLKVALTATAATEAEQGGAEPVELCGTRALRLPIDERRRRVAVLLRTLAGLRGGAKQSLHYGDRTPALVLLAPMKGGVNPFTRVLGVENDKVVFSTDVLREELDAWADELDGPVLLGWAPGFLGRQRARAETELTDLITDERLVLGHPRKVLNELAVDIQAGRRDGWFEDPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3H8</accession>
    <name>A0A1H6B3H8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SAMN04489712_106227</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55378">
        <property type="protein sequence ID" value="SEG55378"/>
        <property type="gene ID" value="SAMN04489712_106227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="229"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="523"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SEG55378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="844" mass="93918" checksum="803C8DA3B2D53130" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BFS5</accession>
    <name>A0A1H6BFS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59510">
        <property type="protein sequence ID" value="SEG59510"/>
        <property type="gene ID" value="SAMN04489712_10773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="223" mass="22791" checksum="AEBC4964BF32F0A5" modified="2017-01-18" version="1">MCGGRWGSQHGGMWKPISVLAGTAMVVTMSGCSVLSEADEGTPGDTKASTAAGSQGPRTFVLGQTVAGLSRDPESDGEGRLVVSANRRVFEDLPEYQTSGAAGAIYGTAPPPPRTVALGDDQVVVAGANGKFADPKAAIAVFQKSARGTLTDPADAPVTEVDPGPLGGSASCIELPTLSEDQKFTACYWADATTAGMAGMKGKSPQEVAGFMRRARQEVTQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BH40</accession>
    <name>A0A1H6BH40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60033">
        <property type="protein sequence ID" value="SEG60033"/>
        <property type="gene ID" value="SAMN04489712_107105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="364" mass="40061" checksum="F367D0366155C812" modified="2017-01-18" version="1" fragment="single">GNLLFLSTDSSRSDDSCQSTSKPVTDPTAWEGIKIFDISDVRNPRYVKAVETECGSHTHTLMPGKRGETYVYVSSYLPTPASSGVGPDCQEPHDKISIIKVPLKNPTAAAVVAEPVLFPDGGNPGDGRPYPEGTRATSGCHDLTTYPDEDLMAGACMGDGVLFDVSKPEAPKIIDIVRDDENFAFWHSATFNSKAKKVVFTDELGGGGLATCTAAFRPEQGANAIYDIVGQGDKRKLRFRSYYKIPRINADTENCVAHNGSLIPVKGRDIMVQAWYQGGISVWDFTNSRKPKELGFFERGPLSTTRSITGGAWSTYYYNGYIYSNDIQKGFDVLKINDKDLDKAKKVRLDELNVQTQPDYFDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BM44</accession>
    <name>A0A1H6BM44_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="3" type="ORF">SAMN04489712_107241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61750">
        <property type="protein sequence ID" value="SEG61750"/>
        <property type="gene ID" value="SAMN04489712_107241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG61750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="157" mass="16958" checksum="CA30F35FF267EEB8" modified="2017-01-18" version="1">MVDAARARKLADRIQQIVAEMLERRIKDPRLGFVTVTDAKVTGDLRDATVYYTVYGSEGERADTAAALESAKGIIRSEVGRRTGIRHTPTLTFEFDAVMDNARQIDDLLARARAHDEQVAKAAEGASPAGEANPYRVGEEDAESDVDADGGKGHSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPF8</accession>
    <name>A0A1H6BPF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylmalonate-semialdehyde dehydrogenase [acylating]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_107308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62609">
        <property type="protein sequence ID" value="SEG62609"/>
        <property type="gene ID" value="SAMN04489712_107308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="25"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG62609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="503" mass="53405" checksum="7162806AE5163407" modified="2017-01-18" version="1">MNSTEGKHVRHWINGKPYDGPAARRGDIHDPATGRPSGTVDFASQTEVDAAVAAAKAAFPAWRDASLAKRASVLFRFRELLTAHRDELAELISSEHGKVVSDAAGEVARGLEVVEFACGIPHLLKGGFSENVSTRVDAYSILQPLGVVAGVTPFNFPAMVPMWMFPVAIACGNTFVLKPSEKDPSAAVRLAELWAEAGLPDGVFNVVHGDKVAVDGLLEHPDVKAVSFVGSTPIARYIYESAARHGKRVQALGGAKNHMVVLPDADLDLAADAAVSAGFGSAGERCMAISVLVAVDPVGDALLDKIAERVARLRVGPGHDPASDMGPLVTRQHRDKVASYIDSGLAQGATVAVDGREVRVDGEYADGYWLGPTVLDHVTPEMDAYTDEIFGPVLSVVRVSSYDEAMKLISDNPYGNGTAIFTNDGGAARRFQNEVEVGMVGINVPIPVPMAYYSFGGWKASLFGDSHAHGMEGVHFYTRTKAVTARWLDPSHGGVNLGFPTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXD6</accession>
    <name>A0A1H6BXD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster assembly ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65302">
        <property type="protein sequence ID" value="SEG65302"/>
        <property type="gene ID" value="SAMN04489712_10893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG65302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="27337" checksum="65F9C8287DB00C21" modified="2017-01-18" version="1">MATLEIRDLRVSVGDGSDGAKEILRGVDLTVRSGETHAIMGPNGSGKSTLAYAIAGHPKYEITAGTVTLDGEDVLAMSVDERARAGLFLAMQYPVEVPGVSVSNFLRSAVTAVRGEAPKLRVFTKEMKAAMDALSIDPDFAQRSLNEGFSGGEKKRHEILQLEMLKPKIAVLDETDSGLDVDALKVVSEGINRFGAAGDTGVLLITHYTRILRYVRPEFVHVFAGGRIVEEGGPELAEVLENEGYEKYVKAGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYF6</accession>
    <name>A0A1H6BYF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferases group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65739">
        <property type="protein sequence ID" value="SEG65739"/>
        <property type="gene ID" value="SAMN04489712_108130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="319" mass="35784" checksum="3CFF37D597409FD2" modified="2017-01-18" version="1">MRILIWHVHGSWTTAFVQGPHTYLVPVTPDRGPDGLGRARTWDWPPSTVEVPLDRLHEEEVDVVILQRPHEEELVRRHLGRRPGRDVPAVYLEHDAPWGDVPLTRHPMADRPDLLLVHVTHFNRLFWDCGTTPTRVVEHGIVDPGPRWTGEIAHAAVVVNEPLRRGRYVGTDLLPFLTVGTPLDVFGMQVGELPGRLDIPAARAFEDLPQHRMHDELARRRAYLHPVRWTSLGLSLLEAMHLSMPVVALATTEVVEAVPAGAGIISTDPDVLATALRRLMNDPAEAAELGKAGREAALERYGLGRFLDDWERVLTEATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2B6</accession>
    <name>A0A1H6C2B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67023">
        <property type="protein sequence ID" value="SEG67023"/>
        <property type="gene ID" value="SAMN04489712_108247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045998">
        <property type="entry name" value="DUF5954"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19379">
        <property type="entry name" value="DUF5954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG67023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="34813" checksum="7CDCCB4B083F7E91" modified="2017-01-18" version="1">MAFSLMPGYDHINVVADLDPVAAVRDREIGERMRAYPRICPAGSPDFGYAVQTGSRWRIGCAGACDPAGARYDLARHLRESAAGHTGDAGVARAMLAAAGRLDPEEGAQLPKDEWEIGDRRYRVVRIEQFTLLGDRVMEPPRPTDTDPPDGSGLLRDHPIDPQAPVGPWEAQLRLNLIGYMPVLGTDSETARAEARHAVRAHPGVILLPPTFTVVEIEEDSWKPLTGGAGPAQARAHLAGHFTEVLPRLRQFHGDPATPGELAEWARAAEQIEATAGHEFTALGRRFRTVRVSRMLRVGRDGPEGPRPSDQERYGLPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7I4</accession>
    <name>A0A1H6C7I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68924">
        <property type="protein sequence ID" value="SEG68924"/>
        <property type="gene ID" value="SAMN04489712_10932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG68924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="23947" checksum="0FE1EBC2E769E7AB" modified="2017-01-18" version="1">MTTSSTDRPTHPAHAGPQPSATGGRAWAVSGVVGALVAFVTLFFLSVELTNVDESLLGDNARLVQAIQGDKTIVWIVQAGTSLAALLVLVFGAGLRRRLAQDEPDGSLLPLLAFAGMLLVAAMLLVGGGISTELYHGLRRYADADPDTIAANLAIYNTMAWLWAGAGLSAGAVAVAGFRRRVVGRGLAVFSAAMAALIALTQLFPVQYIALVPGVLWVVVAGAAFALGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7V8</accession>
    <name>A0A1H6C7V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69059">
        <property type="protein sequence ID" value="SEG69059"/>
        <property type="gene ID" value="SAMN04489712_10945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="202" mass="22396" checksum="2CD1E344B3DE3A0E" modified="2017-01-18" version="1">MPSAGLPAEIEVPTTIWPSYGDGMDVVFTRTGERRYGLTITAPGAPPRGMDPAPGYDDHIPHDLVHYIVEAELKLSAGLYGRAAKGGGSFLLLGDVPGRRERSRKQRRLKKREAHLREKDHAGSADMARSEHLAAVCDLAWRRRRLSRGERPPWVTEPEISEEDRPAVERVLARLDEVAPLWNALDVGGSLAFTWPSAHPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CA13</accession>
    <name>A0A1H6CA13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69597">
        <property type="protein sequence ID" value="SEG69597"/>
        <property type="gene ID" value="SAMN04489712_109100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294609" evidence="1">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="94" mass="9879" checksum="9921AD44A4ED8ADB" modified="2017-01-18" version="1">MLKRLAAAGILSVAAGGVLMSATPAMAGGDHDKDIYSNHHNVLANKCDIDQGNEHNGLLGLDIIEDVALLAVNSANDIYKAECEQSNAILNKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CA36</accession>
    <name>A0A1H6CA36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein E (SpoIIE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69859">
        <property type="protein sequence ID" value="SEG69859"/>
        <property type="gene ID" value="SAMN04489712_109121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="189"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="418" mass="45419" checksum="C2D80B66BF557564" modified="2017-01-18" version="1">MPGVEKVLRMLGELLRAGHLTGIEQLPGLVTKQAAVADLEQVHIYVADLRQQVLRELTGQGLDAGEGGQELPIENTLAGRAFRDVRTIAAPGAGAGRQRYWVPILEGAERLGVLRADAADGDADADADADGDGGDDVRQALEHLASMIGLQLISKNLSSDSYARLRRTEEMNVAAEMQWALVPPRSFANGQVTISAVLEPAYRVGGDAFDYAMAGDTLHLAVFDAMGHNIAAGLTANLSIATCRNQRRQGVDLASISDRIERVLIEQFGPGRYITGVLADLDLVTGRLSWVNRGHQPPVLIRGGRWVTTLNCLPAHPMGTDLDLPVTVCREDLQPGDRILLYTDGVTEARDAYGREFGLSRFTEFIIRHQADGLSVPETLRRLMGAVLAYHGGQLQDDATVVFCEWHNPIPDRENRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CB04</accession>
    <name>A0A1H6CB04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine dioxygenase, alpha-ketoglutarate-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69967">
        <property type="protein sequence ID" value="SEG69967"/>
        <property type="gene ID" value="SAMN04489712_109130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG69967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="239" mass="26131" checksum="F44370C2F662F4FB" modified="2017-01-18" version="1">MKIFSTEGRGISEDDVPGALAERGVLYFRNGDLGSVRSHVFDWGRPYDHPHQSAPGITLIRARHTRPPAGLSGFTRDRLALHTDRATCAEPPAVVATLVLAAPRAGGQALLADSARVLTAWSRRRRLSTARRSAFLETRKGRTLRPLIDSAPTGGVRIRFRDDGIARPAAMGPAGEEFIGELKRLCSRPVVLDLGPGEGYLIDNYRYLHGRRSFVGERTVVRFLATPGPDHTIPFGFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CC48</accession>
    <name>A0A1H6CC48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70551">
        <property type="protein sequence ID" value="SEG70551"/>
        <property type="gene ID" value="SAMN04489712_109179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="26988" checksum="38EB32B8E51A6C4D" modified="2017-01-18" version="1">MSAEALLRCEVAEGVGTVTIDRPDKRNAMSAAMWRALPALLERLATDPAVRAVVLTGAGGHFCAGADIGELADINPGDLPVAAEEALVAFPKPTLAVIRGFAVGGGCQLAAACDLRFAAEDARFGITPAKLGIVYPGASTARLVRLVGPAAAKYLLFSGELVDAAHALRIGLLDEVLPAADLDGRVAEFTRVLTARSQLTQQGAKEIVNAAAAGALTPDLVDAWERESRKGVDSTEGVAAFLERRAPRFTWTGPAAHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CET0</accession>
    <name>A0A1H6CET0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase/secretion neighborhood CpaE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71519">
        <property type="protein sequence ID" value="SEG71519"/>
        <property type="gene ID" value="SAMN04489712_109279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022521">
        <property type="entry name" value="CHP03815_CpaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03815">
        <property type="entry name" value="CpaE_hom_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG71519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="359" mass="36828" checksum="500222E3013277F3" modified="2017-01-18" version="1">MAIDALIATGDPRIADDLLRLAAAANADAALASTAEQARTQWRRPPLVLVGADMADGLAADGVARRTGVVLVTTEADAPDGFRAAVEVGAQDLATLPADEPWLVDALAAAAEPCDGRATTVCVVGGRGGAGASVLAAMLGLAGARGGLRTLLVDGDPMGGGVDLLLGQENAPGCRWPDLAGRRGRLGAGLLRESLPAVDGLVMLSWHRGDADPLTAETMHTVLDAASRGFDLIIVDLSREPGAAGRAALRVADRTLMIVPAELRATAAADRVAVSLQRDTDDIRLIVRGPAPGGLPAEAMAEALGLPLAGTVQEDRRLPSALERGDLVRLSRRGSLPDLCDRLIGDLRPRPAALEAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKD4</accession>
    <name>A0A1H6CKD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_110105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73392">
        <property type="protein sequence ID" value="SEG73392"/>
        <property type="gene ID" value="SAMN04489712_110105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG73392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="483" mass="49415" checksum="B58DCE3DF6BAFAA8" modified="2017-01-18" version="1">MSTTDGRMDGRAWGVLLVLCGAIFLEGVDVAMLNVALPSIRADLDLSTGTLSGVVSAYVLGYGGFLLLGGRAADLLGRRRMFLLWLAVFCVFSGLGGLATESWMLLVARFVTGVAAAFMAPAGLALITGNFPEGPQRTKALGVYAGTASGGFSLGLVAGGLLASLGWRWVFFAPVIMSAVILAVAIPLVKDTESTSERPAGGFDLPGALTITGAMLLLAYGVVRLEHPAQGRAVTAGVLAAGLALLAAFAAIERRSSDPLVRLGVLRSGVLVRTNAAALLFLGAFGGFQFLVTLYLQELRGWSTLETGLAMLVIAIDIVLAPTLTPRLVNRFGNARVLFGGLVLAAVAYALFLPVGLEWTYAAMLPSLVLLGLAFTLAYGPLTMAAVEGVAEREHGLAVGLLYTATQFGIALGLSAVTAVNVAALGTGNSPEAGLDAIRTALLVPVAAAALGAVIVAFGLGSRPAAGTARSDTEQPTSAELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKL4</accession>
    <name>A0A1H6CKL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73551">
        <property type="protein sequence ID" value="SEG73551"/>
        <property type="gene ID" value="SAMN04489712_110124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG73551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="30424" checksum="668C0E2F7E02F927" modified="2017-01-18" version="1">MDTMSSYAHVLAQAQSETRELVQVERHQGYAVLRLADPGKLNVLSAAMSLQIRTALGELTADPAVRAIILTGADPGFCTGGDLRLMREVTRALADPADEHGATTPWRFIRREFGAIVRMIAGRDTAVVAAVNGPAAGVGLAMAFACDMVIASDRAVLVPAFGKLGLLPEVGTSWFITRRLGYQRAFEYYVSGEHIPAQRALELGVVNEVVPHEELLDRARSWCERMVALPEHALAMTKPLLRQAADMSWEQALTMEEYAEPSCFTTKPFARAVEGMLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLZ5</accession>
    <name>A0A1H6CLZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-ethylmaleimide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74069">
        <property type="protein sequence ID" value="SEG74069"/>
        <property type="gene ID" value="SAMN04489712_110186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="3"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="358" mass="38408" checksum="BA480AEF5A114296" modified="2017-01-18" version="1">MKELFEPVTVGKATLPSRLVMAPMTRSRAAEGGLVTELTAEYYAQRAEAGLIVTEGTQPNVVGQGYTDTPGLHSAEQVAAWRKVTDAVHARDGRIFAQLMHSGRIGHPVLYPDGALPVAPSPIPSGGQLFTPEGMLDHPTPREMTVDDIAETVRDFAAAARNAMDAGFDGVELHGANGYLIHQFLADGSNRRTDAYGGSIAGRIRFPVEVVAAVSDAIGPERVGFRMSPGNTFNGITESDTEELYTELTRALAPYGLAYVHVMELGNREITRRIRAEWPGSLILNPHPAQAESPSTPEHGVEALREGVADAVAFAQLWLANPDLPARIKAGGPYNSPDPATFYGGDHRGYTDYPLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT34</accession>
    <name>A0A1H6CT34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_111130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76160">
        <property type="protein sequence ID" value="SEG76160"/>
        <property type="gene ID" value="SAMN04489712_111130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG76160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="36305" checksum="43478E1097970776" modified="2017-01-18" version="1">MTSTTETGPAAPEAPRHTRALRGGLLIAALAVALVVAVVVAASLGQVSIPPQEVLGSVMHRLGLDLGPQPTGPQAENALWVVRFPRVALAAVTGASLACAGAVMQGVFGNPLAEPGVIGVSSGAAVGAAAVIVFGLNALGNWTVVLAAFAAGLLTTLLVYAVARSGGRTEVVTLLLTGIAVTAVASALLGLLMFASGNDALRAITSWQLGSLASATWPAVAAVAPCTAAGLAVSCACARRLDVLALGERAARQLGVDVERLRLTGVAVIALTTSAAVAFSGIISFVGLVVPHLVRMAVGPGHRVLIPASALGGAVLVVAADLVARTSIPYQELPLGVLTALVGGPFFFWLLRRTRNRAGGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUW0</accession>
    <name>A0A1H6CUW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_111202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76752">
        <property type="protein sequence ID" value="SEG76752"/>
        <property type="gene ID" value="SAMN04489712_111202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG76752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="213" mass="22488" checksum="3C6FFDC44C4F3622" modified="2017-01-18" version="1">MPSLSTLVLYVIAATLVLVAPGPAVLYVVSQGIRHGSRAAVTAVLGVHAGTLVQVAAAVLGLSWLLLNSSLAFMVVKYVGAAYLIYLGVKALLSRTKAMEDPAAEAKTSRRLLGEGFLVNLLNPKLALFFLAFLPQFVDPSRGAPALQITVFGLIFVLLGLCTDGAYALLAGVIGPWLRGRSRVLRGERYVVGTTFIGLGLFAALTPSTQRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYR0</accession>
    <name>A0A1H6CYR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG77928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77928">
        <property type="protein sequence ID" value="SEG77928"/>
        <property type="gene ID" value="SAMN04489712_1122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295363" evidence="2">
        <location>
            <begin position="25"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG77928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="23377" checksum="EDB817BE414148E9" modified="2017-01-18" version="1">MRMSSLTRSIPLAGALVVPLVVMAAPASHATEGARGSAYGVVADGLVTLPATPSVQSTSTRPIRESVVDLPKNPLVNASALVTSARAGYGRASVADLKLTKALLNAELVTARCQARKGSAHLGKAFLQGRRLAVTPKPNSALQVPIEGVGTASVVLNSQRRTPAGDLTVTAVEVNLPPVAGKPQRVGIASVTCGAKATPAKPKTPPQQQKPQIPAPAPKPVPRDLPVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0Z2</accession>
    <name>A0A1H6D0Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79021">
        <property type="protein sequence ID" value="SEG79021"/>
        <property type="gene ID" value="SAMN04489712_112155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="32985" checksum="4B21D8EA4B144081" modified="2017-01-18" version="1">MAAKKNTVTAPAAPAADIATTTPDTATAPASTARPDGPAGVVWDAVTANPGATVPVIANAAGVARAVAKAELIALATSGRVVCTPGGRGDNGRALPDTWAPAQDTTDITTVPVPGTAPEGPAAGAAEATVPQAPAVTAEAIAEAMRIMQAEADRRAAAEADLAKAMAEEEARRAKVLADLAKARTAEDTRRALADLLTAVTTTYAAVVAGDEAATTAGLERIHTEANNVRKASKAGPVRTGAKGTGTVRTDRAAPRPLRPEVVAHLNAHPGKEFTPGEIAKVLGRSSGAVANALETLAKNGEAVLTSERPARYTAPTATATGTAAGDGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D100</accession>
    <name>A0A1H6D100_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79069">
        <property type="protein sequence ID" value="SEG79069"/>
        <property type="gene ID" value="SAMN04489712_112163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="21035" checksum="83972F15691A9A19" modified="2017-01-18" version="1">MSQVDSQSDDETLLTTLKRAASALKEAGVEFALAGGFAAYARGAAISTHDVDFIVREQDVDAAVNALTAVGMRYQDCPEDWLAKVYDDDRLIDLIFRPSARPVDGGLLARAEELPVAAVNMPVLPADDLMIMRLLAFTETACDFSDFLHVCRALREQVDWPKVAKETAHSPYAYAFLTLLHRLDVIEGDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3Z0</accession>
    <name>A0A1H6D3Z0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted metal-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80079">
        <property type="protein sequence ID" value="SEG80079"/>
        <property type="gene ID" value="SAMN04489712_1139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201_N" evidence="2">
        <location>
            <begin position="145"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="1">
        <location>
            <begin position="263"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="42441" checksum="0C66C177CCAB3FE7" modified="2017-01-18" version="1">MTGLDRTKLLAARYRAATDRPYLASALYSLSVVPTDRVPTMAVDRHWRCYVSPAFVDACQVPELAGVWIHEVAHLLRDHHGRADRLPAADRRDRLRVNIAQDCEINDDLVSDRLALPPGRVVPGDFGLPNGEMFEAYLPGIPPSPPEHDCGSGAHGEPSPWEIGEGAARVGPVEAEALRRHTAEAMRAHQRARGNLPAGWQRWADQVLEPVVDWRQALRGAVREAVAWAGGAIDYTYHRPSRRTAAMRGVVLPSLRRPLPRVGVVIDTSGSMGEGDLAAALAEVTGVLREVGVRGNRVTVLACDADVHAVSRVASAGQVGQIELGGGGGTDMRVAIAAALAMPDRPQVLIVLTDGFTPWPAETPSCRLIAALIGADPPDPPGWLETVRIPAHPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4Q5</accession>
    <name>A0A1H6D4Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MAM domain-containing protein, meprin/A5/mu</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80034">
        <property type="protein sequence ID" value="SEG80034"/>
        <property type="gene ID" value="SAMN04489712_1131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="172" mass="17659" checksum="8F7BF338E6650468" modified="2017-01-18" version="1" fragment="single">DDFETNKGWTVNPNGSDTATAGQFQRGIPQATNSSGVNLQLTAAGGSYDLVTGASAGTAAGDYDVDGGTTSIQSPAITLPSGTLTLSFSWYLAHLNNATSADYLRIRIVGTTTTTALNQTASATNRAGSWQNATVNISAHAGQTIRILIDTADTSTASLIESAIDNITITQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5L9</accession>
    <name>A0A1H6D5L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80551">
        <property type="protein sequence ID" value="SEG80551"/>
        <property type="gene ID" value="SAMN04489712_113101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="295" mass="32760" checksum="D0A0964600DE1906" modified="2017-01-18" version="1">MTIAQPHRRSAGRQQSGPTALRIVLGGRLRRLREEAGLSRAEAGALIRGSESKISWLELGKVGFKPRDVGDLLDAYRVTGDLRETLLSLAAQANRPGWWHQYSDVLPQWFETYLGLEQDATRIREYEVQFVPGLLQTEDYARAVARLGHPAAGADEIERRVELRMRRQRLLTGPASPRLWAVVDEAALSRPVGGRAVMREQLRHLIDMCAMPGVILQVVPFESGGHAAAGGAFSILRFAESELPDVVYLEQLTSALYVDKPADVERYLAVMERLCLDAEPPSRTADVIAGILDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8B2</accession>
    <name>A0A1H6D8B2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_11484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81560">
        <property type="protein sequence ID" value="SEG81560"/>
        <property type="gene ID" value="SAMN04489712_11484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG81560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="31281" checksum="2E92342AE6732167" modified="2017-01-18" version="1">MTATTATEVVRVQVPERSVRHDLRAVKIVFHRELLRFWSDRMRMISGLIQPALWLLVMGTGLSSLMATGGGEVDLKTFIYPGVCAMTVMFTAMFSAASIVWDREFGFLREMLVAPVSRGAIVVGKCLGGAFVATAQGVVIVAMAGLAGVPYDPLLMLTLVGELFLGAFALTAFGVLLAARITNMQSFFAIMQMAMMPMLFLSGALYPLSGLPGWLAVLTKLNPLTYAVEPMRQAVFSRLDLSPELERAFNSGVTWNGWPVPVWLQLVMVAVMGLGLLGVAVVQFRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DA57</accession>
    <name>A0A1H6DA57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_114123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81703">
        <property type="protein sequence ID" value="SEG81703"/>
        <property type="gene ID" value="SAMN04489712_114123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="142"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="34795" checksum="2A2F81567E697698" modified="2017-01-18" version="1">MSHPTTRVLAMLELLQAHPRMGGAELAARLGVDQRTVRRYAARLEELGVPVVADRGRYGGYRLMPGYRLPPLMLTDDEATAVVLGLLAGRRTGLPGEATESALAKVQRVLPAALRDRVQALAETLAFTTAARPGTAPATDAVLTLAAAARRRRRVRLGYRSWKGETSERDLDPYGLVFHSGRWYVTGHDHLSGQIRTFRVDRVRSVGQLPHTYQVPDGVDPVEHVTRSLAAVPYAHEVEVLLETGLQEARRRIPSTTATLTPADGGVLLTTRAQRLDGMALMLAGLGWPFVVRRPPELREAVRHLADTLRAQAARAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBA8</accession>
    <name>A0A1H6DBA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YjbI, contains pentapeptide repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_114140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81776">
        <property type="protein sequence ID" value="SEG81776"/>
        <property type="gene ID" value="SAMN04489712_114140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="398" mass="42416" checksum="2FA8F98B05A58DC9" modified="2017-01-18" version="1">MSASHVSEPSPSSGAPAPPADRADDASPPAPSAVPQIPEPTPEELRNIPADRRLELLELQRQRLDAERDRRRHSKHQWFNSIGILIGVLAAVAGLVATVLTWRAGQDELHIAKEGQVTDRYTKAVEQLGSDKREVRTAAVYALERIARDSARDRPTIIDVLAACTREHDPAPAIKDDALPPEPDTDVAAALTVLGRLPRPAPAPSSRRILIPSSIHTLDLHSIRVPHSQLSRANLNDADLTGANLSEANLREATLIDADLNDVDLTGADLNDADLTLVDLVDADLSGATLSDANLRRAILADADLRDVILSDASLTGAFLSRADLNGAILSLADLTGADLTGADLTDAYLLDANLTGADLTDTDLTGANLTGADLRKIKGKSADEVRRVARTDATTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE35</accession>
    <name>A0A1H6DE35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83484">
        <property type="protein sequence ID" value="SEG83484"/>
        <property type="gene ID" value="SAMN04489712_1163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="22959" checksum="E77779749BC34653" modified="2017-01-18" version="1">MQPRLLTLEMNTPVPDGGAGFRAICQSWLEEGLRTVGGDFLEQLESGPPLPRLGTWRHEGEVSDGPPGSTWALLSVTRLSARGSRRSMVRVWSPQGVEWLYRSLEKVPLEAQIDVSVLNRYGTPGDRGVRVTVERPFEVPDWLVLTIRRYLGLGAGPGIVRRFGDRMYEMLESQASRTDATFGYIADDAESIMGLTPLEDSLWLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE81</accession>
    <name>A0A1H6DE81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82866">
        <property type="protein sequence ID" value="SEG82866"/>
        <property type="gene ID" value="SAMN04489712_11598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="29697" checksum="F2C1061267C59BB8" modified="2017-01-18" version="1">MDRVDWENLPDALYEAVHQQLGPLAKVQAIAEGRRTALVAAAWTRSGDRLFLKGAPVASRAGEQLAREQAVAPYVAAIAPELIAAVEAAGWRLLVFEYTDGVRGDYSPASPDIPKVLDILAELDRTEVPSEVPLICFEARWSSYAPAGRELPRLAGSAVLHTDLNPTNMRVGDTVCLVDWAAASRGARFVNPADFVVCLIACGHTPHDAEAIAAALPAWQDADSADIDYYARTLSTAWLHAFWDRPHPWAKAIVTAAQRWVMHRRDLCLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE91</accession>
    <name>A0A1H6DE91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_115100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82876">
        <property type="protein sequence ID" value="SEG82876"/>
        <property type="gene ID" value="SAMN04489712_115100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="195" mass="21909" checksum="4735569E0D09C314" modified="2017-01-18" version="1">MTGEHGFEPLDSWWLHVPRLSNAFQLQCFADDAVRRLWWGNQVVGAIERHPVAGERWFSLGRDGLRLIPEPDVEPNGLYADPEAALLHARDAWRARDATVYDALGLDYWVEPRFRRGRGVESLWLGRTHLGLIQPAPGGTWSAFPTEDAPAASEGAITDAAEVTRDGTYPTRHAALRAVQHTWRAHLHRILGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF56</accession>
    <name>A0A1H6DF56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_115170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83206">
        <property type="protein sequence ID" value="SEG83206"/>
        <property type="gene ID" value="SAMN04489712_115170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010581">
        <property type="entry name" value="DUF1152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06626">
        <property type="entry name" value="DUF1152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="38391" checksum="BE840F1117AFA7BE" modified="2017-01-18" version="1">MTRLYVAAGGGGDALAAAIIHAATSSEPAYIATFAWDRLLIDPLPGPRSARDFTGLHRLGEHVTAITPDTRPIPPAGSTLPRLAAEINATLVLLDPTNGATGLRAQLRDLAALLAVPRAEVIDVGGDALAHGDEPGLRSPLADALALSACHDLGIPVGVLIAGPGLDGEIPEPDVLARVGNTMAARLHQADADRYAHVFDWHPSEATALLAAAARGARGTAEVRDSGLPVTLTDHSPNAYRLTLAQALSINTPARAIQHTTSLDQAEEITRTLCGFSEIDYERAKATRNRPATHTTITEDLDRKARAYERDAAARGIDFLTFRRLAEVLGLSATVTGHLRTHLIATRPAHYLPPIWATRPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIK8</accession>
    <name>A0A1H6DIK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_117121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85044">
        <property type="protein sequence ID" value="SEG85044"/>
        <property type="gene ID" value="SAMN04489712_117121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="260"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG85044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="384" mass="39486" checksum="54C5FACE141AE3DE" modified="2017-01-18" version="1">MPEAVITAALRTPIGTAFKGTLRDTTAYDLADHVVRAAARGLDPTLIDDVVLGEGLYGGGVVARHAAITAGLTSVAGLSNNRHCAAGQAAVQSAAASIRAGMDELVIAGGVNSASTSPKSRFRVGEDWLDPWNPPTHPDRPDAPNLDMSITVGWNAAVRAGVTREEMDAWALRSHRNAVRAIDEGRFTEEIVPIETPHGLFSVDEHPRRDTSMEKLASLKPLHPEIEGFSITAGNASGANDAAAALVVASDRLAADRGLPVLATVRSWASVGVDPAETGLAPVKAIPKALARAGLSPSDVDLFEINEAFAAMCVATIGLLGLDPERVNVNGSGCGLGHPVAATGARMLVTLVHQLRRQGGGIGVAAMCAGGGMGSATVIEVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIM0</accession>
    <name>A0A1H6DIM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84683">
        <property type="protein sequence ID" value="SEG84683"/>
        <property type="gene ID" value="SAMN04489712_11749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="134" mass="14304" checksum="CBC82AB8A23F6690" modified="2017-01-18" version="1">MHTPDTLEKLHTLRTAVARHDELATRHALACDEPDAPAALTRQQALELLALGEVIARKAAYGRQLVVRSARAAGASWSQIGAALGSSKQAAWEAHHRWIDEQARRDLGDAHLGLTPEEEAAARALAGPPDPAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKE6</accession>
    <name>A0A1H6DKE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Raffinose/stachyose/melibiose transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85589">
        <property type="protein sequence ID" value="SEG85589"/>
        <property type="gene ID" value="SAMN04489712_11840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="100"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG85589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="325" mass="34648" checksum="E86EEE07F32B291B" modified="2017-01-18" version="1">MVRGPVGEVTRPTGPGRLGAEADAAGPAVAASGRRRRVRRAYAWFLVPALALYSFVVLLPSVQGATFAFTDWDGLNPTRHFIGLANFRQMLEDPAARGALRQTLVIAAAVTVVQNAVGLLLALGVHSRIKSRNVLRVLLFAPAVMTPVVTAALWKYMLAPEGALNGLIAAVGPDSWQQNWLGDPTLALCSVAGVVVWQFAGYSMVIFLAGLQGIPQEVYEAAAVDGASGWQRFRHVVLPLLAPATTINLMLSVIGGLKLFDQVWVMTQGGPGTATETLSTLIYKNAFQLDEYAYSVALAIVLTVFVAVISGGQYRLLHRGGEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPB8</accession>
    <name>A0A1H6DPB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87207">
        <property type="protein sequence ID" value="SEG87207"/>
        <property type="gene ID" value="SAMN04489712_12087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="41869" checksum="60742DCBAA20A8CF" modified="2017-01-18" version="1">MEHDGLLDAHDTAGDPGELLRLARELEDAGRRRLAATAYDRAHALDPSDAEVAEARWALLDAMSVEEHGIRFRYIPAGTFLMGSADGEPDERPVHPVRLDDYWMSEAPISWAAYCDLMGWQPPPHGFPPDTVEQMQGFHLHEENKIRLQYCEDDTTRAVDWHAHAAPHTWRRGDGEEIDSRDLFGTPPREDANRPWRYDTKPMVSVSWQDAEELCERLTTGKVQYRLPTEAEWERAARGGLIGRRYPWGDEPPTPQRCDFDRFDELSILPSRRLPPNGYGLYAMAGSVWEWTSDWYDAEYYKESPATAPPGPAKGEERVLRGGSWTDCAEAVTVSFRMSRGADSWRSGEWGDHLTPNIGFRLCRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPK2</accession>
    <name>A0A1H6DPK2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87141">
        <property type="protein sequence ID" value="SEG87141"/>
        <property type="gene ID" value="SAMN04489712_12075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="292"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="502"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG87141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="743" mass="80464" checksum="E534E032B681E625" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DR76</accession>
    <name>A0A1H6DR76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87907">
        <property type="protein sequence ID" value="SEG87907"/>
        <property type="gene ID" value="SAMN04489712_12132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="629"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG87907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="874" mass="94279" checksum="E08CB15751AFFF47" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSB9</accession>
    <name>A0A1H6DSB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhnB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_120146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87505">
        <property type="protein sequence ID" value="SEG87505"/>
        <property type="gene ID" value="SAMN04489712_120146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="15367" checksum="52917E14F1D4274C" modified="2017-01-18" version="1">MPGDRCVPTVARMEIPEHYQYAVIPHVMVDGAAEAIEFYAKAFGATELFRLDGDEGRIVHAEISVQGSTLMLGDADTPFSPPGEGGASVVLHVYVPDVDTLTTQAVAAGAELLSPPADMPYGARQSMLRDPFGHVWIFLTPIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVC4</accession>
    <name>A0A1H6DVC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88666">
        <property type="protein sequence ID" value="SEG88666"/>
        <property type="gene ID" value="SAMN04489712_12255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="232"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG88666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="376" mass="39033" checksum="E8B57BF382F92225" modified="2017-01-18" version="1">MTTTVGIEKDLREALGRLLAERCDHEHVAALADGPQEWDRDLWAELAAMGLPGLVVPPEHGGEGMGFALAAAAQEELGRRLAPVPAMSTTAVQAALLASGDSAEAARWLPRLTSGEVTAAVAAGRTVDGWAMADDVRATRAPGGWRLSGRVPVVADAAAAGLLLVAAGADGDPALFLVDATVKGVRIDRLDALDPTRPLAGVRMDGVPAGRLAGHEEFTEVFQAAERAALVLLAADAVGVAAQAMDMAVEYAGTRRQFGRAIGSFQAISHRCADMLVAVESSRALVAAAAASLDDPSEDTAVAVDLAAAHALETAVRVTGGCVQVHGGMGFTWEHPAHRYLRRAKAAESLVALPDRLRDRAAAALVARLDHDNEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWF5</accession>
    <name>A0A1H6DWF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aromatic acid exporter family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89056">
        <property type="protein sequence ID" value="SEG89056"/>
        <property type="gene ID" value="SAMN04489712_12311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="451" mass="49517" checksum="3875440C6B235CE7" modified="2017-01-18" version="1">MPSRQAVRERVRTVTSPRRLWTVGHSDQPTALFITRLVVTAVLAYLIALWLLAEPAPVLAPLTALLVVQVSLFQTLRSAVQRIISVTAGVILAVFLVGWLGFTWWSLGVTIAVALLLGRMLRLGDNLLEVPISAMLILQLGSDTAAAERVKETLIGAGVGLLAGLLAAPVRVRPAQEAVDELGRSMQDLLDRMAEGLRAEPDDRTTADWMERSRRLTDDIQEVDQALTEAEESARLNPRTRIGVTPGPGPALRSAMQHLAHSVLGIHALARSMADRTGLLMRDRTGLGAEMWEADVRTRLAVVLRELATATRLYTRAATTSSADDAVRLVTALESRLSQARRCRDDLGRLLREDPGHWPLHGELLVHLDRLIDELRAAGQGPVTQRPGRRRRPIARGARRRVRTRIPILPGAMAERRRNVPSERPPSPQRTSLPEQPTPSERAAPSERGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXC8</accession>
    <name>A0A1H6DXC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90002">
        <property type="protein sequence ID" value="SEG90002"/>
        <property type="gene ID" value="SAMN04489712_12510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="14798" checksum="81DCA9428A84BC0F" modified="2017-01-18" version="1">MSDPYSQGPQQPQYVSGPPQSWTPPQPPPRGKNRGTVVGLVVLAVIVGFIGVAGYLSSKSDPDTAAIGDCVARGSGSSIRVVECTDPASDYKVVGKVPDKTQVQFNISSQRICNPFPTAKSAYWKGESGGKGYVLCLAPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXG2</accession>
    <name>A0A1H6DXG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG89968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89968">
        <property type="protein sequence ID" value="SEG89968"/>
        <property type="gene ID" value="SAMN04489712_1251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011408">
        <property type="entry name" value="Aldehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699:SF211">
        <property type="entry name" value="PTHR11699:SF211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="1"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG89968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="370" mass="39446" checksum="F42CC6B22B927A8B" modified="2017-01-18" version="1" fragment="single">DNGKPIRESRDVDVPLVAAYFFYYAGWADKLEHAGFGADPGPVGVAGQIIPWNFPLLMLAWKIAPALACGNTVVLKPAETTPLTALVFADICRQADLPAGVVNIVTGAGETGRVLAAHPGVDKVAFTGSTEVGKQIARAVAGSRKRLTLELGGKAANIVFEDAPLDQAVEGVVNGIFFNQGQVCCAGSRLLVQESIAEELLERLKARMATLRVGDPLDKNTDVGAINSAAQLAKIRELAQAGEDEGAARWSPACVLPQRGFWFAPTVFTGVAQSHRIAREEIFGPVLSVLTFRTPAEAVEKANNTPYGLSAGVWTDKGSRMLWMAQRLRAGVVWANTFNKFDPASPFGGYKESGFGREGGRHGLEAYLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYU4</accession>
    <name>A0A1H6DYU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90508">
        <property type="protein sequence ID" value="SEG90508"/>
        <property type="gene ID" value="SAMN04489712_12659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG90508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="377" mass="41036" checksum="A448F313066418B2" modified="2017-01-18" version="1">MKSLVPTTLSTEERALQREVRAFLDDRLPPGGHPLGLGMSGEVDPEFSRDLAAQGWVGMALPREYGGGGRTAVERQIVVEELLARGAPVGYHWVADRQSGPSIARNGTEEQRRRLLPGIARGELSFAIGMSEPDSGSDLASVRARAVRHRDGWLINGTKIWTSGAATATHVLGLFRTSEDRRGGLTQFIVESDVAGLTISPIPFIDGTLHFCELSFEDVYVPDTARLGDVGAGWSQNTGELALERGGVDRWMSLMPVLEAWARSPEVRASPVAHVDLGRIVSRLWAFRGMSLSIARLVDAGESPVAEAALVKEMATRFEQESVEIVRRHFGRTPDLDSDDPWESLLARAILVSPSWTIRGGTTEILRSVIAKGLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYZ1</accession>
    <name>A0A1H6DYZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90558">
        <property type="protein sequence ID" value="SEG90558"/>
        <property type="gene ID" value="SAMN04489712_12671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="29123" checksum="D892DEA3512FC533" modified="2017-01-18" version="1">MTTARVWFITGASRGLGRAFTEAALTAGDRVVAAARDLGPLDDLTAAHPDRLVRLTLDVSDRAAVRTVVDRAAAAFGRLDVVVNNAGTMLLGMVEEATEEQIRAQFDVNFFGAVWVTQAVLPHLRAQGSGHILQVTSMGTGGGVASAGFYAASKNALDSLSQALAMEAAPFGIKVTIVQPGGYGTDLFTRGTTTTRPRPEYEPLRARLAEMWGEDAGPDPSTAAPVVMELVDLAEPPLRLIVGAASYDMVQQMDRARTEEYRAWEHLSRKAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ93</accession>
    <name>A0A1H6DZ93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90439">
        <property type="protein sequence ID" value="SEG90439"/>
        <property type="gene ID" value="SAMN04489712_12638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="27646" checksum="196A24D4FC33C64D" modified="2017-01-18" version="1">MADLTTIRLELDGPVGLLTLARPEKLNAMSRRMVAELTSVLEELAADTAVRCVVLAGEGRMFSAGADLDEFRDDFGAAGVDPAATEREARDGARLTAALESPDIVTIAAVHGAAIGGAAAVVAACDLRLFADDARLVVPELAMGLPLAWGGIERLVRDLGPAVTRDLLLTARPLTADEAVARGFAMERVAPGGLLDRARRIAALCATRPRRGTTIALGRIRAVADRSRAEGVDDDAASLAVAAGDPEALAAARAYLASLDSTSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1E8</accession>
    <name>A0A1H6E1E8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">SAMN04489712_12750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90826">
        <property type="protein sequence ID" value="SEG90826"/>
        <property type="gene ID" value="SAMN04489712_12750"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="105"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="182"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG90826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="42035" checksum="6E873B5EB5A25838" modified="2017-01-18" version="1">MPVVGMVGGGQLARMTQQAAIGLGVPLRVLAASPRDSAALVCADVRIGEHTSLADLRSFAKGCDAITFDHEHVPSAHIQALEAAGVACRPSSAALLHAQDKLVMRERLSAAGAPCPAFAPVDPRDPLAAVEAFAAEHGLPVVLKATTGGYDGKGVWILESLGADDRRLVESLSGEGLSLMVEQYVPFRRELAALVARSPYGQGAAYPVVETVQRDGICHEVLAPAPGLDEELAAEAQRLALDIAERLDLVGLLAVELFETGGSAAPGGLLVNELAMRPHNSGHWTIEGARTSQFEQHLRAVLNLPLGSTEPTARYTVMANVLGGDDPDIYPRYLHVMAHDPAVKVHFYGKEVRPGRKIGHVTALGDDLAETRERARHAADYLRWGPAMGPATKERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1R4</accession>
    <name>A0A1H6E1R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91550">
        <property type="protein sequence ID" value="SEG91550"/>
        <property type="gene ID" value="SAMN04489712_12956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="19"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="371" mass="38240" checksum="C3973361B910DFC6" modified="2017-01-18" version="1">METQAAVLSHTAHPRPYTGSRPLRLETVQLDEPGPGELLVAIDAAGVCHSDLSVVDGTRRRPTPMALGHEATGTVKAVGDFVTDVAEGARVVLIFVPSCGLCGQCTGGRPAQCRNGARANAEGSLLSGARRLQHAGVSLHHHLGVSGFARHAVVDRRSAVVIDDDVPAPIAAMFGCAVLTGVGAVINTADVRPGESTVVIGLGGVGLAAVLGARLAHAHPIIALDPVPAKRDLALELGATIALDPADTAALADLLPTGAEVTIEAAGRIPALELAWSLTRPGGRTVSVGLPDPSQRLALPVTDLIGQGRTLLGSYLGDAVPQRDIPRYLALWRAGKLPVELLLTGTRPLAEINEALEDLASGQVVRQVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1S0</accession>
    <name>A0A1H6E1S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase class Ia, DhnA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91522">
        <property type="protein sequence ID" value="SEG91522"/>
        <property type="gene ID" value="SAMN04489712_12947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="31774" checksum="C6865F496F6CC6AB" modified="2017-01-18" version="1">MVAARLDRMFSAGGRCFDVAIDHGMVNEASFLNGIEDMAATVRIVAEAQPDVIQLTPGMVKHLHGVPGRRPALALRSDVSNVYGRELPRHTFSQLIDGIVEMAVVSDAVCVVVNLLQLPDQPELHHQCVRNIAALKRDCERAGMPLMIEPLVMAPNEKGGYMVDGDLVKITALVRQAAELGADIIKADPCTDPAEFHQVVEVASEVPVLVRGGGRETDEVVLERTAEIMRQGAAGIVYGRNVIHHRHPRRIIRALMALVHDPSTPLDTARAILAGDEPLPNGTHPHEAGLITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E245</accession>
    <name>A0A1H6E245_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_13039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91748">
        <property type="protein sequence ID" value="SEG91748"/>
        <property type="gene ID" value="SAMN04489712_13039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="30"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG91748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="35319" checksum="9C75D26B9896542C" modified="2017-01-18" version="1">MLLPTVQFDDEAQCFTSTDNVKTEQLVAAMDRPLSLTFQLTRNCNFRCVYCSEPPGIRTRAPDEVLAMIDKLAGMRRIIFSGGEPMAYKHFWRVLEHAQGKFERIVLSTNASLITRDAAARLRDLVHYVDVTVDGPRRQHNAIRGQYDKVIRGLRRLAEEEIPLSVICVYMGRNKHVINYIAQTGDIFGAKKVKILTTIPKGLSKNLFEDFTTGEELDRLYEHLQAERERNGWKPRITIADWMRIGAGHAILIEPDGRAVASPVWQEPDCIVPFGNLHTQTVQQLWDAFPYKTHHLDKYLERTMIVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3C4</accession>
    <name>A0A1H6E3C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91851">
        <property type="protein sequence ID" value="SEG91851"/>
        <property type="gene ID" value="SAMN04489712_1311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="111" mass="13094" checksum="F282EBC7CE9AA109" modified="2017-01-18" version="1">MSEREYFANVRRRLPMYVIGGRLDRLEAFLDGYDQHAMRHGGPGLQGWKDWLIAKRGQTCNHGWPGHVRHIALPDGWEHWDLPQEQEQIVIDVLFDLLDEYLTEREPDATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3I6</accession>
    <name>A0A1H6E3I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_1314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91859">
        <property type="protein sequence ID" value="SEG91859"/>
        <property type="gene ID" value="SAMN04489712_1314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="137"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="244"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG91859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="404" mass="43436" checksum="A6920425148516A3" modified="2017-01-18" version="1">MSGLEEFRSRVEAFLGARYPRRPEMLRHGQGDDSLVGAAFRDSDDEVGDLQRARDYQRELFDAGLAWLGGPVEYGGAGLGAEERRAFAEIVRRYDVPDVNGLLVGQQIIAPAILAHGSAGQRARLLPALWSGELVGCQLFSEPGAGSDLASLRTRARRTDGGWRVDGQKVWSSGAHLAHVGELLARTSPDPASRTRGLTMFLLGMDSLGVTVRPLRQMTGTAHFCEVFLDDVFVPDDAVLGEVGGGWAVANVSLNSERDNFGDEGANLFIRLLDRLVLLGQEIGATEDPDVRDRLADGYIRHVIGQVLPASLENAVPEVAAAGASLVKLFATDADRRLAQLALDILGPALVADTGAWGTYAWSRVLLGIHATRIAGGTDEIQRNILAERALGLPREARSFQGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4N4</accession>
    <name>A0A1H6E4N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91974">
        <property type="protein sequence ID" value="SEG91974"/>
        <property type="gene ID" value="SAMN04489712_13151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="144"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="461"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="684" mass="74892" checksum="DC9DB3E6549A601B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4P1</accession>
    <name>A0A1H6E4P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92587">
        <property type="protein sequence ID" value="SEG92587"/>
        <property type="gene ID" value="SAMN04489712_13441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="21914" checksum="DDF82AFA88BF9F53" modified="2017-01-18" version="1">MSPKHRRGEATVDRVLTAALDLYAAQGPDALTMTALIAETGVSSGSLYHHFGSVDGLAAALYARCMADLLDAIADALEDARTARAGVQALVRAYLGFVRDNPPAAHFIHASSYAGFLPAHAARIAEAKAPRMARIAAWLRPHVAAGRIVDLPEPLLEMLVIGPVAETARRRLAGDPGIDLAQAARLLPERIWRAVRADPAPPVDPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4S2</accession>
    <name>A0A1H6E4S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91885">
        <property type="protein sequence ID" value="SEG91885"/>
        <property type="gene ID" value="SAMN04489712_13114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="29155" checksum="D87E0FC067C34E88" modified="2017-01-18" version="1">MTLKTTQELMRDSYEYANAAFASLVRFDDAAAVVTGGAQGIGRGIAGRLAELGAAVTLVDVDPAVDAAAAALAEQHGTAVTARTLDVRRSADLAEVAREVLTAGVRRLIWVNAAGIYPSHLLPDLSDEDWDRVVGIDLTATFYGSRAAGLAVRDAGLEGVIVNISSVAGFRVGRPPGLAHYASAKHGVQGLTKALAVELGPYGVRAVAVAPGAVVTEGLVAKFGDLDLEGGTDYFSTRAQEMPIRRPSLPDDVARAVCFLASHAASNITGVVLPVDAGQLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E598</accession>
    <name>A0A1H6E598_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92461">
        <property type="protein sequence ID" value="SEG92461"/>
        <property type="gene ID" value="SAMN04489712_1342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="37" mass="4043" checksum="477E87F260BCA7DC" modified="2017-01-18" version="1">MEAWNDALDADPSSPAPQPANNPWVTRNGDFSDDPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E713</accession>
    <name>A0A1H6E713_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_13914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93492">
        <property type="protein sequence ID" value="SEG93492"/>
        <property type="gene ID" value="SAMN04489712_13914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG93492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="677" mass="71791" checksum="E922BCF3317BB233" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8M2</accession>
    <name>A0A1H6E8M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Holin-X, holin superfamily III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93264">
        <property type="protein sequence ID" value="SEG93264"/>
        <property type="gene ID" value="SAMN04489712_1382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="15635" checksum="6D603334C8BCE7D0" modified="2017-01-18" version="1">MTEAEPGERFEDKSLGELVAQASSGISKLIRAEISLAKMELKVDARKAVIGSGLFFVALAVFAPVIIFIGLGLAYVFIELGVWPWAAFFLVAALYVLVAVLLGVVGVLVVKRIRGAKRTRRTLRDLPSAFHHEDSDRPALAQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAC6</accession>
    <name>A0A1H6EAC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93884">
        <property type="protein sequence ID" value="SEG93884"/>
        <property type="gene ID" value="SAMN04489712_14120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="415" mass="46759" checksum="993AE9D1B96A1343" modified="2017-01-18" version="1">MSRPARQAIVAVYRATFPQAPDWAEGPLPLVHGSIRADTASRSTYYPPRTARLLYGTPEHPRRWHRALRERIGDLTVIGVEALRLNDRPDADGLLIVHLSPGGVQAVDVVRALARRSGTSLPGYDPARLVGDQVRLLPGSPFTLTFVTARGWRLPRLYSHPRYLRWPYLDQWQWALASRSNYRDQPPDPRITRLPEQDRVWISADWSALVLREGMALTGTRPDRGVSDPFYNHAALYARTIYLDAILIGLLQLHGISELEDTLAAVLDGGSPSGMPSLERRLAQFRHQLWWQHLSAHGAPNQFLEAFHHQHRLPERFAQILAEINDYNRLAREDETRNINGAVLLFTLVTVPAGIALALLQVLSVRDLWIFTTVFASCLLLTGLLLATGPARAVLRSMRSPRKQAIAAPTHHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAQ9</accession>
    <name>A0A1H6EAQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG94006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94006">
        <property type="protein sequence ID" value="SEG94006"/>
        <property type="gene ID" value="SAMN04489712_14224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="27800" checksum="5EE44B67A6D0574A" modified="2017-01-18" version="1">MATFVVTGSASGMGAASAARLAAEGHTVIGVDLRDAQVIADLGTLEGRAAAAEEILGLSGGTLDGVAAIAGVGPNLPSAAAVMSINYFGTVALLEALRPALAASGAGRAVVIGSNSASTVPLVDDGLVDLALAGNEEGAREHADAAQAAMPAEITAIVPSIGAYASSKLAIARWVRRTAVTPEWARQGVLLNAIAPGAVLTPLMLGSTGREEDLDADGFPTPMPLGIFGRPEDIAFWVHQFLKPEARYTTGAVLYVDGGTDAAMRPDAQPTPMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAT5</accession>
    <name>A0A1H6EAT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, LacI/PurR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000058">
        <property type="protein sequence ID" value="SEG94998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94998">
        <property type="protein sequence ID" value="SEG94998"/>
        <property type="gene ID" value="SAMN04489712_1581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG94998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="349" mass="36907" checksum="0AF4AF665F52B2F5" modified="2017-01-18" version="1">MTISEPPVRSACARPATGRAPTLAHVAALAGVSPATASRVLSGSAHVSPDARMLVEEAVQRLGYVRRRSAPRTVGPGESVAVVLCADSSRVFADPFYASLLLGVKRELEGGPQVVVLMVGKTEEWRTTAEYLRSGHTAGVVLVGSHRDHPLTLLHAAARGPVVLAGRPLSENRLPYVDADNRGGARTAVEHLVAGGRRTIGTIAGPPDMGPGVDRLAGYRSAAQEAGIDMGGLVSRGDFSQLSGEHAMNRLLDRRPDLDAVVAASDLMAIGAMRALRRAGRRIPEDVAVVGFDDLPIARRVRPRLTTVRQPIEDLGARAARELLALIGGRTATERGVVLKTRLIVRDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBA4</accession>
    <name>A0A1H6EBA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000061">
        <property type="protein sequence ID" value="SEG95037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95037">
        <property type="protein sequence ID" value="SEG95037"/>
        <property type="gene ID" value="SAMN04489712_1611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="11"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG95037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="38300" checksum="B31733C6734F0CE3" modified="2017-01-18" version="1">MSTGYDGRQIVGMDLHRRRSVLVRMTSEGRRLGKARITNSPAALRAEIARAGRRPKVVLEATYGWYWAADTLALAGAEVHLAHPLGVKAFCYRRVKNDERDAADLADLLRMGRLPEAWIAPQDVRDLRELTRYRCKLVAMRTSAKDQVHAVLAKLGIPVRHSDLFGPGGGAWLDGLALPQPYCGKVASLRQLIEVHTGEIGLLEEVIAELLAGHAGYRAIQALPGIGPVLAAVIVAEIGDITRFDRPERLCCWAGLTPRHRESDLKVARGHITKQGSTLLRWALIEAVQKQPVGSPVRATRDRIIARRGTQARNIAKVAAARRLLTLVFYGLRDGHVRALQHPARDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBR4</accession>
    <name>A0A1H6EBR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein, gntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_15017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94713">
        <property type="protein sequence ID" value="SEG94713"/>
        <property type="gene ID" value="SAMN04489712_15017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="14078" checksum="49B3E6207D3BBBE4" modified="2017-01-18" version="1">MAKGPVDRRKPYVRIADDLRRDIASGRYQVGDLLPPAGELAERYGVAGMTVSNAIAVLKEEGLVQTRQGARGARVIAAPDEQDAGEPTPERSEEFQLLFSQLQEMRGQLRRLSSKLDELDERTRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ED64</accession>
    <name>A0A1H6ED64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000054">
        <property type="protein sequence ID" value="SEG94896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94896">
        <property type="protein sequence ID" value="SEG94896"/>
        <property type="gene ID" value="SAMN04489712_1547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="7043" checksum="1B2314199583FE65" modified="2017-01-18" version="1">MDYTEAVLIITRTMCDQQGRMLEATEVKVPANRFEIGHGAELADDPHALFTPEELASEGIALII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S9U7</accession>
    <name>A0A1H5S9U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46778">
        <property type="protein sequence ID" value="SEF46778"/>
        <property type="gene ID" value="SAMN04489712_101112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF46778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="12944" checksum="1C367543FD86321E" modified="2017-01-18" version="1">MTDRSDQSDDVLDEAAGLLDGLRRWMRAPGGERTGDVWERAVGQDSPHIAVECRYCPLCRAMAAARASGGDVEGRLLEAARSLLAAAGDFLDGLERSRPPCTGTGREGPDGDSADIRRAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SG01</accession>
    <name>A0A1H5SG01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49529">
        <property type="protein sequence ID" value="SEF49529"/>
        <property type="gene ID" value="SAMN04489712_101194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="43"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="33645" checksum="DAD3AAAAD70F312C" modified="2017-01-18" version="1">MTQNAANRASDIGSPQELARLLDSCGYLTDDGLATAAYLALRMRRPLFLEGEAGVGKTALAKSLAQVLDTPLIRLQCYEGLDAAQALYDWDFPRQLLHLRTAEAAGVTDVARLESELYDRRFLIARPLLRALETSTAQRPSVLLVDEVDRADDEFEAFLLEVLSDFTISIPELGTVRAAEPPVVVLTSNRTREVHDALKRRCLYHWLEHPSYEREVAIIRRRLPQADRRLAGQVARAAQRLRAEDLLKPPGVAESLDWTEALVALGARDLDPATAAVTLGAVLKYREDQQRVTARGLDALLNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SQQ1</accession>
    <name>A0A1H5SQQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52181">
        <property type="protein sequence ID" value="SEF52181"/>
        <property type="gene ID" value="SAMN04489712_101295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF52181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="456" mass="48211" checksum="C7B21431FCE6FDDF" modified="2017-01-18" version="1">MRESVVPAVRELRDAGLRVLLPGDNGYDTARQPWRRLVEHRPALIAEAAGSREVQAVVRAAGAHGLPITVQSTGHGAVRACDGGLLLRTSAMNGVRVDPARRTVRVGAGAVWGDVVTAAAPFGLAPLSGSSPTVGVVGYTLGGGTGWMSRRHGYAADGVLGAEVVTADGEMLTVRGDEHPDLLWAMRGGGGGFALVTALELPLYPVGPIYAGMAVFGFDRAAQVLARYREWAPEEPDESNTAITMMRMPPSPELPEPLRGRRVLALRVFYLGEADDAERMLAPLREAAGAPLVDGLRPIAYADTSTLLRPPPPPSAIEERLELLDDLPGDAVDAMIGVVEDGGPVAAVDVRHWGGAMARPPEGAGPAGHRDVPFSAMFGAEAERPEQVDAVRSAVRDAAARIGPYTTGGTFLNFLTDPDRTAAAFTPQDYRRLAEVKKRYDPANLFAGNHVVLPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SWK7</accession>
    <name>A0A1H5SWK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54930">
        <property type="protein sequence ID" value="SEF54930"/>
        <property type="gene ID" value="SAMN04489712_101393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF54930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="24197" checksum="9DBD22AF5B853989" modified="2017-01-18" version="1">MTGTMRVPRSRGALSGILLVLLGLWGGLIPFVGPYFDFAFTPDEPWHVTGDRLLLSVAPAAATVLGGLVVLAGANRAVALLGAWLATLGGAWFVVGGPLSVLWDAAGVGAPLGGEGRQVAEQLSFFAGLGAAVIFFGALALGRFSVVGVREARLSEEMAEYDAHRDRDHARDHGRDHERGPFEPPASRDTVPTPVHPQGRYARRPDQVPPPAEPADHRVAGEPGGNHGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T2Y9</accession>
    <name>A0A1H5T2Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56451">
        <property type="protein sequence ID" value="SEF56451"/>
        <property type="gene ID" value="SAMN04489712_101439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF56451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="23987" checksum="D2371AB70622B59F" modified="2017-01-18" version="1">MIKVVLADDQRLVRAGFRSILEDEDDIAVVGEAADGEQAVAACRELRPDVVLMDIRMPEVDGLAAARRIAADPRLADVRIVILTTFDLDDYVYGALRAGATGFLVKDTEPAELIHAVRVAARGDALISPSVTRRLIAEFAARVRAPRPDPRLNALTEREREVMGLVAAGLSNDEIAARLVLSPATAKTHVSRIMTKLGVRDRSQLVVLAYESGLVSPGWLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TF78</accession>
    <name>A0A1H5TF78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61449">
        <property type="protein sequence ID" value="SEF61449"/>
        <property type="gene ID" value="SAMN04489712_101595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF61449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="48" mass="5108" checksum="5085EDDE00C3D336" modified="2017-01-18" version="1">MYTLLWLLAVVLVVAGIYVIVARRDILWGIVLIVVGLLVGPGGVSIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5THM0</accession>
    <name>A0A1H5THM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61507">
        <property type="protein sequence ID" value="SEF61507"/>
        <property type="gene ID" value="SAMN04489712_101597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF61507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="26914" checksum="9E65DABD203BE835" modified="2017-01-18" version="1">MTAMIVAVDRPAGPSLFTLALVELRKMVDTRAGRWLLAFVALLGVALVGVVLFAAPRHIRTMPELYSASLAGVGILLPVVGVLSVTSEWSQRTALATFTLVPGRGRVLAAKVVAASLLAAVCVAACAVAAWAGRALGAVLDRTDAGWGVPPQMLATTLLAAVLGVLAGVAFGMVFLNSPLAIVMSFLLPIAWSVLGETVSALEGAAQWLDTGRTTAPLVEAGGRLTPRAWAQLATSQAVWLLLPLLIGFFRVTRREVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TLA4</accession>
    <name>A0A1H5TLA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63539">
        <property type="protein sequence ID" value="SEF63539"/>
        <property type="gene ID" value="SAMN04489712_101665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF63539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="383" mass="40703" checksum="C38724AD662775FF" modified="2017-01-18" version="1">MSTTPDEATADPSLLCEQARRLAESGEPTEAARLFGRVLELGEGPHRARAALGLAVVLDDVGDVAGAREADWTAIGTQDPEYGPRAAYHLALLHERAGERDEAGRAWRIVVDFGNPGYLPPALLALAQLADDDGDFEAARDWWEQVIGTGHPQYAPVAAHDLGQRLLERGEPARAQRVLAGALRLIDRESSPYAYARLATCIGIAYLDQAIGAFDAVLDDEEAATDPDVGPLATELLARTLPLRGRAEEAREVWARGLARPGVAGQVRARLRREFAEPAGRGEEAGTSWWEPLVESAVADGSLPALTGEAFGALDHMYAVAALRLAQGPADAGDAYEALGQAAEVPGGYPWGGLLHESFTDRARRALGPDAPNVPDVPDPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TNE7</accession>
    <name>A0A1H5TNE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63631">
        <property type="protein sequence ID" value="SEF63631"/>
        <property type="gene ID" value="SAMN04489712_101668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046041">
        <property type="entry name" value="DUF5999"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19462">
        <property type="entry name" value="DUF5999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF63631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7183" checksum="AF145A552FCFEBF3" modified="2017-01-18" version="1">MCPHQPPCPSHDAPDRDAARTLARRPEQGWSLLCNGVVVFDDTGELLPDGEVIAPHRPSVRSATPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TW23</accession>
    <name>A0A1H5TW23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C and Quinol oxidase polypeptide I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67006">
        <property type="protein sequence ID" value="SEF67006"/>
        <property type="gene ID" value="SAMN04489712_101768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF67006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="23204" checksum="B33DBE3CF14BF4AD" modified="2017-01-18" version="1">MTLTRPAADSAPAALRRSPSKGSILVGWLTSTDHKVIGYLYLITSYAFFLIGGVLALVVRAELAQPGLQLVSGEQYNQAFTMHGLIMLLLFATPLFVGFHATFLVQHWLGVAGFPRRYADYAAEFTTLNVVSTVGAFLLSVSTLPFVWNVWRTWRTGARVETDDPWGHCGSLEWATSCPPPRHNFTAIPRIRSERPAFDLHHPHLALKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TZE8</accession>
    <name>A0A1H5TZE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67568">
        <property type="protein sequence ID" value="SEF67568"/>
        <property type="gene ID" value="SAMN04489712_101785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF67568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="28062" checksum="535FE818EDCB8F35" modified="2017-01-18" version="1">MSTAERVHIRPVAEAVLAARGAEQPLAGRVALVTGGSRGLGREIAIAFAAAGADVAVVSRKKDACVELAEELADATGRRVSAHAAHVADWDRLTGLLDEVDSELGPVDILVNNAGIAPLYPSLDEVSEELFDKVIGVNLKGPFRLMAAAGRRMAANGGGVILNISSIASVRPTAADLPYAAAKAALNTLTAGFAQEYGPTVRVNTILAGPFFTDISRAWDLAAFDEMAESWPLHRGGRPDEIVGAALYLCGPSAGFTTGALLAVDGGRLAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U2T2</accession>
    <name>A0A1H5U2T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69343">
        <property type="protein sequence ID" value="SEF69343"/>
        <property type="gene ID" value="SAMN04489712_101849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="425"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF69343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="516" mass="55337" checksum="8C7AA06C9F69C314" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UTH6</accession>
    <name>A0A1H5UTH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78306">
        <property type="protein sequence ID" value="SEF78306"/>
        <property type="gene ID" value="SAMN04489712_10215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF78306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="27470" checksum="E032A25CD433C209" modified="2017-01-18" version="1">MPDSTNADRIDATAAALSAYRSRAHPDTRPGDDTGLGQAVLLRDLLVDLMHHAEAMATDFGLLVESADRTHRRQTHRDLPDQTDEAAQVAGTGSEVIDLLTNDITDAVRGLTTSIARTGLTDIQSACRLLDGLTQAARDLAHAFPQISSYLQREHAAGKLADIHHDPKQAIDLATLYLKVAEGVTGSLAGSLTRTRQAITGMHPAPDQPHHQPRPSELARQDFPASAPDLTTPPALQQEPASPSNPHTSRRNIPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UYA7</accession>
    <name>A0A1H5UYA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolases family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80142">
        <property type="protein sequence ID" value="SEF80142"/>
        <property type="gene ID" value="SAMN04489712_10292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF80142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="460" mass="51659" checksum="41F489FDBA337874" modified="2017-01-18" version="1">MNPVGHHRPAPAPPPPGRLRPRRWLAAVAFLALLALAGTVAYVLLREDRPVRVPPKEIGKIGAPYGAPWTVWGFTHTDRSADVGPASARVARALDDRPMIQNQHIMGWGAYNPEPVPGRYDFTALDRRMDYIRRTGGTPVITLCCAPDWMKGGRPGDTDWRKLEVAPLPQHYDDFARLAATVARRYPYVRHFAVWNELKGFYDRRNGRWNHEGYTQLYNQVYDALKAVNPAIHVGGPYVPMYSHVGGTGSALRGEWGSVDQIALDAVEYWLAHKRGADFVTVDGPTASDDRDVHPDEVTALDKFVAINKWLRARTDLPIWWNEYYIEPHGDPWSEDKRAAMHAAALIDYARAGVSTVLYWNRIPLDGDRTCKGCLWVTTSVRDGGTPGRMLGVLQSFAQWFPAGTPMIDVRASSRRVRVLAQPRKIVAVNTSGHQVHTHVGDTEITLAPYEVRWLDRNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V2Z7</accession>
    <name>A0A1H5V2Z7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate--cysteine ligase EgtA</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthase</fullName>
            <shortName evidence="2">GCS</shortName>
            <shortName evidence="2">Gamma-ECS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">egtA</name>
        <name evidence="5" type="ORF">SAMN04489712_102124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2 3">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81108">
        <property type="protein sequence ID" value="SEF81108"/>
        <property type="gene ID" value="SAMN04489712_102124"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02034">
        <property type="entry name" value="EgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017809">
        <property type="entry name" value="EgtA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035434">
        <property type="entry name" value="GCL_bact_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011556">
        <property type="entry name" value="Glut_cys_lig_pln_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378">
        <property type="entry name" value="PTHR34378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378:SF1">
        <property type="entry name" value="PTHR34378:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017901">
        <property type="entry name" value="GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03444">
        <property type="entry name" value="EgtA_Cys_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR017901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF81108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="417" mass="45392" checksum="1A4447B339CF21BC" modified="2017-01-18" version="1">MSRLTVAEVYEHVRGVCFKNGPPGKVGAETEWLVVDRRDPRAHVAVDRVRAVVDGAGPLPGRSTVTYEPGGQLELSTPPFSGLMDLHAALSRDLACVRERLAADGLELAGRGVDPVRSPRFQADHPRYGCMRDYFRHGGFESAGLAMMCSTASVQVCLDIGADPADTLRRWRLAHALGPVLVAAFANSPLRAGRRTGLRSTRQAIWNALDPCRTLPVLDEGEETADPRDAWARYALDAPVMLMRPRPGSADGWTGAPGMTFRQWLDKGEPDLEDLTYHLSTLFPPVRPRGWLELRMIDALPVPYWPVPVAVATALLEDPQATRTAEDAARPVAGRWAAAARDALADPALALAARRCFAAALEALPRLGAADLVPLVAGYARRYVDRGRCPADDLDPSTPVLTPRRNRRGAADHHRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V5N6</accession>
    <name>A0A1H5V5N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-cysteine desulfhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82068">
        <property type="protein sequence ID" value="SEF82068"/>
        <property type="gene ID" value="SAMN04489712_102156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="7">
        <location>
            <begin position="13"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF82068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="36616" checksum="1FF7F30DD5A8796C" modified="2017-01-18" version="1">MTTPDLTAFPRVRLGHWPTPLERCDRLSAELGGPRIWIKRDDCTGLAAGGNKTRKLEYLLGRALAEGHHTVVTFGAVQSNHARQTAAACARLGLRCELLLTRSVPRSDELYETSGNVLLDGLLGARVRIVDDADDIAAALEEIGPAYVIPPGGSNAVGALGYVGAALELLTQIQPPPETARPDQGAGPQEQEATRLESKVGPAGAVDRVVVATSTAGTAAGLAVGLAEAGSAAQVEAVAVYRPAEETRAVVEELTAETARLLGVPVPEDRVTVHGDWLGPGYGVVTPEMSEAVRLFARTEGVLLDPVYSGKAAAALVGLVRAGRIGADETVVFWHTGGLPGLFVYPDAFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V784</accession>
    <name>A0A1H5V784_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component sensor histidine kinase, contains HisKA and HATPase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83080">
        <property type="protein sequence ID" value="SEF83080"/>
        <property type="gene ID" value="SAMN04489712_102194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="292"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF83080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="496" mass="54147" checksum="E54FB8289490D0A1" modified="2017-01-18" version="1">MRTRTDLDTADLEWLHALVSDWQLLADLSFADLVLWVPERGAVPGAQVPGWICLAQMRPTTGPTAYPEDLVGMVVRTGRRGLIDVAWRERRIVREGDPEWGSGIPVREESIPIRRGDKILGVIQRSTNLSSARTPSRLELTYLQSASDLAQMIAEGRFPDPGGEPNLLRSPRVGDGLLRLDKAGRVTYASPNAQSAFRRLGMAADLAGEPLGEVTQRLVDTGEPMEESLTRVLSGATAREAEIEAHGSVVQLRTIPLVVSGTRIGAVVLVRDVTELRWRDRELMTKDATIREIHHRVKNNLQTVAALLRLQARRLRVPEGRAALDEAVRRVGSIAIVHETLSHTPDELIDFDDIADRVITMAGEVSAPETQVVPKRTGAFGVLPAQIATPLAMVLTELLQNALQHGLPHRYGELEVRATREEIGPAHLEVVVSDDGVGLPPDFDLEDTTSLGLQIVRTLIVGELGGHLEFRARPGGGTEVVVNIPLTAPQRPADHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V7V5</accession>
    <name>A0A1H5V7V5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin carboxylase</fullName>
            <ecNumber evidence="1">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.14" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83264">
        <property type="protein sequence ID" value="SEF83264"/>
        <property type="gene ID" value="SAMN04489712_102201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF83264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="444" mass="47856" checksum="72D7F189D1B30D6A" modified="2017-01-18" version="1">MFESVLVANRGEIASRVIHTVRAMGLKAIAVYSEADAGLPFVAEADEAILIGPPQPARSYLDADRVLEAARRTNAQAIHPGYGFLSEDAGFAERVIDRGLVWVGPPPLAIARMGDKINARNLMMEAGVPVSPGVWEPVPDAATAVAEAERIGYPVMVKAAGGGGGIGMGAARDEAELLLAYETARNRAARFFSNSDILLERYVEGARHVEVQILGLADGTVVALGERDCSVQRRHQKIVEETPSPGVSPQLRARMLDAGVRAGETVGYRGAGTVEFLVDPAAQDFVFLEMNTRLQVEHPITELVTGIDLVEQQLLIAAGEQVTFTSVEPHGHAVEFRVYAEDPVRFLPRPGDIKIWEEPVGEGIRIDAGYAEGNAVTPFYDPLLAKLCVHGADRAAALRRAEQAVGAFQIEGLQTNLPFFTELLGDPDFVAGTYDTGLVDRMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VI74</accession>
    <name>A0A1H5VI74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86746">
        <property type="protein sequence ID" value="SEF86746"/>
        <property type="gene ID" value="SAMN04489712_102326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="74"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF86746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="14799" checksum="FB313D05EE4B3BE9" modified="2017-01-18" version="1">MARKVSEVMTPAPVAVPPQCSLVQAAEQMRRHGIGDVLVAEDDRLCGLVTDRDIVVRAVAAGRDMAATPVSEVCSPELVTLTPADDAETAVRLMREHAVRRIPVVDGDRPVGMVSLGDLALERNEHSVLADISAQPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VIX3</accession>
    <name>A0A1H5VIX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87170">
        <property type="protein sequence ID" value="SEF87170"/>
        <property type="gene ID" value="SAMN04489712_102339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009287299" evidence="1">
        <location>
            <begin position="44"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF87170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="364" mass="38758" checksum="1FB3A0B6AF2275BA" modified="2017-01-18" version="1">MQRRTARAQMAAKQHRGKISLLIIAVMAVVAGVSTAMATGAAAAPSADGPPSLTLVAPGAGQAQKASEPCFSGGTVCHSTNPDVTLRLHSNGDTSGCTFHGTFNWGDGTSTNYNVSGGPNGKVLISRTHHYRVPGVYHGTWNAVVDSGAGCYSSSGTFQFTLDCGPTQQSGPAWTSRFPTSRAVADLGNAFESDATAFIRAMRQAGIKVTVHATYRPPQRAYLMHYSWLIAKRRINPENVPAFKPTGRQQSVDICWVRVKDGKTDLAASVAAAQSMVNAFGIDPELTVAPALTSRHTTRQAIDMSTTWSARSITIRNAAGRAVTINTTPHTALNARLIAVGATYDVIHFRPPVRDKNHWSTDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VMX4</accession>
    <name>A0A1H5VMX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88366">
        <property type="protein sequence ID" value="SEF88366"/>
        <property type="gene ID" value="SAMN04489712_102376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF88366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="36913" checksum="4F3F7E4B310FB877" modified="2017-01-18" version="1">MTAKTGKDVTEDAETTEVAEAAVEESEAPRAESRPARKKVRRVRVIEVIDDGEDDDDLSDVLEALDQEEPDPPAPGKGGPAKRVSAEAASAKAAPEPGPAEAEAETEEAAGEIQETAEEEAEAEAAEPKPAKAKPKPAKAKPKPRRVKAASAPVPLRDGSLILKVVAVVLVAGLATSTLLLWKSWRTLAQKEDARREVTKMVTDYGNVVLSYDRTDLQGSVARAQSYLTGDALTKSKQTNVAQLQKSMDEGEFTLVSKTSQVYVASADGRFASAVLVFDISVKSPTGTQDVTRNYLSLSLVRQDGTWKISQQKPAGRESDDNAGAVPDLNGQQTPKTPEKSAKPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WA07</accession>
    <name>A0A1H5WA07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_102642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96265">
        <property type="protein sequence ID" value="SEF96265"/>
        <property type="gene ID" value="SAMN04489712_102642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="258"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="325"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF96265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="650" mass="70641" checksum="BF117E519B043503" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X1M2</accession>
    <name>A0A1H5X1M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tight adherence protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_10344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05443">
        <property type="protein sequence ID" value="SEG05443"/>
        <property type="gene ID" value="SAMN04489712_10344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009288962" evidence="8">
        <location>
            <begin position="26"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="95"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG05443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="657" mass="68496" checksum="C1904E13F8780154" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X375</accession>
    <name>A0A1H5X375_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/Exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06201">
        <property type="protein sequence ID" value="SEG06201"/>
        <property type="gene ID" value="SAMN04489712_10369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289013" evidence="1">
        <location>
            <begin position="29"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG06201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="413" mass="44256" checksum="8C00C022A9F70F30" modified="2017-01-18" version="1">MRHTGLRAVSVAGAGLALAAVTAVPALADGGHRQVRFATFNASLNRNAEGALVADLSTPGNAQARTIAETVQRTRPDVLLINEFDFDAEGRAARLFQDNYLSVGQNGAAPIGYRYRYTAPSNTGIASGLDLNNDGKVVTRPGEAGYGDDAYGFGAFPGQYGMAVYSRYPIDERRIRTFQKFRWKDMPGALLPDDPATSAPADWYSPAELDAVRLSSKSHWDVPVKVGGRTVHFLVSHPTPPTFDGPEDRNGRRNHDEIRLWADYVRGGKAARYIYDDRGRRGGLAPGAAFVIAGDQNADPLDGDSVNGAVNRLLEHPRVDASVIPTSAGAPEAAALQGGANAAHRGDPAHDTADFADGAPGNLRVDYVLPSRRLRPVRGGVFWPVAADPLSRLTGVFPFPGSDHRLVWLDVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X9P6</accession>
    <name>A0A1H5X9P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-binding domain and a Fe-S cluster-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08481">
        <property type="protein sequence ID" value="SEG08481"/>
        <property type="gene ID" value="SAMN04489712_103156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="452"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG08481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="610" mass="65677" checksum="157F3A119445AC76" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XL40</accession>
    <name>A0A1H5XL40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12468">
        <property type="protein sequence ID" value="SEG12468"/>
        <property type="gene ID" value="SAMN04489712_103304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG12468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1109" mass="119794" checksum="AA0D16396D1FBFA3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XLC1</accession>
    <name>A0A1H5XLC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12220">
        <property type="protein sequence ID" value="SEG12220"/>
        <property type="gene ID" value="SAMN04489712_103294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG12220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="58" mass="6446" checksum="A31D934F6785553D" modified="2017-01-18" version="1">MGELSRTIEERLSDAYASLRLARADGDAYLADIRQSEIEELRRIAANHDIGVPSPDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XRT0</accession>
    <name>A0A1H5XRT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14137">
        <property type="protein sequence ID" value="SEG14137"/>
        <property type="gene ID" value="SAMN04489712_103368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG14137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="43" mass="4795" checksum="DF96B83FAF81639A" modified="2017-01-18" version="1">MPDIITTVLAKALVMALEALLTRLFVHLVQMARYRMALVPNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XS78</accession>
    <name>A0A1H5XS78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14538">
        <property type="protein sequence ID" value="SEG14538"/>
        <property type="gene ID" value="SAMN04489712_103384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG14538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="478" mass="53480" checksum="782C418109A5D13A" modified="2017-01-18" version="1">MSAPPTPDLPPEVIAALHRAAMPDFVRWQQMIRTAGGCEQPVRLRGERFTLDAQTGELIESYRTDDEPTGFLLTACGNRRASRCAACAQVYRDDTYHLIISGLTGGKSVPESVSAHPRVFLTLTAPSFGAVHTRREKGGQVQMCRPRRNRPLCRHGRPEGCGRRHQEADPAIGQPICIDCYDYAQAVLWNAHAPELWRRLTLTVPKKITAELGITHKALREQARISYARVIEYQRRGLIHFHAVIRLDGPDGPDQPPPPWASTDLLERALRAAAAEVAVAVPHPDGESLPLTLGWGGQLDVQPIHVAADLDGIADKHVARYIAKYATKGAEDAGTVDRPIRYASQISTLKVSEHARRMIWTCFTLADLPEYHELRLRHWAHMLGYRGHFSTKSRRYSVTLTELRQARADHAAAQARQRDGRPEPDPNRPTIKVGRWKYTGSGLRHGEHLWAAQARERIQTARRIRQEATDSDHQAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XSE5</accession>
    <name>A0A1H5XSE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="ORF">SAMN04489712_103390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14719">
        <property type="protein sequence ID" value="SEG14719"/>
        <property type="gene ID" value="SAMN04489712_103390"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="123"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="238"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG14719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="33360" checksum="31AE1F7C7E2A5509" modified="2017-01-18" version="1">MTAAGAPATGLRVPDALPGARILAFGDYQPARVVTNDDLAATMDTDDAWIRSRVGIVERRIAAADETIADMAVHAGGKALAGSGLAPGDIDLVIVATCSAETPLPSHAATVAHRLGITAPGAFDLNAACAGFCYALATASSAIRDGSARNVLVIGAEKMSQWIDWTDRSTAIIFADGAGAAVVTGAQAPGIGPVVWGSAGDLADKIRIEDRASFLVQEGQAVFRWATTAIAPVAAAACEQAGISPQDLAAFVPHQANLRIVESIARRLKATNAVVADDIVHSGNTSAASIPLALARMIERGEVPSGAPALLIGFGAGLTYAAQVIQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YJJ6</accession>
    <name>A0A1H5YJJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23707">
        <property type="protein sequence ID" value="SEG23707"/>
        <property type="gene ID" value="SAMN04489712_10425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG23707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="29650" checksum="4C3CFB68001C2ABF" modified="2017-01-18" version="1">MSRDDGQGPPDGVHTDRPVSARVWNYWLGGKDHYDVDREAGEKVARHVPGIAAAARGDRLFLGRCVRYLAGQEGVRQFLDIGTGLPTADNTHEIAQRVAPQARIVYVDNDPLVLAHARALLMSTPEGATSYIDADVRDPGKILREAAATLNLGEPVALMMLAILHLIADDDQVRRILREFVDALPSGSYLAISHACTDVEATRVAVRTWNDSDTPHPVKPRSRAEITRFFDGLELVEPGVVSCSRWRYEPNPWGEPEEIMTFGGLARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YLV2</accession>
    <name>A0A1H5YLV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24565">
        <property type="protein sequence ID" value="SEG24565"/>
        <property type="gene ID" value="SAMN04489712_10463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="53"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG24565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="368" mass="39395" checksum="BD3AB73714B092F2" modified="2017-01-18" version="1">MRTPATGGHTGAEADEHPQAPEPEPAQTTPTDPSVNAHRKEDAMKAWSWDRYGPPDVLTLKDVAEPDIAPDQVLVRVRAASVNPYDWRHAGADPMLARLSIGLRRPKPGLILGADLAGVVERVGEEVTGLQPGDEVFGEVSLGSFAEAVAVPQDRLAVKPARLTFEQAASVSMAAHTALQGLRDDGRISAGQRVLVNGASGGIGTFAVQLAKTFGAEVTGVCSTRNVELVRSLGADDVVDYTREDFTARQGRYDLLMDIVGDRSLAKLRRPLTSRGTLVLVGGISARGGLLGPAAQMLRGALVSPFVRQRITGVRWNPNSADLQFLAGLMEKEQLTPVIDRTYPFAEIPEALHYIKRGHARGKVAITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YS39</accession>
    <name>A0A1H5YS39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26848">
        <property type="protein sequence ID" value="SEG26848"/>
        <property type="gene ID" value="SAMN04489712_104152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG26848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="125" mass="14279" checksum="BC0FF4C99A4F07E5" modified="2017-01-18" version="1">MTACHWHGFSNRMPAADTTKYSFTIFENLPAGWPPRVVRDWLRHPPSVVKCHADTPEEAVAWLRREYEDSENPLDSVAHATPKQERFTRALISLRGGDDLCWGFWIGTHTYLTLALIGMDQCPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YS55</accession>
    <name>A0A1H5YS55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Flp pilus-assembly TadE/G-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26166">
        <property type="protein sequence ID" value="SEG26166"/>
        <property type="gene ID" value="SAMN04489712_104122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tad" evidence="1">
        <location>
            <begin position="4"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="129" mass="13493" checksum="3379B63FFF16695E" modified="2017-01-18" version="1">MFAVIISLVVLVFFGAVVDFERKLEARHDAGIAAQEAARAGAGQVDLDRAYGGGRFVVDRQAAIRAAQRYLRAGGYSGAVTVAGPRAIRVHVTVTKSALFLPVIGVSTLRAEAEAVADLTTGVEGARQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z2F5</accession>
    <name>A0A1H5Z2F5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ORF">SAMN04489712_104283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29815">
        <property type="protein sequence ID" value="SEG29815"/>
        <property type="gene ID" value="SAMN04489712_104283"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG29815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="236" mass="25903" checksum="465202962CE22DBE" modified="2017-01-18" version="1">MTRASLDKRPADVAAMFDGTAERYDLLNSLMTGGLDRRWRRAVVAAVDARPGERILDLAAGTGTSSLPFAEAGAHTVACDFSLGMLSVGTRRTRDLPAGRRPRFVAGDALRLPFADGAFDAVTISFGLRNVADTDLALRELRRVTRPGGRLLVCEVSHPPNMLTAFGHRLHLRYGLPLLAKVSSNPDSYRYLAESTLAWPRQQELARRLREAGWDSVRWRNLTFGVAAMHHAVNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z395</accession>
    <name>A0A1H5Z395_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30801">
        <property type="protein sequence ID" value="SEG30801"/>
        <property type="gene ID" value="SAMN04489712_104325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG30801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="345" mass="37147" checksum="2C88973AC3C7FFF9" modified="2017-01-18" version="1">MLAIIIGGGLVVILIIAAAFFVLLGNNDKSPTERLAAAARSLSSARALTLKGTFGTERIEGEVKVTASGRVTGPVTWSGDRVTLLSTDGNLFVKADRSYWSKNLTTTDVDDLPGSGEHWGKVEPTKLTFDFKQYATPSALAAKMRSITKFSVRSDVETTLRGRDVIKITTLSGTYYLSADDDELLRVESISPAVNADVTAQTGSAASATVNELRTRIGELKDAWDATKSPRLQKIDGCKNESAAGCTVRVQLWTSGASGGTTQVNVYVWITATTKTGRRLGDCTATATTTGLTSVWTQCRVSGPQWRSFYNTQNTTLRWWMQGMPVAIGATQSEIQAMQAALDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z9L4</accession>
    <name>A0A1H5Z9L4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="12" type="ORF">SAMN04489712_104423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32720">
        <property type="protein sequence ID" value="SEG32720"/>
        <property type="gene ID" value="SAMN04489712_104423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG32720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="21234" checksum="BCE542F0C14B0F5D" modified="2017-01-18" version="1">MAAQRRGGGQGGDRRDGRRDDRRGGADKGQSYIERVVAINRVAKVVKGGRRFSFTALVVVGDGNGTVGVGYGKAKEVPAAIAKGVEEAKKHFFKVPRIQGTIPHTSQGEAAAGVVLLRPASPGTGVIAGGPVRAVLEAAGIHDVLSKSLGSSNAINIVHATVAALKQLNRPEEIAAKRGLPLEDVAPAAMLRARAAGSEPRAEAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZD91</accession>
    <name>A0A1H5ZD91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine/homoserine efflux transporter RhtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34493">
        <property type="protein sequence ID" value="SEG34493"/>
        <property type="gene ID" value="SAMN04489712_104501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="174"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG34493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="36108" checksum="0F379D52BB38CA16" modified="2017-01-18" version="1">MASAGKQGYLDGLPISTVFLMPMAPSRTSLGTTLCLISAAGFGMSAVFAKETYQAGAGVQTMLTVRFALAALLFWALVAWRRPAFPAGRTLLTCVGLGAVGYACQATFYFGSLARIDGSLAALLLYTFPPIVTVIAIALGRESMDRRRLTALACSVLGVLLLLGSGVRPGAAGGVALALAAACTYALYLTVANGLPEDLDLYLVSAIVCTSAAVSLALISVSTGSWQPPAQPDGWLWTGLLAVFSTFVPIICMLAGMRVVGASTAAIVSYAEPAVTVASTALVYGERLAPTQFLGGAVVLVAVLILSSDRAWPSPALRRAFRRNATPALTDEHVEPHPSPAVAGRAGAGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZEL5</accession>
    <name>A0A1H5ZEL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34919">
        <property type="protein sequence ID" value="SEG34919"/>
        <property type="gene ID" value="SAMN04489712_104523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG34919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="16340" checksum="3CDEB4E94C95C7B7" modified="2017-01-18" version="1">MSIEPGQDTRPGPEGPGTPPGPGAPQDVERAGRRALWLGLAALVMIFVPVLSIFAAIPAVAAIVIGVKARRAARQGRRPAPGALPGIILGGVGALFFAFGIGAQLYLLEETNRYSKCQNAANTIEEGRQCKERLADDIEKKFGLPEGTIDGDSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZIY8</accession>
    <name>A0A1H5ZIY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_104553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35617">
        <property type="protein sequence ID" value="SEG35617"/>
        <property type="gene ID" value="SAMN04489712_104553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="262"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG35617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="574" mass="60994" checksum="27266E85DC888819" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A206</accession>
    <name>A0A1H6A206_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41977">
        <property type="protein sequence ID" value="SEG41977"/>
        <property type="gene ID" value="SAMN04489712_105110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG41977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="180" mass="20824" checksum="40DA394D31598429" modified="2017-01-18" version="1">MTTRPYRLDQPLEQRRTLLPKPHYDPESFGRLSERFARFLGTARFLVYMTGFVAVWIGWNILAPPALRFDSYPFIFLTLMLSLQASYAAPLILLAQNRQGDRDRVQYEQDRARGERTVADTEYLAREIAGLRQALSEVATRDFLRSELQQTLKELDARHDGRHEPHHRVPPEGGYASHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A3H2</accession>
    <name>A0A1H6A3H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42912">
        <property type="protein sequence ID" value="SEG42912"/>
        <property type="gene ID" value="SAMN04489712_105167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG42912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="153" mass="16500" checksum="1F99E6858385BF39" modified="2017-01-18" version="1">MVGRFATGVAIVSTVADGVDHAMTINAFTSVSLDPLLVLFCAEKIARLHDAVLKSGGWAVSVLPEEAEDLSQWFATRGRPLDDRLGGHPFERGAHTGAAIFDESVASLECRTHAVHDGGDHSIVVGEVLAVQTPAPKNRRPLLYYEGHYRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A3S1</accession>
    <name>A0A1H6A3S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MarR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42386">
        <property type="protein sequence ID" value="SEG42386"/>
        <property type="gene ID" value="SAMN04489712_105135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_38" evidence="3">
        <location>
            <begin position="5"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG42386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="27575" checksum="6C099FAC7F386A91" modified="2017-01-18" version="1">MPGGRLTHAERRQIALGLADGLAYAEIARGLDRPTSTVTREVMRNGGPTGYRADLAHRATERRAQRRRPASSRGAQSAPRPHGHDAEALREYEETFTDVLIASGVPKMMARVLVCLYTTDSGSLTAAELVQRLQVSPASISKAIAFLERHTLVRRERDERRRERYVVDGDLYYQSMMASVRDITRQVEVARQGADVLGPDTPAAVRLENIARYLDFVGESLARAAEQAREILYTPPKEALDGGANDHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABU9</accession>
    <name>A0A1H6ABU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45517">
        <property type="protein sequence ID" value="SEG45517"/>
        <property type="gene ID" value="SAMN04489712_105307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG45517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="79" mass="8318" checksum="949190D0F1C38126" modified="2017-01-18" version="1">MSLDETARQLKLAVHDAQVAFDCVGLGDLERAQEHVITARAAVDAAALSLQQALHSLSPEEASAQGEQAVAALEERHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ACJ9</accession>
    <name>A0A1H6ACJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_105322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45765">
        <property type="protein sequence ID" value="SEG45765"/>
        <property type="gene ID" value="SAMN04489712_105322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="10"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="341"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG45765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="456" mass="48314" checksum="27CB80604801E15E" modified="2017-01-18" version="1">MAVHNAEEVDVVVIGMGPGGEDAAGRLAEAGLSVVGVEARLVGGECPYYGCVPTKMMIRGANLLAEGRRIPGLAGDATVTADWTQVAKRIREEATDSWDDRVAAERFTGRGGRLVRGYGRITAPGEVTVGDQVFRPRRGIVLNPGTEPVVPPIDGLAGTPFWTNREAVRAEAAPGSLVVLGGGAIGTEMAQAFSRFGTRVTVVESRDRLLAVEEPEACDLLREVFEREGITVRTGARATAVRHADGAFTVDLGGETVRGEALLVSTGRRTRLRELGVGAIGLDADARTIETDEWMRAAEGVWAIGDVTGKGAFTHMSMYQADIVVRDILGQGGPPADYRAVPRVTFTDPEVGAVGLTEAQARERGINVRTGLTRIPESSRGWIHKAGNDGFIKLVQDADRGVLVGATSAGPAGGEVLSALAVAVHGEVPVERLRHMIYAYPTFHRAIETAVKDLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AG76</accession>
    <name>A0A1H6AG76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47372">
        <property type="protein sequence ID" value="SEG47372"/>
        <property type="gene ID" value="SAMN04489712_105417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG47372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="448" mass="48277" checksum="D9E3B3A532C3B5B7" modified="2017-01-18" version="1">MNDELTEALKGTLKTAARQAPAPAPDLLHQVHGRHRRRRRAQAGMAAAAVLVTLGGSGALTSVLGSAEDPARPAAQSKPGPLKAVTVGKPVPVERLWPQAVRPLPERLPGGRAYRAITLLDDDTLLVTTESSFEKTDQILTYDLRTRRTTQITRTPVPSGSDLFPSGFSVGDGRIAWWVRYKQGGRHTVEIWAAPLSGGDAYRVAATQHDLSEDASVRRLTIGGGKVYWSMAGRNTSSQGVYESQGVYEAPVSGGGTARQVPGTTGFQVLAWPWIGGPGLTGPMDAERAKPGEVFHRTLRDLRNGRTTKAGLATIKGSWNCGITWCVAHKSLPKQWSGGHGPVPETYLQRRDGTGGRMFRMLGGRRHLMQRLDGFLAYDRFLPYMAEPAGGSVQWLLYDTQTGDVASVAVPQDGGGYSAIGLFRDPAERIVEVDSVNGRLLIDLAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJA1</accession>
    <name>A0A1H6AJA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas1</name>
        <name evidence="10" type="ORF">SAMN04489712_105478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48482">
        <property type="protein sequence ID" value="SEG48482"/>
        <property type="gene ID" value="SAMN04489712_105478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019858">
        <property type="entry name" value="CRISPR-assoc_Cas1_HMARI/TNEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43219">
        <property type="entry name" value="PTHR43219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG48482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="36554" checksum="8AE760F24E61ED48" modified="2017-01-18" version="1">MPAAGRTYWLTTPCRIRRKDQSLLIERESGGNVHIPITDVRDIVACEPVDVNTAVVSLLNRHRISIHLLGHYGDYAGSLLTSDTSTSGETVLAQARVAMDEEAGLQIARDLVLATAFNIRRVIDRDLLKTPYEVLQKSAAAATGQAGLMGAEGIYRRSAWDVLDTKLPAWLQLNGRSRRPPANAGNAFISYTNGITYARVLTALRLTPLHTGIGFLHSTMERQRHTLVLDLAEVFKPLFAERLLLRLSNRGQLKPHHFDTGTNHAMLSEAGRKLVVQTIRDELGVTVHHRTLGRKVAYEELLYLEALRLTRRLLEGTPYKPFRIWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJX1</accession>
    <name>A0A1H6AJX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49039">
        <property type="protein sequence ID" value="SEG49039"/>
        <property type="gene ID" value="SAMN04489712_105511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG49039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="81" mass="8652" checksum="32A2A3D47A6D0A96" modified="2017-01-18" version="1">MIPTLILFGLLLGRWWRSSLIAAGLGWPILLVTSDVMSVEPGLLGASGLAMANTGVGVLIHQGILLMVRTRRRSRSPDSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AMN0</accession>
    <name>A0A1H6AMN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetolactate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49317">
        <property type="protein sequence ID" value="SEG49317"/>
        <property type="gene ID" value="SAMN04489712_105526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="185"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="383"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG49317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="544" mass="57799" checksum="29FD8AA8B20C2A1B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B0P9</accession>
    <name>A0A1H6B0P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53885">
        <property type="protein sequence ID" value="SEG53885"/>
        <property type="gene ID" value="SAMN04489712_106123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG53885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="26127" checksum="24CA20DB4981AE53" modified="2017-01-18" version="1">MTQQASRTAIVTGAARGIGAAVAKRLARDGFAVAVVDLDADACKPVVTEIESAGGRALAVGADVSDEQAVEAAVQRIAAELGAPTVLVNNAGIIRDNLLFKMSAGDWDAVMNVHLRGAFLMSRAAQKHMTEAGWGRIVNLSSTSALGNRGQANYSAAKAGLQGFTKTLAIELGKFGVTVNAIAPGFIETEMTAATAARVGVPFEDYKKGAAAQIPVRRVGRPEDIAHTVSFFVSEDAGFVSGQVIYVAGGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2Q4</accession>
    <name>A0A1H6B2Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_106206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55131">
        <property type="protein sequence ID" value="SEG55131"/>
        <property type="gene ID" value="SAMN04489712_106206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG55131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="381" mass="41114" checksum="1119F31D65C01A91" modified="2017-01-18" version="1">MTVDPWHTPERIALRRMVRDFTVREILPHLDQWEEDGELPRSLHVKAAEAGLLGAGFPESAGGGGGDTIDALIVAEEMIQAGGSGGLVASLFTHGIALPHIVKAGDPDQIRRFAVPTLAGEKIGALGVTEPDAGSDVAGLRTTAVRDGDDYVVNGAKLYITSGVRADFVTTAVRTGGPGFGGISLLVIEKGTPGFGVSRSLRKMGWLCSDTAELSFTDVRVPAANLVGPENGGFVQIMQNFVAERLSLAVQAYAHAQRCLDLTLAWIRERETFGRPLSSRQVIRHKVAEMARQVDVARTYTRRITERYVAGEDVLTEMAYAKNTAVQACEQVVNEAVQLHGGMGYLRESEVERHYRDIRILGIGGGTTEIMNEIIAKRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2Y2</accession>
    <name>A0A1H6B2Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Formyl-CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54972">
        <property type="protein sequence ID" value="SEG54972"/>
        <property type="gene ID" value="SAMN04489712_106193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG54972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="43069" checksum="9BD4B80470C90028" modified="2017-01-18" version="1">MTELPLSDLRVVEMGQLLAGPFCGQLLGDFGAEVVKFEPPGTGDPMRDWGREKPHGKSLWWPILARNKKSVTLNLRTEEGQRLARRIIAEADVLVENFRPGTLERWGLDPETLWADNPGLVVTRVTGYGQSGPYAPRAGFGSIGEAMGGIRYVTGDPDRPPSRAGISLGDELAGTFAALGTLVALHARSRTGRGQVVDSALYEAVLAMMESLLPEWELAGYQRERTGSVLPNVAPSNVYPTKDGPVLIAANRDTIWTRLAEVMGRPELAADERYATHGARGANAEELDELIAEWTAGQESAPLLETLHANGIPAGLTYRAKDMLDDPHFRAREAIIRLAHPEFGDFPMQNVVPKLSNTPGTVRSLGPELGEHNDEIYRGLLGLTPEEIEALTASGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B489</accession>
    <name>A0A1H6B489_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynamin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55669">
        <property type="protein sequence ID" value="SEG55669"/>
        <property type="gene ID" value="SAMN04489712_106249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="714" mass="74962" checksum="8F8AB0365EB8F192" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B701</accession>
    <name>A0A1H6B701_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56304">
        <property type="protein sequence ID" value="SEG56304"/>
        <property type="gene ID" value="SAMN04489712_106302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293413" evidence="3">
        <location>
            <begin position="25"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG56304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="34106" checksum="50DEAE2B299177E3" modified="2017-01-18" version="1">MKGKVVVVTGASSGIGLATALAFAAREASVVLAARRKGVLEQVAADCEEQGGSALAVPTDMTDLKAVEELARRAVERFGRIDVWVNCAAVGIYGPFTETPLEDFRRVLDVNIMGYVHGARAVLPYLREQGEGVIVNVASIAGVLSQPYAHAYSMSKFAVRAMSASLRQELALEGARGIKVCTVLPAAIDTPFFQHAANYTGRKVRAMPPIYTPERVAHAIVDLVRVPRREVVVGPAGRGLVLQSRFTPGLVERMMARQVDRTHLSRKEAAPATSGSLYAPKDDRGTVGGGWHGKRKTAVRRGMALAALAGGAAGARRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BD49</accession>
    <name>A0A1H6BD49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58580">
        <property type="protein sequence ID" value="SEG58580"/>
        <property type="gene ID" value="SAMN04489712_1072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG58580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="46716" checksum="19DE211C627C6ED5" modified="2017-01-18" version="1">MVAGQETLGQRIRALRIRQGVSQAQLAYPELSDSYISLIESDKRVPAPSVIELLAAKLNCSATYLVSGVSEEVVDELRVTLDYAEIALQNGAAEEARARFADVLANTDAVALPELLQQARWGHALALEAAGALEEAIAELRRLTAETSAEADLEQWAKVHVALSRCLRERGDISAGVEVAEEALRRLVASGAESTDGAVHLGSSLLAAYIERGDLVRARQLAEQLIARAERIGSPLARMAAYWEAAYIAEVRGDYEEGLTLAERALPLLGVLDDSRNLSRLRMVYAGLLLRAHPEQAEQARELLLRIREQINSSSAGEIDVALCLIELARAETALGRPADAVTLTHEALDLLGDSPRRASAGALTVLGEAYVRLGRTEDAVEVLTRAATHMEEMESSREAAQAWFDLAELLGETGAADGPRLGAYRRALACAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BDW3</accession>
    <name>A0A1H6BDW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58734">
        <property type="protein sequence ID" value="SEG58734"/>
        <property type="gene ID" value="SAMN04489712_10716"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293654" description="Glutathione hydrolase proenzyme" evidence="6">
        <location>
            <begin position="51"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG58734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="633" mass="67448" checksum="3E69DBA54D57E0B6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJA1</accession>
    <name>A0A1H6BJA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60437">
        <property type="protein sequence ID" value="SEG60437"/>
        <property type="gene ID" value="SAMN04489712_107131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="491" mass="50985" checksum="B2D5B0EB11CF31FF" modified="2017-01-18" version="1">MAEAGTDEVEPLATAMEGPDGRFSVELQAASPTIAAEDFAGVVVVLSAGPDGVRYLAVFDETGGAGFAAVPAGAWTLDVVAGGAAGGGSAAGAVPLPAVRPDPGAVAASTDRYRVMSPAGVLYAVEQPGPESPFVLEVVAPPERAGLLAVRYTAHDGTRRHLLVPVLPSRTGGARARVRLDGFAPHLPWEAAGRMDPAALTENDQAAVAASRRPPWTPPPPARDGGCSPPRTEPQVSARMSRIGAISPHRGEGSPAHPGGHGARRSSRLTARSAHRRARPDGLAVLVALPGARARRSPGEPAAPVVGPCSILLTDVVGFGGPGRTDEDRRVIRAALYRLLREAFEAAGLTWEDCHHEDRGDGVLVVIPPTFPAAASVDPLVPLLAAGLRRHNAQAAPGTRFRLRAALHVGPVTADAEGVCGEAIIRTARMLDAPVLRRRLAGTGACLGFITSAFVYDSVVRHASGLVDPGGYRRVELRVKESALTAWMHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNR5</accession>
    <name>A0A1H6BNR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PucR C-terminal helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62333">
        <property type="protein sequence ID" value="SEG62333"/>
        <property type="gene ID" value="SAMN04489712_107289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="299"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG62333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="361" mass="38700" checksum="05AAAF782C4A9676" modified="2017-01-18" version="1">MTGEVRGLRLTVRDLLEVPRFRLRLVAGAAGLDRPVRWAHSTELLDPSSYLRGNEVVLTVGASLSDPGRCVEFARAVSAGNASAIGYGIGDVTAQVPRALAEECERLGLPLLEVPQEVPFPSFTEWLAERLAATREERHDREEMGRLLGLVRDGLALPEALRDRVERAGLSGETLVAMAVPVRVLPEGVDAGVGGLLGFEDGTAVLVVDGEERAVTLAKTWSGPAGVGSPGRLKHLPRSISEACTALESARRSGGVVRAADLATFQVLLERLDPEWLTPFVDQIARPLADHDVAHSGRLVETLRAFLATGGSVGAASRSLDLHPNTLRHRLSRIEAITGRNPLSFEDRIALAVAMRAVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYZ5</accession>
    <name>A0A1H6BYZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenocysteine-specific elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65918">
        <property type="protein sequence ID" value="SEG65918"/>
        <property type="gene ID" value="SAMN04489712_108149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015191">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004535">
        <property type="entry name" value="Transl_elong_SelB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09107">
        <property type="entry name" value="SelB-wing_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00475">
        <property type="entry name" value="selB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG65918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="585" mass="62070" checksum="6B878E32C14BD3A2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2M4</accession>
    <name>A0A1H6C2M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurite resistance protein TerB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66947">
        <property type="protein sequence ID" value="SEG66947"/>
        <property type="gene ID" value="SAMN04489712_108240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16313" checksum="ADAD1175295F24C0" modified="2017-01-18" version="1">MALWNKLRESTQTMQAQLMAKKNELKSGAFRDASMAMCALVAAADGSVDPAERQRTASLIATNEVLQNFPAHDLQHRFDDYLGKLTTDFAFGKVGLLQTIGKVGKKPAEARAVIQIGIIIGGADGHFDDTEKAVVREACHAVGLNPAEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C321</accession>
    <name>A0A1H6C321_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67045">
        <property type="protein sequence ID" value="SEG67045"/>
        <property type="gene ID" value="SAMN04489712_108248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="373"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG67045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="609" mass="65412" checksum="D139B35A0ACF5F07" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CA17</accession>
    <name>A0A1H6CA17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_109112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69752">
        <property type="protein sequence ID" value="SEG69752"/>
        <property type="gene ID" value="SAMN04489712_109112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="86"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG69752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="452" mass="46667" checksum="93F02A4FBAF71F94" modified="2017-01-18" version="1">MLSLALRSLRHRATAFVASFLAMLLGAVMIMSFASMLDTAGGTGVSDANVETLVTMASVVGGWSLILVLFAVTSTLSLAVRQRATEMALLKSIGATPAQLRRMILGETAVLAVAAVALAVLPGMLGGRALLALLIDTEQVAPDVTHVFGPAALSMGCGITFVAAVGSAVLTARRTTGLRVTESLMDATAEPRRMSRKRLVGGIVFLLLAADLAVVTATVMHGEGSDAMQTAGQTSIWASIGFALLGPVLVRRVAGLPAAPLERFGGAAGHLTVQNVRQRAHQMAGALMPIILFTGIATGTLYMQDVDSAAIAAEGLLKNDEQKSIETLNFVVIGMVVLFAAIMLINTLVATTTYRRGEFGRQRLTGATPGQVLAMVTLESAVLTVTGVLFGAVASLFTILPFTFARTDTVLPDSGPGTFLAIVAVAAVLTMAASLATAVRALRIPAIEAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CC49</accession>
    <name>A0A1H6CC49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Group 1 truncated hemoglobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_109162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="4">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the truncated hemoglobin family. Group I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70337">
        <property type="protein sequence ID" value="SEG70337"/>
        <property type="gene ID" value="SAMN04489712_109162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019795">
        <property type="entry name" value="Globin_bac-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016339">
        <property type="entry name" value="Hemoglobin_trunc_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002030">
        <property type="entry name" value="Globin_Protozoa/Cyanobacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01213">
        <property type="entry name" value="GLOBIN_FAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002030-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG70337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13219" checksum="34A4389FF393EC9C" modified="2017-01-18" version="1">MGETAGKTIYEAIGGEDALIAVVEDLYRRIFADPALQGFFTSANMPRLKGRQVEFFGAALGGPMTYTGASMRDAHAGMAITPEHFNAVAGHLTGALLDAGVPQATVDEIIGLVAPLADDIVTTPAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRW9</accession>
    <name>A0A1H6CRW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75770">
        <property type="protein sequence ID" value="SEG75770"/>
        <property type="gene ID" value="SAMN04489712_11181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="27187" checksum="526803C211A443A7" modified="2017-01-18" version="1">MGVLQRFERRLEGMVEGAFARAFKSELQPVEVASAVQREMDERAAIVAAGRTLVPNDFVVEISQADGQRLAVYADSLSQELANLAREYAKEQGYSFVGPVRVRFESAGDLATGMFRIRSGVIRGSTVEGGEIRRPASDVPQGRTGGFAGRPRLLVTTAQDVGPSTQQTYDITTPVTLLGRGTDCDLRLVDPGVSRHHAEIRVEGPEIVLVDLGSTNGSFVNGNPIRRVTLVDGARVTMGRTTLVFRRDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSH7</accession>
    <name>A0A1H6CSH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75565">
        <property type="protein sequence ID" value="SEG75565"/>
        <property type="gene ID" value="SAMN04489712_11157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="15264" checksum="0965BD31F8C52AB0" modified="2017-01-18" version="1">MTAENGRPGPPVTSISIVVLILARRVEAELNAALGPLGLTVGRLGLLGHIARVPGASFTELARMSGVTVQSVHGAVKALTAAGLVRDHNARAGSASTLELTPQGARLLEEAERAAAEVDDRMFGPDADPARRRIGAAVRAMFSAQPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CU27</accession>
    <name>A0A1H6CU27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76183">
        <property type="protein sequence ID" value="SEG76183"/>
        <property type="gene ID" value="SAMN04489712_111133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027273">
        <property type="entry name" value="Neocarzinostatin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49319">
        <property type="entry name" value="SSF49319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295218" evidence="2">
        <location>
            <begin position="31"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="26382" checksum="2925A01C783CCC3A" modified="2017-01-18" version="1">MRWGHRVLTAAAAVVAAGLSSVHMAAPAHAASLRVSPSAGLDPGGQTISVSGSGFDPRRNNRFGVYVVFGPRGADFHKNANAYGAAVWVHPGGKGAGGGQAPMTDSGAFSVSLTVKAAYTDGDGRSVDCTATRCYVMTFAAHGVADRSQDTVIPVSFKGSGGSGGSGDSGGSGPGSGSGPGSGSGPGTGRGLTSTPVPAGTAAPQNSVSQSSPASPATPMTVQPFRNTASSAPAQSSWPFWLATGGAITAGLTARNLVRRRRLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVM5</accession>
    <name>A0A1H6CVM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_111201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76743">
        <property type="protein sequence ID" value="SEG76743"/>
        <property type="gene ID" value="SAMN04489712_111201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG76743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="476" mass="49794" checksum="4FC6344BA9C6EE38" modified="2017-01-18" version="1">MTSGPGALIAGQYRLAEELGRGGFGVVWRARDERLHRNVAAKELFPPTYPGGDRRDERHRRGLREARSAARIGHPGAVTVYDVVEHDGCPWIIMELIDGRALNAIVKRDGPLSPRRAAQVGLEILGALQAAHAAGVVHRDVKPGNVLIGERRAVLTDFGIATIEGDPVLTHSGFVMGAPAYTAPERARGEPAVPASDLWSLGATLFYAVEGHRPYPGANANATFHAILSREPPVPAHAGRLAPVITGLMRHDVADRLTAAQAVVLLQQIIDLPAGAEHDPGSALPPTQIRTEPTHPGLRLPARTGRGVLTAAAVTIALAVGTGTLLWLEGPGGADAARPARHLNAAVIGSAPSTVLPQVPGKPNTVAFSPDGRTLATAGADGTILLFDAAERRRLATLTGHGHAVLTVAFSPDGRTLASGGHDGTVTLWDIERHRRLTTFSPARGPVTAVTFSPDGRSLTATAHDGTVRLGVSASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZI5</accession>
    <name>A0A1H6CZI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78442">
        <property type="protein sequence ID" value="SEG78442"/>
        <property type="gene ID" value="SAMN04489712_11278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG78442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="347" mass="35055" checksum="FD92AE8B6D4488AE" modified="2017-01-18" version="1">MTSVGIDRAPDAALVRRPARVRFLWLLVTAGVLAALMVASVALGSRDVTWSDVWAALGGADDTLEQAAVAKRMPRTLLAVVIGAALGLAGCVMQGVTRNPLADPGILGVNMGASLAVVTAVAFFGLTSPTGYIWVAMAGAAVSAVFVYAVGSLGRGGATPLKLALAGTATSVAFASLVSAVALPRNDIAGSFKLWQIGGVGGASYERIGQVLPFLAVGLAVCLLSARGLNSLALGDELAAGLGERVAVIRAMAALGAVVLCGASTAVAGPIGFVGLVVPHACRLLVGVDHRWLLPFSALTGAALLTAADVAGRVVTRPADVEVGIVTALIGAPFFIHIVRRQKVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D094</accession>
    <name>A0A1H6D094_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78690">
        <property type="protein sequence ID" value="SEG78690"/>
        <property type="gene ID" value="SAMN04489712_112112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="244" mass="25425" checksum="AE5E71C1B14ECE70" modified="2017-01-18" version="1">MALITGASGGIGAATARTLARRGVDVWITYSADEDGARRTAEYCAAQGVRTALSRLDLRSPEDARRLVAQVHGEWGALHVLVNNAGVCPYTAWPDIEPDEWDTVMDINARGTFFLIKEAIALLRRAGGDRAIVNVASLAGQVGGISTSVHYAASKAAVLAMTRSFARLLAGEGIRVNAVSPGPVSTAMTDALDPAVRDGLTGSVPLGRLGRPEDVAHAICLLASPEAAFTTGATYDVNGGLRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0A9</accession>
    <name>A0A1H6D0A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78841">
        <property type="protein sequence ID" value="SEG78841"/>
        <property type="gene ID" value="SAMN04489712_112131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="90"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="23111" checksum="E5840C705A9CACE8" modified="2017-01-18" version="1">MVVQIPRTSLQLRSNDINRIVSVPFSARTGVAAVLWNHLVQLMRHAHEYTTVDELGLARVTVDLVEAACAHRLHVHMPQSLLSGKQALITEILGFIQQSLGNPELCPESIAAAHQISTRYLHKLFQEKGTTVASWIRHRRLEQCRHDLANPQLGTRPIYAIAMHWGFTDGAHFSRIFRATYGTPPKDYRNNMLKSAAHRMHADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2A4</accession>
    <name>A0A1H6D2A4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved DNA-binding protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79432">
        <property type="protein sequence ID" value="SEG79432"/>
        <property type="gene ID" value="SAMN04489712_112215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="146" mass="16161" checksum="19530A3AF625A237" modified="2017-01-18" version="1">MLNFDPDRFQLEDLDKVLAQSQEIVGRIEAAQGRLEEIRGIGEAADGHIRVTCNGQGRVEQIELNPRAMRLDSQTLAEQLTTGVNAAQDDAQRQIGELLGEAMGGVGFDPGTAVDQDRIRKQLDSLTDSFAREMDVRAQDVQRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3K5</accession>
    <name>A0A1H6D3K5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79375">
        <property type="protein sequence ID" value="SEG79375"/>
        <property type="gene ID" value="SAMN04489712_112206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="97" mass="10520" checksum="5CF407C3764598D5" modified="2017-01-18" version="1">MTDYTKVNFGAMQQAQADFTLAYRALVDELDDLEATLERSLSQWEGDAVQAYWEAKAKWDAAAAHIGNVLNQLGVVIGEAHSNYSAAEQANAGIWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5X1</accession>
    <name>A0A1H6D5X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80661">
        <property type="protein sequence ID" value="SEG80661"/>
        <property type="gene ID" value="SAMN04489712_113125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="14692" checksum="6A6DB0FD6594191C" modified="2017-01-18" version="1">MRSNANITFQCAFHVVWCPKYRRRVLDGPIEARLKEIVREVVAEKGAWLVELEVMPDHVHLLVEVDPQFGVHRLVKAIKGRSSRVLREEFPALKSRLPTLWTNSYFVATVGGAPLDVVNKYLENQKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D601</accession>
    <name>A0A1H6D601_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase YjhB, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80175">
        <property type="protein sequence ID" value="SEG80175"/>
        <property type="gene ID" value="SAMN04489712_11332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="21185" checksum="EAF792A79F3FC9DC" modified="2017-01-18" version="1">MRHGDEQVIRRLDSRIVYRNRWMTVREDRIERPDGSPGIYGVVEKPDFALVIPAENGGFHLVEEYRYPVGRRTWSFPQGTFPDGADGDPELLARTELAEETGLRAGRLEHLGHLHCSHGTSGQGFNVFLATDLVAGEHAREHEEQDMRQRWFSRGEFWELVAAGRITDDSTLAAYALLMRHEGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6L7</accession>
    <name>A0A1H6D6L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80921">
        <property type="protein sequence ID" value="SEG80921"/>
        <property type="gene ID" value="SAMN04489712_113177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="910"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="978" mass="105518" checksum="705346D9A22DB8B8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDX0</accession>
    <name>A0A1H6DDX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82736">
        <property type="protein sequence ID" value="SEG82736"/>
        <property type="gene ID" value="SAMN04489712_11574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="184"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG82736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="364" mass="37194" checksum="9AF5D6339E76CE59" modified="2017-01-18" version="1">MVVTPLREVPLPPEWGIGLSLKDESAQPSGSVKHRLLRAAFVQALAAGQITEGGTVVMASAGPAAVAGAYFARMLGLDFVVVVPRSTRPEKVAAIEAAGGRCHPYHPPAAIYQEARRLAADTGGFHLDHFAAAHAIDWRGVTSTDGVRGGKVTGGGHAGDGSAGYGDGVFRGGDVRGGAVEGGAGGGHIAGEIFEQLGRSPEWIVAGAGTGATSATIGRFLRYHGYETRLAVADPENSAYFPGWASGVSDYATGMPSRIEGIGRPRMEPGFLPSAIDLVVPVPDAAAVGALAHLRALTGIAAGGSTGTCLWAAWRLIDRMRAEGRRGDVVVVMGDAGAAPVLDGDAYAAAIGRFLETGSLDVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGI3</accession>
    <name>A0A1H6DGI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83716">
        <property type="protein sequence ID" value="SEG83716"/>
        <property type="gene ID" value="SAMN04489712_11654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="39" mass="4207" checksum="3367588B143012CA" modified="2017-01-18" version="1">MSIAGDDGKKSRHDFERACGDQRLAEFVAARTARAKIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIG3</accession>
    <name>A0A1H6DIG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_117105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84981">
        <property type="protein sequence ID" value="SEG84981"/>
        <property type="gene ID" value="SAMN04489712_117105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="406"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="498" mass="52981" checksum="B05E598C4AD70F78" modified="2017-01-18" version="1">MNLAMILDMVADGMTDRVLLGGRSGGLTGAGLRARAVAGAGFVASAGADRLVYLGGNGPVFPVALLAATLAGVPFLPLNYRLSAEQLDEVMSRQRAPLVVTDTPERVPGAGTVGIEEFLRLPAAGPAPRSAYDIDAESIAVLLMTSGTTAAPKSAVLRHQHLVSYLFGSVEFASADETDATLVSVPPYHIAAVANALSNLYSGRRVVYLDHFTAAGWLDTVEREGVTHAMVVPTMLVRIVAELKARGRRAPAHLRSLSYGGAKISGEVIEEALRLFPHTGFVNAYGLTETASSIAVLGPEEHREAAASPDPAVRARLGSVGRALPAVQIEVHDPEGRPCAPGQVGDIVVRGAQVAGEYVEAGSLVREDGWFPTRDRGHLDEDGFLFVQGRADDTIIRGGENIAPAEIEDVLARHETVLECAVAGVPDLEWGQRIAAFVVPRPGRRADPAELREWVRERLRGSKTPDDIVLLDELPTTPTGKILRRELVEIVRDGADTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKQ6</accession>
    <name>A0A1H6DKQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA helicase HerA, contains HAS-barrel and ATPase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_118129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86007">
        <property type="protein sequence ID" value="SEG86007"/>
        <property type="gene ID" value="SAMN04489712_118129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF853" evidence="2">
        <location>
            <begin position="340"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1004" mass="108929" checksum="296BD79171E6270B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DM46</accession>
    <name>A0A1H6DM46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86278">
        <property type="protein sequence ID" value="SEG86278"/>
        <property type="gene ID" value="SAMN04489712_11940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="324" mass="36461" checksum="A026D9DC9BF0AEC9" modified="2017-01-18" version="1">MKKTEAELLENQWDVANMEVDPEVLASYVKYDVDEKRAVATITFDRPDRLNAIPVAGFERVGDLVREAEADDRVKVIVFKGEGDHFGTGADASELGHYIGYKSGTDKASRRRPAQRQRILPDRNVLTSGFTRPIIESLKATICQVQGYCYGGHFQIALSADIVIATPNARFTHPAFRYLGPAPQDMYHWIEKVGLTTMKDVMLTMRAIGAEEGERKGLITKVVEPDELEKWVNDYAEAIAVMPLDSLMMGKSMMQIILEARGKGLGAMTGWVGHGWATNVRFEEGDWNFLKQRREKGVAKALEERDRLVAPYFRLSETRSSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMC5</accession>
    <name>A0A1H6DMC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86358">
        <property type="protein sequence ID" value="SEG86358"/>
        <property type="gene ID" value="SAMN04489712_11961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="138"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="29284" checksum="DFB3E16F9ADD92C8" modified="2017-01-18" version="1">MTDPTFRPGEAVWVELCTPRPEKAEDFYRALLGWSVRHERLGDSTYRMCSVDGRDVAGISEGALHGGRPRGWLTYFAIDDVHGAAHKAAALGGELVTAPWYLPAAGTGATVIDPFGAAFGLYQGEARAGVQMLNLPGALCWNELNTGEPQKSVSYYQSLFQYGTESRSDTPTGQPYTVLTLGDVPVAGVLELDNKWPNLVPSKWLPYFSVTSLDEAVARTSELGGVPTVGPIDGPNGRLHLVKDPGGHTVCLIQLENGLRPDYVSSPQAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPT4</accession>
    <name>A0A1H6DPT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87240">
        <property type="protein sequence ID" value="SEG87240"/>
        <property type="gene ID" value="SAMN04489712_12095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="223" mass="22659" checksum="C53F49F3EF5F6E7D" modified="2017-01-18" version="1">MLSPTTLRPYPPVPACAQAVPGHNRWHPDIPGVAEVITGGAVRLECEGRPPGEEAVLCGPIVVIGAEAGDVIAVDVLDVGRSDGRYSPFGHPGVIGCAPAAPGVRAVGVPAAGPDGALLGRCRPGLAGYERVAAEAVPTAARGREVVGCSIAPLTAGSRILLPVHARGAKLSVGDLHFPAPDTADCADAPLPGWIDLRINLTKRGVERFGITAPMLLPDPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTD2</accession>
    <name>A0A1H6DTD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88642">
        <property type="protein sequence ID" value="SEG88642"/>
        <property type="gene ID" value="SAMN04489712_12250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="418"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="512" mass="55958" checksum="4B8010214F0F64B3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUZ2</accession>
    <name>A0A1H6DUZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid CoA ligase FadD32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89101">
        <property type="protein sequence ID" value="SEG89101"/>
        <property type="gene ID" value="SAMN04489712_12321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="587" mass="64038" checksum="37CA881DF856A5E2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVD7</accession>
    <name>A0A1H6DVD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88713">
        <property type="protein sequence ID" value="SEG88713"/>
        <property type="gene ID" value="SAMN04489712_12264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="90"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="437" mass="48271" checksum="A58C294C8012B85C" modified="2017-01-18" version="1">MRFQALNRMVRLSALPLGIAGRAGLASGLKVLGRLTDESALELHERTADQLFEVLGGLRGGVMKFGQVLSVYEAVLPPSISDVYRERLARLQDAARPESVDMVYRVMAQDIGPTWQDLFASFEFDAAAAASLGQVHRAVWHDGRSVAVKLQYPDAREQLLGDRDLLVFAMRWFTSLVAPELDGRALAVELMDRIAEELDYEHEAQAQSTFRSGFSTDSDFHIPEVILQNGGVLVSEWIDGTPLAQIISSGSQTERDRAGLLLTRLMFSGIPRCGLMHGDPHPGNFRLQDDGRLGVLDFGAVHHHSPGTESPLQKWMRIHLADDSEQLLHILRELEFLPPGIRVDAERLKDLFARTGAPVHTDLFKFDAAYLRDALGGLTASMPVGLSLAFPPNLVQAQRALGVAIGVLCQLEAEVPFRDEGIRWLSPTLQNQSHSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWP9</accession>
    <name>A0A1H6DWP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89757">
        <property type="protein sequence ID" value="SEG89757"/>
        <property type="gene ID" value="SAMN04489712_12454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="317" mass="33740" checksum="833DA99DEB7F8BA3" modified="2017-01-18" version="1">MVTPRNVPGVTFQNGRVEVHGHRGARGLRPENTLPGFAYALELGVDAIEFDVGLTADGVVVVNHDQALSPLTTTDTAPATPGDPLFPYVGRDIRDLTLAQIRTVDAGVRRIGPGQDGDPLILTQLPLPGTRLPTLAEVCELLHGLDGICPAVELKTDPGWPDDEIRRFVVAVAEVLDAFGLLARSRFLAFDWRVLAEARSHAPQAARVALVERKTLAAGTGWLAGLSPDDPTAAAVAAGASVISPEHHLVTSQLVHDAHGLGLPVAVWTVNDPGDMARFIEYGVDAIVTDYPDRLHQVLTSYDLPRPAPCTPAAHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXD8</accession>
    <name>A0A1H6DXD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90012">
        <property type="protein sequence ID" value="SEG90012"/>
        <property type="gene ID" value="SAMN04489712_12513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG90012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="11692" checksum="5B365E278A54131C" modified="2017-01-18" version="1">MCVAYVVVTIATIAANAAIAVADLAGARFVLANSAEVGLPRSWIPPLGWLKAAGAAGLTLGLLGLRPLGIAAAAGLVLFFLGAVIAHIRARVFHNIAFPGAYLALAIGSFTLAVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXZ9</accession>
    <name>A0A1H6DXZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argR</name>
        <name evidence="12" type="ORF">SAMN04489712_12399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89465">
        <property type="protein sequence ID" value="SEG89465"/>
        <property type="gene ID" value="SAMN04489712_12399"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="10">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="11">
        <location>
            <begin position="96"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG89465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="168" mass="17867" checksum="C819ABEE0719DD69" modified="2017-01-18" version="1">MTTPMTKAARHARVIELLTRHPVHSQGELARLLAEEGLEVTQATLSRDLVEIGAVKLRADDGSLIYAVPGEGGERIPRTRIGNAESFHGRLARLAQELLVSAEASANLVIVRTPAGAAQYLASAIDHAEWPTVLGTVAGDDSILVIARDPQGGQALADALLRLTERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY47</accession>
    <name>A0A1H6DY47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="6" type="ORF">SAMN04489712_12426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89683">
        <property type="protein sequence ID" value="SEG89683"/>
        <property type="gene ID" value="SAMN04489712_12426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG89683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="22573" checksum="5370778CBCCDA9EA" modified="2017-01-18" version="1">MTSPSKKGEEREGPVIRDRRRIDPETGEVREQAAEAAAEPAAGSAPPSAPSDEETAALQAQLDERTADLQRLQAEYVNYRKRVERDRVAVREQALANVLTELLPILDDIDRARDHGELTGGFKSIADALDATLGKLGLERYGEKGEPFDPTVHEALMHSYSADVTETTCVDVLQSGYRIGERIMRPARVAVAEPEDGSGGEDDSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZE5</accession>
    <name>A0A1H6DZE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type branched-chain amino acid transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90469">
        <property type="protein sequence ID" value="SEG90469"/>
        <property type="gene ID" value="SAMN04489712_12647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296354" evidence="1">
        <location>
            <begin position="28"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="49"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="410" mass="43046" checksum="3EB486B359ED9E80" modified="2017-01-18" version="1">MRLIRPAQVVALVAALALATACTTSNESTGSETTGIQGATGKAETAAKTYKLGLGLPLTGSAASYGEEYRAIVEMGIEKTNRDFAADGIKIELVTADTQATAEGGVNAANKLGAVEKAPAILTGWGTVVQASMPIAEDLGFALLNAGVQTSSLVGASPNLVNLLPMNNSMFADYASHLTKTLGYKKFAYVAIDTDTGRAAAGEFANAVKAQGGEIVATESIRQDATDATAQIAKIKAANPDFLYVHALLVDGASILKAAREADLKSVIGTYNAVAESKVIREAGQEKSNGMLYVSHLPKDVDGTRELLKSLQESHPKMVIANQSYDPYWYATPFLYAQVIKKLRAQGAPVTGGNVLAVLREAKDLNVPIIGPVDLTNKLTYKAPTTIRQIKDWKADPLEDETVASVSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E264</accession>
    <name>A0A1H6E264_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91005">
        <property type="protein sequence ID" value="SEG91005"/>
        <property type="gene ID" value="SAMN04489712_12812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="233"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG91005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="466" mass="52216" checksum="AEB50D438B60EF04" modified="2017-01-18" version="1">MNNITYDVRIYKTEVYRGKNVTTYTVRWKTGPKPWKQPFRNKAQADSFQAELRAAARKGEAFDITTGRPVAWGRAGKDVSWYAFCVSYVDMKWKGASAKHRANTAWALVTVMPAMLATERGKPVDKRVRSALRRWAFNTKNRGECPEDAAAVLKWVERSTKPVSALADPKVMRAVLDTAATRLDGKPAAPSTVQRNRAILHHACEYAVELGLLDSNPVKTTKWKAPKGSSEVDRRSVVNHRQARRLLEAVGAQEPSGPRLVAFFAVIYYAGLRPEEAVNLRRDNVILPLLVLNEETGQVEKPADGWGELRFCTAAPEVGAEWTDDGARREHRRLKGRGQGEWRRVPVPPPLTRILRRHLTDIGTGPGGRLFWGVRGGELPTITYRRAWDKARRTTLSEAEYASPLARRVYDLRHACVSTWLNGGVPAPQVAEWAGHSVEVLLRVYAKCIDGQDETAKRRIEAALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3G0</accession>
    <name>A0A1H6E3G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92170">
        <property type="protein sequence ID" value="SEG92170"/>
        <property type="gene ID" value="SAMN04489712_13245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="20991" checksum="BFBE2FEBE3AA5143" modified="2017-01-18" version="1">MSSTLLYLAIVAVWAVVLVPMWLRRDNDGFSRLLSKRSGSPEELDLEEDPALDDREPTAYDEPVEAPPTPPPPPRRRSSRAAVIARRRRRTFGLTLLLLASVTVVATGLAPWWAALPSVLLLAGHLSLLRVAAAMDTARRQAEAQARAAARRAAREAERPERPAKAEIIELVLPDEVFDQYADDRRAVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3W0</accession>
    <name>A0A1H6E3W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91933">
        <property type="protein sequence ID" value="SEG91933"/>
        <property type="gene ID" value="SAMN04489712_13134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="81" mass="8630" checksum="163A28BDF0665559" modified="2017-01-18" version="1">MSTGGDGELIIANEFASVVVRKVATRNGERLEIRSLGDDAHVIRLDALALQALTWSDPLTVGRGLETPLGPEKTAADKETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E558</accession>
    <name>A0A1H6E558_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92144">
        <property type="protein sequence ID" value="SEG92144"/>
        <property type="gene ID" value="SAMN04489712_13238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296561" evidence="1">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="35138" checksum="9E0178B5DB6AB9BC" modified="2017-01-18" version="1">MRSTVRRFVSVLGAVALLSTAACTNEEPGPQASGRPTVPGPPTTRLLYALSQVTATEENKRHVEFTDLAALRRVSNGRPFDRRFGLLAVGAGELAGFAERIAQPTGIDLSQATDALVTGSTSGDAGRINGPFDAKTIGAKLTGLGYTPVPGVPNAWAGASEDGLDADDPLVKLGVTASHGLNVVRVDSGEGITYARQRDALRRIPAERGSGSLADEPAHRAVAGCLGTAIAAVLLVDEPQPHPPNLVGVGVTSGASAGDLRQIMCVQVDGDAAAAVRTLQRTLREGSSRTGTAWQRLLPEATVEQAGDGMIRLTATPAASAGPGLLIRALIVNDLPRWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5A0</accession>
    <name>A0A1H6E5A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase, MSMEG_4879 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92938">
        <property type="protein sequence ID" value="SEG92938"/>
        <property type="gene ID" value="SAMN04489712_13620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="30877" checksum="0830A25E3E10B95A" modified="2017-01-18" version="1">MRIAVHSGVTMRGRVEGVVGEVRKVAEYGLAGYWAPMLTGHDTLTTFAIAGREVPGVELGTAVVPMPLRPPFALAQQVATVQEVLGGRLALGIGPSHEALVRDAFGLEWTPPIAATRRYVEQLQAVMTGRDGRGVAIGGDPTPILLGAVNPAMARLAAQVAAGVVTWAAGPRTITEVIRPALRDRPAEEPFRIVAALPVCVTDDVASAREHIHRRLGANDRFPSYQKVLRREGVDGVARLAIVGSPDEVARRLDAFADSGVTDFAAHPLAENDVDAERTWEFLAARAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7Q3</accession>
    <name>A0A1H6E7Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crotonobetaine/carnitine-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92976">
        <property type="protein sequence ID" value="SEG92976"/>
        <property type="gene ID" value="SAMN04489712_13634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="422"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="530" mass="56486" checksum="7D651F711128E3EB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9N2</accession>
    <name>A0A1H6E9N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_14214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93971">
        <property type="protein sequence ID" value="SEG93971"/>
        <property type="gene ID" value="SAMN04489712_14214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="138"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG93971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="35254" checksum="64ED4E97A9CB05C5" modified="2017-01-18" version="1">MTVQPTKAPGPRLPGFVRGWLPLLLGGALVGTALSTPMVLPVVRLALAVLGLAFAYAGAARLLRARFGPDFDPGLWLGVAWLVLIVLAAATADLLPLPESLDPSKALTEPTYAAPSAAHLLGTDQYGLDILGQIVHGARVSLIVGLGGVLIGGTIGTLLGLTASYLRGRVDGVVGWGTDVLLSFPPLVLLMALAAVLEPRTRNICLALGILVIPSFVRLSRAAGLKVAGQPFVLMARALGATRRRILFREILPNILPSVLSYALLVVAILIVAEASLSFLGLSIQRPQPTWGNMIAEAEAKFQTHPFLLAPAVPLFLTVYSINRIGDFLRAGKDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAJ1</accession>
    <name>A0A1H6EAJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94271">
        <property type="protein sequence ID" value="SEG94271"/>
        <property type="gene ID" value="SAMN04489712_1455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="105" mass="10630" checksum="9EE5DF01282924E7" modified="2017-01-18" version="1">MALGGAIAPYARAGAIVNADGSVIRSKGVTAVRKTATGRYCIELEAGIDASTALVVATPKWGANWDSIVLVNEGPVDCGDASRNVFVGTGRPSGAADEPFVVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECC3</accession>
    <name>A0A1H6ECC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94554">
        <property type="protein sequence ID" value="SEG94554"/>
        <property type="gene ID" value="SAMN04489712_14821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="28180" checksum="5CD3D5EC7FFDB750" modified="2017-01-18" version="1">MGTFAVTGSASGMGAATAAVLTDAGHTVIGVDLHDAEVIADLGTAEGRRTAIEAIVEISGGTLDGVAAIAGVGPNLPDAAAVLSINHFGPVTLLNGLRPALERSGAGRAVVIGSNSATTVPLIDDHLVELALAGDEDAAREHARAAQSAMPQEILDFAPSIAAYASSKFALARWVRRTAVTPEWARRGVLLNAIAPGAVLTPLMLGSTGNGADLNADEFPTPMPLGVFGRPEDIAFWVHQFLRPEARFTTGAVLYVDGGTDAAMRPDSQPTAMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECF9</accession>
    <name>A0A1H6ECF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_15015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94709">
        <property type="protein sequence ID" value="SEG94709"/>
        <property type="gene ID" value="SAMN04489712_15015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="184"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="447" mass="48549" checksum="FC66B36470CB97D0" modified="2017-01-18" version="1">MNDLLLVLAVSAAVVVAGLWAWRRYHPASFWYGVGYPSRMLLVYLTWAHVASGCGLSRKRRRWRLTLDAVPVAGPAARSVTVAQYKRRMRRVDIERAPRLGWLRPTRLGWRVRVRLHDGQVPADYEKAAEGIAHAWRVHSVRVVDVRPGKVTLWATMRDPLTEVSVVCETGELLTVRPGKLENGADWVIDFRTVPHWLNAGATQSGKSNLANAILKGLAPQPVALVGFDLKGGVEFTPYAPRLSALATTRAECVGLLADLVGEVEARMATCRAQGARNVWTLPEDLRPVPIVVLVDEVAELFLMADKSEKEEVAKTGTALLRVAQLGRAFAVHLIVCGQRIGSDLGPGVTALRSQLSGRVCHRVNDPETATMTLGDLDPAALDAARAIPAETPGVCVVAGQDGTWHRARSVYVPEHQAEQAARTFAHLAPAWADLIGGPPTVRPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5RZC5</accession>
    <name>A0A1H5RZC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-hairpin-helix motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43570">
        <property type="protein sequence ID" value="SEF43570"/>
        <property type="gene ID" value="SAMN04489712_10112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF43570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="24526" checksum="94FB1C0010CFA35C" modified="2017-01-18" version="1">MTPPVPYGPRVPSDGMSPGRAALSVTWAALPFLTLGWATPFVFAGAAIWRRTGHLMIASVIYLGLFALQTVLLPDIDTDPGAERLYGACLLTQTVVGCFHAFLVRRRVFDPEGTGGVAGNAAAIGLVRRQRLLRAKARELAATDPAMAKELRIGRPDLPRRYDDGGLIDVNHAPAGVLAMLPGITDELARRIEKVRGETGGFLSAEELSTLAALPPALTTDLAEYGVFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S563</accession>
    <name>A0A1H5S563_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YacP-like NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45742">
        <property type="protein sequence ID" value="SEF45742"/>
        <property type="gene ID" value="SAMN04489712_10185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="PTHR34547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF45742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="484" mass="52608" checksum="5E98A0F5CE25EE8B" modified="2017-01-18" version="1">MRTLVRLRSGGAWKAGESPAGAPYREPEPGRSTIIDSGPQTPKVPQAPAERLDGPLPEAVRQRVVEAAADLVGTLPMDEIPSSLRPFARWERRKRARHAGRHIAPVLEKDPGFRERVAGPLRNAEPELVEAVEAGVVPPAADPVGVAVIAYLLRPSGWPRLVEAARRELERSASAAEDEAYERRITALQQELAAARTGRAAELERLRAELREAKTEITELRRKLHEERAAAKAARQRAEVLAAETERERATAREVGAAADKELRRLRARLAQAEATAESARRAAREGRNVDDVRLRMLLDTLVDAAQGVRRELALPSMIERPADAVGSVDPERPGHRALPGRALSDQDPRLLDRLLTLPQVHLIIDGYNVTKTGYGELPLADQRSRLVNGLGGLAAQTGAEVTCVFDGAELDAPVAIAAPRGVRVRFSRPSQTADELIGELVRAEPPGRPVVVVSSDREVADAARRAEARPAPSTLLLRRLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SDI2</accession>
    <name>A0A1H5SDI2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ORF">SAMN04489712_101167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48686">
        <property type="protein sequence ID" value="SEF48686"/>
        <property type="gene ID" value="SAMN04489712_101167"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="187"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="192"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="308"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF48686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="41867" checksum="C72620D416E38426" modified="2017-01-18" version="1">MTPDKPRVVLGVSAGIAAYKVCELLRRLTESGHDVRVVPTRDALRFVGEPTWAALSGNPVATEVWTGVDEVPHVRLGQTADLVFVAPATADLLARAAHGLADDLLTNTLLTARCPVVFAPAMHTEMWEHPATRANVATLRERGAIVLEPASGRLTGADTGKGRLPEPAELFEAARRALARGGLPADLAGRHVVVSAGGTREPLDPVRFIGNRSSGLQGYALARTALARGARVTLVAANVALPDPAGAEVVAVGTAEEMHKAVLEAAGSADAVVMAAAVADFRPADYRESKIKKSESAGPAPIELVRNPDILAELGRRRRDGQVIVGFAAETDDVLANGRDKLARKGCDLLVVNQVGADLTFGRPDNAAVVLAADGGSTEVPRGPKEALADVVWDLVADRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJ87</accession>
    <name>A0A1H5SJ87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49871">
        <property type="protein sequence ID" value="SEF49871"/>
        <property type="gene ID" value="SAMN04489712_101206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF49871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="482" mass="49016" checksum="2A053B0EC7E03B4C" modified="2017-01-18" version="1">MNDPRRWLALGAVALATFMTYLDNNVVNVALPSIQRDLGLTISGLEWIVSGYILVFAGLLLVGGRLADVFGVRRALLAGLAVFTVSSLVAGLASGQEMLIAARAVQGVGAALLTPAALAVLPAMFPDPRERGLAIGIWGGVGALALAIGPFTGGLLSEHAHWGWIFLINVPIGAVTAALALAGVRGVPGGRGASWRRLDPAGLATSATALFALTFALIEGESRGWTSGVILGCFAVSALAAALFVVAERRTADPMIDLSLVRHRVFSGGLLAMGLWSFGIFGIYFFTALYLQGSLGFSPTEAGAAFVPMALVMAVVAPLSGRAAARFGAAATVAAGLALMAVAVGAISGVGAGDGYPDLLPWFLLYGLGAGLLLPLTDVVLGVLPADRAGVASGTLNVSREVFGLLGITVLGAILNSRQSGHLRDGLAPQDAFLEAYQSTLLVAAAIVAVGIPLSLYALRGARPAVTIVAGPAEAVPEPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SKH2</accession>
    <name>A0A1H5SKH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50940">
        <property type="protein sequence ID" value="SEF50940"/>
        <property type="gene ID" value="SAMN04489712_101246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="142"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF50940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="360" mass="37981" checksum="3FE7BC0F90F866F1" modified="2017-01-18" version="1">MADLHIERRKRLAGLVAETGAEAALITRLVNVRYLTGLASSNAALLIRADGTALLATDARYAGTAAAVCPDLETVIDRGTARVLTQRAAAAGARLLAFEAHDLTVERHAELLAAGGERLVTIPFGRRVESLRMVKDEQEIALLRRACAITDEAFEAVLPLIRPGVTEREIAVGLERRMVDLGADEPAFASIVAAGPNGAVPHHRPGDRPLAEGDLLTMDFGARCGGYHADMTRTVAVGRVAGWQRDLYELVAAAQRAGVAAACPGTETKAVDAAARAVIDGAGHGADFPHGLGHGVGLEIHEAPLMGYDKTGRLMDRVPITIEPGVYLTGRGGVRIEDTLVVRADGPEILTKTTKDLLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SM22</accession>
    <name>A0A1H5SM22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="8">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ileS</name>
        <name evidence="11" type="ORF">SAMN04489712_101274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51663">
        <property type="protein sequence ID" value="SEF51663"/>
        <property type="gene ID" value="SAMN04489712_101274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="692"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="597"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF51663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1059" mass="117979" checksum="672F8A74BA9EF952" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T7G6</accession>
    <name>A0A1H5T7G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58729">
        <property type="protein sequence ID" value="SEF58729"/>
        <property type="gene ID" value="SAMN04489712_101512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF58729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="24881" checksum="D9E4CCBDB4AAF71C" modified="2017-01-18" version="1">MVSDRAPRARGAETRELILDAAERLMAERGVHGVSLNEINTAAGQRNTAALHYHFGGRDGLLRAILRRHGGWLRARHDELYAEVTAGGRRPDVRGLVEVIVLPVAEYLGRGPSQRAAIRIWTSMLAQPALAVEDVRTLVDPSLTAAGRALVEIMARAMPRELAVERLVVASQSVMHVLADRAVLEDAPGSRRRPLPLSLVARNLVDMTVAALTAPVGAATREEAGQVIGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T9R3</accession>
    <name>A0A1H5T9R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted metal-dependent hydrolase, TIM-barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58821">
        <property type="protein sequence ID" value="SEF58821"/>
        <property type="gene ID" value="SAMN04489712_101515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="86"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF58821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="427" mass="47655" checksum="33134C826310162F" modified="2017-01-18" version="1">MNAEELIMISVDDHVVEPPGMFEAHIPERYRDQAPRVRTTKDGSDVWTFNGKTIPNIGLNAVAGRPKEEYGIEPTAFDEIRPGTYDIHERIKDMSAGGILASMNFPSFPGFSGRVFAATEDKDLALAVVRAYNDWHIDEWAGTYPGRIIPMALPVLWDAELCAEEVRRVAAKGCHSITFTENPATLGYPSFHNEYWDPLWRAVCDEDVVVSIHLGSSGQLSVTAPDAPIDVMITLQPMNVCQAAADLLWSRVIKKFPNIKFALSEGGTGWIPYFLDRLDRTYDMHHLWTGQDFGGKLPSEVFREHFLTCFISDPVGVQLRNLIGIDNIAWECDYPHSDSSWPNAPEELAEVAADVPDDDLNKITYQNAMRWYSFDPFVGGRTKDNGTVAALRAEVAGHDVSIRSYDKGRFQKQVGIEMGKLAEQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UVA5</accession>
    <name>A0A1H5UVA5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_10243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78910">
        <property type="protein sequence ID" value="SEF78910"/>
        <property type="gene ID" value="SAMN04489712_10243"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF78910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="174" mass="19152" checksum="C071C50400D4EF97" modified="2017-01-18" version="1">MSRHTLSVLVENKPGILARVAALFSRRGFNIDSLAVGTTEHPEISRMTIVVNVEELPLEQVTKQLNKLVNVLKIVELDTSSSVQRELVLIKVRADAETRSQVLETVQLFRAKVVDVAPDAVTVEATGNRDKLEALIRMLEPFGIKELVQSGMVAIGRGARSITDRSLRALDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UWI6</accession>
    <name>A0A1H5UWI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79366">
        <property type="protein sequence ID" value="SEF79366"/>
        <property type="gene ID" value="SAMN04489712_10261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF79366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="405" mass="40642" checksum="4DD7913F9713FFE5" modified="2017-01-18" version="1">MLFRARLGTFLTFALGGLLCGVWVARMPALTDKFGIGPGAAGMVLLVWGVAALAAMQGLRGVIARVGSRAVLRIAAPLAAATAALVALAPSYPLLLAAIAVFGMAFGVMDVAMNAQASVVERAHRRPLMSGMHAGWCVGAMTGGLIGALTAFAGLSFTQTLLGAALAALPAALALGRTYLADAPAAAAGPQAGERGRLPLAVYLIGALAFIAFMAEGAVADWSGLMLHDELHAAEWVAALGYPLFESAMLAGRLVGDRLRTRLGTRRLLVTAGAGTAAGATVVVCAPAVPMALAGFFLTGLMVCTIVPTMISLAGTTAPGRSSAAVAQVGAMGYGGLLLGPVIIGFLAEATSLRVGLGMIVVLALLIAVGARLLPIAADADLAAEYALAEARAQAEHKPALSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V2F5</accession>
    <name>A0A1H5V2F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81499">
        <property type="protein sequence ID" value="SEF81499"/>
        <property type="gene ID" value="SAMN04489712_102135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF81499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="33449" checksum="411B51A525F79B44" modified="2017-01-18" version="1">MRAMRIAVTGASGFVGGAVCRALAGRGVETFAYGRRAHTPSEHVGGAPYRSWDITTGLLSDAPEVDAVVHCAGSVTDWGPIEDFFRTNLDGTKNVLASFPTSRFVHVSTASVYDPYRPTVRAREPEAPVTRYLNGYGASKAAAERAVLAAMRERPAIILRPHAVYGPGDTTLLPRVLSAVRGPLLPAVGNGRQRISLTSIGNLVQACLLAATGPVGTGVFNITDAAPVVLDDALRQILAERGIRARPVYLPLKALWPLASAVEGAFLAARRPRPPRLTRYALSHLAVERTLDITAAREILGYAPAPTSLTGAATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VJI5</accession>
    <name>A0A1H5VJI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4253 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87469">
        <property type="protein sequence ID" value="SEF87469"/>
        <property type="gene ID" value="SAMN04489712_102347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025349">
        <property type="entry name" value="DUF4253"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14062">
        <property type="entry name" value="DUF4253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4253" evidence="2">
        <location>
            <begin position="167"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF87469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="29585" checksum="517C7AC289E1323F" modified="2017-01-18" version="1">MPDLHADPFDALPSGLPPGRLVVPDDDFTDGEWTGGAVLWVSDEPTPDAARHWLRLFEIRDKTGLYPLLLETLKGEPTRPWHDGELDVPAPVGSIDVLTAVGVLRRFWESVTEELPGDAGEDEQVDDSGVPRGPWPGLAPPGEPGRDPDAVAREYVQARYTGEKLLLGLVPAARGADTLARTGWQGPANHTGDVQEISAVVRSWEDRFGARVVAVGFATLDLSVAAPPATADQALGVAAEHHAFCPDNVWQNSDGFTEYAGRLIGAGNWSFWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VTA2</accession>
    <name>A0A1H5VTA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="3" type="ORF">SAMN04489712_102446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90363">
        <property type="protein sequence ID" value="SEF90363"/>
        <property type="gene ID" value="SAMN04489712_102446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF90363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="97" mass="11228" checksum="11D7BBEBE39A2B51" modified="2017-01-18" version="1">MTAPAPVELDRPRSQEDQRPDLPWLAIVWNDPINLMSYVTYVFQTVFGYPKTKAEKLMLDVHHKGRAVVASGTREEMERDVEILHSYGLWATVKRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VTC6</accession>
    <name>A0A1H5VTC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pregnancy-associated plasma protein-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90490">
        <property type="protein sequence ID" value="SEF90490"/>
        <property type="gene ID" value="SAMN04489712_102451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M43" evidence="2">
        <location>
            <begin position="248"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF90490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="37843" checksum="DB388C8B6FFF8446" modified="2017-01-18" version="1">MGTSGTRVVPPPEERPVAASLPAVPVRAAADRHCAPWAHAPRWSAARRTTAFTPGTGLFREDPYGLVPWPFGRDRATPDGEQVTEMLTALRQGLIRRYGTADEAAIERAARLTGRINVPVSFHVLTDGRRGRMSREAVRRQIAVLNAAYSGRGRGSADTGVRFRLVSYDVTVNAAWFRRPHRYERPMKSALRRGGAETLNLYSAGVGARIIGLSTYPHNYRARPIEDGVVVDYRSFPGGVYRNYSRGYTAVHEVGHWLGLFHTFENGCNSPGDGVDDTPYQAVPTDGCPESKDTCPEEPGADPVHNFMDYTWDTCMHQFTPGQGRRIRASWLVFRTSAADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W2Z3</accession>
    <name>A0A1H5W2Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe-S cluster assembly iron-binding protein IscA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93688">
        <property type="protein sequence ID" value="SEF93688"/>
        <property type="gene ID" value="SAMN04489712_102565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF93688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="9984" checksum="506128191DA1FD1B" modified="2017-01-18" version="1">MLTLTSGAVQVIRTVTANPELPPETGIRIASGVNGSQTLSLSVAPAPEAGDEIVEEEGARVYLEPGAAELLQDKTLDAQVDPQGDVAFTIGDSPGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WZ93</accession>
    <name>A0A1H5WZ93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04989">
        <property type="protein sequence ID" value="SEG04989"/>
        <property type="gene ID" value="SAMN04489712_10329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018988">
        <property type="entry name" value="DUF2000"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017021">
        <property type="entry name" value="UCP033763"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09391">
        <property type="entry name" value="DUF2000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033736">
        <property type="entry name" value="UCP033763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG04989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="157" mass="16701" checksum="FD81A27358A985C7" modified="2017-01-18" version="1">MTVSVPTWLGSLEQRPDLPTRELPVKWVIVADRELPRGLQVNAAACLAAAVGKAAPDLVGDGGADASGTPHTGLPWTGCTVLAATAPIVRTLRATAIAEPDLLVADMASIAQRVRVYSDYLDRLARTEDEDLAYYAVSIAGPRALVDRLTGRFPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X1T9</accession>
    <name>A0A1H5X1T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-methylacyl-CoA racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05206">
        <property type="protein sequence ID" value="SEG05206"/>
        <property type="gene ID" value="SAMN04489712_10336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG05206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="402" mass="42675" checksum="4BD14713678429D5" modified="2017-01-18" version="1">MSASKQGPLKGVRVIELAGIGPGPFAAMLLADLGAEVIRVDRPSAVLPPESRDIGKAMGPGGSDTALDPRSTDFSNRGKRSIAVDLKSERGRQVVLRLVEQADVLLEGFRPGVTERLGLGPDDCAAVNPRLVYGRMTGWGQQGRLAHSAGHDIGYIATTGTLHAIGRAGGPPQVPMNLLGDFAGGSMYLVVGVLAALLEAKVSGQGQVVDAAIVDGTAHLSTFIHGFLAGGLWTDQRGVNMLDTGAPWYDVYETADGRHVAVGAIEPQFYAEFIRLLGIKDADDLPSQHDRSGWPVLRERFAEAFRTRTRDEWAEIFLPGDACVAPVLSLKEAAEHPYNTEREVFVEEGGHLQPAPAPRLSRTPGAIAGPPALPGEHTREVLERLGFTDVDELLAEGAVAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X360</accession>
    <name>A0A1H5X360_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIM zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05767">
        <property type="protein sequence ID" value="SEG05767"/>
        <property type="gene ID" value="SAMN04489712_10356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG05767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="442" mass="48491" checksum="FF6DF44326BA963B" modified="2017-01-18" version="1">MNDRWGREQILGLAPDASSAKAAGGVAKPAKWRGAGCDSHSVWGECQGSGKSTYQACVDLSEPAFRCSCPSRKFPCKHALGLLLLWSEGAVDAAARPQWVAEWLDQRRQRAAKAEERRTATAARAPDPRTAERRAQRVDDGVAELARWLRDQVGQGLARAEQAPYRVWDDAARRLVDAQAPGLAAQVKSLSALRHGDGWPERLLEEYALLALLARAYRRRADLPEPLRATVRSRIGFTVPQEEVLRGERVRDEWYVAGSRDLAQDQITTRRAWLRGIRTGRSALVLSFAAPGRPLDASLVVGTAFDAELAFYPGAQPLRALVAERHGPVSAAPRGTTVGGLLQEYADALARDPWLDRWPAVLEGVRLATPRQTPVRADTLHAVDEHGDALPLHFSPSNESRHDPWRLLAVSGGGSFTLCGEWSPRGLRPLSAWHEQEGVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X5C1</accession>
    <name>A0A1H5X5C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06590">
        <property type="protein sequence ID" value="SEG06590"/>
        <property type="gene ID" value="SAMN04489712_10382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="566"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG06590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112087" checksum="5C158CFA6F330039" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XA12</accession>
    <name>A0A1H5XA12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08579">
        <property type="protein sequence ID" value="SEG08579"/>
        <property type="gene ID" value="SAMN04489712_103160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG08579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="23935" checksum="A08EA77A6DD0211E" modified="2017-01-18" version="1">MLSVTNLTAGYRRDHDVLTRISITLTPGRIVGVQGPSGCGKSTLIRVLALLHPPRSGDLRLDGETVRRFRYAAPAAQRRRVGVVFQHPRAAADPRHTLRRIVSAHLPAGAPGTETDRLAELVGLTPDLLDRRPHEVSDGQLQRACLARTLGADPRYLLCDEMTAMLDASSAAALVHLIKAQVEHHGRGALMVSHDSALLDACCDETVQWHDLGGPPAAPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XAQ4</accession>
    <name>A0A1H5XAQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08844">
        <property type="protein sequence ID" value="SEG08844"/>
        <property type="gene ID" value="SAMN04489712_103170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="37"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="123"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG08844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="34920" checksum="0936FD102DE5FCF5" modified="2017-01-18" version="1">MNHEIPLRRALLVSLLTLVIVAVGGYALVARPFRAEGTRLTAEFGRAGQGLGDGAPVKIRGVTVGSVERAELTGAGRARLTLRLDPGVRVPTSATASIEPASAFGPKFVDLVPGAGERGGPYLASGATIARTSDPQDLSDLLSDADATLRAVDATEVATIVRTLAQGLNGQGGRLRATIDHTSTLMDVAYRRRSEARRFLHDAAGLTGALAGAGSGDDLITISGDANTLIAGTAAGGRDRLGQFADQLSEISALVSHGFDKRGGQLGQGFRSGERAAALVYAQLGLAGNAVRTANGLLPLYGELTSMPGPEGKNYMRAQGLLPTDPCQLIIGLCGSTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XLK3</accession>
    <name>A0A1H5XLK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12493">
        <property type="protein sequence ID" value="SEG12493"/>
        <property type="gene ID" value="SAMN04489712_103305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG12493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="452" mass="49564" checksum="63080FDCE4CE1F2B" modified="2017-01-18" version="1">MARRPQTPGAPHILIVGGGYVGMYTALRLEKKLRRELKRGEVKITVVDPQSYMTYQPFLPEAAAGNLSPRHVVAPLRRVLPRCNVLNARVTELNHDQRWAIVQPVAGPPERISYDYLVMAAGSVSRTLPIPGLAEHGIGFKTIGEAIHLRNHVLAQLDIAESTKDAEIRRKALTFVFVGGGFAGVEALAELEDMARSAVKYYRNVSVEDLRWVLVEASDRILPEVGPEMGKWTAEQLRGRGIDVKMKTFLQSAVGGEVELSDGSRFPAGTLVWTAGVKAAPVVRNSDLPLDERGRVKATEYLTVEGVVRAYTAGDNAAVPDLTTEGQFCAPNAQHAVRQSKVLADNIVRSLRGKTLKPYVHNSVGSVAGLGLYKGVAHVYGIKVKGLAAWFLHRTYHVSRVPTLNRKVRVLADWTLALVFKRETVSLGSIEQPRAEFELASRDEAKPRSHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XRU9</accession>
    <name>A0A1H5XRU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14509">
        <property type="protein sequence ID" value="SEG14509"/>
        <property type="gene ID" value="SAMN04489712_103383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG14509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="84" mass="9558" checksum="CD2A1F79966FD4AB" modified="2017-01-18" version="1">MESQSPPLTRDCPLVCLTPSRRIINPLRHYLKGEGVHEPTVGDVLWLWQDDKLQDVRNLGPDAIKQIFTILMAAGLIHRHHNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XSC0</accession>
    <name>A0A1H5XSC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14156">
        <property type="protein sequence ID" value="SEG14156"/>
        <property type="gene ID" value="SAMN04489712_103369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="6"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="142"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG14156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="25785" checksum="D11B8417646D60D1" modified="2017-01-18" version="1">MNRTDRLYAIVEELRASAPRRRTARELARRYEVSVRTIERDIAALQQAGVPIYADVGRRGGYTIDKAMTLPPLNFTPAEAVAVAVALGRFEGAPFAEASRSALAKIVGAMPERDAAAARELAGRVRLMRRADAEPARIPPPIEQAVLARRVLRIRYEDRDGVTTEREVEPIVVTGGPFGWYLIGWCRLREDTRVFRLDRIRHAVLTGLPAPARRYEDSVSDLPGHLALVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YJR9</accession>
    <name>A0A1H5YJR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type I restriction enzyme, S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24234">
        <property type="protein sequence ID" value="SEG24234"/>
        <property type="gene ID" value="SAMN04489712_10448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG24234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="447" mass="49620" checksum="C236E53A7963A8BF" modified="2017-01-18" version="1">MTNLPSGWIRLPLCELGTWYGGGTPSKSNPEFWDDGTVPWLSPKDMNADVISGTRDHITEVAVQNSPVRVVPENSVAVVVRSGILERKVPIGLVSFAVTLNQDMKAISPGPWLDARWLSWGLRSLEKYILRNCRKSGTTVASIETKRLMDLKFPVPPLAEQRRIVAALEDHLSHLDAATAGCSTAGARIPLLRRSALQALRQRALQCKAELLPLGTIATTSLGKMLDSKRNEGEPTPYLRNINVRWGSFDLANIETVPMPEEQRTKFSLREGDLLVCEGGEPGRCAIWPGGYELMTYQKALHRIRPGDRITSEWLALMIEESIRNGRAVGMFTGTTIKHLPQEKLRMLNIPVPSREVQEDLLADFAETAQTVERFSNALATSEHKSEHLRRALLAEAFAGRLVEQDPADEPASVLLERIRAERAAGQPVRRARRGKGEKAPQKETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YNH0</accession>
    <name>A0A1H5YNH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24906">
        <property type="protein sequence ID" value="SEG24906"/>
        <property type="gene ID" value="SAMN04489712_10477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG24906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="63" mass="7065" checksum="ADCBA8739EE83712" modified="2017-01-18" version="1">MPDLGPFHAVSWEPIYAGKPVTRQGRPLIPDGKRRVVREQEEASRRIADGSLKNVPLVDGTWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YTA1</accession>
    <name>A0A1H5YTA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26942">
        <property type="protein sequence ID" value="SEG26942"/>
        <property type="gene ID" value="SAMN04489712_104156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290898" evidence="1">
        <location>
            <begin position="20"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="30880" checksum="FFFA1FCB79CE06C0" modified="2017-01-18" version="1">MRRLLPLTVWLCSDTSATAKTSGQSHGGGSAEGEYCPLHRRTVGHQLARHLITACTREGDLVAEAYTTSEATLAAAAGLGRRAVACVPDFPLARRIRARLDAALPHEVAALAAMRPCRPDQMARGLADHLGQVELVIAAPPPYRHDGQTRRASAGDHRCPVCRTGFWMNSQERFRSFMAAAWQVLRPGGRLAVITTARHEHGRLVDAAPRIIREAAGLRFRYVQHIIAVRVPVEGDTLVVQAEPRGLAELRDVRSRALPPVAKVHADVCLFTKPFPVGRDGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YTL8</accession>
    <name>A0A1H5YTL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase III subunit delta'</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_104166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27170">
        <property type="protein sequence ID" value="SEG27170"/>
        <property type="gene ID" value="SAMN04489712_104166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015199">
        <property type="entry name" value="DNA_pol_III_delta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09115">
        <property type="entry name" value="DNApol3-delta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="38"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG27170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="390" mass="41231" checksum="72DB14220492A30A" modified="2017-01-18" version="1">MSVWDDLVGQGPVVEQLATAAEAGAGALAGDERAAAGMTHAWLFTGPPGSGRSTAARAFAAALQCREAPRGCGHCASCHQALQGTHADIEVVRPTGLSYGVKETRELVLRAASSPSGGRWQVVLFEDADRATEAAANALLKAIEEPPPRTVWLLCSPSPEDLVTTIRSRCRLVTLRTPPASAVADVLIRRDGIDPETAEAAARAAQGDIGRARRLATDQETRRRRGEMLALPGRLTGVAPAVNAAAALVAAAEADAKATTEELNATETAELRRALGESEKGRMPRGTAGALKELEDRQKSRATRVKRDSLDRALLDLASYYRDVLALQLGSAVDLVNTDRAAELRSVASAGTPEETLRRLEAIMECRGRLDANVNPLLAVEAMTLALRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXK2</accession>
    <name>A0A1H5YXK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_104211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28177">
        <property type="protein sequence ID" value="SEG28177"/>
        <property type="gene ID" value="SAMN04489712_104211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="719"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="17"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="291"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="492"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="751"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG28177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="847" mass="87349" checksum="060F939697E43B7C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z3Q6</accession>
    <name>A0A1H5Z3Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31209">
        <property type="protein sequence ID" value="SEG31209"/>
        <property type="gene ID" value="SAMN04489712_104345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG31209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="124" mass="12977" checksum="1CC4C2BA22E55DEC" modified="2017-01-18" version="1">MARAVDPDGSAMQQDGGNLISRHLNAAFGSRRLHLAALDAAIVADPHGLACGVVSGEGSTPVLKIIREDRPGLSVDVGCDRVAGRWWFLVEPGGEGVTPVDEVERAPEVLARILGRDGASDANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z751</accession>
    <name>A0A1H5Z751_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid/cholesterol/gamma-HCH transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31974">
        <property type="protein sequence ID" value="SEG31974"/>
        <property type="gene ID" value="SAMN04489712_104387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG31974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="30114" checksum="94EE65572A10FDEC" modified="2017-01-18" version="1">MAAPPKGGRAVAKAVNAPLERVEDFGHQLSFYARAFAWVFRVLRRYRTEVLRLLAEVSLGTGGLAVIGGSVAIVGFMTFFTGSQVGLQGYNSLNQIGTAAYTGFVSSYFNTRELAPLVSALALSATVGCGFTAQLGAMRISDEIDALEVMAVPTVPFLVTTRLLAGMIAVIPLYVVGLLASYLATRLIVTTFYEQSTGTYDHYFNLFLPPYDILWSFGKVIVFAILVMLIHCYYGFHASGGPAGVGVAVGRAVRTSIVVINLADLFLGMAIWGATTSVRIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZDN8</accession>
    <name>A0A1H5ZDN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34180">
        <property type="protein sequence ID" value="SEG34180"/>
        <property type="gene ID" value="SAMN04489712_104487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291438" evidence="1">
        <location>
            <begin position="25"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="154" mass="16881" checksum="7D017FBC9A1C6C6D" modified="2017-01-18" version="1">MRRIPTRLVVPATIALLGLTAAPAAGGQAAGPAQRAAAGSEAYFEFDYPPGPERFIFRLTDPDKIREARDILSGSERHKTHVLGKIVKSTAPYNPGWNYHLDPQSISFFAYAIEVCDATPWYVQNHLDEVGGAFLPGAHWCPWGSRLLREVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZIW7</accession>
    <name>A0A1H5ZIW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoside ABC transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_104552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35597">
        <property type="protein sequence ID" value="SEG35597"/>
        <property type="gene ID" value="SAMN04489712_104552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG35597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="425" mass="43282" checksum="DE8DEFB1EFB99E3D" modified="2017-01-18" version="1">MSEQATPAREAAAEPAAGGGEPPEADRFRRLVAQTVAGPPWVVTVLAIALALVVGGLLMIISDPEVTDTFGYFFARPADALSASWSEVSTAYAALFKGAIFNPDAAGSLTEALRPISETLTEATPLIFGGLAVGLAFRAGLFNIGGQGQLIMGAIATTWVGFTLDAPGFVALPAAVLAGLAGGALYGALVGWLKAGPGAHEVIVTIMLNYVAFLLLGYLIGSDVFRDPDNPQPISKPVADAARLPHLFGDSLRVNAGLLLAIAAVVFTWWLLNRSTLGFQLRAVGANPSAARTAGMSVGYGQIMAMTLSGGLMGLVGMSQVLGTANANNALTQQIDAGLGFTAITVALLGRASPVGTVAAALLFGALQAGGREMQAAAGVSIEIVTVIQALIVLFVAAPPLVRGIFRLRGEGGGHSGLLAKGWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A152</accession>
    <name>A0A1H6A152_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase, sigma 29 subunit, SigE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42082">
        <property type="protein sequence ID" value="SEG42082"/>
        <property type="gene ID" value="SAMN04489712_105116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG42082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="22591" checksum="2AA425EBA7E7EA0B" modified="2017-01-18" version="1">MNVAALALKGGAAALDREHVPEARWEPPSWDEVVREHSARVYRLAYRLTGNPHDAEDLTQEVFVRVFRSLSNYTPGTFEGWLHRITTNLFLDMARRKQRIRFEGLADDAADRLQGREPTPAQAYDDRNLDADVQAALDALAPEYRAAVVLCDIEGLSYEEIAATLGVKLGTVRSRIHRGRAQLRAALEHRAPRRLAAPEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2M8</accession>
    <name>A0A1H6A2M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_105173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43013">
        <property type="protein sequence ID" value="SEG43013"/>
        <property type="gene ID" value="SAMN04489712_105173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="4"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="299"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG43013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="536" mass="55842" checksum="4E3C6BD2193AC899" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A601</accession>
    <name>A0A1H6A601_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43457">
        <property type="protein sequence ID" value="SEG43457"/>
        <property type="gene ID" value="SAMN04489712_105197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG43457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="189" mass="20315" checksum="3B98C5D43DFBFEAD" modified="2017-01-18" version="1">MIAAVLAAVLAAAGCADGDADTPPTPAGFVRYDGPVYSFAHPADWTRKPRRNVRGEPEIWLVGPPTASGAPQGEVLVGGQSEARPYGSQAQRRRFELQLGEYRAASLLTERRIRMDRSTKVPGAEVAHRFEAVGEMSTNPGRSVRMEVIDLYALTEDGVMVNIAVRAPEGGGEAAGLPEVLESFRIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A603</accession>
    <name>A0A1H6A603_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_105237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44173">
        <property type="protein sequence ID" value="SEG44173"/>
        <property type="gene ID" value="SAMN04489712_105237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="210"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG44173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="447" mass="49696" checksum="D3AEC12A5954FA50" modified="2017-01-18" version="1">MAVYDRWHLSHPPEGAEPCKCGRGRNKLYPSADHGTARRWQVRWRDESGRQRKKNFTEKVGDDPERHAAACDAKVNAELDADSWIDPELGKITLEAYAKQWRGGLASDPASLETVDKHLAHIYDVERTDRTKRAPGSSPIGHREMRALAKSPSAIQQWVKSLEAKGLAPGYVKAITTTLSTIFAAAIEDGRISRNPVRSKSVRLPTVPDRKVRPWTLEMVQAARAEVDRRHSSGAMVDLAAAAGLRESEVFAFAEEDIVFLGADRKILVRRQIKRIKDAEGRYQLVFALPKRGKEREVPLSDTLSLRLSEQMAKRPPVPVTLPWGRPDGKPRTFRLLFVKADGLPWYRQAFEHTWTAARAAAGAPPPPDENGRFHGLRHTFASIQLAGGADILKLAAWLGHTDPGFTLRTYAHLMPDVRDVGRRAVDDFFGAADRPSALDVPSKSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AHU8</accession>
    <name>A0A1H6AHU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48091">
        <property type="protein sequence ID" value="SEG48091"/>
        <property type="gene ID" value="SAMN04489712_105456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="217"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG48091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="324" mass="35113" checksum="7090434AFBC59808" modified="2017-01-18" version="1">MTHTIPDMGTVALAVTDGMLHFELSQAYEVFASAPAGVTVPWYDVTVCGPVAVRVGRFHLEPDLGLDRLQHADTVIVPGWADIDEEPPAGLVDAVRAAHEAGARVASLCTGAFVLAAAGLLDGKRATTHWAHTDVLAARYPRVEVDPDVLYVDNGSVLTSAGKAAAMDLCLHLVRLDHGSSIANAVARRLVVPPHRAGGQAQFVTTPVPAQDDHPLAALFPWILERLDQPLTVEDLARQARMSSRHLGRHFKSVTGTTPLQWLLTQRIRHAQELLETTDDSIDTIAAATGMGTATTLRRHFNRTIGVPPDTYRRTFREEHPKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AVR2</accession>
    <name>A0A1H6AVR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52167">
        <property type="protein sequence ID" value="SEG52167"/>
        <property type="gene ID" value="SAMN04489712_10611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="25333" checksum="91DAEC1F055753D6" modified="2017-01-18" version="1">MPPRVLGVIIGSDHERERTVDFTGEFETHLTVRCGERRLEALARWAAAHGHGFAHIVLDRGRVVSQPMLTLRGTGTLAEVMAAAGRTAAALRADGFEVTRSKVEAAPWNRGVPADDAEAAELGPGRYFEHHLKLLLEPGFDAAALTALVAPHAARLSRNARRVRADGVAERFVTQRCRLVGAPAAERRLAALVAALRERHHRIAEVEREFVVFDGDESLDDGWIDEREMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5V9</accession>
    <name>A0A1H6B5V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56012">
        <property type="protein sequence ID" value="SEG56012"/>
        <property type="gene ID" value="SAMN04489712_106277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG56012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="9671" checksum="EA65A820E0283694" modified="2017-01-18" version="1">MAVVGAREMADARRHHLAALAYEIEARGLSWRLAGPGESVLHVANPVTRRQVMVVAMPTGDGWFYLWAGGGMGDVTQPARAADQIARMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B9E8</accession>
    <name>A0A1H6B9E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56796">
        <property type="protein sequence ID" value="SEG56796"/>
        <property type="gene ID" value="SAMN04489712_106337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="24383" checksum="C8C0C573033B8736" modified="2017-01-18" version="1">MADAWLPGAGRIPAELDGGQLKGGAPRVVWFTSEHDPRSVSARSAAHDLARTGRPAHLVWNPHTGEIVQLLPATRAACLLADPVRGEGRVCLQILVIGLAREPFTGGPLNGLDAIMRWLDGWGVPRRWPAGPPLPSPQSYHSDRQRRPWARGGHFGASQVPECVLPDPGGLDIHRITGQDTPAVEIPRPRPPAGQRTTPATPAASGAPPQVLPHRLARTAEPLLTPGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKW5</accession>
    <name>A0A1H6BKW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase Lhr and Lhr-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61272">
        <property type="protein sequence ID" value="SEG61272"/>
        <property type="gene ID" value="SAMN04489712_107199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="277"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG61272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1612" mass="173182" checksum="CD26EEB0C533110D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLE4</accession>
    <name>A0A1H6BLE4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ORF">SAMN04489712_107218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61494">
        <property type="protein sequence ID" value="SEG61494"/>
        <property type="gene ID" value="SAMN04489712_107218"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG61494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="30014" checksum="4EE461CBD671A566" modified="2017-01-18" version="1">MVTPMAADGAVDYDGAARLAAYLVDEQRNDGLVVSGTTGESPTTSDEEKDRLLRAVIEAVGDRATVVAGVGTNDTAHTVELARHAERAGAHGLLVVTPYYNKPPQEGLLAHFTAVADATGLPNMLYDIPGRAGVAIHTETLLRLAEHPRITAVKDAKGDLFAGSQVMAGGGLAFYSGDDNLNLPWLSVGAAGFVSVIGHVAGADLHEMIEAYRAGDTGRALAIHRRLLPVVAAIMTRTQGAIAVKAALGLLGQPGGPLRPPLVPATPEFTAQLREDLAQGGIKVPEVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLI8</accession>
    <name>A0A1H6BLI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="6">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="6">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">menA</name>
        <name evidence="7" type="ORF">SAMN04489712_107226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61589">
        <property type="protein sequence ID" value="SEG61589"/>
        <property type="gene ID" value="SAMN04489712_107226"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG61589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="29607" checksum="9E6E472A6F420CC0" modified="2017-01-18" version="1">MATLAQWIAGSRPRTLPASLVPVIAGTGVAVGAGHAVWWRAGLAGIVALALQVGVNYSNDYSDGIRGTDDARVGPLRLVGSGAARPRSVLAAALGCFLVAAVAGLVLAAVTTWWLLLVGAAAIVAAWFYTGGKNPYGYRALGEVSVFVFFGLVAVVGTVYVQLERVPWEAWAAAVPIGLLACALLVANNLRDVPTDTESGKRTLAVLLGGPRTRILYAACTALPFPIALAMAAPRPWVLLALLATPLSLPPTQKVMQGAKGAALIPVLGETGRLQVAYGTLLAVGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLV6</accession>
    <name>A0A1H6BLV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Predicted Zn-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_107234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61680">
        <property type="protein sequence ID" value="SEG61680"/>
        <property type="gene ID" value="SAMN04489712_107234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="36"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="190"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG61680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="441" mass="47449" checksum="27717A55DC6B6D28" modified="2017-01-18" version="1">MTLSARAQEPGTTHTIHPGVDGAGAVRRTVLPGGLRVITETMPTVRSAAFGIWAGVGSRDEAAQDAGASHYLEHTLFKGTRRRSALEISAALDAVGGDLNAFTAKEYTCYYARVLDTDLPLAVDVVSDMVIGSLNRAEDVEAERGVILEEIAMRDDDPGDLVHDEFALALYGDVPLGRPILGTVETINALSRDVIDRYYREHYLTPNLVVAVAGNIDHDDVVRRVAEAFAGRPAGDDRPAPPRLGGGPAPVRPGVRVIDKDTEQANLVLGGLGVSRTDERRFALGVLNAALGGGMSSRLFQEVREKRGLAYSVYSYTAQYADTGTFGVYAGCQPGKVDEVLSICRDEVARLADGGLDEEELERGKGQLRGSMVLGLEDTGSRMSRLGKSELVYERLMPVDEVLARVEAVTLDDVREVGRQVLAQLDTLTVIGPFGDRDFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLV9</accession>
    <name>A0A1H6BLV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_107191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61176">
        <property type="protein sequence ID" value="SEG61176"/>
        <property type="gene ID" value="SAMN04489712_107191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="71"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG61176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="329" mass="35069" checksum="2737ADED00F098A4" modified="2017-01-18" version="1">MSRQEATVLFDAPGPRARLRHNILTAVAVVVLLALAYVVYARLDERGQWAGELWEPFVDWQVWENLILPGLKNTLGAAAVASVLALLFGVVFGLARLSDHWWIRVPAGAVVEFFRAMPLLILIFLAFFVPPAVSPIIADGPFGNAQRVLVDNVLFVFGVEINAGNVTVPAFAALVFGLVMYNGSVLAEVVRAGVLAVPRGQSEAAYAIGLRKNAVMRLVLLPQAITAMMPAVVSQLVVLLKDTALGFIIAYADLLSAGFRIVPANYHNLVPAAIVVSVIYIGMNMALSRLATWLEGRTRRSPKTSAATLGVGTGTPAATGMSQVGTGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BW75</accession>
    <name>A0A1H6BW75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64951">
        <property type="protein sequence ID" value="SEG64951"/>
        <property type="gene ID" value="SAMN04489712_10866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="200"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG64951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="369" mass="39565" checksum="6ED918CB2E891CEF" modified="2017-01-18" version="1">MPLLRIRTQIEDRPGRLAVLTAALAERGANILGLSVQVDAEGVVDEFVVDVRRGGAWPRELAAAIEAAGGRHTTVVPARPHELIDEPTRALTLAARLRTDPRSLPRALAELLRADSAAWVSGAAALREPGPDGRHDADAPRSFELLVPVGPLRAVRLRRAGLPFTATEAARADALVRAALPADEPRPTSRRVLLRDGTEIVVRPLERRDGAAVQAMHERCSQASRRARYFSAKPSLPQRALDLFCEPAYGLTLVAEGPDGSILALAHLVHVLDPGVAEPAFLVEDAWQGRGLGRMLTDLLLVLGRDRGLVELRASVLADNARMRRLLTGVGGRIRHTDDPAVVEIRVRLDGRAARAAAASPGARVPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C049</accession>
    <name>A0A1H6C049_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoenolpyruvate phosphomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66117">
        <property type="protein sequence ID" value="SEG66117"/>
        <property type="gene ID" value="SAMN04489712_108165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG66117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="32518" checksum="6D65D941680DD547" modified="2017-01-18" version="1">MNTSLHAVLPGRPAEERRAALRALLASGRAFVAPGVTDAAGIRLVEEAGFGCAYLTGAGLANAQYGLPDIGLLSQREVVDHVRRLADATDLPLIVDADTGYGGSLSVMRTVRQLIDAGAAAVQLEDQVLNKRCGHFDEHQLVSAEEMAGKIEAAVAARGDSRLVLIARTDARGVLGLDEAIARARAYAAAGADVIFVEAPRTVEEMRVIATELAGVPLLANIVEGGKTPELSLAELEELGFTVALFANYLMRSMLHAGRAALAHLARAGETRSRADALLPWADRQRLFSLAGYTELEQRFTAGREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2E4</accession>
    <name>A0A1H6C2E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-lactate dehydrogenase (Cytochrome)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_108261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1H6C2E4"/>
    <dbReference type="EnsemblBacteria" id="SEG67180">
        <property type="protein sequence ID" value="SEG67180"/>
        <property type="gene ID" value="SAMN04489712_108261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023989">
        <property type="entry name" value="MftD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03966">
        <property type="entry name" value="actino_HemFlav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="310"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="333"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG67180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="42465" checksum="1CC4D24FE3485559" modified="2017-01-18" version="1">MSGAWFETVTEAQRRARKRLPKSVYGALLAGSERGVSYDDNTKAFAELGFAPHVAGLSAKRDLGTTVMGESISLPVIISPTGVQAVHPDGEVAVARAAAARGTAMGLSSFASKPLTEVVAANPQVFFQMYWMGSKDAMLRRIEHARAAGAKGLIVTLDWSFSHGRDWGSPWIPERLDFKAMAKLAPQALARPRWLLEYVKTRRLPDLTTPNLAEAGQEAPTFFGAYGEWMQTPPPSWEDVRWLREQWGDAPFMLKGVCRVDDALRAVDAGVTAISVSNHGGNNLDGTPAPIRALPAVAQAVGDQVEVLLDGGVRRGGDVVKALALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGMDSALLGLGRSSIHELTPDDVLVPAGFTRDLGVVEQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C307</accession>
    <name>A0A1H6C307_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_108274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67302">
        <property type="protein sequence ID" value="SEG67302"/>
        <property type="gene ID" value="SAMN04489712_108274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="203"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG67302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="35891" checksum="2F74E9AE9B3807D2" modified="2017-01-18" version="1">MNLDFTDDQEALRGAVREFFDKESPPEVVRAAEPLGFDAALWRKVVELGLPAIAVPEDRGGGGAGFVELAIAAEFLGRSLAPVPLIEAAVATTLLTSVPGEATPAADAVAGELLATVALHPVTGDVARLVPAGAVADLVVVLRGEELLAVRGPGGPAGAAGAVPNLGAMPVADRRLDTGEVTVLAKGAQAVAAHRRAVRHWELLTGAALLGIASRALELGIDYVLDRRAFGVPIAGFQTVQHRLADNSTAIEGTRLLAYKAAWAHDAGLPSAGTLATMSLLFASETAFKTASDSLHFHGGYGYTLEYDVQLYFRRAKAWPLVAGDRRVAYARLPHRLFDATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CD91</accession>
    <name>A0A1H6CD91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_109224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70951">
        <property type="protein sequence ID" value="SEG70951"/>
        <property type="gene ID" value="SAMN04489712_109224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG70951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="162" mass="17888" checksum="41AE6DB8033C0C03" modified="2017-01-18" version="1">MDRVLALDGKGNALTAFLPVMRVPGVPDDAPMPAALAVVWCGRHLLLVFDRFRRQWELPGGRIDPGETPRQAAVRELHEESGLHLPALTLAGYARFRLTGPPRDEYAAIYTAHVATRHDDFTPNQEISAVHWWDTDAPPPDGSQIIDTTLALLTRLGRQPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDE4</accession>
    <name>A0A1H6CDE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YxjI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70882">
        <property type="protein sequence ID" value="SEG70882"/>
        <property type="gene ID" value="SAMN04489712_109216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="SSF54518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="202" mass="23093" checksum="04D11C2A8B616DA8" modified="2017-01-18" version="1">MSGMNVDRLQACTRFLVRQRIRFMVNQYEVHTEAQGGSEGELVAFAQQKRLAFKEEVTLYSDTDKKNPFLRFKARKRIDLGATYDVTDAAGQPIGTFKKDFAKSLLSSTWHLEQPGLGVTTGSERSRAVALLRRGWEFIPFVSNLPFAWPYHFDFVAGDQVVFSVDKKFGLRDRYVVDIRDPRLDRRLVIAQAIALDALQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDN9</accession>
    <name>A0A1H6CDN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_109200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70755">
        <property type="protein sequence ID" value="SEG70755"/>
        <property type="gene ID" value="SAMN04489712_109200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG70755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="772" mass="79559" checksum="1CE33A3CF30A5D45" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLH4</accession>
    <name>A0A1H6CLH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73607">
        <property type="protein sequence ID" value="SEG73607"/>
        <property type="gene ID" value="SAMN04489712_110131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294976" evidence="2">
        <location>
            <begin position="43"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="223" mass="22853" checksum="59133915E562530B" modified="2017-01-18" version="1">MTALQTPAAVPVALPASSSKRRLLTCAVVAAPLWTVVSLAQAATREGFDLTRHPLSMLSNGSLGWLQIANFIVAGVLMIAGAAGLRRALHGTPGGTWAPRLVRVTGLGMIAAGVLVMDPGDGFPAGTPYGAPQTLSWHAFGHLAAGSISFTALIVACYILGRHFGRAGDRGHALASRLAGTALLIGNAWAMTGGTAGSLTLAVGTITAMTWISWVAARHLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLM9</accession>
    <name>A0A1H6CLM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_110127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73575">
        <property type="protein sequence ID" value="SEG73575"/>
        <property type="gene ID" value="SAMN04489712_110127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG73575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="71" mass="7812" checksum="679EFD57EA119155" modified="2017-01-18" version="1">MKIVADHDRCRGAGQCVFSAPDLFDQSDEDGTVIVLDDHPPPESHARARRAARLCPNSVIRIIENPEPAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM31</accession>
    <name>A0A1H6CM31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73506">
        <property type="protein sequence ID" value="SEG73506"/>
        <property type="gene ID" value="SAMN04489712_110118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG73506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24562" checksum="DC23E4A4AEE544AD" modified="2017-01-18" version="1">MGLRAAVIELGRPGSPFRFVLFPMVHVGDPAFYQAVSRRLRDCDMVVMEGIRGRSRSVSSITRAYHAAKLGRLGLVVQDLDLASLDVPIVYPDMDGREFSQGVRALPLRQRLTWWCLAPVLVPTVLLFGTRAVLASHLTLDDDHGVSARSEGFEEWEALAVDRRDALLIEELARIHEAHGTAPLRVAVVYGAQHMIAVVHTLSARFGYSPRSATWLTVFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMQ1</accession>
    <name>A0A1H6CMQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_110149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73746">
        <property type="protein sequence ID" value="SEG73746"/>
        <property type="gene ID" value="SAMN04489712_110149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG73746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="29067" checksum="408104EE48D48B4C" modified="2017-01-18" version="1">MSRLRAQGLTLAYEQRVVAERLGVEIPDGSFTVIVGPNACGKSTLLRALARLLRPREGTVYLDGGPITELPAKEVARRLGLLPQQPVTPDGITVADLVARGRYPYQGLLRQWSKEDERAVTAAMDAVGVGGLADRIVDELSGGQRQRVWLALVLAQQTPILLLDEPTTFLDIAHQIEVLDLCSRLHEEGRTLVAVLHDLNHACRYATHLVAMRGGEIVAQGRPSDIVTADLVERVFGLPCQIITCPEAGTPLVVPVDRRRALTVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CN51</accession>
    <name>A0A1H6CN51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74370">
        <property type="protein sequence ID" value="SEG74370"/>
        <property type="gene ID" value="SAMN04489712_110219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG74370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="15811" checksum="90703289F7F1BA57" modified="2017-01-18" version="1">MSRDPRELISPDLFDKLTERVMKDEGHDRDMAERVVTQTLVFLVACAQNPGAKLAPSNATDPGWHAFILHTKAYAEFCDRVAGRFIHHLPIMNDDIRSGNALARTVEALHRTGYPVDGELWPEAPTCMNTCNHPCHDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CWI4</accession>
    <name>A0A1H6CWI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77208">
        <property type="protein sequence ID" value="SEG77208"/>
        <property type="gene ID" value="SAMN04489712_111264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="16135" checksum="8084B508B00AD363" modified="2017-01-18" version="1">MPEPDERLYFLLQRAAHQLRTTADRRCLAAAGITTTQLGALLAVHDRPGITQQQLAQTLGLRESAITALVTRLITADLIIRHPHPREHRAVALHLSEHGAATLRAVQPEIDRFNAELRAVLGDTAFTQTTAALNRLTQDDTWPAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3G8</accession>
    <name>A0A1H6D3G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79325">
        <property type="protein sequence ID" value="SEG79325"/>
        <property type="gene ID" value="SAMN04489712_112199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="11443" checksum="66444FEC587D3BB4" modified="2017-01-18" version="1">MLELHGKVLMDAATDLLGRKGELSRELSLAVSALNGLGAFWGGDEAGQAFYTGQGGGGGYQTRSQAIVTEIEAIIDGYEKTALGLQQMSRNTDQANWNVVISLPKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D725</accession>
    <name>A0A1H6D725_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_113111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80603">
        <property type="protein sequence ID" value="SEG80603"/>
        <property type="gene ID" value="SAMN04489712_113111"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG80603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="427" mass="47115" checksum="6978307A37432D79" modified="2017-01-18" version="1">MSDIELDHPGGRMSLEVTTATEGPGGLQIGSLLKETGYVTLDPGFVNTASTTSAITYIDGDAGILRYRGYPIEELAEKSSFLEVAYLLIYGELPSADQLADFTEKISNHTMLHEDFKNFFAGFPRDAHPMAVLSSAVSALSTFYQDSLDPFDPEQVDISSIRLISKLPTIAAYAYKTSIGQPLLYPDNSLSYVENFLRMSFGVPTTPYEVDPEVVKVLDMLFVLHADHEQNCSTSTVRLVGSSHANLFSSISAAVNALWGPLHGGANQAVLEMLEAIHAEGGDVDSFVRRVKAKEPGLKLMGFGHRVYRNYDPRAAVVKKATTKVLDRLGKPDPLLDIAMRLEEVALADDYFVERKLYPNVDFYTGVIYKALGFPTNAFTVLFALGRLPGWIAQWREMMSDPTTKIGRPRQVYLGPGERHYVPIDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D777</accession>
    <name>A0A1H6D777_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81257">
        <property type="protein sequence ID" value="SEG81257"/>
        <property type="gene ID" value="SAMN04489712_1149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="47" mass="5269" checksum="18998115A247A39B" modified="2017-01-18" version="1">MIADGRNQLQSRPHLAFVPATVLFLTILSFSVVGEWLRGRSDEQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAC1</accession>
    <name>A0A1H6DAC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81645">
        <property type="protein sequence ID" value="SEG81645"/>
        <property type="gene ID" value="SAMN04489712_114106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="309" mass="33148" checksum="EFC6CA1BD325FDFC" modified="2017-01-18" version="1">MYQVPDQTGRLAIVTGANSGTGKEAAARLAAAGAHVVLAVRTPAKGEQARTDILAQHPKARLEVRRVDLADLASVRTFTDSLLADGTPVDVLVNNAGVMAPPTRMTTADGFELQFGSNFLGPFALTVQLLPLLLAAQAPRVATMTSGTASYGRIHWDDLQSERRYSAHRAYAQSKLADLMMTRQLAALAHQHRWNLRSTAAHPGYTRTNLQSAGPSLGRDRPKRSFLNSLTFLPSQSPDTGAEPLLYAATDPGAANGGYYGPSGRFNLVGPTGPARLPRRARDADATARLWTLAQDLTETHLAQDLHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBZ2</accession>
    <name>A0A1H6DBZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82694">
        <property type="protein sequence ID" value="SEG82694"/>
        <property type="gene ID" value="SAMN04489712_11565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="14877" checksum="F455A2FF0628B821" modified="2017-01-18" version="1">MSGTHTGVPSVLAYDLPRPVPADELAACPVGDVFRRVGDKWSMLLVILLGGRPHRYNELHRAIEGISQRMLTRTLRALEADGLVRREVHPTVPPSVEYSLTALGRTLLEPLSALADWAVRHEAEINEARSRHTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDV6</accession>
    <name>A0A1H6DDV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hemolysin III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83548">
        <property type="protein sequence ID" value="SEG83548"/>
        <property type="gene ID" value="SAMN04489712_11619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG83548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="24018" checksum="DDDC33238D5A49DD" modified="2017-01-18" version="1">MRVSGELAQAVKPKLRGWLHLGTFPLAVVAGLLLVALGPTLSARLCAAVYAMTSAVLFGVSAAYHRGRWSQRVAERLRRFDHANIYLIIAGTYTPFAYLILEGGARVVVLSVVWGGAVAGVLFRVLWVGAPRWLYTALYIGLGWVAAFFVPQFLEGTGVLVAVLVILGGVLYSAGGLVYGLRRPDPSPRWFGFHEVFHALTVAAYVLQYIAVSVVVYRAGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE79</accession>
    <name>A0A1H6DE79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lysine 2,3-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83531">
        <property type="protein sequence ID" value="SEG83531"/>
        <property type="gene ID" value="SAMN04489712_11614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG83531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="462" mass="52992" checksum="2156466E1421E014" modified="2017-01-18" version="1">MTTPMTTATTGHTGPRPGSAQPYTYRRRPLTEPDWRRLPGWRDVTRAEWESAQWQRAHCVKNVRGLHQVLGDLLDERFYADLRRDQDTRATMSMLVTPQMLNTMDIRDTDAFYADPVRRYMIPVFSDRDADWPSHPRAARDSLHEAEMWAVEGLTHRYPTKVLAEVLPTCPQYCGHCTRMDLVGTSTPAVTKHRFALKPADRHEAMLDYLRRTPGVRDVVVSGGDVANLPWPRLESFVDRLLDIGSVRDIRLASKALMGLPQHWLQDQVRAGMERLAAKARRRGVQIAIHTHVNAARSVTPLVARATRAMLDTGVRDVRNQGVLLRGVNDSPHALLDLSFALLDEAQIMPYYLYLCDMIPGSEHWRLAVWQAQDLQHAIMGYLPGFATPRIVCDVPYVGKRWVHQLAGYDREHGISYWTKNYRTALEATDPQALTRRYEYYDPIHTLPPAGRDWWRRHARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DH27</accession>
    <name>A0A1H6DH27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84559">
        <property type="protein sequence ID" value="SEG84559"/>
        <property type="gene ID" value="SAMN04489712_11725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="14676" checksum="BC4BE9A2A8C11B22" modified="2017-01-18" version="1">MTGTGGIPEVLFVCVHNAGRSQMAAALLDHHAAGRVRVRSAGSAPADSINPAVVAVMDELGLDLTREFPKPLTGAAVEAADVVITMGCGDVCQVFPGKRYEDWRLPDPAGLPVERVRPIRDQIDARVRALLVELLGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHC6</accession>
    <name>A0A1H6DHC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, FSR family, fosmidomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84630">
        <property type="protein sequence ID" value="SEG84630"/>
        <property type="gene ID" value="SAMN04489712_11738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG84630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="39537" checksum="7F8436D272AC65DC" modified="2017-01-18" version="1">MLSIGHACVDVYQGAVAALVPFFVAERAYDYATVSGMVLAASLLSSFVQPMFGALTDRWAMPWLLPVSTLLGGVGIAFSGLSGSYGLTLAFVALSGIGVAAYHPESARVARLASEGSHNAMAWFSTGGNLGFALAPLMVAAAMAAGGLHRTPLLVLPALVGAVLCLPVLRALAHKNATAAAAAMPVGKDDVGSFVKLSLAVVFRSIAFVGLSTFIALHAQQTIGSSAAGTAALFVLYLGGAFGSILGGTLAGRWGRVIVSRWSYLAAVAALAGVVFVPGPALYLFIAATSAGLYIPFSLQVTLSQDYLPSRIGTASGVTLGLTVSIGGLASPLIGVLADHTTLRTALTALILMPALSWLFFRTLPEPTPPRAAPQPTDDTEPARSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJG5</accession>
    <name>A0A1H6DJG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Undecaprenyl-diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84786">
        <property type="protein sequence ID" value="SEG84786"/>
        <property type="gene ID" value="SAMN04489712_11768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="62"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG84786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="228" mass="23593" checksum="20B5E9A0E83631D7" modified="2017-01-18" version="1">MQAPDFSAEWYRSITEFAHGTPPWVHTVAEVGTDAGLLLFAALFVAGWWRARARDARTMALALVCPLVTVAAYLVSEVSKSLIEEERPCRAVAGAMNIAECPAVGDWSFPSNHATIAAASAMALAVAWRTVAPLVLPLAAVMAFSRVFVGVHYPHDVAAGFLLGSLVAAGLALAVAAPAALAVRRLRDLPVTAPLLTAAVLPAQTVPGPATPQDPAAVTGANRDGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMP2</accession>
    <name>A0A1H6DMP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86580">
        <property type="protein sequence ID" value="SEG86580"/>
        <property type="gene ID" value="SAMN04489712_119117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="18746" checksum="F45231DF84337DF9" modified="2017-01-18" version="1">MDQNEITEILNRPLSQELLARDLTRLAYVAQDGTPRNIPIAFTWNGAEIVMCTSTNAPKLRSLRANPMVALTIDTEVHPPKILLIRGRAELDLVEGIPDEYLQMNGSYQMTPEQRVEWEAGVRSLYDGMVRIVVTPTWAKLIDFETTLPSAVEELIRQREERARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPK0</accession>
    <name>A0A1H6DPK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrogen regulatory protein P-II family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87074">
        <property type="protein sequence ID" value="SEG87074"/>
        <property type="gene ID" value="SAMN04489712_12063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG87074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="112" mass="12039" checksum="CE8C94E20DCD0A61" modified="2017-01-18" version="1">MKLITAVIKPFKLDEVKAALETFGVKGLTVSEASGYGRQKGHTEVYRGAEYKVDLVPKLRVEVLVDDADAEDIIDVIVKAAQTGKIGDGKVWAVPVETVVRVRTGETGAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRT7</accession>
    <name>A0A1H6DRT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88087">
        <property type="protein sequence ID" value="SEG88087"/>
        <property type="gene ID" value="SAMN04489712_12173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="17171" checksum="49B0053AC06AC4E3" modified="2017-01-18" version="1">MDKPMHLIEFETMLIGRHRDTTMVRAIRGDRHLDRSAYLLLNRIQLEGPMSIGQLSEAFGLDASTLNRQTSAMLRAGLVERIPDPEGGIARKFHITEEGRHRLDSERAGNIRGLEKVLADWAPEDAAAFAAYLRRFNIDIERLTGKPWPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRX4</accession>
    <name>A0A1H6DRX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87988">
        <property type="protein sequence ID" value="SEG87988"/>
        <property type="gene ID" value="SAMN04489712_12152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="35808" checksum="3F16BEED9969C1AA" modified="2017-01-18" version="1">MKLGLLTAALGRMSLEQVAAWTCQAGYEALEVAAWPVGSEHIHQAAHLDVAGFTAGDADRVRDLMDRYGLTISAVTYCGNNLHGDPAERDRIHRHLRACVDAAAALGVRHVTTFIGRDIDLPVADNLKQAERHLPPLARYAADRGVRLLAENCPMEGWHPDGYPANLAYSPELWDWMAGLGFGLTYDPSHLPWLGIDPLDALDHALQAGIVGHVQAKDIQIDERARTRYGVFGKTAGRASPTDVGWWRYRVPGRGQLDWNRIIDALYAAGYDGDIAVEHEDPVWGGTLDKTLQGMRIAASTLRPLIVAEPEGQSPPSTSLTEPPRPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSG7</accession>
    <name>A0A1H6DSG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88170">
        <property type="protein sequence ID" value="SEG88170"/>
        <property type="gene ID" value="SAMN04489712_12190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="13626" checksum="C6425365EFA459AE" modified="2017-01-18" version="1">MDELDELAQSLRLRGVRVLRVADGVMISLDRGADTARAYVVVIVSWLSGERCFAWGPVRSMRCPAAEVEAAALYLLAHLREAPFGQALPAWPDPVRDCTGAGRLRGRLRQLRARFGATVHGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVC1</accession>
    <name>A0A1H6DVC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89297">
        <property type="protein sequence ID" value="SEG89297"/>
        <property type="gene ID" value="SAMN04489712_12361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG89297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="401" mass="42802" checksum="47E3148944B1AAAA" modified="2017-01-18" version="1">MRRGLVWGCWLATRIVGLLIILDRFPYPRRGEILGDPAIYEEWSRILAGGAFPEGDVRWQYPPLAAPVMLLPRWLGGTYTTTFALVALAADLLIMWLLTRSGRPLAGAWVWTAGLVLLGPMSYVRYDLVVTVAAVAALLMLARHRIFGVLAAVGALLKAWPVLLLAALPRSRRGAEAAAAFAVTCGAVLLVFGLAQGRAPWEFLDAQVSRGLECEAVAATPFMIARLSSWDGTIVYQYGSMELVGPGVERAAALLPPLTVAALLVVAVLAWRGAGRGWNVAWGCDVAFAAVLAAVATSRVLSPQYLLWLLGLAAVCLAHRGSRQRPAVPLILAATALSQFLYPLNWPDLMAAQPLETWILAVRNLLVLAATVIAVARLRTGPSNAGQDPAPSVTGAALPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXC7</accession>
    <name>A0A1H6DXC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89734">
        <property type="protein sequence ID" value="SEG89734"/>
        <property type="gene ID" value="SAMN04489712_12445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="19728" checksum="4120B0092286FB7F" modified="2017-01-18" version="1">MTPGSLILLHPPHATAGAWGGLPELLRSYGLDVIAPDIREGGGMRYVARASLVISAAGPNVPLVLVGRGAAGPLLPAVAAAQRAAHRPIGGYVFVDADLPVHRRPSGPDHDGHDHGHDHGHGNGNAFGPAEGAVPVPADWPEAPCGYLSTRDEQNPPIRQARLRGWPIRTPHAHSGGDIARALNDLIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY51</accession>
    <name>A0A1H6DY51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90161">
        <property type="protein sequence ID" value="SEG90161"/>
        <property type="gene ID" value="SAMN04489712_12556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="28367" checksum="21A9A4892E8735FB" modified="2017-01-18" version="1">MTAIVITGGTDGMGRALARTYLDLGDTVVIVGRDPAKAATLPKAHFIQADLSLVAENRRVIEEINDRYPAVHALVLCARYFRSTRFVTADGFEGTFALEYLSRFLLSHGLHRPRVIVNVSGPAPGVPIGRIYWDDLMLERDYDGVAAQMQAGRANNLLGVAFAARHAAGPTRYVLINPGPVSTSFAGEYDPATAAHVAALKRHGAPVEEGIKPIIARIDAPPAEPLSAFTPADRISLDNPSFAPGDAARLDDLTRYLLRSQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ50</accession>
    <name>A0A1H6DZ50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90409">
        <property type="protein sequence ID" value="SEG90409"/>
        <property type="gene ID" value="SAMN04489712_12628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IclR-ED" evidence="1">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="15097" checksum="8A03B6D22A53296C" modified="2017-01-18" version="1">MKSLGYVRADGRQYSLTPKVLNFGWSYFASLSLEEAVQPVLEDLRTAIDESCSVAVLDGRDIVYLARAFTRRITTSRGRVGSRLPAHATAMGRALLAHLDDDELETWLGQEPLPEYTSRTLTDPAQLRAALAETKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E001</accession>
    <name>A0A1H6E001_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Choline kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90867">
        <property type="protein sequence ID" value="SEG90867"/>
        <property type="gene ID" value="SAMN04489712_12762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="26355" checksum="A41A396C3B5C7E46" modified="2017-01-18" version="1">MIGMVLAAGAGRRLRPYTDTLPKALVPVDGETTILDIALGNLAEVGLTEVVIVVGYCANAVEQRKAALEERYGVSITLVHNDKAEEWNNAYSMWLAREHFAKGVLMVNGDTVHPVGVEKTLLAARGPEIVLAVDDVKTLADEEMKVTLDDSGHLARITKLMDPEQAYGEYIGATLIEPSAAGPLADALKATWEGDPDLYYEDGYQELVNRGGRIAVAPIGAVDWVEVDNHDDLEKARRIAKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E064</accession>
    <name>A0A1H6E064_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG90980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90980">
        <property type="protein sequence ID" value="SEG90980"/>
        <property type="gene ID" value="SAMN04489712_1286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="368"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG90980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="729" mass="78426" checksum="B1FFFD99F2EBB72C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1E3</accession>
    <name>A0A1H6E1E3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90745">
        <property type="protein sequence ID" value="SEG90745"/>
        <property type="gene ID" value="SAMN04489712_12726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="9"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="69" mass="7198" checksum="969325342394E743" modified="2017-01-18" version="1">MNTPDLSAARWRKSSHSGPTGGECVELANLTPHVAVRDSKNPNGPALVFPAAGFAAVLRHIKNGAHDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2V6</accession>
    <name>A0A1H6E2V6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91444">
        <property type="protein sequence ID" value="SEG91444"/>
        <property type="gene ID" value="SAMN04489712_12919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="591" mass="62686" checksum="908323A8BE378479" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3L7</accession>
    <name>A0A1H6E3L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91931">
        <property type="protein sequence ID" value="SEG91931"/>
        <property type="gene ID" value="SAMN04489712_13133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="36839" checksum="BD80012BE18EAB72" modified="2017-01-18" version="1">MAKYAPGEAREWALDSLTGCAGCVQPTFTADLADLNEEAIRHDVRVEKEHGMSAVLLVSESGTTQEEMRRFVEIAADEAGDDLITVLQASQPTLADTLASVEHAATAGVDLVMPSYPLYFNPPSVEEVFHFTKAVTDAADLGVIVFAMDQWNFGRLHAAGFPLSLLTRMVDEIPGVVAIKNEVGGPGVGGIAAVFEALRDRVVVTDPLEFNAPAWIANYGMRFMGTSNYECMGPAVPQMLDLLSDKATWDEGMELYWRLHPVRKANAAVCTPLVAGSGLVPRMHWKYQGWLMGYNGGPIRQPHMRISAAQMAALRSAAVAAGLPVTADDDELFYTGRNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3Q4</accession>
    <name>A0A1H6E3Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91525">
        <property type="protein sequence ID" value="SEG91525"/>
        <property type="gene ID" value="SAMN04489712_12948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="20468" checksum="3E599BD36493E6F1" modified="2017-01-18" version="1">MNNDELREHNKNRKIYQIAFVTRDLEKSMKAWVENLGIGPWTVLTFTEETMKYLNVADAKVTEPFKFLIGISWVGDMQLEIVQPVYGPTIYEEFLDRRGEGLHHIKEQISDDRIEAELADYRSRGIGVLQTGQFDVDVHYYMDTEPKLDFIYELGNCPVLDLPPHMVSTYPPQNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3R8</accession>
    <name>A0A1H6E3R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92282">
        <property type="protein sequence ID" value="SEG92282"/>
        <property type="gene ID" value="SAMN04489712_1334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="21236" checksum="4E725869B5E6CED4" modified="2017-01-18" version="1">MQGPYQPYAPIPPGPPLPPRRDRANLVPLFIIIGVLAVALLGTLTYLVVKVGGDDDLRTGTVVTPTRAANPRAINAAFSGTWTGSGYYHNNDGEKRNFDATLTLTEGGETGTSSYTGFVCSGTLRVESVTPDKVVMYEVITQGNEPGGNCSDAATGYVTLTLRSDGTVLYSWYGNRDKMLSGDTSSQATLSRQQSSTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3X3</accession>
    <name>A0A1H6E3X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_13324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92350">
        <property type="protein sequence ID" value="SEG92350"/>
        <property type="gene ID" value="SAMN04489712_13324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG92350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="15434" checksum="EB5B3EEBE2700ED1" modified="2017-01-18" version="1">MTHSPPYDAGAGDFDDPNGDHLRETGPQEPRHDGRDAPDRPLPDEADEEADDARSRAAELAELRRYEAEREDKRRRRDSASRKAVAWIVAVALAFLLYDSGGALARGTSEDGPWTAHAVLAGLAALGLLGLLVAGIRALRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3Z2</accession>
    <name>A0A1H6E3Z2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_13330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92370">
        <property type="protein sequence ID" value="SEG92370"/>
        <property type="gene ID" value="SAMN04489712_13330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG92370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="103" mass="11469" checksum="CE6ADB085500226F" modified="2017-01-18" version="1">MDSVPLREARNRLGKICTAAAHAGTVTEITRHGGDPVVVIPRSAYEELQRLRRADVERQTREAAEYLRRGEIPPGTERVTREDLMASIADNGADNGMDRQERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E405</accession>
    <name>A0A1H6E405_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92372">
        <property type="protein sequence ID" value="SEG92372"/>
        <property type="gene ID" value="SAMN04489712_13331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="81" mass="9091" checksum="5F3C4F56330F1BEB" modified="2017-01-18" version="1">MPDHLLYAYGIRREVAGFPAHIRRAAELAILGLLDDPVPPHAKPFIEDLGHASYELPTEYATIYYLVIDDTVMITKVLPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4D8</accession>
    <name>A0A1H6E4D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92103">
        <property type="protein sequence ID" value="SEG92103"/>
        <property type="gene ID" value="SAMN04489712_13224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="59" mass="6236" checksum="9534B7D49A597BC6" modified="2017-01-18" version="1">MALGRLADYSSLLPPAVRAILLPERPKRADLIAPAHSQGVAVLWPEGTGYGSSDPAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4Q4</accession>
    <name>A0A1H6E4Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyribose-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92271">
        <property type="protein sequence ID" value="SEG92271"/>
        <property type="gene ID" value="SAMN04489712_1331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="58" mass="5820" checksum="B47733892F51AC67" modified="2017-01-18" version="1" fragment="single">MGDAGRVSTETLTDAPGGNAGLRAFLHGLPGVDQVGAEERAARLGTRSIKASAKAEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E517</accession>
    <name>A0A1H6E517_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92309">
        <property type="protein sequence ID" value="SEG92309"/>
        <property type="gene ID" value="SAMN04489712_13312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="35"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="28593" checksum="26021DD09A53CE08" modified="2017-01-18" version="1">MPSTTARARQHRSAVSPHVDRLVDFTEPSPADECLDLSHGRGPLPAALEPLVRRVTAVDTTQVTAGTTGPLPVPRGSGSGGRTPTVLFDRSRTHGGGPGSSAVRADACALPYRDGTFTLVTSRFSLRRLGDPAQVLREMVRVCRPGGRVVIAEAVRPAYDAPERDRLERLRDPGHPGLATVDGLTRLLAEAGAHVRRLERINVERPLEPWLADAPDPHGADDIRHALVNEVDGGPRTGARPRVIGGEMWFTQTWAYLAAEPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E567</accession>
    <name>A0A1H6E567_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_1364</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92898">
        <property type="protein sequence ID" value="SEG92898"/>
        <property type="gene ID" value="SAMN04489712_1364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="293"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG92898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="376" mass="41811" checksum="7CDB8BED5E87C079" modified="2017-01-18" version="1">MDLQEFRTGLDAWLDEHEPELRAESGPDLTLDEEMEHLSKVKRMTYDAGWMRRGWPERVGGLGGSTLMRAYLGEALASRDLIEPGVYSMTEVLAPTMIEFARPELAAEMVPRLLRGDETWCQGFSEPSTGSNLGSLSCRARRDGDAWRVTGQKVWTSLAQYAHRCVLLTRTGSPESSHRGITAMFVDMDSPGITVRPIRAIHGRDEFCEVFFDDVRVPVDRTLGEVGGGWAVAMDLLPYERSTSLWHRGAYLRQRLGRLLATVPDGAIDPGDLGEVVQMVFAFHARSRGTQHRMARGERLGPETSIDKVLLATTEQAVFDLVADAVPTAIAIGDDADGDRWRTEFLYSRAATIYGGSAEIQRNIIARRLLDLGTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5I0</accession>
    <name>A0A1H6E5I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_13622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92942">
        <property type="protein sequence ID" value="SEG92942"/>
        <property type="gene ID" value="SAMN04489712_13622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG92942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="368" mass="38616" checksum="BB32FEE431209BF2" modified="2017-01-18" version="1">MTTDAIKDRTGAGVLGRTLGRMLGRQGSGTQFVMGAGLLAAALWALNGGPFLNLVGQSCAVYAVAAIGQSVLIGSAGQIALSGAAFMAIGAFVTGSLAGTPLETFPFPLLICAVVGWLVGLLSGLPGLRFRGLYLLLSSLALQFMVTAVTKNYQSARHPAGLEVPPLHIGPLDVSTGQSFYIVLITLLATVYLVVALVERTGVGLAWRAIRESEEAAAVSGVDAVRWKLYAFAMSGAITAVAGCLMAYLVGRADYETYNLNLSIALITMIYIGGIRSRLGALTGAVIITALPYILQLRLPGWLAGLGIDANWYTENQSIANAGLFNLLFLLVVLFEPEGVQGLLGKAERLLRRTLSGRRTGRTTESPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E615</accession>
    <name>A0A1H6E615_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92693">
        <property type="protein sequence ID" value="SEG92693"/>
        <property type="gene ID" value="SAMN04489712_1353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="26297" checksum="AD6BB6B7816373AF" modified="2017-01-18" version="1">MERLTDRRVLITGAASGIGRATALRLLAEGARVVAADVAEDGLKETLALADQAGTADRLTTKSVDIADESSVDVVVTAAVTELGGLDALVNAAAILRGAHTHDCSLELWNRVITVNLTGTFLMTRAALPALLETGRGVVVNFSSTSAFFAHPFMAAYSASKGGIASFTHGLALEYSKQGLRAVNVVPGGISSGITNNIGSLVPEDVDWNLFSKLTAAIGNGLPGPENVAGVVAMLISDDGAFITGTEIRIDGGAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8L2</accession>
    <name>A0A1H6E8L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93195">
        <property type="protein sequence ID" value="SEG93195"/>
        <property type="gene ID" value="SAMN04489712_13741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020311">
        <property type="entry name" value="Uncharacterised_Rv0898c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10944">
        <property type="entry name" value="DUF2630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="81" mass="9726" checksum="A2122D58D26BC56D" modified="2017-01-18" version="1">MDERDILVRIGELVEEERRLRDLHERGELNQAEEQRRLMRLEVALDQFWDLLRQRRAKDRAGEDPDEADVRPPGEVEGYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9F0</accession>
    <name>A0A1H6E9F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_13932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93566">
        <property type="protein sequence ID" value="SEG93566"/>
        <property type="gene ID" value="SAMN04489712_13932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="166"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG93566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="457" mass="52609" checksum="0D5C2EB0B1116E63" modified="2017-01-18" version="1">MGYAKKRTNKAGKTRYTAVYIDLQGRTRSAGTFSNKKDANTAWQDKEVELRQGKVGDPKRGQMTLRKYATEVWLPNHRIEPKTREKYTGYLDKHILPELGPMKMADIFPEHIRQWITSLQSRGVSPWVIQSCKNSILNALFTTALNDQITYLHPCRGVRIPTVPSTPRTIITPEQFDLLYQALGEPDHQLLVETDIETGLRWGELIELRVKDLDLATRMLTVSRKATEISPRFHPEGKRFLITRYPKDKEFRRLKLSKQITEKLKAHINAHRLGSEDLLFARRVQARPPIRNQVVADPAELGLTPPNAKGRQYQHGTISAYNAAPCRCDHCRAAYARYRAERRAAGKDNPRTPRTIDDEHIPRNWFRRHVWRPALKAADLGITPRVHDLRHSHASWLLHGGADLQIVKDRLGHASIVTTQKYLHTLPEADDAAIDAFTKIRQRSKKDKKRKQRKDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9M0</accession>
    <name>A0A1H6E9M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxosteroid 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93654">
        <property type="protein sequence ID" value="SEG93654"/>
        <property type="gene ID" value="SAMN04489712_1405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="13"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG93654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="555" mass="60596" checksum="F0A32DDA6C4FA017" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB47</accession>
    <name>A0A1H6EB47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000057">
        <property type="protein sequence ID" value="SEG94977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94977">
        <property type="protein sequence ID" value="SEG94977"/>
        <property type="gene ID" value="SAMN04489712_1572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="11122" checksum="A2646433E9421D21" modified="2017-01-18" version="1">MAAARARTRTFGALQAAGAALVASREEVARLRGLLVRARQDLALLRAEDAELLAYARATVAAARAGDPDPVAILAGLLEERGQLPSDGTSPAALLAQGYRTGQAGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EC87</accession>
    <name>A0A1H6EC87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000047">
        <property type="protein sequence ID" value="SEG94395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94395">
        <property type="protein sequence ID" value="SEG94395"/>
        <property type="gene ID" value="SAMN04489712_1477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG94395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="332" mass="35234" checksum="F2178DAE500D926F" modified="2017-01-18" version="1">MTLHPSPLPAEPHDGPEPLGPVNSALVPRFAGPATFARLPRLDQVRRADVGIVGVPFDAGVSYRPGARFGPAAVREASRLLRPYNPAQDLSPFQAAQVVDAGDIACNPFDIGEAIGTVQSTVAQVAARCDRVVTIGGDHTIALPLLREARERFGEPLALIHFDAHLDTWDTYFGAAYTHGTPFRRAHEEGLLAEGACAHVGTRGPLYGRIDLDEDARMGFGIVTSDDFQSRTVDDVAEELVRRVGDRPVYVSVDIDVLDPAHAPGTGTPEAGGLTSRELLGVLRRLAAAQIVGADVVEVAPAYDHAQLTAVAAGHVVYELVTVLAGKVADTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5RYP3</accession>
    <name>A0A1H5RYP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43234">
        <property type="protein sequence ID" value="SEF43234"/>
        <property type="gene ID" value="SAMN04489712_1011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF43234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="355" mass="37375" checksum="4B6F722E1AAE836E" modified="2017-01-18" version="1" fragment="single">EAQNPERSPHRKAGPCALRGMRSADVVDARSEGARLAAAVSLLLAAAKTRDHIVDRDKAYGRKLVAVGAGHMADRWDAAGARTGSALGFDASVLRKAVERQARLEAVGGLGLLELTEPTETAVAAAFAHTAVLAGKPHNVEALGEAGRFFGRLAHLIDAVEDLEEDRARGVYNPLLATGTDLAEARRYCEDALHGLRLAIADLDLEDRRLVKALLDREIGRSVDRVFAAYPGGPPGSHGPGPQGPYGPSYQDPYGRQPGHPAGHPPHTPMGPGSPGGGDWSGGGGGFGGFGGGHGRPRRPGFPIPCFADTLVGCTCGLYQPKWSKYRDKSCSGRCWCTRNGNCCECCDSCDCCDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SZI6</accession>
    <name>A0A1H5SZI6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">SAMN04489712_101401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55207">
        <property type="protein sequence ID" value="SEF55207"/>
        <property type="gene ID" value="SAMN04489712_101401"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="10">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="9">
        <location>
            <begin position="244"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="385"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="271"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="513"/>
            <end position="516"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF55207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="604" mass="66527" checksum="D4D4A7311FE189E0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TAS4</accession>
    <name>A0A1H5TAS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59087">
        <property type="protein sequence ID" value="SEF59087"/>
        <property type="gene ID" value="SAMN04489712_101523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF59087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="28950" checksum="00B64A7EC2244268" modified="2017-01-18" version="1">MAESPTELLWQVTVQGVARLTLNRPKAGNSITAGQREEIIGLLGRASGDPRVRAIVLTGAGERHFCTGADLSGSTGPLTDDAPPDAPERPAGSVARAVAGGAQRLITAVLDCDKPVIAAVNGTAAGLGCHLAYACDLVLAADSARFIEVFVRRGLVVDGAGAYLLARLVGPQRAKELVFFGDDLPAAEAHRMGLINRIVPAGELDKTAEEWAVRLAAGPTVALGLGKRLINRSLEVDRTTALAEEAMAAEINMTSEDGREGLRAFAERRAPVFRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TQI1</accession>
    <name>A0A1H5TQI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase, activator-dependent family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65122">
        <property type="protein sequence ID" value="SEF65122"/>
        <property type="gene ID" value="SAMN04489712_101712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="DUF1205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030953">
        <property type="entry name" value="Glycosyl_450act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="DUF1205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04516">
        <property type="entry name" value="glycosyl_450act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1205" evidence="4">
        <location>
            <begin position="209"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF65122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="426" mass="46883" checksum="D992F8CAF71E51A4" modified="2017-01-18" version="1">MRVLFFAPPAKVHVFAQVPLAWALRAAGHEVRAANRPNMLDDITRAGLAAVPVGPSFDPGSFVGEEEREPLPWESWQEVLEFAELRPEKLTYDYMHAVFAAWTLVFQGVSPPEVMADLVRFARSWKPDLVLWDTLAFAGPVAARACGAAHARLLFGLDVIGRMRGTYLEAVRRRPVELREDPLQEWLSPVLERHGGGFDEDVVMGRWTVDPLPSSLRLEVDHHYVPMRHVPYHGPAAVPDWLLEPPKRRRVCLTLGLSVREVLGGDRVSIGDLLEAVADLDAEVVATLNADQLAGIRRLPDNVRAVDFVPLNELLPSCSAILHQGGFGTLQAAVTHGVPQVILPPRAGDWDSRIWAHRVQGAGAGLSAPDSRRVTAGEVRAMLDRVLAEPSFGAGAERLRTEMIGTPAPREVVPVLERLTARCRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U161</accession>
    <name>A0A1H5U161_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ribulose 5-phosphate 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68017">
        <property type="protein sequence ID" value="SEF68017"/>
        <property type="gene ID" value="SAMN04489712_101801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="11"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF68017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="23460" checksum="8796FD518A771F5F" modified="2017-01-18" version="1">MNETAYAQVRVDLVDLHRVLVQSELVVWTAGNVSAKVGDGHFLIKPSGVAYERLTPESMVLCDLDGHPVEAGLKPSSDVFAHAYVYRHRPDVGGVAHTHSTYATAWAARNEPIPCVLTAMADEFGGEIPVGPFALIGGDDIGRGIVETLAGSRSPAVLLRNHGVFTVGASARDAVKAAVMCEDVARTVHIARQLGEPLPMEQGDVDRLYDRYQNVYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U204</accession>
    <name>A0A1H5U204_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68448">
        <property type="protein sequence ID" value="SEF68448"/>
        <property type="gene ID" value="SAMN04489712_101817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_C" evidence="1">
        <location>
            <begin position="249"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF68448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="380" mass="39580" checksum="CCE9CB34DC30E936" modified="2017-01-18" version="1">MTVAIVGAAESDLGVTGKSILTLQAQGITRALADAGLSLSDVDGLATAGLSRFSTAQLAEYLGLEPSWSDSTFAGGSAFEMYVARAVQAIEAGQCSTVVISYGSNQRSARSRSLGGVQEAHIPQAQFEDPYAPLFPLSYYAMAAQRYLHSYGGGREWLAEVAVAAREWALLNPKAFRHEAGPLTVEEVLAAKPVSSPLTVADCCLVTDGGGAIVLTSLERARDLPKPPVVVLGYGESTTNASMTAVDDLLRPGSFASGQTAFRMSGLNPSDVDVLEVYDSFTITVLLTLEGLGFCKPGEAGELAASGRIRPGGDLPLNTSGGGLSYNHPGMFGLLLLIEAVRQVRGECGERQVPDAEIALAHGTGGIFSTHATVLLGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VDD5</accession>
    <name>A0A1H5VDD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85319">
        <property type="protein sequence ID" value="SEF85319"/>
        <property type="gene ID" value="SAMN04489712_102275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisKA_3" evidence="1">
        <location>
            <begin position="181"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF85319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="385" mass="41390" checksum="78C0E2C83DCFEA22" modified="2017-01-18" version="1">MTGGGARTDDPASPVCRRIDAILERYRGRLAELGNPLAADDVLWERHARWSRRVIEESLRPEDPAGAPAGRQSVCGGARGGPRAAVGAPGLAEAGHTLFAVVMRSLEESARQGAIEGETVARVAVALHGRITSWLASHGGRHQILGRPAEPFGRAERAGRIERTGRVERADLTEPIETRVRREVAREVHDRIGGSLYLAMRQLELLQLLAGGRPERPEAATARLEAVRSALLQLNADTRDLVAGLRRPHSAGSLEAALRSFVDALAHPRTTVHLQVSEELDALPARLRDELFLVVRECLRNCLAHAAAPNVWARIDVDPAEVAVRVVDDGVGFDLAEVAARGTTNGLSGLGERVAALHGEHLVESRPGHGTRITISIPIRAPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VFF2</accession>
    <name>A0A1H5VFF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein SAMN04489712_102303</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86049">
        <property type="protein sequence ID" value="SEF86049"/>
        <property type="gene ID" value="SAMN04489712_102303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF86049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="154" mass="16973" checksum="54ADB5771B8DD636" modified="2017-01-18" version="1">MTLDRTFVGRVYRDERYYEVGREKIREFAEAVGDPHPAFTDPAAAQALGRPDVIAPPTFPIVLSMRAESAAVLDPRLGFDFSRVVHREQRFAYARPVRAGDRLTVTVTITRADTVGGNDLVEFDSEIRTTGGELVCTTTTSLVSRAPGDETETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VIZ1</accession>
    <name>A0A1H5VIZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87204">
        <property type="protein sequence ID" value="SEF87204"/>
        <property type="gene ID" value="SAMN04489712_102340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF87204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="12347" checksum="105AE88987808166" modified="2017-01-18" version="1">MKYMLLIHSAATDQAAACESSFEDWQVYDKAVKEAGILVDAHSLADLTTATTVRVDPSGERAITTDGPFAETREVLGGYYVIDVPDLDVALDWAARCPGARDGGSVVVRPIADFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VJN3</accession>
    <name>A0A1H5VJN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87236">
        <property type="protein sequence ID" value="SEF87236"/>
        <property type="gene ID" value="SAMN04489712_102341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF87236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="45385" checksum="BFCCFC654B3D9DE2" modified="2017-01-18" version="1">MDGRVAETMTSVEAMFREERGRLLASLVRRFGDLDLAEEVASEAIEAALVHWPVDGVPASPGAWLLTTARRKAVDRLRRDRTYAARLAVLQVEVDRAGPAPPADADGDLPDERLQLFFTCAHPALPAEDRAALTLRCLAGLTTAEVARAFLVPSATMAQRIVRAKRKIRQARIPFRVPGADELPQRLPGVLQVLYSIFTEGYAASSGPDLQRPGLAEEAARLARILRRLLPAEREVAGLLGLMLLVHARRDARTGPDGGLVLLEDQDRGRWDRAMIEEGRGLVLAALTGGPPGPYGVQAAIAALHDEAADVATTDWPQIVALYDVLLALTPSPVVALNRAAAVAMRDGPEAGLALLDELAGEPRLRGHHPYPAARADLLHRLGRFHEAAAAYREALDLAGTEPERAHLRRRLNAIEEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VMU5</accession>
    <name>A0A1H5VMU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87847">
        <property type="protein sequence ID" value="SEF87847"/>
        <property type="gene ID" value="SAMN04489712_102358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF87847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="460" mass="51217" checksum="AB8371F976C41FA5" modified="2017-01-18" version="1">MSTAIGAESGTPDASLERVSPRRLVSLYRQGGPLHALESIGRAAEGAVARIDLGPFRPYLVTDPAHVQHVLRDRADNYERGAVMWKPVSRLVGNGISSEGTPWRSSREVLAKVFSGQYIGRFTERMAEAINAAADDLLARATREPVDVRREMNRLMHRAISLVFFDDRLPVEDIDRLGTAVSAASGSFMSRMAMPFMPNAVPMPGDLTFRRATRTVDEILGPLVAEGRRRPPGGHDVVSKLIEAREADGTPFSDQRVRDDVVGLFVAGTESTADGLTWLWVALDEHPEHAARVYAEIEREVGDGRAGPEHVRRLPYTQMFLQEVLRLHSVGWAVPRMAVADDVIGGVPIKAGSTVVLSPYLTHRDRRVWERPEEFDPERFTPERVKERVQRYGRFAYFPFGAGEHVCLGEQLFKIETTLIMASLLGRARPVLHRSEPIEPKLTLTVRPSRPVELMLAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W6G3</accession>
    <name>A0A1H5W6G3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="6" type="ORF">SAMN04489712_102608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95075">
        <property type="protein sequence ID" value="SEF95075"/>
        <property type="gene ID" value="SAMN04489712_102608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF95075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="371" mass="41538" checksum="44BC7BE173C2E540" modified="2017-01-18" version="1">MAGIDPVEQLKELGSTLTGIEAVLDLDGMRADIAKLREESADPDLWNDQDRAQQVTRRLSHLESEFTRVTSLRQRLEDVTTLYELAEEMDDADTRAEADGELATLQRDIQQLEVRTLMSGEYDAREALVTINAQAGGVDAADWAQQLQRMYLRWAERHGYPTEIYDTSYAEEAGIKSTTFAVKAPYAYGTLRGEHGTHRLVRISPFDNQGRRQTSFAGLDVVPVVEQSDHVEIDESDLRIDVYRSSGPGGQGVNTTDSAVRITHLPTGIVVSCQNERSQLQNRASAMAVLQAKLLERKRQEEAAKMADLRGEGTTSWGTQIRNYVLHPYQIVKDLRTGVEAGNPASVLDGEIDDFIEAEIRWMRQRESEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W7T0</accession>
    <name>A0A1H5W7T0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_102615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95276">
        <property type="protein sequence ID" value="SEF95276"/>
        <property type="gene ID" value="SAMN04489712_102615"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="56"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF95276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="543" mass="58836" checksum="1B49949E09E28893" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WCH6</accession>
    <name>A0A1H5WCH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen triple helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97164">
        <property type="protein sequence ID" value="SEF97164"/>
        <property type="gene ID" value="SAMN04489712_102667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043777">
        <property type="entry name" value="DUF5719"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18986">
        <property type="entry name" value="DUF5719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF97164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="629" mass="63747" checksum="45A4B752AA2CF0BE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X538</accession>
    <name>A0A1H5X538_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06882">
        <property type="protein sequence ID" value="SEG06882"/>
        <property type="gene ID" value="SAMN04489712_10392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="135"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG06882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="36295" checksum="BAD0353EF61CCF62" modified="2017-01-18" version="1">MRIGLAGAGRIGARHARTLRTLPAVQTLVVADADPARARSLRDRAAGAGGADVVAVDSVDALFRAGLDGLVVAAATDAHAELVLRAARARLPVFCEKPLAADLDGTVQVVAATRDVPVQVGFQRRFDAGHLAARAAVADGRLGWLHTMRSCTFDPAPPPREYVPGSGGLFRDCGVHDFDAIRFVSGREIVRVVAVGANRGDGFFREYGDVDTATAVLTLDDDTIATVSATRYNAAGYDVRLEVFGSRDSIVAGLDEHTPLTPVGPGRIPAPAAPYRGFMERFAAAYDAELSAFVDVVAGRREPPCLPEQALEAFYVAEACEVSRHEGRPVAVAEIRERTTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XC77</accession>
    <name>A0A1H5XC77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid/cholesterol/gamma-HCH transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08816">
        <property type="protein sequence ID" value="SEG08816"/>
        <property type="gene ID" value="SAMN04489712_103169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG08816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="30809" checksum="0B7878E83E7BA6A7" modified="2017-01-18" version="1">MAGPLLPTRIGARAAGTADVLLRRSADLARWPVFLYRVVLCSLRDLVWRRRYARTVARHVSDVVVGAGATVVGGGMIFVIFTMAFFVGTEVGLQGYTGLRSIGAESFMGLVGSFANVREITPVIAATALAAQCGSAFTAELGAMRISEEIDALEVMGIDSFAYLVCTRVVAALIALVPLYLIALFASFFATRLISTEFFDLAPGVYDHYFRLYLPTIDLVYSSIKVAVFAFAVIAIHCYYGYHATGGPAGVGHAAGRAIRLSIVTIVTLNLLLSYVFWGGGATVRLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XEU7</accession>
    <name>A0A1H5XEU7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aconitate hydratase</fullName>
            <shortName evidence="10">Aconitase</shortName>
            <ecNumber evidence="10">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_103223</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10271">
        <property type="protein sequence ID" value="SEG10271"/>
        <property type="gene ID" value="SAMN04489712_103223"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="12">
        <location>
            <begin position="71"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="13">
        <location>
            <begin position="720"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG10271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="922" mass="100391" checksum="B84C74715664682B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XI37</accession>
    <name>A0A1H5XI37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11418">
        <property type="protein sequence ID" value="SEG11418"/>
        <property type="gene ID" value="SAMN04489712_103266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG11418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="570" mass="58608" checksum="66F9F5E74CC7463A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XU21</accession>
    <name>A0A1H5XU21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SnoaL-like polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15153">
        <property type="protein sequence ID" value="SEG15153"/>
        <property type="gene ID" value="SAMN04489712_103406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG15153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="15042" checksum="F06F96BBE1662A66" modified="2017-01-18" version="1">MIAIADLYRRWLGELWQGDLKVLHELCAPDFIGHWPDRDVRGVQEAAEQIGRTFTLFDKVATTIEVGPLVDGDLVSAHWTFAGDYRGGLPGATAAPGTRVSFTGMDMLRVTDGRFKEYWVVSDALGLMTRLGVFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XWV0</accession>
    <name>A0A1H5XWV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15927">
        <property type="protein sequence ID" value="SEG15927"/>
        <property type="gene ID" value="SAMN04489712_103436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
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    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG15927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="29084" checksum="1C65AD2F462D57EB" modified="2017-01-18" version="1">MTGEQAPSGVDVTTPNVARIYDYFLGGKDNYAADRAAAEQIMQTVPEAPLAARANRAFLTRAVRFLAAEAGIRQFVDIGAGLPTQGNVHEVARRAIPDARVAYVDNDPVVLAHGRALLAGDDLVTVVQGDLRRPEEILGEPALRELIDLDRPVAVLLVAVLHFIADAEDPYAMVERLLDGLPSGSHLVISHGYQGGMDQDASTRAEGVYRRSTSAIHSRDPGQVRRFFGDWTVLDPGVVWITQWRPESTDEITDPSTTHFLGAMGHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XY42</accession>
    <name>A0A1H5XY42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase inhibitor, KipI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16588">
        <property type="protein sequence ID" value="SEG16588"/>
        <property type="gene ID" value="SAMN04489712_103464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00370">
        <property type="entry name" value="TIGR00370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG16588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="21484" checksum="441A96A716A5F399" modified="2017-01-18" version="1">MLVRRAGDAAVLVEVGDLPTAHRLHAAVCGAGFTGILDVVPGERTVLIVADPDRCDLDRLAARLAALELPDGPQDGLVPVEIPVVYDGQDVAEVAGLTGLSAEEVVRRHSSGVYVVAYLGFSPGFGYLTGLDPALHVPRRRTPRTSVPAGSVAIAGPYAAVYPSASPGGWRLLGRTELALWDVRRASPALLRPGARVRFVPVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y2G6</accession>
    <name>A0A1H5Y2G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17985">
        <property type="protein sequence ID" value="SEG17985"/>
        <property type="gene ID" value="SAMN04489712_103517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290078" evidence="1">
        <location>
            <begin position="40"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="298" mass="32528" checksum="EB557B63F0801CE3" modified="2017-01-18" version="1">MRNPPRPRIHRPGTVRALAVALAMLASVLLPAIVSPANALAFPTPRSFVSNLDLECFRTEAYTPPTGPILTTHLNPVLADLPREQIVLGPREQLCVPVAKNGVIPPQDVLGFIRYVDLSCYRTQGINVNRQLNLRHLNPVLTGLPPTNVVMTSPQQLCVPVIKNGVVPPDEVLRLVQYIDLKCYLIGPQAPLNRPLSLTQLNPVLTGLPVSNVNVTYNRQLCVPVQKGDQQIPPEVLNIVRWLDLVKYDLQAPALPVVPLTLTHINPMLAGLPKEQVTLNSPPQLAVPVAKNGVIPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YKG9</accession>
    <name>A0A1H5YKG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24162">
        <property type="protein sequence ID" value="SEG24162"/>
        <property type="gene ID" value="SAMN04489712_10445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG24162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="65" mass="6674" checksum="DE5EB2CA41024F2E" modified="2017-01-18" version="1">MDLLTATWRKSSRSGNNGGACVEVAQLGTAIGLRDSKNPDAGHLTVPAKTFAALLTHLKQGGPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YMH4</accession>
    <name>A0A1H5YMH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type branched-chain amino acid transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25353">
        <property type="protein sequence ID" value="SEG25353"/>
        <property type="gene ID" value="SAMN04489712_10491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290729" evidence="1">
        <location>
            <begin position="23"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="45"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG25353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="412" mass="43973" checksum="1529989B2A8AA458" modified="2017-01-18" version="1">MSTYRTNGMSRRGFLTGTTSVAALGMLGLGTAACGSSGGGGKATARIGWVEPKTGRLAAAYKPIYVGARLALEDLKAGGGLLGQAVQLMEEDDKGSPAAQPAVAQRLIREEPTFVVGPTGSSQVLASVTALARAKLIQSCWGGAELLGDGDRFPYHYQLVYNTTQQAEVAARFLHEVRGLRKIGIIVENSEFGTSIRDAVVRILRDTYSAKPVAVEVFEVDASDMTPFVRNLERAGVDGLGLFTGQPQATILILRAMAASDFHPVIVSHDLNYIEALGEFPRALLDGFFGTTYRGLTYTDAEEPSAAVHGLVERINKHPDTAGLGYSAVTSPYYDYMLLMAKVIEETKSLEPAKLKAALDKVEDYQGVRAKVSFTAKRHSGIAAEDITVGTLVSAKEPQSLGGVLRRRADGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YN27</accession>
    <name>A0A1H5YN27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25563">
        <property type="protein sequence ID" value="SEG25563"/>
        <property type="gene ID" value="SAMN04489712_10499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG25563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="29272" checksum="173EAFAFF52D9A61" modified="2017-01-18" version="1">MRRDQESTASGGTETLLVSRPAPGVLWLTMNRPARRNALDRALGEELLRALEHAETDPQARVVVLTGAGSAFCGGDDLGAVDEHLAGDRRHSPVLGDTADPVYLRIVEAIVTSPQPVIAAVNGPAAGAGTELACAADLRIASDTARIGSCLVNVAQTGTAVMLPRIVGTAKATEIYLSGGLLDAADAERLGIYTRVVPFGELQDVVLAEARRLAAGPTRAIGLYKQLRERVYGQPLEQALRIQNGFHIRNNREVHDAVEGARAFVEKRSPEFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YT80</accession>
    <name>A0A1H5YT80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27030">
        <property type="protein sequence ID" value="SEG27030"/>
        <property type="gene ID" value="SAMN04489712_104160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="196"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG27030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="436" mass="47323" checksum="B7F6ED77EFE16D72" modified="2017-01-18" version="1">MDGRRGAEDEVVGLCQELIRIDTSNPGDHSGPGERVAAEYVAGKLAEVGLEPVVLESHPGRTSVIARIEGEDPGRDALLLHGHLDVVPARAEDWTRDPFGGEIADGCVWGRGAVDMKDMDAMILAVVRERLREGRRPPRDVVVAFLADEEAGGRWGAQWLVDEHPELFEGCTEAVGEVGGFSLTVPGDRRMYLIETAEKGIGWMRLTARGTAGHGSMVHPDNAVTAVAAAVARLGSHEFPLRLTKTVRAFLERACLAYGVEFDPDHPEKCLAEIGPLARMIGATLRNTLNPTRLDAGYKVNVIPQEASAQVDGRFLPGYEEEFFATVDELLGPDVTREFVHHDHAIETEYEGALVAAMEAALTSEDPGALPVPYCLSGGTDAKAFARLGMRCFGFAPLRLPPELDFSGMFHGVDERVPVDGLRFGVRVLDRFLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXE6</accession>
    <name>A0A1H5YXE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28741">
        <property type="protein sequence ID" value="SEG28741"/>
        <property type="gene ID" value="SAMN04489712_104236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291045" evidence="1">
        <location>
            <begin position="30"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="123"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG28741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="26727" checksum="0F96554F4D550444" modified="2017-01-18" version="1">MGKRALCSAMLVLPAAGLVAVGVAAPVTAAAPLPLTGKVIVIDPGHNGLNYRYPGKINRPVPAGPNKKACDTTGTATNSGYAEHAYNFDVAVRLAKILRARGAKVRLTRPDDRGVGPCINERAAIANRLRADAAVSIHADGAPSARRGFHVIVPGLVKGYTEPIVAPSRRLGTRIRNTFRDGTGQPYADYAGRNGIDVRTDLGGLNLSKVPKVFIECGNMRNATDAARMKNPTWRQRAAQSLATGLTRYLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXM3</accession>
    <name>A0A1H5YXM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29029">
        <property type="protein sequence ID" value="SEG29029"/>
        <property type="gene ID" value="SAMN04489712_104249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG29029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="14002" checksum="8A1939B3AEFD3532" modified="2017-01-18" version="1">MAAGLAADAVVHWVFASDMAFVEGGSIAGDDLFRAQAILAAIAAVLVVVWARRWTYAVAFLVAASAVGALLLYYYVDVGPLGPLPQMYDPAWYTEKTISLVGEGVAALAALAGMLLPARSDDRSPSGAPDRAGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YYR7</accession>
    <name>A0A1H5YYR7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_104216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28306">
        <property type="protein sequence ID" value="SEG28306"/>
        <property type="gene ID" value="SAMN04489712_104216"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="12">
        <location>
            <begin position="32"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="119"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG28306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="29433" checksum="632C71303CDF50DC" modified="2017-01-18" version="1">MTPELEGLLAGAGLDPRAVADLARTALTEDGEVDVTSEPIFAPEETATGAFTARQDGVVAGLPVAAVVCGLLGLETTLHAADGDRVAAGRVLMTVTGPTRAVLRAERVALNLLTHLSGVATLTRRWADAVEGTGARVRDTRKTLPGLRALQKYAVRCGGGVNHRMGLHDAALIKDNHVAAAGSVTKAYQAVRDMYPSLHVQVECDTLAQVAEALAVGVTSILLDNMSTAELAEAVRLVAGRAELEASGGLALEQARDVAVTGVDYLAVGALTHSAPAFDIGLDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZAJ4</accession>
    <name>A0A1H5ZAJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="7" type="ORF">SAMN04489712_104438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33060">
        <property type="protein sequence ID" value="SEG33060"/>
        <property type="gene ID" value="SAMN04489712_104438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG33060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="196" mass="20809" checksum="72B46AB682611D2D" modified="2017-01-18" version="1">MPKPTKGARLGGSPAHERLILANLATSLFEHGRITTTEAKARRVRPFAEKLITKAKKGDLHNRRLVAEVIRDKSVVHSLFTEIAPAFAERPGGYTRITKIGPRRGDNAPMAVIELVAEPLSTATVGATETKGEGAEKLDLTKADAEAAEGAEEQATEAKAADAEAKGDEDAEAKGDEDAEAKGDEDAKDAKDEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZF69</accession>
    <name>A0A1H5ZF69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate--glycerone phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.121</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_104513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18381"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.7.1.121"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.121" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34730">
        <property type="protein sequence ID" value="SEG34730"/>
        <property type="gene ID" value="SAMN04489712_104513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047324">
        <property type="term" value="F:phosphoenolpyruvate-glycerone phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039643">
        <property type="entry name" value="DhaM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012844">
        <property type="entry name" value="DhaM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38594">
        <property type="entry name" value="PTHR38594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02364">
        <property type="entry name" value="dha_pts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="5">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG34730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="12684" checksum="8C5562C687803C87" modified="2017-01-18" version="1">MANVGLVVVSHSRRLAEGVCELAREMGVHKVRVEAAGGDVDGGLGTSIELVENAVRAADDGAGVVLLADLGSSVLTARTFVEDADTSVLLADAPLVEGAVAAASAAAAGADLAAVVAAAEDAYDQRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZF72</accession>
    <name>A0A1H5ZF72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34375">
        <property type="protein sequence ID" value="SEG34375"/>
        <property type="gene ID" value="SAMN04489712_104496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG34375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="380" mass="38408" checksum="7E5031667EC48565" modified="2017-01-18" version="1">MELDHEFTVPVPVDQAWSVLLDVERVALCMPGATLDSVDGEDYVGRLKVRLGAMTITYRGTARIVEADEAARALTIEGSGKEARGSGTASATIRARMSQEGDVTRVVVHTKLNVTGRPAQFGRNILAEVGAKLIARFATALAEELKEAPAPAERSAAAEAPTSAKATSEAPAKAASTTPAAPEAPAEAAPETSAKAAPGATPETPTEAAPAAPAKAPAEAASEAPAEAAPEGAAEEGVGAATGGPGAGDTAVRGRETVTEGDNLAAAAGSAEAAQEVVDQQRAAATAAESADATAAPAVGEVVDQQGAADAAAVAGPEPADAGHPAVAYRRERRADDAIDILEVAGPSVAKRLVPTVLSALAALLTLRYLFRRRRGRHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A0B8</accession>
    <name>A0A1H6A0B8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41860">
        <property type="protein sequence ID" value="SEG41860"/>
        <property type="gene ID" value="SAMN04489712_105104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG41860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="34539" checksum="D61306A5D7B3700C" modified="2017-01-18" version="1">MNLVGHLECFVAVAEELHFGHAAERLGMAQPPLSQRIQRLERELGIRLFDRSSRHVELTPPGRLLLEEARDILARVDRIYSLAARARLGAVGTVRAGLPAGLGGPVLAALIEGFREHCPDLRLELRELGSAEQGRALTEGALDVGVLRHPCDVRDLELGPMLLQPVGAVLPAGSPHGARAALHPADLAGREVVLFPREDAPGAHDELLAACRRHGLDPSAVHEARHPQFALGLVLAGTAVALTPRTEDAEGAVWRPFAGDPLALRTSCAWPRGRRDPVLERAVEHFTSIATGVLRRHAGMVPLDRSTARRVVARPSSGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A6Q5</accession>
    <name>A0A1H6A6Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MinD-like ATPase involved in chromosome partitioning or flagellar assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44020">
        <property type="protein sequence ID" value="SEG44020"/>
        <property type="gene ID" value="SAMN04489712_105228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025608">
        <property type="entry name" value="TcpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12648">
        <property type="entry name" value="TcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG44020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1352" mass="140999" checksum="01A5DFBC44904A25" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9R5</accession>
    <name>A0A1H6A9R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44944">
        <property type="protein sequence ID" value="SEG44944"/>
        <property type="gene ID" value="SAMN04489712_105279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="172" mass="20095" checksum="B1CF57C2CEBFECD4" modified="2017-01-18" version="1">MEVHVRHSDLRELGRDFRAAGRRDLSRDMLKEMRGSVKPIVPQLRSALRGSPSRTGDQRTESARQARPRGLRDAMARGVQTKASLAGPRVGVRLRIDPRHFPDKQKSLPKYREGVLPRWRSPNWGRDEWKQQQSHPVFFPTIRPHIPRVQRDLRRIVDEYVDRVARETDTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWM6</accession>
    <name>A0A1H6AWM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53039">
        <property type="protein sequence ID" value="SEG53039"/>
        <property type="gene ID" value="SAMN04489712_10669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293125" evidence="1">
        <location>
            <begin position="34"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="415" mass="43871" checksum="2E5FB5A1C0D57B1B" modified="2017-01-18" version="1">MSRISGRLRIFGAVAVGIMAMGAAGAITTPASAATTVYSEDFSSGLGTFTASGSVTTGTYGARLSGSLLSDPSMTSAPIDLDGYSGVTVSYTRAAAGLDLGEAFTVAYSVDGGSFITLESARTATGAASFNLPASVDGRDLRLRFSLDANSALETLTVDDVLVEAAGGEDPDPPTGSLPPVADVTKPGPYAVTINRSAGPRGSGWLVYPTNAGQNGVDHPIFVWGPGAGSAPADYEDMLRQWASHGFVVYSEVSSSSGDYMVNALNWLQTQNSTPSSPLYQDLDTAEVAFGGHSRGSIGTFDVADEPRLTTTVHVAGGSFDGNGPSNLRKPTLYIGGDEDFATSNMERDYTNTRVPVWFNILNNTDHIYATRNGQHIITAWLRWHLADEEFRRTENFLSRTCTFCNLGAVTYKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B1H8</accession>
    <name>A0A1H6B1H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54711">
        <property type="protein sequence ID" value="SEG54711"/>
        <property type="gene ID" value="SAMN04489712_106174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG54711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="220" mass="23588" checksum="81BB15FFC4F8C5A3" modified="2017-01-18" version="1">MRTVLRGLAELTVTAGLILALFVGYLAWGTGEYTRRQQGDLRDDLERQWSADRVRRLADVQPAGSGTAPAPAAGQALAILRVPRFGASYRYAVVEGVSVADLRKGPGHYPGTAGPGEIGNMVIAGHRTTYGGPFERNDELARGDEILVDTATTTYVYRVTGRTVVRPSGIEVTAPVPGRPGRKPRKAMLTLTTCHPKFSAAYRLVVFAELAGRRARAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3E1</accession>
    <name>A0A1H6B3E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenylpropionate dioxygenase, large terminal subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_106187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54895">
        <property type="protein sequence ID" value="SEG54895"/>
        <property type="gene ID" value="SAMN04489712_106187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044043">
        <property type="entry name" value="VanA_C_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19112">
        <property type="entry name" value="VanA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG54895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="449" mass="49461" checksum="0C9D027CF1ECF955" modified="2017-01-18" version="1">MLKNFWYAVEFAHAVTRAPKKVTCLGQDFVLYRKRDGSVVCLSDLCVHRGAALSAGTLVEDRIACPYHGWEYGPDGACTKIPANPEGRGIPKKARVDSYPVLEKYGMVWAFLGDLPEEERPPIPHFPEHEDPAFRAVYVEMVIDANYERTFENVVDAAHTPFVHGTRFGNPDKPQIPDYEITQDEWSAAADILLSPPPAKGLWKRLYKERPEEVMVTNGWYLPNIVKLHVRLPFGDMILYDHNVPLDRHRTLVKIVGYRNFFTGKWADPDARKRIRSILLQDKPVVESQRPELLPYDLPDELHLRSDSLQVAYRRRRQQLMAEGWWVGDDETAAGGPRGSATVIPSPARRENPELARAWQHKARGGDPVPVKRAIDDTGPAESTVDDTGSAGKTTGGADSAKSATGGTEPAGKTTGADPAGKTAGGGPAESAARDAVLAEKTTTEGGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3I3</accession>
    <name>A0A1H6B3I3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_106229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55401">
        <property type="protein sequence ID" value="SEG55401"/>
        <property type="gene ID" value="SAMN04489712_106229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="732"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG55401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="769" mass="84299" checksum="AE6EFB8F6D1371AA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B4X1</accession>
    <name>A0A1H6B4X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55660">
        <property type="protein sequence ID" value="SEG55660"/>
        <property type="gene ID" value="SAMN04489712_106248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG55660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="568" mass="61004" checksum="6625D9CA3A7A8273" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6C5</accession>
    <name>A0A1H6B6C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56162">
        <property type="protein sequence ID" value="SEG56162"/>
        <property type="gene ID" value="SAMN04489712_106289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="122"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="30260" checksum="F82C66D12344D608" modified="2017-01-18" version="1">MEQGHEVVLTGGDVTEGVVRAGDTVRRPLRAHSPAVHGLLGHLERVGFEGAPRFLGIDELGREVLTWMPGETPGRPMREYAATEEALRGVARLLRRFHDAVSMYEAPPDAPWDVAFTTNVDDPPELIGHCDVTPDNVVFRDGVPYGLIDFDLARPTTRLFDVVNTLRTWAPLADPADRDEVFARLDADAVGRRIRRFCDAYGLGREERRRVLPVARLRFERSYLAMRARAERLGGGWERMWRGGIGVRIRRGQDWLEQSWDVLDARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6H4</accession>
    <name>A0A1H6B6H4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="7" type="ORF">SAMN04489712_106287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56134">
        <property type="protein sequence ID" value="SEG56134"/>
        <property type="gene ID" value="SAMN04489712_106287"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="257"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG56134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="501" mass="52922" checksum="25455CC6F5365F52" modified="2017-01-18" version="1">MSGALLVAGTTSDAGKSVLTAGLCRWLVRQGVKVAPFKAQNMSLNSMVTLDGAEIGRAQVTQAQAARIEPTAHMNPVLLKPGSDRRSQVVVLGRPVADVDALEYREHKDRLRDVALASLERLRAEYDVVICEGAGSPAEINLRAGDIANMGLARAAGLPVLVVGDIDRGGVFAALYGTVGLLEPADQALIAGFVINKFRGAQELLAPGLQQLQRLTGRPTYGVLPWLDGLQLDVEDSLGLDVPLPAAPAPHGAETLRVAVVRLPRISNFTDIDALTCEPGVSVRYATTPGELADADLVVLPGSRATVSDLGWLRARGLADQIVRRAAAGRPVLGICGGYQMLAAEIVDEVESAAGRVEGLGLLPVRVEFAADKTLRRPSGAAYGHDVRAYEIHHGIATVDEGAEPFLDGCRAGAVWGTTWHGALENDGFRRAFLREVADLAGRDFTPAPDVSFGALREARLDALGDMVERHLDTAALWRLIERGAPPGLPVVPPAGADLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6I6</accession>
    <name>A0A1H6B6I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56222">
        <property type="protein sequence ID" value="SEG56222"/>
        <property type="gene ID" value="SAMN04489712_106295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG56222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7264" checksum="21A35F6EBCAA8CB1" modified="2017-01-18" version="1">MTVTTSSADYAAEPPLGGSVSLDELARRKSVRPVQSADDLAQDGVFDSDEELDAFLEHVAAERRADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B7M4</accession>
    <name>A0A1H6B7M4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oligoribonuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orn</name>
        <name evidence="3" type="ORF">SAMN04489712_106341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">3'-to-5' exoribonuclease specific for small oligoribonucleotides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56853">
        <property type="protein sequence ID" value="SEG56853"/>
        <property type="gene ID" value="SAMN04489712_106341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00045">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG56853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="22482" checksum="3C67C1F4DBB12FDC" modified="2017-01-18" version="1">MNDLLVWADCEMTGLDLRRDALVEIAVLVTDSELNILDKGVDVVIKPPEEAVAQMSKVVRDMHTTSGLLAALPNGVSVGEAEDMVLSYLRTHVRDPKKAPLCGNSIATDRSFIARDMPALDAHLHYRMVDVSSIKELARRWYPRVYFASPQKTGGHRALADITESIRELRYYRQAIFVPQPGPDSDTARSLAAEVVAAATRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BK94</accession>
    <name>A0A1H6BK94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate starvation-inducible protein PhoH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60626">
        <property type="protein sequence ID" value="SEG60626"/>
        <property type="gene ID" value="SAMN04489712_107144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="124"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG60626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="38509" checksum="334C6DB0408A3A2E" modified="2017-01-18" version="1">MVEITHAGARRRTGGSRSQVKIVVPDDHSMVSLLGSRDELLHVIEHAFHSDIHVRGNEITVTGPEDESELVSRLFAELITLLKGGTQLTPDAVERSLAMLRAETAESPAEVLNLDILSGRGRTIRPKTLNQKRYVDAIDKHTVVFGIGPAGTGKTYLAMAKAVKALQDKKVNRIILTRPAVEAGERLGFLPGTLYEKIDPYLRPLYDALHDMVDPDSIPRLMSAGTIEVAPLAYMRGRTLNDSFIILDEAQNTSPEQMKMFLTRLGFGSKVVVTGDVTQVDLPGGQQSGLRVVQEILEGIDDIHFCRLTSHDVVRHKLVTQIVDAYDRFDRQAPVEVNQARSGPRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BU88</accession>
    <name>A0A1H6BU88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64291">
        <property type="protein sequence ID" value="SEG64291"/>
        <property type="gene ID" value="SAMN04489712_10811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="178" mass="17410" checksum="2E49F05A6B4218F5" modified="2017-01-18" version="1">MSGGSMADPDGTVPPDGAPGPGSAPRAGGFEPSVSADGTWRPINAGAAPSPVPAPMTPPTATPSPAEPTTEPAAAAGPPPAEPASPPEPVPPATQTLPAAPFPAVPPPDPTGDERVDAALGGLAGLAGAPVHGHVEIFEDVHRRLQDILTSVDQEPAGPPVPRPPGPGIVPPRHGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BY34</accession>
    <name>A0A1H6BY34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-6-phosphate dehydrogenase assembly protein OpcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65076">
        <property type="protein sequence ID" value="SEG65076"/>
        <property type="gene ID" value="SAMN04489712_10875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00534">
        <property type="entry name" value="OpcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="37458" checksum="353187965EF70823" modified="2017-01-18" version="1">MNIDLADTSTRRIEKSLRQARHLMGGPAIGMVLTLVIVTDESAQYDAVRAANEAARENPCRVLTVISRDARGSSSRLDAEIRMGETGPGETVLLRMYGPLAEHADSVVLPLLVPDAPVVTWWPGQAPDRPGADPLGVLAQRRVTDSYAAQDRLGTLARLAQGYQPGDTDFAWTRLTPWRTLLAATLDQEHAEIVGGRVDGEPDSPSAELLASWLAIRLGVPVSRRSSQGPGLTAVTLNTAEGDITITRPDGRVATLSRPGQPDRQVALHRRPMSELLAEELRRLDPDEVYHEAAVRYAKDLEAAQRSSESAEESAQRSPKPAAESTQRPRKPAGAAASRSRKPAGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2T1</accession>
    <name>A0A1H6C2T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Large conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_108266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67232">
        <property type="protein sequence ID" value="SEG67232"/>
        <property type="gene ID" value="SAMN04489712_108266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG67232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="160" mass="17497" checksum="7FAA89A2487F024C" modified="2017-01-18" version="1">MRIHPVPRRHELVELRKSGLETLGGFRSFLIRGNLVDLAVAFVVGAAFAGLVKDFVTAFIAPLLALLGGEPDFTRLSFTIAGTRFPYGVFLTSATAFFITALIVYFLVVLPTTKLIARLHRGERATERDCPECLSAIPVAARRCRYCTCEVVAATEAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C3Y4</accession>
    <name>A0A1H6C3Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Creatinine amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_108251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67076">
        <property type="protein sequence ID" value="SEG67076"/>
        <property type="gene ID" value="SAMN04489712_108251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG67076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="26066" checksum="7A65AC14D570827B" modified="2017-01-18" version="1">MDDSAWFLPASTADQVRDRRAGVALLPVGSFEQHGPFLPLATDTVIACTIAAALAAAHPVLRLPPVTISCSHEHEAWPGTVSISAATLHALVGDVAGSLRRSGVTRLVLVNGHGGNYVLGNVVQEANAAAQAAGDGNVMALFPGPEDWEAAQAAAGVQTPAWSDMHAGELETSLLLHAHPQLVRPGYAAGDHVHDDRRHLLTLGMAAYTRSGVIGRPSLASARKGKDVLDHLVRAFADYLAVLGGPDDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9P2</accession>
    <name>A0A1H6C9P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent peptidase ImmA, M78 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69622">
        <property type="protein sequence ID" value="SEG69622"/>
        <property type="gene ID" value="SAMN04489712_109102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG69622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="369" mass="40244" checksum="92AE648667BC0208" modified="2017-01-18" version="1">MSDHEDGRPGGRADQARLLFDSQRLTLARRLRGLRKNQLAEAIGTTPTAIGQYEAGVHRPSAITLSRLAFALGVPVEFFHAGHGRAVLDSAHAHFRSLRSTTQIERDQALAYGRIAGDIVAALEAVVEFPPVDVPEYPVHPDEMAGPGPVRAARAARAALAAAPGPIAHVVRLLESRGIVVIVLPPSTERVDAFSVSAHPRPMVMFNPAKGDYWRNRFDGAHELGHLVMHADAEPGSKVVEDQANRFAAEFLMPEEDIADALPRTADWTRLAALKAEWGVSMAALLYRARTLKVMKEVTYRNAMSTLSARGWRRQEPGPPRPLETPTMLVRAMEVAAIAGTDRDHLATTARVTRADLDLLVPPRTRPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9P7</accession>
    <name>A0A1H6C9P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69632">
        <property type="protein sequence ID" value="SEG69632"/>
        <property type="gene ID" value="SAMN04489712_109103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="57"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="452"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG69632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="540" mass="57613" checksum="A5A7561655E92931" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAH3</accession>
    <name>A0A1H6CAH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter substrate-binding protein, PAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_109126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69918">
        <property type="protein sequence ID" value="SEG69918"/>
        <property type="gene ID" value="SAMN04489712_109126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294669" evidence="4">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="35"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG69918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="29130" checksum="4E56CF4427C96D8A" modified="2017-01-18" version="1">MRSPVVSFALVVLAVLTCGACAGPGGGSSILDKGTVVVGVRPDLPGLGLRRPDGTFEGFEVDVARDLAVRLGWKVRFVAALAADREPLLLSGRADLMFGTFSVTPERKLKVAFAGPYHVSYQDILVRSGDRRINGVRDLKGRRICAVEGANAAERVVRERGVPAVPVPAPHYDRCMAMLRTGEVEAITTNDVILAGLIARERGAGLRLVGAGFGEQRTGIGMRRGDVAGCEALNRAITQMYQDGTARRLLLRWFDGTGLELGTIAVPQFEGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDD1</accession>
    <name>A0A1H6CDD1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_109211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70843">
        <property type="protein sequence ID" value="SEG70843"/>
        <property type="gene ID" value="SAMN04489712_109211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="6">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG70843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="13206" checksum="B8983B3D48E8A337" modified="2017-01-18" version="1">MDKSRRTAAAGQAWQIYRETQRPGAPGLWQRARAVPGMIRDAARGDYKGLGHGKLALLLFGVVYLLSPLDAIPEFLPFIGVADDLGVALWMLATLVSNAGDYVDWRQGRPGVVTGEVITDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CE30</accession>
    <name>A0A1H6CE30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein implicated in regulation of membrane protease activity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71093">
        <property type="protein sequence ID" value="SEG71093"/>
        <property type="gene ID" value="SAMN04489712_109240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="52"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG71093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="14719" checksum="9024242B8E5E529D" modified="2017-01-18" version="1">MEAWIVWLIVAAALGTAELFTLTLALGLLAVAAVAAGVTGALGLPLAVQVLVFVATSVAGLGVVRPIAARHVRQPPPLRSGVAALIGKQALTLTEVSKRGGRVRIGGEEWSARPYDPDLVIPADVDVDVLGIEGAVALVYPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEJ8</accession>
    <name>A0A1H6CEJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71217">
        <property type="protein sequence ID" value="SEG71217"/>
        <property type="gene ID" value="SAMN04489712_109251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="15125" checksum="A185943C62581F3F" modified="2017-01-18" version="1">MAGVPDSAITGAPHGVAGVVDRTRTAARHGVLGVALRVGAMTVAAVAVAWLHRVNDPGVLCPMRALTGIPCPLCGGTTVFIELGSGHPVRAAAANPAVLVAAVALATAPLGPGGRWWALRPKTRAWMLGAALAASELWQLARFDLLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEN7</accession>
    <name>A0A1H6CEN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71424">
        <property type="protein sequence ID" value="SEG71424"/>
        <property type="gene ID" value="SAMN04489712_109269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="24"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG71424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="338" mass="35277" checksum="B5A9538A2BADB1A8" modified="2017-01-18" version="1">MKTDERQHAAGQTVRALVQRSHRGPKDLTLTTDQRRPTPGAGEYLIRVGAAGVNFADVMQSHGTYRGGPRAPYVAGFEAAGEIMGAGPEIESPLQLGTRVVGTGPGAFAQYMTMPAADVLPVPSGWSDAEALGLVLNWATALAALKPLGEIKAGDVVLVHAAAGGVGQAAVRLARHYGARVIATASPGKHATVRALGADEVLDGRRPDLAEEITRLTGGVDLVLESVGRATFKASLSVTKPFTGRVVVFGAASGDAGLSTHDLVFTHRVQVKGLHIGALAAMAPSIYRWLLVEIEALIAQGVYPPGTPHVHPLAEGPAVLRQLEAGQTRGKHALDPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CHM3</accession>
    <name>A0A1H6CHM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72469">
        <property type="protein sequence ID" value="SEG72469"/>
        <property type="gene ID" value="SAMN04489712_1103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG72469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="11553" checksum="CE5E6B266F5F2EE8" modified="2017-01-18" version="1">MRYAVSRPYIVPESLAELAGPTSGVVKLPAHLDWSEQHVYDLGDPAQAGLMYERVIREASSSRDLAAYLNAGMLDRLWNRLYLPPQVRRLWESRFPGLVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CK01</accession>
    <name>A0A1H6CK01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73270">
        <property type="protein sequence ID" value="SEG73270"/>
        <property type="gene ID" value="SAMN04489712_11090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG73270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="233" mass="25947" checksum="4DCABA16F20B4532" modified="2017-01-18" version="1">MNAKVDGERTASPARGRRGQGRRRLSVDERRDELIDAALRLFSTRPPDEVSIDDVAVAAGASRALVYHYFGGKYELYVAALRSAAGRLSVLLEPPTEGRPLERLRLSLSRYFDFVESHASGYSALLRGGPADRSGEVGEIINGIRSLLLDRILHALDIPEPGPVLRITLRSWMACVETAAMDWLERRDLARDELERLLVDQIVVLLHAAGRHDPRISALFDRLTQEELGQAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNQ1</accession>
    <name>A0A1H6CNQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_110249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74619">
        <property type="protein sequence ID" value="SEG74619"/>
        <property type="gene ID" value="SAMN04489712_110249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="52"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG74619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="312" mass="32549" checksum="3ED0EDC65187E586" modified="2017-01-18" version="1" fragment="single">MSNPTPNTPVPDSPSGSPMPASPRSGPRSGAPRLAVRKTYKLFIAGAFPRSESGRSYVVNDAKGAFLAYAAHASRKDARDAVTAARKAFAGWAGRAAYNRGQILYRIAEMLEGRRAQFIDELRAAGLAKTAAAGEVEAAIDRWVWYAGWADKLTTVAGSANPISGPFFNVSTPEPTGVVAVIAPDSPLLGLVSVLAPVIVTGNTCVVIASEPAPLPAITLAEVLATSDLPGGVVNILTGHREELAPILASHMDVNALDLAGTPTDQAGPLQEAAAGNLKRVLPPTGDEWTTDPATTRMTAFLETKTVWHPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSI7</accession>
    <name>A0A1H6CSI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75999">
        <property type="protein sequence ID" value="SEG75999"/>
        <property type="gene ID" value="SAMN04489712_111107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="184" mass="19969" checksum="8B87E7476A3D8A0A" modified="2017-01-18" version="1">MSLSAEHLDAAATLALSDQVEPLYRSCFSEPPWNETEEELAACGLRLSRAVCRPGFRALAVRDTDGTLLALCYGWPTPPNLTGCDVYARLTAAIGSTAAHDLTRGAFEIAELMVAPRARGRGIGGRLLTTITAPWPRAWLSTLLDSPAARLYQRHGWRRACPLPHPGSDKTWAVFTWTASPNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT91</accession>
    <name>A0A1H6CT91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76259">
        <property type="protein sequence ID" value="SEG76259"/>
        <property type="gene ID" value="SAMN04489712_111142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="14881" checksum="313217F73C6A605A" modified="2017-01-18" version="1">MPDSMAASAVLAQAEALQDKVRHRSLWYARYLRCYGAAAFVMTLMLCWGKGWVVGSVALWGVVIAALSVYAARQPVARRGFGRRHRLIIGCWAVLYAAVLVPGTIWFQGEPVWWLPGAVLVSLPAFIGAHLEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTV3</accession>
    <name>A0A1H6CTV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76237">
        <property type="protein sequence ID" value="SEG76237"/>
        <property type="gene ID" value="SAMN04489712_111139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="131" mass="14470" checksum="2C23B0DFB063AD8F" modified="2017-01-18" version="1">MSKRPVNVGEWPEPVPAGPAARLRRELARGTTELAVLSVLASQRRYGYELMKRLGQAGGGVLEIKEGTLYPLLHRLEDAGLITAAWEAEGRSRPRKYYSITPEGRAHLAVLRAEWAALVEAMGHLLDEEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUA9</accession>
    <name>A0A1H6CUA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-related sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76387">
        <property type="protein sequence ID" value="SEG76387"/>
        <property type="gene ID" value="SAMN04489712_111157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="111" mass="11822" checksum="A7B36C5C564B4082" modified="2017-01-18" version="1">MFFGEDVPSAKVADVPQDAYLLDVREQDEWDAGHAPAAVHIPMGQLGDRAGEIPQDREVYVICRSGVRSAQVTVALNNAGWTARNVDGGMQEWAGAGRPMVAESGPGPYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV48</accession>
    <name>A0A1H6CV48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76844">
        <property type="protein sequence ID" value="SEG76844"/>
        <property type="gene ID" value="SAMN04489712_111214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="24914" checksum="2C47C98D2F21ACDD" modified="2017-01-18" version="1">MVKEQRPKRRYQSRVRQDGARRTRQAIVAAAGELFVRHGYAATSLADIAAAAGVARPTVSAAFGSKPALLKQVLDQALAGDDEPVPVADRPWFRPVWDATTPAGVLDAYAGVCTIINGRAGPIFETVRRAADATPEVADLWDTLLRNRRAGARMVAEHARSLGPLREDPDIERAVDVLWFFNDPAHHNALVRQQGWPEDAYRRWLSDMMRHALLPSQAPRDEPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZH9</accession>
    <name>A0A1H6CZH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR HTH family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78237">
        <property type="protein sequence ID" value="SEG78237"/>
        <property type="gene ID" value="SAMN04489712_11251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="119" mass="12817" checksum="5DB61CA83F3FE5B1" modified="2017-01-18" version="1">MSQPLPGAVYALVRTGPARMDLETFARAGGAHPELVRRLVRLGLLDPEPGPSGEPWFPPAQLTALARIQRLRAGCALNYAALGLVIDLLDRIAALEEALRRSSRQSPPDMGGRPWTPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZL4</accession>
    <name>A0A1H6CZL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78277">
        <property type="protein sequence ID" value="SEG78277"/>
        <property type="gene ID" value="SAMN04489712_11256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="850"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="915"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG78277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="949" mass="99302" checksum="9DB8B3D690EDFE63" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1X9</accession>
    <name>A0A1H6D1X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_112141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78913">
        <property type="protein sequence ID" value="SEG78913"/>
        <property type="gene ID" value="SAMN04489712_112141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295420" evidence="3">
        <location>
            <begin position="29"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="4">
        <location>
            <begin position="173"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG78913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="436" mass="45622" checksum="5C85173712E40DA7" modified="2017-01-18" version="1">MVAAELALFLVALAAGFLQLLWSPPAPARVAAVAASACWAALLLPARRRWPVAALAATAPVLAGGNVGAMAVLPIVSYATARRVHPARRLWAVVPATAAAGLLLALAVERNAPYGLEAALAGNAISVAVLLVFPALAGALRGQRRPRVRLLRERNAYLERAQGLAADKARMKERARIAAEMHDMLGHRLSLISMHAGALELTAARTAPELSGQAELLRTSASTAMSELRGILGVLRDATDEAPEAERSGTRADIADLVAESRKAGVDVELVWPGPDLAGADPRTRHAVHRVVREGLTNVHKHAPAARTRVEVTVERDRVRVRVTNGPVPGTRPRSPGTRQGLVGLEERVALLQGALTAGPTPEGGFQIAADLPAHPSVPADPPVPREEPEPREVPPPLDAEVLTLPRVLGAGCLGALAAVPVVTGLAVLIVLSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3T8</accession>
    <name>A0A1H6D3T8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4395 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79286">
        <property type="protein sequence ID" value="SEG79286"/>
        <property type="gene ID" value="SAMN04489712_112194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025508">
        <property type="entry name" value="DUF4395"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14340">
        <property type="entry name" value="DUF4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4395" evidence="2">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG79286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15206" checksum="D76A878F71EA3956" modified="2017-01-18" version="1">MQVDPRGQRMAAGITTVILVIVLVTGSWELLAAQAVVFAVGALAGLRYAPYGLIYQALVRPRIGPPAELEAAAPPRFAQGVGLVFAVVGTAGYALGTEWLGIGATAFALGAAFLNAAFGFCLGCEMYLLIRRVIPLNRSEREVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAE8</accession>
    <name>A0A1H6DAE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81476">
        <property type="protein sequence ID" value="SEG81476"/>
        <property type="gene ID" value="SAMN04489712_11465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="7090" checksum="1BF4DFE91A1CF8C1" modified="2017-01-18" version="1">MVDELAAGGAVLRPAVHQVDDLLAEPTIKNLYIGDHPTYWMTPGVPHDAYLGEFLMRTKAVIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGT6</accession>
    <name>A0A1H6DGT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase, FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84459">
        <property type="protein sequence ID" value="SEG84459"/>
        <property type="gene ID" value="SAMN04489712_1177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="41451" checksum="FF14CA3B238398FA" modified="2017-01-18" version="1">MKHRIVVLGAGYAGAYVAGNLARRLSPADTEITVVNAEPDFVERLRLHQLAAGREIEAPKLADVFAGTGIRLRLARVTAVDPERQVVAVADADGGGGELGYDTLLYALGSHGDDRGVPGVAEHAFDIAARPSALRLRERLDSLGGRGEGGSVLVVGDGLTGIETATEIAESRPGLSVTLVARGELGARLSAGARNHLRRACDRLGITVLEHTSVEAVEATRVLCADGTALASDATVWTAGFTVSPIAAAGGLEVTENGQVVVDRTMRSVSHPNVYAAGDSAYAIGDNGLPLPMSCASAGFTGLQATDAIVGRLTGRKIANTKLAYPGNHISLGRRDGILQLVDGEAQAKPKYVGGRKAARVKAGILRMSLWSISHPTFGLPKRKCRLAAVPDASAVKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DH65</accession>
    <name>A0A1H6DH65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84502">
        <property type="protein sequence ID" value="SEG84502"/>
        <property type="gene ID" value="SAMN04489712_11715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="244" mass="25866" checksum="2C2D2244ED79EC87" modified="2017-01-18" version="1">MHADLRGKTALVTGAARGLGAAVTRRLGAAGAAVWAADIREDRLRDLCRELRDDGVQARPLVLDIRDAGQVAEAITGVYNGAGSVDVLVNNAAVDVTKPIEHLTAQEAGWVIGTNLLGPVHLCLETYRRMIKQGGGHIVNILSTAANRTWTEAGPYAASKTGLRAFTHTLFQEAQRDCPGIGVTGIIAGGMETPFITERFPDADTSRLQDPAIVADTVLYVLSVPAGSVIPELVVIPRNESSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHZ7</accession>
    <name>A0A1H6DHZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase, sigma subunit, ECF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_1176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84453">
        <property type="protein sequence ID" value="SEG84453"/>
        <property type="gene ID" value="SAMN04489712_1176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG84453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="317" mass="34939" checksum="7B43E6870327DFCF" modified="2017-01-18" version="1">MNSTATDRFDTDRFEASRNRLASLAYRLLGSAADAEDAVQDAFLHWQAADRQRIKVPEAWLTKVVTNLCLDRLRSAQARRERAVGAWLPEPLLDGDPMLGPADTFEQRESVSLAVLTLMERLSPLERAVYLLREAFSYSHAEIAEILDITESASQQHLHRARRRITAARRRGGEVDPASARRIVEEFFAAAFSGRTERLVALLTDDATAISDGAGLAGTLLRYDTPQRIATVVRAGFKPTPAKRRFAGGTPAIHYALVNGAPAILFVLGDQVLGAVTFDIANGKIATVRGIAAPTRLARLAEAWRRYEPDTPLIPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DII9</accession>
    <name>A0A1H6DII9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_117110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85002">
        <property type="protein sequence ID" value="SEG85002"/>
        <property type="gene ID" value="SAMN04489712_117110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="105" mass="10471" checksum="642E22B19BD15778" modified="2017-01-18" version="1">MNSTATTLRPGDQLASTVCTTRVVVVRAPDGERPQLACGGSPMVPAASAQPSQSSAADAATLIGKRYVNAAGTLELLCISSGAGELSCDGVPMTLKAAKPLPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIK3</accession>
    <name>A0A1H6DIK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84663">
        <property type="protein sequence ID" value="SEG84663"/>
        <property type="gene ID" value="SAMN04489712_11745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="93" mass="9771" checksum="F3B403B77A570571" modified="2017-01-18" version="1">MSSGRAGEVIDMVTGDVTGDMNGGVLAAHPLISAVPFFVPTFVVVAVIAVVIWRDRRHDDHGDHGDHDDEHGDDHDGGLRSGDRGTDGADGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIP2</accession>
    <name>A0A1H6DIP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_117127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85061">
        <property type="protein sequence ID" value="SEG85061"/>
        <property type="gene ID" value="SAMN04489712_117127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="379"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="468" mass="50179" checksum="DD475B1BB3B8CE85" modified="2017-01-18" version="1">MSEPIALVFEEREYSPAQLEALADGLAGTLARRGVRAGDRVALMSSNRPEFVVVVRAIWRLGAAVVLFSPAWKRTEAEHAMAVAAPTHAVGDHPVLAELMPMLHLDEPIDPGDGGPPPAPDPGSDAVLVFSSGTTGLPKAVRHTHASFGAAVRHWRDALELTDRDRIQITTPPSHILGLLNIVTALETGAWLRLHRRFDLDRMLHHIEADRITVEMAVAPIALAMAAHPTLESYDLSSLRYIMWGATPVTASVAETVTRRTGVGWVPAYGASELPVITCNPVKGARLDSAGRAVPGVRLRVVSLETGQPVGPGETGEIQARAESLMAGYLPAEATAQALCDGWYRTGDVGHIDADGWVRLTDRSKEMIKVRGFQVAPAEIEAVLHGHPAVADCAVFGVPDPADGEAIVAAVTPHDTVDPEELIALVGDRLASYKRPSRVVLVPEIPRLPSGKVLRRVLKERHGRASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIZ1</accession>
    <name>A0A1H6DIZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_117155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85172">
        <property type="protein sequence ID" value="SEG85172"/>
        <property type="gene ID" value="SAMN04489712_117155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="15256" checksum="070510782277AF31" modified="2017-01-18" version="1">MTSVEDVIEIQQLLAKYAVSITKGDIDALLEVFTPDGTYSAFGEEYPLDEFPGLVAAAPKGLFLVSTPLLDLRGDEGTGVQNLCFVDHATHDMRIGYYNDTYRRTADGWRLHTRAMTFIRRNGEHDSGRPHSHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL46</accession>
    <name>A0A1H6DL46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein, DUF849 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_118112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85938">
        <property type="protein sequence ID" value="SEG85938"/>
        <property type="gene ID" value="SAMN04489712_118112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="29201" checksum="75DD26602E5ED659" modified="2017-01-18" version="1">MGATTLITVAPTGAESAKADVPQLPVTLDELVQAAKDCEAAEAAVIHVHVRDERARPTLDPPRVRDTVQALRENTGMVIQLSTGGAVTDSYEDRLRVLEAGPDACSLTCGTVNFGDDVFMNPWPFMTELYQRTQELRIVPEFELFDLGHVATLHRLLDECGEPHGGHVHCDLVMGVPGGMPGDARTLVAAVEALPAGATWSATGIGRTTLPVMFAALSAGGHLRVGMEDTLTYAKGRPVTSNAILVERAAALARFAQRPPMTAEQARAFLGVGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMA8</accession>
    <name>A0A1H6DMA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nickel uptake regulator, Fur family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_118116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85953">
        <property type="protein sequence ID" value="SEG85953"/>
        <property type="gene ID" value="SAMN04489712_118116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="15275" checksum="FC27EC5964F778EC" modified="2017-01-18" version="1">MADTWQEELRAHGYRVTPQRQLVLEAVTSLEHGTPEEICTEVQRTARGVNISTVYRTLELLEELGLVKHTHLGHGPPTYHLAAEAEHVHLVCRECGAVNDVTPRVADGLVEVLARDHGFQTDVHHLTVYGRCRDCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQS3</accession>
    <name>A0A1H6DQS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87023">
        <property type="protein sequence ID" value="SEG87023"/>
        <property type="gene ID" value="SAMN04489712_12054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="78"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG87023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="36416" checksum="CC2F36B31783A99F" modified="2017-01-18" version="1">MTDEDDRRDVRSEAEGAVPNEKQAVTPGEDAAEDRANGSAPGAGGAAGDMGASRDEDGSDAPAEESGKDGKQGSFWKELPILIGVALVLALVIKAFAVQAFYIPSASMENTLQIGDRVLVNKIVYHTRDVRRGDIVVFNGLDSWDPEVQVAEPTNPISKAFHWIGGAFGVVPGEKDYIKRVIGTPGDHVKCCDSQGRMTVNGAPLDERSYLFTDPVTGERNKPSNEPFDVTVQPGNLWVMGDHREVSYDSRQHRGDPGGGAIPENRVIGRAFVIVWPVNRIGTLPIPKTFEQPALNAAGALLPATPFALGLAGAIPITLLNRRLRLRLRRTRRRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT91</accession>
    <name>A0A1H6DT91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88450">
        <property type="protein sequence ID" value="SEG88450"/>
        <property type="gene ID" value="SAMN04489712_1225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="795"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="873" mass="94461" checksum="F014C68E5B34299E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTB6</accession>
    <name>A0A1H6DTB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87845">
        <property type="protein sequence ID" value="SEG87845"/>
        <property type="gene ID" value="SAMN04489712_12116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="41" mass="4261" checksum="07CD281BB8546B7B" modified="2017-01-18" version="1">MGNHDNTGDRNRPGQPIPPDRDDKDNIGGGGSRGSDGGKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUF9</accession>
    <name>A0A1H6DUF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv2161c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_122101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88890">
        <property type="protein sequence ID" value="SEG88890"/>
        <property type="gene ID" value="SAMN04489712_122101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="31667" checksum="4FE567E7CB73A86D" modified="2017-01-18" version="1">MRAGIISPVVTRVPGAHAEWERSADIEDLGRIARVADELGFDHLTCSEHVAVPAEVAEVRGGTYWDPLSTFGYLAACTGRIRLATHVLVLGYHHPLEIAKRYGTLDRVCGGRLVLGLGVGTLREEFALLGAEFEERGRRADDALAALRAALSRRDPEYHGEFYDFSEMIVEPHAVQPRVPLWIGGRTPRSLRRAVRSGDGWVPFGLSPDELAGMLAAVDLPEGFEVVLTAERMLDPIGSPEGVERRLRALGAAGATVVGVRLSAESVAHYCEQLEALHTVLQEIDGRVAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVN9</accession>
    <name>A0A1H6DVN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88786">
        <property type="protein sequence ID" value="SEG88786"/>
        <property type="gene ID" value="SAMN04489712_12279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="30465" checksum="EDA7D93AB841E978" modified="2017-01-18" version="1">MPDRTLKVGLTQWHATRDVAANVETACAMIHACADADLVLLPENGLMLGTNAEMRDAALTVDSPQIDALREAAGAAGTTVVLGGFKRRTGEVIHNTALVIAADGRVAGGYDKIHLFDARIEGRSFEASGVETGGDRPALLRVAGVTVGLTICYDVRFPELYRALALAGAQVLLVPAAFTQRTGEAHWELLLRARAVENSAYVVASATVRGADDDAFPTYGHALVAGPWGEVLADLGTAPAASRVLELDLDEVTRRREMLPVLRGVRPDSYGGPAQVIDADKVDEGELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVX6</accession>
    <name>A0A1H6DVX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89408">
        <property type="protein sequence ID" value="SEG89408"/>
        <property type="gene ID" value="SAMN04489712_12386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG89408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="20953" checksum="09DF0247A441D75B" modified="2017-01-18" version="1">MDSPDQHVEKIVAERLLYTGRTIKVFELKVETKPGVYENLEIVEKAGDSVAILPVDDSGNVHIIKEYYAAADSRLYSLPKGTIEAGESPQEAARREMQEEVGLAGDLTPLAVFDLSPGYLRQRTSIFLARNLRHVPVGGDEVTFIAPVSIPYDQAIAMALSGEITEARLVAALFLAQPHLKRARALPSKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWT4</accession>
    <name>A0A1H6DWT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89731">
        <property type="protein sequence ID" value="SEG89731"/>
        <property type="gene ID" value="SAMN04489712_12444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="195" mass="21517" checksum="AD6FBB1970E8E5E6" modified="2017-01-18" version="1">MTHVTEDDLDDLEFATLRTGDHTSAARRLSELAASVSGGVSRAKVLLRAGEQWQHAGDHGKAAELYRQAIEDGGETYGDPRAYLADALFELDRPDEARDLIEQIRADAPRDPEVYRTVAEVLYAQGDLAGAYEWATAGADMVLALRERRTGPGDDLVVAEDSLEGLLRLRYRARIDLGRSEDEYDAMLDDLLKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXL1</accession>
    <name>A0A1H6DXL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90018">
        <property type="protein sequence ID" value="SEG90018"/>
        <property type="gene ID" value="SAMN04489712_12515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="17295" checksum="61FB0DD52AF0616C" modified="2017-01-18" version="1">MSTTADAVTFSDLSRNPKSVAERAARLGRLRVTHRDAPDFYLTAADREEQRDESLTTASRIFLALMKHDPSARALLLAMPDVFPWARHLSTEEVRAFTVELVNALSDAAELDLDTNAQEVITNWRATAQIKADHTEYKEALRPTSGNFDPVKVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYZ9</accession>
    <name>A0A1H6DYZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG89996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89996">
        <property type="protein sequence ID" value="SEG89996"/>
        <property type="gene ID" value="SAMN04489712_1258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG89996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1008" mass="109861" checksum="E9D824A07D3624DF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0C9</accession>
    <name>A0A1H6E0C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91058">
        <property type="protein sequence ID" value="SEG91058"/>
        <property type="gene ID" value="SAMN04489712_12825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="43591" checksum="D9E91D1C0B74ABC7" modified="2017-01-18" version="1">MSTEYQRALGRRIAQERKRRGLSQSELARLIDRSVAWVSQVERGVRKIDRMSVLEKVAEALELPLSELAAEAPVVAATTEEIPGSAGLRLVLSGAHSLRAMLHSAPVPPTDEIRPRVDRAWELAHESRYVELADLLRGLVPALETAVRSAEEERRAELFELLASTYQACSAALAKLGEPEAAWIAADRAIVAAERAGDPLMMAAGAFRLGFVFLGARHFDQAEETARTASEALWFLADEGKPDAMSLWGGLTLQRAVAASRLNQADAAYEHLARAREVAERLGDGHNYYNTEFGPANVALHEVAVAVELGDAGHALRVGAAVDTSTLSAERRARLGIDLARAHAQRRQVNEAVSTLLEAETITPEQIRNHRIVRQLVSDLLAMQDPPSPELRELADRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0R5</accession>
    <name>A0A1H6E0R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90515">
        <property type="protein sequence ID" value="SEG90515"/>
        <property type="gene ID" value="SAMN04489712_12661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="27375" checksum="D7FAD41A7BFE665E" modified="2017-01-18" version="1">MTDTASPDLNVRRDGAVAVLEIDRPPANYFDRALIAAIADALGELESDGRTRAAVLCSSGKHFCAGANFATTADGGDRAIESRRLYDEALRLFHVQIPVVAAVQGAAVGGGLGLACAADFRVATPDSVFQANFARLGFHQGFGLSATLPRIVGPQRALDLLSTARRVRGEEAAAIGLADRIVPTGTERAAALTWAAEIAACAPLAVRSIRETLRSGLADAVGQALEREVAEQARLWETEDSREGIAASLERREPRFVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E169</accession>
    <name>A0A1H6E169_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EF-hand domain pair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91119">
        <property type="protein sequence ID" value="SEG91119"/>
        <property type="gene ID" value="SAMN04489712_12841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="83" mass="8953" checksum="CACC2551C752647C" modified="2017-01-18" version="1">MTAESIEDGLINAFRRIDVDGDGKLDLMGFTLILDELGLSWSRAETQTRFEIADSNRDGLISLGELRAMLVPYNLAGPAGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1F8</accession>
    <name>A0A1H6E1F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91013">
        <property type="protein sequence ID" value="SEG91013"/>
        <property type="gene ID" value="SAMN04489712_12814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="109" mass="11567" checksum="0C19C6FFF7BD3837" modified="2017-01-18" version="1">MNMPDRRSSGQQGHAWDAPGETDTRRAQVWALAQTLSAHGYEAEMAESEPLLVVAVASGSPVQVRCAYRDDCGGEPWFCFVGGTPIAPADDNHLQDAVVAVKGALAGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1U5</accession>
    <name>A0A1H6E1U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90895">
        <property type="protein sequence ID" value="SEG90895"/>
        <property type="gene ID" value="SAMN04489712_12770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="355" mass="39153" checksum="A52D886DD76F913B" modified="2017-01-18" version="1">MRVCVCTVVHHPEDARILHRQIRALLDAGHEVTYMAPFRAWNVTPWRNVSPVDLPRSNGRGLLHALRAARRALADHAAYSDLVLVHDPELLLALPRAARRRAVVWDVHEGPAASPLPEPLLRHARERGARRHRLLLAGEEHRGRFGEGHPVVPDLPYVPAAPPGEPDDRRVVYVGRLSVGRGALEMIELAGRLAERGVAVELIGAADPQVRPALREAQRRGMLRWYGFVPNDRALRIAEGAMAGLALLHEDPRRTGVPAKVMEYMAHGVPVVTTPGPAVAELVGESECGLVVPFGDVAAAQDAVLRLHGDRGLRAALGRRGYETARARFDWPAHAERFVDLLEEWADRSREPMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E249</accession>
    <name>A0A1H6E249_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PTS system, mannitol-specific IIC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_12868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91233">
        <property type="protein sequence ID" value="SEG91233"/>
        <property type="gene ID" value="SAMN04489712_12868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004718">
        <property type="entry name" value="PTS_IIC_mtl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00851">
        <property type="entry name" value="mtlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="11">
        <location>
            <begin position="21"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="352"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG91233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="413" mass="43084" checksum="0769D7F08B2E4314" modified="2017-01-18" version="1">MATAYTPQATGTGMRARVQRIGGYLAAMVMPNIGAFIAWGLITALFIPTGWLPNEDLAELVDPMIKVLLPVLIGYTGGRMVHGQRGAVVGAVATIGVVVGADAPMFLGAMIMGPLAAWLMKLFDGLVEDRVRPGFEMLVDNFSAGILAAAMAVAGKWAIGPVVRTVTEAAGDAVGWLVDHDVLPVASVLIEPAKVLFLNNAINHGVLGPLGVQQAAEAGKSIMFMLESNPGPGLGVLLAYTFFGPRRLRPTTPAAMIIHFFGGIHEIYFPYILMKPRMILAAIAGGATGVAIFMAFGTGLVATPSPGSIFAYLAQTPRGVGNWVGVYTGMLASAAVSFLVGSALLGFGRLAEPRTETGEDGGEDGDRTQDRAETDDQHGDETAHPGGRDTGADGVRDDSSRPTVTLTERADPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2Y4</accession>
    <name>A0A1H6E2Y4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91917">
        <property type="protein sequence ID" value="SEG91917"/>
        <property type="gene ID" value="SAMN04489712_13127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="61" mass="6241" checksum="C86BE8F62CC9D3FB" modified="2017-01-18" version="1">MKITVDLGRCQGYANCVAAAPDVFDVDDATGKAVLLAAEGDAAEIREAARSCPVAAIGMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E537</accession>
    <name>A0A1H6E537_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="3">MTA phosphorylase</shortName>
            <shortName evidence="3">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtnP</name>
        <name evidence="5" type="ORF">SAMN04489712_13232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92124">
        <property type="protein sequence ID" value="SEG92124"/>
        <property type="gene ID" value="SAMN04489712_13232"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="29011" checksum="61F253424162564D" modified="2017-01-18" version="1">MTTANAEIGVIGGSGFYSFLDGLDEVRVDTPYGPPSDPIAVGTVAGRRVAFLPRHGRDHRYPPHKIPYRANLWALRSLGVRQVIAPSAVGSLTPAYGPGTLAVPDQLVDRTYGRAQTFYDEGGAIHLSFADPYCPVGRRTALDTAHKAGWEPVDGGTLVVIEGPRFSTRAESQWYAAQGWTLVGMTGHPEAVLARELALCYTPLCLVTDLDAGIEEGEGVTMEEVFRVFAGNVDRLRTLVTTLVESLPADRACPCPHALDDMELPLQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6S1</accession>
    <name>A0A1H6E6S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type branched-chain amino acid transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92961">
        <property type="protein sequence ID" value="SEG92961"/>
        <property type="gene ID" value="SAMN04489712_13629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296603" evidence="1">
        <location>
            <begin position="21"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="44"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="41469" checksum="25DE303E24861900" modified="2017-01-18" version="1">MRRALSLAALTALAAATVTACSGSGSESEYGKDLTGEPINLSVIASGPGPIYQPELLKAAQATANAINDAGGVKPGGGGAARPIKLIHCEASTVTDPNAATKCAREAIDKKVIAGVGKYVSSDAVVQAFHGAKIPLVGTQVQTGQDFTSPASFPIQGGSPMLSAATGVALQQAGAKTVAVVTGDSPSGRLVPQYVKALLADPGDLKGAHYLPFDVSADLTSHFSQIAGARPDGVALLASTDVTTKTIVGLRQAGYRGKIAVVATAVSEASLAKMGDASEGTVVVSDYDAATNTANPKIKQFVDEMDKYGDGKIEGTEFALNVWAAIHLVADRLNGATDISGPALMKSLEGSKVSIGIAPDFTYGSPNFLKLPRLPRATVQFQTVQGGKIMAPEGGTFTDLNQFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E753</accession>
    <name>A0A1H6E753_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93083">
        <property type="protein sequence ID" value="SEG93083"/>
        <property type="gene ID" value="SAMN04489712_1377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018735">
        <property type="entry name" value="DUF2277"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10041">
        <property type="entry name" value="DUF2277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="72" mass="7693" checksum="4CDA0E87B710C2DE" modified="2017-01-18" version="1">MCRSIKTLRPPFQDETTDADIHAAALQYVRKVSGFRAPAAHNAEAFDRAVAQVAAATADLLASLQVRGRPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E879</accession>
    <name>A0A1H6E879_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93065">
        <property type="protein sequence ID" value="SEG93065"/>
        <property type="gene ID" value="SAMN04489712_1372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="57" mass="6032" checksum="6E7BF616C3FF3600" modified="2017-01-18" version="1">MTTSSIPRPKSGDDRRPIRSTSLRALAVAAHLERGLAAEGPPGRDEPSVECTESETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8A1</accession>
    <name>A0A1H6E8A1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93952">
        <property type="protein sequence ID" value="SEG93952"/>
        <property type="gene ID" value="SAMN04489712_1426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="30925" checksum="370D1C1F6DD083F5" modified="2017-01-18" version="1">MTDATPPTARERFAGGTAVVTGGAAGIGEGFVRHLAGIGMNVVIADLDLDGGRRLAGELAAGQGRVVATQVDVADPEALEGLAEQTFAQFGSVELLVNNAGLETAGLLWEIPVARWRQLMSVNVDGIFHAVRAFLPRMIELGRPAVVANMSSVGGVSSAPLQTPYMVSKHAVLALTECLHQEVALTGAPIQVSAILPYSVKSRIFLSAQAAAPTADPTANRLFDAMQAANVADGMDPLEAAAHMTAALAAGDFWVFSDDTAGKAALDARAEVLAGQSPPRDPHAMLAEIEAMALPAGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E996</accession>
    <name>A0A1H6E996_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94287">
        <property type="protein sequence ID" value="SEG94287"/>
        <property type="gene ID" value="SAMN04489712_14514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="30466" checksum="A26F4F006DCA84A1" modified="2017-01-18" version="1">MADVMSGPVTVVGVHGVGNHQAALGPVAAADRIAGWWHNALLAGLQRPHEESGLQVRMAYYADHLRTRTPQGPEELDALDKAAQARVIAWARLLGADEPTVQGWVTAPVRAAISWVANRYGLDHGAVRALVARFFGEVETYFTEPGRRERARIRVAEAITAVHPQVVIAHSLGSVVTYETLWAHELPPIDLLITLGSPLAMPDIVHDRLVPHEGLRRRPPGIGTWINIADPGDIIAIPARGIPARFAGVAADRTNAIGAFDFHRAVRYLKNSATADALTAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5RZ25</accession>
    <name>A0A1H5RZ25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine protease PepD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43470">
        <property type="protein sequence ID" value="SEF43470"/>
        <property type="gene ID" value="SAMN04489712_1019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="285"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF43470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="38321" checksum="1B6A9445D0BEC023" modified="2017-01-18" version="1">MNAGLQAGSKMNAALQAGPEMNAALQAGPKTDAGLHGGLKVAGRAGAAVLLALGLAAGCSAPQSQQRGVGSTGTATVAVDQDAAGLEQQYEKVVRAVLPSVVQIDTGKSEGSGVVYDASGHIVTNAHVVAGADRIRVVPASGGRPMSASLVGSFAADDLAVVKVDGGRLPPAKFGDSARLRVGQIVLAMGNPLGLSGSATDGIVSATGRSVTTAPEGDFPGSTIAQAIQTSAPINPGNSGGALVTLAGEVIGIPTAAANNPQGGAAPGIGFATPSATVKNIVPQLIKEGRVGNSGRAALGVTVRTVLDLRTGRPAGVEVVSVSENGGAAKAGIRPGDIIVAVNGTPTPDQAQLSQVLARLAPGNVARVDITQGSADGARRTVDVTLGQLPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S2U4</accession>
    <name>A0A1H5S2U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44800">
        <property type="protein sequence ID" value="SEF44800"/>
        <property type="gene ID" value="SAMN04489712_10154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015068">
        <property type="entry name" value="DUF1877"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035944">
        <property type="entry name" value="YfbM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08974">
        <property type="entry name" value="DUF1877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111069">
        <property type="entry name" value="SSF111069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF44800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="18511" checksum="D5FFC95B1BB464AD" modified="2017-01-18" version="1">MGLAMSYLRLPPSLEGEQDPGRIAHLVFGRADWRRRHPADRMLDVGGAWQALHYLITGDPWDGRQPGADVVCGGRLLTEDGADGLGMDVIHLVPERVRPAADLLTGTSFDTLAGRFDPAAMAAAEVQDAAGMDETTRDRVLRPAYERLTRLFAAAAADGQAVYKVMVPQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SG52</accession>
    <name>A0A1H5SG52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase accessory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49589">
        <property type="protein sequence ID" value="SEF49589"/>
        <property type="gene ID" value="SAMN04489712_101196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="118"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="208"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF49589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="374" mass="39713" checksum="1B5F26098549AB74" modified="2017-01-18" version="1">MHVRDVLGDIVRWYAAGETFGLATVVETFRSAPRPPGAAMAVSAGGEAAGSVSGGCVEGAVYELAREVIETGRPQRARYGVSDDDAFAVGLTCGGIIDVWVEPVGPRTFPQFGEVAAAIEAHRPVAVATVVAGPGVLGARRVIWPDHAAGSLAPGESYSERLDAAVDDDARGMLAQGLTGSRHYGPRGERRLDDLTVFVQSFAPPPRLLVFGAIDFAAAVARIGKFLGHHVTVCDARPVFATAKRFPDADEVVVKWPHKFLSEIEVDERTAICVLTHDPKFDVPLLEVALRTPAGYIGAMGSRRTHADRLARLREAGLGEAELARLRSPIGLDLGARTPEETAVSIAAELIQLRWGGSGRPLTTTTGRIHGDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJF0</accession>
    <name>A0A1H5SJF0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ORF">SAMN04489712_101239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50773">
        <property type="protein sequence ID" value="SEF50773"/>
        <property type="gene ID" value="SAMN04489712_101239"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="67"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="70"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="128"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF50773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="358" mass="37353" checksum="368760AD283F8CBD" modified="2017-01-18" version="1">MTATRIAVHGDSPYEVVIGPGVLDELPGLLGARVRTVAVVHNAGLPEIAGPVCKALEQAGYTVHALPVPDGEAAKEVGVLAGLWSDFARLGITRSDAVVGVGGGATTDLAGFAAASWLRGVKAVLVPTTLLGMVDAAVGGKTGINIPEGKNLVGAFHPPAGVLCELTTLTTMPREDYVSGLAEVIKAGFIADPKILELVEDDPQGAASPAGRHTRELVERAVRVKAEVVSADLRESGLREILNYGHTLAHAIEKAEEYRFRHGHAVAIGMVYAAELGRLTGRLPAEVVDRHRAVLTSVGLPTGYPAAAWPVLREGMRVDKKARGATLRFVVLDGLADPGRLEGPADDLLAAAYQAIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SS23</accession>
    <name>A0A1H5SS23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ORF">SAMN04489712_101314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52641">
        <property type="protein sequence ID" value="SEF52641"/>
        <property type="gene ID" value="SAMN04489712_101314"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF52641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="26950" checksum="91005D392E8E57A4" modified="2017-01-18" version="1">MAVAVRVIPCLDVDAGRVVKGVNFQNLRDAGDPVELARRYDAEGADELTFLDITASSADRSTTYDVVRRTAEEVFIPLTVGGGIRTVADVDRLLRAGADKVSINTAAIARPEFLREAAHRFGSQCIVLSVDARRVTDGEPTKSGFEVTTHGGRRGTGIDAVEWARRGQELGVGEILLNSMDADGTKDGFDLAMLEQVRAAVTVPVIASGGAGALEHFAPAVAAGADAVLAASVFHFGDLKISAVKDTLRSAGHPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SW87</accession>
    <name>A0A1H5SW87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54121">
        <property type="protein sequence ID" value="SEF54121"/>
        <property type="gene ID" value="SAMN04489712_101367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF54121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="17841" checksum="C61CA873B7BEA7E3" modified="2017-01-18" version="1">MSAEDVEIGPAAERDSGEILTVQRAAYLAEAQLYGDPFISPLVESHEQLRKVLAGDAVVLKATLGHRLVGAVRAQFSGRTCLIGRLVVAPDVQGRGIGGRLMRELEERVAGRVDACVLFTGHLSEGNLRLYRRLGYAETHRERIAAHLTLVHMRKPLRPASAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TKT4</accession>
    <name>A0A1H5TKT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62798">
        <property type="protein sequence ID" value="SEF62798"/>
        <property type="gene ID" value="SAMN04489712_101639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009334">
        <property type="entry name" value="DUF993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06187">
        <property type="entry name" value="DUF993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF62798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="385" mass="40582" checksum="2C0B723A499E8A73" modified="2017-01-18" version="1">MKIWLPGEGGALYAHTPGEPRAHPRPSSPLTSRIAYAAAHVVADPFADNTPGSPAAVDWEATLAFRRHLWAYGLGVAEAMDTAQRGMGLDWPAARELIGRSGAEARACGGRIVCGAGTDQLGPGPAPLDRVIAAYEEQLAVVEDAGAIPVIMASRQLAAAARGPDDYAEVYGRLLGGLRRPAVLHWLGPMFDPALAGYWGSPDPDAAADLLLSIIEAHPGRVDGVKVSLLDAGREVALRRRLPAGVRMYTGDDFHYPELIAGDGSGHSDALLGIFDVIAPAASAALQALDADAPAAFREILAPTVPLARAVFAAPTRHYKTGAVFLAWLAGHQRHFRMVGGMESARSVPHLAGLYRLADAAGLLPDPELAVTRLRSWLAVQGVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TNH6</accession>
    <name>A0A1H5TNH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maleylpyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64365">
        <property type="protein sequence ID" value="SEF64365"/>
        <property type="gene ID" value="SAMN04489712_101690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF64365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="236" mass="24791" checksum="EF0C4BEE5FD53EAE" modified="2017-01-18" version="1">MRRTFEDALSWSAAGTELFLDAVAGWGEEQYLAPSGLPDWTRKHLVAHVAANADALGNLVRWAATGEETPMYSSREQRNADIEAGSQKPAAELAAWLHESADRLAVGTAALSSAQWNAEVVTAQGRTVPATEIPWLRSREVCVHTVDLATGVSFADLPAGFLAALADDITGKRGNAPGPALVLTAADTGDRWELLGEDDATAVAGPLAEVTAYLAGRPHTLTATDGSPAPTLPAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UZ42</accession>
    <name>A0A1H5UZ42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79477">
        <property type="protein sequence ID" value="SEF79477"/>
        <property type="gene ID" value="SAMN04489712_10266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF79477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="27182" checksum="8B08BFF87163DD9A" modified="2017-01-18" version="1">MNIVVCVKQVPDTESPRKLKSDDNTLDRAAADGVINELDEYAIEEALLLKEAHGGEVTVLTMGPDKATDSIRKALAMGADKAVHLVDDALAGSDALGTSYAIQQVLGRTGFDLVILGAESTDARTGMLAAMLAERLGVPQLSLANKVEIDGSSITVQRITDYGYDKVEASLPAVVSVVEKINEPRYPSFKGIMAAKKKPVEKLGVADAGIDADKVGLAGAATEVVDFADAPPREKGQIVTDEGDGGAKIAEFLASKKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V4Y1</accession>
    <name>A0A1H5V4Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sirohydrochlorin ferrochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82260">
        <property type="protein sequence ID" value="SEF82260"/>
        <property type="gene ID" value="SAMN04489712_102163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF82260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="32023" checksum="908146EFC5FE6B87" modified="2017-01-18" version="1">MPAVTPDSEVPLDNMGPEVLPARRRRPRPGGRHRGAESFALPPDSPPLILAVPGALDASVPPVPPGRPGAPEPSGRPVVAGVAGALALLTEHAHTGRPVVLGHLAGSAASLGAALAAAAAAGRAPDMPPAVVVPLLAGPDPVIDRALRETVVASGVPAVIAEPLGPHPLIAQALHERLAEAGLARADRIRMMTTVTVAGGVVIAVPGGPAAVRDAEVSAVLLASRLAVPATAASLEDGPDAISPAEAAARLRAAGATHVAFAPYVIGPEVAPARLAMLSKLAADTGAGLAAPLGDHPVLAHLIALRYVEALEKALREGQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VAR1</accession>
    <name>A0A1H5VAR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized membrane protein YphA, DoxX/SURF4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83517">
        <property type="protein sequence ID" value="SEF83517"/>
        <property type="gene ID" value="SAMN04489712_102210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF83517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="22507" checksum="304B934DD513BBA7" modified="2017-01-18" version="1">MQPIRIVARPLVATHFIVSGLETLRDPRPRAEQMAPSLKSIADRLDWLPSKDPETLVRIQGAIGVGAGTLLALGKFKRLSTLLLAASLVPAVLTEHQYWTEDDPERRETQRSLLLLKGGLLGALLMVATEPRRGQRLAALRRQAHDARTVAAVQSKALRKQAKSELRHTRREAAHQVGQARREAARQVRQARREAVRKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VGE0</accession>
    <name>A0A1H5VGE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85577">
        <property type="protein sequence ID" value="SEF85577"/>
        <property type="gene ID" value="SAMN04489712_102285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF85577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="260" mass="27158" checksum="BC88AD015F0BB125" modified="2017-01-18" version="1">MSPDHRVAVVTGATSGIGLAVTRTLAGLGQRVFVCARTAEDVAGTVKTLRAEGLEVDGTPCDVREPARIEEFVRAAVDRYGTIDVLVNNAGRSGGGVTADLSDELWFDVVATNLHSVFLMTRAVLNAGGMRHKDRGRIVNIASTAGKQGVVLGAPYSASKHGVVGFTKALGNELAPTGITVNAVCPGYVETPMAQRVRQGYAEVWSTTEEAVLERFQAKIPLGRYATPEEVAGMVGYLVSDAAAPVTAQAINVCGGLGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VWS3</accession>
    <name>A0A1H5VWS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91321">
        <property type="protein sequence ID" value="SEF91321"/>
        <property type="gene ID" value="SAMN04489712_102481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF91321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="21247" checksum="F84A05A4D623A473" modified="2017-01-18" version="1">MASATTDSTRERIIDAAEECFARYGVAKTTVEDIAAAAGMSRATVYRSVTGGRDELILAVMLRELTRFLDRLAARLSREDSVPDAVVEGVLDAVSYVRDRPHMAHFMVPEAAGHTQAVVTGAAERILDLCCDHVRPHFEAAQRAGRIRAGIEVEGTTEFLFRIIASLIVMDRGRDTDATRNFLRSYVVPVIVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W145</accession>
    <name>A0A1H5W145_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92517">
        <property type="protein sequence ID" value="SEF92517"/>
        <property type="gene ID" value="SAMN04489712_102527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF92517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="242" mass="26095" checksum="3B23D4755BE40711" modified="2017-01-18" version="1">MAAGGAFVPKYVQIVETLRRRIKDGTYPIGSRLPSEADLVREFGVSRPTVVRSLQEMALLGEIEREHGRGSFVRAVAENREERRPALAVLDRQETDDSVKVVQVGPEAAPARVAARLGVVEGARVHLRRSVGFFDAQIPSEVVSLWAPLDVARSAGLEQAGPLTVPLRRLLTAGTGERLARVVETLTARHPVGPETELLGIAADEPVLGVLASVVDATDRVVLVVEVVLPGSLHDLEDTYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X807</accession>
    <name>A0A1H5X807_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyldihydroxyacetonephosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07869">
        <property type="protein sequence ID" value="SEG07869"/>
        <property type="gene ID" value="SAMN04489712_103131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="93"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG07869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="532" mass="55386" checksum="DD522C6A490E565A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XC59</accession>
    <name>A0A1H5XC59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09338">
        <property type="protein sequence ID" value="SEG09338"/>
        <property type="gene ID" value="SAMN04489712_103189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG09338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="172" mass="19511" checksum="739CBA83A009F399" modified="2017-01-18" version="1">MNDDADFTRFVQDRGPELLRLAVALTGDRDQAEDVVQGALERLYGRWGRVRRRGDPEWYVRRSIVNAVRDGWRGRRRHPEVLGLAAEEHSDQVAYAPIDEVLTRDAVRGALACLPPRQRMVITLRYWGGCTEAETARLMGISVGTVKSQAHRALKELRGRLHTTEIAQGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XH19</accession>
    <name>A0A1H5XH19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10657">
        <property type="protein sequence ID" value="SEG10657"/>
        <property type="gene ID" value="SAMN04489712_103236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="30"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG10657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="555" mass="61642" checksum="ACBBF2C718FDC930" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZU7</accession>
    <name>A0A1H5XZU7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lexA</name>
        <name evidence="16" type="ORF">SAMN04489712_103476</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16890">
        <property type="protein sequence ID" value="SEG16890"/>
        <property type="gene ID" value="SAMN04489712_103476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="115"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SEG16890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="233" mass="24954" checksum="88CF88092397C225" modified="2017-01-18" version="1">MSKVRELPDGPMDDSGLTQRQRMVLEVIRDSVQRRGYPPSMREIGEAVGLTSTSSVSHQLRTLQRKGYLRRDPNRPRAVEVRVPGAAAVRVEGAAAPAFEAAGGQESGPTPAMVPLVGRIAAGGPILAEETVEDVFALPRQLVGEGTHFLLKVSGDSMIEAAIADGDWVVVRQQPVAENGDIVAAMIDGEATVKTFKLKDGHVWLMPQNSAYDPIPGDEASVLGRVVAVLRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YHC8</accession>
    <name>A0A1H5YHC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23493">
        <property type="protein sequence ID" value="SEG23493"/>
        <property type="gene ID" value="SAMN04489712_10415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG23493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="29907" checksum="FBEBCD6B692F2DE2" modified="2017-01-18" version="1">MRGDRVEELPAEIRDLIEKRTGLIARFQSASGGSNANIAATLHTADGQIFVKAARKPVDGEGPGIRSLRREAVINPYIREFTPRLLWHLETKGWVALGFECVAGRHADYSPGSPDLAVLAKVIHRLQDTSCPDVVEMRVERRWASLACDVSAMAGDALLHTDLNPKNLLITLAGRVHAVDWAFASRGASWVEVGQTVRWLIRAGHSPAEAEEWASQFPSWTTADPVAIDLYAQLSAERWRRHAESKGVAKVPEYVAVAQRWADHRKSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YK14</accession>
    <name>A0A1H5YK14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24032">
        <property type="protein sequence ID" value="SEG24032"/>
        <property type="gene ID" value="SAMN04489712_10440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG24032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="15192" checksum="2E219B02DDE1ED41" modified="2017-01-18" version="1">MTQIARNTRRPWLRFAWHYLEMVIAMFVGMAVLGLPLAAAGVSFSHERNPEPAYLLMAFTMSVGMAAIMRYRGHGWPATLEMCATMFAPALPLFPLLWLDVIDAEALMLLAHVAMFPLMLAVMLRRRTEYTGCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YVN4</accession>
    <name>A0A1H5YVN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27822">
        <property type="protein sequence ID" value="SEG27822"/>
        <property type="gene ID" value="SAMN04489712_104196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="27965" checksum="5E7A33ED52DC30CD" modified="2017-01-18" version="1">MGVVNVTPDSFSDGGAWFDPDKAIGHGHDLVHEGADLIDVGGESTRPGAQRVSLAEELRRVVPVIEALAADGIPVSVDTMRAEVAEAAIGAGARLVNDVSGGLADPDMARMLAGAGIPYVVMHWRGHSRDMDHRAEYADVVAEVRAELHERVDAVVAQGVDPSMIVLDPGLGFAKKAHHNWTLLARLGELSGDLPVLVGASRKRFLGRLLTEPDGHPRPFTDCDDATVAVTALSAAAGAWCVRVHRVRPNADAVRVAAAVRAAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z6B1</accession>
    <name>A0A1H5Z6B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-hairpin-helix motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30916">
        <property type="protein sequence ID" value="SEG30916"/>
        <property type="gene ID" value="SAMN04489712_104330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG30916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="23187" checksum="BD82C02D9EB91927" modified="2017-01-18" version="1">MPPEPPRSQGVLWAFTPLITCGFATPFTFTYAAVKRRSAGLAVASAGYLAGWSAMITFMDAGWPLSALASMLLMILWIGGFAHALTVRTRVYPQAAPRDKANEYAIHVAKYRRTLREEARTLAAEDPALAHELGIGRPDVPRAYDDGGLIDVNHAPPFVLATLPGMTSELVERIERIRREQGPFVSVEELAINADLPPDLVTRVGEYAIFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z7E2</accession>
    <name>A0A1H5Z7E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32064">
        <property type="protein sequence ID" value="SEG32064"/>
        <property type="gene ID" value="SAMN04489712_104391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291291" evidence="2">
        <location>
            <begin position="20"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="114"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG32064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="433" mass="46308" checksum="CFA0504E2942E6DD" modified="2017-01-18" version="1">MRRSGTILRLGGVLVVVAALVAAAVVLLQEPPQRRLTAYFERAVGLYPGADVRILGIPVGKVTKVTPKGDAVLVEMTYEARRKVPADAQAVIVSQTLVSDRFIQLTPVYKGGPTLPDGVTLGTDRTAVPVEVDEVGGSLNDLSKALGPEGANSDGSLSRLLQVGADTFEGQGEDLRQTIADTSRMLSTLSEDREDVATTIENLRVITAAMVRSDQQIRQFNQHLAGVSGQLAAEREELSAALNTLGPTLRNVQRFIKDNRGELSTNVRQLAQITGVLVKQRKSLTEFFETAPLAINNLARAYDPISGTINTRANLSQNLGNLADWICSLAYSVGTPAKQCLDFMKPYDSFGDALTHLSLDLSWVTALTTHYDPEPIPPDAYGPNDPRNPRKGGKGVVNAAGNNRNTGAGTTDPNGDTQRRGGDFRSLLPGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZAU8</accession>
    <name>A0A1H5ZAU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33431">
        <property type="protein sequence ID" value="SEG33431"/>
        <property type="gene ID" value="SAMN04489712_104455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="162" mass="17416" checksum="5AC30CB282F706B3" modified="2017-01-18" version="1">MRRTAAALTAVSCALLTGCGIRPTGIISAGDKPFIGSRDTSVTVYLVSARERLVPVVRPGLPGHPHHAVTQLGVRPTSLERHRGLRNAVPARDLLVRVADDPSMLMVDVDGKLPWPRIARAQVVCTAQTIAGIRRVMLVGLPDSEGDNWVSHACDEFADLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZCR2</accession>
    <name>A0A1H5ZCR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_104483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34092">
        <property type="protein sequence ID" value="SEG34092"/>
        <property type="gene ID" value="SAMN04489712_104483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="53"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG34092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="228" mass="24951" checksum="960F272CC835C89D" modified="2017-01-18" version="1">MATRSRRDAFRSGVHRQGRRDVLLTVLLVALLGGLFALYGPLNEGPARWSLKTPLDAHIPLVEEMVIPYVSALALGPLTLLLFLLTSTRTAQSALIASIVLMVVAYLFYVFAQTHVARPEVTGDDLFSRLLRMVYGNDNAYNCFPSLHTGFSVIIAVHWLRHDRRIGGYVAAWCALIIASTLFVHQHYIADMLAGLATASFACWAAARLTARLPALRTAQEADSASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A0T0</accession>
    <name>A0A1H6A0T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mg/Co/Ni transporter MgtE (Contains CBS domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41962">
        <property type="protein sequence ID" value="SEG41962"/>
        <property type="gene ID" value="SAMN04489712_105109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="284"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="353"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG41962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="438" mass="47767" checksum="18445EAECA2901F4" modified="2017-01-18" version="1">MSAPTRVFIARLAGIAVFDPAGDQVGRVRDVVVALRIGPRPPRVLGLVVEVQPRRPVFLPITRVTTIEADQVVFNGRLNMRRFQQRESETLAIAELLDRTVRLADTGEQVAVVDVAMEPTRSRDWLLTKAAVRRGGGRGLRRRRGEILVVDWDAITGLSGVEYGQGAAGLIAAFEQLKAPDLANIIHELPEKRRAEVAAALDDERLADILEELPEDEQIEILGKLDSDRAADVLDAMDPDDAADLLGELPADQRERLLTLMEPEEAAPVRRLLTYADNTAGGLMTTDPVIVPPDATVAEALAHIRNPDLDPALAAQVYVCRPPTDTPTGRYLGTVHFQRLLREPPSELVSGLVDTELAPLRPALSLEAVATFLATYNLVAAAVVDDAGHLLGAVSIDDVLDHLLPEDWRETVLEAIADESTDPEEEALRRSAHARQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A4S4</accession>
    <name>A0A1H6A4S4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43738">
        <property type="protein sequence ID" value="SEG43738"/>
        <property type="gene ID" value="SAMN04489712_105214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG43738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="383" mass="41088" checksum="A852550653222294" modified="2017-01-18" version="1">MSSGVEADIALDAAVVLSLGMTRVAGRAAGLTAAGAQALAALAQGRADARAAALAEAERQDRAVREVIDRNARIAVLAEAQRETGTRVPLPAPLPPGDGSPEELAAWCAATDRALAEAERRIREQAAAGVAAKVFGVPADGLRADLDAPAPAPGDVGRADQAGHRAETLVRVLARLAPDTAAADREFVAEAAGRLPGAATDAEAEALLTEVRLRVQTANERTAERREAERRQAAERDAAEQAEAERRYVLDAVTTAFEELGYEVDAGFETLTARDGTVVLSRGGWPDHSVKMRVEDARTIRAAMVRTRAPRSEDDRRRDAEREREWCAAFEAARERLAAAGIDSTVTWRIEPGDHELPVAAQARQTRARTRQRARERGRERES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A8W3</accession>
    <name>A0A1H6A8W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44186">
        <property type="protein sequence ID" value="SEG44186"/>
        <property type="gene ID" value="SAMN04489712_105238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="15500" checksum="59B1FCE0955A66DD" modified="2017-01-18" version="1">MTTDATITGSHHHESTSPYPLARLYVVRRACYAASLVVAGGGMIAVAAVAGTSHWPVYNTALAVIILGGMAGALAVAAYIAQLVMEHISITSSRALMEVDGSDRHLEQRLERRLERVERHEESIAAALAERYEDDLSRRRTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A8W9</accession>
    <name>A0A1H6A8W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44901">
        <property type="protein sequence ID" value="SEG44901"/>
        <property type="gene ID" value="SAMN04489712_105277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="71" mass="7622" checksum="E6473AA1F3024185" modified="2017-01-18" version="1">MRKKFVGPVNPGPDGKDMGHDVVIGGRSLGNVKRNDVIEVPADIAQMDPAPVWPEGLWEDAPAKKKSEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9B3</accession>
    <name>A0A1H6A9B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage portal protein, HK97 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44794">
        <property type="protein sequence ID" value="SEG44794"/>
        <property type="gene ID" value="SAMN04489712_105271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006944">
        <property type="entry name" value="Phage/GTA_portal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006427">
        <property type="entry name" value="Portal_HK97"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04860">
        <property type="entry name" value="Phage_portal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01537">
        <property type="entry name" value="portal_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="398" mass="43807" checksum="56DFF6E56576B08A" modified="2017-01-18" version="1">MSLFSRRHAALTVLADQLIPARPQRSGTPTVTQETALRHSAVWACLRLRADLVSTMPVDVFRRVARRQVEVPRPPVLVAPGATVITTNGDRVDLGEWLYATQMDLDRGGNVFGLITERDGMGLPARIDLVPLADVTVVIRDGVLTYRIAGTKYEPHQVWHERQFTVAGLPVGLSPVAYAAWSIGEYLSVQDFALDWFGSGAIPSAHLKNTVKQTLTAGEASVAKERFKAAVEGRDLFVTGSDWEYSMIQAEAAGADWLEAKRFGIGDIARFFGCPGDLIDAAVSTGSITYANITQRNLQFLIMNLGPTIIRRENALSRRLLPQPRFVKFNTDALLRMDPQTRAQTIKTQLDARILAPSEARELDNRPPFTDQQLAEFDRLYGVPRTQPSTAAATGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9L5</accession>
    <name>A0A1H6A9L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44426">
        <property type="protein sequence ID" value="SEG44426"/>
        <property type="gene ID" value="SAMN04489712_105251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="15357" checksum="8E79BB69213AC287" modified="2017-01-18" version="1">MAELDEQDRAMLDELGRDWNRVNWEPNPVRDPADEALSPTPEEMAEAPGAEQRTYRITYERVGRRGGRNGSEPPPPLTARVMSTDHLAVRIWEDVKPFLLSSDVEVSVDLESGRGQIFCGFNNGGSFAIERLDGQADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AFE2</accession>
    <name>A0A1H6AFE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47479">
        <property type="protein sequence ID" value="SEG47479"/>
        <property type="gene ID" value="SAMN04489712_105423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG47479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="431" mass="46887" checksum="5B54EEFF30314FE3" modified="2017-01-18" version="1">MELSVVMPCLNEAETIETCVRKTIGFFEDNGIDGEVVIADNGSTDGSQQLARAAGARVVPVADKGYGNALMGGIRAARGRYVAMGDADDSYDFTTLLPFLHELRDGADLVMGNRFKGGIEPGAMPPLHRYLGNPVLSFVGRLFFGSKIGDFHCGLRAFRKDSIMRLGLQTGGMEFASEMVVKATLARYDIREVPTTLSKDGRSRPPHLNTWRDGWRHLRFLLLYSPRWLFLIPGLLFMLVGLVAGVALSFGPVRVGEIAFDVDTLVGAGAAMVIGFQAVLFALFTKVYAMEEGFLPRDRRVDRLVAWWTMERGLVLGGLLALAGLVGLAASLLHWRINNFGELDPRQSLRMVVPAATALVMSFQAIFASMFVSILYIRRREHPALPDPADEAAVVVDAAADRVAAEEAREAKEAKEARVAVAAEGEAGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AHZ5</accession>
    <name>A0A1H6AHZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix of DDE superfamily endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47697">
        <property type="protein sequence ID" value="SEG47697"/>
        <property type="gene ID" value="SAMN04489712_105435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_4" evidence="1">
        <location>
            <begin position="54"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG47697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="18944" checksum="2A5133745BB0B74D" modified="2017-01-18" version="1">MERGDLGSCSINSVDARSVEWFTGLSLPEFMTLAATVRARTGDGADRGRTGRPWALSLVDRILLVACYYRSNASVRQLAVLFGVTHSAVGRTIKRLGPHLALQPVPHLRLRTSELLVTGRAGEVEAAPGHGRRKEQLRMVINVGTRLVLAADGPRVRDAGAREKCSPNETSGDCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AIC1</accession>
    <name>A0A1H6AIC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_105440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47775">
        <property type="protein sequence ID" value="SEG47775"/>
        <property type="gene ID" value="SAMN04489712_105440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="15"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG47775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="24767" checksum="DD61A147A163AB8C" modified="2017-01-18" version="1">MNTASAEPPATAAIRVLLADDEGLVRSGFKVLLDLEDDITVVAEAADGAEAVERARAARPDVVLMDIRMPKLDGIQATAEITRMRGLEGVRILILTTYDTDAHVFEALQAGASGFLLKDAGPAELLHAIRVVAAGEALLAPRITRRLIGQFTARRTAAKSAQDRLAVLTEREREVLALVGQGLSNQEIGAELFLSPATARTHVSRAMAKLGARDRAQLVVIAYRTGLVSPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYZ7</accession>
    <name>A0A1H6AYZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53257">
        <property type="protein sequence ID" value="SEG53257"/>
        <property type="gene ID" value="SAMN04489712_10682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
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        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
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        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG53257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="35364" checksum="1671792A8A8C3D7E" modified="2017-01-18" version="1">MSAPASAQELEPRSSGERPPAARTALRAAGLVGSLLVLLAVLTLSIGVGARQLSPGEVWQGLVDSQSAAHAVVHQMRLPRTLLGLLAGAALGLAGGVMQALTRNPLADPGLLGINAGAAAAVASAGAFLGVATFDGYVWFALAGTATVAALVYAVGGGRGATPARLALAGAALNAALYSYVSAVMLLEAASLERMRFWTVGSLASAQSTTVVKVLPFIAVGLVLALALARPLNALALGDDSARALGARPALVRTAAIAAVTLLCGAATAACGPIVFVGLMVPHLVRALTGPDLRWMFPYCAVLAPVLLLGADVLGRVLARPGELQVGIVTAVLGGPFFLYFVNRAKMVGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2N7</accession>
    <name>A0A1H6B2N7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_106205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55118">
        <property type="protein sequence ID" value="SEG55118"/>
        <property type="gene ID" value="SAMN04489712_106205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="17"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG55118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="423" mass="42452" checksum="E768FF9FBF85EE0C" modified="2017-01-18" version="1">MPQTPAAPSKPGVSGALLAVLALLSAVAPFATDMYLPAFTDMADDLDAGAAGVQLTLTAFLVGLATGQFISGPLSDRFGRRAPLLLATSVATLAAALCALAPNVGTLVAMRFVQGFTGAAGIVIARAVVADRTTGQAAAKVFSLLASIGGIAPVVAPLAGGALVPAGWRSVFWALTGISALMLLGALFVVPESLPRARRHSGGLAATGRAMRRLLTDRGYLGHILTFAFAFAGLMGYISASPFVVQNVLGLSTTAYTLDFAANALGMVVTGLVNARLIGRFTPQALLRFGQGAVLLGSAALAAMLAAGLPAAAVLPVLFLVVSSFGLVMGNSSALAMGRAPYALGTGAAMMGALQFSLGALVSPLVGLGGEETGIPMGITMLTAALLGVAAHLLSRHAPPLPPQTATPQTETTAPQTETTPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B434</accession>
    <name>A0A1H6B434_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA thioester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55611">
        <property type="protein sequence ID" value="SEG55611"/>
        <property type="gene ID" value="SAMN04489712_106244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG55611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="16787" checksum="065E021168109F10" modified="2017-01-18" version="1">MDTDTPPAEYRHVYEFNIRFGDIDSQGHVNNVKFLGYLEDARLEMFHGDPVRKGEEPVRGMVIARHEIDYRRPLLPTVYPIRVETWVTEARAASFKLAYEVRDDEQVFATATSTLVAFDVERNSLRRFTPYERDFIKRYVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B4N0</accession>
    <name>A0A1H6B4N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-4 C11-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_106259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55788">
        <property type="protein sequence ID" value="SEG55788"/>
        <property type="gene ID" value="SAMN04489712_106259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG55788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="28950" checksum="F6F18F512A25CFB4" modified="2017-01-18" version="1">MTSGKVVFVGAGPGAADLLTFRAARAIGEADVVIWAASLVHPDVLEHARPDAEIVDSARLPMEGVLPYYERALAEGLTVARIHSGDPALWGALQEQIDRCREMGLSTEVIPGVSSFSAVAAAVQRELTIPEVAQSVVLTRLGGGKTPMPPGEEVREFARHGTTMALFLSAARSRQLQDELTEGGYPPDTPCVVAYQCTWPDELIVRCTLGELADTVKAHKLWKHTLVLVGPALSADGTRSHLYHPGHFHGFRRADRTARAELRKAHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5C5</accession>
    <name>A0A1H6B5C5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrogenobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hydrogenobyrinic acid a,c-diamide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="6" type="ORF">SAMN04489712_106262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:12544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:77873"/>
            <dbReference type="ChEBI" id="CHEBI:77874"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.9" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55822">
        <property type="protein sequence ID" value="SEG55822"/>
        <property type="gene ID" value="SAMN04489712_106262"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043802">
        <property type="term" value="F:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="6"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="269"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG55822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="470" mass="49626" checksum="8A68F98203F3457B" modified="2017-01-18" version="1">MVTPRLVVAAPASGAGKTTVATGLMAAFAARGLRVSPHKVGPDYIDPGYHTLATGRPGRNLDPFLTSEELIVPLLRHGARGADVAVVEGVMGLYDGASGQDDFASTAHIARLLDAPVVLVVDASAAGRSVAAVVHGFRTYGDVRIGGVILNRIGSDGHEHLCRTAVEELSVPVLGVLRRRDDVATPSRHLGLIPAAERNAEAVATVERLGEIVTEGCDLDALLALARSAPPLTAPAWSPDDALGEHDAARAARDGEAGRAGRAGRRRVVAVAGGAAFTFGYAENEELLAAAGAEVVRFDPLRDETLPEGTRGLVIGGGFPEMYAAELSANEPLREQIRQLVTPRTPVYAECAGLLYLVRELDGVPMCGVLDATATMTPRLTLGYRTAVATADSVVARTGERLNGHEFHRTAVQPAHGPDETAAWQWAMRPSGSRRDGFARGNQLASYLHLHWAGEPRTARRFVDAMEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BDR7</accession>
    <name>A0A1H6BDR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein, DUF849 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58812">
        <property type="protein sequence ID" value="SEG58812"/>
        <property type="gene ID" value="SAMN04489712_10723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG58812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="26204" checksum="4DCEB419AE61A5A6" modified="2017-01-18" version="1">MRLISSPAVCNNAGMLQVCPNGARTKADDDGIPVTSGELAVAVRNAVAAGARDAHLHPRDDAGAETLEPGPVTRAVTAVRAAAPGIPVGVTTAAWAEPDPHRRAALVRSWPVPPDHASVNWHEEGAELVAQALLERGVGIEAGIFSGTDAAERFLAWPQADRVLRVLAEVVDTDPESATATARDLLHRLRPATRPVLLHGEEGGAWPVLRLARELGLDTRIGLEDTLLLPDGSPAPGNADLVRAALEIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BE46</accession>
    <name>A0A1H6BE46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59079">
        <property type="protein sequence ID" value="SEG59079"/>
        <property type="gene ID" value="SAMN04489712_10745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG59079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="27720" checksum="7CA3F7B2B11BFB6A" modified="2017-01-18" version="1">MASGTLAVGGLSVSYGKAVQALREVSLEVPEGTVTAVLGANGAGKSTLLRAVSGTLPFHRGSIEAGEITLGGRRLSGLRPDAVVAAGVVQVPEGRRVFGRLTVEENLRAGALGARDRSGAAAARERVMELFPVLAERARQRAGLLSGGEQQMLAMGRALMARPKVLLLDEPTLGLAPLMAERIGETVAEINRQGTAVLLIEQNAALALRLASTAHVLEVGRVTLSGPADALAASDEVRRRYLGVGDDDALEPRFQRPPTLERWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJ47</accession>
    <name>A0A1H6BJ47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60779">
        <property type="protein sequence ID" value="SEG60779"/>
        <property type="gene ID" value="SAMN04489712_107156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="294" mass="32180" checksum="49C76566A10FCD89" modified="2017-01-18" version="1">MWSEDARAHGRVPVRVVLRGEPDGWHCVVADQAGSEQRIPLGESGVRWQTGGRRDEEPPWWRRRLAEIAESLRERVATMLTDRCFELFGCEADIAWFGVDEPILWEGLVTLREPDPARFPGGASPFVVTLAPGRGVLLPGADVLFETLAADAWTALEAVSRSCRTPLPRRSFLCGSADHRSVRVGRGSLAVSTDRRPDGTERVGMVFGERPLGWGGNPGLRLRLDGIDLLDEPAEDVVRLLGELGHEVVGHGRLRRLPALGLTLYGREGRSPDDDGRFAGASLAPPDARGLHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJF1</accession>
    <name>A0A1H6BJF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urea-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60525">
        <property type="protein sequence ID" value="SEG60525"/>
        <property type="gene ID" value="SAMN04489712_107137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06355">
        <property type="entry name" value="PBP1_FmdD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017777">
        <property type="entry name" value="ABC_urea-bd_UrtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03407">
        <property type="entry name" value="urea_ABC_UrtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293781" evidence="1">
        <location>
            <begin position="32"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="405" mass="43396" checksum="52B3D58246A1E5E4" modified="2017-01-18" version="1">MRKRSLRYWASLAVLPAVLLTGCGDSGDSGAAAGDGNTIKVGILHSLSGTMAISEVTVANAEKMAVEEVNAAGGVLGKKVEIVQEDGASDWPTFAQKAQKLIKKDKVAAVFGGWTSASRKAMLPVFERNRALLWYPVQYEGLESSPYIFYTGATTNQQIVPGLDYLKEKGAKRIFLVGSDYVFPRTANKIIKAYAAANGMQILGEEYTPLGHTEYSTLVNKVVAAKPDAVFNTLNGDSNVSFFKQLKSAGVTADEMPVMSVSIAEEEVKGIGVANIVGHPVAWNYYQTTESAANDEFVRAFQARHRGAVTSDPMEAGYNAVHLWAAAVKKAGTTDVEAVKKAAAGISLDLPEGKVTVDGGNQHVYKTARIGVIQPDGLIKEVWSSDEPIKPDPYLKTYPWASGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNB4</accession>
    <name>A0A1H6BNB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease V</fullName>
            <ecNumber evidence="1">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyribonuclease V</fullName>
            <shortName evidence="1">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfi</name>
        <name evidence="2" type="ORF">SAMN04489712_107280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endonuclease V family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62198">
        <property type="protein sequence ID" value="SEG62198"/>
        <property type="gene ID" value="SAMN04489712_107280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG62198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="24125" checksum="F22E6BDA17197A70" modified="2017-01-18" version="1">MEVRALHPWPATPGEAETIQDRLRPLLDLTGPGPAAPRTAAGLDVSYEEGTDRLAAAVVVLDMATLQPVEESVVIGTAAFPYVPGLFAFRELPTLIEALERLSVTPDLLVCDGHGLAHPRRFGLACHLGVLTGLPSMGVAKTHLLGSYDPPDRARGSAADLRHDGQVVGRVLRTQDDVRPVYVSVGHRIGLDTACRHALALSPHYRLPETTRHADRLGRRALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNK3</accession>
    <name>A0A1H6BNK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_107263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61987">
        <property type="protein sequence ID" value="SEG61987"/>
        <property type="gene ID" value="SAMN04489712_107263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG61987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="29190" checksum="8BA4E7F1E9429592" modified="2017-01-18" version="1">MSDFLQYLISGLAVGCGFALLASGLVTIHRVTRVVNFAQGMFAVVAGLTAGSLLSAGLPHGLAEVAAVAVAGAAGLLVGLIATGRRGTSAQSALIVTLGLGFVAYAVEIMIWGDNPRSHPGLGGSVQFAGAFVQKQSFLVIGVTAVVFAALWLFFNRSYPGKALSACASNPYAARAVGIDVTRMGLVAFALGGMLGGTAGVLLTPMLPISYNSDVLLITNGFAAAVLGGLNRPGPALAGALVLGVAEAMVAGYYEAAYQTVVALALMLAIMIWQSSRRTALQEETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BQJ9</accession>
    <name>A0A1H6BQJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">SAMN04489712_107299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62476">
        <property type="protein sequence ID" value="SEG62476"/>
        <property type="gene ID" value="SAMN04489712_107299"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG62476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="389" mass="40751" checksum="595FA64F861AC817" modified="2017-01-18" version="1">MSVQLGMPAVRTQSPAVATRRKSRQVMVGSVPVGGDAPVSVQSMTTTLTADVNATLQQIAELTAAGCQIVRVAVPSQDDADALPAIAAKSQIPVIADIHFQPKYVFAAIDAGCAAVRVNPGNIKKFDDRVGEIARAAKDAGVPIRIGVNAGSLDKRLLAKYGRPTPEALVESALWECSLFEEHDFRDIKISVKHNDPVVMIEAYRQLAARCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSEGIGDTIRVSLSAPPVEEVKVGTAILEALGLRERGLEIVSCPSCGRAQVDVYTLAEEVTAGLKGFPVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPESQIVETLIEEAMRIAEEMGVEVDPEAGDGAAQVVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BW39</accession>
    <name>A0A1H6BW39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbpA</name>
        <name evidence="4" type="ORF">SAMN04489712_10860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64862">
        <property type="protein sequence ID" value="SEG64862"/>
        <property type="gene ID" value="SAMN04489712_10860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG64862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="124" mass="13311" checksum="6FB272E4D66BD67E" modified="2017-01-18" version="1">MGSGNAIRGSRVGAGPMGEAERGDAAPRVWVSFYCANRHETRPSFATDVAIPDTWDCPRCGFPAGKDAENPPAPPKTEPYKTHLAYVKERRSDADGEAILEEALAKLREKRAAVRAAMEAAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C0H0</accession>
    <name>A0A1H6C0H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66227">
        <property type="protein sequence ID" value="SEG66227"/>
        <property type="gene ID" value="SAMN04489712_108174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="183" mass="20487" checksum="31714C8D76A393B7" modified="2017-01-18" version="1">MTSPTSRTSRNLRRRPPLGLPAGPAVLGIYLNDHLIGATGGTELAKRIAKAHRGTPAGPELDRLATEVAEDRRELMGMMTALGVPIRRYKVLIGWLGEKLGRLKPNGRLLRRSPLSSVIEFETMRLGVEGKRSAWSLLRRLAERDRRLDAARLDRLLERAERQSRLLEEMRVRAAEDLVGPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1S6</accession>
    <name>A0A1H6C1S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_108236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66909">
        <property type="protein sequence ID" value="SEG66909"/>
        <property type="gene ID" value="SAMN04489712_108236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="97"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG66909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="301" mass="32453" checksum="0AF0A3801B34BE13" modified="2017-01-18" version="1">MTADTQAAPGVDRAAGAPRRSAASRLVNRLGGGAVQAALALIALVWLVPTIGLFVASLRSSTDSGSSGWWTVFTKPAQLTLDNYGNLLDNDSITRGFVNTVMISVPTTVLVVIVASLAAYAFAWIEFPGRDWLFLGVVALLVVPVQVGLIPLIQLFGEVNLFGTVPGIVLFHTAFGLPFAIFLLRNYFAGIPRDLLEAARMDGGTEWTIFRRVIFPLGGPAIASLAIFQFLWVWNDLLIALIFGDEDSYPLTVAIQQQTRQFGSNLDVISSGAFLSLLVPLVVFFAFQRYFVQGVLAGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAP7</accession>
    <name>A0A1H6CAP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69725">
        <property type="protein sequence ID" value="SEG69725"/>
        <property type="gene ID" value="SAMN04489712_109110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="885"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG69725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="947" mass="101461" checksum="9DFAFB3CE9840056" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CB79</accession>
    <name>A0A1H6CB79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SnoaL-like polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70037">
        <property type="protein sequence ID" value="SEG70037"/>
        <property type="gene ID" value="SAMN04489712_109136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16720" checksum="F2556D1D8FC0B648" modified="2017-01-18" version="1">MDGDRMFELAQALAEAKSRQDVPAAMRLLHREMELEVPAFGTTVRGPAENEAALTWFFKAFPDYEVALDGHADNGETLVCWGTVRMTMHAAGLGLAPNGRRAELPVFIQFGFRDGLIAAERFLFDLSSLCAQSGVSTDEARERLFRRRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CK98</accession>
    <name>A0A1H6CK98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase RsbW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73419">
        <property type="protein sequence ID" value="SEG73419"/>
        <property type="gene ID" value="SAMN04489712_110108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="15"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="149" mass="16256" checksum="D2AC799C228F01C7" modified="2017-01-18" version="1">MNMRFSLALPRESLSIRVLRRVLGDALRGLGVAEDCIGDILVAASEACTNVIQHSHTPQDYEVLARVDGGVCELTVTDQGRGLTEESSAEPGDQAESGRGIKIMRALVDDVTFDTRPGQGTRVRLCKRLTWRDEALIRRLEGDLVHSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLH6</accession>
    <name>A0A1H6CLH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73515">
        <property type="protein sequence ID" value="SEG73515"/>
        <property type="gene ID" value="SAMN04489712_110119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="22"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="482" mass="51038" checksum="3C319ADF27FA6BB5" modified="2017-01-18" version="1">MTANEPRFHLPGMLIGGEWTPTGENGQAEVRAPYDGALVARVPAGGPRDVDRAVRAAAEALRRDDFPRSDRVRVLEQTAAALNDRRDHFARAIALESAKPLKTARVEAARAVETFAFAAAEARTFTGDVVPMDATPPGAHKTGFTLRVPVGVVAAISPFNFPLNLVAHKVAPAIAAGCPVVLKPASQTPVSALLLAELLDGLGVPAGWINVVTGGGGTVGDALATHDDVAYVTFTGSAEVGWAMAAKAPRKKVRLELGSNSPLIVDSPSDWQTAASKVSMAGFAHAGQSCISTQRVYVHRGIAGGFLDELLPRVEDLRLGDPMDEHTDVSCLITRDDTARMKEWVNEAVAGGAKLLTGGEAIDHGVFRPTVLEGPPAGTRVQCEEIFGPIITVTRYDDFDEALQMADESRYGLQAGVFTTDLGKALKAARSLHFGGVLINDVPTSRADQQPYGGVRDSGNTREGPAYAIQEMTETRLITLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLN8</accession>
    <name>A0A1H6CLN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73585">
        <property type="protein sequence ID" value="SEG73585"/>
        <property type="gene ID" value="SAMN04489712_110128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="407" mass="45572" checksum="C26BC460B0C56A80" modified="2017-01-18" version="1">MSTTESSPVVLPTHRTCPFDPPQEYALLREHEPVARLAFPDGKTGWLLTRHEDVRALLADERFSSDRARASSPVGRPLRPEEMEARPGMFLSKDPPEHTRYRRMVTRYFTVRRMRALAPRIEEIVTDRLDAMERSGPPVDLVRTFTLPIPSLVICELLGVPYADRDRFQRWTSTMLRLDVSAGEMLAARDALYAYMGDLVSAKREHPDDALLSSLIAANAAEGAQAPLTDEELTGIGLLLLVAGHETTANMLALGTYALLSHPAQSRMLREHPELAERAVEELLRYLSIAQFGAVRVALEDVEIAGRRIRAGETVVAALAAANRDPEQFPGPDELDLTREPSHHVAFGHGVHQCLGQQLARVEMQIALPALLRRFPTLRLAVPPERIPMRDDMFIYGVHELPLTWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLW3</accession>
    <name>A0A1H6CLW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73436">
        <property type="protein sequence ID" value="SEG73436"/>
        <property type="gene ID" value="SAMN04489712_110110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="539" mass="57974" checksum="930C9045DA989702" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMV6</accession>
    <name>A0A1H6CMV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74389">
        <property type="protein sequence ID" value="SEG74389"/>
        <property type="gene ID" value="SAMN04489712_110221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="177" mass="18722" checksum="E40FE78B714EEE19" modified="2017-01-18" version="1">MEQLRDAAAEGRIDLDELDSRLEQALKSKTHAELAALTADLPRPSSVESRPPLVLKGGMHGASRGPGRWEVPGQVIAHGGVGGVKIDFTRAACRLREVAVEAYGEMAGVTIVIPDGWAADTSGMDPGVGGLKDKTTPDRLPGTPLIRLTGSGGMAGVVIRHPNRRERRKLHSNPTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSE3</accession>
    <name>A0A1H6CSE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent peptidase ImmA, M78 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75949">
        <property type="protein sequence ID" value="SEG75949"/>
        <property type="gene ID" value="SAMN04489712_111101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="39165" checksum="DAFB965DDFDE8C7E" modified="2017-01-18" version="1">MGSLPGTTAQASMLVLARESRGMTQTSLAAAMSALAGERVSQGYVSKAEAGRLAVEGDRLALYAKALEYPAGVLCADPELSGIGIGLVHHRKKAALGAQALRRIHAQLALARLQVRALIGSEAQRRHRFERIAVSDLDTPAEAAQSLRKLWNLPTGPIPDLVGAIERAGGLVLVRDLETRDLDAVSQWDGREAPLFLLSAHAPADRFRFSLAHELGHIVMHPEPGTTAVQERQADEFASELLMPASDIAAELNPPLDLTRLLDLKRRWGVSMAALARKALTLAVISEWQYRNLMIEMSTLGYRTQEPGEIWREVPRVVPAAAQRLVHEHGLDRAADLVGVLPEEFVRLFSPEPGSAGLPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTV0</accession>
    <name>A0A1H6CTV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75965">
        <property type="protein sequence ID" value="SEG75965"/>
        <property type="gene ID" value="SAMN04489712_111103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="22589" checksum="46C1B5697B494086" modified="2017-01-18" version="1">MRGVAEVSPAAVDAAASALSAVTGFAASSRVRLQGTHAVLTYGLDRSEVERRRLVGLGAVTSPGALRLLLGLPIGVPVPMTRLGRGERAALRSAPRGVVRVEAGSVIRLAVPPVEVGLAMVPARSWRQGLELAGRFAPFCSRAMVLRRRPRDLDVLRMEADFYGIGVIVADEAEPEIVVPPQPFERRRFTAAGWLFLEETYQQVALAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUD1</accession>
    <name>A0A1H6CUD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76458">
        <property type="protein sequence ID" value="SEG76458"/>
        <property type="gene ID" value="SAMN04489712_111166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295227" evidence="2">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="174" mass="19385" checksum="99300E0E8578FD8D" modified="2017-01-18" version="1">MVKRLTTVGFASAVLGGALLAVPPALAMESASASVASVAGVPGGGVPKAGVPARRPVHRPVVRHVHVRAVQCRKCHRRHVVRHGRQVIHVHVHSKNKNINKNLNINRNDNHTRHHNLQHFGHHHHNRHHFGHHHNTRHHFGHHHHRRHHHGFGDGFGDWDGGFGDDGGWGDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CWM4</accession>
    <name>A0A1H6CWM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77248">
        <property type="protein sequence ID" value="SEG77248"/>
        <property type="gene ID" value="SAMN04489712_111270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG77248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="22715" checksum="378AFBEABA13461A" modified="2017-01-18" version="1">MAQQRAERADAVRNRRAVLHATERLLAEGGGEHVSLDRVAALAGVGKGTVFRRFGNRAGLLQALLEERSRELRDAITNGPPPLGPGAPVRERLLAFLDGLGAIAEDNAVLLSAHEQACAEDKYDDPSYQFWHRHLSVLFAEARPDLDADFLAHAVLAVFDGNLIRHMTPPDDPRRFTRSIQQMATALLDRGDHQAVIPQPIPEQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0A8</accession>
    <name>A0A1H6D0A8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_112118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78732">
        <property type="protein sequence ID" value="SEG78732"/>
        <property type="gene ID" value="SAMN04489712_112118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="212"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="364"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="478"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="841"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG78732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="966" mass="106192" checksum="9CBA9506000FE2A4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1N9</accession>
    <name>A0A1H6D1N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79251">
        <property type="protein sequence ID" value="SEG79251"/>
        <property type="gene ID" value="SAMN04489712_112189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="84" mass="8740" checksum="F66B6F441B6B85B7" modified="2017-01-18" version="1">MARGTIRYWAAARAAAGVEAEPYEAATLAEALHNALRARDAEFARVVGRSSFLIDGAPVGVRPHEGVLLPEGGTIEVLPPFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1U5</accession>
    <name>A0A1H6D1U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79311">
        <property type="protein sequence ID" value="SEG79311"/>
        <property type="gene ID" value="SAMN04489712_112197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="15822" checksum="A856B82B5671DF87" modified="2017-01-18" version="1">MIRARRVPSRSGARRGAAVALGAALLTAAALLGAWTVRSMDGPWGSPGRPGTLIVERCTAGPPAGGTPPTMRCVGTFTPDRSGPAVPGVSLSGPVRPWSAGDIRRARLPEGSRRAYTGGSGDWMVPLGFAAVLLLAGVTATGTGLGLWRGRPDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2F1</accession>
    <name>A0A1H6D2F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix of DDE superfamily endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78955">
        <property type="protein sequence ID" value="SEG78955"/>
        <property type="gene ID" value="SAMN04489712_112146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_4" evidence="1">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="86" mass="9692" checksum="F57773719FED2228" modified="2017-01-18" version="1">MLFYRAALDLSPRTRTFVADLIRGHRRRIGSRWRVLPPGRQALLVHLRRNETFSALAAAFGVGLATAHRYVTEVIGLLAELAPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2N0</accession>
    <name>A0A1H6D2N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79258">
        <property type="protein sequence ID" value="SEG79258"/>
        <property type="gene ID" value="SAMN04489712_112190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="24554" checksum="08A852DA59D3ECA1" modified="2017-01-18" version="1">MRKVLVVFLILLVGGVIAADRIGVRMVQNEIGERVAAQYDLPRRPEVTIHGFPFLTQAIGGEYDRIDVAVGDYTQQRVTVKDVRIEMRGVQAPLDQVTAGNTANVVVRAANASAVIPYELMRQYAPKQVTGIKANGPDLQVDLSGSLGGLPVSGTAVVSVEATEGGVRFTPRSVGTGGVQIPVNLVRQQLAWTVPVRDLPIGSRISRVEVTPDGVRVAATAQNVNLGALAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6I1</accession>
    <name>A0A1H6D6I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative zinc-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80325">
        <property type="protein sequence ID" value="SEG80325"/>
        <property type="gene ID" value="SAMN04489712_11362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="25193" checksum="C391C7FBB023F65D" modified="2017-01-18" version="1">MNTRHIDVGAYALDLLEEPDRRAFEAHLATCARCHEELAALRDVAAALDGMPLLESLPETPATDAAIVTDLVQRRAGLARRQRRSRVLLSAAAGVVLLAGGAGTGMALADGGDERPGPAPVVAAPPADGAQALLADGERRTATDPGTGVSGVVAWESKQWGARVALRLSKVRGPLECRLVAVSPGGRARVVTGWSVPDKGYGVPGSPAPLTVQGGVAVQPAQIERFEVRTDDGRTLLTVPVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7Q1</accession>
    <name>A0A1H6D7Q1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80556">
        <property type="protein sequence ID" value="SEG80556"/>
        <property type="gene ID" value="SAMN04489712_113102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="76" mass="8382" checksum="1580B7BDF465E7AF" modified="2017-01-18" version="1">MYNVRVSVSGEQGLVWQKSRRSNPSGNCVEMAQLPTGEIAVRNSRYPQGPVLVYTREEIEAFVGGAKDGDFDHLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8P9</accession>
    <name>A0A1H6D8P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81612">
        <property type="protein sequence ID" value="SEG81612"/>
        <property type="gene ID" value="SAMN04489712_11496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG81612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="37414" checksum="873EEF834605DB46" modified="2017-01-18" version="1">MRASRLLSLLLLLQTRGRMTARQLADELEVSLRTIYRDVESLSAAGVPVYADRGPDGGYQLLDGYRTRLTGLTTDEADTLFLTGIPGPATELGLGADLATAELKLLAALPPPLRTRAERVRERFHLDPQGWFHHREDTPHLAATAQAVWERHRITIRYQRWQHPREVTRTLEPLGLVLKAGRWYLIAQADDRIRTYRVARILDLHTLPERFDRPHDFDLAAYWRQWAERFEADSYPGTATIRLSPEGQRRAQFLLPPVMARAAHDNAGPPDPDGWIQATIPTESVRHAHSELLKLGTDAEVLAPPELRDLMTATACGLARLYQAPPTSDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8Z1</accession>
    <name>A0A1H6D8Z1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="3">DHNA-CoA synthase</shortName>
            <ecNumber evidence="3">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menB</name>
        <name evidence="4" type="ORF">SAMN04489712_11489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81584">
        <property type="protein sequence ID" value="SEG81584"/>
        <property type="gene ID" value="SAMN04489712_11489"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG81584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="299" mass="33491" checksum="0CCC5F177AE1BAB1" modified="2017-01-18" version="1">MVSELFDPSAWKEVEGFSFTDITYHRAVDQGTVRIAFDRPEVRNAFRPHTVDELYRALDHARMSSDVGCVLLTGNGPSPKDGEWAFCSGGDQRIRGRDGYRYAEGETGETIDPARTGRLHILEVQRLIRFMPKVVICVVPGWAAGGGHSLHVVSDLTLASREHARFKQTDADVGSFDGGFGSAYLARQVGQKFAREIFFLGDEYDAEAAHRMGMVNAVVPHADLERTALEWGRKINGKSPTAQRMLKFAFNLIDDGLVGQQVFAGETTRLAYMTDEAAEGRDSFLEKRDPDWSRFPWYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9K6</accession>
    <name>A0A1H6D9K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, NNP family, nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81503">
        <property type="protein sequence ID" value="SEG81503"/>
        <property type="gene ID" value="SAMN04489712_11472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG81503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="467" mass="49637" checksum="65702614677E9E14" modified="2017-01-18" version="1">MTVLTDPGRGRAAAAATPETKGGRWIDHWEPDDEGFWARTGRRVAARNLVFSILTEHLGFCVWLLWSIAVLNLNSVGMQLSVGQVLWLTTLPNLVGAAMRIPYTFAPARFGGRNWTIVSALLLVVPCGLFVYAIENPDIPYWALLVIAATTGLGGGNFASSMANITHFYPADRQGLPLGLNAAGGNLGTSVTQLAMPPLIVAFGLVAVGWVWMPFILLAAVCAYFFMNNLRQATSAYTLREMGAICRQPQTVVMSVLYIGTFGSFIGYSFSFGVLIKSQFPDIKGADFIWLGAFAGSLARPLGGWLADRFGGARVTAVDFLLMAAGIGAVAAAVRAGSWPLFLAAFLLVFVTTGIGNGSTYKMIPAIFKTKALERVDTADPAAVARAMATARRNAAAAIGITSSVGAFGGVLIQQSFRISLEETSGIGPALVGLTVFYGLCMLLTWAVYLRKVRVGDTRTSLAQAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDX3</accession>
    <name>A0A1H6DDX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83568">
        <property type="protein sequence ID" value="SEG83568"/>
        <property type="gene ID" value="SAMN04489712_11625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="157" mass="18242" checksum="82EB0BCFA75932B6" modified="2017-01-18" version="1">MVPAHHHVGVQTADLENCLAWYRDFLGAEQTWSLDRFSELTSRRLPGIRRLVEVRVGGTRFHLFERAGRGTEPAHPDTAQFQHLCMSVDSPRALREMRRHWNELYDSGRHTFAFSERPTEIVTDDQGVQSFYAYDVNGLEFEFTFIPDGIDDDQNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DG44</accession>
    <name>A0A1H6DG44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84447">
        <property type="protein sequence ID" value="SEG84447"/>
        <property type="gene ID" value="SAMN04489712_1175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="32141" checksum="9D317082C58B632A" modified="2017-01-18" version="1">MLGSQIELPVGDGVLSGLDFGGEGTTGVLLVHGSGHNAAVWTDVASRLVDRCHLVAVDLRGHGHSAPVSSTPEQYWRDLADVVAALEWDRPVLVGHSTGGYAVTAATAAGLVDAAALCVVDGMVLDDRDTAALAQAPWQGPEAAERLREMFRYGWRAGEQQMHAYVEQCVREAGTDWLNAGARPELVREVIRRTFLRRADGLWERRPTIEEIATVSAPDPHAVIYPSVDVYAHVRCPITFLLPDRGFYAQRRDEVQAVVDAAPGRELIEIAANHNVPMTQPADLATVIGELVRRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DH67</accession>
    <name>A0A1H6DH67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_116126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84015">
        <property type="protein sequence ID" value="SEG84015"/>
        <property type="gene ID" value="SAMN04489712_116126"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="29723" checksum="C624F0DF41DB766B" modified="2017-01-18" version="1">MPPVSGPPGTPAPNGRPLGRFAIMAVVNRTPDSFFDRGATFGFDAALAAVDRAVAEGADIVDIGGVKAGPGDEVDVTEELRRVVDVVTAVRERHPQVVISVDTWRAEVGQAVAEAGADLLNDTWGGVDPALAEVAAAHRIGLVCAHAGGLRPRTRPHRVGYDDVVADVIAHVTAEAERAVALGVPPEGVLIDPAHDFGKNTRHSLEITRRLGELVATGWPVLVAVSNKDFIGETLGQPVERRGVGTTAVLGVSAWLGARVFRVHDVAGARHALDAVAALAPEPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DII5</accession>
    <name>A0A1H6DII5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_117116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85024">
        <property type="protein sequence ID" value="SEG85024"/>
        <property type="gene ID" value="SAMN04489712_117116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="70" mass="7542" checksum="57B916E63E408D93" modified="2017-01-18" version="1">MALGGEVMPVTGSRRRSARAMPRHPRASGPLRRRRLAIRARSAFSARAERIPLGLGRPRATALRAAGAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIK1</accession>
    <name>A0A1H6DIK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_117112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85009">
        <property type="protein sequence ID" value="SEG85009"/>
        <property type="gene ID" value="SAMN04489712_117112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG85009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="24777" checksum="12507E28A60CB421" modified="2017-01-18" version="1">MNPLLELREIRAAYDGITALHGVDLRVGAGQVVALLGPNGAGKTTTLRVAAGVHPAESGRLLLGGRDLTGADPRDLARAGVCLIPEGRGVFPNLSVRDNLLMMTFTGRSREQVEEVAFARFPILAKRATQTAGTLSGGEQQMLALARGLATDPAVLLLDELSMGLAPLIVAELYEQVAEIARQGVAVLVVEQFAAAVLDIADHAAVMVRGRIERHGRPDDGLRTELSALYLGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLS6</accession>
    <name>A0A1H6DLS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86367">
        <property type="protein sequence ID" value="SEG86367"/>
        <property type="gene ID" value="SAMN04489712_11963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG86367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="26454" checksum="C10943F6BAB82B05" modified="2017-01-18" version="1">MAGDAAVTAAEKDAAAGEKAPDAPAEEITTSRSADAGWRWSDGYDPQRTRREIIDSALHLFEREGFDRTTLKQIVVGANLTKGAFYHHFRSKEDLLWHIQNEYLDTQIEAAREIVERGLDPVEQLRALIRLSLAGISTYRAHVAIFYQDRRHLTGDRLRSVTEKRDTLEAIFHETVQRGIDGGAFRREMNDRIITFGIFGLCASAFQWFNPDGSLGIDEVADQFCELVLVGLLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMF3</accession>
    <name>A0A1H6DMF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86389">
        <property type="protein sequence ID" value="SEG86389"/>
        <property type="gene ID" value="SAMN04489712_11968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040664">
        <property type="entry name" value="AFL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18067">
        <property type="entry name" value="Lipase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296041" evidence="1">
        <location>
            <begin position="26"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase_C" evidence="2">
        <location>
            <begin position="208"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="441" mass="47267" checksum="18C71A2615013985" modified="2017-01-18" version="1">MFRRLAAAVAAVLLVSTMVAGAAQAAPPQRHRPVIFVHGFSGSGAQFETQARRLASNGYPADLIEAHEYDSLFAENTREEVYAGLDARIARLRAKAGTDKVDLFAHSLGTTLMQAYLRSSPARAATVAHYVNLDGASSADQPGGVPTLAIWGEGPTTRAVGGARNVYLSDQAHTQTVTSPETFTEAYRFLTGQSPRTTAIVPQPPGHTRLSGRAVLFPANVGAEGASLEVYRVDPRTGQRKTRKPEATFKIAGDGSWGPFKANGSAYYEFAVVWGNVSTHHLYFQPFLRSDNFVRLLTSRPGEGLASQVETGDHHSALTINRQKEWWGDQGAAGDSLRINGQEVLNAANTPRTKRAIGIFAYDAGVDGVTDLTAPIPVFAAQPFITGIDFFMPASTKSSISLVSQQRGGGGRTDTLTVPAWPSSQDRISVQFNDHLQASQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DN49</accession>
    <name>A0A1H6DN49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_119138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86654">
        <property type="protein sequence ID" value="SEG86654"/>
        <property type="gene ID" value="SAMN04489712_119138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="88" mass="8842" checksum="08538C0C52052619" modified="2017-01-18" version="1">MTNLLELAANGVSLGLLYSIPGPGVSLSMEVVVFTAFPAAIIGGLDSLGGAVAGGLIVGMVQVLPAGCQDELSFLGLGLGDVDWRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNA4</accession>
    <name>A0A1H6DNA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86233">
        <property type="protein sequence ID" value="SEG86233"/>
        <property type="gene ID" value="SAMN04489712_11929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="298" mass="31143" checksum="3DA9D1042C6183C0" modified="2017-01-18" version="1">MTTPLSTDGACFGRVAVVTGAGRGLGAEYARRLARAGAAVVVNDLGVGLDGEADGTTPADEVVAEIRAAGGQAVASGHDVSSWKEAEQLVELAVDTFGDLDILVNNAGVLRDRTITRMTEAEWDSVIRVHLKGTFATTHHAANHWRERHAKHPERVGRLINTTSVSGLFGNVGQANYSAAKAGIAAMTIVASLELGRYGVTANCVSPGAATRMTATLGGDPDDPTRSPGFPAAVVEWLASRHSDGVTGRVFLTSGKRLSVAEGWEHGTPARPSEDLTELDATLRDLLATARPNADMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPX3</accession>
    <name>A0A1H6DPX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_120131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87437">
        <property type="protein sequence ID" value="SEG87437"/>
        <property type="gene ID" value="SAMN04489712_120131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041642">
        <property type="entry name" value="KstR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17925">
        <property type="entry name" value="TetR_C_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG87437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="22380" checksum="DE9A5FD4AA882689" modified="2017-01-18" version="1">MPRIASARPPAEPNSPEQHDRRRRILRAAVRIGSEKALERVQMHEVAKAAGVAIGTLYRYFPSKVHLFAAVMAAQVDHLDESVRPPAPGADLEGAVSELLVQASRDFLSRPVLAASMLQASNAANAATVADAIRIDATFRKILLRVLRIDTPTVQDVTLVRLLMQCWYGVLQLSLNGRVSMSDVEGDIRLACRLLLAPRSNAQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQ06</accession>
    <name>A0A1H6DQ06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_120123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87389">
        <property type="protein sequence ID" value="SEG87389"/>
        <property type="gene ID" value="SAMN04489712_120123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="219"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG87389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="366" mass="38237" checksum="4546B5689457A2C3" modified="2017-01-18" version="1">MDFTLGEELEAVQELARQIFGDHATHERLRTVEAGPGRIDETLWRELADAGLLGVALPEDVGGAGLGVAALCVLLEEQGRHVAPVPVWPTLVAALALAAYGTSAQWEELLPGVADGSRRLTVALEEFGPHDPAAPRCTAVVDGDGWRLTGVKAAVPAITGAGHVLVSASGEEGPGLFLVDAGADGLAWERTETTSRDLAGNLTLDRAPAQALEAGALGWTLDLARIALAALQVGVASGALGLAVSYLREREQFGRPLGSFQAVQHQLADSHIEIEATRVCLWQAVSSAATGEPVTRAALVAKWWADEGGLNVVHRIQHVHGGIGVDVDYPVHRYFLWGKQISGTLGGASADLDRLGALLAEEAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUE7</accession>
    <name>A0A1H6DUE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,4-dienoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_122105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88911">
        <property type="protein sequence ID" value="SEG88911"/>
        <property type="gene ID" value="SAMN04489712_122105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="10"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="313"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="42403" checksum="DFEC81467A7721B8" modified="2017-01-18" version="1">MNEQPTVPEVFAPAQLGPITLRNRTIKAATFEGMTKGALVTDDLIEFHRRHAAGGVGMTTVAYCAVAPEGRTERNQIWMRPEALPGLRRLTEAVHTEGAMVSAQIGHAGPVANARSNGLAALAPSGSISPLSLRRTRAATRADIERITRAHADAALLAIEAGFDAVEIHMGHNYFTSAFLSPRINKRQDEYGGSLANRAKVALGVARAVREAAGDRIAILAKLNMDDGVPGGLWLDESLQVAQWLERDGGVDALELTAGSSLLNPMYLFRGEAPVQEFAATFPQPQRLGIRLIGGKFIRAYPYQEAFLLESARQFRAALKMPLVLLGGITERATMDRAMAEGFQFVAMARALLREPDLINRIQKEPATRSLCIHCNKCMPTIYTGTHCVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUE9</accession>
    <name>A0A1H6DUE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88880">
        <property type="protein sequence ID" value="SEG88880"/>
        <property type="gene ID" value="SAMN04489712_12299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="101" mass="10841" checksum="8970D97BA9BAD9EF" modified="2017-01-18" version="1">MSGACGRASFVQPIAPADVAAILAEIVVGEPQGRHTDIAGPEPQDLVDMARRTHRARGREVKLVPTWSGLFGSEMAGNVLLPGEHARIAPTTFDAWLQDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXK6</accession>
    <name>A0A1H6DXK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90008">
        <property type="protein sequence ID" value="SEG90008"/>
        <property type="gene ID" value="SAMN04489712_12512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="101" mass="10989" checksum="4071D3CB0B9B5196" modified="2017-01-18" version="1">MPVFMISYRVADEGIAEVTEAIGKAFAAVEAQRPDGIRYAYLRRAEGNEFVALLDLAEGVENPLPGIAEARRLQETVAKWAVGPAPAPQPFKVIGDYRMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXQ3</accession>
    <name>A0A1H6DXQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90130">
        <property type="protein sequence ID" value="SEG90130"/>
        <property type="gene ID" value="SAMN04489712_12547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="6">
        <location>
            <begin position="18"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="7">
        <location>
            <begin position="110"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG90130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="36182" checksum="1C85F8148BB85C5D" modified="2017-01-18" version="1">MRKPVAVYTDVVDTDPGPGVELLEQAGFTVRFARTSAPADIVTAAEDADALLLGYAKVDRSLLDALPAVRIVATQSVGYDMVDLDACRERGIWVTNVPGAATEEVASHALAMTLALLRGLPQLDRDVRAGVWDGTRHELRRLSEVTVGVVGLGRIGRRYADYVRPLVGRVVGHDPVVTTVHGVESLELDELLACSDVVSLHLPLTDATRGLLDSRRLGLMRKGASIVNVSRAGLVDHRGLLQCLEEGRVSGAALDVLPQEPPEPNDPLVEHPRVLVTPHAAYLSAASSLDYVLEQARNVAEWRVQGRPISVVLEGHPTVPGRHSRPQPALDRAKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZS6</accession>
    <name>A0A1H6DZS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator, OmpR family, contains REC and winged-helix (WHTH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12747</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90817">
        <property type="protein sequence ID" value="SEG90817"/>
        <property type="gene ID" value="SAMN04489712_12747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="122"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="122"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG90817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="223" mass="24833" checksum="1D3F92D983E139C0" modified="2017-01-18" version="1">MTSVLLAEDDTSISEPLARALRREGYTVEVSPDGPQALERALGGGVDLIVLDLGLPELDGLEVARRVRSEGHGVPILILTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRGSTETPIVQGVRIDAESRRAWMGDQELQLTTKEFDLLRVLVRDAGKVVTREQIMREVWDTNWWGSTKTLDMHISWLRRKLGDDAASPRYITTVRGVGFRFERGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0B1</accession>
    <name>A0A1H6E0B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG90977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90977">
        <property type="protein sequence ID" value="SEG90977"/>
        <property type="gene ID" value="SAMN04489712_1285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="378" mass="40287" checksum="8B6843D9602C4C9B" modified="2017-01-18" version="1">MTPFNSTPPPSFGALPGADHDAQARKLSGNEFTAVCVVAALVGALGLLGFINSFAAVMRAAEPSFGRLAWTVPVGIDLGIAIFAALDIVLARLDMRVRWLRFIVWALTAATVYLNVAGEDTVFGQVAHALLPCLWVAAVEIAAHVVKVRAGIAAGTRMDRIRASRWLLAPVRTAALWRRMVLWEVRSYPTALDRERARLLVLTDLQDNYGAVAWRWKAPRRVRALYRLGELAPAPSDAPTAGEPTALADTDRPAIEAGTPELADTPADTAPDNGADTAPNTMTDTAPDSTPDNGDRTVSAIKRSRPSARRTGGKSAKRSDRLADKARALLTANPDMTGAELGRRLKVSERTGARLRARVLTTTNPTHEPAAAAAGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0S2</accession>
    <name>A0A1H6E0S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90525">
        <property type="protein sequence ID" value="SEG90525"/>
        <property type="gene ID" value="SAMN04489712_12663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="29734" checksum="3895F2715AA91F2C" modified="2017-01-18" version="1">MDQDATRLDDRTALVTGGAAGIGAGIATALARRGAAVVLVDNDETALDRTVAELTQGGCTALGVVADVRERSSTEMMRGAVGELSGGRLDVLVNNVGDHRPWGPFAQTSEEDWTAVYRLNFEHVLRVTRAFLPSMIERRSGSIINVSSVEGLRGVPNCTVYAALKAAVLNFTAGLSTEVGQYGVRVNAIAPDVTDTPQFPLHRLIGPEYHDQIPRWVPLGRFGTPEDHGDVAAFLASDAARWVTGQTIRVDGGTLASPGWFRRDEHRFTNVPRNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2C5</accession>
    <name>A0A1H6E2C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91742">
        <property type="protein sequence ID" value="SEG91742"/>
        <property type="gene ID" value="SAMN04489712_13037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="295" mass="33462" checksum="945D3805B124FE3F" modified="2017-01-18" version="1">MIQLISVDEVPPQPEPLPSIPVPQSLHGSHEAVRALRDTPGLLHVSAKTKDRALLIAQAIADECGRRGYAFGLRHEGEPGFQITNDDICFEFTLAEELERGEVMDSEKLAAAKYDWQRVPSSLGQVFSGRLILRLEAGYGSTFWADRKRWNLDQKLPAVFKEIADRTAAQLEARDRAQAERLRRRQAWEEAIPRAKRAYLDALNRDRLHRQAARSAEAEALRSYCARLKDAIDACDDPRQAQRIMEWTQWAQSEADRIDPLHDLDSLTYVTPATIEPSDFDEFMPPGMSAYRPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3F5</accession>
    <name>A0A1H6E3F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91536">
        <property type="protein sequence ID" value="SEG91536"/>
        <property type="gene ID" value="SAMN04489712_12952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG91536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="35837" checksum="22A712A86175CA0B" modified="2017-01-18" version="1">MSTALSDVTSPAPAGDGRRRPTTAGAWTAISRSTAEHVGLLGGLTVLFVLLTLWAPNFLTQSNLLDVARQLSFTGIIAFGMTLVIASGEIDISVGSAIAFNSALFGVLVVERSWPLWLAALAVCALGTLVGAGAGLVRAVLNVPSFIVTLALFSAFSGLALLITDSVPLPITSEDFARWGNGLLLGIPIPALVFIVVFAVFFVIAKRTTFGRSVYAVGGNPEAARLSGIPVTRVRATLFATTGLLAALSGLLQTAQLGAGNPTIGTGVEFAVITAVIIGGADLYGGRGSMVGTLLGVVFIAVLNNGMVLLGVNSYAQNVANGAIVLVTVLISTLRSSGRRSRRAKTATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3N3</accession>
    <name>A0A1H6E3N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91674">
        <property type="protein sequence ID" value="SEG91674"/>
        <property type="gene ID" value="SAMN04489712_13019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="47"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="705" mass="75424" checksum="8797A90633655437" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4E5</accession>
    <name>A0A1H6E4E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfite exporter TauE/SafE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92618">
        <property type="protein sequence ID" value="SEG92618"/>
        <property type="gene ID" value="SAMN04489712_13450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039447">
        <property type="entry name" value="UreH-like_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13386">
        <property type="entry name" value="DsbD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD_2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="34616" checksum="D5D2F38A760CDC91" modified="2017-01-18" version="1">MAGSAGGGTVALFAAGAGTGLLAGAASCASVQFGLLTGAVREAGRPLLPVIAFLTAKLAAHTVLGALLGAVGAAVAPGPRVRAALLVAAGVLLTVFALDLLGVPAARRLLRREGQSGHCAAPPAGRGPGVVGNPGAARSPGAFGRLRRPVALGAFTVLVPCGLTLSAELLAVGSRSALGGAAVMAGFVLGTAPVFALLGMALGRGLGALGGGLGAVAGAVVLVVAGWTLMSGLRLGGWLPSPGQARAVAEGSAEFVRTDGAGVQTITVWALDRGYRPSAIVARSGLPTVLVVRTRETRGCTRAFVIPGRDLERMLPVTGETRIPLGSPAPGRLRYTCASGHYPGGITFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4J3</accession>
    <name>A0A1H6E4J3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92153">
        <property type="protein sequence ID" value="SEG92153"/>
        <property type="gene ID" value="SAMN04489712_13240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="301" mass="33104" checksum="A14A72692E93C444" modified="2017-01-18" version="1">MTDAKPVTKAVVPAAGLGTRFLPATKATPKEMLPIVDKPAIQYVVEEAVSAGLTDVLMITGRSKRSIEDHFDRAYELEEALRAKGDDERLAAVRESSELATMHYVRQGDPKGLGHAVSCARRHVGDEPFAVLLGDDMIDERDALLTRMIETRQRFGGSVVALMEVEPDQVSAYGCAAIEPTDTDDIVRITDLVEKPPPEEAPSRWIIIGRYICDPAVFGVLERTPPGRGGEIQLTDALRTLAGTPAEQGGGVYGVLFRGRRYDTGNKLEYLRTLVQFASERPDLAPEFMPWLREFVDKHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5V1</accession>
    <name>A0A1H6E5V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_13328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92364">
        <property type="protein sequence ID" value="SEG92364"/>
        <property type="gene ID" value="SAMN04489712_13328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296625" evidence="3">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG92364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="332" mass="35473" checksum="BF593D8A71C60098" modified="2017-01-18" version="1">MRLRIGVAAALLAGLSGVLAAPGARAGTVRDDDATRAFTITDPRITESSGLAVSRQHQGVVYTHNDSGGSPLIFAIGPDGRTLATFTLAGATARDWEGMAIGEDEQGRPALFVADIGDNLGGAWPYVTVYRVPEPSRLRDQTLRATAFRLKYEDGPRNAETVMINPRTNRLYIASKLFSGALYEAPARLRATGFNTLRRVGRVPALATDGAFAPDGRSLVIRTYFSAQVYSFDDDAAEKTRPLRKVGLPGQEQGESIAYSADGRSLLAGSEGTRQPVWKVPLPDRARPTPTPSPAASGGREKDDEPNERNVGLVLVAGIALAVGYGILRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E639</accession>
    <name>A0A1H6E639_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Undecaprenyl-diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93162">
        <property type="protein sequence ID" value="SEG93162"/>
        <property type="gene ID" value="SAMN04489712_13731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="240"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="537" mass="56867" checksum="3B78535F0DB6F5FF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9T6</accession>
    <name>A0A1H6E9T6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pribosyltran domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93869">
        <property type="protein sequence ID" value="SEG93869"/>
        <property type="gene ID" value="SAMN04489712_14114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="19628" checksum="B05A0C9875809453" modified="2017-01-18" version="1">MTGDSQRIFQRRHLWRLTRAAYQAGVELLTQAASDRLGEIAAVVGIAQGGRAPAYAISARAQIPTVIVSARHNLSDDTYAQATGHVQCNLAPLRQFADRPGPFLVVDDICGTGATLAAVTDALTHIAVPGAVVCTATLCRNAGAPAGVPDLYVWDVADWVVFPWERLRGAGRMTPLPTPTKAQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EA61</accession>
    <name>A0A1H6EA61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93999">
        <property type="protein sequence ID" value="SEG93999"/>
        <property type="gene ID" value="SAMN04489712_14222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="26575" checksum="45F7C05310072A2E" modified="2017-01-18" version="1">MERYADRRVLVTGAASGIGRAVVLRLLAEGGRAVAVDVAKEGLEETARLAAEIGSRERLVTAVIDISDETAVNEGVAAAVAGLGGLDVLVNAAGMLRGARTHECELELWNRVIGINLTGTFLMTRAALPALLESGRGVVVNFSSTAAQFGHPYMAAYSASKGGILSFTHSIAQEYSRQGLRAVNILPGGISSGITDNIASLVPEDVDWNLFLKLNAAIGQGFGEPEHIAGVVAMVASDDGAFITGTEIRVDGGAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAB6</accession>
    <name>A0A1H6EAB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93874">
        <property type="protein sequence ID" value="SEG93874"/>
        <property type="gene ID" value="SAMN04489712_14116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="3"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="30274" checksum="7248292C68E96F2A" modified="2017-01-18" version="1">MEVPLLLVDGHNLAFRAAFGFPAPIRSRDKTRDLTAVFGFFALLRVAIRDEPAHPPEVIVVFDGENGSAARKAADADYKAQRADDEAAMKPIRALPDIKRGLDAYGLPWIEIDNAEADDVIATLTCSAPDRERLIMSMDKDFYQLLGPGVRMLNTAMHPGKRLIGPDEVRERHGVTPRQWPCFRALCGDPSDNIPGVRGIGEKTAAKLLAGGLHVRDLPTSGRLTGAKGQRILDTFPQVLAWRELIVARTDVPLPALPGGSPSPTLPAPAEVVDTLGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAD5</accession>
    <name>A0A1H6EAD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SHS2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000052">
        <property type="protein sequence ID" value="SEG94818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94818">
        <property type="protein sequence ID" value="SEG94818"/>
        <property type="gene ID" value="SAMN04489712_1524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG94818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14542" checksum="F3CF5D0A243ABB45" modified="2017-01-18" version="1">MTRSSAGHRTVPHTADMRIEAWAPSLEQCVAEAATAMVEGFADLSDAGPSTVREFRTESPDPEDLLVAVLDEIIYRMDAHGELPTSVTMHGPRVSFTMADTSQAVTIGAVPKAVSLNDLHIARGAEGWHCAVTLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAY5</accession>
    <name>A0A1H6EAY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase and inactivated derivatives, TnpA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000060">
        <property type="protein sequence ID" value="SEG95028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95028">
        <property type="protein sequence ID" value="SEG95028"/>
        <property type="gene ID" value="SAMN04489712_1601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002513">
        <property type="entry name" value="Tn3_Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01526">
        <property type="entry name" value="DDE_Tnp_Tn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DDE_Tnp_Tn3" evidence="6">
        <location>
            <begin position="158"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG95028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="565" mass="63832" checksum="2B0A1B612A7B85CC" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S2W2</accession>
    <name>A0A1H5S2W2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44935">
        <property type="protein sequence ID" value="SEF44935"/>
        <property type="gene ID" value="SAMN04489712_10158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014276">
        <property type="entry name" value="2-oxoglutarate_DH_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02927">
        <property type="entry name" value="SucB_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF44935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="489" mass="51330" checksum="63085405F1C69FD4" modified="2017-01-18" version="1">MPVSVTMPQLGESVTEGTVTRWLKKEGEHVATDEPLLEVSTDKVDTEIPSPASGVLTSITVAEDETVEVGAELAVISSEDEAPAAEAEPAAPAAEPAQEPEPAQEPRQEAPAQSAPPASWPPPAQAAQPAPQAPAQPAPQQAPAPQPQPQAAPQPQAAPEAPAPSGEGPYVTPLVRKLASEHGVDLSEVKGTGVGGRIRKQDVLEAAKAKEAAAKQAAAPAPAPAAAAPQAPSRPAPAHAAPSSEALQLRGKTEKMTRTRQTIARRMVESLQVSAQLTTVVEVDVTKIARLRERAKADFAAREGVKLSFMPFFAQAAVEALKVHPKLNAVINSETNEVTYYDVENLGIAVDVPERGLMVPVIHNAGQLNLAGLAQRIADLAERTRINKLSPDEVSGGTFTLTNTGSRGALFDTPILNQPQVAMLGTGSVVKRPAVIDDPDLGEVIAVRSMVYLALTYDHRLIDGADAARFLGTIKQRLEEGNFESELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SEE1</accession>
    <name>A0A1H5SEE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48790">
        <property type="protein sequence ID" value="SEF48790"/>
        <property type="gene ID" value="SAMN04489712_101170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF48790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="601" mass="61706" checksum="AEF5BB14B7D1C0C6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SIV0</accession>
    <name>A0A1H5SIV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-methylhydantoinase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50360">
        <property type="protein sequence ID" value="SEF50360"/>
        <property type="gene ID" value="SAMN04489712_101224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase_B" evidence="1">
        <location>
            <begin position="4"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF50360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="624" mass="67710" checksum="322AAEB5D1C37147" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SKZ8</accession>
    <name>A0A1H5SKZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murF</name>
        <name evidence="11" type="ORF">SAMN04489712_101260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51293">
        <property type="protein sequence ID" value="SEF51293"/>
        <property type="gene ID" value="SAMN04489712_101260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="110"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="321"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF51293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="477" mass="47963" checksum="1235690C10406F3D" modified="2017-01-18" version="1">MIPLALTEIAQITGGEVAPGAGGVVAAGPVVIDSRAVTPGALFVALRGERADGRHFAAAAVAAGAAGVLAERPLDDPGLPAVVVDDAVAALGGLARGVLARLPQVTVVGVTGSAGKTSTKDLIAQVLERHGPTVAAKGSFNNEIGHPLTVLRADSGTRHLVLEMGARGVGHIAYLCRIAPPRIGAVLNVGSAHIGEFGGREMIAKAKGELVEALPPDGAAVLNADDPLVRAMAARTDAEVVTFGRAADADVRAVDESLDDRGRARFTLVTPQGAVPVALRLHGSHAVGNALAAAAVALRAGMAPEAIAAALSQAGPVSRWRMEVEERPDGVTIVNDAYNANPESMRAALDAVAHMARAAGGEGRAFAALGEMAELGARSVAEHEKIGQHVARSGFAGLVAVGAAAAPLLDGARQVGSWTGECVQVDDVGAAVTALSERLRPRDVVLVKGSRVAGMERVAQGLLAAAGGRGADGGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SSH0</accession>
    <name>A0A1H5SSH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52761">
        <property type="protein sequence ID" value="SEF52761"/>
        <property type="gene ID" value="SAMN04489712_101319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF52761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="16873" checksum="9881AB056FEDDD31" modified="2017-01-18" version="1">MGRPHNFRPDPGRARRAALRGALTAACGAALLLGGCSAGGSGQNAGGDDPPGVTVAGLEDLASKAGCTLQSQTKAEELRQGACQTSKGRYTLVTFTTEEGQGNWLREAKPWGGTYLVGPRWVAVGTEQTLQTLRQDLGGEIQAGDDHGQGGKHEDGNHGGHTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SVF5</accession>
    <name>A0A1H5SVF5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Proline iminopeptidase</fullName>
            <shortName evidence="4">PIP</shortName>
            <ecNumber evidence="4 6">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 6">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 6">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="4 6"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54500">
        <property type="protein sequence ID" value="SEF54500"/>
        <property type="gene ID" value="SAMN04489712_101379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PTHR43722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="40"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF54500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="36718" checksum="FB7EA7CAD2F27B0F" modified="2017-01-18" version="1">MELRTLYPPIEPHDCGLLDVGDGNHIYWEVCGNPDGKPAVMVHGGPGGGCTAEHRRQFDPQAYRIVLFDQRNCGRSKPHAADPQVSLETNTTWHLVADMERLREHLGIDRWLVFGGSWGSTLSLAYAQEHPDRVTELVLRGIFMLRPFELYWFYQEGASLLFPDAWEKYVAPIPEDEREDLIAAFGARLESGDRQERIAAARAWAQWEASALTLRPNPGLVDHFGEPDYAVAFARIENHYFRHEGFFEEEQLLRNVERIRHIPAVIVQGRYDVCTPPATAWDLHRAWPEAEFHMVEDAGHSFDEPGILHRLIEATDRFARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SWK0</accession>
    <name>A0A1H5SWK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside 2-deoxyribosyltransferase like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54963">
        <property type="protein sequence ID" value="SEF54963"/>
        <property type="gene ID" value="SAMN04489712_101394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039470">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15891">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF54963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="381" mass="41678" checksum="6116C7D662536EAE" modified="2017-01-18" version="1">MDSEVVVVYAREEPPQSWDAAVFLAGPTPRGPGAESWRPAAVDRLRGCWAGSGRLVVFVPEHRHGVHDDYRGQVDWEERCLHLSDEIVFWIPRDLRTMPAFTTNVEWGMWHDSGRVVFGAPPQAPKNDYLRHYAGKFGVPVSTTLDGVIAAALDRIGGGAPRTGGEREVPLLIWRLDGFQRWYAAQRGAGNVLRGARLLWHAGPLWGMRVAVEVAAEGRVKDNEVVFSRPDISVVVLHRPGPTLDETVVVLVREFRSAAATADGMVHELPGGSGPADPLRNAVEEVTEETGLVLDPARLHPHGARQVNATMSAHRAHLFSAEITGEELAAIRGTGPHGQVDLGERTYVEAATFAEIRRARLVDWATLGMIAEALTTVRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T9E2</accession>
    <name>A0A1H5T9E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterodimeric methylmalonyl-CoA mutase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59364">
        <property type="protein sequence ID" value="SEF59364"/>
        <property type="gene ID" value="SAMN04489712_101533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF59364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="623" mass="65301" checksum="6427ED83D4FDCDAC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TE82</accession>
    <name>A0A1H5TE82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kynurenine formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60307">
        <property type="protein sequence ID" value="SEF60307"/>
        <property type="gene ID" value="SAMN04489712_101560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF60307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="30324" checksum="3C0A9F7FFED3EBBC" modified="2017-01-18" version="1">MTTDTTTRAGQGRDPLLEAVRGGVRVHDLGRPLYIGMPQSPNHPAYWHTLPRRHGDMVRPDGGSAANDMLVMGTHVGTHIDALAHVSHDGRLFGGADAAQAGAGGRYLEHGVHTIEPMVRRGVLLDVPAALGVDGCDPGYEITPADLERAAGRQGTEVGAGDVVLVRSGWGRLFDDPDRERYIGAASGVPGVGEAGARWLADRGVHAAGADTIAFECLPPGKGHSVLPAHRVLLVESGIYIIETLNLEEVAAAGAHEFTFVLSPLRLTGATGSPVRPLALVGRPQGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TGQ7</accession>
    <name>A0A1H5TGQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61261">
        <property type="protein sequence ID" value="SEF61261"/>
        <property type="gene ID" value="SAMN04489712_101589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF61261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="217" mass="21693" checksum="18035F41C74073FA" modified="2017-01-18" version="1">MCRARPAAAGDPPRRRRGAAPPSGGLIGGNVRVKTIAAGTGAAAVLLLPAPSALAAAATAAADIDIDIDIEPGYAMAEETVTVVGTCDRTGDDTVRIVSQALNGKSVRVDSEGRYRVPVTVRRVGEGTYTVTAICEPSMTSASDRFRVRDGISGGGFSGSTESEQVDYPRGGAGTGGGGTAENTGGGRPSAGSTLLLGTVIAAVIGGVVLVRRRGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TMW6</accession>
    <name>A0A1H5TMW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64116">
        <property type="protein sequence ID" value="SEF64116"/>
        <property type="gene ID" value="SAMN04489712_101683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="40"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF64116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="213" mass="22608" checksum="B98CC032724E3780" modified="2017-01-18" version="1">MARRHPLFARYYARASPRWEGRMAVHRHSLSAGLAGRVIEIGAGTGAGFAHYPPEVTAVLAVEPEPHLRRLAQAAARRAPVPIEVIDGVAERLPADDASYDAVVSSLVLCSVPDQAVALAEIARVLRPGGQLRFFEHVAAATPGRRRIQRALDATVWPRLGGGCHTGRDTAAAMEQAGFTITRLQRLTSADTGIPFPAAPQILGTATAPAAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TT10</accession>
    <name>A0A1H5TT10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65910">
        <property type="protein sequence ID" value="SEF65910"/>
        <property type="gene ID" value="SAMN04489712_101734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF65910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="25374" checksum="1AC603528DC6B5DC" modified="2017-01-18" version="1">MIVTGGGTGIGRATARAFADRGDGVLVVGRTESALIETAKDHDGIRVLTADVTEPDGPRLVVDAALREFGRIDVLVNNAAALGYRPLAHVDRDLVDLQLGTNLIAPILLTRCALDALEAAGGTVVNVSTAGSLGMRSWPDNGVYGAAKVALDFLTRTWAVELAPRGIRVVAVAPGVIDTRSAPRMGLSEEAYDGFLEQIAARTPLGRVGTPEEIAWWITQLTLPQAAYLTGAVVPVDGGLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TU37</accession>
    <name>A0A1H5TU37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65507">
        <property type="protein sequence ID" value="SEF65507"/>
        <property type="gene ID" value="SAMN04489712_101723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF65507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="309" mass="32735" checksum="A9F605D91879D14B" modified="2017-01-18" version="1">MGSQSGVAMVLGATGFVGGAVDEAFTAAGYDVVRVARNRPARLPETSFVPLDVATASPAAIARIVTRWRPEVLVNATGGWLASEEANRLHHETLVENLVAGLALTDAPPRLVQVGSIHEYGPVSSGAPIHEGISPRPLTPYARTKLAGSETILRATRKKLVDGVVLRSVNLCGPHVTPASFLGFVLSELRALPPRQRLTLRIADDRRDFLDVRDLADAVVRAARAPVSGRVVNVGRGVAVAVREMVSLLVAVAGFPPEVLDLDGDGEPVASRGGGWTMADIRLAGELLGWAPRIGLHESVRDMWEAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TX87</accession>
    <name>A0A1H5TX87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted ester cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67379">
        <property type="protein sequence ID" value="SEF67379"/>
        <property type="gene ID" value="SAMN04489712_101779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF67379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="14531" checksum="CCF45D7A26D0BB06" modified="2017-01-18" version="1">MSEDTKQELFERALAVVDAWNRLDFDALRELVDENVEVVHQNRGVAARGRDLMFQTIENMSKAFPDRSIGETTRWAVSGNTVFRETVWQGTAAMDVPGFGKTGEHCKLNVLSLMTFKDGRLVEWCDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5USN2</accession>
    <name>A0A1H5USN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Superinfection immunity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78095">
        <property type="protein sequence ID" value="SEF78095"/>
        <property type="gene ID" value="SAMN04489712_1026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016410">
        <property type="entry name" value="Phage_imm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14373">
        <property type="entry name" value="Imm_superinfect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF78095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="83" mass="9157" checksum="2709964836198E7D" modified="2017-01-18" version="1">MNSYESSPWFWLLIIGGLATLAVLPTLVAMLRRVDSLTTIILFNTIGCATFVGWPAALVLAFAMPRRTQKTGLPFSTRQFPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UW90</accession>
    <name>A0A1H5UW90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79432">
        <property type="protein sequence ID" value="SEF79432"/>
        <property type="gene ID" value="SAMN04489712_10264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="72"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF79432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="35944" checksum="03B8D2C2C307A219" modified="2017-01-18" version="1">MSAIADRNGRARSLPADRPATVSLPRPAPPDGEPPLTAEEVAELGDRLRANISAAVRTPARVLEVVLATVLAGGHLLVEDHPGVGKTQLARTLARSLDGRFSRVQATVDLLPADIIGANVWQADSGAFEFRPGPVFANVLLVDEINRATPKTQSGLLEAMQERQVTVDGDSRPIPPPFVVIATQNPSAGYDGTYPLPPAQLDRFLSVVSLGYPTPEQEMSLLRAGPEPAVTAVTDPARLLAAQRAVAAVHASDALLRYVVELLTATRDHPLAAVGASPRSGLLLLAAARAVAALDGRAFALPDDVQAMARPVLTHRIQPAGVGSADVQAEVVEDVLGRVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V2F7</accession>
    <name>A0A1H5V2F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81575">
        <property type="protein sequence ID" value="SEF81575"/>
        <property type="gene ID" value="SAMN04489712_102138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF81575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="41945" checksum="2EDB96F68306FEB7" modified="2017-01-18" version="1">MNGVRHAARYEARLLWSGNPGLYALLQAARHTAPIQRFPKLGWVVTDPLLARRVLNDSAHFGMAGEGGVGHLWSQLFGEEMAQFFGGARHTEVRTRARDLFTEEGARTLVERCQGAYHQALAERLAAGGTVDVADATRVLAGRTVADLLGLRLDTPSDDAYREIFAAGERLAALAMGTTASTVLPAGVLRQARAIVTDITRGVEEGYRTAGPDTILGRCRQMGLGLPMTRGLATLLAIAGTETGASGTSRTVALLHDTGQQAALLADPGLMANTVREGLRVATPAPVIGRSVTRDAVVGGRRLRAGERVLLLTYLADNGAGPFDIRREYVSQTRQLWFGAGRHLCLGAAVARTQVARMLETLTAAGPYQIVARRPARRVLVPTYASLRVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V4R7</accession>
    <name>A0A1H5V4R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholest-4-en-3-one 26-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81758">
        <property type="protein sequence ID" value="SEF81758"/>
        <property type="gene ID" value="SAMN04489712_102145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF81758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="47178" checksum="1075B485CA1A2119" modified="2017-01-18" version="1">MAHLTGAPEINLVDPDSYERDGIPHAQLTWLREHAPVFRHEGDPERGWPAFWAVTRHADIVHVSRHPELFSSFTRLALFDELPDEELALNQLMMLNQDPPDHTRRRGIVNRGFTPRAIEALTGHIRDICRRLVAEVAERGPEADFVRDLAAPLPLQVICELLGAPVEDRDKIFEWSNTMIGGDDPDFRKGAGVDPETVAEEGRKAAMAIYAYANELAARRRAEPRDDIVTKLLQPGPDGEVLDGDEFELFVLLLMVAGNETTRNAASGGMRALLEHPGQWERLKADPGLVRTTADEIVRWVTPVNLFRRTATRDTELGGERIREGDKVVVFYASANRDERVFDDPFTFDVGRDPNPHLGFGGGGPHYCLGVHLARLELRVLFETLLDTMPNMELTGNVRRLRSYFINGVKEMPVRVAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V861</accession>
    <name>A0A1H5V861_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83549">
        <property type="protein sequence ID" value="SEF83549"/>
        <property type="gene ID" value="SAMN04489712_102211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF83549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="7080" checksum="A8138E53E0BD9CF9" modified="2017-01-18" version="1">MDEQDEHTDVHTDVGAYALGLLEEDDRRAFEAHLAGCAACRAELAGLAGVADALRDVRDERTGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V8R1</accession>
    <name>A0A1H5V8R1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">bioB</name>
        <name evidence="16" type="ORF">SAMN04489712_102197</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83151">
        <property type="protein sequence ID" value="SEF83151"/>
        <property type="gene ID" value="SAMN04489712_102197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="52"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SEF83151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="36277" checksum="9860DC4C13D487AB" modified="2017-01-18" version="1">MTDILEVARRQVLQEGKGLNAEQALQCLTLPDDRLEDLLELAHEVRMRWCGPEVEVEGIVSLKTGGCPEDCHFCSQSGQFTSPVRAVWLNIPELVEAAKETAKTGATEFCIVAAVRGPDERLMSQVREGIKAINDAVEINIACSLGMLTQEQTDELVAMGVHRYNHNLETARSHFSNVVTTHSWQERWDTCLMVKEAGMELCCGGIIGMGETVEQRAEFAGQLAELEPDEVPLNFLTPRPGTPFERFGLVEGAEALKTIGTFRLALPRTILRYAGGRELTLGDLGTRSGMLGGINAIIVGNYLTTLGRPAEQDLDLLSELQMPIKALSQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VF37</accession>
    <name>A0A1H5VF37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA carboxylase epsilon subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85391">
        <property type="protein sequence ID" value="SEF85391"/>
        <property type="gene ID" value="SAMN04489712_102278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF85391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="91" mass="9994" checksum="53AEF4E590BDDACD" modified="2017-01-18" version="1">MDEPVTEPLVVRVLRGSPSDEELAALLAVLAALPPARPAARPTARRAGWDRDRPRFRAAHSWRHDTSGSHSWRHGTAGSHSWRHGTSGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VLS3</accession>
    <name>A0A1H5VLS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88160">
        <property type="protein sequence ID" value="SEF88160"/>
        <property type="gene ID" value="SAMN04489712_102369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF88160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="352" mass="38600" checksum="E15521ABFCA93BB7" modified="2017-01-18" version="1">MVTAEERRWRQERTRLNRRRAELGDAADKLYPGAPRVGSTALLCRPEWIPADPLPLESVRLLWDEDPTPPAVTGAEAVLPDGYRTYSEAMGALAAPAVFENRPSYRLLAADLTGHGTARDSHGDLRAGGPMLRLAGACYFEGVDVGEAVAHELAAEAEGLPLRTLVGDPCELARRAALPAITTVTIRRRARDFVLHWRDPAKVVHAGGLHQVMPVGVFQPVTGDHADDLNLWRCMAREFSEEFLGTGEEYGPGFSYEDWPFFRRLEAARRAGTVRVHCLGLGTDPLTLAVDVLTAVVIDDEVFEDLFGGLVRVNTEGRVTMAPFDGRTPRPMQPAGAAALELAWRHRNALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VPA7</accession>
    <name>A0A1H5VPA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, FadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89050">
        <property type="protein sequence ID" value="SEF89050"/>
        <property type="gene ID" value="SAMN04489712_102399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF89050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="27321" checksum="4E1C6CBE100AB700" modified="2017-01-18" version="1">MLSEIDDQVQGPPEEAAGDPLAAVLRPVRAGNAFEETVERLLQIIKLGAVAHGERLPPERELAPRLGVSRVTLREAIRALQQEGYVESRRGRSGGTFVTYRTPRPRSGDLARVAEGQVEQLTDALTYRMAVETGAAQQLASAGLTEAQSARLRRALAEANSAGETDYRRLDARFHLTIAELTGSALLSAACADARMRVTDLLNAIPVLQRNIEHSAVQHEAIVAAILVGDPEAARRAVVEHLEGTAALLRGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VTN5</accession>
    <name>A0A1H5VTN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89917">
        <property type="protein sequence ID" value="SEF89917"/>
        <property type="gene ID" value="SAMN04489712_102431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="191"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF89917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="29884" checksum="DE867708B0EE37C7" modified="2017-01-18" version="1">MAVKGAMDSLWSVRRPVGELRPGDHAWLAFGGEDEHRHVVGAFVRTGLAEGDRVVLLGGPQGAEMAGGDQVAVVGLGDSGAVDPRVLARALASEISEADRSGCRAVRIVTDLTWVLRRPGGLELALDCERHIERVIGPSTSAIAICQLDRRACAPGELAALEEAHAVAVTADPDFADSVLRIDRTFHPAGLALGGELDASRHAVFSQALSSVLARADGDPVHLDLAELEFIDLGALSMLAGAATRRPGHGPLVLDRMSARLRSVVEAVGWDMLPGLRLGAPHPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VWQ9</accession>
    <name>A0A1H5VWQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90997">
        <property type="protein sequence ID" value="SEF90997"/>
        <property type="gene ID" value="SAMN04489712_102469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF90997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="28190" checksum="22DF23A574AC591E" modified="2017-01-18" version="1">MTVQLYARDVGGGTPLVLLHAFPLSSAMWLAQREGLGGRFRVITPDLRGFGGSVLGEDEPSVDVMADDVARMLRVKGIDRAVIGGLSMGGYVAMALCRRHPDRVLGLVLAGTKASADTEQARDVRLRQAERLEHEGGTRVLVDEVLPFLVGPTTMRQRALVYGRVRGLVQAAPALAAAWAQRAMAARGDSFETLRGTRAPALVMVGDEDELSTRTDARAMAEALPNAELQVIPRAGHLSAVEQPDLFNQAVAEFVAALARTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VY82</accession>
    <name>A0A1H5VY82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91946">
        <property type="protein sequence ID" value="SEF91946"/>
        <property type="gene ID" value="SAMN04489712_102505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018702">
        <property type="entry name" value="DUF2207_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09972">
        <property type="entry name" value="DUF2207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009287726" evidence="2">
        <location>
            <begin position="29"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF91946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="402" mass="42543" checksum="E2C8E3EA7DBC79BC" modified="2017-01-18" version="1">MRDMLWAMVVAIGAPPAAAFLGPPASLASPASAAVTASATAIPPTAPRIARVPAAPQVTTFPAAAAGRESAEERLPGESIPTYDVVLTIRPDGVLHVRETITYDFRGREHGIVRRVPYRVDNRLYDIRDVRASSSTGAPARVKATKMLHEVRISVGGGHRTVSGRQAYVIEYDVTGVLTSLPDGHAELHWDAIGTGWDVPIGEVSVRVETPVRPLGVSCRAGEKRRAGLSGDDAGLTRCGWDRDGLHAVDFTQGGLRPHESVLIKARLPEGAVQVPPPRYARPHFAASWPGYVALGLGLAAALTLWLPRSGRRAAALLRWRPGARSPRWRPGRRTGTALVAAGTALVALDLADDVVAHGVWAASMGDPALVGLGLLTPGMILFLAGRRGGAAEREASQDQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W681</accession>
    <name>A0A1H5W681_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="5" type="ORF">SAMN04489712_102602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94920">
        <property type="protein sequence ID" value="SEF94920"/>
        <property type="gene ID" value="SAMN04489712_102602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF94920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="162" mass="18453" checksum="C999B24C22349759" modified="2017-01-18" version="1">MPRETGRKLVAQNKRARYDYHLDDTWEAGLVLTGTEVKALRAGRASLADGYARVKDGEVWLEGVHIPEYLQGTWTNHAPRRPRKLLLHRREIQKIIVKTKEPGVTIVPLSLYFRDGKAKVEIALARGKKSYDKRQAIAKREAGREMERARSARLRARTGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X0B2</accession>
    <name>A0A1H5X0B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05234">
        <property type="protein sequence ID" value="SEG05234"/>
        <property type="gene ID" value="SAMN04489712_10337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG05234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="22994" checksum="E7A0B8E6E816721D" modified="2017-01-18" version="1">MGIRVVVVDAHTLSRHGLAWIAERQPDVEVVGEAGSLAQAVSRVAARSPQVVTVAARLPDGDGLGLVRALRARDPELGAVVLGPPGDDEVLFAAMDAGASAYVTTTAPAAEIAAAIRHAAVAPGSFTSAGLARALARRRTGGLLSPRERQVLTLLMEGRSIAAIASTMHLSHSTAKTYTARLYEKLGAANRTQAVMAALRLGLVRHDLPVPPPRLPDVAGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X3W2</accession>
    <name>A0A1H5X3W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05976">
        <property type="protein sequence ID" value="SEG05976"/>
        <property type="gene ID" value="SAMN04489712_10362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG05976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="34823" checksum="7A1DA362807A6166" modified="2017-01-18" version="1">MSETNSGSSGIAGHIVRRARPPRRGTAIVAAVAAAAGGLAGCGGAAAATITRLAVGAPGPDAYTLVANTDSAGTTPRRRAGGQAEGDTPGLYGGTRNVATCDPAKLLAFLRSHPAKAKAWAAVHRIKVADLPRYVGRLTPVILRVDTLVTNHGYRAGRATSLPAVLQAGVAVLVDEYGKPVVKCNCGNPLTGPDREIDPRDAKYTGSSWRGFSDRKVTTIRPRARGKGALSSITLVNPGATMSFNRPLGTTGEQDGPPAALPPGESASPTGGPTQEPSPTGVPTDAPYSPGPGDGGPTPEPGITEPGTGPGEPGTGDGRPEAPAEPTPNGYASSPPPEAADGPGGVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X8Q4</accession>
    <name>A0A1H5X8Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07810">
        <property type="protein sequence ID" value="SEG07810"/>
        <property type="gene ID" value="SAMN04489712_103128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="100"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG07810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="511" mass="56988" checksum="85C35D3F3239946E" modified="2017-01-18" version="1">MVADDQVPPSRIPSDSSRDSEAGAGWECGRAGSFVDLLPSAGQVRQFSWRHPGVLWRSRNDWVAKAFGDPSNAVRRAWVRALRERDPGLSFTMRREAKEFSFLLLGDTGEGDRSQYAVVPPMLAVGKDTDFMVVCSDVIYPGGDAADYEAKFFRPYTGYPAPIYAIPGNHDWYDGLRGFMRAFCDLGGAHDPSWRGPLGRAARLLWRRPGPADDGELAAARERYRGEEGQRAFQPGPYWAIDSPSLRVIGIDTGITGGIDRDQAAWLREVSAGPKPKLLLTGKPLIVDDQVRPGPIEGERGTVHDIVADPAHHYVAVIGGDIHNYQRYSRTLEDGRTIEYVVAGGGGAFMHATHTIPKTTVVPEDAFRCYPLRGDSLSRYSRLYAQWLRMKWLALDPGEAAAAVADRLDMGTTRASARDLRPSRRARLVAALLGVPYRHRPRPRLLRLPVRRLPQRFRSEFADWDRPPFFKSFLRLDVTGDTLTISCYGVSGCGEQEDRPPCEDRVTIRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XCP8</accession>
    <name>A0A1H5XCP8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xaa-Pro dipeptidyl-peptidase</fullName>
            <ecNumber evidence="3">3.4.14.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">X-prolyl-dipeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_103196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes Xaa-Pro-|- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-|-p-nitroanilide and (sequentially) Tyr-Pro-|-Phe-Pro-|-Gly-Pro-|-Ile.</text>
            <dbReference type="EC" id="3.4.14.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.11" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09538">
        <property type="protein sequence ID" value="SEG09538"/>
        <property type="gene ID" value="SAMN04489712_103196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008252">
        <property type="entry name" value="Pept_S15_Xpro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00923">
        <property type="entry name" value="LACTOPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289283" description="Xaa-Pro dipeptidyl-peptidase" evidence="9">
        <location>
            <begin position="34"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="10">
        <location>
            <begin position="360"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG09538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="655" mass="71419" checksum="059D477122DCF723" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XSV4</accession>
    <name>A0A1H5XSV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="4" type="ORF">SAMN04489712_103391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14742">
        <property type="protein sequence ID" value="SEG14742"/>
        <property type="gene ID" value="SAMN04489712_103391"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG14742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9298" checksum="B3C92D194C3912E9" modified="2017-01-18" version="1">MPAATEQEILAGLGEIVEEIVGIPAGEVTPDKNFIDDLDIDSLSMVEIAVAAQDRFGVEIPDDELRNLKTVKDVIDYVQGLTGATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y0I7</accession>
    <name>A0A1H5Y0I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17130">
        <property type="protein sequence ID" value="SEG17130"/>
        <property type="gene ID" value="SAMN04489712_103485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="44"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28921" checksum="D0FA9692DAC0272D" modified="2017-01-18" version="1">MKAAVAGVFDRSADTYEQLGPEYFGPMGRALAARAAPRPGERVLDLGCGRGHCLVPLAEAVGPQGRVVGIDLAPGMVAATADDARRRGLSQVDVRVGDAAEPAVEPGSFDLVTAGFVIFFMPDPAAAAGAWLRALRPGGRLAISTFNGQDPNYEHLMKVVGAFLPQQQDRPRFELFRTAESVTAVLDEVGFQDVEHEHVTFETRFTGPDQWWEWIGSHGGRATLERLPEDRVEDARAAAYEAMEAARTPDGALAIYTEVRYTTARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y262</accession>
    <name>A0A1H5Y262_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG18013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG18013">
        <property type="protein sequence ID" value="SEG18013"/>
        <property type="gene ID" value="SAMN04489712_103518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290068" evidence="1">
        <location>
            <begin position="29"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG18013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="196" mass="19195" checksum="DE40A4D4DCF89DF2" modified="2017-01-18" version="1">MRRRTLRTAVVAATATAAVGLTALPSHAIPVTVSGSASSGAYTATSGTVTFTLSSGALATCSSSAGGGTMPNGYSASGNNIGGFAVTTWTGCPVTQSGTAAINVVGGTASTVQVTVTNLTLTYAVPGCTMTATGGAPGTYTNGSAVLNIDPTAPNPQNVQLVVISVTGCFGLVNPGQRLRYAGSYTLTPGTIQLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YL05</accession>
    <name>A0A1H5YL05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24275">
        <property type="protein sequence ID" value="SEG24275"/>
        <property type="gene ID" value="SAMN04489712_10450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG24275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="30" mass="3418" checksum="AD74C73452CC7E8E" modified="2017-01-18" version="1">MDEDETAGRRRIRANPEAATTFRRTVNLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YT46</accession>
    <name>A0A1H5YT46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27363">
        <property type="protein sequence ID" value="SEG27363"/>
        <property type="gene ID" value="SAMN04489712_104174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG27363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="41" mass="4266" checksum="29B893241C7E96B3" modified="2017-01-18" version="1">MVATRLGHADPAITLRVYVHVIRSAEVAAADVFAKVMSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YTK2</accession>
    <name>A0A1H5YTK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NIPSNAP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26825">
        <property type="protein sequence ID" value="SEG26825"/>
        <property type="gene ID" value="SAMN04489712_104151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="1">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="99" mass="11861" checksum="A9E35336E9B253DE" modified="2017-01-18" version="1">MARTTQLRVYTVREGLLDEWADKWRELIVPLRLEFGFEIHGAWLDREKNQFVWVLSYAGPEGFAERNAQYWASPKREQMELDPKDYLLETEKREVDSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YYD7</accession>
    <name>A0A1H5YYD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29289">
        <property type="protein sequence ID" value="SEG29289"/>
        <property type="gene ID" value="SAMN04489712_104261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG29289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="88" mass="10126" checksum="1078BFC7687D5FD1" modified="2017-01-18" version="1">MTDSVPVTITLLGKPGCHLCDDAREVIVRVAADLGVAWEEEDITRSPELTRRYWEQIPVTLVNGVQHDFWRVDERRLRAAVEQARRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YYU3</accession>
    <name>A0A1H5YYU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-superfamily subfamily IB hydrolase, TIGR01490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29204">
        <property type="protein sequence ID" value="SEG29204"/>
        <property type="gene ID" value="SAMN04489712_104257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG29204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="31186" checksum="BE6CACB890EFB548" modified="2017-01-18" version="1">MRRFWRRTETDHVSAGEVAAAAAEPHALRPEPDPTAAAFFDVDNTMMRGASIYYFARGLAARKLFTMRDLAMFAWGQALFRVRGTENAEHIGTAKEAALAFVAGQKVEDLVRLSEEIYDEVMADRIWHGTRALALQHLDAGQQVWLVTATPVEVARVIAHRLGLTGALGTVAETKDGVYTGRLVGNLLHGPAKAEAVRALAQREGLDLARCSAYSDSVNDLPMLGTVGHPHAVNPDSALREHAKANRWPVHDFRTGRKVTMVALPAAAGAGALAGGVAAGIALRRHYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZF1</accession>
    <name>A0A1H5YZF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c-type biogenesis protein CcsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_104276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29643">
        <property type="protein sequence ID" value="SEG29643"/>
        <property type="gene ID" value="SAMN04489712_104276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="7">
        <location>
            <begin position="121"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG29643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="333" mass="35936" checksum="113CDB1253B0C34E" modified="2017-01-18" version="1">MADGDLANLSDQLMLGTVLLYVVAMVGYALDLGFGLRRRQTEQTEQAEQAAPAKVLVGSAGAEAVDAGTDAGDAADADADEGGRRRETDWGRFAVLINVLGWGAHLGMLVTRGWAAERWPWGNMYEFLSAIAFAAVTAYLVVLVRHKARFLGAFVMVAAVIALGIATIWLYTPVGPLVPALKSYWIAIHVSAAIVATGAFTVGGTATLLYLLQSRRQERGTEGGGALALLPGADTLDRLAYKITMFAFPIWTFAIIAGAIWADEAWGRYWGWDPKEVWSFVTWVIYAGYLHARATAGWRGRKAAIISLVAFAALLFNFFGVNYMFSGLHSYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZE57</accession>
    <name>A0A1H5ZE57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34350">
        <property type="protein sequence ID" value="SEG34350"/>
        <property type="gene ID" value="SAMN04489712_104495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="234" mass="26188" checksum="30D7E8F0987D80BE" modified="2017-01-18" version="1">MDTVEIQRVVAIEDDNWWYRERRAIIARQLRRLEGPPGRAADIGAAGGGNTRVLLEHGWEAIAIDASPAAVELARLRGIDAYHGDACYLPLSTGDFDFVMALDLLQHIPDDRTAAGELARVLRPGGSALISVPCDLSLWSAHDIALGHVRRYTRESLAEVVRDAGLHLDHMWSWNVLLRPIVKWRRHQSTPQDMERLHPIVNAGLRAVSMLERYLPVQSLPGVTLFARAHRPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZXT8</accession>
    <name>A0A1H5ZXT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41021">
        <property type="protein sequence ID" value="SEG41021"/>
        <property type="gene ID" value="SAMN04489712_10561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG41021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="26540" checksum="E31F575E760F541D" modified="2017-01-18" version="1">MTGDGLRGRVALVTGASSGLGRATAAALAEAGAQVIVHGRDAARLAEVAGAVGGVAVPGDLAVPAEVERVAAAALDVAARIDVLVCNAGAGWAGPFEAMPAADGDRLVAVNLAAPIGLTRLLLPQMRRRGGGRLVYVTSIAGRLGVAGEAVYAATKAGLDAFAESLRQELRGSGVTVGVLVPGVVDTPFFVRRGAPYTRGRPRPLPPDRVAGALVRGIAAGSPEIYVPGWLRLPVAVRGLAPAVYRTLAGRFGERVTPADPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A785</accession>
    <name>A0A1H6A785_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44599">
        <property type="protein sequence ID" value="SEG44599"/>
        <property type="gene ID" value="SAMN04489712_105260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="121" mass="13526" checksum="84B5946DC948AE69" modified="2017-01-18" version="1">MTAGQDDTCRIVDIDGTPVRVRGAADMDATDRAMLGEVVAAARRKHEQETPTDRAALTCPVPNCGHRKQARQYLCRGCWATLPRHARTALSRRDDKAMRRLSELLDQVRDGVPLHQVRVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AHX7</accession>
    <name>A0A1H6AHX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47992">
        <property type="protein sequence ID" value="SEG47992"/>
        <property type="gene ID" value="SAMN04489712_105451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG47992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="240" mass="26409" checksum="0EF2DF5EAF512952" modified="2017-01-18" version="1">MNTAPPPAFGDPPPPDLTQHAAVLRPPARQWPVHCGMIALDITGFARRADPHLQLHLRQALYRITHEACRSAGLDWDACHREDRGDGLLLIAPPAAGVHILLHPLVGHLLAGLRAHNKVAGRSARLRLRMAVHAGFVYADPYGVTGTAVNHLFRLLEAPAFKAAATGDLALIVSGYLYEEAAVHRLGLPGPDRLTPLTITSKETRTVAWTWQPTGPRPDRLARALQQDGRPPRRQRRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJN8</accession>
    <name>A0A1H6AJN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crotonobetaine/carnitine-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48287">
        <property type="protein sequence ID" value="SEG48287"/>
        <property type="gene ID" value="SAMN04489712_105467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="440"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG48287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="546" mass="60107" checksum="1FBA2EC70478C436" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZH4</accession>
    <name>A0A1H6AZH4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_106117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53792">
        <property type="protein sequence ID" value="SEG53792"/>
        <property type="gene ID" value="SAMN04489712_106117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG53792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="11938" checksum="C8BA2C1D4128607C" modified="2017-01-18" version="1">MTPADPPSGRSDRLADPGAQLERTALAWQRTALLIAINGALLARAATELGPAAVVSGGTVIVVAVVIWLAAARGYRRGRGRTASSVLTAHVRATRALTAVIAVIAALDLTAVLLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B407</accession>
    <name>A0A1H6B407_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt/nickel transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_106224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55340">
        <property type="protein sequence ID" value="SEG55340"/>
        <property type="gene ID" value="SAMN04489712_106224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PDGLE" evidence="6">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG55340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="118" mass="12203" checksum="84B4C356FB20BFBC" modified="2017-01-18" version="1">MTTGNRRFLLAFLLAFLLVALVVAGVVSFYASGDPDGLSKVAEDKGFAAQEEDHALKDSPLGDYGVKGVENERLSGGLAGVIGVGLTAAVGGGLFWAVRRRPRATPSGDVPAGSSERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5S6</accession>
    <name>A0A1H6B5S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56201">
        <property type="protein sequence ID" value="SEG56201"/>
        <property type="gene ID" value="SAMN04489712_106293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG56201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="26331" checksum="8E03C06479E92A95" modified="2017-01-18" version="1">MTEHPGFGVLLARLSAHRNLDVGALSPLVGAGEPELQAVMGGAAPDSSLLRRLAPVLGLRTADLFVMAGAVVPDDLAPLDAKAGLLVPPLVKRAVSLPSEHVHRLRQLVRSLPQQNRTQPVPPPPAWEQYQPGFGALLVRMLRNRSLAWTGSAMVLLCLTGRYLAGATIGAVGGGRKELTPDLLADFATVLGIPADDMAALTGIELPDVAPRQNPVAADVAELIWDVRRLTADQVEQVRTTAESLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BFT8</accession>
    <name>A0A1H6BFT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59599">
        <property type="protein sequence ID" value="SEG59599"/>
        <property type="gene ID" value="SAMN04489712_10779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024197">
        <property type="entry name" value="UCP030802"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030802">
        <property type="entry name" value="UCP030802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG59599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="284" mass="30496" checksum="73ECAB11124CEF85" modified="2017-01-18" version="1">MKTVVCTDLDRTLIYSAAALHLAGPDETLPRLLCVEHYQAKPLSYVTETAAGLLERLAEATTLVPTTTRTPEQYRRVRLLGKPPSYAICANGGHILVDGVDDADWAAQVRARATGAELAEVHEHLTRIGGAFVLKLRIASGLFSYAVVDRPTLPAGWVEDLSGWCAERGWRTSLQGRKIYCLPAGLTKAAAAAEVARRTGADRMLAAGDSLLDIELLEAADIALRPAHGELAETGWNAPNTAVTVTRGVAAGEEIAGRLLDRVLDPTKIPATGPWRRLPQPDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BG76</accession>
    <name>A0A1H6BG76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59768">
        <property type="protein sequence ID" value="SEG59768"/>
        <property type="gene ID" value="SAMN04489712_10789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG59768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="12685" checksum="B1E56CD8C33570B1" modified="2017-01-18" version="1">MTAPSLDGRRFRAVADVTGGEVGTGTTFEYHERDGEIWAAYSGGAIRRGHLVGTRDGDRLDFRYSQLNVEGQTANGHCVSVVRVLDDGRLRLEETWQWESQPGSGTSVVEEVVDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BGY4</accession>
    <name>A0A1H6BGY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ORF">SAMN04489712_107100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59950">
        <property type="protein sequence ID" value="SEG59950"/>
        <property type="gene ID" value="SAMN04489712_107100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG59950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="25624" checksum="EBB0CFC433C9F7D2" modified="2017-01-18" version="1">MTRRYAAHAGVSAELGPDGRTRLTRLRSDGPLALRETPDALYLVGAAAGPLGGDELTLDLEVGPGARLAVRSAASTLALPGAGESRLTVRAWVGAGGCLDFAPEPTVAAAGSRHRALAGIDLAEGAALRWREELILGRHGEQPGRHTGRLDVTVGGVPLLRHELCLDEEAAVRSGAVLGGATAVGSVLLAGPGLPVPRAHAGDGLAVLPLAGPGVLVTALAADSATLRRRLDEGEALARQAETGSAAGAGAVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BH16</accession>
    <name>A0A1H6BH16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59526">
        <property type="protein sequence ID" value="SEG59526"/>
        <property type="gene ID" value="SAMN04489712_10774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="195" mass="21400" checksum="2487EA178D32926B" modified="2017-01-18" version="1">MRLPGSAPSQEEATGAVVHYRTDQPVGLAVLTLLSVAAVVGGPYALARELGAPQFLVNPAAFVLVVLYISRFATRSVTRTAAGRLTVQGHRYGIDRRYRAELDVHQVTAIHRLTWARLSFGSVRIHGDGGMVKLRPTVRCVSKPKDWIRQNRVTGAGTDLQKLVYRMLLINPSISVKGIAAPLYLALDGRRYLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKS0</accession>
    <name>A0A1H6BKS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61309">
        <property type="protein sequence ID" value="SEG61309"/>
        <property type="gene ID" value="SAMN04489712_107202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG61309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="40747" checksum="5D6D8F514CAC2B64" modified="2017-01-18" version="1">MANRPGTPRLLRELNDRAALELLIDQGPLTRAQIGRHTGLSKVTASQLLARLEERGLVEVVGEQAGGRGPNAALYAVVPASAYVAGLEVGPHGVTAGIADITGRLIAQVTGDPNGADDPVKVVHNAVVKACRSARVALGRLNAFVIGTPGVVDPRSGDVQFVFDLPAWHEGVLAGLRTDLRRPVVLENDVNLAALAERAYGAARDAEDFALMWCDRGIGLSVMLGGRLHRGVSGGAGEIGYLPVPGVPLPDAVTESISWGTPALAGGLGSLVGADAVLALARSHGLTGATAVECVREAAADIARGGSFLDELAVRISYGVASVNIVLDPGLVVLSGQLGRAGGAPLAERIEQAVGRICPTRPRVAVTEVEGNPVLRGALHAALEQAREEVFSATAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BMF7</accession>
    <name>A0A1H6BMF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61386">
        <property type="protein sequence ID" value="SEG61386"/>
        <property type="gene ID" value="SAMN04489712_107209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG61386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="294" mass="31279" checksum="C7E66B51F360DB45" modified="2017-01-18" version="1">MTLDDLRVFVAVCEAGNLSAVARDLSCSQPAVSQHVKRLERETGLVLLERRPRGVVPTQAGRILYRAAAEGIAGLGTALRALDDLRRGTSGTVRISTGATTVRHFMSAGVAAFRARHPDVTLEFQTAGSSRRCLEAVQSHQADLAWVTIGRPVRGVEQRPSTSLPWALAVRVDDPLAHRGSLRPGELAGIRHIRLPEESTSGAHLAAHLAGHGIRLESTTSVADWDTALLLAELGLGHAILPSLPGWSHGPGSVVRLVPIPDLPPLTAGWAARRWDALSPLALEFADTVVASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYG1</accession>
    <name>A0A1H6BYG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65497">
        <property type="protein sequence ID" value="SEG65497"/>
        <property type="gene ID" value="SAMN04489712_108110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG65497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="27455" checksum="0A44EE939B02CE88" modified="2017-01-18" version="1">MDVREQAAAAPVPAEDLAEAGLRLEIDGPVATITLDRPDKRNAMTFAMWRTLARIGDALPGSVRVVVVRGAGKAFSAGIDLSMFSEGGGPTADPQEGDRFIAELQAGYTWLRRPEIVSIAAVHGYAIGAGFQLALACDLRVLADDAWYCMKEPALGLVPDLTGTKPLVDIVGVNRAIDICLTARRVAAPEAAALGLAERLVPAAGLDDAVADLVAALLQVDADAAVATQRLLREAPGNTLEQQCAAERREQLARLRALRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZV5</accession>
    <name>A0A1H6BZV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tricarballylate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66163">
        <property type="protein sequence ID" value="SEG66163"/>
        <property type="gene ID" value="SAMN04489712_108169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="103"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG66163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="475" mass="49413" checksum="E1383D9DD1B2ED6C" modified="2017-01-18" version="1">MPENESSVIVVGAGIAGLSAAVAAAEAGAAVTVVERAPRADSGGNTRHTEAFLRMKSIDEVADDLEERLLGDFMGHPDPGLLVESLRDPATWPAPLRSLSVVDPQVVATLVENAGPTLRWIEGHGVRFEHLATPFLTTSTTRLMPVGGGLALVEALTAAAEKLGVEFGYGTTARELLLDGGRVAGVNTSRGVLRGRVVLACGGYEGNAELMARYHGRGGRYTRPVARGGHYNKGEGLLMALKAGAATAGDFSLFHAEPVDPRSGVAEAAIFSFPYGILVNTRGLRFTDEAPGPVDAWYERIARRIHEQPDGIAYAIFDSGAADVPNLSAAVRTDQPPITADTLDGLAAELGIPAGALARTVAEFNAACPDGEFRPLELDGLATTGVRPAKSHWARPLADGPFSAYPIIAANVFTFGGLKTNDAAEVLDTDGDPIPGLYAAGELTGLYYTDYTGSTSVLRGAVFGRIAGLGAAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8N0</accession>
    <name>A0A1H6C8N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69339">
        <property type="protein sequence ID" value="SEG69339"/>
        <property type="gene ID" value="SAMN04489712_10974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG69339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="236" mass="25984" checksum="88A513FBE83923AF" modified="2017-01-18" version="1">MSGDAEPSAGRPALAGKQLSEQVAVHLREAIMIGELRAPAYVRTEHLAAELGISATPVREALMILHSEGAVRWEPRRGFRVLPLTERDVDDLFNVQSYIAGELAARAATALGEPEIEHLRRIQARLERAARDGAADLVDALNHEIHRTINRSSGSSRMTALLNLTVHYVPLRFFGKVEGWAEASAHDHSAIFDALHSRDPEAARTAMTDHIRHVGRLLIDHLRSRGVLEEPPAPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CER4</accession>
    <name>A0A1H6CER4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71267">
        <property type="protein sequence ID" value="SEG71267"/>
        <property type="gene ID" value="SAMN04489712_109255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG71267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="27584" checksum="F86E267E6AE71228" modified="2017-01-18" version="1">MPDAPRVPSVADMERTAPDTEASGGTAPSTKTSPGTAHGSKTSPGTALITGASRGLGRALAHALAPDGWNLIITARGAAELRAVAGELAGHTGTVTAVPGDVADPAHRAALADAVHGGLDLLVNNASTLGTVPLPRLADQPLDELEAAFRVNALAPLALIQALLPALRAHGGTILNISSDAAVEAYPTWGGYGATKAALEQLSNVLAAEEPDLRVYWVDPGEMRTPMLADAMPSDDLSEIPPPEVAAAALHRLIAGRPPSGRYRAAEIGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CFP5</accession>
    <name>A0A1H6CFP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71465">
        <property type="protein sequence ID" value="SEG71465"/>
        <property type="gene ID" value="SAMN04489712_109273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG71465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="57" mass="5782" checksum="6812F4265F125E01" modified="2017-01-18" version="1">MVTQAVPAGSTVEVHRDGELTRVDVTARVHAPALTALPPAVLRTRALAATEPGAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CL56</accession>
    <name>A0A1H6CL56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73385">
        <property type="protein sequence ID" value="SEG73385"/>
        <property type="gene ID" value="SAMN04489712_110104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="18539" checksum="E2DDA45C455BD836" modified="2017-01-18" version="1">MEEGTSKSLGNCCGTGDDQDAFQWDARADCEVRQILDRIADKWSLLVIALLDRRSLRFTELRRKIDGISQRMLTRTLRHLERDGLISRTVHPTVPPRVDYALTPLGVTLHATVQTLVTWTEEHQSEIAVARTAYDARTAAEQEAARREAAERDAVARDVLTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNI5</accession>
    <name>A0A1H6CNI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monosaccharide ABC transporter ATP-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_110245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74584">
        <property type="protein sequence ID" value="SEG74584"/>
        <property type="gene ID" value="SAMN04489712_110245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="248"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG74584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="495" mass="52483" checksum="8EAD4534E2D64DE3" modified="2017-01-18" version="1">MSEPQTPLLEMRGIVKRFPGTLACDGASLSVRAGEVHCLLGENGAGKSTLMKILAGSYRPDEGEITLAGRPLRCTSPQDGLAAGISVIYQELDLAPDLTVAQNLFLGRAPARGPFVRRRARSAAAAEAIRRVGGTFSPEDRVRDLPIAAQQLTAIAKALTMDARVIVMDEPSATLGERDLEVVFSVIRDLAAEGRAIIYISHRLDEVSHIGDRATVLRDGRDVGVFDLATTSHDELVGAMIGQARELVRRADRPEPTGAPRLSIEHVTVGDILDVSGIDVRPGEIVGLAGLAGAGRTTLLAALFGAVRGEVRARLDGRPLPVAGPRTAVRNGLALVPESRKEQGLFLGLGVARNAAIAAHGLVAPRTRGRKKTAPVLTGLGVKHASPEQPVGQLSGGNQQKVVLAKWITRGMRVLLLDEPTRGLDIGAKADLYRQVRRLADDGVAVLLASSELAELTAHADTVWVLHEGRNVARFDPRTTPEADIAHTVITGAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CPJ4</accession>
    <name>A0A1H6CPJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74346">
        <property type="protein sequence ID" value="SEG74346"/>
        <property type="gene ID" value="SAMN04489712_110216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="31125" checksum="6AFEEE2B03D1E480" modified="2017-01-18" version="1">MPIVRDPLDPKISMWHFLSYYLRFMREKEGLSLTQWGRIIGAAKSTVSNIEAGRHRLQEDHAKIIDRKFGTGRLIELLLWFARAAHDPDWFRQFTQYEEQANALKMYHGDVIPFPLQTDEYTWAYVQASNHKDQEGEYAARLQRKRNILDRKNSPFIWAMLHESALASLVGGAEVMRAQLRYLREVADLPHVIVRVIPFAAGAHLGADGPFQIISLETRDIAYAGAQNGGRLVEEPSEVREFGFTFDRIGAKAASEDDSRKLIDQWLERCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZW1</accession>
    <name>A0A1H6CZW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RHS repeat-associated core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78570">
        <property type="protein sequence ID" value="SEG78570"/>
        <property type="gene ID" value="SAMN04489712_11293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028948">
        <property type="entry name" value="Ntox28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15605">
        <property type="entry name" value="Ntox28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="3">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ntox28" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG78570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1246" mass="137323" checksum="43D34519370A9671" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1T1</accession>
    <name>A0A1H6D1T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, contains ParB-like and HNH nuclease domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78948">
        <property type="protein sequence ID" value="SEG78948"/>
        <property type="gene ID" value="SAMN04489712_112145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="16"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="449"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG78948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="619" mass="72533" checksum="E05C1B0287BDE1DE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4L1</accession>
    <name>A0A1H6D4L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-lactate dehydrogenase complex protein LldF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80272">
        <property type="protein sequence ID" value="SEG80272"/>
        <property type="gene ID" value="SAMN04489712_11353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00273">
        <property type="entry name" value="TIGR00273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="457"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG80272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="488" mass="52896" checksum="4DC7B12FBE9D7E8D" modified="2017-01-18" version="1">MSEHATRDRGRASMPTYLGMPPFPEAAGKAVADTRLRGNLAHATGTIRDRRLSAVAELDDWDALREAGKQIKDHTLEHLDHYLLLLEEKITAAGGTVHWARDAAEANRIVADLVRATGHTEVVKVKSMATQEIGLNEALAEEGITAYETDLAELIVQLGDDRPSHILVPAIHRNRAEIRDIFRSRMPDAPADLSDSPAELAEAARRHLRAKFLSAKVAVSGVNFAVAETGTLVVLESEGNGRMCLTLPETLISVMGIEKVLPTWQDLEVFLQLLPRSSTAERMNPYTSTWTGVTPGDGPRDFHLVLLDNGRTDTLADQVGRQALRCIRCSACLNVCPVYARAGGHAYGSPYPGPIGAILSPQIRGIGSPVDASLPYASSLCGACFEACPVAIDIPEVLVHLRAEAVEEGPKHPLVGTAMAAAGWTLRSPRRLALAQRLASASRRLVGRRGQIRRLPGPLRAWTDSRDAPAPPPESFRAWWKRTNGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6J7</accession>
    <name>A0A1H6D6J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_113137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80714">
        <property type="protein sequence ID" value="SEG80714"/>
        <property type="gene ID" value="SAMN04489712_113137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="23550" checksum="B466CA24DAC03C59" modified="2017-01-18" version="1">MLERLREVEGTVLDRPAYHADSAREKARLTGVIWKLERAQHFSEPHDPAWQALMDGDWDRALRIFEEERPGVRENARSYARRGTPFRRLRVVERPVSRYLRWEMHYFRILAEEGFELRVIDAARLAELEREQPVPEVVVLGEKVLYQVRYDEQWAPCGARRITDPQAVRATAAQIAALWEQGEPLIDFFHREIAPTTVSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAQ7</accession>
    <name>A0A1H6DAQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein PhnB, glyoxalase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81933">
        <property type="protein sequence ID" value="SEG81933"/>
        <property type="gene ID" value="SAMN04489712_114175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="15049" checksum="A7DA0CEEE7D9E6E4" modified="2017-01-18" version="1">MDITIHHTFLPHNDPDASLAFYRDALGFEVRNDVGYDGMRWITVGPADHPGTSIVLHPPAVDPGITDDERRTIAEMMAKGTYASIILATKDLDGVFERLQAGDAEVVQEPAEQPYGVRDCAFRDPAGNMVRIQELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DC88</accession>
    <name>A0A1H6DC88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82295">
        <property type="protein sequence ID" value="SEG82295"/>
        <property type="gene ID" value="SAMN04489712_1155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="112" mass="11947" checksum="999AAC3339EFBB18" modified="2017-01-18" version="1">MRAESADRVPLTRELWGAVLAGLHSDHPAVRDRVYAAVLAIGPREWDEDLETPGALVRRLADIGTPGPRPATAQAAWISGGTAPSARDTSASPSEDCDGLTAVHRDDGRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCZ8</accession>
    <name>A0A1H6DCZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82663">
        <property type="protein sequence ID" value="SEG82663"/>
        <property type="gene ID" value="SAMN04489712_11559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295771" evidence="2">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9024" checksum="689F02C5B5576A37" modified="2017-01-18" version="1">MLKRLATAGVLAATVGGMLVSAAPAVADNGPHAPGKARKHSKTSQNGCGTYGEKATMMRSLEILEIHYIVIGNSPQVGFTIADCKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE55</accession>
    <name>A0A1H6DE55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_115120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82993">
        <property type="protein sequence ID" value="SEG82993"/>
        <property type="gene ID" value="SAMN04489712_115120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="101" mass="10812" checksum="F8A1CD1E43E7D83B" modified="2017-01-18" version="1">MSIASPEIAAPQPPRLPLGVQADGTLTRKAVPIAFVMGTLAVFAVLPLGVLAIILNDRGLERVRTSPQTARRMINWSWGILAVVDVLEIIALTGFLVDRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE69</accession>
    <name>A0A1H6DE69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroimidazol reductase NimA, pyridoxamine 5'-phosphate oxidase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83678">
        <property type="protein sequence ID" value="SEG83678"/>
        <property type="gene ID" value="SAMN04489712_11647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="21377" checksum="326A65E627B2CF3A" modified="2017-01-18" version="1">MSGPAAARRTIAMSREEIPMGPMGKEPFDVELDPRFSVPDASAAPWSEARRLLAEAELYWLTTLRPDGSPHTTPLVAVWHDDRLYFCSTPGERKVRNLELDPRCILMTGCNHLHRGLDIVVEAEATRVTRTDELARVAAAYRAKYPEQWHFTVGDDVLVGTAGKAWAYSMAPKVAFGFAKGEFAQTRWRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE87</accession>
    <name>A0A1H6DE87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83747">
        <property type="protein sequence ID" value="SEG83747"/>
        <property type="gene ID" value="SAMN04489712_11660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="6825" checksum="C72A1D9BF18E7593" modified="2017-01-18" version="1">MKATVDPDRCQGHARCWEIAPEVFGLDEEGHGTVLVGEVPAEHREAARRAADNCPERAITVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEA1</accession>
    <name>A0A1H6DEA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamyltranspeptidase / glutathione hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83580">
        <property type="protein sequence ID" value="SEG83580"/>
        <property type="gene ID" value="SAMN04489712_11629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="598" mass="64043" checksum="4C54314F12AB3A46" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFJ7</accession>
    <name>A0A1H6DFJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83852">
        <property type="protein sequence ID" value="SEG83852"/>
        <property type="gene ID" value="SAMN04489712_11682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="29541" checksum="240D0A72C1D5A255" modified="2017-01-18" version="1">MSQDFLGLDGRVVIVSGAGGGGIGTAVTRMAARAGATVIAVSRSQDNLDEHVRPLAAEGLPVVPVAADAATDDGIATVMKQVGRTDGDLHGLVNVAGGAAPATWMPSTRVTRKDWRALFAQNLETMFFMSQAVAAQLRSQARPGSIVSISSISGMNTAPFHIAYGTAKAALVAATRTMAVELALDGIRVNAVAPGVTVTPASGTYVEEDFERDCRAIAMGRRGRPEEQAGAILFLLSDLSTYITGQTILVDGGLNLKWSHLAADNTTLFLKDESFRAAITRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFM8</accession>
    <name>A0A1H6DFM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">o-succinylbenzoate synthase</fullName>
            <ecNumber evidence="2">4.2.1.113</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_116139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84079">
        <property type="protein sequence ID" value="SEG84079"/>
        <property type="gene ID" value="SAMN04489712_116139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010197">
        <property type="entry name" value="OSB_synthase_MenC_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48073:SF5">
        <property type="entry name" value="PTHR48073:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="3">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG84079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="36907" checksum="1AF565E2804BBC6F" modified="2017-01-18" version="1">MPRVQGCQAFRVTMPRGRRPQSILVRLTGEDGTVGWGEVAFPEPPDSTWADIEERLAPALLGLDWERPEDVSATSEFGTRRAAAAVDIACWDLWCRIRGLPLAHALGGTRTSIVTGVRIDTEPFLLETLVTRANQAVGGGHTRVTLRVRPGWDIEPVRAVRAAYPALAVVADAGGSYTESAEHLDALQALDAYGLLALQRPFPTGDLAAHARLQQRLTTALCPEIGDLDMLDAAIEQQAGRALGLDVSRLGGLTAARGAHDRAYSAGWDVWCVGSGSFGIGQAAAVAVAALPGCTLPSDVTDPAGGPAFVSPPVRSSGGVVGVPLTQPGLGHEVDEDRIARLATDTLRIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJZ0</accession>
    <name>A0A1H6DJZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine dioxygenase, alpha-ketoglutarate-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_117149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85153">
        <property type="protein sequence ID" value="SEG85153"/>
        <property type="gene ID" value="SAMN04489712_117149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG85153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="30366" checksum="027E9612C9D6A956" modified="2017-01-18" version="1">MMETVALSPHLGAEVKGVRPEDLLDDAVVARCLEALTWRGVLLIRGLHLDDEAQLAFSRKLGEVIAVSGQEIFTVSLDPAKSRNAEYLKGTFHWHIDGTTDDVPPKATMLTAKHVAMTGGGTEFANTYAAYESLPGKERERYEGLRVVHSFEAAQRLVKPDPTERELKGWRSVPTHESSLVWRRRDGRCSLAIGATADHIVGMDPRESRALLDELQDWATQERFRYAHDWAVGDVVIWDNTGMLHRALPYEQTSERTLHRTTVRGDEPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DK29</accession>
    <name>A0A1H6DK29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85544">
        <property type="protein sequence ID" value="SEG85544"/>
        <property type="gene ID" value="SAMN04489712_11829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core3" evidence="1">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="15424" checksum="1C0A72D68C1161AE" modified="2017-01-18" version="1">MTMPVTLEETVRVPLRRRTAARPAVLAAALLERLPPRRLRQVLRAAARGSRPATRAQALAARQAVVSVSVRCAGQGCLRRSIAVALLCRLGGAWPDWCTGVRTEPFRAHAWIEVDGQAVGEHEDMRLYHKTMAVPARRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DK83</accession>
    <name>A0A1H6DK83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_117133</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85085">
        <property type="protein sequence ID" value="SEG85085"/>
        <property type="gene ID" value="SAMN04489712_117133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="72"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="199"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="308"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG85085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="504" mass="55439" checksum="343433339268521B" modified="2017-01-18" version="1">MRAVLGDARPERAGRDDTAAEMLRRRARGRTGRRRPRPGAGADIAPGRAPSRLAPPAEERNPCMWDFSTDPEFQARLDWVAGFVREEIEPLDVLFSGTAEPYDRDGEVFREVVRPLQAQVKEQGLWAAHLPPHLGGMGMGQVRLALLNEILGRSQWAPMVFGTQAPDSGNAEILAHYGNEEQRRRFLEPLLDGRIVSTFAMTEPQGGADPGGFTCRAVRDGDEWVINGEKWFASNYPHAAFVIAMIITDPDVPVHQGSSMFIIPKGTPGMAQVRGTGLGEEPIGEGAHAYLRFTDCRVPAENLLGEPGTGFAIAQTRLGGGRLHHAMRSVGQCRRAMEMMTERIASRSTRGGPLSKQQAVRQSLADTWIQIEQFRLQVLHAAWQVDRSRETGDPAHARLARLHISAVKAATPKTLVDVVYRAMHLHGSLGVSNELPLIRMWQSGPVLGVADGPTEAHKDVVARLLLQDAVPAEDRLFGSEHIPTRQAAAREKFAGRLKRLEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLP3</accession>
    <name>A0A1H6DLP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, CarD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85763">
        <property type="protein sequence ID" value="SEG85763"/>
        <property type="gene ID" value="SAMN04489712_11875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="160" mass="17933" checksum="8179AD04581F8DBE" modified="2017-01-18" version="1">MTFTVGDTVVYPHHGAARIEAIETRTIKGEDKTYLVLKVDKGDLTVRVPVENVEDVGVRDVVGQEGLEKVFEVLRAPYTEEPTNWSRRYKANLEKLASGDVNKVAEVVRDLWRRDKERGLSAGEKRMLAKARQILVSELALAEKTNEDKAEALLDEVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLP7</accession>
    <name>A0A1H6DLP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86230">
        <property type="protein sequence ID" value="SEG86230"/>
        <property type="gene ID" value="SAMN04489712_11928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="358" mass="38133" checksum="84D668CC343379CB" modified="2017-01-18" version="1">MPLLDTTLMAALCRPVTGGDKDLIPVAAIVGTYGSSAGRPSEPYYRVGVDLRLLRFFVAIIDHGGVTRAAEALYVAQPSVSQALRTLEQRLGVSLFERVGRGLRLTDAGRELEVRARSVLAEVEEARARVDRVARLDAGRLTVAAASTLAIHPLGPWVKHLLGAHPGLQVHVSEPGSVPAVLAEITDGAAEIGLVELPVHKASLQTVELAQEELVIAAGPGLAAGLPDPLPRALVPDLPSGALARVPGGRTASERTMAEVLGEPRIRSAHRQLLWELVGQDVLVTFVSRAVAERLLPDVELRSLDPPVFRRVGLAHRPERLTPAAQALLEIALSPRVRRPRRGAPPATSSGDPMPDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMN1</accession>
    <name>A0A1H6DMN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86464">
        <property type="protein sequence ID" value="SEG86464"/>
        <property type="gene ID" value="SAMN04489712_11990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="809"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="880" mass="92680" checksum="FDA0656595E41C49" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPC4</accession>
    <name>A0A1H6DPC4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">trmD</name>
        <name evidence="18" type="ORF">SAMN04489712_12056</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 15"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87034">
        <property type="protein sequence ID" value="SEG87034"/>
        <property type="gene ID" value="SAMN04489712_12056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="17">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_m1G_MT" evidence="17">
        <location>
            <begin position="129"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="15">
        <location>
            <begin position="184"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="283"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SEG87034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="34152" checksum="5DEBF7A9B21FDCDB" modified="2017-01-18" version="1">MRLDIISIFPEYFAPLQVSLLGKARLRGLLDVHVHDLRQWTHDRHRTVDDTPYGGGPGMVMKPDPWGEALDTIAPPPSVPATGARSIPAGQATDAQTVDVQTVDVQAIAHEQAAGAEHGATEGRRPPVPRLIVPTPSGRPFTQAMAVELAAEPWLVFACGRYEGIDSRVVEEARTRMRVDEVSIGDYVLAGGEAAVLVIVEAVGRLVPGVLGNAESVADDSFAPGRMQTLLEGPVYTKPPVWRGRAVPDVLLSGHHGAIARWRRDQALRRTVANRPELAAELDPADLDERDRQVLAEAGLPPGGEAVAGAGLPPGGKAVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPV2</accession>
    <name>A0A1H6DPV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86813">
        <property type="protein sequence ID" value="SEG86813"/>
        <property type="gene ID" value="SAMN04489712_1205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296187" evidence="1">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="16457" checksum="52CD8BAC50C0B9BD" modified="2017-01-18" version="1">MRRMIIMVLVLSGSFGLSMWTGVGPADDWVHTCQVRQQYLDRLEAMEVEVDRLRVQGRSEQEIARIMVPRRNQAKALVRTKMKAKQVAKMEERNRARYGDPLGPTIDWMYTQYGGNWHDIVEASTDSNELYNLSCLPWFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DR71</accession>
    <name>A0A1H6DR71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87193">
        <property type="protein sequence ID" value="SEG87193"/>
        <property type="gene ID" value="SAMN04489712_12085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG87193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="477" mass="50896" checksum="8243A4CA945E6112" modified="2017-01-18" version="1">MPKDWSGSGLDLHLELDPAAGRRAGLERALRDAIRTGRLGPGTVLPSTRALARELGMARGTVSAAYDQLVAEGYLISRPGSGTSVAEVPDAAPGASAAETGTDPPRYDLRPGRPDLTTFPAAAWLRATRRVLAAMPAGAHALGDPRGRVELRTALAGYLGRARGVLAAPDRIVITNGYAQALNLLAQVLIESGVTAIAMEEPGHPYYRAIVQRTGLNVLPLPVDHLGARTDLLTGEGFGQAGAVVVTPAHQYPTGVILHPRRRHELTVWARTTGGLIVEDDYDGEFRYDRRPVGAVQGMAPEHVVHVGTASKVLAPAVRLAWTVLPGRLVERVAEAKLYADAQTESLGQLILADLIAGHGYDRHVRAGRLRYRRRRDLLVSRLRQRAPHVRVDGVAAGLHALVGLPPAGPGEQDVLERAAAHRLALQPLADHWLRPGDHPQGFVVGYSTPPEADYPAALDALCAALGGARFTHAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTB7</accession>
    <name>A0A1H6DTB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88508">
        <property type="protein sequence ID" value="SEG88508"/>
        <property type="gene ID" value="SAMN04489712_12218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG88508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="281" mass="30218" checksum="62726367C53EC68E" modified="2017-01-18" version="1">MNAVSTSPVPAPPARLEAVGVTVRFGGLVALNKVDLRIPPGSMVGLVGPNGAGKSTLFAVLSGLLRPNEGRVLMGGGDVTRATPQARARRGLSRTFQRPELFSGLTVREHLVLGDRVRHSGDRIWRDLLTGGGFRRPSKEEDERVDRLLEALHLGGLQHREAAGLSLGAGRLVEVARALAVEPEVLLLDEPSSGLDMRETEELAATLRRVVEERGLSLLLVEHDVDLVLGMCDTVNVLDFGAMIRSGTPEEIRSDPAVRAAYLGEEPAPRDAEAKRDEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU79</accession>
    <name>A0A1H6DU79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">NADH:ubiquinone oxidoreductase, NADH-binding subunit (Chain F)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SAMN04489712_12284</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88810">
        <property type="protein sequence ID" value="SEG88810"/>
        <property type="gene ID" value="SAMN04489712_12284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_51K" evidence="12">
        <location>
            <begin position="40"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="13">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="NADH_4Fe-4S" evidence="14">
        <location>
            <begin position="304"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEG88810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="386" mass="39704" checksum="32DA759EB02C3253" modified="2017-01-18" version="1">MVTTATQHRLLTPGPLDLAAELERGAYSPPACDDVIAELEAAGLRGRGGAGFPASVKWRTVADASGPRVVVANGEEGEPSSRKDRWLLLNRPHLVLDGLLLAARTIGADRAVVYLSHEETVTAMREAIAELPVPGLVPEVHVVEPTYVAGEETAACRSISGGPALPTARPPRVCDSGVDGRPTLVSNVETLAHAAWISRNGAAAYRESGTAGSPGTTLVTLTGACAAPGVYEVPFGLTVAELFEVAGGFTGAPAGFVMGGWFGGLLGPAHASTVCTYEAVRAAGSGFGCGAITALAPGTDPLTVAAEITAWYAAESAQQCGACLKGTAAIRDAFAALRDGTASDTDRHNLERWGRTLPGRGACAFLDGAAGWARTVHDEFPDHFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUY8</accession>
    <name>A0A1H6DUY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted metal-dependent hydrolase, TIM-barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88526">
        <property type="protein sequence ID" value="SEG88526"/>
        <property type="gene ID" value="SAMN04489712_12223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="84"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG88526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="381" mass="42985" checksum="5A9B5593E0211427" modified="2017-01-18" version="1">MPLQPWMKMLSTDDHLIEPPKLWSDRLPAKYREAGPTIVEQPRPSGGPPAEVWKYEDRLYPTIGLNAVAGKKPEEFGIDPTRYDEMIPGCYDPRARLADMDIDGVWGALCFPSFPRFAGTLFLEGEDPELAHLCVKAWNDYILDEWCATAPDRLIPLVILPLWDVQACVTEIHRTAAKGAKAIAFPENPVPLGLPSFHTDHWDPVFSAAEETGMPLTMHFGTSGQAPITAPEAPMAVMIALFGCNSMYATADLLFSPVFHKHPELKVGLSEGGIGWVPYLLERIDTTWERHRFYQNVNQDVRPSELFRRHIHGCFIDDSFGIEARHAIGVDNITWECDYPHSDSYWPKSRAVAAERLADVPDEEVHKIVELNVRRLYNFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWY6</accession>
    <name>A0A1H6DWY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89847">
        <property type="protein sequence ID" value="SEG89847"/>
        <property type="gene ID" value="SAMN04489712_12488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="130" mass="14120" checksum="DCCB77619419C24B" modified="2017-01-18" version="1">MARWSRLFDGKPESVGLARKFARLVLVDHVLADTVELVVSELATNALEHTSSGDLDGLFVVQLEVFPDRVEVAVIDMGADSRPVLVGDDPANVTALSGRGLHIVRALSKEWGCERVRVGLRVWADIACEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZJ8</accession>
    <name>A0A1H6DZJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, FadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90529">
        <property type="protein sequence ID" value="SEG90529"/>
        <property type="gene ID" value="SAMN04489712_12664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG90529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="244" mass="27056" checksum="8B8FF3146D7D0EE6" modified="2017-01-18" version="1">MPAFRQRAPKASERLARHLATSIIEGEFEEGARLPHEGAMLAQLQVGRATLREALRLLEVWGLIVIRTGPGGGPTVRRPQPAEFAEQLALMLQFQQFTLEDVSDARLALEPMMARLAAERIKPEQIADLRDSIEIMADSFEDPQEFWKQNARFHSGVAEAAESHIISMFVNALKVIGDGASSGVPYTRKEFEEIVRAHTKIVDVLELGDANAAAEAMHRHLDAGRRFVAGKYPAALTAKIQWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZP1</accession>
    <name>A0A1H6DZP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
            <ecNumber evidence="3 8">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_12745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90810">
        <property type="protein sequence ID" value="SEG90810"/>
        <property type="gene ID" value="SAMN04489712_12745"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="103"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="247"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="311"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="381"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG90810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="586" mass="64057" checksum="FECC5545AAD4F805" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0H4</accession>
    <name>A0A1H6E0H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91072">
        <property type="protein sequence ID" value="SEG91072"/>
        <property type="gene ID" value="SAMN04489712_12828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="11382" checksum="BC8989DB92722BEE" modified="2017-01-18" version="1">MTPRVIVLRPRRLTRPPVRPRPVPARPRPVPIRPFPSRRVGSSVLVGPVVEWDGVRGLHIATCDRCADTMTAVSAGRAYRWVEDHECDPELAALLANLTGGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1F4</accession>
    <name>A0A1H6E1F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE superfamily endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91392">
        <property type="protein sequence ID" value="SEG91392"/>
        <property type="gene ID" value="SAMN04489712_1293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="101" mass="11727" checksum="37F5E172634DC7C8" modified="2017-01-18" version="1">MVLVWDNLNVHRDARMRAFIDTCDWLTVFYLPTYSPDLNPVEGVWSLLRRSSQANTTFTDPDHLMRTLRRGLRKIQHRSHLLDACLAITGLTQTTTPFKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1X3</accession>
    <name>A0A1H6E1X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_13011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91658">
        <property type="protein sequence ID" value="SEG91658"/>
        <property type="gene ID" value="SAMN04489712_13011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG91658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="227" mass="25653" checksum="FAD8A31A17FDEF9E" modified="2017-01-18" version="1">MPEPAAGTGGASGGRTRVDRRRETTPRRLREAARVVFERDGFHNARLSDISTEAQVGSGTLYNYYRSKHDLLYELMKGISAELTGIAADHISAQQDPVHRVREVNRVYIKAFRRNARVLQAVYQARDEDERLKAQWDEVADHFQSRVTRAIADWQKAGMAYSDLDPRHTAHALTLMVERVVMAWSYEGVEYDAEVLIDTLDKIWIRSLGLTSPAKFHAGTTARPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E708</accession>
    <name>A0A1H6E708_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92714">
        <property type="protein sequence ID" value="SEG92714"/>
        <property type="gene ID" value="SAMN04489712_1359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="46" mass="5356" checksum="1D23BCD11784DF0D" modified="2017-01-18" version="1">MTPFCEVADVRVSRKPWLGCRFDLRGEDGRMAAQWTRNLVLLGFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7G2</accession>
    <name>A0A1H6E7G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_13743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93201">
        <property type="protein sequence ID" value="SEG93201"/>
        <property type="gene ID" value="SAMN04489712_13743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="52"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG93201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="313" mass="32680" checksum="BB6ED0EDC65187E5" modified="2017-01-18" version="1">MSNPTPNTPVPDSPSGSPMPASPRSGPRSGAPRLAVRKTYKLFIAGAFPRSESGRSYVVNDAKGAFLAYAAHASRKDARDAVTAARKAFAGWAGRAAYNRGQILYRIAEMLEGRRAQFIDELRAAGLAKTAAAGEVEAAIDRWVWYAGWADKLTTVAGSANPISGPFFNVSTPEPTGVVAVIAPDSPLLGLVSVLAPVIVTGNTCVVIASEPAPLPAITLAEVLATSDLPGGVVNILTGHREELAPILASHMDVNALDLAGTPTDQAGPLQEAAAGNLKRVLPPTGDEWTTDPATTRMTAFLETKTVWHPIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8Z0</accession>
    <name>A0A1H6E8Z0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94278">
        <property type="protein sequence ID" value="SEG94278"/>
        <property type="gene ID" value="SAMN04489712_1459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="71" mass="7777" checksum="3453B9839C2FD516" modified="2017-01-18" version="1">MTAQAVIKNGELLLPHPVGCGAELITPDDPRYDDLLAHAVRDEDLNGTPEQNAALAARWAAKWAREDRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB11</accession>
    <name>A0A1H6EB11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94116">
        <property type="protein sequence ID" value="SEG94116"/>
        <property type="gene ID" value="SAMN04489712_14314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="24509" checksum="4B0614E2B5B93690" modified="2017-01-18" version="1">MTSSPRSYEKELDGIERALESALEAVRGVPREGLTAAQWLEAAAELGRLQADAREASGRVRQALLGSARTALLAYLRAHAGQPVEADALEGVAAIQAWTRRIRELRIPFGWQVESGTWSADMQKDQYRLVADQLGEEVSRDEEVIKAIKGKTSKERILEYLLHLSPWPASPQQLERVAGAPTWRQDIRELIEEGWLIRSHEEDQDLAPGFYRLAKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB88</accession>
    <name>A0A1H6EB88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose 1,4-beta-cellobiosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000058">
        <property type="protein sequence ID" value="SEG95002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95002">
        <property type="protein sequence ID" value="SEG95002"/>
        <property type="gene ID" value="SAMN04489712_1583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296773" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG95002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="76" mass="7567" checksum="9715C7F50EF97312" modified="2017-01-18" version="1" fragment="single">MRSVPPPGTRGAPPGRRRGLAAGAAALLMASGLVTVAGTHQASAAVACKVVYKKNDWGTGFTTSIDITNTGDALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBW0</accession>
    <name>A0A1H6EBW0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94265">
        <property type="protein sequence ID" value="SEG94265"/>
        <property type="gene ID" value="SAMN04489712_1452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="29706" checksum="AAD4DB57B1CF9ECF" modified="2017-01-18" version="1">MVFLDALVVKVRDNHTVANKPAYLAVGIDADGDKHVLGIWLARTPQQTTTAAEGAKFWASVMSDLRNRGVVDILIACCDGLTGFEEAITTAFPHTTVQTCVVHLIRNALRLVPRKHHSAMAADLKKIYTAPTAEAAFDALAAFADTDLGRRHPQAVKVWENAWDRFTPFLAFTPPVRRLLYTTNSIESLNYQLRKVTKARGHFPSDDAVVKLLWLAILNIEDKRARERAAGTGKRSGYPGRLIEGQHTRGWREALNELTIAYPGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECR8</accession>
    <name>A0A1H6ECR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NeuB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000064">
        <property type="protein sequence ID" value="SEG95073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95073">
        <property type="protein sequence ID" value="SEG95073"/>
        <property type="gene ID" value="SAMN04489712_1642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NeuB" evidence="1">
        <location>
            <begin position="44"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG95073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="20960" checksum="A8429904AFD5A866" modified="2017-01-18" version="1" fragment="single">MSGAVGSSGSVWIGDREVGPGRPVYVIGEIGINHNGDVDIARRLINIAADAGCQAVKFQKRTPEICVPPEQQNKMRETPWGEMTYLEYKHRVEFGVEEYRQIAKYAADRGIDWFASPWDVPSVEFLENFDVVTHKVASASITDKELLRALAATGKPIILSTGMSTLEEIDEAVEILGAGKLVILHATSTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S128</accession>
    <name>A0A1H5S128_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44323">
        <property type="protein sequence ID" value="SEF44323"/>
        <property type="gene ID" value="SAMN04489712_10138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF44323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="33927" checksum="105C649EFC5988E0" modified="2017-01-18" version="1">MSSTVEIYLRGGRDAAAVVQQVATALDVRGYFGSGEGYVLTLSSEPWTTGEGVASLDLGPTDEDLVGALGETAYSPYDFRLSIELRGAPGLARAELRERLGRQVFDRLTALRWPMALGDAMSVFADFLPGRGVREFPPDTDWEEAGHDIWFEPRLHGTEPPASRQPPEPLIRGAATVFETNGLVQFLACDAAGAKAPVASIRSEAGATLLGRTLAEVLRYSAKEIRTGQADPWSWLTGIAKSSPDEYARSAVSLAIRLENEQVTAVPHRPHPGDPAGHVVQGPAIEALTVHRPGPWDDTAMGELVLGLLAAARGSVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S178</accession>
    <name>A0A1H5S178_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="11" type="ORF">SAMN04489712_10139</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44356">
        <property type="protein sequence ID" value="SEF44356"/>
        <property type="gene ID" value="SAMN04489712_10139"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="552"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="326"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF44356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="581" mass="62504" checksum="4684FCBDE7C20428" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S1H7</accession>
    <name>A0A1H5S1H7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10143</name>
    </gene>
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        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="104"/>
            <end position="363"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEF44473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="453" mass="50630" checksum="39C9A684D7317544" modified="2017-01-18" version="1">MDRQQEFVLRTLEERDIRFIRLWFTDVLGFLKSVAVAPAELEGAFAEGIGFDGSAIQGFARVYEADMIAKPDPATFQVLPWRAETPGTGRMFCDILMPDGTPSFADPRYVLKRALGKAADLGFTFYTHPEIEFFLMRNVPEDGSEPEPVDAGGYFDHTPHSAAHDFRRNAIMMLESMGISVEYSHHEGAPGQQEIDLRYADALTTADNIMTFRLVMKEVALEQGVWASFMPKPFTDHPGSGMHTHMSLFEGDRNAFYEPGAEFQLSKVARAFIAGLLRHSAEITAVTNQFVNSYKRLWGGVGASAGAGGEAPSYICWGHNNRSALVRVPMYKPQKGHATRIEFRSLDTAANPYLAFAAILGAGLKGIEEGYELPPGAEDDVWALTPAERRAMGIEPLPQSLDEAIHAMERSELMADVLGEHVFDFFLRNKRAEWEDYRRQVTAYERKRYIAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S2P3</accession>
    <name>A0A1H5S2P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein E (SpoIIE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10148</name>
    </gene>
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        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44624">
        <property type="protein sequence ID" value="SEF44624"/>
        <property type="gene ID" value="SAMN04489712_10148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF44624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="369" mass="39711" checksum="A0992BC629986720" modified="2017-01-18" version="1">MHTPDDLEESRAGGLGNGVLLLWLVGLPVVIMVLTLLSPAEARLALLLIFLPPYISGRGTVRQTAATAVWAGLLVVISVIADPLSNPVTGATVCLLSLALGAWSVVSCRRRIAGEERILRLRSAAATLQRQILRPLPLRTDQLVVDGMYEPAEEDSMVGGDVYEVIASPYGSRVLIADVQGKGLRAIGMALTVLGAFREAAYWQPDLLDVVDALESAVVRQNAFAKEIGERERFVTALVLGFDDGPRACAVNCGHVPPYILDQRTGTVLRHEAGVPLGLGALVPESRTVEWFDFPAGATLLLCTDGITEARDSSGAFYPLADRLGACHGTSPSEVVSFLRTELRRYTRERFRDDIAVLTLRRAHAAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S3J4</accession>
    <name>A0A1H5S3J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage shock protein A (PspA) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45172">
        <property type="protein sequence ID" value="SEF45172"/>
        <property type="gene ID" value="SAMN04489712_10166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="44"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF45172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="30084" checksum="F1F3236E179DDC27" modified="2017-01-18" version="1">MKRMSMIFKSKANRALDRMEDPRETLDYSYQRQLEMLQKVRRGVADVATSRKRLELQIQQLEQQQNKLTDQGKKALQVGREDLAREALTRRAGLDSQLSDLRVQYQNLQGEEEKLTLASQRLQAKVDAFRTRKETIKATYTAAEAQTKINEAFSGISEEMGDVGLAIQRAEEKTETMKARAGAIDELLASGALEDFSGPRDDIQAELDRMGAGTGVELELERMKAELGQGPAPKQLDPGAPQGQPQQAPQQQAAPQPPAQGQWPQQPGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S420</accession>
    <name>A0A1H5S420_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45094">
        <property type="protein sequence ID" value="SEF45094"/>
        <property type="gene ID" value="SAMN04489712_10163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF45094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7558" checksum="FB18334282D81785" modified="2017-01-18" version="1">MPWSWRLQRGDGGAATVPGLPEETFTTQADAESWLGLNWRELREAGVEQVTLLEDDVVVYPMSLLDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S6M6</accession>
    <name>A0A1H5S6M6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome aa3 subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SAMN04489712_10174</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45431">
        <property type="protein sequence ID" value="SEF45431"/>
        <property type="gene ID" value="SAMN04489712_10174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009283673" description="Cytochrome-c oxidase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="17">
        <location>
            <begin position="122"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SEF45431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="260" mass="28870" checksum="432C6BFCCA35663E" modified="2017-01-18" version="1">MRARRALTSAGALALLAMTATACSGEAARLGMPEPISDQADRVLQLWQGSWIAAFAVGGVVWGLIIWAVLFHRKRSDDLPPQVRYNLPIEMLYTAVPFVIIAVLFYFTARDQNYIEKTTNDNVAAVIDVHAFQWSWQFDYKESLAKDAKTVASVVGIPVDPNTADKVRVMIPAGQKVRFRLHSNDVIHSFWVPALLYKKDVMPGYVNEFEITANKTGLYEGRCAELCGVDHSRMLFQMQVVTPAEYQKFIAASKAAGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SDE5</accession>
    <name>A0A1H5SDE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47777">
        <property type="protein sequence ID" value="SEF47777"/>
        <property type="gene ID" value="SAMN04489712_101141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF47777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="52" mass="6022" checksum="7231DA9F68662E05" modified="2017-01-18" version="1">MTISPDEERPVDLVDDDIEILPDQTADDTDTGWGEWRGDSDSRLLEERPPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SQP0</accession>
    <name>A0A1H5SQP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52916">
        <property type="protein sequence ID" value="SEF52916"/>
        <property type="gene ID" value="SAMN04489712_101325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF52916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7603" checksum="C240B32E76603D01" modified="2017-01-18" version="1">MPQQGTVKWFNAEKGYGFIAVDGDGPDVFVHYSAIQSSGYRTLDENQRVEFEVTQGNRGPQADQVRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T566</accession>
    <name>A0A1H5T566_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57936">
        <property type="protein sequence ID" value="SEF57936"/>
        <property type="gene ID" value="SAMN04489712_101488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF57936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="17813" checksum="6B559EF856586753" modified="2017-01-18" version="1">MRVVVNYGLNHSRYIGSRRVRLPTNEEKLIARANKRAKAKSAAGKAKNKPSPEEKAANRARFLAEAQRIAVQMEEARAGGDVSGVLRLYGQAERSLFNAFGKKAAMGTELYETLQGHWMWARECEERERREQLEEKIRRYKEKVARQQGKERRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TNA7</accession>
    <name>A0A1H5TNA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, DUF2236 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64263">
        <property type="protein sequence ID" value="SEF64263"/>
        <property type="gene ID" value="SAMN04489712_101687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="52"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF64263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="339" mass="37329" checksum="F4A0C5B7DAF4282B" modified="2017-01-18" version="1">MIPLPHRALARTLAERFDGYFDTQVRSRFFRGLDFAGPVGDPGWFGPDSAVWYVHSHTPILSFGLACAAYLEGLDPSIYWMGVDHSRLTAKDAEGRPTGEFDIEGAAVRFGHSLSFFIGTAYGSTETAERLARTVRAMHHTVKGHRPDGLAYDADDPDWLRWNYATVVWGLATAHERYHPRPLRGKDLDGYYREFVRVGHALGGTDLPTTKAETLECLRAYLPRLAVTPGKAARTGPNLRDTPTTLLTGPFMDWAVRDTLPDWAARMVMHLPPNPVEGRARRTVLWLALNAPHAISGPIKEFQQAQARVAAGTTGAPTAPGYEPGTDPVRSRAEAEAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UXL0</accession>
    <name>A0A1H5UXL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maltokinase</fullName>
            <ecNumber evidence="5">2.7.1.175</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltose-1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_10279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.175"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.175" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79809">
        <property type="protein sequence ID" value="SEF79809"/>
        <property type="gene ID" value="SAMN04489712_10279"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="9">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="APH" evidence="8">
        <location>
            <begin position="246"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF79809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="472" mass="51822" checksum="FF2925D437DFC574" modified="2017-01-18" version="1">MRPPDRSIEQALIGWLPRQRWFAGKGRAITGVEIVTGTDMTGPAEDGPQLRHALVEVRQDGVRDLYQLLLGFRARLPDRLRYAEILALDGMHVYDAAHDPQLTAVLLECLAEQMDLGPLSFRRAPGAVIETGLVSLAGTAEQSNTSLVFGDAYIYKMFRRITPGVNPDLELNLALSERGCRHIPRLYGWAEMTVPGEGEGGEQRATVGMLSEFLRTASDGWQLATTSVRDLYGSDSDLPADQAGGDFAAEAERLGTATASVHRDLAEAFGVREVPAQALRAVAARMTEQLDTACAEVPELAAYAESIRSVYKDLAELGRPVPVQRIHGDYHLGQVMRTDRGWVLLDFEGEPARTLAERQAPAHPLRDVAGMLRSFEYAARFLLAGHHEPAAARGEDAGTTGLLESRAREWADHNRGAFCRGYAEGGGPDPDAHRVLLRAFELDKAVYEVRYEAHNRPTWLHVPLGSLPYLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V5J4</accession>
    <name>A0A1H5V5J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">2-oxoglutarate dehydrogenase E1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SAMN04489712_102175</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10483"/>
            <dbReference type="Rhea" id="RHEA-COMP:10484"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82589">
        <property type="protein sequence ID" value="SEF82589"/>
        <property type="gene ID" value="SAMN04489712_102175"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transket_pyr" evidence="15">
        <location>
            <begin position="904"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="809"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SEF82589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1244" mass="136022" checksum="DD75D91AA57888A8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V6X3</accession>
    <name>A0A1H5V6X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_102190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82973">
        <property type="protein sequence ID" value="SEF82973"/>
        <property type="gene ID" value="SAMN04489712_102190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
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        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="221"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF82973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="30945" checksum="1D3454D5F39B9989" modified="2017-01-18" version="1">MTEKTTLPDGGGMPGPADERPDTGVPDRARARALFERLHELPEGDPERQRVRDQLVELHLPLVEYLARRFRNRGEWLDDLIQVATIGLIKSIDRFDLERGVEFSTYATPTIVGEIKRHFRDKGWAVRVPRRLQELKLSLTKAISDLAQREGRAPTVSELAEHLQMSEEEVLEGLESANAYSTVSLDAPDSGDEDAPAVADSLGMVDDSLEGVEYRESLKPLLEKLPAREKRILLLRFFGNMTQSQIAAELGISQMHVSRLLARTLAQLREGLTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VB10</accession>
    <name>A0A1H5VB10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84404">
        <property type="protein sequence ID" value="SEF84404"/>
        <property type="gene ID" value="SAMN04489712_102242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="ABC1" evidence="2">
        <location>
            <begin position="105"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF84404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="468" mass="50949" checksum="4B1ED5DF11C1F341" modified="2017-01-18" version="1">MAGSTPIPDNGQVSDLPRRAVTRSAKLASLPLGFAGRAALGVGKRTLGKPAELVAAEIQQRTAEQLFKVLGELKGGAMKLGQMLSIFEAALPAEIAGPYRATLTKLQEAAPPLPAAAVHKVLAEGLGADWRELFESFDDRPAAAASIGQVHRAVWQDGRKVAVKVQYPGAGKALISDFNQLARLGKLFAVLMPGLEIKPMLAELKERVAEELDYTIEAESQSAFAKAYADDPDFRIPEVVAQSGNVLVTEWIDGTPLSKVISDGDQDERNHAALLYCRFLLSGPKRSGMLHGDPHPGNFRILEDGRLGVLDFGAVDRIPGGFQRRLGLLLRIGTMAEIDEVMQTLREEDFIRDGVEIDPESLQAFLAPITEPFVTETFAFSREWLRMMAARVTDLRPTNVVRQLNLPPEYVIIHRVLSAGTGVLCQLECEIPARAESLKWIPGFAEDEDGENDEDVQGVQDEDGELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WZB9</accession>
    <name>A0A1H5WZB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hva1_TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04565">
        <property type="protein sequence ID" value="SEG04565"/>
        <property type="gene ID" value="SAMN04489712_10316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hva1_TUDOR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG04565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7380" checksum="DFE6B3046668FCFA" modified="2017-01-18" version="1">MAEFSEGDRVSWRSHGGRAQGTVLKKITSDTEAAGRTVRASKDDPQYLVRSDHGGEAVHRPSALEKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X0N0</accession>
    <name>A0A1H5X0N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation-transporting ATPase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_10333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05113">
        <property type="protein sequence ID" value="SEG05113"/>
        <property type="gene ID" value="SAMN04489712_10333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009288943" evidence="9">
        <location>
            <begin position="26"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1386"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1439"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1471"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_C" evidence="10">
        <location>
            <begin position="1332"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="744"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="750"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG05113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1509" mass="156968" checksum="2060A9AB7CD02CCC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X7V2</accession>
    <name>A0A1H5X7V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA+-type ATPase, SpoVK/Ycf46/Vps4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07457">
        <property type="protein sequence ID" value="SEG07457"/>
        <property type="gene ID" value="SAMN04489712_103114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="416"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="675"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="954"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG07457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1190" mass="127740" checksum="9CBF8E4D69C54E5A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XJL2</accession>
    <name>A0A1H5XJL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trk system potassium uptake protein TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11665">
        <property type="protein sequence ID" value="SEG11665"/>
        <property type="gene ID" value="SAMN04489712_103276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="137"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG11665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23678" checksum="E5EDE892A06CE598" modified="2017-01-18" version="1">MADKDIPVVVIGLGRFGSSLALELARQGTEVLAIDHRPKVVQAMAGQLTHIATADATDIEALRQLGVPDFHRAVVGIGSDIEASILTTSLLVELEIADIWAKAVSRQHGRILERIGATHVVLPEHDMGERVAHMVGGRMLDYIAVDENFALAKTRPIREIVGTPLGETGLRRKHGVTVVSVKSEGEEFTYATPDTVLQYGDLIIIAGPIAKVERFPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XM01</accession>
    <name>A0A1H5XM01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12751">
        <property type="protein sequence ID" value="SEG12751"/>
        <property type="gene ID" value="SAMN04489712_103314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014636">
        <property type="entry name" value="RNaseH/PGlycerate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036922">
        <property type="entry name" value="RNaseH_PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG12751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="379" mass="41021" checksum="C69671CE4CE26CD5" modified="2017-01-18" version="1">MSASRRLVVEADGGSRGNPGPAGYGALVRDAVTGEVLAEVAEAIGRATNNVAEYRGLIAGLRAAAETDPSARVEVRMDSKLVVEQMSGRWKIKHPDMIPLALEAREVASAFAAVSYQWVPRNRNAHADRLANEAMDAAARGEPWVRKVHEDDSPAVAADPEPVAPTGPAWATATTAPTTTLLLRHGQTPLSVDKRFAGVGDVPLTDVGREQARAAARALKGHGLDAVVTSPLVRCRDTAAEVAAATGVPVRVEDGFRETDFGRWEGLTFAEVRERWPEEMNAWLADPAVAPPGGESFDEVARRVRIALDKLKVRYRHQTVLVVSHVTPIKLLVRDALQAPMGSLYRMHLDVSSLTRIDWYDDGPAVLRLLNDTHHLPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XS58</accession>
    <name>A0A1H5XS58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14619">
        <property type="protein sequence ID" value="SEG14619"/>
        <property type="gene ID" value="SAMN04489712_103387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG14619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="70" mass="7668" checksum="D8EBB8AAC032DF69" modified="2017-01-18" version="1">MTTAGTALGALPGLHTRPEQPSWALQRLAWLPIFAAVLALTWLAAHRFERPGRRRHRRPAAGAPPGGWHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XT61</accession>
    <name>A0A1H5XT61_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="10" type="ORF">SAMN04489712_103395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14843">
        <property type="protein sequence ID" value="SEG14843"/>
        <property type="gene ID" value="SAMN04489712_103395"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="197"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG14843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="472" mass="49847" checksum="A723CB6E2D04AAAF" modified="2017-01-18" version="1">MLAAGALPVLAFPRPELDWAAWALLVPGLLGLRAAPTAREAAVRGWWFGGGFLIAALYWTIPNIGPGLLLVAAVFGVLWAPWGWAARTLLPARPAAAMLVLPSLWVLNEYARSWHKLGGPWALLGATQWRHPAVLALAALGGVWLVGFAVVAVNTALTLAIIDRRVRAPALATALAVVLAGPLTYAVLHRPRPERTMTVALVQPGVVHGPAARLAAEERITAGLPRVDLVVWGESSVGFDLARSPDLRARLTALAARSELLVNEDARDARGRISKSSIVIGANGIRGRYVKTRLVPFGEYIPLRPVLGWLAHISRAAGQDRVPGTGAETLAAGGTRIGPLVCFESAFPDLGRALVRKGARVIVVQSATSTFQDSWAPPQHASLAAVRAAETGRPVVQAALTGVSAAFDAQGRRLAWADTDARGAVVVTLALPPAGARTPFARYGDYVIFVALAVTAAELSVTVVRRRRTLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XU41</accession>
    <name>A0A1H5XU41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase, RecQ-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15173">
        <property type="protein sequence ID" value="SEG15173"/>
        <property type="gene ID" value="SAMN04489712_103407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="69"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="283"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG15173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="753" mass="81854" checksum="48E5706EAAB9C6D8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XV02</accession>
    <name>A0A1H5XV02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15220">
        <property type="protein sequence ID" value="SEG15220"/>
        <property type="gene ID" value="SAMN04489712_103409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG15220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="65" mass="6616" checksum="46A4A2B856A2D3A4" modified="2017-01-18" version="1">MGASPGDRRHDGGTPEHPPARLPQRWVVILAVAGVTGAVLAARVDPVTGLTAGLAIVGLLHTVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y2F3</accession>
    <name>A0A1H5Y2F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid/cholesterol/gamma-HCH transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17790">
        <property type="protein sequence ID" value="SEG17790"/>
        <property type="gene ID" value="SAMN04489712_103509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="29699" checksum="EB4F274CB27ECF22" modified="2017-01-18" version="1">MGIFVDGGAARRLNSRLTWLDTLGDQLLFYLRALAWTPRALHRYTREIRRLLAEVSFGGGALGVIGGTIGVMVAMTLFTGTVVGLQGYAALNQIGTSAFTGFVSAYFNTREIAPLVAGLALSATVGAGFTAQLGAMRINEEVDALEGMGISSVPYLVTTRIIAGFVAIIPLYGMGLLSSYFASRMVTTLYNGQSPGTYDHYFDLFLSPVDVVWSFTKVLAFSVMVILAHCYYGFRATGGPAGVGVAVGRAVRTAIVLISVTDFFLSLAIWGATTTVKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YNS3</accession>
    <name>A0A1H5YNS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25779">
        <property type="protein sequence ID" value="SEG25779"/>
        <property type="gene ID" value="SAMN04489712_104107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG25779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7700" checksum="8BF43CCF3948E677" modified="2017-01-18" version="1">MDSLFRLLAEGGPVTWVAALGAAVIVALVFYLGVAMFATLISRDQRRGKMRYRVFLDLLELFQRRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YPG1</accession>
    <name>A0A1H5YPG1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_104115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25999">
        <property type="protein sequence ID" value="SEG25999"/>
        <property type="gene ID" value="SAMN04489712_104115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HsdM_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="4">
        <location>
            <begin position="152"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG25999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="661" mass="74707" checksum="C2DB071D511630CA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YQR3</accession>
    <name>A0A1H5YQR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-[acyl-carrier protein] reductase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25696">
        <property type="protein sequence ID" value="SEG25696"/>
        <property type="gene ID" value="SAMN04489712_104104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG25696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="25406" checksum="BD8C8733F5FAECBB" modified="2017-01-18" version="1">MKTAVITGAGRGIGRATAFALARDGYAVAVGYHRNAESAAEVVDEIDRNGGHAAAFALDVADRDQCAEFVRAAGERLGPVRAVIANATGFGSASPSLGKALETPWHTYEQMFAARVGSLLALVAAARPQLNGGGRVVTTVSTGTSRHVPGYAAIAAAMAAAESVVRYLAVELGRDGITVNLVSGGVVATDALRDISPDPERLLAAAARATPLGRAGTPQDLAEVIAFLCGEGAAWITGRSIVADGGNSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YRM3</accession>
    <name>A0A1H5YRM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26753">
        <property type="protein sequence ID" value="SEG26753"/>
        <property type="gene ID" value="SAMN04489712_104148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043993">
        <property type="entry name" value="T4SS_pilin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18895">
        <property type="entry name" value="T4SS_pilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="130" mass="13383" checksum="5C16AC83DAC1E313" modified="2017-01-18" version="1">MPTHPSSPRLPGRRRSVGRGRLAGAVCLWSAGVAVSALTVPGIAEAGTRLAEVASLEEVITNLRDVIVGLLVGLATLFATIGGVRYILAGGDPSEVEAAKRTLRYAAIGYGVAMLAPLLVGILQRIVGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YUI8</accession>
    <name>A0A1H5YUI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27929">
        <property type="protein sequence ID" value="SEG27929"/>
        <property type="gene ID" value="SAMN04489712_104201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG27929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="357" mass="38481" checksum="8FC4231A17869DA9" modified="2017-01-18" version="1">MDGQVWKSAAHGGPDAPGTLVDLAALGDPEAFAGLLRAPAATRGELLDDALDKDMRPLVAQALHVCDSGSTEEILLALKVLDAVAIAEECPELLPDTVRVLTGLCRPDQDVEVLAAALPLYGAHVPGPSAAQVLLAMSGHPDSRVRAGAVDGIEYFTDEGTFPPATMDLAERLARMLAEDPDAQVRLAVAEAFGMMENWAGFQVGWVHHMVAALARAVGVDQDPAVRRAAAKNLAQTWQAARPEAAEALRPYIGDGDPYVAAWALARLACLGDPAALDRLWTVLAAPDVHREYLSAATELFVSYRGDASRRDRRRLRGELKRLRKQGWANAPTDEPNWSPQARDDYLKILISRLSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YUU3</accession>
    <name>A0A1H5YUU3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ORF">SAMN04489712_104194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27778">
        <property type="protein sequence ID" value="SEG27778"/>
        <property type="gene ID" value="SAMN04489712_104194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="196"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG27778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="674" mass="73532" checksum="A0EDCCD4CC65E62E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YYP2</accession>
    <name>A0A1H5YYP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_104266</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29409">
        <property type="protein sequence ID" value="SEG29409"/>
        <property type="gene ID" value="SAMN04489712_104266"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG29409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="34994" checksum="44C04B6340DE903A" modified="2017-01-18" version="1">MTARFPVARPRRLRRTPAMRRMVAQTRLAPADLILPMFVKEGIAEPQPVASMPGVVQHTPDSLRKAAHEAVDAGVGGLVLFGVPAVKDGTGTAADDPDGIVQRALRDLSSDLGEATVLMADLCLDEYTDHGHCGILTPSGEVDNDATLERYASIAVAQAAAGVQVVAPSGMMDGQVGAIRTALDEAGYRDVAIMAYSAKYASAYYGPFRDAAECAPQFGDRSAYQQDPANADESLREVMLDLDEGADLVMVKPAGPYLDIVRRVRDAVDVPVAAYQVSGEYAMVEAAAAQGWVDRERVIMESLTGIRRAGADLVLTYWATEVARRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z276</accession>
    <name>A0A1H5Z276_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chloramphenicol-sensitive protein RarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_104306</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30388">
        <property type="protein sequence ID" value="SEG30388"/>
        <property type="gene ID" value="SAMN04489712_104306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="10">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="10">
        <location>
            <begin position="151"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG30388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="324" mass="34704" checksum="97F592F12ECC21F3" modified="2017-01-18" version="1">MTGVTDRRGLVSGIAAYVLWGLFPLYWPLLKPAGAVEILAHRVMWSLAAVLVVLAVLRRWRWIRALSPRRLGLLVVAATVISFNWGTYIYAVNTGHTIEAALGYFINPLISVLLGVLVFRERLRPWQWSAVGLGALAVVVLAVDYGRPPWIALVLACSFGTYGLVKKFADMPSAESLAAETAVIFLPALGYVLVLEAHGTAAFAHEGTVNALLLVGGGLVTAVPLLLFNTAAVRIPMSTLGMLQYLAPVLQFLIGLLVQHEPMPASRWIGFLLVWAALAILTFDGLRAAHRSRLPATPEKAPGNAPGNAPEGTPGRLSPAGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZCJ9</accession>
    <name>A0A1H5ZCJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ORF">SAMN04489712_104470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33780">
        <property type="protein sequence ID" value="SEG33780"/>
        <property type="gene ID" value="SAMN04489712_104470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="29"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="139"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG33780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="345" mass="35050" checksum="AB2835ED602E90BE" modified="2017-01-18" version="1">MIRDSEPLVLGIETSCDETGVGVVRGTTLLADAIASSVDEHARFGGVVPEVASRAHLEAMAPTVERALAEAGVAFADVDAIAVTAGPGLAGALLVGVAAAKAYALALGKPLYGVNHLAAHVAVDQLEHGPLPKPCVAMLVSGGHSSLLLVPDVATDVRPLGATVDDAAGEAFDKIARVLGLGFPGGPVIDRMAREGTADAIAFPRGKYDDGTYDFSFSGLKTAVARWVEARERAGEPVPVADVAASFQEAVVDVLTAKALAACRAHGVKDLLVGGGVAANSRLRALAAQRCEAAGVRLRVPRPKLCTDNGAMVAALGAELVASGTVPSELDLPADSALPITTIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZUY0</accession>
    <name>A0A1H5ZUY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40298">
        <property type="protein sequence ID" value="SEG40298"/>
        <property type="gene ID" value="SAMN04489712_10526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG40298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="36882" checksum="1B67FDB3199F52FF" modified="2017-01-18" version="1">MTSEPTKGSFGPLPEHISEHRADHVGSEFDTIVDLCRQALQQGALQYVAYYIRGNWQVWLDVFDPRDPFSDLSPEQIKRERDSLLTGGQQLHFVVARLDQAFTPVQRGRLIRCVFDVGAGALLYFSPSPGEYLVGATLHDERISGADASMVWLSEEIRLARGFGGTPNYAGEHSRYEVNVRRGDIVDDEDVYVDTANPGGAPSDMLDLCRAVLDPEAVHYVACFQGAEPICSVDLLAHPGLAALTFGTDSRDRRRHYQRIGKLLYLVTNRLDRTLLPLLGGVLGRTVLDVEAGALFYLRASGDRFVIGITLDQAKVAVADEQLGELARALAARPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZYG7</accession>
    <name>A0A1H5ZYG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin binding protein transpeptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40737">
        <property type="protein sequence ID" value="SEG40737"/>
        <property type="gene ID" value="SAMN04489712_10548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292042" evidence="1">
        <location>
            <begin position="25"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="3">
        <location>
            <begin position="34"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="247"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG40737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="517" mass="53817" checksum="E5C189FF8EE0B3CC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A0E0</accession>
    <name>A0A1H6A0E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42189">
        <property type="protein sequence ID" value="SEG42189"/>
        <property type="gene ID" value="SAMN04489712_105122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004597">
        <property type="entry name" value="Tag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00624">
        <property type="entry name" value="tag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG42189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="195" mass="20934" checksum="E80311786271B575" modified="2017-01-18" version="1">MSAAVVGADGLGRCPWALSTPDYVAYHDEEWGRPVTDDQGLYERLCLEAFQSGLSWITILRKREGFRAAFKGFDMAEVAGFGPEDVARLLADTAIVRNRAKIEAAVANARAALDLPGGLAALVWRHADHDAPAPRTTADVPASTAGSRALAKELKKHGFTFVGPTTAYALMQACGLVDDHLADCHRRGAYTALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A8P1</accession>
    <name>A0A1H6A8P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44405">
        <property type="protein sequence ID" value="SEG44405"/>
        <property type="gene ID" value="SAMN04489712_105250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="19599" checksum="9B3407FFC9201D2D" modified="2017-01-18" version="1">MIDIAADLLAHADRYTASARAVMDAAPAPLPDLETARAELLEQLADVDRRITARTAAEKRCADLARVAARLRDLAGQHQEETAPPPAPVGDALAAALRAGGEQVPVPSPLSPETARWSEDGASEPLGEPVAGHATTQTRPEPPQEPRRERPFPGEGVPGPLGVGGGDGAAVAPAHRPPGGGVTQEEQTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZY1</accession>
    <name>A0A1H6AZY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53597">
        <property type="protein sequence ID" value="SEG53597"/>
        <property type="gene ID" value="SAMN04489712_106103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293184" evidence="1">
        <location>
            <begin position="22"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="45876" checksum="A77E00B512F38DD2" modified="2017-01-18" version="1">MGIATMASAAALTLVALTAVACGDGGTSAGGPKELLYWASNQGTSLDHDRKVLEPELAKFTRKTGIKVKLEVIGWPDLLNRILAATTSGRGPDVLNIGNTWSASLQATGALLPFDDATLAKVGGRDRFLGPCLAATGAQGKPPAAVPIYGQAYGLYYNKKLFREAGIDRPPATWNELIETGKKLTKPGQWGLTLQAGQVTENAHHAAILGAQHGARFFDGEKPTLASDPAADAIKQYLDLMQVHKIVNPSNVEYTDTAKSLKDLADGKAAMFMNQASAGSFEAVGMKMDDLGVAPIPLPDQPPPGGRRVNSFVAGINLAVFKNTRNLDGALEFVKFMTSTEEQALLNKTYGSLPTVKDAYTDPAFQTEQVKVFQGVLSGTAEPMPQVPQESQFETLVGTAMKSMFADVASGRTVDAAQIKARLAQADQQLAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B1T7</accession>
    <name>A0A1H6B1T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54564">
        <property type="protein sequence ID" value="SEG54564"/>
        <property type="gene ID" value="SAMN04489712_106165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293377" evidence="2">
        <location>
            <begin position="27"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG54564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="25330" checksum="596502D39A4FEA9C" modified="2017-01-18" version="1">MMRSRGPALATGLAAGLMLTGGAASASPQPAPSSAPSPTAAATEDSLARVCAYGQMATAGLGPWGPERPQLPIDNVVHRDMESFVAAKPQVRPLRTHQFVSRDADGRAVQIRCKGKSADHINTVHGDGTASGEGACGAINRTTLRSVGASLSAPERASAVHDPAEVVVDEDTQTLTGGEWTQEFSSTAVEDGVLHLRAYALVVEWLDPRWQNLPEAFRGVHYCTLIAPGHLRRVLLGEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2L1</accession>
    <name>A0A1H6B2L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfur acquisition oxidoreductase, SfnB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_106158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54457">
        <property type="protein sequence ID" value="SEG54457"/>
        <property type="gene ID" value="SAMN04489712_106158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="3">
        <location>
            <begin position="127"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="5">
        <location>
            <begin position="236"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG54457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="432" mass="45537" checksum="B9C9D6A41FEB51F0" modified="2017-01-18" version="1">MAHLIRDDTEAVEVARELAARLAVGAARRDADRTPPVTELAELSESGLLGITVPREHGGAGVGAVTLGEVFRLLSAADPSIGQIPQNHFFFVRVLAENGTGEQRAFFYAELLKGRRFGNALAEAGAANAFEFRTRLTRRPDGDYTVSGTKSYATGSPFAHWIPVYATDEEGRVHAVFIPRDAPGLEVVDDWSGFGQRTTGSGTVHLNDVRVPADRVVPHYRTFERPEVFGAFGQYMHAAIDVGIAGGALAEGASFVRASARPWPEAGVDRLAREPLVIQKFGELALLVRAAEALLVRAGQALDAALGHPSPAGPERSSGDPEPAAGAGDPAAAPRSGPGGSGGFGSLTAEDPVAEASLAVAAARAQGDIAALTVSSEVLGVVGARASLERYNLDRHWRNARTHTLHDPRRWKLQHLGDHALNGVAPPPNGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6R0</accession>
    <name>A0A1H6B6R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56529">
        <property type="protein sequence ID" value="SEG56529"/>
        <property type="gene ID" value="SAMN04489712_106319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG56529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="13033" checksum="2A62C280B6BB0368" modified="2017-01-18" version="1">MLGIDHCLDHVMAIPGAQRVTLVDGASGLAVAAAGRADLADQHEDAAGTTDVVRAVLAAPSLRTSGTGEDVEDIIVSGAHGYHLLTLLGTAFDGRLFLHVHIDGGAGNLALARIRMREIVREMTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B780</accession>
    <name>A0A1H6B780_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55986">
        <property type="protein sequence ID" value="SEG55986"/>
        <property type="gene ID" value="SAMN04489712_106275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="17631" checksum="2C3B3E62439D2CC7" modified="2017-01-18" version="1">MLTTSAAPVRTVPDLAALLNHAGHVLHTRLAAALDEIDVTPRAICVLIHAMEAERTQAELAELADLDKTTMVVTVDALEKAGLAERRTSSTDRRARIVSVTEAGARKARAGVEIVDAVHRGVLEALPEEEREVFVSALERLVAGHLAVPAESGRPVRRARTARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BH82</accession>
    <name>A0A1H6BH82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative flippase GtrA (Transmembrane translocase of bactoprenol-linked glucose)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_107106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60050">
        <property type="protein sequence ID" value="SEG60050"/>
        <property type="gene ID" value="SAMN04489712_107106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG60050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="17205" checksum="B491B41851635985" modified="2017-01-18" version="1">MSTLQRSRAAAALAPVARSRLHFVRELLRFGTVGTVGTVITIGGANLMRGRFWESPVTTVLVPTMLATLFSYLANRHWTFRHHDSDGSGREMALFFGLNGIGMLIQACCTAFTFYTLGLHDALSYNLALLVGLALASAWRYWSYKKWIFTRSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJW1</accession>
    <name>A0A1H6BJW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycolate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60983">
        <property type="protein sequence ID" value="SEG60983"/>
        <property type="gene ID" value="SAMN04489712_107173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="482" mass="51080" checksum="8B6C294BF5A758A3" modified="2017-01-18" version="1">MGLEGLARRFTEVLGDERVITDPVRLRTYECDGLTYHRAMPGVVVLPDTAEQIAAIVRECVTAGVPYVARGSGTGLSGGALPRTDGVLIVTSRMRRILEIDPANQRAVVEPGVINLELTKAARPHGYYFAPDPSSQQICSIGGNVAENSGGAHCLKYGFTAHHVLACEIVTPDGEITTIGRDTGGYDLLGAFVGSEGTLGITTKITVRLTRLPQTVQTLLAAFDSIEAGGTAVSAIIGAGVVPAAIEMMDALSIEAAEAAVACGYPPGAGAVLIVELDGPAAEVEHQFAEVERLCRRAGAFEIRIATDDAERNLIWKGRKSAFAAVGRISPAYLVQDGVIPRTALPRVLARIDELSRESGVRVANVFHAGDGNLHPLVLFDDSEPGAGQRAEELSGRILDLCIEHGGSITGEHGVGVDKSRHMPRMFTETDLDTMQMVRCAFDPAGLCNPGKVFPTPRLCGEVPGVRKEPHPLVQQGKAELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJX0</accession>
    <name>A0A1H6BJX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60715">
        <property type="protein sequence ID" value="SEG60715"/>
        <property type="gene ID" value="SAMN04489712_107151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021447">
        <property type="entry name" value="DUF3097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11296">
        <property type="entry name" value="DUF3097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG60715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="30606" checksum="D2002A6D76F1DC80" modified="2017-01-18" version="1">MRSKDYGDDVLAGDWRRPRKGQIPQIPAERDLVVEDPGSGFCGAVVACDKYGVTLEDRFGERRVFPLAKAGFLLEGRPVTLVRPQRAAEGARRDPARSASGSVVVQGLRARVAKESRIYVEGLHDAELVEKIWGHDLRVEGVVVEYLEGIDDLPAVVEEFGPEPGRRLGVLVDHLVDGSKESRIAAQVSSPYVLITGHPFIDIWEAVKPSAVRIGAWPKIPRGVPWKEGVLEALGWPGDVRAGWQRILGSVNSYTDLEPELLGRVEELIDFVTAPEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJX1</accession>
    <name>A0A1H6BJX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycolate oxidase FAD binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60993">
        <property type="protein sequence ID" value="SEG60993"/>
        <property type="gene ID" value="SAMN04489712_107174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="407" mass="41615" checksum="C3061E6EA9D0E252" modified="2017-01-18" version="1">MSDVLSALGEVCADVREGLPEEGVLGVLPAMVAAPRTVAEAAEVMRVAAERDLAVVPRGNETRLDWGRPPARCDLLVDTTGLDRVIEHAAGDLVVKVEAGLTVDRLAEVLAAHGQRLALDVPLPGSTVGGTLAAAAGGPSRLLYGSARDLLIGVTMVRADGRIAKAGGKVVKNVAGYDLGKLLTGSFGTLGLIVEAAFRLHPLPEARAYVTAGFGGVREAYQAVQQVLHSHHVPSAIEVDTVIGGPVTVGVLVEGVQQGVGARAAAVAELLGPAADVADAPPDWWGAYPGGSTLVEVTAPPTALPRIVAELAEGGCAGAVLRGSAGVGGWHVGLEAGEPPAVAGPLARLRRVLAPLPGGAVVRYAPEAVREEIDLWGPVPALPLMRRVKDQFDPGHRLSPGRFAGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BK68</accession>
    <name>A0A1H6BK68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61022">
        <property type="protein sequence ID" value="SEG61022"/>
        <property type="gene ID" value="SAMN04489712_107177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="108"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG61022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="568" mass="62812" checksum="E1E7966E609832D7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPD6</accession>
    <name>A0A1H6BPD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoadipate enol-lactonase / 4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_107271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62076">
        <property type="protein sequence ID" value="SEG62076"/>
        <property type="gene ID" value="SAMN04489712_107271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042952">
        <property type="term" value="P:beta-ketoadipate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012788">
        <property type="entry name" value="Decarb_PcaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026968">
        <property type="entry name" value="PcaD/CatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02425">
        <property type="entry name" value="decarb_PcaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02427">
        <property type="entry name" value="protocat_pcaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="196"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="3">
        <location>
            <begin position="293"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG62076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="389" mass="40316" checksum="5559F23A0C166909" modified="2017-01-18" version="1">MPSHDGTGVLNHRLDGPASGPPVLLGPSLGTSLAVWEPQVPALARARRVVRWDLPGHGGSPAALLPAGSTIADLGRLVLDLADSLGVGRFAYAGISLGGAVGAWLAVHHPDRISSLVMVCSSARFGEPEGWHERAALVRAKGTGPLADTAPARWFTPGFVAGSLVDDIRAADPEGYAACCEALAGYDLRDALDRITAPTLVIAGREDQATPPAHARELADGIPGAGLVEVPGAAHLAGVERPAPVTSALLGHLAAGSDDGSRHAAGMAVRRAVLGDAHVDRAVARTTGFTAPFQDFITRYAWGEIWTRPGLDRKTRSCITLTALVAHGHHDELAMHVRAALRNGLTPEEIGEVLLQAAVYCGVPAANSAFAIADRVLREEGEGPLNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPU1</accession>
    <name>A0A1H6BPU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62417">
        <property type="protein sequence ID" value="SEG62417"/>
        <property type="gene ID" value="SAMN04489712_107295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021398">
        <property type="entry name" value="DUF3037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11236">
        <property type="entry name" value="DUF3037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG62417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="124" mass="13351" checksum="752B55D6DEC5C37E" modified="2017-01-18" version="1">MSVFEYAVLRVVPRPERGESMNVGVVVHCRAVDFLGCRLHVDEGRLRALDPALDLAGVRSALHAVECVCRGGDEAGQAGGESPGSRFRWLTAPRSTVLQPGPVHAGITEDPAAELERLLDLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BWC9</accession>
    <name>A0A1H6BWC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RsbT antagonist protein RsbS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64990">
        <property type="protein sequence ID" value="SEG64990"/>
        <property type="gene ID" value="SAMN04489712_10869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13486" checksum="3BE4F049AB24DE96" modified="2017-01-18" version="1">MERVPILKVGDVLLISIQTDLEDRTALALQEDLAEQIVRTGARGVVIDITAVEIVDSFIGRMFATIAAMSRLLDARTVVVGMRPAVAITLVELGLSLGGVHTALNLEKGMRLLAAPDPGGPPGTMSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C389</accession>
    <name>A0A1H6C389_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67470">
        <property type="protein sequence ID" value="SEG67470"/>
        <property type="gene ID" value="SAMN04489712_108290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294410" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG67470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="70" mass="6863" checksum="8AFEEF817C7F443F" modified="2017-01-18" version="1">MTRGMGTALGIAVVTLTLHLAGGRAALAVLTAVALLAALTATTASTSPARTPPDRSPTPGRRESGGNGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CHX0</accession>
    <name>A0A1H6CHX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72611">
        <property type="protein sequence ID" value="SEG72611"/>
        <property type="gene ID" value="SAMN04489712_11019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG72611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="404" mass="43895" checksum="9137AE97A2D32433" modified="2017-01-18" version="1">MDEIDALRGMRTALTREEAPDRLAQRIDWRSARPAAEAPRRRGRLKMPLVSLATAAAVSAAAVAVVSLASDERPPGGPSSPTVLTGNALLVAATNAEKAPTGRYWHTKRVAGKVYAVGKTAADHYKVDTSREYETWVDRDGKSHSFMTDRPARPVTAEDRRRWQAAGSPDEILAPDPDGVMVSLFVKSLGPRSPMPSPPDAYSFHGLTVRQLAELPTDAKALEKTLLGLKGNWHAYSKDFSQRPVREPIRSLRGAERVRALSDVAGDLLANQPVPPGVRAAAFKMLAGLPGVTVKGQGTDPLGRTGTVVSLPLETTTPLGIYSAPKQLGTYRRQWIINPANGTLLAVQDLVATPPKGSRRLPPGDDGKPRRLTVDYQPDRFHRPGEVSSYEVYTVTEWTDTQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJ82</accession>
    <name>A0A1H6CJ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SAMN04489712_11034</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72775">
        <property type="protein sequence ID" value="SEG72775"/>
        <property type="gene ID" value="SAMN04489712_11034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="183"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="320"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEG72775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="414" mass="45784" checksum="92CAD7A1574B743A" modified="2017-01-18" version="1">MRHLGLLVLSVVPYRLIGVSRYRLQPTPAQEQALAGHCAHARYVWNLAVEQHAHWKPGRKSAPGFAEQCRQLTQARAGFAWLAAGSIIVQQQALKDFAEAMANFFAGTHRRPTWRRRGRREGFRIVAVKPDHVRRLSRRVGEVKVPKVGWVRFRWSRAVPEGVKSYRITRDAAGRWHVAFAAVPEPIPAPGTGEIVGVDRGVTVSAALSTGELLNVPGLRETEAKRLHRLQRKLARARRGSNRRAKVKAAIARLKARESDRRKDWVEKTSTDLACRFEVIGVEDLNIGNMARSAKGTVERPGRNVRAKAGLNRGILAGGWGLLAERLEHKAPGRLVKVNPAYTSQRCSACGVMDRRARESQAVFRCRSCGYTGNADVNAAKNIKLAAGRAVSAREGPRVTGPTHREPQPVLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKL9</accession>
    <name>A0A1H6CKL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73544">
        <property type="protein sequence ID" value="SEG73544"/>
        <property type="gene ID" value="SAMN04489712_110123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="20770" checksum="2077B7BCAE04153A" modified="2017-01-18" version="1">MRAALGCFSRDGVAGTPLGRLLSESGVSAGSFYHHFAGKEQVAAALYVETLRLFQEGFLRELRRHADPREAIAACVAFHIGWCAENPDRARFLFTERPPGRDEEGGRDLAAQNRTFFADVLAWWRPHEYHGVLRHIDVTTGCVLWLGPSQELCRMWLTGQVPQPAPDQIALLGEAAWQCLRRPDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CN89</accession>
    <name>A0A1H6CN89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74489">
        <property type="protein sequence ID" value="SEG74489"/>
        <property type="gene ID" value="SAMN04489712_110231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295024" evidence="1">
        <location>
            <begin position="38"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="34723" checksum="68F170B7D5B76861" modified="2017-01-18" version="1">MNAFRPTRPTRRLRTRLITITVALAITTGLTNTTGSATTTGLAGTNVLTVTTGSTGANDPTGANVEAAGAAPALPVQDRFQALGPAPVTTGRATDAAGRTYTLHHPSNLTDDGFANPIVTWGNGSNAGCADYAATLAHLASWGFVVICADSGATGWGTRIWAAVQHLIAENARDGSVFHDRLDTTRIGAAGHSQGATGALNANVLSNGAITSTVPLAFVDPWWHVPARQRPDLPKVKNPVFLVSGATDFLTFQSRQQTYFDRLTAPAAKAAVVGKGHNGMVRAATAYTTAWFLYTLRDDAFARGAFAATDQTTPEIRRNPAWTGWAAKDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRT4</accession>
    <name>A0A1H6CRT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW, lipid II flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75749">
        <property type="protein sequence ID" value="SEG75749"/>
        <property type="gene ID" value="SAMN04489712_11178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG75749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="514" mass="54499" checksum="07D7EFAE1EC464D2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CU08</accession>
    <name>A0A1H6CU08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76571">
        <property type="protein sequence ID" value="SEG76571"/>
        <property type="gene ID" value="SAMN04489712_111180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295199" evidence="1">
        <location>
            <begin position="28"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="15428" checksum="094447DBF1CFF0CB" modified="2017-01-18" version="1">MMKRLITVGLASIALGGALAAAPPAMAADRGGRNTAVPVIADRYARHHDCTTGGGHSRCYDGYPGGYSHAGGQGGYGGYGGYGRGYDGYGRHGSYGGHGHHGRSHRHPDSWHTYPGHWHWYRHHRSPWHSYHRHVHYDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVM8</accession>
    <name>A0A1H6CVM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76466">
        <property type="protein sequence ID" value="SEG76466"/>
        <property type="gene ID" value="SAMN04489712_111167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG76466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="40" mass="4118" checksum="A301D06C78A75CB3" modified="2017-01-18" version="1">MFFAAGTRPLADLGPLSAVSAAFPTSALFSALASYDGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVQ9</accession>
    <name>A0A1H6CVQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76773">
        <property type="protein sequence ID" value="SEG76773"/>
        <property type="gene ID" value="SAMN04489712_111205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295270" evidence="2">
        <location>
            <begin position="27"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="277" mass="28610" checksum="267AC8574A014E5A" modified="2017-01-18" version="1">MRLLKQLVVVVVVAAAGSAGVGAVQWDPVLTLVLGVAAAVLTLLAYRWVVRRTEHRAPAEVALKGAGGAVTRGMLIGFAMFGAVIVNIAFLGHYRIDGPGSTAGAVALLGFMAAAAVTEEVMFRGVLLRIIEERIGSWMALALTGLVFGLMHLPNPNATLWSSLAIAIEAGGMLAAAYIATRNLWVPIGLHFAWNFAGAGIFGTAVSGKDAPEGLIEGVTSGPVLLSGGEFGPEASLYAVGAGAVLTIVFMWLARRRGTIVPLRRSARAAATATLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CWF6</accession>
    <name>A0A1H6CWF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted dithiol-disulfide isomerase, DsbA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77167">
        <property type="protein sequence ID" value="SEG77167"/>
        <property type="gene ID" value="SAMN04489712_111258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="35"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="245" mass="25792" checksum="7B8682E6073F7BE1" modified="2017-01-18" version="1">MRSLSRGLAGLPSCRAGSRRWNAPQASPVDLGVNVEIFSDVVCPWCYLGQARFRAAVARFAGEVRVTWRPFQLDPGAPATATPAADHLAAKLGGPERVAAAHDRLRALTAAEGLPFAPEKALRVNTGDAHRVIALAGRAGVQDAVVERLFRAQHAEGRDIGDAGTLAELAAEAGLDVAAVRTLLDSDEGVAELEQDLARARALGINGVPFFLFEEKWAVSGGQPTEVFEGALQEVASNLTAGNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZX6</accession>
    <name>A0A1H6CZX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78582">
        <property type="protein sequence ID" value="SEG78582"/>
        <property type="gene ID" value="SAMN04489712_11295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="32016" checksum="B91FC8C67FC46EDF" modified="2017-01-18" version="1">MIDRAGLAEFLRRRRESLQPEDVGLPRGQRRRTAGLRREEVATLCHISADYYSRLERERGPHPSEQMIASIAQGLHLSLDERDHLFRLAGHNPPARGATSEHISPGMLRIFDRLTDTPAEIVTELGETLRQTPLGVALTGDTTRYTGPARSIGYRWFTDPATRALYHPDDHALHSRVFASGLRAMVTLRGPGSRAAHLMELLLARSEEFRAIWNKHEIGIHYNSVKRYMHPEVGALELTCQTLLDPEQSHILLVYTAVPGSESHEKLQLLSVIGSPNIIPQTAPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZX8</accession>
    <name>A0A1H6CZX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78334">
        <property type="protein sequence ID" value="SEG78334"/>
        <property type="gene ID" value="SAMN04489712_11264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="8">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG78334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="547" mass="60899" checksum="E4B2E1DAB75DA64B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D279</accession>
    <name>A0A1H6D279_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_112176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79164">
        <property type="protein sequence ID" value="SEG79164"/>
        <property type="gene ID" value="SAMN04489712_112176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG79164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="15931" checksum="7CC69B4704D41EC0" modified="2017-01-18" version="1">MPATIPVRGSVAIPETELRWRFSRSSGPGGQHVNTSATAAELSFDVAGSPSLPEPYKRRALERLAGRLTGGVLTIRAEEYRSQLRNRDAARARLAALLAEATAPPPKSRRPTKPSRRVHERRLESKRRRGAVKRERSGRWQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5B7</accession>
    <name>A0A1H6D5B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80451">
        <property type="protein sequence ID" value="SEG80451"/>
        <property type="gene ID" value="SAMN04489712_11383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="19873" checksum="50B95D24FDCC9189" modified="2017-01-18" version="1">MGFETTVLLLTWVAIALLAFVVSGLVRRVHHLGTGVRTAELGPAPGSAAPQFGRLTAGLSPGPSPGPSPGRADRTLLLFLDADCGVCPQVLAELRDVLDGSGRTLPVAALFADRALEGGHEGIEVFAGEAGLFEEYRIPAVPFAVLADGSGRVRTARPVGSPGALRDLLETVLETLPETAVGRQHAPVDGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7L0</accession>
    <name>A0A1H6D7L0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81329">
        <property type="protein sequence ID" value="SEG81329"/>
        <property type="gene ID" value="SAMN04489712_11427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="108"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG81329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="407" mass="44350" checksum="AE3BA8DD679A171C" modified="2017-01-18" version="1">MTAPAIEDLLRELTPQVLGALIRRYGRFEECEDAVQEAVLAAAVQWPAEGVPDNPRGWLVAVASRRLIDQMRSDHARREREWATAAEAAPAEAAPEVPDIDDTLVLLFLCCHPTLTPASQTALTLRAVGGLTTAEIARAFLVPDATMAARISRAKQRIRAAGSSFRLPDGAEREERLRVVLHVLYLIFNEGYTASSGSELHRADLAHEAIRLTRMVHTQLPEDGEVTGLLALMLLTHARRTARTTAAGDLVPLDEQDRTKWDRGLIGEGLELIKASLAGSTLGPYQLQAAIAATHADAATATETNWPQVHALYLILERIAPNPMVTLNRAIALAEIEGPPAGLALLSTLDSDERMAGHHRLLSVRAHLLERTGDAAGAYEHYRRAAKSTASIAEQRYLESRASRVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8D2</accession>
    <name>A0A1H6D8D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81482">
        <property type="protein sequence ID" value="SEG81482"/>
        <property type="gene ID" value="SAMN04489712_11467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295624" evidence="2">
        <location>
            <begin position="49"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="291"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG81482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="435" mass="46443" checksum="25201D8258363AD5" modified="2017-01-18" version="1">MPALRSRHPVRSVPGAGRLRDVRRTPAALASTATLMALSVAVAPAATAGESVDAALEWYDTTAATIAAAGAPTQSTNSRTWAISWLAAARALRAAPAGVNRRDYQDAALAGAVHTSLVALVPARAQELDAALRRTLERIPDGPAEERGVADGQRRARTVLASREGDGLDPASVNSPYPTPQPGPGIWQPTPPTYSPAVQAGNRAARPFLLERADQFRPGPPPALGSGRYRADLAEVRAYGSTDSTARTPRQTETATFWLGSSLTLYTGPLRVALARSHRPAAERATLVALFHVALVDTQIATSDTKYAYLRWRPVTAIRSADIDGDPATSPDPDWTPLHTTPAHPDYPSGHNTYSGAAEQILTALVGPRTAPFSLTSPTAPGVTRTYTDWRTLTQENVDARVWSGIHTRSADTVGVDLGRQVARHTLRHADRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DA38</accession>
    <name>A0A1H6DA38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette, subfamily B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_114117</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81683">
        <property type="protein sequence ID" value="SEG81683"/>
        <property type="gene ID" value="SAMN04489712_114117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="39"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="357"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="390"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG81683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="616" mass="65326" checksum="A5CD87A0C4D44FBA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAR1</accession>
    <name>A0A1H6DAR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81556">
        <property type="protein sequence ID" value="SEG81556"/>
        <property type="gene ID" value="SAMN04489712_11483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG81556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="35823" checksum="0784D19BD039F14B" modified="2017-01-18" version="1">MTTGEPAVAVAGLVKRFGDVTAVQGIDFTVASGEIFGFLGPNGAGKSTTISMLCTLLRPTAGTAQVAGHDVLRERDDVRRNIGLVFQDPTLDGYLSGEQNLRFHAELYGVPRAAVADRMRQVLEMVGLWERRRDKVQTYSGGMKRRLEIARGLLHSPRVLFLDEPTVGLDPQTRASIWDYIRQLQAAEQITIFMTTHYMEEAEFCDRIAIMDSGRIVALDTPEALKASVGKDRVQLHTDDAEAAIAALKERFDLDAAVREGAVTFAVPGGEEFVPRLFAELGMPIRSVSVARPSLDDVFMSYTGTTIRDAEGSSRDWMRMAARGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBJ6</accession>
    <name>A0A1H6DBJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82827">
        <property type="protein sequence ID" value="SEG82827"/>
        <property type="gene ID" value="SAMN04489712_11591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="92" mass="9752" checksum="92577EA2BF609CA4" modified="2017-01-18" version="1">MGYHENGDLTGYGAVADRLTREFAGVHDSATVTRYVAAARYGARDVTGSAAPDLVERIARKHLRVLAAVAAEKRRQAAPGLAAPQSTPEHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDY9</accession>
    <name>A0A1H6DDY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="9" type="ORF">SAMN04489712_115113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82953">
        <property type="protein sequence ID" value="SEG82953"/>
        <property type="gene ID" value="SAMN04489712_115113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG82953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="15982" checksum="670848F78E8AEE14" modified="2017-01-18" version="1">MKLILTQEVTGLGEPGDVVEVKDGYGRNYLVPRGLAIRWTRGGQREVDSIKKARSAREIATLEQAREVADRLRALKVVLRTRAGNGGRLFGSVTAADIVGAVKEAGGPDLDRRRVEIRNPIKTVGAHQVAVRLHPEVGTTVEVNVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIM2</accession>
    <name>A0A1H6DIM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_117117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85029">
        <property type="protein sequence ID" value="SEG85029"/>
        <property type="gene ID" value="SAMN04489712_117117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="93" mass="9547" checksum="2D6EE08713357018" modified="2017-01-18" version="1">MPIRRAAGRAPGRSGAGRGLSRGALASRTGHRALTCGCSPGPAGRDPVDRLDAQEGVQEGVPFGPGRGDRGSPSPSGYGSFRKRMVDSPQMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMM3</accession>
    <name>A0A1H6DMM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86391">
        <property type="protein sequence ID" value="SEG86391"/>
        <property type="gene ID" value="SAMN04489712_11970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="216" mass="23446" checksum="9AD1BA1E4E6F6DB1" modified="2017-01-18" version="1">MKRGRHAAVIGCGISGLTAAAVSARCFERVTVVERNVLPEGPGFRSEVPQSRHLHSLMGARQRALDELLPGFTEELYEAGAVPLRTTYDHLWLSPAGWCSRFHPPSHVVPSATREPIEWIVRRRVAQIPQVSLREGRQVRDLTVDSGRTRVTGVRASAGGSEEEIPADLVVDASGRRSRIPQWLAAMTAQALGTLLAERGGDVEDCAVISTGPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNJ0</accession>
    <name>A0A1H6DNJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-(Hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86256">
        <property type="protein sequence ID" value="SEG86256"/>
        <property type="gene ID" value="SAMN04489712_11934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="358" mass="36910" checksum="9A64BA377336B84E" modified="2017-01-18" version="1">MRALVWDGTGLYVDSTIEVRSPGPGEVAVDIAMAGLCHSDISPMEGRIPQPTPTILGHEAVGVIAAAGPGADVPVGQRVVLTVLRRCGECRHCREGRPNLCPASGLPVASPFSRDGDIVHQFVRLGAFAERIVVSQEQVIAMPAEIPDPVAAMLGCATVTAFGAVEDRARLRAGESVLVTGAGGIGLNTVLAARAAGAGRIVVVDRNPAKEQIARTCGATDFIIPSDPSQIAPAVQALVPGGVDAAFECAGHTGLLDAAIKSLAGGGRVVVLGLPPTGATLDLGVRDLFHDKSLLGCRMGSVDPHRKLPDLAERVLRGELDLTPLVSAVVPMEGAAQLVDDLRNGRIDRGFLRVGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPC5</accession>
    <name>A0A1H6DPC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86496">
        <property type="protein sequence ID" value="SEG86496"/>
        <property type="gene ID" value="SAMN04489712_11996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="726" mass="76989" checksum="1F4BF0A8A5504D9C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPD5</accession>
    <name>A0A1H6DPD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87227">
        <property type="protein sequence ID" value="SEG87227"/>
        <property type="gene ID" value="SAMN04489712_12093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="149" mass="16544" checksum="0F7DA0456633796F" modified="2017-01-18" version="1">MPINRCELFEILEDLGLPQEDYVVAGSAPLLVHGLRESINDVDVVARGAAWAAAAARGRVESAPYDRVRAVFLHGGEVEVLDGWFPETLGWKVDRLIDEADVVDGFRFLSVERTLEWKELLGRDKDDADLRSARRDGETPAGRGRSGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRB6</accession>
    <name>A0A1H6DRB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87256">
        <property type="protein sequence ID" value="SEG87256"/>
        <property type="gene ID" value="SAMN04489712_12098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="27955" checksum="26CFE1D8697DD21A" modified="2017-01-18" version="1">MSHGYSPRWRKFTIAVLRPLLFALLKRDWRGRRNVPAEGGMIVAANHLSWTDPLALAHFVYESGRYPVYLAKSSLFGNRFVGPVLRGTGQIPVYRDRSDARLALKAAEEALRAGECLMFYPEGTCTRDPRLWPMTGQTGVARLAITTGAKVLPVAHWGAHELWPYGTKRFRPFPRKTMHVIAGEPIDLSRYADRPMTAAVLHEATGEIMRAIAGLLGELRGEEPPKELYDHKKAIAERRRRDERGAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRG3</accession>
    <name>A0A1H6DRG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, DHA1 family, arabinose polymer transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87881">
        <property type="protein sequence ID" value="SEG87881"/>
        <property type="gene ID" value="SAMN04489712_12125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG87881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="402" mass="40557" checksum="7D4EE740AB157129" modified="2017-01-18" version="1">MPLALVALAIGAFGIGTTEFVIMGLLPEVAGDFGVSIPTAGLLVTGYALGVVFGAPLMTVVGAETPRKRMLMLLMGLFTVGNLISALAPAFAVMLLGRVVASLAHGAFFGIGSVVAAGLVAPGKKAGAIAMMFTGLTVANVVGVPLGTFVGQSAGWRVTFGIVAALGVIGLAGIAMLVPRTPKPEGVHLRQELAAFKNAQVLLAMAMTVLGFGGVFAAITYIAPMMTHVAGFADGSVTWLLVLFGLGMVGGNLVGGRFADRALMPMLYVSLGALAVVLALFTLTAHHKILAAATITLIGALGFATVPPLQKRIIDQAHRAPTLASAVNIGAFNLGNALSAWLGGLVIAAGLGYTAPNWVGAALAAAALLLAFLSAALERRDNAPNTAVAASAPAEQQPVGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSG3</accession>
    <name>A0A1H6DSG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88004">
        <property type="protein sequence ID" value="SEG88004"/>
        <property type="gene ID" value="SAMN04489712_12156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="14146" checksum="B175D2631D2E1BB8" modified="2017-01-18" version="1">MTSPGGAPRTGGTPGEAPRQPVRAYVMTRGRSQPSRNTLRPETLLIVTDPDRRPPPSATREERAFLDICRGLLSLAEAAQALHQPISVAAVLASDLIDAGHLTVRARPAAQPASPSSPDHHLLRALLDGLQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT19</accession>
    <name>A0A1H6DT19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">K+-transporting ATPase, KdpF subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87893">
        <property type="protein sequence ID" value="SEG87893"/>
        <property type="gene ID" value="SAMN04489712_12128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="29" mass="3175" checksum="60872A7940F01380" modified="2017-01-18" version="1">MTVENVVGLVLAVLLTVFLVAALLFPERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU43</accession>
    <name>A0A1H6DU43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88564">
        <property type="protein sequence ID" value="SEG88564"/>
        <property type="gene ID" value="SAMN04489712_12232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="26092" checksum="ED02EC0DFE7903B9" modified="2017-01-18" version="1">MEIKSKKVAVFGGASGMGRATAEAFAARGADVAVLDRPESGGEAVAKALGASFHTCDITDFEGTETALNEAVEALGGLHVTVTTAGGGIAKRTLGKSGPHDLDSFRQVLDLNVVATFNISRLAAAHMSANEPEDDERGVIINTSSIAAFEGQIGQVAYTAAKAGIAGMCLTMARDLGSLGIRVLAIAPSLFATGATAAIPDEMARSLTKDAAFPRRMGRPEEYAKLALAIVDNQMLNGQCLRLDAGQRFAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU63</accession>
    <name>A0A1H6DU63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-terminal half of MaoC dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88584">
        <property type="protein sequence ID" value="SEG88584"/>
        <property type="gene ID" value="SAMN04489712_12237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="1">
        <location>
            <begin position="53"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="49699" checksum="137B8496D5E7F88C" modified="2017-01-18" version="1">MLPRTKKLILFPMKMTDMPEDSGIEERFGVLTEEAIERSRRRLGVPQPQRNPPHNYEVTWDAVRHFAYGYGDDNPLYCDPAHGAATRWGRLIAPPTFLYTMGEDAAPEPDPQTKALLKGDPFAGLGSYQAVMEFEWWRPLELGDRCRMLQAQVGVQPKPSRFGGRTVHVTHDFLYTNGAGQMHAVRRGTWINAERHTSKKRAKEKLVQEPYTSERLAQIDALYAAETRRGAEPRFWEDVQAGDELQPRVKGPLTTTDVVVWHLGWGMQLTPPGSFRLAHRVRTKAPGLYPPNALNVPDTVQRLHWEPQRAQELGLPNSYDYGGMRETWLCHIITDWMGDDGWLWKLRCEHRKFNYIGDTTWVRGRVTGKRREGGRNEVHLEVWCENQRGETTTPGTAVVLLPTRERPRVELPESPAPDLDGMVAHELRRFDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUX9</accession>
    <name>A0A1H6DUX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator, regulatory protein PadR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89060">
        <property type="protein sequence ID" value="SEG89060"/>
        <property type="gene ID" value="SAMN04489712_12312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="95" mass="10357" checksum="A85796F6DF9CD940" modified="2017-01-18" version="1">MLAALVRRESYGYELAQSLDAAGLGPIRGGTLYPVLLRLQRTGMVTAQWREGEAGPARKYYRITESGGEVLRRTAADWESFAGGVSAILREVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY68</accession>
    <name>A0A1H6DY68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90109">
        <property type="protein sequence ID" value="SEG90109"/>
        <property type="gene ID" value="SAMN04489712_12541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="14670" checksum="D2EBD89148B5B272" modified="2017-01-18" version="1">MSVTLDHIIIPARDKKTSAEFLARLLGVEVGAPMGPFVPVTTGNGVTLDYMDSEDFRWHHCAFLVSEEEFDAIFARIKEAAIPYQANPDGSGAGEINRRDGGRGVYFDDPNGHRMEVLTVPYGGWKQAKTERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZC7</accession>
    <name>A0A1H6DZC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90541">
        <property type="protein sequence ID" value="SEG90541"/>
        <property type="gene ID" value="SAMN04489712_12667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG90541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="381" mass="41958" checksum="6932074C7923E323" modified="2017-01-18" version="1">MRRNVYDDDHEVFRQAVREFVRREVLPHVDDWAVDKGLPRSFWLAAGRQGLLGLEIPAGYGGSEAGDFRFNAVLMEELAAVNMALPSCVGIHADIVPPYLVHLASPEVRSEWLPRLSTGEAVAAMAMTEPGAGSDLGAVATSAVPDGDHYRINGSKTFITNGHTADLIVVAARTTPDAGPKGLTLFAVPADTPGFGRGRKLDKVGQPESDTAELFFEDVRVPKSYMIGELDRGFMHMMTWLPQERLSAAVTNLAHARQMVDETLRYATERTAFGRPVGAFQANKFLFADIVTRLDVTQAYVDQCVLAHTRGELTPVDAAKAKWWTAQVQNEVLDHCLQLHGGAGYMNEYRIARAWRDARVTRIWAGSNEIMKEIIGRDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZZ1</accession>
    <name>A0A1H6DZZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">MEP cytidylyltransferase</fullName>
            <shortName evidence="3">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ispD</name>
        <name evidence="4" type="ORF">SAMN04489712_12759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90857">
        <property type="protein sequence ID" value="SEG90857"/>
        <property type="gene ID" value="SAMN04489712_12759"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 3 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG90857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="242" mass="25467" checksum="3651BCAD9476F07D" modified="2017-01-18" version="1">MRTVAVVLAGGTGRRIGSATPKQLLEVGGRPILAYAIGAFDGHRGVDEVLVVMARGHVPQATRIVSEHGYGKVSRVVEGGDTRAESTVAALTALAAEPDDTRLLLHDAARPFVTAEVIDRCLAALESHQAVAVGVATPDTVVAVRDGLVAAMPPRDSLCRFQTPQCFRIGTLRKAYEAALADPAFTATDDCGVVHRYLPDVPIRVVEGDERNLKVTHPLDLVVAEHLAGLAGPGLPPDPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0X6</accession>
    <name>A0A1H6E0X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine dioxygenase type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91187">
        <property type="protein sequence ID" value="SEG91187"/>
        <property type="gene ID" value="SAMN04489712_12857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="16893" checksum="0315BDE3A2E1577E" modified="2017-01-18" version="1">MTLSTSPAPAGTRPAEIARSLAAAPQDWIERVRLRTEERWYERLHRDDDVEIWLISWMPGQSTGLHDHGDSRGAFAVALGSLDEYDLTARRTLATGQSREFGTGYIHEVINASDAPAVSVHVYSPPLTVMNRYDLTGSGELVQLAAERSDQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1G9</accession>
    <name>A0A1H6E1G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate or tyrosine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91450">
        <property type="protein sequence ID" value="SEG91450"/>
        <property type="gene ID" value="SAMN04489712_12921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="455" mass="47145" checksum="5FDE5AA93646253F" modified="2017-01-18" version="1">MEELSRLFRLAADHAADYRRSLPDRPVGVPVDQEALVEAFSGPLPAAPCPPERVLAELLAAAEPGLVASAGPRYFGFVVGGALPAATAADILAAGWDQFATNAVTSPAAIAAEAAAGAWLKELLGIPSSASAGFVTGCQAANTVGLAAARHQVLAEVGWDVERRGLLGAPPIRVIAGEERHATIDRSLRLLGLGVDVVEPVPVGPNGAIDLEALREVLRAGPQGPAIVCLQAGNVNTGACDRLGEACELVHRHGGWVHVDGAFGLWAAAGPATRHLVDGLELADSWACDGHKWLNLPYDSAFAFCARPEVHAAAMSYAAAYLVGSGGAPVGADLTAESSRRARGFAVWAGLRELGRDGVAALVERCCALARRFADGLTAAGFEVANEVVLNQVLVDFGDDARTDRVVAAVQADGTCWAGGTTWRGRRLMRISVSNATTTEADVDRSIAAITRLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1I3</accession>
    <name>A0A1H6E1I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91498">
        <property type="protein sequence ID" value="SEG91498"/>
        <property type="gene ID" value="SAMN04489712_12937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="28594" checksum="63DF57E6B79265CA" modified="2017-01-18" version="1">MTAAPGPLQVTDLTVRFAGLVALDAVSFTVTPGTIHAVIGPNGAGKSTCFNVLSGVYKATSGSVRFGDTELTGLPTHRITALGVARTFQNIALSPHLSVADNLMLGRHRLTRAGFVSTGLRLPSARREAAAHSARVAEIAAFVGLTDRLPVPVGLLPYGVQKRVELARALCMEPSLLLLDEPVAGMNGGERREMAALISAVRQDLGISILLVEHDMGMVMRLADAVTVLDFGRCIADGAPADVQRDPEVVRAYLGDSGTTSPQSCAPFKEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3V0</accession>
    <name>A0A1H6E3V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91923">
        <property type="protein sequence ID" value="SEG91923"/>
        <property type="gene ID" value="SAMN04489712_13130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="29789" checksum="E4B5AE9174C520B3" modified="2017-01-18" version="1">MTALGAAAVQAAAAPLDPAANAAAGSAAIAAAAGAGAGLVVLPELFATGYVLDRTALAERAENTAAPGTCLTAWSAAAARHGVTVVAGFAERDGDRLFNSAAVIDRSGAIAGVYRKLHLFGAERDVFDPGDRGLPVFTVDGIRLGVLICYDLRFPEAMRILALRGAHVVAVPTAWVRGFDHARHGDRVPQATGALVQANLNQVAVVCADQWGEQPPHTFLGRSLVADPYGLPAAGPLGAEGDGTALALIDLDEITRARERAVGSPVRDRRTDVYAADLGYAGDPPDGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E485</accession>
    <name>A0A1H6E485_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92397">
        <property type="protein sequence ID" value="SEG92397"/>
        <property type="gene ID" value="SAMN04489712_13341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="455" mass="46247" checksum="480CF2ACB20EF1C6" modified="2017-01-18" version="1">MGFRSRLGRSARAAGTGARRAGGAVRRVTHANGAGRSGLGGLIETAGVNGAGDALVAVALAGTLFFGLDVNEARGQVALYLLVTMAPFALVAPLIGPALDRMRHARRYAIAGTMLARGLLCWGMAGAVTHGDQVTLLPAAFGVLVLSKAFGVLRSAVTPRLLPDQITLVTANARASFAGLIAASTAAVAGAGLAVAAGPDWVLRIATVVFVLGAVLAMRLPAHVDVPEPAPATATGPGAPPAGRRWRTLPRVGPVVAEAMQANAALRAFSGFLILYLAFLLRERRFEPVSHTVALGLLAACAGAGGLAGTGLGAWTKARAPHLMVFATLTVAAASAAAAAVFFGLWAALAVAFVGGFGQSLGKLAMDAVVQREIGEEVRSSTFAVSETLHQLVWVLGGLAGLGLSIVADGRVALAGVAAVLGLALAALLAGRARRSARRRTSLRKNPPEPRREPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4N5</accession>
    <name>A0A1H6E4N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92738">
        <property type="protein sequence ID" value="SEG92738"/>
        <property type="gene ID" value="SAMN04489712_13516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="86"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="322" mass="34989" checksum="71B2C77EA843BCE4" modified="2017-01-18" version="1">MPVPTRRRIPQLDPDARALRDAFEKQGRRPMREIGVEAMRKVLEDVPHPSGLPEMATAEEHLLNGPHGPFRLTVHSPSAAGELPGIVYFHGGGMVLGSNHSFEPLARNMAHHTGARVVAVEYHLAPEFPPPAQLDDAWFATRWVAEHAGELGILPDRLCVAGDSAGGTLAAGVCLMARDRGGPRIFCQILVYPGVDRDLGAASISEFSDAFGLGRDDVLFLHEVARAGGPEPTSPYQVPAYADDLTGLPPAIIAVGELDPIRDWAERYAERLRDAGVQTTITRYPGAYHGFLLRMDFVARGRLAMAEIAGILRAKFAHPLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E588</accession>
    <name>A0A1H6E588_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron(III) transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92797">
        <property type="protein sequence ID" value="SEG92797"/>
        <property type="gene ID" value="SAMN04489712_13533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="372"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="574" mass="61560" checksum="35D5B0402C5CF679" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5G6</accession>
    <name>A0A1H6E5G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_13621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92940">
        <property type="protein sequence ID" value="SEG92940"/>
        <property type="gene ID" value="SAMN04489712_13621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG92940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="29241" checksum="BC9DF3FD2BDD84BA" modified="2017-01-18" version="1">MSVVAQAVVGTIVTGSVYGLVGVGFALLFRASKVLSFAQGGFMLLGAFVFYSLVTGGRPFLPAVLVTMITVAAFSAVVYVLIFARVAAREAFATSVATIGLAGVLQAAVGIRYGTAPLSLPDVVSTRAFRILGAVVQVADIVAVVMAVTVVAALVLILRHSQIGLRMNAVADNATLAVHLGISSARIATVAWALAGGTAALAGIAFSLRSAVDPVGVANIGLLAFPAIILGGLGSVGGALAGGLLLAGIQNAVRIGIGAGWVDFVSFALMLGFLFFRPSGLFGKAEVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E821</accession>
    <name>A0A1H6E821_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="8">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_1417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93847">
        <property type="protein sequence ID" value="SEG93847"/>
        <property type="gene ID" value="SAMN04489712_1417"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG93847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="130" mass="15147" checksum="E33E9D12B6656E9A" modified="2017-01-18" version="1">MYEIAKSFGFSASHRLERLPEGHKCRRLHGHNYTVEIRLIAEELDEQDFVADFGELDRVGEWLRVAFDHRHLNDVLTVDPTCERLAEVIYEWCVRHLPSALTPMLHAVRVSESPSSWAEYRRAAETETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAM1</accession>
    <name>A0A1H6EAM1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000051">
        <property type="protein sequence ID" value="SEG94787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94787">
        <property type="protein sequence ID" value="SEG94787"/>
        <property type="gene ID" value="SAMN04489712_1517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG94787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12928" checksum="193F99AC4DEAC11B" modified="2017-01-18" version="1">MATVTLTADNFDTTTQADGIVLVDFWAAWCGPCRRFAPVFESASERHPDITFAKVDTDAEIELAERFGISSIPTLMAVRDGVIVFAEPGALPEPVLENVIEQVRGLDMEDVRKRMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBH7</accession>
    <name>A0A1H6EBH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000049">
        <property type="protein sequence ID" value="SEG94611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94611">
        <property type="protein sequence ID" value="SEG94611"/>
        <property type="gene ID" value="SAMN04489712_1495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="88"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="142"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG94611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23505" checksum="29B2A65D1DC86EBD" modified="2017-01-18" version="1">MRRCRVKDVMTHDVVAIGAVTPYSEVLKAMAAHGVGALPVIDERLRVIGIITESDLLFEEHPAPVSPDEPWRRHEHAKAEATTAMGLMTSPVIAVTEEAPAARAARVLSEYGINQVPVTEPDGTLVGIVARSDLLRVFLRPDQEIHDEVTREALAHVLRQDSDEVTVTVCDGVVGLHGRVRAAGLVPVAVRLALSVEGVVDVVAELDYEPDDTASPPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECL0</accession>
    <name>A0A1H6ECL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94535">
        <property type="protein sequence ID" value="SEG94535"/>
        <property type="gene ID" value="SAMN04489712_14816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="43"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="26937" checksum="B01D8E8936164D8B" modified="2017-01-18" version="1">MSNEAIKALIPQLDAVDDSPGAAELRARSYELLHAAPGALVIDAGCGAGRAVAELADQGVRVMGIDVNDQMIALARERWPYGEFRVGDVYALPLGDGEVAGYRADKVIHTLADPGQALAEARRVLASGGRIVLCGQDWDTLVIDSTDPELTRTIVRKRADQVASPRAARRYRNLLLDAGFRDVTVEVHTGVFTDDSFLPVLTRLAEFCCEHGAITRAQADTWIADQRERARADRLFAAVPIFMAAATNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECM6</accession>
    <name>A0A1H6ECM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine phosphatase RsbU, regulator of sigma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000051">
        <property type="protein sequence ID" value="SEG94769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94769">
        <property type="protein sequence ID" value="SEG94769"/>
        <property type="gene ID" value="SAMN04489712_1512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="172"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="325"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="492"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG94769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="719" mass="75515" checksum="9AAF2453B4104A70" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECP7</accession>
    <name>A0A1H6ECP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_15022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94726">
        <property type="protein sequence ID" value="SEG94726"/>
        <property type="gene ID" value="SAMN04489712_15022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="310" mass="35394" checksum="6FC4E2560DD2B660" modified="2017-01-18" version="1">MTHPVRLKVLLRERHWQTHRTFLAEYDKAARKVDPSLVGKGPSRAQLHRWTSGEVKGLPYPDHCRVLEKMFPGWTAEQLFERVDDDQAPPMPEVSPTPTPTETSSQAEAGDVQPDRWGAELSGNIIELSMRCDIDIDPDGWSRVTYQHELLNLSDRPLTRLAREVWFENTRELLSIDPAPDSERRVMIQRIHDTANLAKFACQMSPPLPPGESAIIGYRVEGGQFLADHYWRQSIPRHVRHLTISVRHRGAGKLLRCWAIEEHPDGSENSADAGLVWDYEGDDVVITLNRDHLRPNQAVTVRWDVPHEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SRQ7</accession>
    <name>A0A1H5SRQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52668">
        <property type="protein sequence ID" value="SEF52668"/>
        <property type="gene ID" value="SAMN04489712_101315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015057">
        <property type="entry name" value="Rv2632c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038070">
        <property type="entry name" value="Rv2632c-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08962">
        <property type="entry name" value="DUF1876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143212">
        <property type="entry name" value="SSF143212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF52668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="88" mass="9848" checksum="CCA288254A17BAB1" modified="2017-01-18" version="1">MNENKSWRLTVDIVEQERYTEAEARLETPSGTLTGRGVARRNPRDADVPSIGDELAVSRALSELSHGLLDAAAREISQVEHRRVRLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T8D3</accession>
    <name>A0A1H5T8D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59024">
        <property type="protein sequence ID" value="SEF59024"/>
        <property type="gene ID" value="SAMN04489712_101521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="206"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="381"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF59024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="463" mass="48383" checksum="B59207F6D47CDB85" modified="2017-01-18" version="1">MRGILGWGGYLPHRRLDRSAIRPVAGTGGGAGTRTVASYDEDTTTMAVAAARHALRGAPARPRALWFATTEPAYLDKSNATAVHAALRLDRTVAAYDASGSVHSAMGALRAGLDGAGPALVVASDLRTGLPGGPDEAAGGDGAAALLVGSDHDAPVLAEPLAWTSLTEEFLDRWRTPGAPASRLWEERFGETRYTGLGLETLKLALDEAGTAPSDVSTLIVAGLHERAAKAVAARSGVPADRVADRLGAQAGNVGAAQPALLLADALERARPGQTVVLVTLSDGADAVVFRTTGALAAHRPGRTVAAQLASGVPVSYGTYLAWRGLLPVEPPRRPEPARPSAPAAGRNREWKFGFVGSRGDDGTVRLPPSPLDDARHPMADATGTIVTFTVDRLAYSPSPPVVFAVVDFDGGGRLPVELTDVDEGEVRIGGRVEMTFRRLFTAEGVHNYFWKARPVRDAEESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5THD2</accession>
    <name>A0A1H5THD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62174">
        <property type="protein sequence ID" value="SEF62174"/>
        <property type="gene ID" value="SAMN04489712_101619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF62174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="17590" checksum="4888CE65EF56BAFB" modified="2017-01-18" version="1">MTEAAGSEIVRRWREVLTCYSRVSCALDRALQDAHGIGMSEFEALERLAETADDKIKMNRLGADMYLSQSALSRTVARLERAGLVERDMCPQDRRAVFVSLTDTGRELYTRARTTQRAVLAEHMVDDRGASPDGQDSGACDSGREDEADSRTSGGLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TID1</accession>
    <name>A0A1H5TID1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62530">
        <property type="protein sequence ID" value="SEF62530"/>
        <property type="gene ID" value="SAMN04489712_101631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF62530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="311" mass="35116" checksum="54A044135CFE266B" modified="2017-01-18" version="1">MTQQTEGPGEILDDVLRTGPFDRALHLAIQARGLSLERIHARLRHRGVHVSVASLSYWQRGRCRPERSQSLRAVEALEEILGLPPNALIALLGPRRPRGRWLGHVPGALTYGDLCPVYPGLRDLLGEMRNPVDGQLETLSHHEVYTVGPDHRERSARSRIVFRARRDGVDRHVAIHHCEGGPPPDGFSSEMCRVGRVRVGAADGLTAVELLFDHPLAAGETYVVEYEFSCGGGQPEARRYVRGFRFPTREYLLQVRFAAEATPRRCFRIWQPNIGAVCTDRQELRLNKWDSVHLLEHGVQPGLYGIRWEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TK51</accession>
    <name>A0A1H5TK51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannose-1-phosphate guanylyltransferase / phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63185">
        <property type="protein sequence ID" value="SEF63185"/>
        <property type="gene ID" value="SAMN04489712_101652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="378"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="528"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="5">
        <location>
            <begin position="636"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF63185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="827" mass="89396" checksum="51C98B24E77DC24E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TPY7</accession>
    <name>A0A1H5TPY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_101704</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64854">
        <property type="protein sequence ID" value="SEF64854"/>
        <property type="gene ID" value="SAMN04489712_101704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="173"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="294"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEF64854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="368" mass="41365" checksum="1611F28EA9B94659" modified="2017-01-18" version="1">MAQIVKRAYKYRFYPTPGQAEELARTFGCVRLVYNKALEERTRAYTLEGRRVSYVESSAALTQWKRADELAFLNEVSSVPLQQALRHLQSAFANFFARRAKYPTFKSRKKSRASAEYTRSAFRWRDGRLTLAKMSDPLDIVWSRPLPEGAEPSTVTVSQDAAGRWFVSLLVEEKIAPLDPTGSLVGVDAGITSLVTLSTGEKVTNPRHERADRRKLAKAQQALARKAKGSANRAKAQLKVARVYARIADRRRDHLHKLTTRLVRENQTVVIEDLTVRNLVKNGSLARAISDASWRELRSMLEYKAAWYGRELLVIDRWFPSSKLCSACGALQESMPLAVREWACACGAAHDRDVNAAKNILAAGLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TXS0</accession>
    <name>A0A1H5TXS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crotonobetainyl-CoA:carnitine CoA-transferase CaiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67625">
        <property type="protein sequence ID" value="SEF67625"/>
        <property type="gene ID" value="SAMN04489712_101787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF67625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="42571" checksum="35B90FF218C6983C" modified="2017-01-18" version="1">MTATPYHGLRVVEIADDPGGEYTGKLLAGSGADVIKVEPPSGAAGRRIGPFAGDRTDPEASLSFRWYNAGKRSVTIDDAEDAGRAALAELIAGADVLLTSLPPAQAAARGLVPAELAARHPRLIVVAVTPFGLDGPWSAYRGGDLVGLAAGGMLHSCGYDDHSIPPIRPGGDHAYTTAASFAHTGLLLALLERRRTGKGQVVDVSVHAACAVSGELSNPFWFYPKAIVKRQTCRHAQPAPTQPALFRCGDDRYVYFALILADQKPWRALVEWMDDMGLAADLTDPAYDDLAHRQANFAHVQELVEVFFLLMDAETAYHEGQRRGLPIGVSRAPEELFDDEHLRAREFFVEVEEEEGARPVPHPGSPYRFSSFDLPGPRRAPRLGEHTAEVLEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U3Y9</accession>
    <name>A0A1H5U3Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68997">
        <property type="protein sequence ID" value="SEF68997"/>
        <property type="gene ID" value="SAMN04489712_101836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="372"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEF68997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="524" mass="55741" checksum="FB2D7528D7916585" modified="2017-01-18" version="1"> </sequence>
</entry>
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    <accession>A0A1H5V5I6</accession>
    <name>A0A1H5V5I6_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Short chain enoyl-CoA hydratase /Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102170</name>
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                <person name="Submissions S."/>
            </authorList>
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    </dbReference>
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        <source>
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            <dbReference type="EMBL" id="SEF82456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="270" mass="28810" checksum="7CA997A208766E2E" modified="2017-01-18" version="1">MAEGGHLLLDRRDGVLVITLNRPERLNAVSAAVSEEMVDVLNGLMRDPRTHVVVLTGAGRGFCSGMDIRDDGPGTAEPDAEGRAQRLYRGIAGGGEVTARLREIPQPVIAALHGPVAGMGVSWALACDLRVADPTTRFVLPFTDLGLSGGDCGLSWLLPRLVGPAKAADLLYRARRLRAEEARELGLITEMAEEGGDLAAALALAGELLRRSPYGLRRTKELLNASLDAPGLRQQLVAETGIQTLAFFTEDLAEGMTATLAGRPPEFRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W0W5</accession>
    <name>A0A1H5W0W5_9ACTN</name>
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        <submittedName>
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        <name evidence="2" type="ORF">SAMN04489712_102549</name>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93152">
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        <property type="gene ID" value="SAMN04489712_102549"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS_2"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEF93152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="461" mass="46822" checksum="92BAB80C65D84F37" modified="2017-01-18" version="1">MSAGPAPGRVDGAVPPLGRGRLLGYGVGSVGTGVFSAVPGLLLLYYLTDVLGVSAAIAGVVLVVPKAWDVILNPIVGAASDREAVRTGRRIRLLLAGALTLPVLFAAMFAAPGSSPAPAAAWVAVAFLLAASAFACFQVPYVALPAEISSRPDQRSRAMTWRIVALTLGILVAGGAAPALVELAGGGRAGYALMGVVIGLVIAAALLTSVVSTRWIASRAGPRPLGLVAALRTAWGNRPFFVLLGAAVIQTLAVAVMLAGAPYAATYLLDDYGLTSAMFVCLVGPSIPAVPLWNRLARRHGPIPCYVVAVAVFAAGTVALYPALDAGAALPVLALCGLLGVCYAAIQLLSFSLLPESVHADSGRTGHAQAGAFTGVWTAAETGALAIGPGVFALVLALTSYRAADFDEPVAQPGSALTGLTAGFTLLPAALLLLSIPLLLSYRRLAARQYVTHDAEGEHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X794</accession>
    <name>A0A1H5X794_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_103120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07619">
        <property type="protein sequence ID" value="SEG07619"/>
        <property type="gene ID" value="SAMN04489712_103120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
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        <location>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="SEG07619.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1047" mass="110506" checksum="C6A8CABD6A65A90A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XNN7</accession>
    <name>A0A1H5XNN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3" key="1">
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                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG12970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="28695" checksum="97E755F13AE8F8BB" modified="2017-01-18" version="1">MPEVTARGLRFHVQELGPPEPAGDAPVVVFVHGLAIDNLTSFLYTLAGPLARAGAHCVLYDLRGHGLSERPATGYTAADGVADLFGVLDALGHRRPVHLVANSFGGVIALNAALARPGRVAGLVMIEAYGPAWHTGDWNEHMLNTLGKSALTLEYERTAERLLEIGWRRQGRQTATAAALLNGTSLLADLAAADPVPPPGLTGLACPVLAVYGEHSEVAGAGRLLLRHAPDCSLHQMAGYAHTVLTDGTAELLGVMLPWLADRAGLRVPVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XPN9</accession>
    <name>A0A1H5XPN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13711">
        <property type="protein sequence ID" value="SEG13711"/>
        <property type="gene ID" value="SAMN04489712_103351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG13711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="42008" checksum="1CF82FCF159AB3F9" modified="2017-01-18" version="1">MTGDRTYDLVLFGATGYTGGLTAEYLARHAPPHTRWALAGRNRAKLEAVRERLAAIDPACGDLPLLHADATDTASLQAVAECAKVVITTVGPYIRYGEPLVAACARAGTDYVDLTGEPTFVDLMYLRHHEEAVRSGARIVHACGFDSIPHDLGAYFTVKQLPEGSPLHVEGFVRFSGDISGGTLHSALEVLTDLPGMVRAERERRRIEPRPAGRRIRISRSPVPRTRVGGGWTLPMPTIDPQIVTRSAAALDRYGPDFSYGHYVAVRRLAAAAGMAAGSAAALVMAQTPPTRSLLLRLRDPGSGPTPEQRAKARFSVTFTGRVTGGAHKGQQVVTEVAGGDPGYGETAKMLAESALCLAHDDLPQTSGQVTTAVAMGDALIDRLVRAGITFRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XPR4</accession>
    <name>A0A1H5XPR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13751">
        <property type="protein sequence ID" value="SEG13751"/>
        <property type="gene ID" value="SAMN04489712_103353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG13751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="23734" checksum="B11EF49FDD2F3C3E" modified="2017-01-18" version="1">MVPPVRVVLVDDHEMILAGLQAMLAGFAGRVRVVGQAGTSREAVRLVTALQPDVVLLDVRLGPESGLDLCRDLTTRSPDTRVVFLSVYDDEQYVFEALRAGAGGYLLKRVDGLELVRRLEEVAQGETVVDPTLAGRMAASAARLNRGEFWPGADRGLTQRESEVLSLLVAGLSNRAMAARLVLSEETVKSHLRALYRKLEVTDRSAAIAVALREGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XRX4</accession>
    <name>A0A1H5XRX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14494">
        <property type="protein sequence ID" value="SEG14494"/>
        <property type="gene ID" value="SAMN04489712_103382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG14494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="6618" checksum="58ECC6FFE9C91D60" modified="2017-01-18" version="1">MRVRIGCALFALTGVFGVLAVLTSQPSTRAAFVVVGVVVLAVLAVLLVLASMGLAVPAVAVTLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XVT2</accession>
    <name>A0A1H5XVT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15772">
        <property type="protein sequence ID" value="SEG15772"/>
        <property type="gene ID" value="SAMN04489712_103430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="51"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG15772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="29866" checksum="74DAF9F52189B0C2" modified="2017-01-18" version="1">MTSAPVDFESIKKTQRAGWETGDYPRVGNTLQIIAELLVEAADVRAGQRVLDVACGQGNAALAAARRFAEATGADYAVNLLEQGRERAAVEHLPVTFVEGDAEQLPFPDGSFDLTVSTVGVMFAPDHQRAADELVRVTAPGGRIALASWTPTGMIGHLFKTVGRWAPPPAGVRPPVLWGTPEHLSALFGERVEWIALNKREYVFRYHSPQHFSEWFRRFYGPITRLSGTLSEEDLERFSEDLAEVARQFNRTDDGTVAGAAEYLEAVGVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y1B2</accession>
    <name>A0A1H5Y1B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17869">
        <property type="protein sequence ID" value="SEG17869"/>
        <property type="gene ID" value="SAMN04489712_103512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="14503" checksum="254992979546EC27" modified="2017-01-18" version="1">MAKMPGKSGVGGYELRREVLAVPATVGLLRDLTQVHLAKWGASERFADNVRLVVSELVTNSVAACPGRAIVFVMYAVVGAVVVEVRDPSERAPVHRPAGPGDEGGRGLQIVGALAESWGTRWPPGGGKVVWAKMTATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YGI2</accession>
    <name>A0A1H5YGI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cellulose binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_1041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23158">
        <property type="protein sequence ID" value="SEG23158"/>
        <property type="gene ID" value="SAMN04489712_1041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.870.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023309">
        <property type="entry name" value="Endo-1-4-beta-glucanase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027390">
        <property type="entry name" value="Endoglucanase_F_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000556">
        <property type="entry name" value="Glyco_hydro_48F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02011">
        <property type="entry name" value="Glyco_hydro_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00844">
        <property type="entry name" value="GLHYDRLASE48"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG23158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="940" mass="100912" checksum="047F7A77FC403AEC" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YIX7</accession>
    <name>A0A1H5YIX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24083">
        <property type="protein sequence ID" value="SEG24083"/>
        <property type="gene ID" value="SAMN04489712_10442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG24083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="71" mass="7737" checksum="19696C54EBA7A4F3" modified="2017-01-18" version="1">MKALPDLAPIIGTLLAYGGLCLLTGLTLGYLLGTTRRERRLTAPFRPRPGRHARPPAHRRVGRGHPAAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YM08</accession>
    <name>A0A1H5YM08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24537">
        <property type="protein sequence ID" value="SEG24537"/>
        <property type="gene ID" value="SAMN04489712_10462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG24537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="26076" checksum="1FC86578E5C60BAF" modified="2017-01-18" version="1">MTPRTDADELIEQPRIPLSRRRVLRAAVELADRDGLDALTMRRLAQEVGAEAMSLYHHVANKEAVLDGVVEVILGEITAAVDGVEAPSPEEDWQAALRARILAAREVFLRHRWAPQVLESRTNTSPAVIAYYDQVVAILRAGGFSFDLAHRALHVLGSRALGFTQELFQPGGAETADAEAAAMMEQMADQFPNIVGMLADAIHDDPDGTLGFCDDQFEFEFALDLILEGLERRRAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZU5</accession>
    <name>A0A1H5YZU5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rex</name>
        <name evidence="9" type="ORF">SAMN04489712_104262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29310">
        <property type="protein sequence ID" value="SEG29310"/>
        <property type="gene ID" value="SAMN04489712_104262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="8">
        <location>
            <begin position="87"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="98"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG29310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="26675" checksum="E21A48C0FD308968" modified="2017-01-18" version="1">MTRRHNRTRAERGIPEATVARLPVYLRALHSLQERGVATVSSEELATAAGVNSAKLRKDLSHLGSYGTRGVGYEVEYLVYQISRELGLTQDWVVAIIGVGNLGRALAGYGGFASRGFRVAALLDADESVVGERISGLTVRHIDDLESVVAEQGVSIAVLATPAAAAQSLCDRVVAAGVTSVLNFAPVVLSVPEGVDVRKVDLSIELQILAFHEQRKAGGPGEGGWAGELDGPGDRPRGEGPPGTKQYIEAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z4F4</accession>
    <name>A0A1H5Z4F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31393">
        <property type="protein sequence ID" value="SEG31393"/>
        <property type="gene ID" value="SAMN04489712_104355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG31393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="452" mass="49080" checksum="52A0F95ADAF86F8C" modified="2017-01-18" version="1">MAKILDRPDFARWAARARATGGCAQPIFLTGTVDHVHTGTGEVLHHYSTDTEPDGALPVACKTRRATRCPACAEVYRADTYQLIRAGLAGGKGVPETVTAHPAAFVTLTAPSFGPVHARRERSGGRVERCHPRRDAKPCPHGVVASCGARHDRDDPKLGEPLCPDCYDYAGSVLFNALAPELWRRFTLALRRYLAKCAGLTQKELRETLAVSFAKVAEYQRRGVVHFHAVIRFDGPAGPSTPPPGWADVQLLDDAVRHAAAAVSVTTPAAPGIPARSLTWGAQVDVRRITSSGALTQEAVAGYVAKYATKAAECVGTLDRRLRPTDDLDKLPITPHARRLIRECLRLGALEQFAELRLVQWAHMLGFRGHFSTKSRRYSTTLGALRAARIAYVRAQFPGWQPPDDQGPELITAIGEWRFHSQGLTRGEALVTAALTGKPLPPPASTDRRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZVU5</accession>
    <name>A0A1H5ZVU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40262">
        <property type="protein sequence ID" value="SEG40262"/>
        <property type="gene ID" value="SAMN04489712_10524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291969" evidence="2">
        <location>
            <begin position="28"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG40262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="344" mass="36820" checksum="E91576E4D7B712EA" modified="2017-01-18" version="1">MVGAAPLFAMALVVGAGPAGGVGVAAAATGAVHPSDSRRFALTAPSHALFQDRRLKDGTVMQSFGFDIANGRLFTAQLKSGPWSDENGDLTISRLDLAGNLLGHMHLEGFGHGTAIGVESSGDASYLWVEVDPTGFSARGTQLARFKFVDGVTLTNESPELTKYQPVPDVSGVTATIDPVNGRLAMRYKEDGWRIAVYDLADLKAHHYDDPVFDIAQPSLGGETFQGYALYGKYLYTYSGNPYGPGNPPPGNARLSTIDLETGRRVEGPTLTTAGSALTFREPEGMAIHRTVEGEVRLFFGMASGEPGKRRANLFYNNALIGEQDGMRRSGRARPRMPKRPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZX88</accession>
    <name>A0A1H5ZX88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-Methyltransferase involved in polyketide biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41069">
        <property type="protein sequence ID" value="SEG41069"/>
        <property type="gene ID" value="SAMN04489712_10563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG41069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="277" mass="30403" checksum="D5959AF30793C51A" modified="2017-01-18" version="1">MHDDEPAFSWTEAHKDLMAGIDASVPHSARIWNYWLGGKDHYPVDQEAGDAYVRVFPGILDIARGQRYFLARAVRYLAGEAGIDQFLDIGTGLPTVDNTHEVAQRVNPACRIVYVDNDPLVLVHARALLGGTSQGVTQYIDADARDPEAVLRQAAETLDLTRPVGLMMLGILGHVTDDEEARSIVRRLLESLPSGSHLVLADGTDTDPAFVEAQRYYNDGGAAPYELRSPERIARFFDGLEMVEPGVVTLPHWRPDMPPLDDGNAHVAEVCGVGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZYN2</accession>
    <name>A0A1H5ZYN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41569">
        <property type="protein sequence ID" value="SEG41569"/>
        <property type="gene ID" value="SAMN04489712_10586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="9"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="325"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="163"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG41569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="453" mass="47356" checksum="69A2732E0B1E573E" modified="2017-01-18" version="1">MAATRKPHYDVVVLGGGTAGELAARALAEAGRHVALVENRLVGGESPYFASIPSKSLLHSARRGETWETAIVRRDELTGELDDAPAVARLAQAGVTVLRGYGQVAEPGTVEVDGAAYGYGDLVVCTGGEPVVPGVEGLADAPIWTSDEALAVPDLPRRLVVLGGGRVGCELAQIYAAFGSQVAVVETAPGLLADEAAFTGEVLAGALRRMGVDLRLGTEPAKVERTRTGLRLWLSDGGTLDTDRVLVATGRRPRTEDLGLEALGVTVAPGEPLPVNETCRVPDAEGLWAAGEVTGVSTAHAAAYQARVVVDNVLGKRREADYRAIPRVLFTTPSVYAIGVSPRHAEKAGLDLLSAGYDLAATARGRVEDSGLGGLGGRIDSRMEGRVELYADRATGLLTGAAAVGPYAEEWMGEIALAIRAQVPLRVLADVVHAFPTYGEAVEVPLRELAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A0X3</accession>
    <name>A0A1H6A0X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42368">
        <property type="protein sequence ID" value="SEG42368"/>
        <property type="gene ID" value="SAMN04489712_105134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG42368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="113" mass="11799" checksum="002191D7BC69D104" modified="2017-01-18" version="1">MTTATHKQTKGTPVRGVPTGRGGRSQAAFEPGSWRRAAARSREHGATRLELPVVGTVKLPPRNQLAFIGGVGLLAMAGVIDWPVAAVIGLGHLLAGDRSDQAVHDFGEALEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1V1</accession>
    <name>A0A1H6A1V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_105137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42421">
        <property type="protein sequence ID" value="SEG42421"/>
        <property type="gene ID" value="SAMN04489712_105137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG42421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="34708" checksum="E5E59F0F84977EFC" modified="2017-01-18" version="1">MTDLAIAANGLRKSYRDKDGDKVVLDGIDLAVPEGTIFSLLGPNGAGKTTTVQILSTLIRADGGQVQIAGYDLNRQADDVRGMIGVTGQYSAVDKLLTGEENLLLMADLKHLPKRTGRQKAKELLERFDLVDAAGRPAATYSGGMQRRLDLAMTLVGDPRLIFLDEPTTGLDPRSRRTMWGIVRELVAGGVTIFLTTQYLEEADELADRIALLDHGRLIAEGTAEELKRLIPGGHVLLKFADPGRLDAARLVLGLGTPDPEALTLQVPSDGSVRVIRQVLAVLDEHSIEIDEMSMHTPDLDDVFLTLTGQNGDQDKEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A383</accession>
    <name>A0A1H6A383_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43188">
        <property type="protein sequence ID" value="SEG43188"/>
        <property type="gene ID" value="SAMN04489712_105183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG43188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="14935" checksum="1DACA33EE871295C" modified="2017-01-18" version="1">MNITEINGLPLPRELLDLLDSGRWRVPDDRARLAEVFGDRPVQPVFYQVDLMLSENAAWAGETSPYYLGEPDPIRPPGDIDPRRSLLIGDLGPDLPFALDYRGPGEPGVCYLASWGDRWVTVAESVADLAVRCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A853</accession>
    <name>A0A1H6A853_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome partitioning protein, ParB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44552">
        <property type="protein sequence ID" value="SEG44552"/>
        <property type="gene ID" value="SAMN04489712_105257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG44552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="29108" checksum="A1D53E3524E7F425" modified="2017-01-18" version="1">MTATPARGDATAHVLAQKITVLRIEKIEPHPSNVREDLGDLGDLSRSIRQQGILQPLIAQPSPDQPGMYRLLAGHRRYAAALLAGLDAVPVIIRHGVTDSGALELMLVENCQRQELNAMERAEALGALINRGYTQHQIAQKTGMSQSWVGYYLTLLDLDEDAREKVRTGELAVTTAINAVRKTRKKTRRKKGSTATYAWEPDHLTDRHPLARTARRLCDARDHTMRRRIGDTACGQCWETAIRLDERTVMGAVTNTKGDTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ACI0</accession>
    <name>A0A1H6ACI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45456">
        <property type="protein sequence ID" value="SEG45456"/>
        <property type="gene ID" value="SAMN04489712_105303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG45456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="228" mass="24182" checksum="0B1253C0361DF46B" modified="2017-01-18" version="1">MSSDIHVPPGESGTGGAAGDTDRGPVGGEPAVRVSDRGAATRSALLAAARDVFAESGFAQAAVTDIVARAGASVGSLYHHFNGKADLYLTLWEEFQVRQQERTREAVHAARAAGENDPMQLFIAGATAYLDGCLADRRIARLFIRGDGPPGFDRVMQKRLRKWARRNAALFHTPDGGVDEPLVTVLTGAMAAAVTEISLGEDEAASRRLASDIMTIIGTIRNPRAEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AEE3</accession>
    <name>A0A1H6AEE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46534">
        <property type="protein sequence ID" value="SEG46534"/>
        <property type="gene ID" value="SAMN04489712_105369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="293"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG46534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="471" mass="51284" checksum="D78A4B7131C6107D" modified="2017-01-18" version="1">MGTPITIDELRPLFLFEKLTDEQLTLLAAHGHVHEYKAGVEVCRQGDPAEYLYVLLDGEIALTKNVGGHEVELTRGARPGVYGGATQAYLGDRIEQRYQNTVRTVRRTRLFALPARKFAHIVSEWFPMGMHLLEGLFFGLSSTKQLVDQRERLTALGTITAGLTHELNNPAAAAARANAELGELLASSQQRLAKLAAHGVDCARLGDLVLTQERLAKRAAQAASRTPLQVSDAEDELGDRLEELGVADAWELAPSLVAAGFGGADITEVADLVGAEHLPAALRWLAEVLEIAQLQSEITDALTRITALLGSARQYSQMDRAPDQTVDLRELLNSTLTMLKRKIGEGVRVTTDYTADLPQVQVYAAELNQVWTNIIDNALYAMGGSGTLTVRTAREGDHALVEIGDTGPGIPEDDLPRIFTPFFTTKPVGEGTGLGLDISWRIVVDRHGGDIRVHSRPGDTRFQVLLPLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AK52</accession>
    <name>A0A1H6AK52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48911">
        <property type="protein sequence ID" value="SEG48911"/>
        <property type="gene ID" value="SAMN04489712_105504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG48911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14984" checksum="C66CC020BA7F54AD" modified="2017-01-18" version="1">MNSQLSAHIVGHLIAEPRIFELRNGVGCDLRVLVTRRYYDGLGIPSTAETRLKVVTYDTVMAERLVSEFKAGNFVELIADNVRGEKAWENKDGKWVSGSAVFHLAKIRHVPVEAPTEAPAEQATETPEVLARVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AKD2</accession>
    <name>A0A1H6AKD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein, Cas5t family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48537">
        <property type="protein sequence ID" value="SEG48537"/>
        <property type="gene ID" value="SAMN04489712_105481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG48537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="23709" checksum="E5E9B29A04B3A5A1" modified="2017-01-18" version="1">MSSQALEVTVTAPVASFRNPLYAGVQVSLPCPPPATVGGMLAAAAGGWSEMDPQTRFAMAFRCRGEGVDLETYHPLEATGKKADPTPRERAFLADVTLTVWLVDDIPLWERRLRRPRWPLRLGRSQDLVAVRTRCVELDDAPGRQGQAVVPADLSVQGRLLRLPTAVSLDRGHTRWDGYRYDTSGKADLPLGQADSEGRAVVLLPPAHPAHAEARSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ALE1</accession>
    <name>A0A1H6ALE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type branched-chain amino acid transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49538">
        <property type="protein sequence ID" value="SEG49538"/>
        <property type="gene ID" value="SAMN04489712_105537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="36"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG49538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="399" mass="42541" checksum="533820FFC331551A" modified="2017-01-18" version="1">MKRERSRWAAVTAGMAMVTAIAGCGGGGAGGASDDPYKIGMSMDLSGAIAFNGKPAAAGLRAYVSDLNKRGGVNGRKVDLKILDDGSDVAKGRVNIQQFSSEKRLAIFGFILSNLSLAGLPVAESRKTPIVGLGGPGKLFEPVKSYFFSYELRAERLESAILNYIATRTEGDGIEKPRVAVFSVDTPSNRDMVELAVKNIKSRGWTHTTTQYMPVAPTDVTAQAAEIKASDPDYVLLSHNDAGSLVAVRGLRAQGVTVPVINQWAGSADATLKQLGENYIAFRTYASPTEKNNPAVDAMKEAATKAGEAESMTNPYFTQGWVAGSLIEQTLKKCGQDCPSGEKFRDALEGLGEIDTNGLSGPLTVGPESHEMVSTVRFFTWDKAGDTAKPLTDWIKAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ALU5</accession>
    <name>A0A1H6ALU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE superfamily endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49689">
        <property type="protein sequence ID" value="SEG49689"/>
        <property type="gene ID" value="SAMN04489712_105544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG49689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="8995" checksum="46E31E0D99F4396A" modified="2017-01-18" version="1">MRRYLAARPWLTVHRLPAYAPDLNPAEGVWANLTTGLGNHRFDRLDDLKAAITARLRRLQHRPDLLTGFLAHTGLSLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AUU5</accession>
    <name>A0A1H6AUU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52291">
        <property type="protein sequence ID" value="SEG52291"/>
        <property type="gene ID" value="SAMN04489712_10620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9092" checksum="5B085011F9443779" modified="2017-01-18" version="1">MPVRPDAITAHAQTLGADAEALTECATRLRALAARLRTHKATPPWLYDTVNAHITACVVASADLAEASARLRAYAALTAEGPDDGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AVA5</accession>
    <name>A0A1H6AVA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA binding domain-containing protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52593">
        <property type="protein sequence ID" value="SEG52593"/>
        <property type="gene ID" value="SAMN04489712_10641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG52593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="9085" checksum="B4592B1E95D8DDAF" modified="2017-01-18" version="1">MEETSGRDPDVLTTRELAVKLGLSPQTVRRMANAGQIPALKTGKDFRYSWTAVREVLRQPHIQRRTSTDDPRPAREPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B0G2</accession>
    <name>A0A1H6B0G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Radical SAM superfamily enzyme YgiQ, UPF0313 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54132">
        <property type="protein sequence ID" value="SEG54132"/>
        <property type="gene ID" value="SAMN04489712_106138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025274">
        <property type="entry name" value="DUF4070"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13282">
        <property type="entry name" value="DUF4070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="156"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG54132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="480" mass="53856" checksum="BD1D633A2CFFC3F2" modified="2017-01-18" version="1">MQVKMILPALTEATSPFFRPIKYSLFPPLGLATLAGYLDPGDEVTITDEHVQRVDTSDEPDLVVIQVYITSARRAYELADHYRAKGAHVCLGGLHVTSLPEEAAQHADTIFCGPGEDTWPRFLADLRAGQPAPRYDSTERTLAGLPPIRRDLIERHRYLVPNSIVVSRGCPHVCDFCYKEAFFEGGKSFYTQTVDAALAEIDRLPGRHLYFLDDHLFGNARFATALFDGMRGMGRLWQAAGTVQAVLRPGLLEKAVESGLRSLFVGFETVNAGNLAEQRKWQNIDRDYGAVIRRLHDHGVMVNGSFVFGMDHDDPSVFDRTVEWAIGHGVETATFHILTPYPGTRLYDRMAKAGRLLHSDWDRYDTRTVVFKPARMTARQLEDGYWRAYRDFYRWGSILRGAATKPTLAGKARHAAYAGGWKKFEPAWDLIIRARQATRALPVLETVLAGGLRSRRPDTSGRLLPSVATADTERRQPERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5R9</accession>
    <name>A0A1H6B5R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_106274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55970">
        <property type="protein sequence ID" value="SEG55970"/>
        <property type="gene ID" value="SAMN04489712_106274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG55970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="487" mass="49472" checksum="A492E3AF16F690FD" modified="2017-01-18" version="1">MSSTPPGGRSRRLALVLLCAGMMMIILDGTIVTVALPAVQSDLGLSASGLAWVVNAYLIAFGGLLLLAGRLGDLVGRKRVFLAGLALFTLASLLCGLATTPAMLIAARFAQGVGGALASAVSLGMIVLLFPEPRERMRAIGAYSFVGAAGASLGLVAGGVLTDALGWHWIFFVNVPIGVLAGTLAARVLVADRGIGLGRGADVLGALLVTGGLMIGVYAIVETERHGWTSARTLGTGALSLALLAAFVLRQSRAAQPLLPLRVFRSRNVSGANLVQALVVAGMFGFQFVMALYLQRVLGYEAARTGWAMFPIAAVIGVLTLFVTARLIARFGARAVLAAGLLLIAAGLTLLTQVPEDARYVPDLLVPMMLAAAGAGLALPSMAGLGMSGATEQDSGVVSGLFNTTQQIGAALGSATLLTLAAGRADGLRAQGESAAAALTGGYHLAFGIGAGLAALALIVALAVLRTEPAAPTLQPQPEPEPRRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BHQ3</accession>
    <name>A0A1H6BHQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60230">
        <property type="protein sequence ID" value="SEG60230"/>
        <property type="gene ID" value="SAMN04489712_107117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG60230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="149" mass="14775" checksum="E13A8F0AC9A803F8" modified="2017-01-18" version="1">MGDRRRGHALTEGETGRITRFVILTLGLLGFVVFPGAGPSPVGSGIGPRTGAAQPPPAHQAPGRGRAGTAGGATGQTSTAETRSVASSTSAAPPYTALQEADPVTPAGGAEIALPRRSHTVPPDTRTAVPTGPRSLPSRGRAPPASTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BHR4</accession>
    <name>A0A1H6BHR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60259">
        <property type="protein sequence ID" value="SEG60259"/>
        <property type="gene ID" value="SAMN04489712_107119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="94" mass="10136" checksum="BA79E66432C558F0" modified="2017-01-18" version="1">MIAITRYRVPGEQAAAFAAELGSILESLAAAPGYLSGRIARTVDDPTLWAMVTEWDGAGHYRRGIGAYDVRMRLIPLSALAIDEPGAYEIVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BIK2</accession>
    <name>A0A1H6BIK2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Protein translocase subunit SecD</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Protein-export membrane protein SecF</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">secF</name>
        <name evidence="9" type="synonym">secD</name>
        <name evidence="12" type="ORF">SAMN04489712_107116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60205">
        <property type="protein sequence ID" value="SEG60205"/>
        <property type="gene ID" value="SAMN04489712_107116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="705"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG60205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="760" mass="80428" checksum="DE62FDC8307CD886" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BK32</accession>
    <name>A0A1H6BK32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_107178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61034">
        <property type="protein sequence ID" value="SEG61034"/>
        <property type="gene ID" value="SAMN04489712_107178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="358"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="611"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="402"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG61034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="687" mass="73553" checksum="701E1C5DE3EAF1AA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BL21</accession>
    <name>A0A1H6BL21_9ACTN</name>
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        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SAMN04489712_107211</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="SAMN04489712_107211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG61409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="127" mass="13680" checksum="5410E7636FB38DFA" modified="2017-01-18" version="1">MVLLRQLLGDVLRRLRLRQGRTLREVSAAARVSLGYLSEVERGQKEASSELLSSICKALGVPLSHVLREVADQLALAELQQEPVMAGAPPAHERLGEGLDQEAISADAIPATPEEITGEFRADMVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BP16</accession>
    <name>A0A1H6BP16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62448">
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        <property type="gene ID" value="SAMN04489712_107297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
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    </dbReference>
    <dbReference type="Pfam" id="PF00561">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="91"/>
            <end position="462"/>
        </location>
    </feature>
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        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG62448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="531" mass="57761" checksum="B33B081E52853EDF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BVF6</accession>
    <name>A0A1H6BVF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64643">
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        <property type="gene ID" value="SAMN04489712_10842"/>
    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5009294129" evidence="2">
        <location>
            <begin position="29"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG64643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="26482" checksum="6125D7E027AD687D" modified="2017-01-18" version="1">MRRSLRAGAAAAMAGVSLAACGTASSQASSADPVAPPVAPPPPPTAASPAPPPSPAGQARADAVARPTRLSKGWRITVYYTAVESFHTGPRKRVRGCLVSGCARPKADLGSYPAGFVKAVQTEGAGRITSGPYKGRYLTWSRRVGHFWLDEVARDAVNRPLRPWVTAAADRSVLERGSRFTITGCGKGWAGRPVPTATCERFRAARWTVVDVFAPGHGGEHHADVYIGEETGPGFTTSPFYTTLNGATLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXU4</accession>
    <name>A0A1H6BXU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase components of ABC transporters with duplicated ATPase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_108108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65472">
        <property type="protein sequence ID" value="SEG65472"/>
        <property type="gene ID" value="SAMN04489712_108108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="326"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="358"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG65472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="532" mass="57577" checksum="2F792B0AFF57292B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYR7</accession>
    <name>A0A1H6BYR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe-S cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65276">
        <property type="protein sequence ID" value="SEG65276"/>
        <property type="gene ID" value="SAMN04489712_10891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG65276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="373" mass="40682" checksum="2B7601B2C0FCA903" modified="2017-01-18" version="1">MGLETKPLSTLHERSSYDVADFPVPTGREEEWRFTPLRRLRDLHKGAEGLGKALVEVEAAPEVKVERVGRDDPRLGRAYVPGDRVSAQAYAAFTEATVLTVPKEAVASRPTVLRINGEDAGSAAYGHTTVIVEPFAQATVVLAHRGSATYADNVEFVVGDGAKLSVISLQDWEDDSVHLSHQHARLGRDASFTGFVVSLGGDLVRIAPSVAYDAPGGDAELYGVYFVDAGQHLEHRLLVDHAVPHCRSRVDYRGALQGQDAHAVWIGDVIIRAEGEGTDTYELNRNLVLTDGTRVDSVPNLEILTGEVVGAGHASASGRLDDEHLFYLQARGIPRDEARRMVVRGYLGQLVDRIEVDEVREKVRAAIEAELDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZ69</accession>
    <name>A0A1H6BZ69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65962">
        <property type="protein sequence ID" value="SEG65962"/>
        <property type="gene ID" value="SAMN04489712_108153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021857">
        <property type="entry name" value="DUF3467"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11950">
        <property type="entry name" value="DUF3467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG65962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="9887" checksum="9EDFB9E6EB6CF9B8" modified="2017-01-18" version="1">MPEDAEVGVYAGFASVWRTRESFVLDFATEVRPPEVTRDPDSGAQFVHVPARVVARVRIPPGQVWELMKALEQNLSAYERETGGRGDGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8C2</accession>
    <name>A0A1H6C8C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69158">
        <property type="protein sequence ID" value="SEG69158"/>
        <property type="gene ID" value="SAMN04489712_10956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="111" mass="11759" checksum="250944D79117115B" modified="2017-01-18" version="1">MSGPATTERLFSWTVVERGGDPPALGAVGVCDDQGKAVRRLAEALREAPAGALGLVHSVTRPWWTDGYWYGDLLVRVQVDSGTGTVVARRGGGQPMDDVFAEAARVCAQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8D2</accession>
    <name>A0A1H6C8D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69017">
        <property type="protein sequence ID" value="SEG69017"/>
        <property type="gene ID" value="SAMN04489712_10941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="28005" checksum="664A60BBA0A5E3CC" modified="2017-01-18" version="1">MQRTPSGAIVWRVHDDGPDRGIAEVVMDRPPVNALTVAGWFELADTVRTLGGDPAVRALVLRAEGRGFNAGVDIKELQADPGYDALIGANRGCFAAFAAVYECEVPVVAAVNGFCLGGGIGLVGNSDIIVAAEDATFGLPEVDRGALGAATHLARLVPQHKMRAMVYTAEPATARELHAWGSVLAVVPADRLRDEAFAVARGIAAKSGRVIRAAKESLNGIDLWDVRRSYRYEQGFTFELNLSGVSDEARAAFVEGRDAKFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKF5</accession>
    <name>A0A1H6CKF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73491">
        <property type="protein sequence ID" value="SEG73491"/>
        <property type="gene ID" value="SAMN04489712_110116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="99" mass="10784" checksum="8D1C88087847F2C3" modified="2017-01-18" version="1">MSIKTLEPGAGGVSPPVHGERPRETADPTSRYTRTDQGQVRPLDGEEYLRGLRAEFPHVGFVADIRAGVWMAVKGKDLFLRADSGAELCEQLLAALGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLL8</accession>
    <name>A0A1H6CLL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron complex transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73657">
        <property type="protein sequence ID" value="SEG73657"/>
        <property type="gene ID" value="SAMN04489712_110137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294977" evidence="1">
        <location>
            <begin position="25"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="114"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="42682" checksum="71D77A0B97F2AE0C" modified="2017-01-18" version="1">MSMGVSRPLTGVLLALSLAVTACGGDGRESEPSAGTGCVTDFDAARDYFPVKQTIRHATNFTLTYAKNYQVVTVKQPSPGAKSETYVLVRCGTPAPELTGPLSGAVTVQTPVRTMFAGSTTHLPFITDLGVLDRLKGVGTAGLVTSPQVRERVTAGAITEYADITGQEIDTEKVIGARPDVLMTDGREVGSYGTLRKAGVRIVANAEWQETTALGRAEWIKFVAALTGTEAKATEVFDGVAARYRSLAAKAKTAEPVTVLPGQMFQGQWAIPNGDSFMAKLLKEAGGTYAWADTEGTGSATFDLEAVLARARDAEIWLPQVSEWKTLADVRKADSRYAEFAAFRSGKVWGINKALGPGGGNDFYERGVGHPDLILADLVAVLHPDLMPGHSFTFYQQLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLR3</accession>
    <name>A0A1H6CLR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome bd-I ubiquinol oxidase subunit 2 apoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_110144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73707">
        <property type="protein sequence ID" value="SEG73707"/>
        <property type="gene ID" value="SAMN04489712_110144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG73707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="358" mass="38585" checksum="254B18F6A6CB19AB" modified="2017-01-18" version="1">MELTTVWFLLIAVLWTGYFLLEGFDFGVGVLLPVLAPRGAAHAETDRRVMINSIGPVWDGNEVWLLVAGGATFAAFPEWYASMFSGFYLALLLILVALIVRGLSFEYRGKIDGDRWRRTWDRVIFWGSAVPAFLWGVAFANIVQGVPLNADHHYTGSLFTLLNPYALLGGLTTLAVFTLHGAVFLALKTHGHVRDRARALIRRAALPVVAVAAAFLVITGLRFGVPWTWATTAVAAAALAGGVAATLRGRDGWAFAGTAIAIVATVVTLFGDLWPAVLPSTTDPAFSLTVQNAASSPYTLKVMTWVAALFTPLVVGYQAWTYWVFRKRLTRESIVPAAPSPASAPADGPTVEPEKSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQL1</accession>
    <name>A0A1H6CQL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75280">
        <property type="protein sequence ID" value="SEG75280"/>
        <property type="gene ID" value="SAMN04489712_11110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="28752" checksum="AA7B338DE04654EF" modified="2017-01-18" version="1">MTTVGIATGAGRGMGLACARRFTGMVDTLLLVDRDEATVAAAAEDLSASGGGTAVEPFVLDITDRDGLARLAARVSELGTLRAVAHAAGISPTMADWRRILTVDLVGTALLAEALRPLATAGTAMVCFASMAPVLARTRPDPAVAAILDAPLHERFLDRLHEALGPAIEDPGAAYAFAKHGVHRFVQQEATRLGPVGARVCSVSPGIIDTPQGRQEAANHPSMDRLVQQTPLGRAGRPEEVAAVVAFLLSAEAGFLTGTDILIDGGVCAAVHRQATGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSU0</accession>
    <name>A0A1H6CSU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dye decolorizing peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_111122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76099">
        <property type="protein sequence ID" value="SEG76099"/>
        <property type="gene ID" value="SAMN04489712_111122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295165" evidence="5">
        <location>
            <begin position="31"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG76099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="42786" checksum="05C89440020D9565" modified="2017-01-18" version="1">MRRDLTRRGLILGGAVAAGSTLAATSGYLAAPRPDDQPTSPAPSTAAPATEPFHGPHQAGIATSPQTHAALLGLDLRPGTDREALGRLMRILTDDARRLTEGQAGLADAQPELADIPARLTVTFGFGPGLFTAAGLKHQRPAIDLPKFSIDKLQDRWSDGDLLVQICADDPVTLAHALRLITKDARAFATVRWTQRGFRRPPTSQPAGHTQRNLMGQLDGTVQPTDLGKAVWISDGPAWLHGGTLMVLRRIHMDLEKWDRADEAAKEFSIGRRLATGAPLTGHNEHDEPDLHAKDHVGFPVIDDAAHIRLAHTADPAQRMLRRSYNYDETVSADGVTDTGLLFISYQADITRQFIPVQQRLAATDLLNAWTTPIGSAVFALPPGCTTGGWIGETLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CU52</accession>
    <name>A0A1H6CU52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subtilisin inhibitor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_111156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76378">
        <property type="protein sequence ID" value="SEG76378"/>
        <property type="gene ID" value="SAMN04489712_111156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SSI" evidence="3">
        <location>
            <begin position="66"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG76378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="157" mass="16524" checksum="16F5ABF4A6878241" modified="2017-01-18" version="1">MEPRRTPVRRILMPYRTPLITTAGLACLAVIALAGCGSEDNGGGSPSGTLSPAAQTRLTVEVRPSPQGTPKTWTLTCDPPGGTHPRAAAACQALAKAKDPFKPVPKDAICTEIYGGDQVATVTGTWRGTPVNARFTRLNGCEIDRWEKVAPLFGDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CU58</accession>
    <name>A0A1H6CU58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76550">
        <property type="protein sequence ID" value="SEG76550"/>
        <property type="gene ID" value="SAMN04489712_111177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="638" mass="67261" checksum="8EF2DC7FEF3ECF9A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUV1</accession>
    <name>A0A1H6CUV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76800">
        <property type="protein sequence ID" value="SEG76800"/>
        <property type="gene ID" value="SAMN04489712_111208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="35" mass="3707" checksum="C2C7797C8FC8BCAC" modified="2017-01-18" version="1">MGDKHAGKPQETKPFEPKDKPSPDGSKGGGGKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV04</accession>
    <name>A0A1H6CV04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76637">
        <property type="protein sequence ID" value="SEG76637"/>
        <property type="gene ID" value="SAMN04489712_111188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="763"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="832" mass="85844" checksum="0D69BB55E3829D4C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CWA5</accession>
    <name>A0A1H6CWA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CubicO group peptidase, beta-lactamase class C family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77097">
        <property type="protein sequence ID" value="SEG77097"/>
        <property type="gene ID" value="SAMN04489712_111248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="355" mass="37607" checksum="2577189273992F12" modified="2017-01-18" version="1">MNGAALDDLLGPVLGAAPGACAVVAGAVRGGEHLIRCRGTSARHVRGAEPEPAVPGTRFEIGSLTKTFTGLLLAEMVAAGQVGYDDPVNHYLPYRARRTGPDITLLHLATHTSGLPCLPPGLLRRAMPRMFTNPYATYTTADLLAAVPRARLRARPGTRVRYSNFGVGLLGHLLARAAGGGTRYEDLLDARVLIPLGLTGTDCDPYRPQATGYWHGRARPTWLIPGMAGAGALRSTARDMLRYLTALLDPATVPGPTLGAALADMRRPRAVVPGNEPRPLIWNLHRGDDHDLLHHSGVTRGFTAFAGFGPQTRVALVALTNTTASLRTTFVQAAYDALDALAAQQSRSAGQGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZ78</accession>
    <name>A0A1H6CZ78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78421">
        <property type="protein sequence ID" value="SEG78421"/>
        <property type="gene ID" value="SAMN04489712_11275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024029">
        <property type="entry name" value="Pyridox_Oxase_FMN-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04025">
        <property type="entry name" value="PPOX_FMN_DR2398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="202" mass="22611" checksum="3E9C36B3F68BC78A" modified="2017-01-18" version="1">MRTEAELREIVQEPSQTIWDKDIARIDEHARTLIAHSPFVLLATANSEGTCDVSPRGDPAGSVLVLDDHRLVLADRPGNHRLDSIRNVLHNPHVGLLFIVPGMNETLRVNGRATLVSDAPFFEDLTVQGKRPRLAILVEVEELYMHCAKAFLRSSLWRPETWPDRGSLPTLGRIAKDHLGLKEISAEEIDKGLDLDAETNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1I2</accession>
    <name>A0A1H6D1I2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol acetyltransferase</fullName>
            <shortName evidence="2">MSH acetyltransferase</shortName>
            <ecNumber evidence="2">2.3.1.189</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mycothiol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mshD</name>
        <name evidence="4" type="ORF">SAMN04489712_112187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol</text>
            <dbReference type="Rhea" id="RHEA:26172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16768"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="EC" id="2.3.1.189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. MshD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79239">
        <property type="protein sequence ID" value="SEG79239"/>
        <property type="gene ID" value="SAMN04489712_112187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035447">
        <property type="term" value="F:mycothiol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01698">
        <property type="entry name" value="MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017813">
        <property type="entry name" value="Mycothiol_AcTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021524">
        <property type="entry name" value="MSH_acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03448">
        <property type="entry name" value="mycothiol_MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="155"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 1" evidence="2">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="240"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="272"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG79239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="299" mass="32306" checksum="A43EC817A2519C24" modified="2017-01-18" version="1">MGERDLVITDGLGEPQAGEVLALAEAATRRDGVAPLSEQSLLTLRAGRAHALLVLEDGAVAAYAHVDPVPEEDGGGASGELVVHPDRRGRGHGRALLRALREEARGPLRVWAHGDLPAAAALAGSEGLRRVRVLLQMRRPFDGTPLPEVTVPDGVQIRAFEVGRDEDAWLRVNGRAFADHPEQGAWTLEDVRARQNEPWFDPAGLFLAERDGQVIGFHWTKVHPEPVGEVYVVGVDPSAQGLGLGRVLTLVGLHHLRERGLPAVMLYVDEANRPAVRLYESLGFTRHAVDVMYGAPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1N3</accession>
    <name>A0A1H6D1N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78833">
        <property type="protein sequence ID" value="SEG78833"/>
        <property type="gene ID" value="SAMN04489712_112130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="41" mass="4648" checksum="CAA1E94362B3225B" modified="2017-01-18" version="1">MIESAMPYEPPALIELGDFTELTRITDKGGYVDLFGGWWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D228</accession>
    <name>A0A1H6D228_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type VII secretion integral membrane protein EccD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_112203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79352">
        <property type="protein sequence ID" value="SEG79352"/>
        <property type="gene ID" value="SAMN04489712_112203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044049">
        <property type="entry name" value="EccD_transm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19053">
        <property type="entry name" value="EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017804">
        <property type="entry name" value="Secretion_EccD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="EccD" evidence="5">
        <location>
            <begin position="97"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG79352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="466" mass="48216" checksum="B7348B962F846193" modified="2017-01-18" version="1">MNPPAGLELCRVTIVAPRRRIDLSLPSDVPLAHMLPTLLRAAGAELADTGLAHSGWVLQRLDEAPFDLAQNLGQLGVKDGEILYFRPRLAQLPELSFDDVADVIASGIRERPDRWRPATTRSFWLGSAAAALLVGAAVIALSGPPWIAPAIAAGAVALVALIGAATLSRAFGDSGAGTMLGYVALPHAFLAGLLGPAESDLPILHTGAPHLLAACGVTALAALIAAFVVADGLPPFLGVFFAGMFGLLGAGIALFFEDTEPAGIAATIAVLLMAFAALVPSLSFKLARLPLPPVPANADELRNDTEVVDGRTVLTRTAAADRFATGLVACIALVSIGALLFLFTEDGWIAPTLTAAMSVSLLLRARVFRGIAQRAWLLVAGLVGLGLLEVHTALHGGQVAALAMALVPLVVLTGIVIGVVLWLPGHRPTPFWGRAGDIVDLLVVITLIPLALAVLDVYARVRGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D570</accession>
    <name>A0A1H6D570_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80401">
        <property type="protein sequence ID" value="SEG80401"/>
        <property type="gene ID" value="SAMN04489712_11375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046306">
        <property type="entry name" value="DUF6421"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19985">
        <property type="entry name" value="DUF6421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="699" mass="76962" checksum="B2C3C04DF56809F7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8G7</accession>
    <name>A0A1H6D8G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_113148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80766">
        <property type="protein sequence ID" value="SEG80766"/>
        <property type="gene ID" value="SAMN04489712_113148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295640" evidence="2">
        <location>
            <begin position="35"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="62"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG80766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="467" mass="50954" checksum="B23F46A2BADA3C64" modified="2017-01-18" version="1">MRASSALSKSRHAAVALCTGLALTTGVLAAPAQAAQPAQPAAPATSPEAAQTPALPSGRTQYRTLADYQSDMAALAGRRPDLVKQVTLPHRTSEGRAVTGVEITDDVQQQDGKPVLLITGMHHGNEWASGEVTMEFGHDLVANHGRDKRITRLLDQVRVLLVPIVNVDGFVRNTRRTATNVDMNRNYGFGWSPNEPFPGSAPWSEPETRNVRDTISSRQVTTYLTMHTCLSNMLYPPLQLKAGLPQDIDAFRSFADAMGTQNGYYHTTSAEDYETAGEVIDWSYYATRGLGVTVEVCTTPMGLPRTFESLVPDQYWGVGPNAGKGNRGAFLVAMEQAADRAAHSTITGHAPKGAVLTISKDFDMWTNPVPQPDGTSRPVSFPNRLTSTMRADERGGHFVWDVNPSVRPIPPYQADGVHGNRTGFLQESWTLTCARPDGKVLQTLKLKVDRGKSVEANLHECRKLFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8J0</accession>
    <name>A0A1H6D8J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81747">
        <property type="protein sequence ID" value="SEG81747"/>
        <property type="gene ID" value="SAMN04489712_114133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="130" mass="14349" checksum="7A7BB0994E7BBA01" modified="2017-01-18" version="1">MRIGEMVRRTGVSERLLRYYEEQGLLAPTRLSSGYRVYNDADVDTVRRIRTLLAAGLSTTTIAQVLPCVRDDGPNLAPVCPDLVATLRRERERIAHAIKNLQVSQDMLDAVIAAGPAETDATVHQPLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBD9</accession>
    <name>A0A1H6DBD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82631">
        <property type="protein sequence ID" value="SEG82631"/>
        <property type="gene ID" value="SAMN04489712_11553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="100" mass="11692" checksum="77E4ACCA5DD7E502" modified="2017-01-18" version="1">MSKTDKTRPWWVGMADAPMVTCVPVHDHRFGPCTLPDEITADSASLNRRTSGCHWHATTYFLFDCGGVGGGREWYHIRRQERRRSRHQARRKLRTWHGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBR4</accession>
    <name>A0A1H6DBR4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_114170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81906">
        <property type="protein sequence ID" value="SEG81906"/>
        <property type="gene ID" value="SAMN04489712_114170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="127" mass="13911" checksum="ABC1EEBC2FBA5530" modified="2017-01-18" version="1">MACRISELVIDCADPERLAAFWSEVLGYVELDREDDGSIEIGPPDTGFGGPQPTLVLSPSSDPRPGKLRLHFDVNATDRDQDAELERLLALGAKPADVGQTGTENWHVLADPEGNEFCLLHTRFQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEI8</accession>
    <name>A0A1H6DEI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83798">
        <property type="protein sequence ID" value="SEG83798"/>
        <property type="gene ID" value="SAMN04489712_11669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="33"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="426"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG83798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="518" mass="54493" checksum="E33C66A0D1AA0F5D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF89</accession>
    <name>A0A1H6DF89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83742">
        <property type="protein sequence ID" value="SEG83742"/>
        <property type="gene ID" value="SAMN04489712_11659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="27987" checksum="0881BCA716F14A12" modified="2017-01-18" version="1">MGSMNGRVALVTGASRGIGQRIAERLAAEGAAVALVARTVAPGTSALPGSLQEVAGRIRARGGVVAALPADLTSPEEVETLVARAEEALGPVDTLVNNAGVNFYGPALEVRPRRYALMFQMMVHTPFRLCQLAVPGMIERGRGWIVNITSKQARHPLGPPYPDWAADGCVPYGMCKAALDRLTTGLAAEVHGTGVSVNALGTSGLVMTPGVAVVSPHTPDNAPVEDDGAMADAALLLCGADPGTVTGRIAYSMELLGRPFPEGPWALSATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF99</accession>
    <name>A0A1H6DF99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83752">
        <property type="protein sequence ID" value="SEG83752"/>
        <property type="gene ID" value="SAMN04489712_11661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="70"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="402" mass="45548" checksum="2DE0C4C7972F0500" modified="2017-01-18" version="1">MSFTWFISVDDHLIEPSRLWQERLPARWRDTGPRIVRDGDSEFWVYEDRQIVTTGLNAVAGKRREEFSPEPITYDEMRPGCYDPAARVADMNQGRVLASMLFPSFPRYCGQVFHEARDKELALLCVRAWNDFILEEFAQAHPGRFIPMMIIPLWDPVAAAAEIERTAARGAKSIAFSENPAKLGLPSIHTGHWDPVWRACDETGLVVSMHVGSSSNLLRTSDDMPTLAFMAYSAAVNQAGTLLDWLFSGNFARFANLKIALSEGSIGWIPYFLERAEQVVDKQKYWASRFDIDMNAAHDRGEVKSAARFDLDTDIRRLFRDHVYGTFIEDHAGLRLLDVIGEDNVMLECDYPHSDSTWPDTIEMAGKWLGHLPEDVQHKITMGNAARVYDFTPADPATIEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIT7</accession>
    <name>A0A1H6DIT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="6" type="ORF">SAMN04489712_11764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84763">
        <property type="protein sequence ID" value="SEG84763"/>
        <property type="gene ID" value="SAMN04489712_11764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="102"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="110"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="200"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG84763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="357" mass="37749" checksum="3BC6DF7246CA94A3" modified="2017-01-18" version="1">MSNLFDSGLSRYGWTAALDHAFTEHHKAGLMPARIVRVNRGLCDAVTESGPTRARIAAAYSPDPLQAPCTGDWAALRPGPDPELVALLPRSSAIVRSSASRSSHGQVLAANIDIVAVVVSLAVALDAARLERLLALAWDSGARPLIVLTKADLAPDPAAAHAEAAALAPGVDVLVTSVTTGQNLDVLTALLSGSTTVLLGSSGAGKSSLGNALLGDELLATSEVRAQDGKGRHTTVRRELVPLPGGGVLIDTPGLRGIGLYDTTDGLEHVFAEIEDLARDCRFGDCAHHTEPGCAVLAAIEAGELTERRLNSYRKLQRENAWAASRKDARLRAERSNRQKAITSQLRATYKFRNRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIZ4</accession>
    <name>A0A1H6DIZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA (Guanosine-2'-O-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84833">
        <property type="protein sequence ID" value="SEG84833"/>
        <property type="gene ID" value="SAMN04489712_11776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="197" mass="21202" checksum="35E4C4216B8F8026" modified="2017-01-18" version="1">MTARHAPHQPERRRQMRPTDVKRLNRDWRRRTEGRLALLVESVTQPFNTGSILRSAAAFGVEHLWLAGNATLPTHRNVGKTALGTERLVPWSQAGTPADAVAAAHAEGFRVVALELTHDAAPLHQAPLDGDICLAVGGEDHGCSPALLAAADAVAYIPQIGRVGSLNVAVATAIALAEIRRREWAPQPGPHDHHPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL78</accession>
    <name>A0A1H6DL78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_118105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85909">
        <property type="protein sequence ID" value="SEG85909"/>
        <property type="gene ID" value="SAMN04489712_118105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019662">
        <property type="entry name" value="DUF2516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10724">
        <property type="entry name" value="DUF2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="109" mass="11820" checksum="68EA7F9E62450033" modified="2017-01-18" version="1">MSQGLNYFFWFLAIIAFGFELWALFDALRTPAGAYAAADKQNKNLWLILLVVACVVGLGGAVNMLHLLSILPIAAFLVAAIYLADVRPAVRQYRKRGGGSSSSGPYGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLD0</accession>
    <name>A0A1H6DLD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_118134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86028">
        <property type="protein sequence ID" value="SEG86028"/>
        <property type="gene ID" value="SAMN04489712_118134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="12"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="44126" checksum="87D4A10C02C099B6" modified="2017-01-18" version="1">MTLDERPAPRLRELDLLRFLAAVVVMLYAYTRRDRPLWGLGSGEVFPELEAVAHFGGIAADLFFVLSGFVILMTVWDRRPGDFARSRLVRLLPAYWFAVTLAVVVYLATGQADPAGPNEMYDGTLWRFLPNLTMLQEGAGFSGMEAGYWTLWVELHFYALIALLSWWGISYARCVWFMSAWLLAGVYAQEGKSEIFQVLLMPDWAPCFIAGMALFLVYRFGGNIVLWLLVGFCWALASYHRLREFRPDPVLNDWTLYHWAAPLAVTLIFVVMALVATGRLGFLRGRWPTALAALTYPMYLMHETIGRVVIVELRPHLNRWAVLALAVTATVAASYAVHRFVERPLAPLMRTRIQQALARIRSGEDGRPAGDGPAARTGPADAVAPRPVHAPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLT9</accession>
    <name>A0A1H6DLT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, Rv3520c family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86174">
        <property type="protein sequence ID" value="SEG86174"/>
        <property type="gene ID" value="SAMN04489712_1196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="38042" checksum="55A3E8A6ABDD5D33" modified="2017-01-18" version="1">MKFGMPIPYAAGFKQSVEGLQALEDAGLDVVTVPEAYTFDSVSQLGYIAARTSRVELATSILNIYSRTPALLAMTAAGLDYVSDGRFSFGVGSSGPQVIEGFHGVPFHAPLGRTREVVAICRQVWSGEKVELHGHYYDVPLTPERGGSGLGKSLKLINPPVRPSIPMTLAALGPKNIALAAELFEAWQPIFYYPELADEVFGESLAEGRAKRDPLLPDLRVIADAKFFISDDEHELEAARAKVRAGLALYIGGMGARGKNFYHQLVTRLGFGAAANEIQDLYLGGSKAAAAAAVPDSLVDSISLVGGPDHIEKRVAAYAAAGVGQLNLSPVSTDNDERARQFAHLRKIAEAIVGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRN1</accession>
    <name>A0A1H6DRN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88027">
        <property type="protein sequence ID" value="SEG88027"/>
        <property type="gene ID" value="SAMN04489712_12160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="366" mass="40136" checksum="A3CD3F529DB327BC" modified="2017-01-18" version="1">MTVLSIQALNRATLARQLLLDRADMPVRDAIAHLCGLQAQEPQEPFVGLWSRLRAFDPAVLSDLLVGRSVVRTHLMRRTVHLLTADDVLAWRARHDAMLRQRVLGTYRHELAGIDLDELAAAGRAVMADGRPRSMAELARALTERWPTSEPRALGEMLIAALLPMVQLPPRGLWRTRAGVRNMLLSSWLGREIDPPSPDGSDPVGQALVRRYLAAFGPAATADLRAWCGLAGLPAAVTAIRQELVTFRDERGRELLDLPDAPRPDPDTPAPVRFLPAFDNAILGYHDRSRIIDDAHRGLSVAGARVVLVEGRVSATWIVQAGTVVVTPLRRFSRADCTAVAEQGRALASFLSDDDSDRVRIATSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSB0</accession>
    <name>A0A1H6DSB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholesterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88159">
        <property type="protein sequence ID" value="SEG88159"/>
        <property type="gene ID" value="SAMN04489712_12188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_oxred_C" evidence="1">
        <location>
            <begin position="467"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="537" mass="57022" checksum="D67438AF58610FB3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUN6</accession>
    <name>A0A1H6DUN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89067">
        <property type="protein sequence ID" value="SEG89067"/>
        <property type="gene ID" value="SAMN04489712_12313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="89"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="121"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG89067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="30834" checksum="6144F0FB0BD80D05" modified="2017-01-18" version="1">MNDATNDVREHAGEHDAWLAALDGELRRRGIEPGLARHVVAEAAAHLRDSRQPPLAAFGRPDVYAAAVADSVGEPVSGARRPPPGPVRLEARGIVKRYRRRPVLAGVDLTVRAGQIAAIVGANGCGKSTLLRICAGMVSPDRGRVHVHGTLGYCPQDGGTSEFLVPDEHFVLVGAGRGMGRAAAVGAGRAHAAALDWNPAGAGQARLLSGGTRQKLNLVMAGLGDPDVLLLDEPYQGFDRGAYVDFWHQLWRWRDAGKAIVVVTHLLDRLDRVDTVLDLTPVPEPEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVP6</accession>
    <name>A0A1H6DVP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ruvA</name>
        <name evidence="10" type="ORF">SAMN04489712_12354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89269">
        <property type="protein sequence ID" value="SEG89269"/>
        <property type="gene ID" value="SAMN04489712_12354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG89269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="20534" checksum="0E53C4B2726D1AB4" modified="2017-01-18" version="1">MIAFVSGQVTAAGPDGAVVDVGGVGLSVQCTPATLAGLRVGEQARVPTSLVVREDSLTLFGFADDDERAVFELLQTASGVGPRLALAMLAVHSPNALRRAVAAEDLTALTKVPGIGKKGAQRIVLELKDRLGAPSGDDAGLPVPARAEPWRAQVHTGLINLGWSGKDAEAAVDAVAAELDGGQVPPVAVLLRSALKKLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWB6</accession>
    <name>A0A1H6DWB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 6">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89627">
        <property type="protein sequence ID" value="SEG89627"/>
        <property type="gene ID" value="SAMN04489712_12410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG89627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="17927" checksum="2A4E64B3516313E3" modified="2017-01-18" version="1">MIVSLIVAAAANEVIGRDGDIPWHLPGDLRRFRRLTSGHAVVMGRLTHESILSRLGRPLPGRTSVVVSRTLREAPGVLVAPSVPEALRIAREQETGGQIFVIGGASVYREALDAVDRVHLTRVHQDFTGDTAMPGNWLDGFTEVSREGPLEESGLTYSYVDYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWP1</accession>
    <name>A0A1H6DWP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89678">
        <property type="protein sequence ID" value="SEG89678"/>
        <property type="gene ID" value="SAMN04489712_12424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG89678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="22320" checksum="70D6B02C7D40D0C2" modified="2017-01-18" version="1">MTAQARTAAHPGEPVTATARQEQDAADLTRSLRDPEHFTAIYDRHFTAVYRYVAGRLGPQVADDLAAETFLVAFRKREAFDPRRGALRPWLFGIATNLVAQHKRDETRRYKALARAGAEPSSTAGHEDRVVRLVAAEGMQPRLARALASLSQAERDVVLLVALSGFAHDEVAQALDIPYGTVGSRLSRARKKLRAALDLEVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX64</accession>
    <name>A0A1H6DX64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89871">
        <property type="protein sequence ID" value="SEG89871"/>
        <property type="gene ID" value="SAMN04489712_12496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="61" mass="6751" checksum="3979D8CA9E11D386" modified="2017-01-18" version="1" fragment="single">MTANPIVPGDLFARHQTITGLRALADFLEANPAVPVDEYGEDYSVYTRGHCDTGQRTEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E041</accession>
    <name>A0A1H6E041_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-(Acyl carrier protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90356">
        <property type="protein sequence ID" value="SEG90356"/>
        <property type="gene ID" value="SAMN04489712_12612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="17"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="690" mass="73388" checksum="F288FABD6389168F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E230</accession>
    <name>A0A1H6E230_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91389">
        <property type="protein sequence ID" value="SEG91389"/>
        <property type="gene ID" value="SAMN04489712_1292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="92" mass="10481" checksum="9E32DD4FADC1122A" modified="2017-01-18" version="1">MPRATRIARTSREGVLLLEEHRDREIDELWLDHDLGGDDSIMPVVAVLERAAFDGRPFRIGMIFVHSADPSGAETVVRVLKRWNYPVRRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2V8</accession>
    <name>A0A1H6E2V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dolichyl-phosphate-mannose-protein mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_1323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92048">
        <property type="protein sequence ID" value="SEG92048"/>
        <property type="gene ID" value="SAMN04489712_1323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="70"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG92048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="511" mass="54959" checksum="CCD4CE35EC126B06" modified="2017-01-18" version="1">MIPPTPVESGSSEQESQPTGAPPAVAWRPVLLIAGTLGAVLLVFSARYGYHRDELYFRVAARHLDWGYPDQPPLVPLLARAITAVFGDSLVMLRVPSALAAAAGVVVAALTARELGGAKRAQLLTAGAYAVCPFAVAIGHLLSTATFDVLLSTVVAWLAVRWVRTRDQRLLLAIGAVAGLAVNVKYLAGMLLAALVAGLLLAGPRDFLRRPMLFAGAAVLVLAAVPGLLWQARHGWPQLEMSERIAEEGDFGGRAGFVPFQLLLTGVVLSWLWIYGLWRLLRSPDLARHRFLGYGYLLLCALFLVTAGKPYYLAGLWAALWAAGAVEVERRGAPRGWGWAVSVPAYAITAVVTVATTLPVYPVDRLADTPQPAINADASETVGWPRFAAEVARVHRSLPPDERSRAIILTANYGEAGALDLYGPDLGLPRPYSAHNGYWYFGRPADTGGPVIVVGPEGSAALQRHWTEVTVAGRIDNGVGLDNDEQGLPVWVCRGQREPWAVLWPRLKHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E303</accession>
    <name>A0A1H6E303_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91731">
        <property type="protein sequence ID" value="SEG91731"/>
        <property type="gene ID" value="SAMN04489712_13034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12706" checksum="F646C20277D853DE" modified="2017-01-18" version="1">MAASAPLNAMLAGADYEIVREGPWNRKRSRAAIGVVRELKLSRPVDTAMRKWPALIWDDSGDTYLSRGFNASYSDMSTLVVYIDASRGVVALTPGPEAKVVVGPGNEWTKSLKKGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3J7</accession>
    <name>A0A1H6E3J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91869">
        <property type="protein sequence ID" value="SEG91869"/>
        <property type="gene ID" value="SAMN04489712_1318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="373" mass="41264" checksum="E4AC9A4FE7C3D000" modified="2017-01-18" version="1">MTGIDREFIGLPSPAIGRAGAGNHPLQGIYYTPSGKRPRTALIASHYNVDFTEHYIATRMAERGYGFLGWNTRFRGAEHFFTLDHALAEVGVGVAWLRSQGVEQVVLLGNSGGGSLMSAYHSQSREPNIRPAYGRGQVFEPALHLPPGDLMIFLAAHPGRPEWITRTMDPSVLDEADPNSVDPELDMFDPAHGPTYSPEFVARYRTAQVERNDRLTAWCKEQLAAMAGRPARDRIFSMPRTWADLRYLDPTIDPSGRPTPMCYFGDPKHANYGVFGVGVVSTLRTWLNMFSLEESDCVAAKHLQRMDLPTLVVQPDADTGVFPSDAQALYDGAASKDKELITLPGDHYFVEPVDARDVVADTLADWLASRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E418</accession>
    <name>A0A1H6E418_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91635">
        <property type="protein sequence ID" value="SEG91635"/>
        <property type="gene ID" value="SAMN04489712_1304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="971" mass="102532" checksum="ECDA72DDA0C6778F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5C9</accession>
    <name>A0A1H6E5C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92095">
        <property type="protein sequence ID" value="SEG92095"/>
        <property type="gene ID" value="SAMN04489712_13221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="649" mass="67226" checksum="98D656F5EDF62E52" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6X1</accession>
    <name>A0A1H6E6X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92919">
        <property type="protein sequence ID" value="SEG92919"/>
        <property type="gene ID" value="SAMN04489712_13613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="13721" checksum="E509A6B6A6FB4B36" modified="2017-01-18" version="1">MQDGDGRLAAVTRLQADYARYVDGGEAEAWSALYGSRGVLTISDGRRIGGREELTAFAARAPQGVHLQGVPGIEERPDGDIDSVAPFVFFNAETGAIVAGTYLDRMTWEEGRLVFARRHIDIKRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E746</accession>
    <name>A0A1H6E746_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketosteroid 9alpha-monooxygenase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93638">
        <property type="protein sequence ID" value="SEG93638"/>
        <property type="gene ID" value="SAMN04489712_1401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KshA_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="25508" checksum="2492BC1D90E16998" modified="2017-01-18" version="1" fragment="single">CREIVDNVVDMAHFFYVHYSFPTYFKNVFEGHIASQYMNGRSRPDVDLGTHYSGEERVSVSQASYYGPSYMINPMRSTGGQGTLESILINCHYPVSPTSFVLQWGVMVKRPAGVSMQEAEQYAQGFAAGVEKGFLQDVQIWRNKAKIDNPLLCEEDGPVYQLRRWYEQFYVDVEDVTPQMTQRFECEIDTERAKEFWHKQVEENLAAGRTVGLEPETTQAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7L6</accession>
    <name>A0A1H6E7L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93139">
        <property type="protein sequence ID" value="SEG93139"/>
        <property type="gene ID" value="SAMN04489712_13724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="153" mass="16409" checksum="51A8D2F83D655825" modified="2017-01-18" version="1">MITAGLLAGAGVRFVEALRFPAEDDSPDAKVHVREVRAYLREVLDGAGVDLDDVDLMASEIVTNAVLHTASGRPGGRVWAAVIATDEVIRVEITDQGGTAGEPRIPAYSVLGGRGLLIVQELSARWDWARNGEGFTTVWFEVPRTGGAGEWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7S3</accession>
    <name>A0A1H6E7S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93311">
        <property type="protein sequence ID" value="SEG93311"/>
        <property type="gene ID" value="SAMN04489712_13816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="128"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="28020" checksum="6994DD4CEBC73A4F" modified="2017-01-18" version="1">MVEASELQARLEQNLAEHSCHLHRHMAGATVIATDDLLIADSGTGDDTFNMVAAARFAPDTAPARVAETVERLAATGRPFSWWVGPASTPADLGALLAAAGLPEAGDENGMWRDLTEGTLPRPQDTGLVIRRVTTPAQLADYAAVLAANWDPPAATVRRFYADAAELALAPGCPARYLVGYIGERPVCTAEVFLHAGVAGIYNVSTLATDRRRGHGTAITLAALHLAHDEGHPIVVLQASPEGEPLYRSLGFAACGRFTEYAITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8D6</accession>
    <name>A0A1H6E8D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93992">
        <property type="protein sequence ID" value="SEG93992"/>
        <property type="gene ID" value="SAMN04489712_14220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="1">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="47" mass="5213" checksum="C4295A329A8FF7E4" modified="2017-01-18" version="1">MMVVFAAIAVATATATAWSDAAMIVPWTLYQRYGDLGVLERQSPWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAI4</accession>
    <name>A0A1H6EAI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxy-6-oxonona-2,4-dienedioate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93944">
        <property type="protein sequence ID" value="SEG93944"/>
        <property type="gene ID" value="SAMN04489712_1423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="31954" checksum="BB8BB2A919C6605A" modified="2017-01-18" version="1">MTTELTYESTSRELATDQGLLRYHEAGDGPPLLLLHGSGPGVTGWRNFRGNLPALAEHFRCLVLEFPGFGVSDPTDQHPMVAAGGAVTRFLDGLGLHQVDVIGNSMGGIIGTQWAMAHPDRVRRLVTIGGIGQSIFGPSPGEGIKLLMEFTEDPTRERLVQWLHSMVYDPALVTEEMIAERWAQATDPDTLASARRMYGKAAMEARTKMSAASDAPPYWAMLHRLRAKTLITWGRDDRVSPVDMVLVPMRTIPDVQVHIFPNCGHWVMIEQKQAWENAVLAFLTRKDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBX8</accession>
    <name>A0A1H6EBX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_14513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94285">
        <property type="protein sequence ID" value="SEG94285"/>
        <property type="gene ID" value="SAMN04489712_14513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="50"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="179"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG94285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="481" mass="53496" checksum="6AE5C7B91CE87713" modified="2017-01-18" version="1">MFLYKTSSAAALVGAGLGGVDAGRVLELAGARDGVPFILGPDGSYDLELNRFVREMDGWGVRSALTVEAYARDLALFCRFLALRRGGRSIWEAGQEDLRAYKRVRRRAEGSFRVAASTWNRFLAALDKWVEWAIYEGLLEGEPFRKVERTVVTPRGLAVVRVNAEYEQDEESGPARFLSYEDYLTWRDVGLLGRLPDGRADRCWRGRNGQRNAVFADLLVVTGMRLSEASYLLVNELPSLVERQKVGALALAATVTKRGRARMVYVSRRVLRALHAYVGIEREELVHRRAAAGAYRVPAQWLGVVGAGRTSVTLTGGRGRLACARLAVEDRVRLARVDAAGTVGEPLLLWLGEDGLPLGRSTWQAVFRRANDRCASVGLDLEVSPHTLRHTFAVHMLGLLLRQTVRALRMEDARTLSGQQVKRMLIGDPMRRLQLLLGHRSQETIYVYLDMLDEAQEIVLAALADWDEQAEALARVKASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S2T0</accession>
    <name>A0A1H5S2T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44905">
        <property type="protein sequence ID" value="SEF44905"/>
        <property type="gene ID" value="SAMN04489712_10157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="246"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF44905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="297" mass="31392" checksum="B229A09EFFE6C3F0" modified="2017-01-18" version="1">MKIAITGASGLIGSALAHSLETDGHQVLRLVRREPQEPGEVRWNPGGDVDTAALEGVGAVVHLAGAGIGDRRWNEEYKRRIRDSRVAGTRTIATALAGLNDRPAVLVCGSAVGYYGDTGDREAGEDAPQGEGFLARLVADWEAAARPAADAGIRLVLPRTGVVLSRRGGVLGRLLPLFKLGLGGRLGGGRQWMSWISLADQVAALRFLIDGDLSGPVNLTAPQPVTNAEYTKALARAVGRPAPWVAPKLPLRLAMGGFADEALFVSQRVVPRRLTEAGFVFAHPELAGALQAELARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S4E7</accession>
    <name>A0A1H5S4E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45330">
        <property type="protein sequence ID" value="SEF45330"/>
        <property type="gene ID" value="SAMN04489712_10171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="44"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF45330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="341" mass="37216" checksum="40FD221A1629FF49" modified="2017-01-18" version="1">MTQPDKQPDDTDEESDAVRIAVTGSIATDHLMTFPGKFADQLIPDQLHRVSLSFLVDELEIRRGGIAANICYGMGSLGHRPILVGSVGDDFADYRSWLERHGVDTDSVHVSELRHTARFLCTTDEEHNQIASFYAGAMSEARDIELGPVADRVGGLDLVMISPNDPEAMVRHTEECRERGLAFAADISQQLARMDGAQIRGLIEGAAYLFTNEYEKALVEQKTGWSDTEILDRVQTRVTTLGPKGVVITRKGQPETHVPAAPVDRAVEPTGVGDAFRAGFLSTVAWGLSLERAAQVGNLVAAHALESPGPQEYRLEREVFLTRLTDAYGQSAADEIAPHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SPB9</accession>
    <name>A0A1H5SPB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52419">
        <property type="protein sequence ID" value="SEF52419"/>
        <property type="gene ID" value="SAMN04489712_101305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="40"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF52419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="16486" checksum="F46FD01FC8C74BD5" modified="2017-01-18" version="1">MSSSKKGGGQTPATVAAAKAKVAFTLHPYDVEHGTDNYGAAVADALGVPRERLFKTLVAAVDGELTVGVVPVSGGLDLKALAAAAGGKKAQLADPPVAERATGYVVGGISPLGQRRRLPTVIDDSVSGLDTVLVSAGRRGLQIELAPADLVRLTGAVLAPIARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SPC5</accession>
    <name>A0A1H5SPC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Predicted branched-chain amino acid permease (Azaleucine resistance)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_101280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51818">
        <property type="protein sequence ID" value="SEF51818"/>
        <property type="gene ID" value="SAMN04489712_101280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF51818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="29250" checksum="419C1F63FFFECE2C" modified="2017-01-18" version="1">MTARPGHRTSPGTATSGPGRGEGSPPPASVRPAVRDGLGVGISVGVSGLAFGAAAVTAGLSVAQACVLSLLAFTGASQFALIGVVGGGGNLVAGTLGAVLLGARNGLYGLRLAGMLRVRGWRRLLSAHVVIDETTAVATGQPDDRSARAGFYTTAVSLYLAWNLSTLAGAVGAARIGDPRTFGLDVLGPAVFLALLWPRLTAGRAEARVAVAAAVLAIAATPLLPPGVPVMLAAVAALAGLRAPARDRTADGTTGGTTGEMVGGAAGGETAAETAGDASTGSGTGDAEAAGGTAGEGRKGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SRQ9</accession>
    <name>A0A1H5SRQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="4" type="ORF">SAMN04489712_101337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53266">
        <property type="protein sequence ID" value="SEF53266"/>
        <property type="gene ID" value="SAMN04489712_101337"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF53266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="604" mass="62823" checksum="1B58F4DA14AC344B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T279</accession>
    <name>A0A1H5T279_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56875">
        <property type="protein sequence ID" value="SEF56875"/>
        <property type="gene ID" value="SAMN04489712_101453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF56875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="281" mass="29309" checksum="A1FA1E7295ED0598" modified="2017-01-18" version="1">MQQLTGRAAAVTGAGGGIGRALALRLAAEGMRLALADIDADALAETGALVAGTGAEVVTRVTDVGDEESVAAFADLAFAELGAVHLLCNNAGVYMGGRVWTRPAADFEWTLRVNLWGILHGVRAFVPRMIEQDTEGHIVNTCSVAGLFVGPGAAPYTVSKWAAFAATLTLAQELALEGAKLGVSALCPGGVTTRIHQSERVRPAALATEPGEDSAFMNEMIAATVANGIPPREVADRVVDAVRAGRFLVLTHPAYEPGLAEQAEALAAGRLPRMPDFEWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T9I4</accession>
    <name>A0A1H5T9I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_101534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59404">
        <property type="protein sequence ID" value="SEF59404"/>
        <property type="gene ID" value="SAMN04489712_101534"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="9">
        <location>
            <begin position="603"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF59404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="735" mass="79342" checksum="0768E918603CDBFE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TNT7</accession>
    <name>A0A1H5TNT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gentisate 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64444">
        <property type="protein sequence ID" value="SEF64444"/>
        <property type="gene ID" value="SAMN04489712_101692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF64444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="389" mass="42889" checksum="B62E2D7B1A9B30C2" modified="2017-01-18" version="1">MSTPVTTPASPVRLRATDAPGQPDVTPALEDLYRGFERELLVPLWTEIGDLMPAHPRSRAVPHLWRWENLRGLAERAGDLVPVGRGGERRAIALANPGLGGRPFATPTLWAAIQYLMPGEDAPEHRHTQHAFRFVVEGEGVWTVVNGDAVPMRRGDFLPQAGWNWHAHHNAADEPMAWIDGLDIPLQYACEAQFFEFGRDEIGDAERITPERSRSERLWAHPGLRPLSAGEPGPGTPLLSYKWEFTDRALTDQLSLESEGFGGTVEPGHAAVRYTNPATGADVLPTIRVEMHRIVRGAETTPVRETGSSVYQVFDGSGTVTVGDRTWSVTRGDLFVVPSWESFSARSEAGSTDSDSGALDLFRFSDSPVFEALRLNRTQHDTRTEGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TTK1</accession>
    <name>A0A1H5TTK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Act minimal PKS acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66124">
        <property type="protein sequence ID" value="SEF66124"/>
        <property type="gene ID" value="SAMN04489712_101740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF66124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="85" mass="9290" checksum="0CC0F55F1B05154D" modified="2017-01-18" version="1">MQELTVTRLMEIIRECAGEGEGLAAADDVLNVEFSDLGYDSLAMLETASRIERDYGIRLPDEQVTEATTPRAFLTLVHDAAAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TZG0</accession>
    <name>A0A1H5TZG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68149">
        <property type="protein sequence ID" value="SEF68149"/>
        <property type="gene ID" value="SAMN04489712_101806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF68149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="35379" checksum="B68E20EF29BEA0DD" modified="2017-01-18" version="1">MTTAADVLRRSPVTPNRRHIPVFVTLGLLLLTFSIGSVRYENFGTPQVFLDLFIDNAFLIVVAIGMTFVILTGGIDLSVGSVVALSGMLCAIGTSKLQLPAPLVILFVLLVGTGFGAAMGYMITAFQVQPFITTLAGMFLARGVCLTLSENQISIENGFFDAVALNSLRLPGGNRLSWGAVTALIAVAVAIYVLQWTRLGRNVYAVGGSEQSAMLMGLPAGRTKIQVYAISGFCSALGGVLFALYTLSGDPTHAVGMELDAIAAVVIGGTVLTGGSGYLIGSVLGVLVLGVIKTILSFDGTLSSWWTRIAIGVLLFGFIALQRLIGARRKSRRSAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UX27</accession>
    <name>A0A1H5UX27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose/arabinose dehydrogenase, beta-propeller fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79001">
        <property type="protein sequence ID" value="SEF79001"/>
        <property type="gene ID" value="SAMN04489712_10247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009286648" evidence="2">
        <location>
            <begin position="25"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="63"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF79001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="374" mass="39994" checksum="26A858D266AE013E" modified="2017-01-18" version="1">MPIGIRRIIALGAATTVLAGCTSASEGGSRTPPPLPAATTGGGSPATTRVAAPGEPRDLVTGLSVPWAIAFLPGGDALVTERDSARLLRVTPRGSVTEVGKVPGVVPGGEGGLMGVAVSPSYDRDRFVYLYFTAADDNRVVRFRYDGRLAAPRPIVTGIPKGANHNGGRIAFGPDKMLYIGTGEIYQRELAQDRGSLGGKILRVTPDGGPAPGNPFSSRVWTYGHRNVQGLAWDDKGRMYATEFGQDRFDEINLIERGHNYGWPDVEGVQQGRRNTRYTDPLLTWSTGEASPSGLAYASGSLWAAGLRGRRLWQVPVDADGRVGRPIAHYEGRYGRLRAVVRAPDGSLWVTTSNKDGRGDPARGDDRILVIPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UXC5</accession>
    <name>A0A1H5UXC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6458 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79091">
        <property type="protein sequence ID" value="SEF79091"/>
        <property type="gene ID" value="SAMN04489712_10251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045597">
        <property type="entry name" value="DUF6458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20059">
        <property type="entry name" value="DUF6458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6458" evidence="3">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF79091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9294" checksum="52CA6ACAF554C4E6" modified="2017-01-18" version="1">MTIGGSLALIIIGAILAYAVDFDLSGLDIRVVGVILMIGGLVGLIIGLVRLATARRRTAPPPGAAVREERYYQEPSAYDDPARRHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V1H7</accession>
    <name>A0A1H5V1H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette, subfamily B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_102103</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80538">
        <property type="protein sequence ID" value="SEF80538"/>
        <property type="gene ID" value="SAMN04489712_102103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="324"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF80538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="557" mass="57190" checksum="4EE4247008D47C73" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V1V9</accession>
    <name>A0A1H5V1V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formiminoglutamate deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80668">
        <property type="protein sequence ID" value="SEF80668"/>
        <property type="gene ID" value="SAMN04489712_102108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02022">
        <property type="entry name" value="hutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="48"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF80668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="452" mass="48018" checksum="C1F1EF44B7DCDB16" modified="2017-01-18" version="1">MRWHAELAWLGDEVAADVLIEADGERFATVRPGVPAPPDAERLPGLTLPGLANAHSHAFHRALRGRSHAERGDFWTWREQMYAVAGRLDPGSYRALARAVYAEMALAGISVVGEFHYLHHRPGGAPYDDPNAMGEALIAAAADAGIRITLLDACYLTGGIGRPLQGPQLRFGDGSAGNWQRRVDALHGAVGKNGRSHARIGAAVHSVRAVPREQIHAVAAWARDRRAPLHVHLSEQPAENEACRQAYGTSPTRLLADAGALGPLTVAVHATHLDDEDIRVLGTTMTGVCMCPTTERDLADGIGPARDLVNAGAELSLGSDQHAIIDLFEEARAVELDERLRTHRRGHWSAGALLAAATWNGHSALGWPEAGRLEPGAYADLVTVALDSVRTAGTTAEFAAESVVFAATAADVRHVVVSGRPIVRDGRHLLVPDVPAALHTAITELTTAGPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VB91</accession>
    <name>A0A1H5VB91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4031 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84645">
        <property type="protein sequence ID" value="SEF84645"/>
        <property type="gene ID" value="SAMN04489712_102251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025109">
        <property type="entry name" value="DUF4031"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13223">
        <property type="entry name" value="DUF4031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4031" evidence="2">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF84645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="101" mass="11375" checksum="A507940B1F5399CE" modified="2017-01-18" version="1">MILIDPPLWPFRGRVWSHMVSDSSYEELHVFAARLGVPPRAFDRDHYDVPSELYQRAIDLGASPVGCQELLSRLTRAGLRRPKRRPTRPPGTAAMNPVPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VIQ4</accession>
    <name>A0A1H5VIQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR C-terminal helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87100">
        <property type="protein sequence ID" value="SEF87100"/>
        <property type="gene ID" value="SAMN04489712_102337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="334"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF87100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="44629" checksum="0793DF913695AB81" modified="2017-01-18" version="1">MGVSAPGPGDWPLARIPAELAAPLRPHLEAAAEEMVREIQALVPEYSRPLDSRYGRRMKWAVQETVRHFVDAMGAADFDWSELTGIYAGIGAHEAGNGRSLDRLQTAIRVSGQVACRRFIKDARRLDWPLDLLGQITESLFVFLEKLAGAAAQGYADAQEQVVTERERSRWRLRDLLVVDPPASREAVAELARSARWEPPRTIGVVAVRPPLGHPPPVMPPSILADWHGPAPYLVVPDPDGPGQDRVIASLVRDCAAAVGPTVPLTRGALSLRWARHALGLVERGVICEKAPVRCLDHIPTLVTAMSEELINVALGERLAPLMELAPHRREPLALTLLTYMENRDNAVAAAERLLVHEQTVRYRIRRLEEMFGDALSDPDRRIEMLLLLHTWVRFGGTTAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W268</accession>
    <name>A0A1H5W268_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ascorbate metabolism protein UlaG, beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93550">
        <property type="protein sequence ID" value="SEF93550"/>
        <property type="gene ID" value="SAMN04489712_102561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF93550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="214" mass="23141" checksum="46A034BEE6FF213B" modified="2017-01-18" version="1">MKLTKLGHACVRLTKDDRTLVIDPGGLTPEQDALEGADAVLITHEHFDHFDENRLRQAMAANPRLELYASHVVADKLADLGGRVRAAGHGDALTIAGFDVHVYGEDHEILDPDVPPIPNTGFLVDGEVFHPGDALTVPSEPVPTLCLPGTAPWMKVSEMYSYVKEVAPERAYVIHDGILNEVGISVMETHVGNAAAKAGKEYRRLKPGESVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W429</accession>
    <name>A0A1H5W429_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93996">
        <property type="protein sequence ID" value="SEF93996"/>
        <property type="gene ID" value="SAMN04489712_102574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="64"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="213"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF93996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="309" mass="33973" checksum="EB6BDA6B1EF01532" modified="2017-01-18" version="1">MPSSPNHVLEFPGGYTRSVGPVIGRFLSELRDGRLVGVRTAGGRVLVPPTEYDPDTGAAVTDEWVEVGPAGTVQSWSWVPNPRPDHPLDRPFAWALIKPDGADTALLHALDMGEFEAGAEPPRFLKTGLRVRPKWRAERGGGIGDIECFRPEVTMINAPTRLEYTLDPGRALSRFLESISQGRILGHRCPVCDSVIVPMKGMCSRDGVPTTEEVEVADTGTVTTFAVNNIPDPRAPEVPFVSAYILLDGADLTMLALVAGIPADQVRIGMRVKAAWRPREEWGPTMNNIRWFEPLDEPDVPFERIKDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W6Y8</accession>
    <name>A0A1H5W6Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95180">
        <property type="protein sequence ID" value="SEF95180"/>
        <property type="gene ID" value="SAMN04489712_102612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009287947" evidence="3">
        <location>
            <begin position="26"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="107"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF95180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="26036" checksum="0ADCE9648CCBE924" modified="2017-01-18" version="1">MSIPLKAACSAATLALVLVPGIGEARVAAHTGAVPQRPDEAAEGQAGTAAMPHRFGRPEGKQGAPNGPAFRQVLYGRANGALLPGYALAARQRLALQRRMRLIAQWQGRADRAVRYALRQQGKPYQWGATGPFSYDCSGLVQRAWRRAGVAIPRVTYDQYRGIRKKVPRRRLRPGDLVLFDGLRHVGMYVGRNHFVHAPRAGRPIMTQPLRGYYGRRYVGAVRPAWPRLPRIPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WAB5</accession>
    <name>A0A1H5WAB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, DUF58 family, contains vWF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96499">
        <property type="protein sequence ID" value="SEF96499"/>
        <property type="gene ID" value="SAMN04489712_102648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="186"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF96499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="430" mass="46587" checksum="1B778B2C6F04679D" modified="2017-01-18" version="1">MALTGRLGLLALLGAFVPLLLPGWGTLLVVWGVLLLGVAVDLALAGNVRRLALHRAGDTNVRLGETATVSLVVENLGRRRVRARLRDAWPPSAAAAPRVTRIDVAAGERQRVVTTLTPTRRGDRRAVTVTIRSVGPLGLAARQLNRPAPWTLRVLPGFPSRRHLPGKLAKLRELTGRHVALIRGQGTEFDSLREYVDGDDVRSIDWRATARRADVVVRTWRPERDRRIYLVLDTGRTSAGRVGDIPRLDCSMDAALLLGALASRAGDRVDLLAYDRRVRARVEGVGGRGILSAMVQAMAPLEPELIESDAAGMVSTIMSRVRQRCLVVLLTELNPAAIEEGLLPLLPQLTARHLVMVAAVADPRVAEMARARGDLAAVYDAAAAERARADRRRLTAELRRYGVEVVDAAPDDLAPALADAYLALKAAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WAT0</accession>
    <name>A0A1H5WAT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized membrane protein YckC, RDD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96574">
        <property type="protein sequence ID" value="SEF96574"/>
        <property type="gene ID" value="SAMN04489712_102650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF96574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="347" mass="37192" checksum="F0DFE54E6DE939E4" modified="2017-01-18" version="1">MAELVTGEAVALDIRVARLASRACALLLDLIFQIMMLNIVLYLAAATEAIADDAWGVGLGIVATAGVLVGYPCVFETLSRGRTLGKLALGLRVVADDGGPVRFRQAFVRGLAGVVEIWLLSGAPALITSLFNRRGKRLGDVFAGTVVIQERVPATAIFGPVAVMPPQLAGWARSLELSQIPDDLALTARQYLARFWELLPEVRDAMGQRIADQVLAVTSPPPPPGVRPEILLSAVFAERRHREEWRLEQRRQRRMRMWWGPGRPVPASPAAMHVAGPPPVPAGPQGPPMPPPFSPPVPGRPAFLPPTEYGSGPYAQVLAPPATGPQPYAPDMRAPGSGAPPLRNDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WB81</accession>
    <name>A0A1H5WB81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96608">
        <property type="protein sequence ID" value="SEF96608"/>
        <property type="gene ID" value="SAMN04489712_102651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF96608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="20378" checksum="C8A6098040804ABD" modified="2017-01-18" version="1">MIRMGRPRGFDEAEAVRSAATLFARRGYDGISVDDLVSHLGVHRNSLYKTFGSKRGLYLRALRWHLEHQVAPLLDAIRQAPDAATALHRSLDAQAAGADIGLLLMAVADRAPSDPDVAAEVERALADFDQAITQALTGGSPPPSPQAPAGDRPPPAEALAPALTATVLGLHLRGRVGAPAAEAVAALAGRLDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XA94</accession>
    <name>A0A1H5XA94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08659">
        <property type="protein sequence ID" value="SEG08659"/>
        <property type="gene ID" value="SAMN04489712_103163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="120"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG08659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="35792" checksum="1FAD7F8C9DD5E978" modified="2017-01-18" version="1">MVAPRVRASKEKAGPREGRLRAAGRMALRRLAVAVPLLLAVSGVVFALGAASPFDPVYQYYGTRIFTAAEADVARTRAELGLDEPVWQQYGHWLNGVLGGDWGLSRSYGQPVSDVVAERLPWTLLLAGTGLALAVLIALTLGVASAWRQGGWIDRCTVTMAHTLEGLPTFLLGLGAIAVFAVAMPLLPAGGVSEATGTATVASTIRHLALPALVLAVAQLPWLILTVRQQLLVALSEDHVTAARSRGLPERTVVLRHGLPGALLPFVTTVGTRLPELVTGVVLVEEVFSWPGVAGAMVRAGLNVDFPLLVALTLLATGAVLVGNLCADIAVLLIDPRASANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XB74</accession>
    <name>A0A1H5XB74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mce-associated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08989">
        <property type="protein sequence ID" value="SEG08989"/>
        <property type="gene ID" value="SAMN04489712_103176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG08989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="309" mass="32090" checksum="17EAF2CAADB3DFD4" modified="2017-01-18" version="1">MTPLEETVAAETRTEEPPGIEGQDADDPEAVTPKAEDTKAEDTKAAGTKAAEPGAEDPKTAKPKAADSTADEPKTAASDAADSTATDSTADEPKTGKTGKAEADGEGRGRPGAFRHRVLSGAALTRAAVLIALVASVITAGLQWHQADQAEQREADRRAVRARAGEFGQALLSYDHRNLQAARNRVLSLASDDFAKTYDAAFTGGLEGVIAKLKADATATVRAVYLGDIEGSTARAIVVMDSEVHSSAGTRRVLGSHLDMRLTRTGERWRVTEVTSIGAADETMTDGEGGQRQGDGAPLPAPSASPSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XJ14</accession>
    <name>A0A1H5XJ14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11748">
        <property type="protein sequence ID" value="SEG11748"/>
        <property type="gene ID" value="SAMN04489712_103279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016499">
        <property type="entry name" value="NucleicA-bd_Rv2694c_prd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006910">
        <property type="entry name" value="NA_bind_Rv2694c_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG11748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="15017" checksum="42AC8846A5925B1A" modified="2017-01-18" version="1">MDEVPAESAVGAGGAPGPARERGLRRFLRRLASSRDELEAEELQQSTGQEGATPIAGCGERSRACVAGTLRTVTLRPRGGAPALEAELYDGTDVISLVWLGRRKIAGIEPGRRLRAEGLVSVQDGRKTMFNPRYELRGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XQN4</accession>
    <name>A0A1H5XQN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14061">
        <property type="protein sequence ID" value="SEG14061"/>
        <property type="gene ID" value="SAMN04489712_103365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG14061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="13166" checksum="A4ABA9AF7DF53AF3" modified="2017-01-18" version="1">MTAPAYNTMAWFQVGTDDPDAARRFYGRLFGWSFAADPGGDGRYDLVSYPGAELPSGGVFDTGGREPGHAIFCVVVEDVAAICAETELAGGQVVVPPTTRPSGLVFADLRDPAGNLFGVFSPPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XUK6</accession>
    <name>A0A1H5XUK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15424">
        <property type="protein sequence ID" value="SEG15424"/>
        <property type="gene ID" value="SAMN04489712_103417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289868" description="Lipoprotein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="5">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002854-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG15424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="28508" checksum="314A1890EE194C1B" modified="2017-01-18" version="1">MLRKLTVAIASAGLLFGLTACGSSDSGDTGSDDVLTVGASPAPHAEILGYVKDNLAAKAGLKLEIKEFSDYVQPNLALNDGQLDANFFQHKPYMDDFAQSKGLKLTFVAPVHLEPLGAYSKKVKTLAELPQGATVAIPNDATNGARALKLLADNGLITLKEGAGTNATEKDVAANAKGLKFRPLEAAQLPRSLQDVDAAVINGNFALEGGLTPAKDALVLEKADGNPYANGVVTKTGQENDPQVRKLVELLQGAEVKKFIQDKYQGSVLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y0H4</accession>
    <name>A0A1H5Y0H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall assembly regulator SMI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17438">
        <property type="protein sequence ID" value="SEG17438"/>
        <property type="gene ID" value="SAMN04489712_103496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="2">
        <location>
            <begin position="185"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG17438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="528" mass="57101" checksum="E32E30745A319265" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YJ98</accession>
    <name>A0A1H5YJ98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24181">
        <property type="protein sequence ID" value="SEG24181"/>
        <property type="gene ID" value="SAMN04489712_10446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG24181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="111" mass="11790" checksum="3D48F11ADBC9E723" modified="2017-01-18" version="1">MTRPTTWRKSTHSGGNGNCVEVARLNAAVWRKSSYSGNNGGECVEVARLNAAVWHKSSHSGNTGGDCVEAARLDAVIGLRDSKNPDAEHLTVPAEAFAALLAHLKHDKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YQ33</accession>
    <name>A0A1H5YQ33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26223">
        <property type="protein sequence ID" value="SEG26223"/>
        <property type="gene ID" value="SAMN04489712_104125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="74" mass="8195" checksum="8E62934BC89B571D" modified="2017-01-18" version="1">MRRLRMLPYAAAAVVSSFWADRVARTRRDLREDSARGSNVVETIIIVAGFAGLAFTIYLAVSGKVQNWINKIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXL7</accession>
    <name>A0A1H5YXL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28550">
        <property type="protein sequence ID" value="SEG28550"/>
        <property type="gene ID" value="SAMN04489712_104227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291019" evidence="1">
        <location>
            <begin position="31"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG28550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="380" mass="39011" checksum="1E1CC28AF50A1516" modified="2017-01-18" version="1">MSRSRMPRIAACLAAVGGVTVALVPGSGQAAQGTPTVRVVAEGLNSPRGVTVLGDGTVLVAEAGTGGRGPCTKSTGASETRKCFGNTGSIYRVRGKHQGRVVRNLPSISDPAGREAAGPVDVVVSGDGYLVLSGAALNSAKRAQFGAQARRMGTLYHVGGRWHGSVIADLVEHETRLNPDGVLPPTGPGKEPLHSNPWRFVAAGGDWLVTDAGANDLIRTARGGPAHTELVFPHSELRARGSRAPELAESVPTGIVRGPDGAYYVGELGGRKPGAARIWRIVPGHRPQVFVSGMTSLTDLALDGRGGLVALSMGEAAGSGGAAKPGALYRIDLKTRARSEIPTGGRLRMATGMGIGREGEIYVANNGIGNGAGQLVRVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z332</accession>
    <name>A0A1H5Z332_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30721">
        <property type="protein sequence ID" value="SEG30721"/>
        <property type="gene ID" value="SAMN04489712_104321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG30721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="34698" checksum="30FB321C5A45616E" modified="2017-01-18" version="1">MRVVPRRGKRRADTPAKDAKGRPSAADRPPVPPPPDSPEASENAPGSPKASGKGPGSPEVAGKGSGVSGKGSGSRNVPEKAPDSPSASGKGLDSPGASGKGPGSPGASGRGPGAPGTSGKESDSPDATGKGSGGDTATRPLDRRAAERARRADALRRVQEQRRARAGRGRHKAARSRPALLALVITLGVLIAAVAVTGTLIATSREEKPMPLAAPLHVYPVTQVVSGACPAGTQGITGQTVSGPACYQLSSGIAIRRVTELRVQQGQAAGTHDVAISLSGTDRQAFAGITRQTVGRTVAFVVRDQLVTAPRVDMPITDGKVVVTGRFTKSDADRLVRTLKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZAV4</accession>
    <name>A0A1H5ZAV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ORF">SAMN04489712_104425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32767">
        <property type="protein sequence ID" value="SEG32767"/>
        <property type="gene ID" value="SAMN04489712_104425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG32767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="153" mass="16196" checksum="5A4A4B0B8B5BF304" modified="2017-01-18" version="1">MADVTEGTPLKVHDLRPAPGANKRKVRKGRGEASKGKTAGRGTKGTKARSTVPVGFEGGQMPLIRRVPKLKGFKNPFRVEYQVVNLDKLTELYPQGGEVTPEDLVAKGAVRKNQPVKVLGNGEISVAVQVRAHAFSASAKEKIAAAGGSTDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZK9</accession>
    <name>A0A1H5ZZK9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41532">
        <property type="protein sequence ID" value="SEG41532"/>
        <property type="gene ID" value="SAMN04489712_10584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="94"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG41532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="35653" checksum="3B9171C4121BF5BE" modified="2017-01-18" version="1">MAATGDLPEDADHWGLELKWDGVRVISSVTAAGVRATGRRGADVTGRYPELSGLADLVQGHDVVLDGEVVAFRNGRPSFEWLQRRMHVSRPDPMLVRRVPVRYVVFDLLHLDGRALYDVPYTRRRELLDALDLAAAGPVEAPPYLHAADTDQVKELIEYTWEQRLEGMVAKRLDSPYRPGRRVDFWRKVKNFQTQEVVICGWKPGQGRREGGVGSLLLGVHDDKGALCFAGHVGTGFTDHALDDIYERLWPLRRPTSPYDDVVPREHARDAQWVEPVLVGEVSHSAWTREGRLRTPSWRGLRDDKDPREVTYDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1E8</accession>
    <name>A0A1H6A1E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein YbgA, DUF1722 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42172">
        <property type="protein sequence ID" value="SEG42172"/>
        <property type="gene ID" value="SAMN04489712_105121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013560">
        <property type="entry name" value="DUF1722"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017087">
        <property type="entry name" value="UCP037004"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08349">
        <property type="entry name" value="DUF1722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037004">
        <property type="entry name" value="UCP037004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1722" evidence="1">
        <location>
            <begin position="190"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG42172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="316" mass="35571" checksum="1BE936DE834DFCCE" modified="2017-01-18" version="1">MEHVRPLVAVSSCLLGAPVRYNGGHSRDRFLAEELDRYVDWRPVCPEIEIGLGAPRPTLRLVTDSGEVRLVTREGDADHTEAMRALADRRAEELAGVDGWVLKARSPSCGLRGIPRYRKGQPADRRGRGVFAERLTERLPLLPVEEEGRLHDDVLRAHFVERIFARARLRALLAGDWRPRDLVAFHTRHKLQLLAHDPDRYRRLGRVVAEAGSAPRTRVEAGYAELFAAALAVRPRRGRHVNALLHVFGPMSERLDDARRHDIVTAIEEYRQGTVPLGVPMALLRHHARGEGCAYLLAQTYFEPYPRGLVPSVTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2H2</accession>
    <name>A0A1H6A2H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42404">
        <property type="protein sequence ID" value="SEG42404"/>
        <property type="gene ID" value="SAMN04489712_105136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="47"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG42404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="220" mass="22772" checksum="C1157AE4263FC382" modified="2017-01-18" version="1">MQKFDTPAPISAVLDIPAGRVRFIAADRADTVVEVLPANAAKGRDVKAAEQTKVEYADGVLRIETSAKNQYLGPSGSIEVTVRLPAGSRVEGKAACTELRVVGRLGDVVFEGAYHQIKLDEAASVRLTAIDGDVEVGRLGGPAEISTHRGDIRIAEAVRGKVVLRTRSGDISVGAAAGVSASLDAGTGYGRITNALKNDGTAGLDIHATTSQGDIAARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABQ5</accession>
    <name>A0A1H6ABQ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_105304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FBPase class 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45475">
        <property type="protein sequence ID" value="SEG45475"/>
        <property type="gene ID" value="SAMN04489712_105304"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG45475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="36667" checksum="79D64200876A7A0A" modified="2017-01-18" version="1">MSAMSARSDTTPVPSPLATEPAAPDRNLAMELVRVTEAAAMAAARWVGRGDKNGADGAAVNAMRQLINTVSMRGVVVIGEGEKDNAPMLYNGEEVGDGGGPECDVAVDPIDGTRLTAMGMPNAIAVIAVAARGSMYDPSAVFYMEKLVTGPEAADVVDIQRPIGDNIRAVAKAKGSSVEDVTVVILDRPRHEAIVKEIREAGARIKFITDGDVAGAIMAAREGTGVDMLLGIGGTPEGIIAACAVKAMGGVIQGRLWPQDEAERRKALDAGHDLSRVLTTDDLVTSDDVFFAATGITDGELVGGVRYRKGTAVTHSLVMRSRSGTIRKVESEHQLGKLRAYSAINFDQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AEF9</accession>
    <name>A0A1H6AEF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysophospholipase L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46136">
        <property type="protein sequence ID" value="SEG46136"/>
        <property type="gene ID" value="SAMN04489712_105346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="71"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG46136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="344" mass="35289" checksum="5338F93E1C9ECFF9" modified="2017-01-18" version="1">MLRALTARRIATAAVYGGGGITALGGLTFGLVVLEARLARRIIQATPNGDPPVADGLYGAALPGEPVSFAVLGDSTAAGLGVHRPDETPAALLATGLSAIAGRPVRLTNVARSGSRSEVLDGQVTQALTARPDIAVIMIGANDVTARIPPAVSVRHLDDAVRRLLAAGCQVVVGTCPDLGSVEPLMQPLRWIAQRASRQLAAAQTIAVVERGARSVSLGDLLGREFAAEPGEMFSKDRYHPSARGYAAAAMALLPSMAAALGLEPEEPELMPDPSRGVGVLPVYLAAAEAAEEPGMEVAGTRVAGRERGPRGRWATLLRRRGAPADDEADGPAAEVAPGPTGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJL9</accession>
    <name>A0A1H6AJL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48963">
        <property type="protein sequence ID" value="SEG48963"/>
        <property type="gene ID" value="SAMN04489712_105507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG48963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15979" checksum="73F4AD1CC5C865D1" modified="2017-01-18" version="1">MPTGRFVEVVRFPVENVSPEAQVNVREVPAYLREALDGAGADLDDVDLMAAEIVTNAVRHTASGRPGGQVWAAVIATDEQVRVEVIDQSEARSEPWIPPYPVLSGRGLLIVQELAARWDWSRDRNGYTTVWFQVPRTGGAAGWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AKM8</accession>
    <name>A0A1H6AKM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48637">
        <property type="protein sequence ID" value="SEG48637"/>
        <property type="gene ID" value="SAMN04489712_105486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG48637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="554" mass="60477" checksum="C9ED9CF19075EC2F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXX6</accession>
    <name>A0A1H6AXX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron complex transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53242">
        <property type="protein sequence ID" value="SEG53242"/>
        <property type="gene ID" value="SAMN04489712_10681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="65"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG53242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="36316" checksum="BBEAF6F973B5B813" modified="2017-01-18" version="1">MPHPPTAVPMSRRGLLALGATAFGVLLTGCGTGEEGSSSASPAKGGPWSFTDDRKTPVTADAVPSRVVAFTGTAAALIDFGLDRQIVGVFGETTRKDGTLEPQAGDLDAGKVTVIGNAWGEFNIEKYAALRPDLLVTHMYDPGALWYVPDESKDKILRLAPSVAIGTARVLLTQPIERYAELAASLGADLNAPKVAQAKARFEKAAEAVRKAVERNPGLKVLAASASPDLLYVSNPKVNTDLVYFTELGVPVVVPDKPGEGGHFEELSWENADKYDADVILLDNRGTALQPADLTAKPAWKELPAVKAGQIAPWDPVPRFSYAGAAPLLENLAQTIEKARKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYZ6</accession>
    <name>A0A1H6AYZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-1,3-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53530">
        <property type="protein sequence ID" value="SEG53530"/>
        <property type="gene ID" value="SAMN04489712_10698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="entry name" value="PTHR38165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293159" evidence="1">
        <location>
            <begin position="31"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="28"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG53530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="438" mass="47213" checksum="685829601B8819AC" modified="2017-01-18" version="1">MKTRNLAAALSAFTLLAAGAMAGAPRPAEAAACGTANAALNRPATASSVESGAFPASAAVDGNTGTRWSSAFSDPQWLRVDLGAAKSICRVVLRWEAAYSRAFQIQVSDDGSAWTSIYTTSTATGGTQTLDVTGTGRYLRMYGTARGTGYGHSLWEFAVHTTEGSSDPFWGDTSTIPPARNVLMVKVLNRTNGQYSDDQVFWSYNGQVHSIAEQPYFDMPANTAGRMYFHLGSPTSRYNDFIEFTVGPGVFNGNTTRVDGFGLKLAMRLHAHDGYDVAVGEEQNIFQESRAATFQRFIDEVPAEFDHLAQVEAPYRIPSPGNSSAFRPGGAYANYFTAYAASAGVSATTAEVTGCAGPLAERPGMCAALNRHVAGLPESQWSDPSQFYRAAPANYYARFWHDHAINKLAYGFPYDDYADQSSFISHGNPQYLLVAVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B0J2</accession>
    <name>A0A1H6B0J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53626">
        <property type="protein sequence ID" value="SEG53626"/>
        <property type="gene ID" value="SAMN04489712_106105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG53626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="34440" checksum="6F0161D78BD249B8" modified="2017-01-18" version="1">MDLKAVRTFVAVADAGWFQEAAAELSLTQQAVSKRVAALERDLGVRLFTRTPRGARLTIDGQAFLPHARDLLRAAERAAASVRPGRRALRVDVIGRRLAPADLLRGFRRARPEIELDVVTLFDVDAAIAAVRSGTIDASFRAVPLPARLPDGMEAARVFDEPLQLLTGPAHEFAAARAVTPARLAGHRIWMPGLVAGTEWAGFYDDLAAAFGLTIEVTGPDFGAEPLLDTIADSPALATLVGERTRLVWPADQDLRRIPLRDPTPVYPHSLIWRGDNPHAALTALRDHLGSLRDDHRDVGTWTPQWARRPQVTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B1B1</accession>
    <name>A0A1H6B1B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_106154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54390">
        <property type="protein sequence ID" value="SEG54390"/>
        <property type="gene ID" value="SAMN04489712_106154"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG54390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28419" checksum="D8B576A37027820F" modified="2017-01-18" version="1">MSRRLLTALLAPVAVLMAVPLVYIVSLSLRSRDDVLNGGLLPSEVFWRNWPDTFGAIDLPRHLANSWVVAAGAVALTLAIAVPAAHYTARARRSGERLLSLVLASYCAPPVVAVLPLFYLLRTTGLNNTLAGLVLVTGLANVPVAVWLLDGFVRRVPQEIEEAAWLDGLGGWGVLRHVIAPLIAPGIVASGLICFFLGYNELLFALSFAQETSVQTLPVALSLFQGDRNIQFGRQAVASIVGVAPVYVLALLAQRRLVAGLSAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6Z8</accession>
    <name>A0A1H6B6Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA thioesterase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56619">
        <property type="protein sequence ID" value="SEG56619"/>
        <property type="gene ID" value="SAMN04489712_106325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG56619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="30897" checksum="52A587756121C24E" modified="2017-01-18" version="1">MPDEPTDQLPPALARMLALQPLDGDVFVADSPALGRERLFGGQVAAQSLRAACLTVDAGRPPHSLHAYFIRPGLPGEPLRLEVGRTRDGRTFSTRHVTAAQGGKPIFEMVASFHDPEPGHDWQPPPPAPVPGPQGLEPPRLPRHPPAFDIRLVRRPDPGGSLLPHPFWIRVREPLGDDPALHACLITYLSDMAVVSSAVAPGSPRRSLAMAVSLDHALWFHRPARVDRWLLYSVDPVTNFGARGLARGTLHTADGVLVASIAQEALLRPAGEAGLTVLRDRRPGPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B749</accession>
    <name>A0A1H6B749_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56354">
        <property type="protein sequence ID" value="SEG56354"/>
        <property type="gene ID" value="SAMN04489712_106306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_ligase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="632" mass="68553" checksum="22CE2F9EAAA671A2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B7G5</accession>
    <name>A0A1H6B7G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_106315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56474">
        <property type="protein sequence ID" value="SEG56474"/>
        <property type="gene ID" value="SAMN04489712_106315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG56474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="490" mass="50457" checksum="419E978B23C40FE5" modified="2017-01-18" version="1">MAVDAGEQDVAQRLGRTLSTPKIVFLVVAAAAPLVAMAGTVPLSMGAGNGAGVPGAYLVATVTLLCFSVGYAAMARRVTDGGGFYTYLARGLGRPVAAAGAVFALVAYNALVAALAGGIGYFLTDGAEAPGPWWAWSAAAIAIMAVLGFRSVDLSAKLLAVLLTCEVAVLLVFDVAVLADRGLDAFVAASFDPGTVLAGAPGVAFMFAFGSFAGFEGAALYAEETRDPARAVPRATYTAVLVIGLFYTLTSWLTVGALGAERAQPVADAEEGDLLFNLTREFLGTGVEAVFGLLVITSVFASLLSSHNAAGRYLFSLARDGLAPARLGRVHPRHRSPYAASLAQTAFTALVVAAFAIAGLDPYRNLVTIMSGLSTLGIVLLQAFAAIAVVVYFRRHRAGTVLRTLAAPLAGCAGLLTATALLLANFRTLAHSDALVILALPYLVMALALAAALYAARLRHADPRRYARIGHPASATAATREGETDDVHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B7Q1</accession>
    <name>A0A1H6B7Q1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2510 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56838">
        <property type="protein sequence ID" value="SEG56838"/>
        <property type="gene ID" value="SAMN04489712_106340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2510" evidence="3">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG56838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="405" mass="41750" checksum="D8F75970F7217759" modified="2017-01-18" version="1">MSGQIPAGWYHDPYGTPGLLRYWDGGQWTQATQPSDEWNDAEPTQGGAAPADAPVPSGPPESSPAPSGPPASSGSPALSGPPVPAGFSPDAGAGQPGGSTPPPWMPPADGRPNWNWDGPPAGPATPQPWQASKGPQTPPPWQSPQGPGTPQPWQTGPPQPAGSNTGLLWALGGGGVVVIVLIVLVALFATGVLGGGPEPSSATAAPAPTATVPSVNPTGRSPVTGTITDDTAGVSYAQLGGGWQPQQIDPNSPFARERGFSRGQIAVVQNDYNGSGGQYLASVYSGRLPESVGYDGPEDLQTAISDFARSIETEPEPTGSYPSHTREDLESASRTIGDHKAHLVRFRLSFPQAASRGWNFRSETVAFVLIDQGSGQRPSVVWITVPDSHGNGGDLDLLLESIKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BDK0</accession>
    <name>A0A1H6BDK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58903">
        <property type="protein sequence ID" value="SEG58903"/>
        <property type="gene ID" value="SAMN04489712_10731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG58903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="168" mass="17742" checksum="9635E2DE30031B5C" modified="2017-01-18" version="1">MREEAGCIGTGSVGTTGVMHEIEMRSAAFNDHAMIPREYSHQAGDVSPPLEWTGVPDEAVELVLTCEDPDAPVGTFVHWLVAGIPPETGGVDAGEQVTDAVPGRNDYGTAGYGGPHPPPGDDPHRYFFRLTALAEPSGLRPGFTVDDLREAVEEKVVGTGTLVGTFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BDS0</accession>
    <name>A0A1H6BDS0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SAMN04489712_10736</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58961">
        <property type="protein sequence ID" value="SEG58961"/>
        <property type="gene ID" value="SAMN04489712_10736"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="39"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="195"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SEG58961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="344" mass="38958" checksum="FCB971D646379A92" modified="2017-01-18" version="1">MKRTVTRLADGRELIYFDRRDDAVRDAVDTRPPDGPPAASELRHDPLLDEWVTIAAHRQRRTFLPGDDACPLCPSAPGRPTEIPAADYEVAVLENRFPAFRPEATGGRCEVVCFSSDHRVSFADLPPAQVRTVVEAWADRTAELSATPGVEQVFCFENRGEEIGVTLHHPHGQIYAYPFVPPRTRQMLRAVRRHAERTGGDLFAELLAAERREGARVVVANELWTAFVPHAARWPFEVHLYPHRRVPDIPALDEAERDAFARLYLDVLDRFDRLFDRPAPYVSAWHQAPVREGRDLAWLHLRLFSIRRAADRLKYLAGSEAAMGAFLNDVRPEEAARLLRAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BEB1</accession>
    <name>A0A1H6BEB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipoprotein-anchoring transpeptidase ErfK/SrfK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58992">
        <property type="protein sequence ID" value="SEG58992"/>
        <property type="gene ID" value="SAMN04489712_10738"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293667" evidence="5">
        <location>
            <begin position="35"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="54"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="253"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG58992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="44218" checksum="9E8BE12DDE7BEC0D" modified="2017-01-18" version="1">MVNLPHPSRPSSAAVALTALLPLAGCSGDGQGRAAERPAPPPARLTITPVHGTDDARPDRPITVQAAGGTIRQVTVSIENGNDGKAGKAGKVEGALNPARTRWTSRWTLAPDTDYQVTAIAAGPDGRTTTLTSAFSTLKPKETIRVSAAAPFDEETVGVGMPIILDFDRPVYNKAEVERALQVTASTPVEGAWRWVGRQQVVYRTKKYWPARTDVTVTARMRGVRAAKDVYGTRDLKLRFRVGDEQVSTASARTHTMTVKRNDKTVRRIPVSMGKATKRAYTTTNGVHLTMEKAYHVVMDSATVGIPKGHPDYYKLDVYYAVRISNSGEFTHSAPWSVGSQGTANVSHGCVNMSPKNAAWFYRFSRRGDIYKITGTDRELEWNNGWGYWQLSWNEWRKGSALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKW0</accession>
    <name>A0A1H6BKW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61361">
        <property type="protein sequence ID" value="SEG61361"/>
        <property type="gene ID" value="SAMN04489712_107207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG61361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="154" mass="16417" checksum="B974CDF716267B30" modified="2017-01-18" version="1">MRLSARVDYALRAAAELAVAGSSPVTAVQLAEAQQIPPKFLENILGQLRRSGLVRSQRGPDGGYWLAKPAGEISLADIIRAIDGPLLGVRGERPEHVGYQGPARSLQEVWIALRASERGILESVTLGHIAAGELPEPVAELTKDPAAWQSPSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNH9</accession>
    <name>A0A1H6BNH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="10" type="ORF">SAMN04489712_107243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61776">
        <property type="protein sequence ID" value="SEG61776"/>
        <property type="gene ID" value="SAMN04489712_107243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="106"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="115"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="165"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="219"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG61776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="613" mass="65773" checksum="A7F629E3D8B8A532" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1D6</accession>
    <name>A0A1H6C1D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66673">
        <property type="protein sequence ID" value="SEG66673"/>
        <property type="gene ID" value="SAMN04489712_108213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="82" mass="8484" checksum="D21FC4F2A3AF7E0F" modified="2017-01-18" version="1">MIGSLTALQAYGGVGAEPPPRGAPGGRPPGQAQAAGLRRSRPKGGEQDAPPPSAYRYWPVFATVSMERPASVPALPETSVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1K4</accession>
    <name>A0A1H6C1K4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ORF">SAMN04489712_108227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66822">
        <property type="protein sequence ID" value="SEG66822"/>
        <property type="gene ID" value="SAMN04489712_108227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG66822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="10241" checksum="E319B391EEC093C5" modified="2017-01-18" version="1">MAGLGWTEILIILAVVMLLFGSAKLPQLARSLGKSARILKAETKGLREDDDEAKPAQPAPPQQPPAQQYAPPPQGQLPSGEPIQGVPVDPNQARNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C390</accession>
    <name>A0A1H6C390_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyrroloquinoline quinone biosynthesis protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67429">
        <property type="protein sequence ID" value="SEG67429"/>
        <property type="gene ID" value="SAMN04489712_108286"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022479">
        <property type="entry name" value="PqqD_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03859">
        <property type="entry name" value="PQQ_PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG67429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="110" mass="11789" checksum="1B4C010F52D5A7F8" modified="2017-01-18" version="1">MTGIGPRSRLRPRSGVRLVFDEVRGSHALLYPEGVLLINETAARVLGACTGESTVADLVAALDAEYDGVCAEEVLALLSRLVTARLLHVAEDGSPRAADQDRFEGDEDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C909</accession>
    <name>A0A1H6C909_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69392">
        <property type="protein sequence ID" value="SEG69392"/>
        <property type="gene ID" value="SAMN04489712_10979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="36"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="316" mass="33926" checksum="EB64C862673B2D43" modified="2017-01-18" version="1">MTTSASGGAAGPANAALHQLTEDVYAWVQPEATWWVNNAGAVAGPEGVLVIDTCATEARTRRFLDALRAATGDVPLRYAVSTHLHGDHTHGNSLLPATTVLIAHEETRRGILADFIIDGCPPLWEPVPDWGAVTRRPPDLTMTSELAVNLGDRRVELRHPGYPAHTPGDVVAWLPQERVLFTGDLIFNGLTPMLGMGSVTGALRSLDWVASFEPARVVPGHGPICDEAALPEVLAAHERYYRFVLEVATDGLHDGVPPLEAVQRADLGEFATWADAERLAFNVHRVYADKTGEPFDLAKAALDAVTFNGGPMPTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMN7</accession>
    <name>A0A1H6CMN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_110170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73923">
        <property type="protein sequence ID" value="SEG73923"/>
        <property type="gene ID" value="SAMN04489712_110170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2040"/>
            <end position="2114"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3503"/>
            <end position="3578"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4044"/>
            <end position="4117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1563"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2022"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2119"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3482"/>
            <end position="3505"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1056"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2075"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3538"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="4079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG73923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="4117" mass="442230" checksum="71C09C4BAB6D332F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMQ3</accession>
    <name>A0A1H6CMQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74319">
        <property type="protein sequence ID" value="SEG74319"/>
        <property type="gene ID" value="SAMN04489712_110213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011473">
        <property type="entry name" value="DUF1579"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07617">
        <property type="entry name" value="DUF1579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG74319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="160" mass="17968" checksum="A8D4CFF8D4751792" modified="2017-01-18" version="1">MTNDTTATANRPPVPHPRNRLLDVLVGRWRSQGRTVTTPAVRIEGFDDYEWMAGGFFLVHRVDVRMDDQRVEVIEMIGPYDPAGGTFPMRSFDNHGAFVTMQATVGDDGVWTFTGETERATLVIAEDGASMAARWERTDDGSTWHHWMDMTFTKTTASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNM9</accession>
    <name>A0A1H6CNM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_110246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74592">
        <property type="protein sequence ID" value="SEG74592"/>
        <property type="gene ID" value="SAMN04489712_110246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG74592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="33696" checksum="F63C2F17D6EA26ED" modified="2017-01-18" version="1">MTQTASRTRLPGAGVLSRQRSLDLLRNGNLLVVFLLLCVVAALLAPEFLTTRNIANLLQQSSLTGIVAIGMTLVILTAGIDLSVGSTAAFAGMLVAVLISDGVHPILAIVASLAAGAAAGAVMGGLSAYLALPAFMTTLAGLTSIRGLTYLLTDGTPAGGDLPEGFQLLGGGFIGHVPIVGLIFIGVTVIAALVLRGTTFGEYVYAVGSNREAARLSGLPVRAVTTAVFAISGLLAALAGVLLTSRLTIGQPTAFSGLELDAIAAVVLGGTNLFGGRGKVFGTFVAVLLLSVLKNLFNLVGLSSFFQMVVTGLILVAALILNRVLENRGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CP54</accession>
    <name>A0A1H6CP54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyribonucleoside regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74577">
        <property type="protein sequence ID" value="SEG74577"/>
        <property type="gene ID" value="SAMN04489712_110244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="66"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG74577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="34402" checksum="F5DD282763EB2B65" modified="2017-01-18" version="1">MTADDPEYEALLLRVAEMYYEGDQTQEQIGRKLHLTRWKVGRLLSEARAVGIVRIEIVHPRHRLHTQEKALTERYGLRDAVVVPADGAADDLELRDRVAGAAAHYLADLSPAPRTLGVSWGRTLDAVAAHIQPGWARGVHVVQVNGGLSRSRRPTSASDMASRLAHHGGGTVTLLSVPAIVEQDATRRVLENDRSVAGVLDLARHCGAYLFSPGALSRDSVLVESGYLTAKDVTTLADAQGVGDVVGRFIDAEGHIVWDELDRRTLGVTLDDLRNGNWSIAVVAGAAKHRVSRAVVASRICNVLITDQHTAAHLLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CU74</accession>
    <name>A0A1H6CU74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_111171</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76502">
        <property type="protein sequence ID" value="SEG76502"/>
        <property type="gene ID" value="SAMN04489712_111171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006996">
        <property type="term" value="P:organelle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022170">
        <property type="entry name" value="MUL1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12483">
        <property type="entry name" value="GIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="GIDE" evidence="13">
        <location>
            <begin position="81"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG76502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="25045" checksum="C3CAFB85498D3DF3" modified="2017-01-18" version="1">MYILVAIFAAVFLAVGWVGRMQYTAMLRTVTLTCAQLTVQAPFSAKCEVTGTVRGPAGPMLTAPFSGTPCVWYRVRATAKHRTGSDNEFHKEDSEAPFEVWDGTGAIEVFPEGKNIDGTVKSFDAKVSPGNGGALPTPAWSPDQDKEYHYEEWTLPVGSALYARGTAMFDGRRLVMRAPGGHGDESDPYILSTRSEKQLRRRALALMLVGYVVGALLVVLAGVVAVIESNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUC5</accession>
    <name>A0A1H6CUC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76135">
        <property type="protein sequence ID" value="SEG76135"/>
        <property type="gene ID" value="SAMN04489712_111127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="223" mass="25678" checksum="3BE9A95F25546AF2" modified="2017-01-18" version="1">MAGEHPETMQERFSARLRAATRADHGHNEDSTYMSALLEGRLGREEYAALIGQLHFVYDLLEEAADRMRDDEVGGLFDLDGLRRREALQADLAFFHGPDWAERTTANEATRRYCERMREVCFDWPGGFVAHHYTRYLGDLSGGQVIGDRVSRTYGLTGDEGVRFYRFAERPKRLKDRYRELLDTAPWDEAERLRIIEEVRTAYRLNAELAACLARELSIEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVK7</accession>
    <name>A0A1H6CVK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DksA/traR C4-type zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_111251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77119">
        <property type="protein sequence ID" value="SEG77119"/>
        <property type="gene ID" value="SAMN04489712_111251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG77119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="114" mass="12722" checksum="E1731DFF5D20080E" modified="2017-01-18" version="1">MTANTVHGTSGEYSPGSTAARQARERLERERRNRAAQLIVLEGPDEGQPDETAPGRLDTLRRTLEEIEEALGRLEEGRYGLCEGCGKPIPEGRLEILPYARFCVVCQQRQRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CWG5</accession>
    <name>A0A1H6CWG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76726">
        <property type="protein sequence ID" value="SEG76726"/>
        <property type="gene ID" value="SAMN04489712_111198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="444" mass="45836" checksum="92A071A0735F9CD5" modified="2017-01-18" version="1">MEPAPAAPAHTAPARRASPAGRTPRIPAHTDPAHRVLALPDRTDLATWILEVPIRTDPAERILETPDRTDPAGRTPRIPDRMDPAERIPQVLARTDPAHRAPELPERTDLAGRIPPVPDRTDPAHRASPVGRVPGAPDRTAPAEDPEAPGLRALGLADTARGRREPPGHRTRVHREKGRPDRAAPAAEADPPSPARPAAAAPGAARPATAGLGAPRPATADPAAAGSGSRASPVRRPAANRAQAVETPPVAPPHRRAGRAGALPGASAAPLRTRAADPAEAAAARCPAAGAQDRHRTGGTPPQAGAAHSPSAPAPVPAPGTAAGSRARGRRGSPGSGPPAGRRAVARSPAPGIRSRRVPCSWRPERPVAPRGNDGPDRFSPPVLPPDLSPSGLSRTGLQQPKATCTPSNTATSPENTVPRRCCRPVTSPRPRLPLRRPPQAPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CXZ0</accession>
    <name>A0A1H6CXZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L,D-transpeptidase catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG77922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77922">
        <property type="protein sequence ID" value="SEG77922"/>
        <property type="gene ID" value="SAMN04489712_1121"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295347" evidence="3">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG77922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="111" mass="11638" checksum="C6F102CF7998D6AF" modified="2017-01-18" version="1" fragment="single">RRLTLVRSGRKIGAWTVAVGAAKTPTPAGRTFLLGLLKPSDPKPSPLIMPVGAHSETLDTFGGGPGTVAFHGWADESVFGRAVTHGCVRVPDDALTRLSKVPLGTQVLITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1M2</accession>
    <name>A0A1H6D1M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_112111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78685">
        <property type="protein sequence ID" value="SEG78685"/>
        <property type="gene ID" value="SAMN04489712_112111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="5">
        <location>
            <begin position="23"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="6">
        <location>
            <begin position="112"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG78685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="333" mass="35181" checksum="652DEF21565202D0" modified="2017-01-18" version="1">MAMTEPPLVVITDSDLPGDEPERILRSAGLRVRRASCRRAEEVAEAARDATALLVQWAPITAPVLDRLDRLRFVSRLGIGYDMIDLAGATARGIAVANTPDYCVEEVAAHTIAMVMALARRLPGLDRAVRGGRWSATGDGAGALRPSRATVAVIGFGRIGSLVAAHAAALGFRVVVHDPHVDEAAVRAAGHKPSQLEEALAVADIVTLHVPLTDLTRHLLNGETIARMRPGARIVNTCRGELIDETALAGALASGHIAAAALDVFEQEPLPAASPLRDAPGVLLTPHAAWYSPDSLQELPRRAARQIVDFLQGRPVPSIVNPEYATARTGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2Z2</accession>
    <name>A0A1H6D2Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_112202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79348">
        <property type="protein sequence ID" value="SEG79348"/>
        <property type="gene ID" value="SAMN04489712_112202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="460"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="819"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="1106"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="483"/>
            <end position="490"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="837"/>
            <end position="844"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG79348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1324" mass="144435" checksum="34B2B49F6CEC7442" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D591</accession>
    <name>A0A1H6D591_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mtnA</name>
        <name evidence="3" type="ORF">SAMN04489712_113100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80537">
        <property type="protein sequence ID" value="SEG80537"/>
        <property type="gene ID" value="SAMN04489712_113100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="347" mass="36235" checksum="5CE30CBA289CA185" modified="2017-01-18" version="1">MDEEPNVAELQAVTWTGDALRLIDQTVLPARLEHLEVRDVDVLVDAIRRLVVRGAPALGVTGAYGVAVAMLQAEREGWDRAALEAAVDRIRTARPTAVNLAGGVDRVRPLIGDGLAAVTAEAGRVLREDVAANRAMGAHGADWIARRVSRRPLRVLTHCNTGSLATAGWGTALGVIRELHARGLLEMVYADETRPLLQGSRLTAWELAHDGIPHRVLADGAAASTILRGLVDVAVIGADRIAANGDTANKIGSVGVALACADAGIPFVVAAPWSTIDPGTATGEDIPIELRDGREVLAWEGARTAPAGSEGFNPAFDVTPARLISALVTETGVLEPARGRVPVPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8Y4</accession>
    <name>A0A1H6D8Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette, subfamily B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_114116</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81679">
        <property type="protein sequence ID" value="SEG81679"/>
        <property type="gene ID" value="SAMN04489712_114116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="330"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="362"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG81679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="571" mass="60674" checksum="2202E2899EF2F3E3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D932</accession>
    <name>A0A1H6D932_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81810">
        <property type="protein sequence ID" value="SEG81810"/>
        <property type="gene ID" value="SAMN04489712_114149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="18641" checksum="031724D276F04F10" modified="2017-01-18" version="1">MILPKVRDPRFVTIRRGGTLTDADHHLLALWAASCAEHVLDLFESVQPEDPRPRQAIEYARAWVRGEVKMMEARAAGGHAMGAARDLRGAARHAAYAAGQAGVVAHVAAHELGAAAYAIKAARAAAPEGEGEAAGRLECQWQRDQLPEAIRELVLDDQRLRNDICWSVFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DA97</accession>
    <name>A0A1H6DA97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81615">
        <property type="protein sequence ID" value="SEG81615"/>
        <property type="gene ID" value="SAMN04489712_11497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="157"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG81615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="417" mass="44960" checksum="A2CD50843A04A7B0" modified="2017-01-18" version="1">MKLAVEAPGPLNVRTEPIADPGDLPARLPHPTALAWVHHGEGIVGWGETARITIPGGQDRFTHADQCLRHLFADATIDDPVDQPGTGPVAFGSFTFDPESSDSVLIIPRHILGRRNGQAWLTTIGTHPHTGDPLTLAHPPTPPTHLRWSDGTLTAPAWQQAVATAVDRIRHGHLGKTVLARDLTVQAAEPIDTRVLLARLATRYPACFTFAVDGLIGATPELLIRRTGDHIDSLVLAGTTPRGATPTDDHTRAQHLYHSTKDRQEHAYAADMVRDALTPLCTDLHVPHQPEILTLPNVIHLASPVHGTLDRQRSVLDVLAALHPTPAVCGTPTTPALNLIRELEVMDRGRYAGPVGWIDAHGDGEWGIALRCAELDKTDPTRARLFAGCGIVADSDPATELAEAQAKFRPMQEALQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBX2</accession>
    <name>A0A1H6DBX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">SAMN04489712_11571</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82719">
        <property type="protein sequence ID" value="SEG82719"/>
        <property type="gene ID" value="SAMN04489712_11571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG82719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="11571" checksum="487E343EC090FBE9" modified="2017-01-18" version="1">MWITDWTARAACRNADPDALFVQGAAQNRAKLICRGCPVRTECLADALDNKIEFGVWGGMTERERRALLRRRPDVSSWRDLLETAKEEYERSADDQGELVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DD89</accession>
    <name>A0A1H6DD89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82685">
        <property type="protein sequence ID" value="SEG82685"/>
        <property type="gene ID" value="SAMN04489712_11563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041467">
        <property type="entry name" value="Sco4008_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17926">
        <property type="entry name" value="TetR_C_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG82685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="23108" checksum="7B15BC5CE9472165" modified="2017-01-18" version="1">MSPSKPRRSPKPQERQRDPDRTRKRILDAAAAEFAAHGYAGARISAIAARAGVNQQLISYYFDGKEGLYQAISQHWRQRESELAPPGMPLPEQIHQYALEALNNPDGVRLMAWSGLEYTGPETDPDHAPRAERLQRSIDEISALQAAGRLPAEVDPACLTVMLMAAAMATTTLPHVIEGVCQVDPRSPEFVHHYADQLTILTRILGLGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDU9</accession>
    <name>A0A1H6DDU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83538">
        <property type="protein sequence ID" value="SEG83538"/>
        <property type="gene ID" value="SAMN04489712_11616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022060">
        <property type="entry name" value="DUF3616"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12275">
        <property type="entry name" value="DUF3616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="39120" checksum="451A62256513CF9A" modified="2017-01-18" version="1">MIVERRVELRFAEESQAAETHTNLSAVRQDGRCLWVAGDETATIERLTAEVDEAGRVTGYGDQRTVALADLVELPAGRDEEADIEGLARANGWLWAVGSHSLKRKRVKPEHGDAKARRRLATVVREENRHILVRIPLVPGPDGLPEAVATDGDRTAAVLGGRGDSLTDLLADDPHLAPFLPIPSKDNGVDIEGIASVPSPDGERLYIGFRGPVLRGWAVLVEIHPETDPADPHRLRLRRLDGRARYRVHFLDLGGLGVRDLCPDGDDLLILAGPTMSLSGPVRVLRWRGAAKTTAADIVHARELERVGDLPHGEGEDHAEGIAVLDETHGPGPTLLVVYDSPAGGRLTEHGGVHADVVSFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGW6</accession>
    <name>A0A1H6DGW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_116119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83993">
        <property type="protein sequence ID" value="SEG83993"/>
        <property type="gene ID" value="SAMN04489712_116119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="61"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="445" mass="46573" checksum="1C83D30A445A396A" modified="2017-01-18" version="1">MPFPDRSDSPPAEPPAGRTGISATLAANETLERKRREGVPVLPMAFGEAGLPLHPALRRELAEAAGRNAYGPVAGSPELRAAAAGYWTRRGLPTEPGLVVAGPGSKALLFGLLLVIGGEVAVPRPSWVSYAAQAALTGAGALFVPTPPDEGGVPDPGLLANAVQRARRQGRDVRSVVVTLPDNPTGRLAGEPTVRRLCEVARELDLLIISDEIYRDLVHDPAHAVTSPAAYAPERTVVTTALSKHLAAGGWRLGVARLPDGPRGRTLRADLLGAASEIWSCAPAPVQRAAAYAFGEPPELAEHVTRSRGLHAAVAHAVADRFAAAGCRVPRPHASFYLYPDFGPLAGRLAARGVRTGPDLAALLLDRYGVGTLPGSAFGEPDGALRLRVATSLLYGEDDEQRLEALASPAPQTLPWIARSLDRLSQVLAEVTAPEPALAGSPAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHW8</accession>
    <name>A0A1H6DHW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">60 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_1171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84423">
        <property type="protein sequence ID" value="SEG84423"/>
        <property type="gene ID" value="SAMN04489712_1171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG84423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="510" mass="54046" checksum="C72A10056250D307" modified="2017-01-18" version="1" fragment="single">MAARMIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPWEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPMSLKRGIEAAVERVSEELSKLAKDVETKEQIASTASISAGDVRIGEMIAEAMDKVGKEGVITVEESNTFGLELELTEGMRFDKGYLSPYFVTDAERLEAVLEDPYILIVQGKVSSNKDMLPVLEAVMQAGKPLLIIAEDVEGEALATLVVNKIRGIFRSVAVKAPGFGDRRKAMLGDIATLTGGQVISEEVGLKLENTTLDMLGQARKIVVTKDETTIVDGAGDAGEIAGRVNQIRTEIDATDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVPGGGVALLQAGAKAFDKLELSGDEATGAGIVRRALEEPIKQIAVNAGLEGGVVVEKVRNLPAGEGLNAATGEYVNMFETGILDPAKVTRSALQNASSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIT1</accession>
    <name>A0A1H6DIT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84486">
        <property type="protein sequence ID" value="SEG84486"/>
        <property type="gene ID" value="SAMN04489712_11712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG84486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="28633" checksum="81DEBEDC7373FA93" modified="2017-01-18" version="1">MTDTETIDETPAARAARFRAEAAARGIPAAEVEAYIRTARPAVYLAPDGPGPVMALTGGNPPLPEGAPAPAAAFVAAVDCAALPPGATDLPLPTEGRLLFFADPDPGSGAVVADAVRYMPAGTPLAERPVDPDDGPGTYRRARLDFCFYQWSWPWREEDDDEESQRAAELESAWSQVVGWRPHWRFQLGGEPVLFNWDPVEVVRDEVPLPVADGDEWTLLATWRGEDDCEELEAGLFHWVIRRADLAALRFDRVYVYVDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKQ2</accession>
    <name>A0A1H6DKQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">23S rRNA (Guanosine2251-2'-O)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85719">
        <property type="protein sequence ID" value="SEG85719"/>
        <property type="gene ID" value="SAMN04489712_11866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="32004" checksum="6A1F04A2BB5A6AEC" modified="2017-01-18" version="1">MAKRRKKGPSFTPKAEDRHWHGKRQQARAAKSAARTGTRTTGPRGAARPAEPARSGRPAGARRAGGAEAPELVMGRNPVVEALRAGVPGSALYVMSDTDERVREAIKLAGDRNIPLLQAGKGELDRLTDGAVHQGIALQVRPYRYAHPDDLLRRGTPPLIVAADGVTDPRNLGAIVRSAAAFGADGVVVPERRAAGVTAGTWKASAGMLANLPVAQTTNLARQLKAYQQAGCFVAGLDARGGVTVADLELADGPFVLVVGSEGKGLGRLVAETCDLLATIPMPGQAESLNAGVAAGIALYEIARRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL51</accession>
    <name>A0A1H6DL51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85436">
        <property type="protein sequence ID" value="SEG85436"/>
        <property type="gene ID" value="SAMN04489712_1183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG85436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="7338" checksum="A003D5DEE580CEDE" modified="2017-01-18" version="1">MAQGTVKWFNAEKGYGFIEVDGGRDVFVHYSAILADGYRSLEQGQRVEFEIAQSDRGPQAESVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP41</accession>
    <name>A0A1H6DP41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86305">
        <property type="protein sequence ID" value="SEG86305"/>
        <property type="gene ID" value="SAMN04489712_11948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="42"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="326" mass="35629" checksum="BDF1ED8986EB55A8" modified="2017-01-18" version="1">MSIPVSEQHTAAYRARKVPAPLRVTDGVWAVPVPLRGSPLRFITVFLVETSEGLVLIDAGYEHPSCWESFTGSLAEIGHDLGAVRLVLLTHNHPDHVGFADRVRATTGAKVVMGRDDDFAHQKRVRGGGFLVQLRRALELTGAPQEVIDGMYDAAVPVARHSESLELDLAPERDTEHVLGDVTILGIPTPGHTYGHTVYVDTSRGVVFTGDTMMAEGPTQLAIPSLPADNPAGDLLTSLDRIRDLGVEIACPAHQFPYRDIAARARELKAFHQAELDTVEKLLRTHDSAWEIAPHLNRARPWEELGTGARRFALIHTLSLVLAVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQA4</accession>
    <name>A0A1H6DQA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86856">
        <property type="protein sequence ID" value="SEG86856"/>
        <property type="gene ID" value="SAMN04489712_12019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="17915" checksum="4A521F4CCA6811C4" modified="2017-01-18" version="1">MDEQRTPARSGDLPPAEIAALALSLAHLGSGPQAAAARRALRHLTADLDPADPIVVDTLTTLTTPLTEAVADRARVIAEAITERRVVRLCYGDANANVTIREVEPVTCLVHRDHWHFIGWCRMRRGVRAFRFDRILAVEPTGTPAALRPVSGFLPWRRTAAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRR4</accession>
    <name>A0A1H6DRR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87969">
        <property type="protein sequence ID" value="SEG87969"/>
        <property type="gene ID" value="SAMN04489712_12147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="15448" checksum="BBF81C51B6AC8390" modified="2017-01-18" version="1">MVGEPSVRAVGWARSLPMTSRVKDARDWAREHLDSLGWTTTAPQTVDAVLLTVSELVTNAHVHAHSNAQLVLTWDSRCLHVSVHDSSTDLPVPRPASTEHVGGRGMFLVDALADTWQAHPCPDGKTVTACFRPSADSAGSDDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSJ8</accession>
    <name>A0A1H6DSJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_121100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88218">
        <property type="protein sequence ID" value="SEG88218"/>
        <property type="gene ID" value="SAMN04489712_121100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="13139" checksum="BCF52F2E57E73FCD" modified="2017-01-18" version="1" fragment="single">MEQILYEVKDRVAVISLNRPEVANAQTMDLLDDLDAAWSRAADDEEVRVIVLRGNGKHFSAGHDLKSGAPAPEKLTLEWIYTIEARRYLEYCLRWRNVPKPSIASVQGKCIAGGLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVW5</accession>
    <name>A0A1H6DVW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89398">
        <property type="protein sequence ID" value="SEG89398"/>
        <property type="gene ID" value="SAMN04489712_12384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG89398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="379" mass="37929" checksum="9E279D053341DD34" modified="2017-01-18" version="1">MSVAVVPNCLRGTASADTVAHALGRGAGTAPGVGEVVLLPAADGGDGTTDVLARSPGAVRHVLPVSDALGRRKNASWLLMTETTAVVESAASCGLASLRPAELDPLRATSAGVGEMIAAAVEAGARHILLGAGGTAYVDAGAGALGALGARFFDATGATLPPVPWALRDVASVDLRPAIRRLGDVTIQVLADVRIGLDESIGRFGRQKGVTEANRGVLAETLARIVRVLAADEHRLWSSGAERLWTRPWLGAGGGVGAGLATVATTSGESGALRVLDLLGAMPAVLESDVAITAEGRVDATTWLGKLPGTVASLRTARGLPTVIVAADADLSGGAPEGGLVKILPFGADAQGEPPPSLADMLASTGARACTGRTATGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYH9</accession>
    <name>A0A1H6DYH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90378">
        <property type="protein sequence ID" value="SEG90378"/>
        <property type="gene ID" value="SAMN04489712_12619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG90378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="437" mass="48355" checksum="1C688CCCEAD4D1F2" modified="2017-01-18" version="1">MGKRHGRHIHLGLWLTFLDAADWRNPDSRAEELNSLAPYVEVAEIGERAKLDALIRGDGLGLPLPSPDQAYAGSLEILTLLAALAARTEKIGLIGTASTTFTEPYNLARTLATLDHISNGRVGWNIVTSVAGEEQFGYDQIPGHEERYERADEFIEVVSKLWASWESDAVLVDRENGVFFDPKKINRIDHHGKHFHVAGPLNIARPPQGRPVFVQAGDSDRGRNFAAEHAELVFTAQRDLEKAQAFYRDVKERVKRQGRDESRVSILPGLVVTIGATEAEARELHDQFLARIDYERTRTSLEALLGGIDLSDIDLDEQVPEERLPEAATLTRQPGRAQIFVDLAKEKGATLRQLLQALGTAHGHGRVFGTPRQVADHIERWAEAGAADGFAISPAQGLAGARLFADEVVPILQDRGVFRREYTGSTLRDHFGLWPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZA9</accession>
    <name>A0A1H6DZA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG89975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89975">
        <property type="protein sequence ID" value="SEG89975"/>
        <property type="gene ID" value="SAMN04489712_1253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="85" mass="9385" checksum="D53620416BD9CFF4" modified="2017-01-18" version="1">MSPRRPSVCLEDVADDELPKLVPHLPSGFGDRFVPPRTSSGRPIRRAWPCSSVSEVVAQVALGRIVHATVTRMQMFENREDISAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0H5</accession>
    <name>A0A1H6E0H5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90879">
        <property type="protein sequence ID" value="SEG90879"/>
        <property type="gene ID" value="SAMN04489712_12765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="34097" checksum="BA788D7855B59051" modified="2017-01-18" version="1">MTAHEPRPGGDVTFSVVVLTMGNRPTELARAVRSALDQENVDVEVILVGNGVPGDWTPGDDEVFEDKRVTLVRLPRNVGIPAGRNRGVAASTGEIVLFLDDDGWYRSTRLGAHLRDRFAADPSLGIVSFRVRDPEGGPGERRHVPRLRAGDPERSSEVTTFLGGACAVRRAAFDAAGGLPEDFFYAHEETDLAWQAMNAGYRIVYDASAVMYHPAVLPTRHEMFYRYNARNRVWLARRNLPWPLALAYCAVWVAMTLLRERKPAALRPWFKGFAEGWRKPAGPRRPISWRTAWRMTRIGRPPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1H5</accession>
    <name>A0A1H6E1H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenine-specific DNA methylase, contains a Zn-ribbon domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91033">
        <property type="protein sequence ID" value="SEG91033"/>
        <property type="gene ID" value="SAMN04489712_12819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="723" mass="79741" checksum="88047864A9A9870C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E269</accession>
    <name>A0A1H6E269_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain-containing protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91096">
        <property type="protein sequence ID" value="SEG91096"/>
        <property type="gene ID" value="SAMN04489712_12834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="61" mass="6952" checksum="3690121A0A1694F4" modified="2017-01-18" version="1">MNENERVLTLDEAAALLRLSRWSLYNLIRSNRLRTIKVGRRRIVPAAAIDEFLGESLEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2U6</accession>
    <name>A0A1H6E2U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91671">
        <property type="protein sequence ID" value="SEG91671"/>
        <property type="gene ID" value="SAMN04489712_13018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296536" evidence="4">
        <location>
            <begin position="28"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="5">
        <location>
            <begin position="589"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG91671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="744" mass="80135" checksum="743885D5CA166A5D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4A9</accession>
    <name>A0A1H6E4A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92141">
        <property type="protein sequence ID" value="SEG92141"/>
        <property type="gene ID" value="SAMN04489712_13237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="117"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="34496" checksum="9B6E41FD142A5E7A" modified="2017-01-18" version="1">MDDRRPWRVLALPPLGENIIRGMFAPLSEAVEVSVPATRDVPGLHAALADAELVVGDFTGALALDGAAVRAAPRLAFVQMPQVGVDSCDLDALTGAGVPVANTAGANARSVAEWAVGAAFALCRQLAWGDRRMRAGEWSQSALLGRGTREIHSRRVGVLGHGAIGAEAAGLFAALGCAVSYWSRSRRPDASATYRELDDLLATSDILVLALPLTPETAGLIGPERLATLPPGALLINVARGGIVPDEAVLAALDSGRLGGAALDVFEDEPLGVDHPLRRHENVLLSPHVAGATLEAQLNIVSLVRDNVAAAVAGRPVRNVVNGVEPLVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4G5</accession>
    <name>A0A1H6E4G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92191">
        <property type="protein sequence ID" value="SEG92191"/>
        <property type="gene ID" value="SAMN04489712_13252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="84" mass="9262" checksum="9DA4A373E7F2ACC9" modified="2017-01-18" version="1">MQSQSPPLMRDCPLACLTPSPRIVNPLRDYLAGEGVREPTVGDVVRLWEHDRLRFVKNLGPGGTEQLLGVLVAAGLIHQHHHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4X4</accession>
    <name>A0A1H6E4X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92064">
        <property type="protein sequence ID" value="SEG92064"/>
        <property type="gene ID" value="SAMN04489712_1329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="12762" checksum="70DDFA2BEFEFDF80" modified="2017-01-18" version="1">MTPPRNRKALVRPHVVTAGRARPSRNIFDLVTLVIATSGGVGPLTPEKRRIVTLCQGGALSVAEVAGHLDLPPSVAKVLLSDLVDSGHITTRANAPADPADRSAHERLLREVLDGLRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E681</accession>
    <name>A0A1H6E681_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92464">
        <property type="protein sequence ID" value="SEG92464"/>
        <property type="gene ID" value="SAMN04489712_1343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="18948" checksum="DA3238F1B438F416" modified="2017-01-18" version="1">MPPDPGAALAVIKSYWRERATAGLPDARRAPVLAVDQLRTLVAACALPPEPLAPVDVGLGDLLGAAAPPPVPVPRPQALVVCDQFLLVLGWAMMARRGELAALNLPDVVEVAQGLEVAVRQSKVDQHAVGRIAAIPYGGGASHETVRRTILGLSVPSRWETAEAVLLALCELAGVNPDESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E892</accession>
    <name>A0A1H6E892_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93942">
        <property type="protein sequence ID" value="SEG93942"/>
        <property type="gene ID" value="SAMN04489712_1422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="1">
        <location>
            <begin position="238"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="42981" checksum="D56DCF8D538F0E59" modified="2017-01-18" version="1">MTSPVLDTIMERAEEIRALGSVNEQLGRLDDKAAKVLRDSGMIRMLQPASYGGMEAHPREFAEAVMQIAALDGSTGWIAGIVGIHPWEMAMADPRVQQEIWGEDPDVWIASPYAPMGIARPVDGGYVFNGRWQFSSGTDHCDWIFLGAMLGDADGNMVTPPVGLHLILPRSDYEIVEGSWEVAGLKGTGSKDIIVRDAFVPDYRAIEFAKVIDGSQAREAGLTNPTYLVPFSCAFPLGITSAVIGMAEGALAHHLAYQRDRVSIVGTKIKDDPYVLYAISEAAEEIAASRTRLLDFVCRMHDEAAAGREVSFGERAAGRRTQVRAAWRAVQAMNEIVVRSGGNAMRTDNPIQRFWRDAHVGLSHAIHVPGAVYHVSALTDLDIEPPQGPMRSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8S6</accession>
    <name>A0A1H6E8S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93334">
        <property type="protein sequence ID" value="SEG93334"/>
        <property type="gene ID" value="SAMN04489712_13823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="11982" checksum="80D27E95FA8548AB" modified="2017-01-18" version="1">MRFPIDSTRLTFVVADAPQQARDFKTKQPKTTPEGAPVFVVSLLAMDGKDSAPVRVRLAGDPGLAQGQPVQVAGLVLNKSSGASDMSWWTADAVLPLAPAPSQGGPRSASTGKAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBJ0</accession>
    <name>A0A1H6EBJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000067">
        <property type="protein sequence ID" value="SEG95122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95122">
        <property type="protein sequence ID" value="SEG95122"/>
        <property type="gene ID" value="SAMN04489712_1672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG95122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="30" mass="3206" checksum="A894677CBBB0688C" modified="2017-01-18" version="1" fragment="single">QTIRILIDTADTSTASLIESAIDNITITQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBL8</accession>
    <name>A0A1H6EBL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_14717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000047">
        <property type="protein sequence ID" value="SEG94429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94429">
        <property type="protein sequence ID" value="SEG94429"/>
        <property type="gene ID" value="SAMN04489712_14717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="45"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG94429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="15551" checksum="6A979A6BCC1D7C7C" modified="2017-01-18" version="1">MGFVGTLVPGKSAEDADNEYMLLQTYLAASAEPDFDVTVHSGEAGLVIARIRGELDLATADRLHRLVHAAMSSGRRARVLLDLGGVTFCDAQGLSALVRIANDAQGGGGELSLTRIPPVIARLLRLTGLDHRFPVTVVAMAVPQSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBN7</accession>
    <name>A0A1H6EBN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abhydrolase_10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94324">
        <property type="protein sequence ID" value="SEG94324"/>
        <property type="gene ID" value="SAMN04489712_14613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045394">
        <property type="entry name" value="Abhydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20091">
        <property type="entry name" value="Abhydrolase_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296787" description="Abhydrolase_10 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_10" evidence="2">
        <location>
            <begin position="59"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="459" mass="49489" checksum="E829474A834E25D1" modified="2017-01-18" version="1">MTMPSRTSRILLTAMIAGALTAGGPAAAARQAPEPVPVPTVEGPVPGTVPGDPSSPDVRDTYPWMSTDVDLASAGYVEQEFYVSGAADGYSTAGDLVGSDVPYRTRIIVRRPAHPARFNGTVLAEWQNVTAGYDLDALWSHEQIMRAGYAWVGISAQRVGVDHLRRWSPARYGNLDVTGAGRFTADELSYDVFAQVAKALRRPGRVAPLGGLKARTVLAVGASQSAGRMTVYYDAVLPRTESVFDGFANIVGNAPSREGAEPVFQVLSETDVRTPVRRPDGDRFRRWEVAGTAHSGWHGQRYRQSILERDLGAAPSYDCARPPFSRVPLHHVIAAAYDHLTRWARQGVRPPSAPPLEFGPDGTKARDDLGLARGGIRLSQVEAPTALNTGDNSGESFCFLFGTHIPFDRPQLDALYPSHGRYVSAVVKADRHNVRAGYLLPGDAHSNLREAAASDVGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5RYL3</accession>
    <name>A0A1H5RYL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43446">
        <property type="protein sequence ID" value="SEF43446"/>
        <property type="gene ID" value="SAMN04489712_1018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="490"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF43446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="573" mass="60633" checksum="19BEB23D78ACF07F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S2E9</accession>
    <name>A0A1H5S2E9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein SAMN04489712_10153</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44765">
        <property type="protein sequence ID" value="SEF44765"/>
        <property type="gene ID" value="SAMN04489712_10153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF44765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="110" mass="11820" checksum="1A90E2158DF770EE" modified="2017-01-18" version="1">MILSTMNDLPGHQVTEVLGDVFGLTVVVRAPASQIEAGLRTFFGGGEARGLAGQLHEGRLEARRRLREAAGELGADAVLAMRFETSELREGGLEICAYGTAVRARRIEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SG84</accession>
    <name>A0A1H5SG84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">SAMN04489712_101175</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48948">
        <property type="protein sequence ID" value="SEF48948"/>
        <property type="gene ID" value="SAMN04489712_101175"/>
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        <property type="reaction ID" value="UER00183"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
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        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
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        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
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        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
    </feature>
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            <end position="174"/>
        </location>
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        <location>
            <position position="32"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="6"/>
        </location>
        <ligand>
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        <location>
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        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="32"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
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        </location>
        <ligand>
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        </ligand>
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            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEF48948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="23576" checksum="9122423CAA72BF60" modified="2017-01-18" version="1">MKISPSILSADFARLAEEVALISETADWVHVDVMDNHFVPNLTLGLPVVEALLKHSALPLDCHLMIEDPDRWAPQYAEAGAGSVTIHAEAAKAPIRTLRAIRAAGARAGLGINPATPVEPYEDLLGEIDMLLLMTVEPGFGGQKFLDVVLPKVRRARQLIKGRDLPVWLQVDGGVSAETIERCAEAGADVFVAGNAVYGADDPAEAVRNLRAQAEEATGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SH32</accession>
    <name>A0A1H5SH32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent oxidoreductase, nitroreductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
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            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
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        <property type="gene ID" value="SAMN04489712_101202"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF49760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="18322" checksum="B408A83973E184AE" modified="2017-01-18" version="1">MPKPRPRSHDASWTPRFMKLMSRAHVRAYRATGGLVGGRMRIGSAWLRGVPVCLFTTTGRKTGLPRTRPLLYMRDGDRVVVVASQAGLPTHPQWYRNVQADPQVTVQIRRRRWRMRARTADDAERAELWPRLLAVYADFDDYQRWAGDRVIPVVICEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJV9</accession>
    <name>A0A1H5SJV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uracil-xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50047">
        <property type="protein sequence ID" value="SEF50047"/>
        <property type="gene ID" value="SAMN04489712_101212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
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        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF50047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="516" mass="53474" checksum="31DA5F77BEB12D47" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SK96</accession>
    <name>A0A1H5SK96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50864">
        <property type="protein sequence ID" value="SEF50864"/>
        <property type="gene ID" value="SAMN04489712_101243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16925">
        <property type="entry name" value="TetR_C_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF50864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="20664" checksum="94831D2783427BFD" modified="2017-01-18" version="1">MTMATDSRERMVRSAAYLFRERGYSGTGFRDVIAHSGAPRGSIYHHFPGGKVQLAQEAVRYAGEFLNAGIEAAVEGGDPAAAVDAFVGWWRTVLVRSEFRAGCPVVAVTVESHDEAPQLADAAAAVFARWQDTLATGLGNSGVPDDRAARLARLIVAAVEGATILCRAHRDVRPLDDVVTELKELTRDAAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SMT2</accession>
    <name>A0A1H5SMT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51057">
        <property type="protein sequence ID" value="SEF51057"/>
        <property type="gene ID" value="SAMN04489712_101251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF51057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="134" mass="15062" checksum="7B90B4F4C3F0C4E6" modified="2017-01-18" version="1">MPLSEHEQRLLDQIERALYAEDPKFAHAVRAKDPQVHYKRRIVKAVLGFVLGVVVLMTGLVINAGTTTIVVSVTGFLLMVVACVWGLTSWKRMTGVGAEAESATRPRQGGARRPARASFMERMEERWRRRTEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SPI8</accession>
    <name>A0A1H5SPI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Right handed beta helix region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52350">
        <property type="protein sequence ID" value="SEF52350"/>
        <property type="gene ID" value="SAMN04489712_101302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="162"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF52350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="40578" checksum="E24E97A6BA01A0D7" modified="2017-01-18" version="1">MTDKIDLKFVAGLLIGALVMGALVVVLMSGGQDGERAADQSVPMPRGPVGAGASEDRGEDAEEDIEEAGEEGEPFTSAGPPPDIEVPDGEGRVVCPAATRTVGDARELQTALSTAEPGDSIHLEDGIYVGKFVARAAGTEDKPIFLCGGENAVLDGGGIKKGYALHLNQASHWRLVGFTVRNSQKGVMADTTDGAVIQDLRVHDIGDEAIHLRNFSSGNTVQYNLIYNTGLRREKFGEGVYLGTAESNWKQFSGGKMDRSDRNVVRGNVIRATAEAIDVKEGTTGGRIVGNIFDGSVLGGSKHNDSWVDVKGNGYVIEDNRGTETNEDGFQTHEIVKGWGTGNVFRGNTIDLGGGGGVGIKDTAGGNTIDCDNKVTGGPLTDKGQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SSL7</accession>
    <name>A0A1H5SSL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53623">
        <property type="protein sequence ID" value="SEF53623"/>
        <property type="gene ID" value="SAMN04489712_101349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF53623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="34049" checksum="1FD11513CC7C4594" modified="2017-01-18" version="1">MTDSYKTPTRGIPKVEVMKTLTTDRLTAAERFLWLNARVLERRRFQLLFQGGAAEPLTAALRPYENPDGGYGNALEPDLRGDGSQPVPAQHALELLHEAGQHDDPAIDRLCDHLTTITAPDGGVPFVLPSVRDTPHAPWWQTPDVPPGSLVPTATLAGQLHRIGSRHPWLPRATAFCWTAIDALNEVPPYIAYAVLTFLDHVPDRARAEAAFERLRKPILDSVTLDPHATGEAHFPLDFAATPHGFARRLFDDDLIDDHLDALIDAQTEDGGWTVNFPIWTPITGHEWRGVITVDRLKTLRAYGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SV56</accession>
    <name>A0A1H5SV56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54472">
        <property type="protein sequence ID" value="SEF54472"/>
        <property type="gene ID" value="SAMN04489712_101378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF54472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="31678" checksum="F888DA0573484F9B" modified="2017-01-18" version="1">MTAIVTGAAGFLGRALTRALLDGGEQVVGIDRLPLAPVPGLTVLTADLTAGDPMVRAALQSGDKVFHLAGRPGVRDRTAGIARLRHRDNVLAAAAVLDAVPPHVPLVVTSSSSVYGGTTDGRPSHESDPLRPRGGYARSKVRMEGLCARRLAEGGAVTIVRPFTVAGEGQRPDMAFSLWLEAARAGRPLRLLGSPDRTRDITDVRDAVRALIALAEVRARGVVNLGTGTGHSLRRMAEAVAAALGTPVSYVVEPAGADEVTDSLADVRRLVELTGFAPRTDLFDVVARQARSMGAVPDASGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TRX9</accession>
    <name>A0A1H5TRX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidase EvaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65544">
        <property type="protein sequence ID" value="SEF65544"/>
        <property type="gene ID" value="SAMN04489712_101724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005212">
        <property type="entry name" value="EvaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038153">
        <property type="entry name" value="EvaA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03559">
        <property type="entry name" value="Hexose_dehydrat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hexose_dehydrat" evidence="2">
        <location>
            <begin position="39"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Hexose_dehydrat" evidence="2">
        <location>
            <begin position="278"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="dTDP-4-dehydro-6-deoxy-alpha-D-glucose 1; pocket A" evidence="1">
        <location>
            <begin position="149"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="dTDP-4-dehydro-6-deoxy-alpha-D-glucose 2; pocket B" evidence="1">
        <location>
            <begin position="384"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="dTDP-4-dehydro-6-deoxy-alpha-D-glucose 2; pocket B" evidence="1">
        <location>
            <begin position="389"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="dTDP-4-dehydro-6-deoxy-alpha-D-glucose 1; pocket A" evidence="1">
        <location>
            <begin position="422"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" description="from pocket A" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>dTDP-4-dehydro-6-deoxy-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="from pocket B" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>dTDP-4-dehydro-6-deoxy-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="from pocket A" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>dTDP-4-dehydro-6-deoxy-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="from pocket B" evidence="1">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>dTDP-4-dehydro-6-deoxy-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="from pocket B" evidence="1">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>dTDP-4-dehydro-6-deoxy-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605212-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF65544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="488" mass="54079" checksum="E6A88FF6A298927A" modified="2017-01-18" version="1">MAELSAGSSVVPTGTRGDTALRIAESAMCRDGRVMDLETFHKWFADLGRRIYTRAERVPIDELEGWDSDPVTGNIGHRSGGFFTIEGLDVHIADVAVPDWSQPIINQPEVGILGILVKEFDGVLHCLMQAKVEPGNCDGPQLSPTVQATRSNYRRVHRGRATPYLEYFRDTARHRVIADVRQSEQGSAFHHKRNRNMVVEVTEDVEPLDGFCWLSIGQLHRLLADDDMINMDARTVLACLPVAHTGLADVLRPGADGFRAALVRSCDPDAPGVWSMGDVLSWITDTRSRTDVRIRRVPLKALPGWRRVDGRISHESGRFFDVIGVRVEASGREVSRWCQPMVEPHGMGVVAFLVKRVDGVLHVLVHARVEAGYVDIVELAPTVQCTPANYEVLPGPARPRFLDAVLAADRGQIRYEAVLSEEGGRFYHARNRYLVIEADPGPGAQSGDYRWLTVHQLADLLRHSHYVNVQARSLIACLYSLAAAPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TSP5</accession>
    <name>A0A1H5TSP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65790">
        <property type="protein sequence ID" value="SEF65790"/>
        <property type="gene ID" value="SAMN04489712_101731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF65790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="29322" checksum="B269C0F8C3428167" modified="2017-01-18" version="1">MTVQAGPSTAETLPDHIVRRYRDQGFVHVPNVLSEDEVAAFRAASDELLRKETPTIWGADEAEAQVHYIEEAWLKSDTLRGLALHPRLIGLARRLAGGPLRLYSSDVLVKKPREALPTLVHDDEAGLPLANLSRTLTAWVALVDVPVERGCLSYVPGSHLRPDSDRQIRMESFADYRPMEEVWPDFPWRPRVSVPLRAGDVAFHHFRTVHMAGPNTTDVPRMAHGVIYADEEATYQPGVQDQYLTHFQPGQRLGGEKFPPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U4P2</accession>
    <name>A0A1H5U4P2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69368">
        <property type="protein sequence ID" value="SEF69368"/>
        <property type="gene ID" value="SAMN04489712_101850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="176"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF69368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="323" mass="33923" checksum="74B55C8C293E4A76" modified="2017-01-18" version="1">MDHSTRQPLIEGITAAIVGVTDFGPHLELFVDRLGYEVAAAGTIPAAVADALWGSGPADLEVIALAAAGSGTGRIHLVRVPEPIAPAEPPHNLDTGLVGIDMYARDINAAHAALGKAGHPWTVAPTTYGVAVGEREVEVTQGICPAPDGTVVVFVQPAAVRGTEAWSADPERSYTELTSVVCHVPDPDAEVAFWGPEGLGMDVWYDVVFSSPGFDKVAGLPDGTRMRLAFLAGAKTARIEVTSADTEHRVDRRAAQRPARSLGHCGWSVRTRDLSAALESVRRTGGQVLTGRVETDDPWHGRAAAAGVTTPNGISVTLWQPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UT82</accession>
    <name>A0A1H5UT82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78190">
        <property type="protein sequence ID" value="SEF78190"/>
        <property type="gene ID" value="SAMN04489712_10210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF78190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="11614" checksum="89AAFC98CDBE46F9" modified="2017-01-18" version="1">MRPLNARIRTELEERQICLLRLHWELTRLGIRVRVRKSRNGRWKLKLRTTTGWSETVLCAGAEGAYAYVTAHGRLLGRTEDARQVARLLLWMLERRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V863</accession>
    <name>A0A1H5V863_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83336">
        <property type="protein sequence ID" value="SEF83336"/>
        <property type="gene ID" value="SAMN04489712_102204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF83336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="32241" checksum="DA43F94C0CE464AD" modified="2017-01-18" version="1">MLVLVTGAAGFIGSHLVDRLLADGHEVIGVDDLSSGRNLREDIEFHRMDVCDPALAELTARRRPELVCHLAAQVSVRSSVEDPRHDARVNVFGTVNVLEAARAAGSRKVLFASSCAVYGVPDELPVPPDAELRPASPYAASKVAGEIYAQTYRALHGLDFTTLTLANVYGPRQAPEGEAGVVSIFTDGLLNGTPTQVYGDGGNTRDYVYVLDVVEAFALAGGERAGGRRLNVGTGVQTTDRELHTLVAEAAGAVDKPDTAPPRLGDLRAMAVDPGPTREALGWRPRTGLREGLAATVKWARDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W406</accession>
    <name>A0A1H5W406_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94215">
        <property type="protein sequence ID" value="SEF94215"/>
        <property type="gene ID" value="SAMN04489712_102580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF94215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="32928" checksum="0E943B4B57918A9F" modified="2017-01-18" version="1">MTDQLLKEAFQRIADRAQPVQGLAEKAMGRASRRRASRLSAAAAVAVAGAVAAPFVLFGGQPATDPANDRGSLGFPVNTPSERALARECATGGTVPNRPEPYYGKPDDYRLLTSVRAEGETVALVGTRHHFMLCLSQAGGHTEVPLPGAWMGDTAGGLWSFEGAARIDAIQYMARTGGDPVPREFRHVVVGRVKEDVARVVVTWDGGRQVDAAVRNGFFLARIDGMAVKITDRRELEDRGFGDLRELREPGDDRVRSVRAFDKQGNDVFLFHTGDGAGVRRFSSTDCPKGTKGPVNALCVGLPKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W7A6</accession>
    <name>A0A1H5W7A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95106">
        <property type="protein sequence ID" value="SEF95106"/>
        <property type="gene ID" value="SAMN04489712_102609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF95106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="312" mass="33833" checksum="4AB15720D2AFDACF" modified="2017-01-18" version="1">MRRLVTGGVAGPLVLVAVLTGGCTGGGSDIGPDSDEAGRAPAVSVAESYRILRDWAERYNKAVASGDEDDWRDLTTGALRGPMTARARTYGRLPDSERISLRNPALYVPRLDGHPKWFAAAALDDVGGAAQQVLVLFRQEKAKEPWRAAHWLVFRGAPPKLDYDGHGYAIPAADGSLPSGHAAYLSTGDQSLFRPDRFTRQARDKAKRSDAPSGWSVTTRFGPDRHPVHGLRTDDGGSLVWYAVEQRRTFKANGSGRPDTLPADVRAHLTKAQRLSATRIEATWTWLAIGYVPPQGTANVLGESVRLSDVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W7X0</accession>
    <name>A0A1H5W7X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95316">
        <property type="protein sequence ID" value="SEF95316"/>
        <property type="gene ID" value="SAMN04489712_102616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF95316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="49" mass="5344" checksum="52709BCF187F8367" modified="2017-01-18" version="1">MNGKTRTAIYLRQSGRKELTGRQRKRLRQKDNKGTGSAGGRKAGGRGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WZF3</accession>
    <name>A0A1H5WZF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-fuculose 1-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04595">
        <property type="protein sequence ID" value="SEG04595"/>
        <property type="gene ID" value="SAMN04489712_10317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="8"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG04595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="214" mass="23198" checksum="2CD215F9D46EA533" modified="2017-01-18" version="1">MLLRDERRELCEIGRKMVDTGLVLGASGNISMRRGDLVAVSPTGMRLERMTPEDCPVIDLRGAVVEGGPAPSSETPMHLAIYEATGAPAIVHTHSTYGTVVATTMTELPPIHYNTLLLGGVVKVAEYATYGTPELADNVRAAMAGGMRAALMGNHGGVTIGNDLEEAFENARLLEWLCEVYVRARSIGEPRILTEEQLRRVVERGLYAKPLAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X8J0</accession>
    <name>A0A1H5X8J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07765">
        <property type="protein sequence ID" value="SEG07765"/>
        <property type="gene ID" value="SAMN04489712_103126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLAc" evidence="2">
        <location>
            <begin position="312"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG07765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="556" mass="58664" checksum="202A4AFD03A2D62C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XB24</accession>
    <name>A0A1H5XB24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08939">
        <property type="protein sequence ID" value="SEG08939"/>
        <property type="gene ID" value="SAMN04489712_103174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289228" evidence="1">
        <location>
            <begin position="26"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="51"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="134"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG08939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="37464" checksum="883451FB770C1F61" modified="2017-01-18" version="1">MNAHKPRRRPLRPMRTRPPLAAALAAPLALALVTGGCSLQTIGAPRGDMVLTATFDDVQSLVVGHSVQISDIRVGTVTAIRLTGYRTKVTMALRDDRRIPVGTTATIAKTSLLGENYVRLDPPRGRDLRTGPFLARGAAIGQTSVQPDLEQISQRLGPLLAALGGQDLATITRESATALGGQGRRLNTLIKRTADVSDSYAAASRDLGRALDDLARIGGSLRAGQEQIDRLPGNITLATERLQDDRAQLKRAVQQLLGLARSVNSRVQARHAERLATLLRRADALLAAAVRGGQDLKVLANAVLAFLRGPSVSHSGQALLFMWIKGFLPQPGTASQAAQRQPLSKLMGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XCA1</accession>
    <name>A0A1H5XCA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, DUF2236 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09070">
        <property type="protein sequence ID" value="SEG09070"/>
        <property type="gene ID" value="SAMN04489712_103179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="38"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG09070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="33293" checksum="52834AF552811699" modified="2017-01-18" version="1">MTVTESADVETRKPAGPPEPVPFGPGSILWDQIGLYASALGGNCAFILQAMHPAIGTVVDQLSSFRTDPVGRAARSFASVQTWVYGGQAALEEGRRLRTMHKPLSAVDEQGRRHHALAADAWAWVHLTGFYAAVAASRYFSPRPPTPEEEQQVFEEFLNLGRILQVPERMFPATIADYWTYFDDMVANTLVPHKVALEVLDRMDKVPPTVPAALRPALTPVSLAGGRLARLVTVGTLPPGAREKLGLSWSAADERRLRAIGAVIGRTTPLLPERVRYMPIAYRARQAARAQERLERALANRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XGN4</accession>
    <name>A0A1H5XGN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase family M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10356">
        <property type="protein sequence ID" value="SEG10356"/>
        <property type="gene ID" value="SAMN04489712_103226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="229"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG10356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="404" mass="43347" checksum="2BF5B7096EB1EE73" modified="2017-01-18" version="1">MPPERFLRPVPTTSRPDEYRLRATVEELATIERPPCSAGEREAAHLIAHRLRMLGCRARVEEEPAFGSYARPVGALAALGALAGLAGGRSRTLGVLGGTLAAAGLADEVSYGRQLARRVVSRRLSACNVVAELGDPRARRTLVVMAHHDAAPSGAIFDQRPARWFARRFPTVVDGMTENPPLWWAALAGPVLAGLGSATGSARMRRTGTVLSAATTAVMADIAARRAVPGANDNLSGVAVLIALAEALRERPPAGLRVVLFSAGAEEALQEGVRGFARRYFPRLPRETTWFLNLDTVGSGNLVMLDAEGPLRMEPYNAAFGDLVARCALEQGVRLRRGLRSRNSTDGVVPNRYGYPTVCVVSVDDEKLLPHYHLPSDLPEHVDYGCVADAARLTEAVVRALADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XIB6</accession>
    <name>A0A1H5XIB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR02452 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11363">
        <property type="protein sequence ID" value="SEG11363"/>
        <property type="gene ID" value="SAMN04489712_103264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="DUF2263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014899">
        <property type="entry name" value="UCP014899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02452">
        <property type="entry name" value="TIGR02452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2263" evidence="1">
        <location>
            <begin position="10"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG11363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="277" mass="29613" checksum="FFD12BD5ED718414" modified="2017-01-18" version="1">MSRNPRKAIAAETVAILDRGTYTAPSGREISIADRLGRAVRETRLYRPDELAALVAAAAGTGGETTRIEVTEETTLDAARRLTALAGDEVACLNFASAKNPGGGFLRGAHAQEEGLARSSGLYSSLRVFPEFYALHREQGDLLYSDHLIYSPGVPVFRDDSGRLLDEPYHVAFLTSPAPNRGAIRDPQAAARVGEVLRERAAKVLAAARHHGHRRLVLGAWGCGVFGNDPVEVAGIFADLLLDGGAFAGCFEYVVFAVWDTAPGAPRHRAFAEAFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XMM7</accession>
    <name>A0A1H5XMM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13024">
        <property type="protein sequence ID" value="SEG13024"/>
        <property type="gene ID" value="SAMN04489712_103325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="4"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="571"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG13024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1444" mass="153603" checksum="3E58DF7D9A41D3B2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XWD9</accession>
    <name>A0A1H5XWD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16011">
        <property type="protein sequence ID" value="SEG16011"/>
        <property type="gene ID" value="SAMN04489712_103439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG16011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="76" mass="8107" checksum="78C8B59768E36C6B" modified="2017-01-18" version="1">MTGALAPTKPLTAADRCDRCGAQAYVRAVLVGGGDLLFCAHHGRKYSESLRASGADIHDETDRLKATPATVHNDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YIY5</accession>
    <name>A0A1H5YIY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24061">
        <property type="protein sequence ID" value="SEG24061"/>
        <property type="gene ID" value="SAMN04489712_10441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="218"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG24061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="34045" checksum="206D75407FF489AC" modified="2017-01-18" version="1">MAVRRFVIVGYDAAELLDIACVTSSLIGANLHGAAPPYEVCLATPGGHPITCASGLTLQAQEALERITGPLDTLMVSGGIGHEAAAADRLIVAHVRRLARESRRVASVCTGAWILAAAGLLNGRRVTTHWREAQDLAVRHPEVVVDADPIFIRDGNVATAAGVTSALDLTLAFIEEDHGVETARWVARHLVTYLQRPGNQAQMSMFTAAPPPSDGLVRQIVDHITAHLDADLSTAGLAALAGVSERHLTRLFLKHLGRTPGRFVRQARTEAAAHLLASTTLPMTGVAARCGFGTTETLRQAFVAHYGIPPSQYRLTQSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YKY3</accession>
    <name>A0A1H5YKY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24255">
        <property type="protein sequence ID" value="SEG24255"/>
        <property type="gene ID" value="SAMN04489712_10449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="9"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="129"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG24255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="508" mass="56736" checksum="B03C36F1D3FA26EE" modified="2017-01-18" version="1">MSTPETRRLVAKLWNYCDVLRDDGVSTIDYVEQLTFLLFLKMGHERANRKSFPDLALKPVGDAWQSLLDADGQELEDTYNHVLREFGQRKDTLGVIFRKAQNRIQDPAKLKKLIADLIGKEQWSSQGVDVKGDAYEELLAKGAEDVKSGAGQYFTPRELIAAMVDCVRPGPDDTVCDPACGTGGFLLGAYDYIQRHHSGDLTPEQRDRLAGGGISGVELVDGTARLAAMNMLLHGIGKPTGRSLIEVRDALAEPSHLYPSVVLANPPFGRKSSITVVGEDGRAGREDIEYTRQDFWVTTKNKQLNFVQHIASMLGIPGRAAVVLPDNVLFEGGAGETIRRRLLKQFDVHTLLRLPTGIFYAGGVKANVLFFDKKPARPDVPWTSTLWVYDFRTGQHFTLKQNRLTRAHLDDFVTCYRPGEPHHTREETERFKPFTYDELIARDKVNLDITWLKDPSLEDADSLLPPDVIAREIVEDLTAALAEFTAIAEALEQTKDRPGDPDQPPEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YL19</accession>
    <name>A0A1H5YL19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24831">
        <property type="protein sequence ID" value="SEG24831"/>
        <property type="gene ID" value="SAMN04489712_10474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG24831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="15418" checksum="FC302439CA4CE849" modified="2017-01-18" version="1">MEAVPTTPDRTCTPARSGLRTGRWRMPRGQTAAAYTRRLIPGVLRGWGLGPVAGQVVPLIEELVARAAARGHGPIDVRLEFRKSIHLLLGEIRDVLPAPSEPGNLTPSREDGHSAHATAVAITYGRRPGPGGIAAWYAHCFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YL37</accession>
    <name>A0A1H5YL37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24362">
        <property type="protein sequence ID" value="SEG24362"/>
        <property type="gene ID" value="SAMN04489712_10454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="58"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG24362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="298" mass="32120" checksum="516DA8383B673F7D" modified="2017-01-18" version="1">MNELCAPLDVGDTGAVIPTASLLPAEVAAAERAALASAAFDGPRQRPDGTRTTIRGQHTIIKVQHRRHERLETMLRLERMRQEAGVRAPRLLDHGTVPTPEGQAWWVVHTFHDGQPGDRPTAAQQRALGDQLRRWHDHGPAGGLRLDGPGALGVLLGTARRLAPGAYAEISKRFDDACRGRRMTAIHGDLAVGHNVLFQGDELVAVLDPGAVDIGPPMLDLAWAMAVDLPHGAAPGPLLDGYGPIDSEALDVVLPLMMLRRLIDTFDEDGPNDGPWLTGWLDQHSPELLDLVPSVPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YPU0</accession>
    <name>A0A1H5YPU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26133">
        <property type="protein sequence ID" value="SEG26133"/>
        <property type="gene ID" value="SAMN04489712_104120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG26133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="30405" checksum="356D6BD2F3B6EBE6" modified="2017-01-18" version="1">MDREWVLWHISELGVLVPLRLGDGEPKYLNGEAADFDSTRFLADCLSFDHDLPTVVLPFFEQSHLHAPYEPIGSHVPWRNSGQGYLEVLQMAADQVTQLRFSDPLQVRYSEEGDPLTRFKQRFDGKGEPLGLYAMAIRQVDVLAEYLFLYRIAEWADRKNGKTFIGMYLDLIHDYDFGELWTISPPIGPAADQPEINVFDVYREQALGRIESLRTAGVDVADWLYGFRNRLAHGKEGIMVREFGMDADAVAADLPLLKLLARIAIESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YTP7</accession>
    <name>A0A1H5YTP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27200">
        <property type="protein sequence ID" value="SEG27200"/>
        <property type="gene ID" value="SAMN04489712_104167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG27200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="18552" checksum="A716BA4D5FB54520" modified="2017-01-18" version="1">MPYRVTFVCTGNICRSPMAEWILRHHVAEAGLDVEVDSSGTDGWHVGDDADHRTVRTLTQGGYRSAHQARQFEAAWFDHYDLIIALDRGHLRELRAMAPDAAARDKIRLLREFDPDAGGELDVPDPYYGGRTDFEHVRELIEAAVPGLLDEVGNALKDRDGLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z6C1</accession>
    <name>A0A1H5Z6C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32099">
        <property type="protein sequence ID" value="SEG32099"/>
        <property type="gene ID" value="SAMN04489712_104393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="40"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="137"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG32099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="499" mass="53065" checksum="A01102FD91E6D503" modified="2017-01-18" version="1">MILKRGVKIQLLVFALITVLGVSVVAVRYIGIGRGLLGNQYTAYVDLTDSGGVFTNAEVTYRGVTVGRVGPMELTKTGIKVKLLMNSDRKIPWDGTIAVVGNRSAVGEQYIDLQPTKKPGPGGEPAGPYLGDGGRYDTIPADRTRLPVSTAELLRNVDKLISSVNPQHLRVIVDELDKAFNGSAADLQAILDDSDRLLKTAEEAYPDTSELLHNSRTVLDTQRQMGGHIHEFARNLNVLTGQLRRDDPALRATLDATVPASAEATRLIEQLSPTLPVLLANLTTTGQIMTSRIAGIRSLFILYPLTVAGAFTVTPGDGTQHLGLVLNLDSPAPCTTGYEQVKRRWPQFTEKRETPLNLGCKEPKNSDKVIRGARNTPPEARQPYPRVPQGATEGAGFPEGGATGTAGSGEAANAQGSEGTGRPAADKKTGEQGGLTTLSGNSLYVPVSSGSVELAGYDPSTGAVYGPDGKRYLLGYSGGQERLLGDSSWKMLLLGPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z7V2</accession>
    <name>A0A1H5Z7V2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplB</name>
        <name evidence="7" type="ORF">SAMN04489712_104409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32431">
        <property type="protein sequence ID" value="SEG32431"/>
        <property type="gene ID" value="SAMN04489712_104409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG32431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="277" mass="30534" checksum="227A07AF3DCF910B" modified="2017-01-18" version="1">MGIRKYKPTTPGRRGSSVADFVELTRREPEKSLLRPLPKKGGRNNHGRITTRHQGGGHKRAYRLIDFRRADKDGIPAKVAHIEYDPNRTARIALLHYVDGEKRYILAPQGLKQGDRVENGPGSDIKPGNCLPLRNIPTGTVVHAIELRPGGGAKLARSAGAGCQLLAKEGKYATLRMPSGEMRMVDVRCRATVGEVGNAEQSNINWGKAGRMRWKNKRPTVRGVAMNPIDHPHGGGEGKTSGGRHPVNPKGKKEGRTRQANKASDRLIVRRRSKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A8X5</accession>
    <name>A0A1H6A8X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative peptidoglycan binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45189">
        <property type="protein sequence ID" value="SEG45189"/>
        <property type="gene ID" value="SAMN04489712_105290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="185"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG45189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="245" mass="26745" checksum="4A9E4EF50818AB66" modified="2017-01-18" version="1">MEFERRSVFGWGATPAPFAPCDAGLVVHYDGSNQGLASKPHSACRRYWDQTRDFHMRANGWIDVGYGFAVCPHSIVMEGRGWQRAQAAQPGGNTTWTSVTFMSGPGEDPTAGQIRAFKELRAWLRGKGLGSGIRGHRDFISTSCPGDRLYRLVRDGTLTGAPAKNWTEDMVKKLPTLGKGAKPSEDMQTLRSLLLARSHPEVGGIEGGFDATVERAVKAVQEWGGIEADGIVGPKTWPVLLRVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AAM2</accession>
    <name>A0A1H6AAM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45234">
        <property type="protein sequence ID" value="SEG45234"/>
        <property type="gene ID" value="SAMN04489712_105292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG45234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="24380" checksum="C5C5407A540E4BB2" modified="2017-01-18" version="1">MSEPTTRHQKAGAIITAGMIVILVVWALAAGRDESAAPPPVDLPLITSPTPSPTETALTALSDRERAFLEEMGEEEPYTSEHKGTLGNGWYACTGDDRDYLAGDEFPDVDGPPTAKILRDNPDESLYEAAITHLCPKYLPLLKKEQKRLEGSFEDGTWEVGEDIKPGTYRTDGGVTDCYWERSTGGGDTIDNNFVTNAPKGVTVTIAPSDGGFTSRDCGLWLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AAX1</accession>
    <name>A0A1H6AAX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, Lrp family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_105330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45893">
        <property type="protein sequence ID" value="SEG45893"/>
        <property type="gene ID" value="SAMN04489712_105330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG45893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="211" mass="21777" checksum="7FC4B6AE80378418" modified="2017-01-18" version="1">MPIDELDGRVIELFTAEPRIGVLEASRRLGVARGTVQARLDRLARDGVIRGYGPQVDPGALGYGVTAFVTLQIRQPGGHDPVAERLAAIPEVIEAHTITGAGDMLCRIVARSNADLQRVIDLVVAVSGVERASSVISLATQIPFRTLPLVRAVSGTDGGDGGGGQGGSGGGRDGRGGGERPEHAGRPAGEVRRRVVRDARSGSVGSPQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABJ7</accession>
    <name>A0A1H6ABJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="4" type="ORF">SAMN04489712_105301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45417">
        <property type="protein sequence ID" value="SEG45417"/>
        <property type="gene ID" value="SAMN04489712_105301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG45417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="76" mass="8371" checksum="18F85E9D8B4684DD" modified="2017-01-18" version="1">MTDDNRPSYEQARDELADVVRRLEAGGLTLEESLNLWERGEKLAEICEEWLEGARARLAAAMAEPGNGAGPEPTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADS3</accession>
    <name>A0A1H6ADS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46631">
        <property type="protein sequence ID" value="SEG46631"/>
        <property type="gene ID" value="SAMN04489712_105374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="26707" checksum="F85A5EE19CFC09A2" modified="2017-01-18" version="1">MTTLRSVTDLRTPPVNDGDLFSARARQYACEHRGQVLQVLEAGCGWGAGLDLGDRERQVTGVDLDVPALRAHTEARTDLHAFHLGDLRTVPMPPRAYDIVHAPFLIERVPHAELVLDRIVAALRPGGLLLLRLRDRDTAFGLVDRLLPARLPVRHRSRQAAAGPPPAVYESVASRKGMQWYCMMRGLAIAEEYVSGELAAEAGRGIAGMCRLVAAFSRGRLPAGHSEVTMVVRKPENRFARVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADZ1</accession>
    <name>A0A1H6ADZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46592">
        <property type="protein sequence ID" value="SEG46592"/>
        <property type="gene ID" value="SAMN04489712_105372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292588" evidence="1">
        <location>
            <begin position="28"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="227" mass="24706" checksum="A3E86DD0203ADF68" modified="2017-01-18" version="1">MFRTTVKTALVAGVAALALTACGPVKMGSAVIIGDERITTASLDRTVQEWNEQFRASPEANMKRTGSATPGQQRLPMDAVSDSQMRDALTRIVRIRISDEVARQERIDVPADQIDQVIDQSGGPREAESTTLAMGLPGRYTRDLIRDQLIQLTLLRRHGFDGVEGSPAARQAQQRAIAVYTDVVRRLGVKVNPRYGDFDTAQLMVAPVTYRLSRGETGTGLLPGNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AE11</accession>
    <name>A0A1H6AE11_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="11" type="ORF">SAMN04489712_105373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46612">
        <property type="protein sequence ID" value="SEG46612"/>
        <property type="gene ID" value="SAMN04489712_105373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="628"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="807"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG46612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1167" mass="128862" checksum="FED39D803C209729" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AEN6</accession>
    <name>A0A1H6AEN6_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Thioredoxin reductase (NADPH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105368</name>
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        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46517">
        <property type="protein sequence ID" value="SEG46517"/>
        <property type="gene ID" value="SAMN04489712_105368"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-binding_dom"/>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG46517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="549" mass="59469" checksum="CE386262A7A075EB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AFM2</accession>
    <name>A0A1H6AFM2_9ACTN</name>
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        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_105370</name>
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    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46556">
        <property type="protein sequence ID" value="SEG46556"/>
        <property type="gene ID" value="SAMN04489712_105370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292640" description="Peptidoglycan glycosyltransferase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="670"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG46556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="768" mass="82680" checksum="DB3FD2767695BF91" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AH00</accession>
    <name>A0A1H6AH00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48049">
        <property type="protein sequence ID" value="SEG48049"/>
        <property type="gene ID" value="SAMN04489712_105454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292763" evidence="2">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG48049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="14234" checksum="AAAAF53EC38A8DDB" modified="2017-01-18" version="1">MRVALSVAVLGLTAGLLSACGGDGDEPDDAQASSSPAATAPATQQPAEQANGLAGTWKPINKSPIATLTITGTTAQTTGELACPGTITGADSAKPTLTLDCTTPNEDRKRGTLKLKPDGSALVITWDGPAWGGMIDSMKRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AHE1</accession>
    <name>A0A1H6AHE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48183">
        <property type="protein sequence ID" value="SEG48183"/>
        <property type="gene ID" value="SAMN04489712_105461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG48183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="233" mass="24584" checksum="13A71EA88E12814F" modified="2017-01-18" version="1">MTGSESGIAWVRIEGSGPHNLLDVGALSALTRKLAPFLDAPPAAVMLHGGESFSAGADLTELGRMTAEEFAGLLDAELDLYELVERLPCPTVAVIRKWCQGSAAELALACDMRIAGESARFCLPEVAAGFPAPVHRLAQLVLPGVATELVLTGRRMGAGEAAKAGLYTQVVPDAELDAAARRLAERLAGLPSPAAVATTKAWLRQARAGEPFDRADLRARATSIFSDWLDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZG6</accession>
    <name>A0A1H6AZG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53782">
        <property type="protein sequence ID" value="SEG53782"/>
        <property type="gene ID" value="SAMN04489712_106116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="7081" checksum="1D94D0CE18A28AC7" modified="2017-01-18" version="1">MRIGGLAALVGVSTRTVRHYHHLGLVPGQVRRILGFDVKGMVSLVLWVARTRIRGHRCLAVLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B0Y8</accession>
    <name>A0A1H6B0Y8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54513">
        <property type="protein sequence ID" value="SEG54513"/>
        <property type="gene ID" value="SAMN04489712_106162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="86"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG54513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="373" mass="39789" checksum="C258916B1D2894EE" modified="2017-01-18" version="1">MDVQSLPLIDHHCHGLVREDLDRAGFEGRLTEGDGGGPLGGTLFDSHIGLAVRRWCAPVLGLPAHAPPDDYLERRADLGADEVNRRLLRAAGLEALCVDTGVSGPLLSPAELGEAANARAHEVVRLEQVAEQVAAAGGTAVGFADAFRARLDERARDAVGFKSIAAYRTGLALPGDRPDEAEVTAAAGRLLGSAGPPRVADETLHAFLVWCAAEYGRPIQFHVGYGDNDLRLDRADPLLLTDLLRALASTGAPVMLLHNYPFHREAGYLAQVFPNVFVDVSLAVHSVGRRAGAVICEALELVPFGKFLYASDAYLLPELYHLSAVLFRCALGGLLDDGVADGSWTADDAARIARLITTENARRVYRLPAPADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B1A4</accession>
    <name>A0A1H6B1A4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neocarzinostatin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_106169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neocarzinostatin family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54631">
        <property type="protein sequence ID" value="SEG54631"/>
        <property type="gene ID" value="SAMN04489712_106169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027273">
        <property type="entry name" value="Neocarzinostatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002186">
        <property type="entry name" value="Neocarzinostatin_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00960">
        <property type="entry name" value="Neocarzinostat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49319">
        <property type="entry name" value="SSF49319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293240" evidence="5">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG54631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="198" mass="19819" checksum="F98EF872671B13E9" modified="2017-01-18" version="1">MITIVLAALALSPLTAPAVPADRAAAPALRISRVADLAEGEEITVTGTGFRPGLKSVAVGLCREGYTNGLKDCDLGGGATFVNIDAHGAFPTVRLKARSKFNGIDCMTRQCVIGAAPLPTTNPPAIVNANTAIVRVGFKGSQFKGGATPAAAAPQAAAGPDTGGPSTPLWAATLGVLVLAGAAVAAAQRRSQHPRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B7D2</accession>
    <name>A0A1H6B7D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56295">
        <property type="protein sequence ID" value="SEG56295"/>
        <property type="gene ID" value="SAMN04489712_106301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="27866" checksum="87DEDC6ED2A74C9C" modified="2017-01-18" version="1">MRIGELAALVGVSTRTVRHYHHLGLLPEPERLANGYREYRLRDAVALARVRRLAELGLSLDEIRDVLADDRGRELREVLLELDADLARQQRAIEARRKRLAALLAETSLHPDSTVSPDMAAVLRGLSTEGSTFAEFDRGLLALADTGADPADRAEFVELLRPFTEPAVSEQGRALYARLDEIADAGVGDPRVAALADDVAAYIPDEMASVMIGSLEDPATDHWMEAMWEELSAAQAEVFRLVVIMLKERVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BE80</accession>
    <name>A0A1H6BE80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58567">
        <property type="protein sequence ID" value="SEG58567"/>
        <property type="gene ID" value="SAMN04489712_1071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG58567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="213" mass="22554" checksum="5727373EB2E3C224" modified="2017-01-18" version="1" fragment="single">MFGVVRPCRHVMCGSLFKEWMAHMCGLCLTLRAEHGQAARLVTNYDGLLVSVLAEAQNPERSPHRKAGPCALRGMRSADVVDARSEGARLAAAVSLLLAAAKTRDHIVDRDKAYGRKLVAVGAGHMADRWDAAGARTGSALGFDASVLRKAVERQARLEAVGGLGLLELTEPTETAVAAAFAHTAVLAGKPHNVEALGEAGRFFGRLAHLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BIB1</accession>
    <name>A0A1H6BIB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc uptake regulator, Fur family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60332">
        <property type="protein sequence ID" value="SEG60332"/>
        <property type="gene ID" value="SAMN04489712_107124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG60332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="14831" checksum="3721C37AE7505747" modified="2017-01-18" version="1">MMARRDGTGARTTARRDAVREVLARSEGFRSAQDIYADLRADGSKIGLTTVYRALQAMSEAGQVDVLRTDEGEAVYRACHTDEHHHHLVCRRCGRTVEVAGPAVERWAETIGAEHGFTDVTHTVEVFGTCAGCAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYD2</accession>
    <name>A0A1H6BYD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase, MSMEG_4879 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65445">
        <property type="protein sequence ID" value="SEG65445"/>
        <property type="gene ID" value="SAMN04489712_108106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019910">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_4879"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03564">
        <property type="entry name" value="F420_MSMEG_4879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="302" mass="31438" checksum="C6B046628D429ABB" modified="2017-01-18" version="1">MRLGVHIVDAGSGLEEIVGRVRAAADAGFAGAYFGQLTSWDAVGLAALAGREVPGIEVGTAVTQTWPRHPLALAGQALTAQAATGGRFTLGVGPSHPQIVEGLFGLPYERPARHVREYLTALMPLLRGEPVDFHGETLTAAGRVEVPVPRPPSVLLSALGPVMLRIAGELADGTVTVWTGPESIADHVVPAITRAAAQAGRPDPRIVATVVVSVTADPEGVLQQTVEQLGMAADLPAYRATLDRQGLTGVHETVVAGDEGTVERALRAYADAGATELIVSAHGDERDRARTLEFLASLADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C0C7</accession>
    <name>A0A1H6C0C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66411">
        <property type="protein sequence ID" value="SEG66411"/>
        <property type="gene ID" value="SAMN04489712_108190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021441">
        <property type="entry name" value="DUF3090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11290">
        <property type="entry name" value="DUF3090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03847">
        <property type="entry name" value="TIGR03847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG66411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="20017" checksum="1C419EE9EA4BC60B" modified="2017-01-18" version="1">MPVISYDMPDRFVAGAVGQPGERAFYLQARAGRRVTSVGLEKFQVTMLAERLEELLDEVLRRSGGSAPVPAVAPTELQDDAPLDQPVEEEFRVGTMALAWDPEDERVIIEAQEVTDDEGVEPLAAEPGEDEPAIVVLRVRITAGQARAFAERALKVVSAGRPPCPLCGLPLDAAGHVCPRQNGHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1D7</accession>
    <name>A0A1H6C1D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66810">
        <property type="protein sequence ID" value="SEG66810"/>
        <property type="gene ID" value="SAMN04489712_108226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="11013" checksum="710CBDC8D7007F00" modified="2017-01-18" version="1">MSERRRTVTSNAGYRWSRRFANVTGVGWAQVFVGVAFAGLVVLAVCSVKVFRALRTLGRELERARRRIEPKQSALSGELRRLRDAQEAEHVPDGVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1M2</accession>
    <name>A0A1H6C1M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-3' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66861">
        <property type="protein sequence ID" value="SEG66861"/>
        <property type="gene ID" value="SAMN04489712_108231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="12"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG66861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="319" mass="33440" checksum="7D749C0DBA112C45" modified="2017-01-18" version="1">MSPARGTMASMSALMLLDTPSLYFRAFFGVPESVTAPDGTPVNAVRGLIDMIARLVRDRSPARLVCCMDADWRPAFRVAALPSYKAHRVADDGGDQTPDPLAAQLPVIDAVLDAAGLVRAGVPGYEADDVIGTLTARHAAAGGAVDIVTGDRDLFQLVDERGPVQVLYTARGIRNLQVMGEKEVAAKYGIPGRAYGDYATLRGDPSDGLPGVPGVGDKTAAALVTRFGSIAGILDALDAGATEGFPAGSRRRLEAARDYLAAAETVVKVVTDIDAPELAALDDTLPRAPRDPRALAELAERWNLGSPVKRLQDALAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C379</accession>
    <name>A0A1H6C379_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67460">
        <property type="protein sequence ID" value="SEG67460"/>
        <property type="gene ID" value="SAMN04489712_108289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG67460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="12816" checksum="A053BA9BF1BF157D" modified="2017-01-18" version="1">MPHRNPQPNPTRRATGPRETASHLGFRIARTGATALLAAWATIPLTGALQRLPALATAAYGFVLALAGASAALGWATNLGPLRARLKDPSSQERLHTAVIVQWLLAVLVSTALAGYAARFAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C3H4</accession>
    <name>A0A1H6C3H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67514">
        <property type="protein sequence ID" value="SEG67514"/>
        <property type="gene ID" value="SAMN04489712_108295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG67514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="10559" checksum="C62B17EC7DF9D35C" modified="2017-01-18" version="1" fragment="single">MDNRSQVREFLTSRRARISPQQAGLPSYGTRRVPGLRRAEVAQLAGVSVEYYSRLERGDLSGVSDHVLDALARALRLNDAERTHLEDLARAAGPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7Y2</accession>
    <name>A0A1H6C7Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, epsilon subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69071">
        <property type="protein sequence ID" value="SEG69071"/>
        <property type="gene ID" value="SAMN04489712_10946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="211" mass="22920" checksum="2938634A26E0254B" modified="2017-01-18" version="1">MPLHPGVNPLPVRIALSSLIAMSRLPELYIAADVEADGPIPGPYSMISLGMAVVGRPDLTFYTELRPISDEFVPAALAVSGLDRDRLLREAPPAEEAMAAAAKWINGLRTIGRPVFLAGPAVWDGMYIHWYFLRFLGKSPFSASGAGIDLRSYWMGRNGCEWAASRKSDIKQKLKLTGLPHTHHALEDALELAAVFEAMLASREDTPPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CD47</accession>
    <name>A0A1H6CD47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate, water dikinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70565">
        <property type="protein sequence ID" value="SEG70565"/>
        <property type="gene ID" value="SAMN04489712_109180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="3">
        <location>
            <begin position="62"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="3">
        <location>
            <begin position="198"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="2">
        <location>
            <begin position="588"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG70565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="677" mass="70099" checksum="FAC61EAEA892BA37" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CD81</accession>
    <name>A0A1H6CD81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70941">
        <property type="protein sequence ID" value="SEG70941"/>
        <property type="gene ID" value="SAMN04489712_109223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="33739" checksum="869121DB6EBC1635" modified="2017-01-18" version="1">MAVAPIARTAHRHLDVDGVRVFYRESLPERTDAPVLLLLHGFPSASHQFRRLIDVLGASYRLVAPDYPGFGHTEVPDGFTYSFDRLADITEGFVQRLGLTRFVMYVFDFGAPVGFRLAERHPEWIAGLVVQNGNAYTEGLSDGARDFIALRPGTPGAEETIRGLLTLDGTRGQYETGVPDPALLAFDGWTLDQHFLDLPGRKEAQVALAFDYHSNLQHYDRWQSWLRKHTPPTLITWGVGDPFFPEPGARAYLRDLPDAELHLFDTGHFALETHLPEIAPLIATFLDRTWPQQPAARRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CME0</accession>
    <name>A0A1H6CME0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_110195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74164">
        <property type="protein sequence ID" value="SEG74164"/>
        <property type="gene ID" value="SAMN04489712_110195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG74164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="27195" checksum="86BEF5299D7EC86C" modified="2017-01-18" version="1">MTGAILAARGLAKEFRGFRAVDGVDLDVAEGSVHALVGPNGAGKTTLFNLLTGFLPPTAGTITLGRRDLTGRRPEEVARAGLARSFQITSLFPQMTVRRHLELALAGPTGLGWRFWRSDKALRRFAGRADELLDQVGLLGFADQAAGTLAYGRKRALELALALSLDPKVLLLDEPTAGMGAEDVDRTVELVRRVRTGRTVVMVEHNMNVVASLADRVTVLQAGRVLVEGPYAEIRHDPRVISAYLGDPDAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CP14</accession>
    <name>A0A1H6CP14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_110226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74433">
        <property type="protein sequence ID" value="SEG74433"/>
        <property type="gene ID" value="SAMN04489712_110226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG74433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="32496" checksum="6B2DB06C908435FE" modified="2017-01-18" version="1">MTTRQEVHQVAAAAPAPAAGPDPRRGRPRRPPLPRPANPLAALGALAWLVVVGLPVYYLVTVSLRTRAEYLTAGPLAPPTSPTLDNYRLVLTGEFGRYFLNTAVITVVSIVLVLALALPAAYAVVRGRHPLLRTGFSMLLLGLAIPSQAVIVPIYLLITRLHLYDSLTGIIVPTVAFGLPVAVLVLTSTLRDVPEELYEALALDGGGPVQALRTLAIPLSRPGLVTVAVYVAVNAWNGFLFPLVLTQSQDQRVLTMGLWSLQGQYTSNVPALMAAMTLSVLPVLLFYAFGRRRLVGGLTAGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQG4</accession>
    <name>A0A1H6CQG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase, Mutator family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75232">
        <property type="protein sequence ID" value="SEG75232"/>
        <property type="gene ID" value="SAMN04489712_1111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG75232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="89" mass="9143" checksum="B1C47A800F5BDC3C" modified="2017-01-18" version="1" fragment="single">MTNHDEDEPQGGLDVQLAAELVAKAKAEGVSLVGPDGLLAGITKTVLQAALEAEMTEHLGYERGEHPAAPTGNHRNGSSAKTVSTEVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQT2</accession>
    <name>A0A1H6CQT2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75331">
        <property type="protein sequence ID" value="SEG75331"/>
        <property type="gene ID" value="SAMN04489712_11119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="5">
        <location>
            <begin position="18"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG75331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="557" mass="63254" checksum="92101111219818E9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUM5</accession>
    <name>A0A1H6CUM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_111191</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76662">
        <property type="protein sequence ID" value="SEG76662"/>
        <property type="gene ID" value="SAMN04489712_111191"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="2"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="195"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="9">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG76662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="32775" checksum="45C32227618CAE65" modified="2017-01-18" version="1">MRYAYLGPQGTFTEAALNSVPEAAGAEHLPYATVPAALDALRRGEVEAAVVALENSVEGSVPTTLDELATGQPLQIVGEVHLPVSFALLVRPGTTFGDIKTVASHPHAQPQCRRWLAAHVPDAEWRAATSNAEAAQHVADGHYDAALAGSFAAARYGLSVLAEDIHDVADAVTRFVVLRRPCPPPPPTGMDRTTVVAFIGEDHPGALLEILNEFSMRGINLTLIQSRPTGQGLGSYLFWMDFEGHVADARVGEALMGLRRICADVRFVGSYTRADRIRPQIRRGTHDTDFTEAAAWLTAIRSGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVP0</accession>
    <name>A0A1H6CVP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator, OmpR family, contains REC and winged-helix (WHTH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_111182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76585">
        <property type="protein sequence ID" value="SEG76585"/>
        <property type="gene ID" value="SAMN04489712_111182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG76585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="26276" checksum="F62E2B8C7DD62ABC" modified="2017-01-18" version="1">MNEEITGRILVVDDDPTVAEVVMRYLVRDGHEVRCVADGHEALASVRAQPPDLVVLDLMLPGVSGLEICRRLRENSAVPIVMLTALGEETDRLAGLETGADDYVTKPFSPRELALRVRSVLRRAHGGLAPAGRGPARLGDGELVVDTGAHEAFLGGRRLALTAREFDLLAFLMRHPRRAFTRGELLEQVWGWSFGDSSTVTVHVRRLREKIERDPTVPHRIVTVWGVGYRYEPGSADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYR7</accession>
    <name>A0A1H6CYR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78200">
        <property type="protein sequence ID" value="SEG78200"/>
        <property type="gene ID" value="SAMN04489712_11245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="14"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="5">
        <location>
            <begin position="180"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG78200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="31571" checksum="0925187C60C99F05" modified="2017-01-18" version="1">MGRGSVEVGGVVETVGFVGLGVMGQPMALNLARAGVPLIVFNRTASRCAPVTAAGARRAADPGEVFEHAGVVLLMLADEGAVDAVLGRGTPAFAARVRGSTMVQMGTVAAAYSQKLAEDVTAAGGAYVEAPVSGSRGPAEAGELVAMLAGDEDAVERVRPLLGPVCAETFVCGPVPSALVMKFAVNLFLITMVTGLAESFHFAEEHEVDAALLERVLDAGPMASAVSRTKARKLVRGDFEVQAAIADVLKNNRLVAEAARSRGAASPLLDVCHALYGETLDLGHGGADMAAVIHALRARTSRGERGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZJ0</accession>
    <name>A0A1H6CZJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78188">
        <property type="protein sequence ID" value="SEG78188"/>
        <property type="gene ID" value="SAMN04489712_11243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="21351" checksum="EA85821396D46C7E" modified="2017-01-18" version="1">MPEPRRSVLAVAVLSMLAEEPMHAYRMQQLIKERHKDDVVNVSQRNSVYQTVQRLVRDGLAEVAATERADNRPERTSYRITATGRATLDEWLRTMLSTPAREYTEFPAALAFLPNLAPRDAAAALTARITRLEARAAALDAEIAQVRSFLPRLFAIESEYQQQVIAAELAYVRGIVEDLRTGEITWPSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZL9</accession>
    <name>A0A1H6CZL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar diacid utilization regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78502">
        <property type="protein sequence ID" value="SEG78502"/>
        <property type="gene ID" value="SAMN04489712_11285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="192"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="310"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG78502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="379" mass="40435" checksum="6FCB73E1D5F179A6" modified="2017-01-18" version="1">MSDYQSVVDEVSALLRAPVTLEDREFALIAFSSHDDDLDPVLDPVRTRSILRRRSSPAVRAWFEGFGIARATGPVRTPADPAAGVRARLCLPARHEGVVYGYLWLLDDGAVDPADPRLTRAMALAARAGRLLAADTWRGEAAPRAFAQLLSGSAADRAEGARTLGALEHPASMSASVAVVWASPVPDFVPARLPYGVLAHRTPGGLALLVPLPDPADIAPARTIAAGLLDPAAGSHRSLAGVGGARTELPEVPHSWREARLAVRAARAEPRLGPVASWNELGAYRLIAAPPTMHADPALLPLLDPARADLLRTAETYLDHAGHVQRAAAALSVHRQTLYYRLSRIEALTGLDLTSGTDRLLLHLAIKTFRLTTAPEDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5U2</accession>
    <name>A0A1H6D5U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80153">
        <property type="protein sequence ID" value="SEG80153"/>
        <property type="gene ID" value="SAMN04489712_11327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="25468" checksum="D3108EB220D35424" modified="2017-01-18" version="1">MATYVLIPGAGGESWYWHRVVPLLRARGHDVVAPDLPADDDSAGFAEYTDVVVDAIGDRTGLVVVGQSMGGFVAPMVCARVPVDLMVLVAAMVPVPGESGGQWWANTGQERAMRQMAEREGRALGEGFDPRDVFFHDVPPDVTAEAMKGGRRQSDTPFEKPWPLDAWPDVPTRFLLCRHDRLFPAEFQRRVVRERLGIVPDEIDSGHLPALARPEALAERLEAYRAEALTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D798</accession>
    <name>A0A1H6D798_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81287">
        <property type="protein sequence ID" value="SEG81287"/>
        <property type="gene ID" value="SAMN04489712_11417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="16"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="169" mass="17897" checksum="BA57FC09E6B553C2" modified="2017-01-18" version="1">MSRERRGTERTRSHPEQRLGELGLTLPEAVPPVATYVPAVRSGDHVHVSGQVPLREGRLIAAGRLGDTVSVELGYECARQCALNALAALKAEIGDLAAVARVVKAVVYVASTADFTRHPQVGDGASDLLCELFGDAGRHARSAVGVLTLPLSAPVELELLVELHRPARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAL4</accession>
    <name>A0A1H6DAL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82371">
        <property type="protein sequence ID" value="SEG82371"/>
        <property type="gene ID" value="SAMN04489712_11516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG82371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="175" mass="19153" checksum="9882DFEA681FD7D2" modified="2017-01-18" version="1">MTFEEFIIARLPALLRFATALTGDPHRAEDVVQDALVKAQRRWRRIAGTQAPEAYLKRMITNEYLSWRRRRSSGEVPVTDGTLAAAGGPAADSADHHADRHVLWAMVRALAPKQRAALVLRYYEDLSYAEISGVLGCSEATARSHVSHALTILRVDVAGQSPDAAPLSRPAAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCA8</accession>
    <name>A0A1H6DCA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82315">
        <property type="protein sequence ID" value="SEG82315"/>
        <property type="gene ID" value="SAMN04489712_1158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="15236" checksum="9EACB33B752EE0DF" modified="2017-01-18" version="1">MLPGAETSDHRICWRFTHVDHEGPWGFDKVEPETLRWLFDRLGQLETMTVNEIFNRGDYPGKDYDVETIPNVEALDRLEQIGLADMTKIWCLRLQGEPRLYGFLHGHVFHIVWWDPKHEIWPSRLKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCE7</accession>
    <name>A0A1H6DCE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, CP family, cyanate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82802">
        <property type="protein sequence ID" value="SEG82802"/>
        <property type="gene ID" value="SAMN04489712_11587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="12"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG82802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="490" mass="49809" checksum="152DFD3E0FC621F7" modified="2017-01-18" version="1">MSSSTPRVSRSAAAWTVAGLVLLALNLRAAITGVSPLLDDLQHALGLSTTAMGVLTTLPVLCLGAFAALAPPLARRVGTEVTLTGALLLIMGGILLRSAPWPGGLATAALFAGTAMAGAGIAIGNVLMPYVIKSAFPERVGLFTGLAMMLMSTGAALSSGLAVPLNELGGWRTALAVWAVPALVGVSVWAPLAVRRRAAAAVSAGTEPSASPGDSRTTPGVSPQAGKPADTVAQGAGTASDVPPQAGKPTGVVAQGAAPRGEGASGSVLRSRLAWYVTLFMGMQSLTFYVLMSWLPAIMRDHGYTAATAGLMLSVTMLLGIPTGMVMPVLAARRADQRPLVVAVMALLIGGVAGLLLAPEAGWLWTVVLGIALGAAFPLAFTLITLRSATPRAAAELSGMAQTTGYLLAGAGPFLIGVLNEATGGWRVPLAILLVWLLPETLFALRAARPGHVGTTSAADLTRIEPTEAPRPQQKVDPQDALTRTGRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCF1</accession>
    <name>A0A1H6DCF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Replicative DNA helicase</fullName>
            <ecNumber evidence="4 13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SAMN04489712_115108</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 13"/>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82929">
        <property type="protein sequence ID" value="SEG82929"/>
        <property type="gene ID" value="SAMN04489712_115108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SF4 helicase" evidence="16">
        <location>
            <begin position="185"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="15">
        <location>
            <begin position="530"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="SF4 helicase" evidence="16">
        <location>
            <begin position="673"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SEG82929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="898" mass="96767" checksum="3D326FEDFED08FF7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDA0</accession>
    <name>A0A1H6DDA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82446">
        <property type="protein sequence ID" value="SEG82446"/>
        <property type="gene ID" value="SAMN04489712_11527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295846" evidence="2">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="75" mass="8342" checksum="A4C52EFCA48E2A27" modified="2017-01-18" version="1">MKVRLAALTAMLVLAGTGLTACSSDRWCEYDATDTKVADRYCEQGTPGYEWEPDSDGKTKSKRKTKSHSKSKPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDB4</accession>
    <name>A0A1H6DDB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anion-transporting ATPase, ArsA/GET3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82725">
        <property type="protein sequence ID" value="SEG82725"/>
        <property type="gene ID" value="SAMN04489712_11572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="41987" checksum="87DEA4509DD1EDD4" modified="2017-01-18" version="1">MSVHRTPPVLDVDTLIDDPRTKIIVCCGSGGVGKTTTAAALGLRAAERGRDVVVLTVDPAKRLAQSMGLSELDNSPRRIEGVEGDGELHAMMLDMKRTFDEIVEAHSDPDRAKQILANPFYQSLSSSLSGTQEYMAMEKLGQLHRSGAWDLIVVDTPPSRNALDFLDAPERMGRFLDGRFMKILATPAKTGGRLGVKVLTAGFGVFTNVLNKVIGVQLLRDVQTFVAAFETMFGGFRERADKTYRLLQTPGTAFLVVAAPEPDALREASYFVERLAEERMPLAGLIVNRVHAVVPHTPTAARSQAAAETLDERGEHPLAAALLRLHADRRQLAAREERLREHFTSAHPAVPVASVPAQAEDVHDLEGLRQVGDDLAGNRAAATARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDZ0</accession>
    <name>A0A1H6DDZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83588">
        <property type="protein sequence ID" value="SEG83588"/>
        <property type="gene ID" value="SAMN04489712_11631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="281" mass="31287" checksum="B9384374B714F7DC" modified="2017-01-18" version="1">MATMSPILDGVTCEGAGCAARAHRSGRRTAPPRVRLCPRCRDALDAELRRLPGLYAECENRLGPSGSPVVRRPSGRVRGETPFNAAAAECRSQILGVLASWAGLTAEARRVTAPRRAVPRLSAFLRRHLDWLARHPAVGDLSVETARLVRTAERVTGADPVRRVHVGSCVETGCRGTLTAYVTPDRRRPPRITCDAEPEHSWAGGEWLNLGRRIAETAPSPPSGREPRPRRWLSPADICCLWNIPRGSVYRLASERRWRRRKVDGRTYYAEPDVRLTLRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE82</accession>
    <name>A0A1H6DE82_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 6">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 6"/>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83688">
        <property type="protein sequence ID" value="SEG83688"/>
        <property type="gene ID" value="SAMN04489712_11649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="6"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG83688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="323" mass="36275" checksum="C96DBF8F533C7C0B" modified="2017-01-18" version="1">MATRILVTGGAGFIGSHYVRSLLKARDDVSVTVLDKLTYAGNRANLGPVRGERRFRFVRGDICDPDVVDALVREADQVVHFAAESHVDRSIYDADRFLRTNILGTQVLLEAALRHELERFVHISTDEVYGSLERGSWSEAEPVRPNSPYAASKASSDLIALSYHATHGLDVRVTRCCNNYGPYQFPEKVIPLFVTNLLTGRKAPLYGDGSNVREWLHTDDHVRAVELVRTRGAAGEIYNIGSDTELTNRELTAVLLEGCGAGWDMVEMVADRPGHDLRYSVDWAKARTQLGYSPRRDFAAGIAETIEWYRRNRDWWEPLKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEV1</accession>
    <name>A0A1H6DEV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_116111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83957">
        <property type="protein sequence ID" value="SEG83957"/>
        <property type="gene ID" value="SAMN04489712_116111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025510">
        <property type="entry name" value="DUF4397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14344">
        <property type="entry name" value="DUF4397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295800" description="DUF4397 domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4397" evidence="3">
        <location>
            <begin position="50"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG83957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="292" mass="29150" checksum="5C452666F7CAC5B6" modified="2017-01-18" version="1">MMREPAKTHRSGAAVLTAVTLGMITAAAPATATTSASRPGAPGVSAQGTATVSVLHGVPGATVDVYANGKKLLSNFTPGSLSSPQKLPAGSYDIKVLKAGENPGATPLVSKTVQVADGSNDTITAHLNEGGQPAITAFVNDTSKVPAGKARLTLRHIAAAPAVDVRADGKPVVRNLANPGQAELEVPAKKVRADVVLAGTGNVVAGPADLNPSEGSDTIVYAWGSARDKNIKLAVQSIKGMQTAPGRVPAGSGGQAAGPDGGAPGWMYGLTGLAMLVVVGAGSRLLILRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF00</accession>
    <name>A0A1H6DF00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83879">
        <property type="protein sequence ID" value="SEG83879"/>
        <property type="gene ID" value="SAMN04489712_11690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="58"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14309" checksum="78C2508045B8E70E" modified="2017-01-18" version="1">MDATPGIPPAVTEETGPFWAAAREGRLVVEQCASCGAESFPPRGICRSCRGRTMVHAEITGRGTVYSLTVNHQRWLPGLQVPYAIVLVEFPGHPGVRVAGRLRGCPPEEAAIGMTVDIGFEPGPGGFAIPSFVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHA4</accession>
    <name>A0A1H6DHA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">16S rRNA (Guanine1207-N2)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84827">
        <property type="protein sequence ID" value="SEG84827"/>
        <property type="gene ID" value="SAMN04489712_11775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="28"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24275" checksum="93E200DA3E71278D" modified="2017-01-18" version="1">MGEHYFAERPETASRRGTVDLVLPDLHLRLATDRGMFSPDRIDPGTRILLETVPPPPPDGDLLDLGCGYGPIALTMATRAPRARVYGVDVNIRALELGQVNAQAAGLDNVRFIRPGEIDPDVRFAALWSNPPIRIGKAALHDLLTTWLDRLSPGATAHLVVQKHLGSDSLHRWLDQHDWPTERIASRSAYRVLAVTARPPRDPAGPDDGGLPGRPHREETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIP9</accession>
    <name>A0A1H6DIP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_117148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85148">
        <property type="protein sequence ID" value="SEG85148"/>
        <property type="gene ID" value="SAMN04489712_117148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="14"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG85148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="478" mass="51168" checksum="0FAD1917AB8DF0B2" modified="2017-01-18" version="1">MKRLLIDGKLVEAERTFASLNPATGEVLGQAPEATTAQAEAAVAAARRAFDTTSWPTDVEFRIRCLDQLHRALVEHREELRELTMAEVGATRINTHGPQLDEPIEQVRYYADLLRTYPLTEEIGDAEIRGQIHRRWVEKEAAGVVAAIIPYNYPIQLALAKMAPALAAGCTVVLKGAPDTPLITLALGELIAEHTDIPPGVVNVLTSPQVAVGEVLTTHPEVDVVTFTGATATGRRIMAAASDTIKRVFLELGGKSALILLDDADLTAAAPFAGFAACSHAGQGCAINTRLLVPRHRHDEAVQYVAAVMGKVTYGDPTDPKNFMGPLISERQRDKVDGMVQRAVAAGATLVMGGEKIDPGFFYTPTLLANVDPGSEIAQEEVFGPVLAVIPFEDDDDAVRIANDSIYGLSGGVCSADEERALAVARRIRTGTMSINGGNYFTNEAPFGGYKQSGLGREKGVPGLEEFLELKTYAKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DM60</accession>
    <name>A0A1H6DM60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86362">
        <property type="protein sequence ID" value="SEG86362"/>
        <property type="gene ID" value="SAMN04489712_11962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="15"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="170" mass="18248" checksum="0CE06157BBD7855B" modified="2017-01-18" version="1">MTEPLFESTQFRRVCGQFPTGVTAVTAMTADGRLAALTVNSFTSVSLDPAKVLFCLANSSSSFQTLTEAKRIAIHILNQDQEDVARRFATSGLTGAERLDGVRWIPGPDGIPLLPGTPAILAGHRDEIITSGDHAIILVSVDHVHLKPTDTPALSFYQGRFTTPVVTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNH8</accession>
    <name>A0A1H6DNH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86313">
        <property type="protein sequence ID" value="SEG86313"/>
        <property type="gene ID" value="SAMN04489712_11950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="419"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="507" mass="55737" checksum="3F14969328667FC8" modified="2017-01-18" version="1">MATSNFSETLRVQALRRAGREALVGDGRRWTYAELDADVDRHAAALLSGGVTATDMVGVLGRNTATYVIELLALSRIGAVAVPLNWRLHANEQAYIIDQAGITCLLYDDDFRADAAHLKENTRLRVVIANGQDPLPGVERLDTLLSAQSPDVRVADAEKGPDDVHRLLYTSGTTARPKGVIHTYGNLVANHRAQILELELTQDDRILISAPLFHVSGLEAPGLATFVAGGTMVLTPTFQAADIARIAAEERITGMVLAAQILFGIMELDPLPRLDDLRYLLFAGVAPSVRRKVKDLFPHVRTVDTFGMTELCNGVCYMDAAHEESKLGALGAPFPGVHIRIVDEDFQEVPPGVEGEIIVRGDKISPGYWNDDEANRATRRDGWFLTGDVGRMDEDGYLWFVDRRADLIKSGGENVAGAEIERVIARHPQVAEVAVIGVPDEKWDEVPKAFVILREPGAVAPEEIRRHCLDDLAKYKVPKYVDIVDSLPRNDSGKVLKKRLREREEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPY0</accession>
    <name>A0A1H6DPY0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="14">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-IPM isomerase</fullName>
            <shortName evidence="14">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">leuC</name>
        <name evidence="17" type="ORF">SAMN04489712_120104</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="14"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87290">
        <property type="protein sequence ID" value="SEG87290"/>
        <property type="gene ID" value="SAMN04489712_120104"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="16">
        <location>
            <begin position="7"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SEG87290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="465" mass="49196" checksum="A278DE10B8BFA5CA" modified="2017-01-18" version="1">MGRTLADKVYDAHVVRRAEGEPDLLYIDLHLVHEVTSPQAFDGLRLAGRTVRRPDLTIATEDHNVPTQNLLAPIADPVSRTQVETLRKNAAEFGVRLHPMGDDGQGIVHVIGPQLGLTQPGMTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPQVKPKTMAITVNGELPEGVTAKDLILAVIARIGTGGGQGYIIEYRGEAIRSLSMEGRMTVCNMSIEAGARAGMIAPDETTFAYLKGRPHAPQGAEWDAAVAYWKSLRTDDDAVFDKEVVIDAATLTPFVTWGTNPGQGLPLGESVPDPASFADPVERQAAERALEYMGLTAGTPLRDIEVDTVFVGSCTNGRIEDLRAVAEVLRGRKVADGVRMLVVPGSMKVKAQAQAEGLDEVFKAAGADWREAGCSMCLAMNPDKLAAGERSASTSNRNFEGRQGPGGRTHLVSPAVAAATAVTGRLAAPADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQF6</accession>
    <name>A0A1H6DQF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86906">
        <property type="protein sequence ID" value="SEG86906"/>
        <property type="gene ID" value="SAMN04489712_12031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG86906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="284" mass="31516" checksum="B3E185E48434EAA3" modified="2017-01-18" version="1">MRRRLTPYLMILPAGLWLVVFFAVPLIMMASLSLQQGNLVDGFQQTFHWQNYTEGLSTYGDKVVRSLWYGLLGTVACIVIAYPVAYWIAFHAGDRKSTYLFLLLLPFFVSFILRTVSWKFVLADNGIVLGTLKGWGLLPEGFHVLQTSFAVIAGLAYNFLPFMVLPIYVALERIDYRVIEAAKDLYAGRVQAFVRVVLPLSLPGVFAGVIMTFVPISADYVNAAILGGPQNTMIGNVIQTEYFNNSNYPTASALSFTLMAILLVGIFLYARVLGTKDVLEAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DR15</accession>
    <name>A0A1H6DR15_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ORF">SAMN04489712_12076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87146">
        <property type="protein sequence ID" value="SEG87146"/>
        <property type="gene ID" value="SAMN04489712_12076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG87146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="7021" checksum="41E35BCB87CB7CDA" modified="2017-01-18" version="1">MASVCDVCGKGPGFGMRVSHSHRRTPRRWNPNIQRVRAVVNGTTKRINACTSCIKAGKVTRPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU07</accession>
    <name>A0A1H6DU07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88837">
        <property type="protein sequence ID" value="SEG88837"/>
        <property type="gene ID" value="SAMN04489712_12290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="39024" checksum="ABB467166F695194" modified="2017-01-18" version="1">MSIGPMNHTAPHGGRTARIGLWGASGSGKTSYLASLFVAVNQTQGRWNIVGVDKESVDFLAEKTDTLTRRRRFPLKTEGIQHLSWTVMGTTEQTVRERWRKRTETVPLHIQLDMIDAPGGYFKGAEEDEKAGEDLDIDIDFNDAEDASAGGGNTPEDLIDQLTECDGIIYLFDPLRENEHGDEFQHFQWALQNIVHRAAQNGTLDGMHLPHHLAVCITKLDAPKVFHTASKRGCLTVDPDDPYLFPRVRDDKVEDLFRDLGRLSPTRSALMVHDAIKASFHPGRVRYFATSAVGFYLGRRATRFRVADFQNVIPDPDERQKYAIRGDIHPINVLEPLLWLGQQTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DV35</accession>
    <name>A0A1H6DV35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89141">
        <property type="protein sequence ID" value="SEG89141"/>
        <property type="gene ID" value="SAMN04489712_12329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="138"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="250"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG89141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="407" mass="44668" checksum="A0138045836664E2" modified="2017-01-18" version="1">MDFGLSPRAQEYTARLRDFMDTHVYPAETVYATQRAELTAAGQQHTVPPVVEELKVEARRRGLWNLFLPDADDPAHGLTVTDYASLAEIMGRSPHLAPEATNCAAPDTGNMEVLHMFGTPEQQERWLRPLLDGEIRSAFAMTEPEVASSDATNIATRIERDGDEYVINGRKWWITGTADPRCQIMIVMGKTDPEGHPYRQQSMVLVPMDTPGVEVVRPLPVFGYSDQHGHCEITFTDVRVPVANLVGEEGGGFAIAQARLGPGRIHHCMRAVGMAERALELMCERAVSRVAFGKPLARQGVIQQQIAESRMAIEQARLLTLKTAWLIDRHGAKGARAEVAAIKVIAPRVALEVVDRAIQVHGGAGVSGDTPLAQMWAALRTLRLADGPDEVHVRSVARAELGRYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWT8</accession>
    <name>A0A1H6DWT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine protein phosphatase PrpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89810">
        <property type="protein sequence ID" value="SEG89810"/>
        <property type="gene ID" value="SAMN04489712_12474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="104"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG89810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="368" mass="37784" checksum="BFF7C7208021F9FC" modified="2017-01-18" version="1">MEPSAAPRCPACAEPVHADDDFCEACGRPLRGAAPPSFQPVPVPPAPALRTPPPGPPPAPQSRPAAAPCAECGGTDISADGYCEQCGLRQPSGREHVEIETAAAVGVSDRGLRHSRNEDAMAVASACGKVVAVVCDGVSSAPRPEDASRVAAETGAAMLTAQLTAGADPREATRAALARAGKAVAALADSPHDAPACTYVSAVVDDTAVTVGWTGDSRAYWISGGDGARPSAALTVDDSWAARMVELGLMTPAEAHADRRAHTVTAWLGADAGAIRPRAETFEPGGSGAVLLCSDGLWNYLPEAAELAEAVHTARARDPRRPPLEIVRTLVRTALEAGGHDNITVVLIPFPPSRAEAADRVPHGEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWX2</accession>
    <name>A0A1H6DWX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89842">
        <property type="protein sequence ID" value="SEG89842"/>
        <property type="gene ID" value="SAMN04489712_12486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG89842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="488" mass="53905" checksum="74163B8A45804CE2" modified="2017-01-18" version="1">MMNSPQNESQVVASILRALENLGWSEAREIAPAGWQPDLVAVNGGGSLLCMEIRLGRQPLHSQIVRLLEQARADLASSWPGRSIVALLTTNPVSARLRSVSTSSGIVLIEAESTHDYRQLPSELAQALETLENRPSGEVGLTNKATLAIQAERWNDARDLYVQILEGQRNMLGDDHPVVLETKHRLAFLLTQTGDPDGAVRLYEQLAEQRERALGSGHPKTIESHSNLAYSYETVGDLGRAIPLYGRVLSERVQELGEDHPDTLTARNNLAYAYQEVGDFAKSIPLLQTTLADRERILGNEHPDTLVSRNNLAYAYYAIGDLERAVPLLEQVAVDRMRILGPDHPDTLTSRNNLASAYEAIGDLSRAASLYEGTLRDRIRILGSDHPATLTSRNNLASAYEAIGDLSRAISLYEDVLTTSVRVLGEHHPDSLTVRNNLAYAYQAAGDVDRAIFLLEDALEKSLRVFGDKHRLTATIRSNLNHLRHDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXX2</accession>
    <name>A0A1H6DXX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89435">
        <property type="protein sequence ID" value="SEG89435"/>
        <property type="gene ID" value="SAMN04489712_12392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="27550" checksum="8B8A6D8BE38CB57D" modified="2017-01-18" version="1">MAKLNQIIAVEKGVKSKSFQELTQAHQALQKLPPLSGISRTYQPKDEEGEQLPPESTRVQVKAEDTLRQVAATLTRLFDVTATKDWANCTARADVTVDGRALLREVPVSYLLFLEKQLKDLHDFVRKLPVLDAAESWTYDASTDVWRTEPVRTVKTKKVPRNHVKAEATDKHPAQVEVYYEDVPVGYWTTVKFSGALPAKRVNELLDRVEKLQDAVKYAREEANSAEVTDRHVGQAVFDYLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ89</accession>
    <name>A0A1H6DZ89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90133">
        <property type="protein sequence ID" value="SEG90133"/>
        <property type="gene ID" value="SAMN04489712_12548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG90133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="23150" checksum="69AEC5A7E6658ACD" modified="2017-01-18" version="1">MPRPSVEAERREQILRAACEVISEKGYKALRVTDVARHAKLSTGSVHYYFETKRDLVHAAFEWNFSRSLERRKSILDRHPNARDRLHAFVDSYLPRDDETAAAWRVWAETWVEALHDPDLRKLNERIYGEWRGIIAEIIRLGQAEGLITPGDPVLLANVLVSMIDGLAIQALVGSKHMTIGRMRSVCDHLLETMSAEPVQAAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZB1</accession>
    <name>A0A1H6DZB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90086">
        <property type="protein sequence ID" value="SEG90086"/>
        <property type="gene ID" value="SAMN04489712_12534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG90086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24410" checksum="1AFAEE32C3B016D3" modified="2017-01-18" version="1">MAPLRVLVCDALPLVRDGLHTILDAQQDVEVVDATESGIHAIMLARTRRPDVIVTGLQLVGVSGLELIRRLRAEGLDPEPRVVVLAMSHSDETVTEVLRAGANGLLTEDATREEVVAAIRAAARGQTMLSPTVTERLVDWFRRREVYPHELLRPAVAALTPRERQVLLLVAQGRSTEEVAGELYIGVSTVRTHLHRLRAKLDLKDRAQLVSFAYRSGLMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZL8</accession>
    <name>A0A1H6DZL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Parallel beta-helix repeat (Two copies)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90549">
        <property type="protein sequence ID" value="SEG90549"/>
        <property type="gene ID" value="SAMN04489712_12669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296348" evidence="2">
        <location>
            <begin position="30"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="695" mass="75280" checksum="BF54EBEB9354CB55" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E353</accession>
    <name>A0A1H6E353_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91977">
        <property type="protein sequence ID" value="SEG91977"/>
        <property type="gene ID" value="SAMN04489712_13153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="27825" checksum="00F14307EE39A623" modified="2017-01-18" version="1">MNTTQSIQPSAQVVSGTPLAGRVAVVTGASSGIGEATAVRFAELGAKVALVARRGDRLDQVEDRIRAGGGTALALPTDVTDRAAVLAVADRIADELGQVDLVFANAGVQLISGITDLAAADWDAQIDLNIKGVMNTIQAFVPSLESAAAAGRSADLITTSSIAAVRILEGFQVYSATKAYVTQLAKLLRTELGRKKIRVATIEPGMVDTELPDHVTDPAASKLMADLIAQIDVLSSEDVAETVAFMSAVPKHVNLTEITILPTEQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6S0</accession>
    <name>A0A1H6E6S0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93392">
        <property type="protein sequence ID" value="SEG93392"/>
        <property type="gene ID" value="SAMN04489712_13841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="124" mass="13502" checksum="5C9FF6E5A046F183" modified="2017-01-18" version="1">MPDYDAYDKAMRPEDITRLFVERSNAGDAAGVAALYEEDAVLAYPPGSQTVGREAIRALWEKVLAGRPRFEPEEPLPTLVSGDIALTSTPPGDGAGARAQVVRRQPDGSWLRLLDQPEFVPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E963</accession>
    <name>A0A1H6E963_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">SAMN04489712_13839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93385">
        <property type="protein sequence ID" value="SEG93385"/>
        <property type="gene ID" value="SAMN04489712_13839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="79"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG93385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="199" mass="21989" checksum="8D3A8E91CC7618D4" modified="2017-01-18" version="1">MYEGVVQNLIDELGRLPGVGPKSAQRIAFHLLAADPADVERLTKALREVKDKVRFCRTCGNVAEEDECRICRDPRRDPAVICVVEESKDVVAIEKTREFRGRYHVLGGAISPIEGVGPEDLRIRELMQRLADGTVTELILATDPNLEGEATATYLARLVKPMHLKVTRLASGLPVGGDLEYADEVTLGRAFEGRRLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB03</accession>
    <name>A0A1H6EB03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">T/G mismatch-specific endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_14311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Vsr family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94106">
        <property type="protein sequence ID" value="SEG94106"/>
        <property type="gene ID" value="SAMN04489712_14311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00221">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004603">
        <property type="entry name" value="DNA_mismatch_endonuc_vsr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03852">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00632">
        <property type="entry name" value="vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG94106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="134" mass="15433" checksum="105002C60CE53B27" modified="2017-01-18" version="1">MQSNKSRDTKPEMALRRAAHALGLRYRVSARPLAAIRRTADMVFTKVKVAVFLDGCFWHGCPEHHTKSATNAEYWAEKVQRNRDRDAETDRLLAEAGWLVIRVWEHEDPIEAAEHIAEQVHARRNRPQPTQAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S2J8</accession>
    <name>A0A1H5S2J8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipB</name>
        <name evidence="11" type="ORF">SAMN04489712_10155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44832">
        <property type="protein sequence ID" value="SEF44832"/>
        <property type="gene ID" value="SAMN04489712_10155"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="51"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 9">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF44832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="26606" checksum="770805381D4E2E99" modified="2017-01-18" version="1">MTDVLEAGGTQAAATRTGDLVIVHVGFGEHAIPYETAWELQRRTQERRIAGEIPDTALLLEHQPVYTAGKRTTPLDRPLTDPGAPVIDVDRGGNITWHGPGQLTGYPIVRLPDPVDVISYVRRLETMMMKVCAELGLETVTVEGRRGLWVPGRPDRKIGSIGVRVSRGVTMHGFMLNCDCDMSWFDRIVPCGIRDVGSTSLSEELGRRVPVQEILPLVERHLAEVLGVRETFHRTLAQLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SFN2</accession>
    <name>A0A1H5SFN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49409">
        <property type="protein sequence ID" value="SEF49409"/>
        <property type="gene ID" value="SAMN04489712_101190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="457" mass="46877" checksum="60972FB57CE29371" modified="2017-01-18" version="1">MGRGAGFLDEAWACLGGRPGTVARTGPDVTLPARLPVTELAGATVAAASLAAAELAEARGAGRPAVRVDSRAVAVAFAGERHLRVDGKAEPSFAPLSRFWRAADGWVRTHGNYPHHRDRLLRALGLEVSLTDPVPAVEKTIAAASAAEVEASVQAAGGLAVAVRTPAAWAAHPQGAHVAALPLLRLTRAGDAPARPLGPVPSGPLLPMAGLRVLDLTRVIAGPVGTRTLALLGADVLRVDSPRLPEIPAQHLETGAGKRSALLDLDEAAGRTRLSELLGAADVVVTGYRPGALDRYGLSPAALAAERPGLIVACLSAWGSIGPWADRRGFDSLVQAASGIAVTEAGGDPAPGALPVQALDHGTGYLLAAVVMRAVTRRAAEGGGWHAELSLAQTAAWLLRRPAAPDAAAAGFDPSPYLAESGGIRRALPPIDLGGGPRTWAHPVTPWGSDTPSWRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SSI6</accession>
    <name>A0A1H5SSI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53566">
        <property type="protein sequence ID" value="SEF53566"/>
        <property type="gene ID" value="SAMN04489712_101347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF53566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="311" mass="32007" checksum="9E4A834C0F72C065" modified="2017-01-18" version="1">MTPVSRRVPDLAALELLLAVVRLGSVGRAAAELEITQPAASARIRSMERRLGVALLERSPRGSRPTEAGALVAGWAAQVVEAAQALEAGARALRERRDGRLRVVASLTVAEYLMPGWLLALHEVRPGTAVTLRTANSAAVAERVLAGEADLGFVEGIGAPAGLGGTVVATDSLVVVVAPRHPWARRRGAVTAGELAGTPLVLREQGSGTREVLDRALAAFGGAAAPLLELASTTALKAAAVSGAGPVVVSELAVADEVAGGRLVAVPVADLDLRRPLRAVWPAGRRPSGPARDLLSLARPSPRPRRGGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T1V5</accession>
    <name>A0A1H5T1V5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56148">
        <property type="protein sequence ID" value="SEF56148"/>
        <property type="gene ID" value="SAMN04489712_101430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284532" description="DUF1524 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="104"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF56148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="22644" checksum="10AB027C794C62DB" modified="2017-01-18" version="1">MRRPVLVALTTILTALTAPPATAAPPPPPEAVTALEHLVALRTEAEGSGAGYSRELFPHWITISGTCNTRETVLKRDGVNVVTNKGCAAVSGSWYSPYDGATWYAASDIDIDHMVPLYEAWQSGADTWTTERRRRFANDLESSQLWAVTDNVNQQKSDKDPATWKPPLESFHCTYARSWIDVKWRYDLSADIAEKAALTTMLATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T1Y4</accession>
    <name>A0A1H5T1Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56178">
        <property type="protein sequence ID" value="SEF56178"/>
        <property type="gene ID" value="SAMN04489712_101431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="274"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF56178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="40261" checksum="497665381FCCF528" modified="2017-01-18" version="1">MNSAMNDVYVVDAVRTPIGKYSGALAGVRPDDLAAGVLRALVDRSPALDPARIDDVIFGNANGAGEDNRNVARMAVLLAGLPVSVPGATVNRLCGSGLEAVIQASRAVAVGDASIVVAGGVESMSRAPWVLPKPERAFPAGNAELVSTTLGWRLVNPAMPAEWTVALGEGAELIADKYGISREEQDAFALGSHRKADRAWHDGVYDAQVVPVAGAELSRDETIRPGTSLEALAKLKPAFRPDGTVTAGNASPLNDGAAALLLADEAGLAALGRRPLARIRASAATALEPQMFGLGPVEAITRALDRAGRTFADLTTVEINEAFAAQTLGCLAALPELDPALVNPDGGAIALGHPLGASGARLAGAVAHRLAASGGGLGVASLCIGVGQGLALVLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T3B9</accession>
    <name>A0A1H5T3B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crotonobetainyl-CoA:carnitine CoA-transferase CaiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57392">
        <property type="protein sequence ID" value="SEF57392"/>
        <property type="gene ID" value="SAMN04489712_101470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF57392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="417" mass="44972" checksum="097CBD474268CCE5" modified="2017-01-18" version="1">MTQEAGPLGARLLSGLRVVECSMLGPGAVSTPLADLGADVIKVEPPSGDYIRSMSWPLVRGSSLLHLHISRGKRSIVLDLRTDAGRETFLALVAEADVVVEAMRPGGLDRRGLGYERLREVNPRIVMFTISGYGMTGPYRDLPSHGIAYDAWAGTVAPVPGPEGMPSIPDHTSIGITAGPLFGTAAILAAVLRARETGEGCHLEVAQSDAAAAFDWLRSEGHRAYERPADEVTGNPSDGYERRPPGTAGMAEGVRYQFYESSDGHVLFMASERKFWENFCTAVDRKDLFEAHPGEKLADHARGNRELRRELAAIFRTRTTAEWIELGLAHDVPIGPVNTPATIAADPQFTARMPWQSADRLVADQLPFPVRVVGEDPPAASRPAPAPGEHGEQILHDVLGYDTGRIAHLRAEGAFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TAX4</accession>
    <name>A0A1H5TAX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59939">
        <property type="protein sequence ID" value="SEF59939"/>
        <property type="gene ID" value="SAMN04489712_101549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF59939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="101" mass="11325" checksum="57FAD7D0C00A5B51" modified="2017-01-18" version="1">MTANRTDVPRYLESERLDEITRMLTELASEVWILRDRTLVLEHLLRERGCLDEGAVEALRPTGELLARLGEERGAFVSRVFGAVLDTDTRVAAATREAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TS48</accession>
    <name>A0A1H5TS48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65614">
        <property type="protein sequence ID" value="SEF65614"/>
        <property type="gene ID" value="SAMN04489712_101726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013630">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038576">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013691">
        <property type="entry name" value="MeTrfase_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08421">
        <property type="entry name" value="Methyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08484">
        <property type="entry name" value="Methyltransf_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_13" evidence="1">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_14" evidence="2">
        <location>
            <begin position="255"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF65614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="422" mass="46131" checksum="7D4E814514F89300" modified="2017-01-18" version="1">MGASGGGVRKVVDCRVCGGTDWQEVVSFGPVPLANGFLDPTDSYDGEPYYPLGVISCRSCRLLSVTHIVDPEILYRDYPYVTSDSDTITRHMRYVADTCRERFGLSPGSFVVEVGSNTGSQLMPFQDAGMRVLGVDPARNLARVAAERGVETLPDFFSAETASAIARGHGRARLILARHVFAHIDHVAGVVQGVRGLLSEEGVFAVEVPYLLDLFGQNAFDTIYHEHLSYFSVGTLVSLFERHGMRLFDVERLAVHGGSILVFVQRDDGPWPVRPAVGELLELERRAELDGDAVYRDFALNVDRVRDELPALVRRLAAEGKRIAGYGASAKGNTILNVCGFRPGELEFCSDTTSLKQGKVLPGTHVPVCSPEYAKAHAPDYYLLLAWNYSDEILRKEAGFLSGGGRFIRPIPKPVVVSADAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UU24</accession>
    <name>A0A1H5UU24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78460">
        <property type="protein sequence ID" value="SEF78460"/>
        <property type="gene ID" value="SAMN04489712_10222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF78460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="14868" checksum="C3A9F8CE2D3324A8" modified="2017-01-18" version="1">MAGAHGGAGTSTIARLMYPAWDMGSLEHLLGPGHPPLRDRRRPLAVVTRNTVAAARHATNAVTALHQAATPIAALVIVADGAGSEPRDATARFSLLQGRVGGIVRMPFISDLRLVDDATTIDLPKRARDALGAIRALAYGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UVK3</accession>
    <name>A0A1H5UVK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78237">
        <property type="protein sequence ID" value="SEF78237"/>
        <property type="gene ID" value="SAMN04489712_10212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF78237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="504" mass="53102" checksum="CA43A7B157B3A1B4" modified="2017-01-18" version="1">MATFGELLSAADGHLAQAASTLNRPDIDVQAQHPGTIIELARLTAVLARYGDNIADGFGLQPNGDEAVREAARRFSRNIHQARNVLGTPGRADPSGPDLAWTLRAASDTLGCGLDLLNSHFTRTSGGGLHSPSANAMTITAGDVLGSLLHKLGRYAEAAGHLTRRSTPEAAKAADPLIRAADSGPTPASGRASPVEAVTLRRAMERIPPVPGESTARLLEGISTSAQRLRNMDPQGSIATWRYLATAAAIACQIGSRITSVMAYRFRETGEEELAAPLLEAARRTRLIGMRWQTLAQNWRSLTGMPSNPATVPAAVDASDLLIRLGRLIYADPAWTPGPRGTTQVVPPEQLAPDAGHAARIGLAVLNSIEACNVMAAAHNAAVNDVARITLTRRGLAAPDGRRRPPAVARQFLTRYEGVLQHGKEAVIHLGNTVLELTPKGSETAAEAALIIRRANAPNSHESPAALAAQSFPSLTTQALHTLAQQAASPSSPVARPKSNSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V8C0</accession>
    <name>A0A1H5V8C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83434">
        <property type="protein sequence ID" value="SEF83434"/>
        <property type="gene ID" value="SAMN04489712_102207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="113"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF83434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="30387" checksum="07793FF5E1EEC511" modified="2017-01-18" version="1">MLPLPATPPERSISSLRDDPGDGDDLGLYWTFYWAVAAAQLQRWLPEQPSRVLDISGGRTLTAARAAAAGHTVVEVLAAPPAAEAPHPDPRAPSGPPDGREAARSARGRAQGTAGRRHRVVADVASLGFLADGSVDAVIAEDRVLSRHLVTETIIGELARVLRPGGRMLLSVDSLMLGMAILAEQNFWAHLSDVPRAEVLLVPWPDGTITRCFWSDQLRELLTEAGFEVEWIRPRTVLSPSTVEHVLTADAHALGRLVRTELTALVTDESVGIHLLASATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VIP1</accession>
    <name>A0A1H5VIP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86397">
        <property type="protein sequence ID" value="SEF86397"/>
        <property type="gene ID" value="SAMN04489712_102315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF86397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="27401" checksum="D991CAA65BAF5D24" modified="2017-01-18" version="1">MSVPPETGRVLVIIPTYNERENIERIVGRVLASAPADVLVVDDASPDGTGLLADAMAARDRRVQVLHRAGKDGLGSAYLAGFGRGIQQGYDVLVEMDADGSHRPEELPRLLTALTGADLVIGSRWVRGGRVPDWPLRRRLLSRGGNLYTRLLLGLPVQDATGGYRAYRATALEKIGLDDVQSQGYCFQVDLTLRTVRAGLQVTEVPIEFADRVRGESKMSRAIVLEALGRVTRWGISHRLGRLGWRGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VIR9</accession>
    <name>A0A1H5VIR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">SAMN04489712_102325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86711">
        <property type="protein sequence ID" value="SEF86711"/>
        <property type="gene ID" value="SAMN04489712_102325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="33"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF86711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="571" mass="61918" checksum="07A2A802FDDD1066" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VJU9</accession>
    <name>A0A1H5VJU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-Methyltransferase involved in polyketide biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87625">
        <property type="protein sequence ID" value="SEF87625"/>
        <property type="gene ID" value="SAMN04489712_102350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF87625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="29796" checksum="6ABF568B002926D7" modified="2017-01-18" version="1">MSSPSGPGESSLDRPHSARIWNYWLGGRDYYPADKEAGDAMARIIPGVVDSARADRAFLGRCVRHLVVERGVRQFLDIGAGLPTAGNTHEIAQRLAPESRVVYMDNDPLVLAHAQSLLIGTPQGAARYVEADLRHPDGVLERAAETLDLTRPVALMLLGVLNHITDDAEAGRLVRHLVEAVPRGSYLAIAHPTDEVRGDVVHEAMWRYMKRGGTPTVARDRTRLARFFEGLELLEPGVVPCAHWRPDPSAPSASPEFATVCAVARKPARTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VVE7</accession>
    <name>A0A1H5VVE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ORF">SAMN04489712_102479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91269">
        <property type="protein sequence ID" value="SEF91269"/>
        <property type="gene ID" value="SAMN04489712_102479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF91269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="25438" checksum="DAB968DC54659917" modified="2017-01-18" version="1">MRLVIAHCSVDYVGRLTAHLPPAPRLIMVKADGSVSVHADDRAYKPLNWMNPPCSLREERFAEPQEDGAVARWTVTHGKSGERLILTVTEFLHDSSHELGIDPGLRKDGVEAHLQELLAEHITTLGDGWTLVRREYPTAIGPVDILCRDADNATVAVEIKRRGEIDGVEQLTRYLELLNRDPLLAPVRGIFAAQEIKPQARVLAADRGIDCVTLDYDALRGIEHEGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VX00</accession>
    <name>A0A1H5VX00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpE</name>
        <name evidence="15" type="ORF">SAMN04489712_102500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91812">
        <property type="protein sequence ID" value="SEF91812"/>
        <property type="gene ID" value="SAMN04489712_102500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEF91812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="73" mass="7497" checksum="5EE4597B6BEF1393" modified="2017-01-18" version="1">MFLAEVSGNVGSIAYGLAAIGPGIGVGIIFGQGVQAIARQPELTNVIRQNMLLGFALTEALALIGFVVPFVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W604</accession>
    <name>A0A1H5W604_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94850">
        <property type="protein sequence ID" value="SEF94850"/>
        <property type="gene ID" value="SAMN04489712_102599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF94850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="153" mass="16272" checksum="7AB9B77E436BB4FB" modified="2017-01-18" version="1">MTDIVPMWHDKRGAGDPVVLLHGGLTDGRCFTGNLDGLAGTFTIYLPDRRGHGRTPDVPGPITIDLMARDTVAFLEGVVGGPARLVGYSAGGTVALYRALPNAELAVLPNPSHLLLMEHAETARTMVRTFLTTDAAPTYMPIARARQGAPNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WCU0</accession>
    <name>A0A1H5WCU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">SAMN04489712_102669</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97213">
        <property type="protein sequence ID" value="SEF97213"/>
        <property type="gene ID" value="SAMN04489712_102669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEF97213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9894" checksum="D893672EFA014FBA" modified="2017-01-18" version="1">MSEVVIPLAHGTFGEELGWQERALCAQTDPEAFFPEKGGSTREAKKVCRACEVRAECLEYALQHDERFGIWGGLSERERRKLKRQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WXP6</accession>
    <name>A0A1H5WXP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04261">
        <property type="protein sequence ID" value="SEG04261"/>
        <property type="gene ID" value="SAMN04489712_1036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG04261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="24698" checksum="CC2B751F0A674971" modified="2017-01-18" version="1">MTPVVELREVTRTYPGGVTALDRVSLAVRPGELLAIVGPSGSGKSTMLHLLGTLDRPSSGTVLFEGQDVSKLSDRRLSMLRGGRIGFVFQQFHLAAGVPALDNVADGLLYAGVPLRERRRRARAALERVGLGHRLGHRPHQLSGGERQRTAIARAVVGEPSLLLADEPTGALDSVSGAGVLELLRELADAGTTVAVITHDRDIAASLPRRIELRDGRVVRDSAVEPEPAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X260</accession>
    <name>A0A1H5X260_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Streptogramin lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05623">
        <property type="protein sequence ID" value="SEG05623"/>
        <property type="gene ID" value="SAMN04489712_10351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="518"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG05623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="701" mass="72818" checksum="ABB12A29D3228B14" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X663</accession>
    <name>A0A1H5X663_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemerythrin HHE cation binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07244">
        <property type="protein sequence ID" value="SEG07244"/>
        <property type="gene ID" value="SAMN04489712_103106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG07244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="187" mass="21479" checksum="2A4E09542B32EBF3" modified="2017-01-18" version="1">MQDGQRDVIAVLTHDHRELEELFDRFTALPVTDTRTRREVTDQVIIELVRHAVAEEQYLYPAVRRHLPDGDRIADKEIADHAAAERTMKELERIDTGDHRFDDVFGRLEREVREHIAEEEDLLFPRLRSVCDGETLVDLGAKVERAKKTAPTRPHPSTPDTPPLNRLLDPGTGLVDRARDLVARRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XI36</accession>
    <name>A0A1H5XI36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11080">
        <property type="protein sequence ID" value="SEG11080"/>
        <property type="gene ID" value="SAMN04489712_103251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG11080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="29019" checksum="F2FF1FB7604F73E0" modified="2017-01-18" version="1">MPGRRERHTEESLARLRDQLHAEAERHRPDTARIWARVEAAMAEQQTTPAAGDAAPVPPPRRRGGLWVVAAGLSTATVVGVTSVVVLTLSGRDDSPAVSLGRHSTGNPSTPGLPPPPDDRRTTGQDAAPGVRPSAKPGPSRPAGGQGGGNTLVSATGSPDRGGSAYWARNNLTLTVRRPLGALDVTIRIARGRWTFPAGSWTSFPGSDLRSETQVTREAIVQRYRLLPGRKVAPGTYLIGVQYRPGGRHDPARDTFTVTATGAGGGPPVILRGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XRX8</accession>
    <name>A0A1H5XRX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14016">
        <property type="protein sequence ID" value="SEG14016"/>
        <property type="gene ID" value="SAMN04489712_103363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG14016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="72" mass="7669" checksum="7C6DC2E244658DAA" modified="2017-01-18" version="1">MQAAVGDRLHVHGNTVGQPDHSGEIIEVRGADGQPPYMVQFDDGHTALVFPGPDAVVEAGKAKARRRVPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XXZ6</accession>
    <name>A0A1H5XXZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative hydro-lyase SAMN04489712_103462</fullName>
            <ecNumber evidence="3">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16538">
        <property type="protein sequence ID" value="SEG16538"/>
        <property type="gene ID" value="SAMN04489712_103462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01830">
        <property type="entry name" value="Hydro_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016938">
        <property type="entry name" value="UPF0317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="DUF1445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029755">
        <property type="entry name" value="UCP029755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="SSF160920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG16538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="29740" checksum="5324022C5315DA0E" modified="2017-01-18" version="1">MDRTPRPKAWTTQAGNHPGMSLPDQPAVLTPTQARALFRTGATTPTTSGWCRGYTQANLLAVPRTLAFDALLFALRNPGACPLLEVTDPGDPHPRNLAPTADLRTDLPAYRIYEHGTLVAEVGDATAYWRDDLVALLIGCSFSFEAALAAAGVPVRHVEQGRNVSMYVTDRPCVPAGRLSGPLVVSMRPVPEPLVDTAIEVSTRYPAHHGPPIHVGNPAALGIADLARPDFGDPVEAEPGDVPVFWACGVTPQAVCMASGPEFVITHSPGRMFITDRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XYJ8</accession>
    <name>A0A1H5XYJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16517">
        <property type="protein sequence ID" value="SEG16517"/>
        <property type="gene ID" value="SAMN04489712_103461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG16517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="14013" checksum="0B3DD06DCB779057" modified="2017-01-18" version="1">MSVRDGFYAGWRGLEYEASPDDEMVRLYTGVPAEGFEEVAPGRHVRVVAADEIEHLSYVVTMCTWRDEPFQVLGEHETWLRVEYAGQDAEVAERLGLDTFDLGVYQAWAPRAEVRGLREERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y2C5</accession>
    <name>A0A1H5Y2C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17706">
        <property type="protein sequence ID" value="SEG17706"/>
        <property type="gene ID" value="SAMN04489712_103506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01782">
        <property type="entry name" value="MCEVIRFACTOR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG17706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="36279" checksum="E25B76CB1B4EF1E6" modified="2017-01-18" version="1">MKPIQERNPVPIAVIGLVLVLVLGLLAYRADDLPVIGGGTTYTAHFTEAAGLNTSSEVRVAGVKVGKVTGVRLDRGRVKVSFRVKDVWIGNASTVAISIQTLLGDKYLAVAPLGSAAQNPRQTIPTNRTRAPYDVTQAFGDLGRTFGQLDTAKVAQSLQVISATFRDTPPDVRKALDGMTALSRTISSRDDRLARLLAGSDRLTGTLASQNTEYEALLKDGNLLLEELRLRREAIHRLLVASRELSRHLVGLVRDNEAQLAPTLTALDRVAKVLQDNQRNLDKALAIAGPYYRLVGNTLGNGRWTDAYLCGLVPKEYLKPGTPPANGCMPPKVGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YR67</accession>
    <name>A0A1H5YR67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25836">
        <property type="protein sequence ID" value="SEG25836"/>
        <property type="gene ID" value="SAMN04489712_104109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG25836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="341" mass="37411" checksum="41483FD2F8B43700" modified="2017-01-18" version="1">MPRNVLAFVPQHTTTKSRIMALVDKGSGLEIDAVATVDWPHEAVAICNILNVDDGREALSGLWVSLPASVKANLEKVQEERVGEADGRYPLASLFITELDIPELPDPDAFIDWAKLFPVAQCPPGGCDWCEGCPGHSKSRGDGEVVNQCAPGGSCSCQSEDLEGDLDDCMCGLWDVGPRWAAAIYKSLAEISEVIVSHAEDLMWGVEGPAVGFPRSLVAQAPQFYLRLAQTCMDLCKELESGRVPVPHTIAELIMLDEAARSYLEGRTGGDGLDRDAMEKEMGHLPEAHGDFEMDALWMFQFTDSDWIDIVEADTVFDPHTMDRVFDTLPEAKDWPRPQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YTH6</accession>
    <name>A0A1H5YTH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27421">
        <property type="protein sequence ID" value="SEG27421"/>
        <property type="gene ID" value="SAMN04489712_104177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290871" description="DUF4142 domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="4">
        <location>
            <begin position="33"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG27421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="26102" checksum="4A72D3071882F6F9" modified="2017-01-18" version="1">MSILRAVLTAGAVIAFSAGAMSPAAARPGVPAQDRGFLIAAHQGNLTEIMAGKAAQQKAQASVVRAIGQRFVTDHTRLDTAVQDAARKLGVSLPMRPTQKQQAEYDRVNALSGSAFDRAWLEFMIREHRTAIAAGEQELRAGVTPEAKQVATSSAPVIQGHLQELLQAQKTVGTPQAQRATGTPQAQRATGTPQAVQAGAGGRAETTGQGETAENRRSPALGYGLLAAGLPVTVGGFLLWRRRALRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z832</accession>
    <name>A0A1H5Z832_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplJ</name>
        <name evidence="9" type="ORF">SAMN04489712_104383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31885">
        <property type="protein sequence ID" value="SEG31885"/>
        <property type="gene ID" value="SAMN04489712_104383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG31885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="188" mass="19427" checksum="27F7204BFFEBA88A" modified="2017-01-18" version="1">MAKADKAAAIAELTEEFTSSNGALLTEYRGLTVAQLGELRRNLGENAKFAVVKNTLTKRAADAAGIDEQFSQLLAGPSAIAFVKGDVVETAKGLRDFAKANPLLVIKGGVVEGKAMDAADVTKLADLESREVLLAKLAGAMKASMANAAATFNALPTQLALLADALRAKREESGEAAAPAADETPAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZA34</accession>
    <name>A0A1H5ZA34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="13" type="ORF">SAMN04489712_104412</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32497">
        <property type="protein sequence ID" value="SEG32497"/>
        <property type="gene ID" value="SAMN04489712_104412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG32497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="30935" checksum="EA552BFD5273520C" modified="2017-01-18" version="1">MGQKINPHGFRLGITTDFKSRWYADKLYKDYVKEDVAIRRMLQKGMERAGISKVEIERTRDRVRVDIHTARPGIVIGRRGAEADRIRGDLEKLTGKQVQLNILEVKNPEIDAQLVAQGVAEQLSSRVAFRRAMRKAIQSAMKSGAKGIKVQCGGRLGGAEMSRSEFYREGQVPLHTLRADIDYGFYEARTTFGRIGVKVWIYKGEAPTSRAEREARAAQQRSGPGGGGGERRGRGGDRRGGRGGERRGGRGGRGGDRQQQSSEQQAQPTAESAAPAPSGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZA41</accession>
    <name>A0A1H5ZA41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplM</name>
        <name evidence="8" type="ORF">SAMN04489712_104443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33162">
        <property type="protein sequence ID" value="SEG33162"/>
        <property type="gene ID" value="SAMN04489712_104443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG33162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="16471" checksum="4428E38562DA62DC" modified="2017-01-18" version="1">MRTYTPKPADVQRQWYVIDATDVVLGRLASQVATLLRGKHKPIYAPHMDTGDFVVIINADKVALSGNKLETKRAYRHSGYPGGLRSIAYKDLLAKHPERAVEKAIKGMLPKNTLGRQMFKKVKVYAGPNHPHQAQQPVPFEISQISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZBX5</accession>
    <name>A0A1H5ZBX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33574">
        <property type="protein sequence ID" value="SEG33574"/>
        <property type="gene ID" value="SAMN04489712_104461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG33574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="32915" checksum="AD935DB1FCC1BE40" modified="2017-01-18" version="1">MATSRTPTVRQRRLGAELRRLREERSLTGDGVAELLGWSPSKVSRIENARIGARVSDIRLLLELYEVDGSHLREVLALAEEAGQRGWWAQYSDLPAEYAAFIALEDEADAALQCESQVIPGLLQTERYARHVIRGWNTIATITPQAIERRVEVRMRRQELLTRPNPLRLSVVLDEAVLLRRVGDHATMHEQLNRLLELAALPSLRLRVLPLDGPHQPIVGESFILLEFSPAYDVTFPDVVHTESLTATQSQHESVTHSYRLAWESLAGQTLGNEESLERISRIARERWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZC69</accession>
    <name>A0A1H5ZC69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_104464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33640">
        <property type="protein sequence ID" value="SEG33640"/>
        <property type="gene ID" value="SAMN04489712_104464"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="235"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG33640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="372" mass="38961" checksum="8786ED0A0F2F9ADC" modified="2017-01-18" version="1">MDLDAVRANVALLRERAGGTEVMAMVKAEAYGHGLVETARAALDGGAAWLGVARVAEALRLRAAGISAPVLVAVATRGEPYEDAVAAGVDLTVGSAWLARRVTEAAERSGRAARVHLKVDTGLSRGGATMADWPATVEAALAAQASGHLEVVGLMSHFACADEPGHPSVSRQLTAFREAVEYAEKAGARPRVRHLSNSAATLTLPEARYDLVRPGIAMYGLTPIPQAGTFGLRPAMTLVAELAAVKRVPARSGVSYGHTYVTERETTLGLVPAGYGDGVPRHGSGLLEVLVGGRRRRIAGRVCMDQFVVDLVDDAVPAGDEVLLFGPGDRGEPTAQEWADALGTISYEIVTRIGTRVPRVHTGTAVERTVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZDW9</accession>
    <name>A0A1H5ZDW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34471">
        <property type="protein sequence ID" value="SEG34471"/>
        <property type="gene ID" value="SAMN04489712_104500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG34471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="33570" checksum="6C40A7641E769E94" modified="2017-01-18" version="1">MATLHQFRCFLTALEHGSFTAAAAALGYAQPSVSEQVRLLEQQLDTVLFRRAGRGLVPTEAAWALRPHAVAALKAADEAVRAVSSVRGMLTGTVRFGIFKTAHFYFGADLVADVLERHPQVRLELVGQNSAETLDQLRRGRLEAALAALPGDDEEMAVTAEMRDELVYVSADPGRVREPVTAAVLTAHPLVLPDVTWREEDTTRLLLAHIARSGGHVLRPRVEVEYLEAALEVAARGLADTVCWRGVMHRMEGRLPPGLHWAPLDPPQHERFALVHRPVAELSPATRMVIDLAAARVRQLNAALNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZU8</accession>
    <name>A0A1H5ZZU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41622">
        <property type="protein sequence ID" value="SEG41622"/>
        <property type="gene ID" value="SAMN04489712_10589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021456">
        <property type="entry name" value="DUF3107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11305">
        <property type="entry name" value="DUF3107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG41622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="76" mass="8219" checksum="13722311C565F578" modified="2017-01-18" version="1">MVQVRIGVQYVPKELVVETSLSADEVERALTDALAAEHGVLVLRDQRGGRVAIPAARVGYLEIGEEENRTVGFGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A977</accession>
    <name>A0A1H6A977_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45258">
        <property type="protein sequence ID" value="SEG45258"/>
        <property type="gene ID" value="SAMN04489712_105293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG45258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="47" mass="5219" checksum="89F296F9AF55E9D4" modified="2017-01-18" version="1">MNHSWNCDYVRYPNAEDKECHCNDLSMVDEDACLGCGSSDGCSCNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AE90</accession>
    <name>A0A1H6AE90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46484">
        <property type="protein sequence ID" value="SEG46484"/>
        <property type="gene ID" value="SAMN04489712_105366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="178" mass="19487" checksum="643D28B5EC8ABAEE" modified="2017-01-18" version="1">MTSGAPLDPIAEARRQWLRRWPEHAEHMAAITSVMRVQQILLGEVERALKPYGLTFASYEALVLLHFSRAGRLPLGKMGERLMVHPTSVTNTIDRLQAAGLVRRVADPADRRRVLAEISERGHEVAAAATEVLNAIDFGLGALAEPDAVTLSGLLRRIRRAAGDFGPEVADPWTSTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AI73</accession>
    <name>A0A1H6AI73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_105463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48221">
        <property type="protein sequence ID" value="SEG48221"/>
        <property type="gene ID" value="SAMN04489712_105463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG48221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="28278" checksum="D0A27DE2FE51B9D2" modified="2017-01-18" version="1">MTLELQDVRKRFGGVVASDGVTFRVGDGEIFGLIGPNGAGKTTAVNLITAYMRPDSGQIRFEDTEITRLKPRQLAARGVSRTFQSLRLFEGVTVADNVLIGRHRWFEGHVLLPFLGGKFEKSQRAAALKWVDFVGLGDVAAEPVDSLPYGLRRKVEIARALALEPRLLLLDEPTAGMTRTESDEVAGLIRRIREHGITVLLIDHNISLVNQVCDRVAVLDFGKVIAEDEPKAIWQNQLVRRAYLGDDEETMTGADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AUB3</accession>
    <name>A0A1H6AUB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52249">
        <property type="protein sequence ID" value="SEG52249"/>
        <property type="gene ID" value="SAMN04489712_10617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="47447" checksum="BE36012552B459D0" modified="2017-01-18" version="1">MNPSDQMTADGYLDRYEAAAERDPLGGIALLAGWLRTDWRPLFAELRAHRPVLVTPAFALVTRFTDVTDVLSRGEVFTVSGYAPRLEAALGGPVMLTRDGTPLNWREKALMQVMLPPDDVPHVRELVGRTADEALDAARPRGRIEAVGELFRHICMTVCAQYFGFPGPDAQTLSRWSRAVMTDATANLAGDPQIHAAAVRAGGEMMDHLHRLLAERRAQLAAGRPPAPQDVFGRLVRTVLPEELALDDRRVAINVAALLLGFAENASGSMVHVVQQILRRPQVHRAAAEAAHDPDPAVFDPHVWEALRLDPFLKMIPRTCAHDHVLAAGTPHETRVPAGTLVLAAVASAMFDEAVVAEPEEFRLDRPRHVGLHFGHGPHACPGVHPGAAVICETVRRLLRRPGLRLLPPPDGLVVRDRDVFPDRFPLGLDQKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AUV0</accession>
    <name>A0A1H6AUV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobB</name>
        <name evidence="6" type="ORF">SAMN04489712_10612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52182">
        <property type="protein sequence ID" value="SEG52182"/>
        <property type="gene ID" value="SAMN04489712_10612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01967">
        <property type="entry name" value="Sirtuin_ClassII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026587">
        <property type="entry name" value="Sirtuin_class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG52182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="28453" checksum="804F4D44E72C9E2B" modified="2017-01-18" version="1">MLADLVADGDVVVLSGAGLSTESGIPDYRGESGRRRRARPMTYQTFVGSAAARRRYWARSHLGWRHITGAAPNAGHRAVAELQRRGLVAGVITQNVDGLHQAAGARDVIELHGALDRVICLGCGERTPRQDLERRLRAANPGWEADAGAINPDGDAVLDDDRIDAFRIVDCVGCGGLLKPDVVFFGENVPPWRVRECYALTERAGLLLVLGSSLTVMSGYRFVRHAARHAVPVAIVNQGPTRGDAHALVTLDAPLGATLTALLTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZG7</accession>
    <name>A0A1H6AZG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA domain (Dynein-related subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53999">
        <property type="protein sequence ID" value="SEG53999"/>
        <property type="gene ID" value="SAMN04489712_106130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="67"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG53999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="37293" checksum="B5FB0029BFEBE4F2" modified="2017-01-18" version="1">MSDWHVYTGSRRPHDGITRLPDPPPWRTFDGAPVLPTPTGDSGNGHDARSYHPSEAAVRHVNAALYLRRPLLVTGPPGTGKSTLAYAVAHELKLGPVLHWPMTSRVTLRDGLYQYDPLTRLYAAGRTKDPGGSDDIGDYIRLGPLGTALLPYQRPRVLLVDEIDKSDIDLPNDLLTIFEKGSYEIVELARRADRTARVMTADRTTDRVEIRDGMVTCHAFPLVIMTSNGEREFPPAFLRRCVSVELKQPAGAEELGAIVAEHLGGVIGDDGGLPAQARRLIEHFLERRDRGMLANDQLLNAVYLCHHAVLDERPQDLLELADQVMPHLSTETTRDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B1X7</accession>
    <name>A0A1H6B1X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_106181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54809">
        <property type="protein sequence ID" value="SEG54809"/>
        <property type="gene ID" value="SAMN04489712_106181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="16"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG54809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="486" mass="50729" checksum="EDD79D18789A130F" modified="2017-01-18" version="1">MAAPPQGPAPERPQSHIVRENPARIGEIVGRVPVADAARVDRVVRDAEAGQRDWREVPAEERADVLRRAADAMDALPGIAALLARESGKPLGDCAGELRFAAAYLRWAASQAPAVYADREVDDAAGRLVLRRRPYGVVAAVTPWNAPVILTLLKVGPALAAGNTVVVKPSPLAPLAVTRVLELFPPGLVQVVHGGAETGRALVGHPAVHRVAFTGGAEAARDIGATAARVITPTVMELGGNDPVVLLDDADLSDEAMDRLVMASFATAGQVCMAAKRLYAPRSRLAEVRDAYLAAADRTLVLGDPLEEGTTVGPVISAGAAARVRALVADAVQRGGTAIGLGAVRVDVERGHFVRPTLVMGVADDAPVVAEEQFGPVVPLLPYDDEDEAVARANTGELGLGASVWSADEERAFAFARRFEAGFTFVNTHNRTGMALRAPFGGVKRSGHGREYGAEGLLEYVQTCAVHAPAAFRPGGAGMGAGAYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3G7</accession>
    <name>A0A1H6B3G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54925">
        <property type="protein sequence ID" value="SEG54925"/>
        <property type="gene ID" value="SAMN04489712_106189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG54925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="35192" checksum="5DF3487FF980BD88" modified="2017-01-18" version="1">MAEPSEWQTRIAGEWHGRPSLFDATGTWQGYEDIRRSSVFEDGATTYYMDGGLEGGGPLAGRFRLGAPFAFGVVDSDRDRIYTGPDFHGTGQPYGGFVDAHYYGPGWQVDLNTWNHVLPDGETQVYSSTLYQGWAVVGCFNGVYKRTTDYDASPETRAAIEEFLAGETRHGPVPYILPTKQRGAYSGTCELWGADQKLIGDVTVSIELEPVNLLRTRQHVTWTGAIERRYTVEARRDGFRHFYEGPDAWGNAQSFGRANYPVLHFTDVWKAKGREFMIDARPGMTAGETLTVVYELFEGNVLNCVLHGVLTWEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5Y3</accession>
    <name>A0A1H6B5Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase, alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56040">
        <property type="protein sequence ID" value="SEG56040"/>
        <property type="gene ID" value="SAMN04489712_106279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="39"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="35751" checksum="AA947A2E6D67CD62" modified="2017-01-18" version="1">MDVSVDVLGPEYEAIVLPMGKDSEGEVVATLVRRRCTDPSRRAVLYVHGFVDYFFQKHLADFYVARGFDFYALDLRKYGRSLLPHQTPNFVHSLSEYFAEIDEAVRIVREEDGHDVLLVNAHSTGGLTTALWADRVTGRGLVQGLFLNSPFFDMNIPPAVRVAGDVFSKVLRARWPKAKLPAPPAGVYARSLHCDHDGEWEFNLEWKPLYGFPVRAAWLAAIRRGQARLHAGLDIDVPVLVMASTRSARGRAAAAAVSSADVVLDVQQIARWAPRLGPHVTLVRVEGGVHDLVLSAKQARDQVFDELDRWMRGYLPSPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BIV9</accession>
    <name>A0A1H6BIV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_107146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60650">
        <property type="protein sequence ID" value="SEG60650"/>
        <property type="gene ID" value="SAMN04489712_107146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG60650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="202" mass="22049" checksum="47F718D2F3C38C2A" modified="2017-01-18" version="1">MTEARQNMPFRKPDDEGARPTDVTETLVARGAAGAVTVAWDADQAVTALYASNYRPLVRLAAMLVRDVATAEEVVQEAFIAMHGGWRRLRDPDKALSYLRQSVVNRSRSVLRHRAVVEKYAPKGLPDAPSAELGAIVELERSAVVDALAGLPTRQREALVLRYYADLSEAEIARAMGISRGAVKSHTARGMAALRNVLEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BL13</accession>
    <name>A0A1H6BL13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter substrate-binding protein, PAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_107189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61155">
        <property type="protein sequence ID" value="SEG61155"/>
        <property type="gene ID" value="SAMN04489712_107189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293848" evidence="4">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="45"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG61155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="30937" checksum="9C084512810599DA" modified="2017-01-18" version="1">MRVRQIAAVAAAAALALSVAACGSDTEKQEAESKSLVQRAKESGKLVVGIKFDQPALGLKKPDGTYEGFDVDVAKYIAKELGVQESGITFKEARSENRESFLASNQVDLVVATYSITDSRKPKVTFAGPYYVARQDTMVLADNNDITKATDLKGKKLCRAAGSNSWRRVTEPPPDGKLDIDAELVDATGYSDCTAKLESGALDAVTTDDLILAGFASQQKGKFKVINDPFTDEKYGVGVKKGDLETCEAVNKAITKMYSDGTAKTLLEKHFSGTGLKLVTTVPQFEGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BVH6</accession>
    <name>A0A1H6BVH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64632">
        <property type="protein sequence ID" value="SEG64632"/>
        <property type="gene ID" value="SAMN04489712_10841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG64632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="379" mass="40906" checksum="41400C530942C464" modified="2017-01-18" version="1">MTAANRAQAITRWSAVALMAAAVLTATASGFAQSYAGLYHWALDHGLSGWKAESFPLLVDLFIIVGELGLFLLAIDAYVIHRRNMLSWLDFCLPLTIAMAGWTASLIFNVGHVGRSEFSYQATAAVPPIVSMLGLFVLLRTLHRYVSQKEEPEEPQKPADGQPRAIAPPVTLHQVTLMPLRITGPIPQVAGARTDKALEPGTGGPRPAQAAEQSTAQTVQAEQQAPAAQAEPQPAPAPRKPKHAVPEPAPELAVVGAAARASVNGHGTLDTNALEQPTLTPEPEAPVVNPENLRNVAMTALEEHEGDLAATLAAVRAEGYHTDEDEIRRIRDNHWFPYAVYLLLAKHKGDGALVRQELTSRGIDFDPTTLEELVRSWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BX53</accession>
    <name>A0A1H6BX53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="11" type="ORF">SAMN04489712_10852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64756">
        <property type="protein sequence ID" value="SEG64756"/>
        <property type="gene ID" value="SAMN04489712_10852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="10">
        <location>
            <begin position="259"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG64756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="749" mass="81439" checksum="50BA106AEB7F7765" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXG2</accession>
    <name>A0A1H6BXG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EAL domain, c-di-GMP-specific phosphodiesterase class I (Or its enzymatically inactive variant)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65380">
        <property type="protein sequence ID" value="SEG65380"/>
        <property type="gene ID" value="SAMN04489712_108100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="373" mass="39504" checksum="BF75F9B7554B69DB" modified="2017-01-18" version="1">MDVLLPAPAAFHPVVDLGTGAVVAVTAHCEPLGSPTAFPPGDPAREDLRRALLAARAAAELGTSLPLQLSLRAETVAQGRRTLAELHQGLTGTGRRPNEIIICVSGGFAPAQRPVVTTALHDLRKAGYLVGLAGLGVAHAPLDLLVDCLPYLVRLDPDLARRSCGDPRRTALLASLVDLAHRIGTHVQAPGLATEEQVLHVREHGVRLVQGPALAPPEWRPGMGVTVPVAREEPVVRSPSADLGPRVSEFTLPAVTMDLSATADEVLNAFNAERGTSSIVLVDQYQRPRHTVDRTRFLLQLSGAYGHALHAQKPAARLADGPRLVPKTVPAIAALRAAGRDGERVYDDLVVTDEVGRCLGIVRVGDLIRSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C0G2</accession>
    <name>A0A1H6C0G2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase</fullName>
            <shortName evidence="8">L-Cys:GlcN-Ins ligase</shortName>
            <ecNumber evidence="8">6.3.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mycothiol ligase</fullName>
            <shortName evidence="8">MSH ligase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mshC</name>
        <name evidence="11" type="ORF">SAMN04489712_108193</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26176"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.13" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66441">
        <property type="protein sequence ID" value="SEG66441"/>
        <property type="gene ID" value="SAMN04489712_108193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035446">
        <property type="term" value="F:cysteine-glucosaminylinositol ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01697">
        <property type="entry name" value="MshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017812">
        <property type="entry name" value="Mycothiol_ligase_MshC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03447">
        <property type="entry name" value="mycothiol_MshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="10">
        <location>
            <begin position="43"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="8">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="8">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="8">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'ERGGDP' region" evidence="8">
        <location>
            <begin position="188"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="290"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG66441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="414" mass="45067" checksum="C24ADFE81C6BE59C" modified="2017-01-18" version="1">MRSWPAPGVPRLSEAGLSGPALPLHLHDTGTGSVRPTEPGPTARMYVCGITPYDATHLGHAATYLAFDLANRVWRDGGHTVHYVQNATDVDDPLLERAQQTGQDWRELADREIALFRDDMTALRILPPDHYIGAVEAIPLIIEMIEQLRSRGAAYEVDGDLYFPIAADPDFGRVSGLTREQMMPLFAERGGDPARRGKKDPLDALLWMVQRPGEPGWDSPFGRGRPGWHVECSAISVHYLDMAFDVEGGGSDLAFPHHEMSASHAEAATGRRPHARAYVHAGMVGLDGEKMSKSRGNLVFVSRLRGDGADPMAIRLALLGHHYRSDWEWTSEDLARATGRLARWRAAVRLPSGPSAEPVAAEVRRHLAHDLDAPAALVAIDRWAEQALSGAGEAEDAAPAQVRTIADALLGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C503</accession>
    <name>A0A1H6C503_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroloquinoline-quinone synthase</fullName>
            <ecNumber evidence="2">1.3.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Coenzyme PQQ synthesis protein C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pyrroloquinoline quinone biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pqqC</name>
        <name evidence="4" type="ORF">SAMN04489712_108287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone</text>
            <dbReference type="Rhea" id="RHEA:10692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58442"/>
            <dbReference type="ChEBI" id="CHEBI:58778"/>
            <dbReference type="EC" id="1.3.3.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PqqC family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.11" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67436">
        <property type="protein sequence ID" value="SEG67436"/>
        <property type="gene ID" value="SAMN04489712_108287"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033732">
        <property type="term" value="F:pyrroloquinoline-quinone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00654">
        <property type="entry name" value="PQQ_syn_PqqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011845">
        <property type="entry name" value="PqqC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02111">
        <property type="entry name" value="PQQ_syn_pqqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 2" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="3">
        <location>
            <begin position="20"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG67436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="234" mass="26673" checksum="94C7DD42A96E8045" modified="2017-01-18" version="1">MPGASQVLTAEEFTTALRARSARYWDRHPFHLRLHEGSLTEAEVRGWVANRWVYQKCLPQKNAFIIANCPHPEIRRMWLERIAFHDGTAEGEGGIEDWLALAESAGLTRQEVLDERHVAPGARFAVQAYLDFVRTRPWEEGVAASLTELFAPDLMRDRVAAFRKHYPWIKPEGHAYFTRRLPVVSSDSDRTLAIVLRHCATRERQEAALAALTFKCDVLWALADAIEHATACDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C6X8</accession>
    <name>A0A1H6C6X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase AhpD family core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68672">
        <property type="protein sequence ID" value="SEG68672"/>
        <property type="gene ID" value="SAMN04489712_10911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="178" mass="19003" checksum="46920E5F53489D4D" modified="2017-01-18" version="1">MTFIDHTIESAPPAARRSMEAVVKKLGYLPAGVARMSASPQLLDGFLRANGLFETTTLSPLAREVLVMTMATRNGCHICVALHSATLTSLGADPGLIAALRESRPLDDAPLEAMRRFVLEVLDTAGAVSAEAMEEFVGHGYTRRNALEVVLGIGVYTMSTLANRMTDAPLDAAMQPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C823</accession>
    <name>A0A1H6C823_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multisubunit sodium/proton antiporter, MrpG subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69111">
        <property type="protein sequence ID" value="SEG69111"/>
        <property type="gene ID" value="SAMN04489712_10950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="109" mass="11149" checksum="2B476232FA5C403F" modified="2017-01-18" version="1">MSVADLVTAVLLPAGAIFSVLGALGMARFPDLLTRLHAATKPQTIGLLLVLAGVAAQMHSISAVTPLVLVALFQLITSPVIAQTIGAVAYRTGEVDRGILTVDESGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8M7</accession>
    <name>A0A1H6C8M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69253">
        <property type="protein sequence ID" value="SEG69253"/>
        <property type="gene ID" value="SAMN04489712_10965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="127" mass="13938" checksum="1D7EF01120D21107" modified="2017-01-18" version="1">MDPAKGREEDELTPCTVPTGFFLLGLCGRASVASCAQCGRAVCGEHQEADGLCPECLAARSDSPPGPFDKGWSRRYRRDYYERIENVYDDGGWYSRLDAYDRGAFDPGDSHGGDDLIPDDDTSFVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9M3</accession>
    <name>A0A1H6C9M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69670">
        <property type="protein sequence ID" value="SEG69670"/>
        <property type="gene ID" value="SAMN04489712_109106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="301" mass="31295" checksum="9FFE08BE48C7590C" modified="2017-01-18" version="1">MHNGDAPVTVIGLGAMGAAMAEAFLKDGRPTTVWNRTAAKADPLVDKGAQRASTPAEALAAGELVVISQLDYPAMYDTFAGAEAALDGKVLVNLSSGTPQELREAAGWAAGHGARLVTGGIMVPPPGIGTPDSYVFYSGPEPALDTHRKTLETLGAVTYVGADPGLAMLYYQAMLMMFWSTLTSYFHAVALVGSAGATAEDLRPFAARLYGQLTGDGPMGFLPILTREIDAREYPGEQNSLHMQAVGAAHVVEAFRDAGLHTGMPGALRDLFAQADAAGHGAEGLTSVIEVIRDPQAASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAK5</accession>
    <name>A0A1H6CAK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69991">
        <property type="protein sequence ID" value="SEG69991"/>
        <property type="gene ID" value="SAMN04489712_109132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="27142" checksum="42D4CE7161036E53" modified="2017-01-18" version="1">MSGNCAWVIDGASDFRNERNLPAVSNVHWLVDRLQGALQTRGADGTVASGTLLLTEIQAEIVAELARHDLREMQQHPCCSLTLLVVHEDVLEIVRVGDAVGVLCGDSLELEISTGFFDAREAAAVEQARAQDLTMDEITSAMYRRRSEYIRGINGESVFSGHPDGNLFAHSLLVPRRRGAGFVVLLCTDGLARAVTEYRLFADWPALLNACLAKGVDAVITEMRAFEDAAESVAGKFKKSDDVAAVLLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCF5</accession>
    <name>A0A1H6CCF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70578">
        <property type="protein sequence ID" value="SEG70578"/>
        <property type="gene ID" value="SAMN04489712_109181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="30707" checksum="3C32D2915ADEA7B6" modified="2017-01-18" version="1">MKRLVYAGLGAMVLFTGGYLVVYTARWEWQRALMAGELLLVSLLVVVAVAGADRLNRLERRIAELSKADAAPPEPFSLPYGTPGVETPAFRWMRPEPDSYRVFIPVLLGAGIAVSGLAALVERIASSFGGRGTARRLASLSVPSGGVLAGGPDPARPERSPGRWLRPLLWSVIVALVAAVAVAELADHTQDRPDEPVHAAASTVVIQADANGQVPADLMARRLWEYCRGSTRPYLDQGGLTSIGGGRYALVVQPALGEYALRRLKGCLSDAVVDHGSFRVISVHPDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDS2</accession>
    <name>A0A1H6CDS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system, OmpR family, response regulator PrrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_109204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70785">
        <property type="protein sequence ID" value="SEG70785"/>
        <property type="gene ID" value="SAMN04489712_109204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG70785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="24169" checksum="2FF035E5757C9342" modified="2017-01-18" version="1">MGSNRRILVVDDDPAILRALRRGLTLEGFEVAVAECGEAALKGAAGADAIVLDVSLPDLSGIEVCRTLQDEGVQVPILMLSALDEVADRVAGLAAGADDYLVKPFDLTELALRLRALLRRAAPAGGRLRVGALVVDPQARRAVLGGRELALTRREFDLLEVLAFNAGMVLSRSVLLERVWGYDFQVTDNAVDTFVGYLRRKLEAGGEPRMLHTVRGVGFVLRAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMB1</accession>
    <name>A0A1H6CMB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="14" type="ORF">SAMN04489712_110155</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73793">
        <property type="protein sequence ID" value="SEG73793"/>
        <property type="gene ID" value="SAMN04489712_110155"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5014002777" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014002778" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG73793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="14278" checksum="8EDCBE4DB65C465A" modified="2017-01-18" version="1">MRRILMNGKIHRATVTQADLHYVGSLTIDAELMAAADIVEGEQVQVVDITNGARLVTYAITGEAGSGVIGINGAAAHLVQPGDLVIIISYAALDEEERRTHRPRVVHVDADNRIVALGNDPAEPVPGAPAQLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNS5</accession>
    <name>A0A1H6CNS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74136">
        <property type="protein sequence ID" value="SEG74136"/>
        <property type="gene ID" value="SAMN04489712_110192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="87"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG74136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="636" mass="67458" checksum="5BE498DC0226FBF6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQU7</accession>
    <name>A0A1H6CQU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75380">
        <property type="protein sequence ID" value="SEG75380"/>
        <property type="gene ID" value="SAMN04489712_11129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="8"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG75380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="42509" checksum="70A75675C617B896" modified="2017-01-18" version="1">MTTNDTAIRPFRIEIPQADIDDLRERLARTRWAADLPGTGWERGVPTAYLRELAEYWAGDYDWRVHEAALNDLPQFTTTIDGAGVHFLHVRSPEPEATPLMLLHGWPGSVVEFTDLIGPLTDPATHGGDPADAFHLVIPSLPGYGFSGPLPGPGWTDGRTATALTELMSRLGYERYGVQGGDVGAFVAPLMGRVAPEHVIGVHVNALVTFPTGDPADMAALTGAERERLALMKQWQEKMGAYLQLQGTRPQTLAHSLTDSPAGQLAWIVEKFKDWTDPAADLPEDAVDRDRILTDVGVYWFTGTAGSAAHTYYERFNDPAMWAPSGRSPVPTGVAVFTTDVSIRRFAEKAHNIVHWSEFDRGGHFAALEAPDLLAGDIREFFRTLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUG1</accession>
    <name>A0A1H6CUG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76437">
        <property type="protein sequence ID" value="SEG76437"/>
        <property type="gene ID" value="SAMN04489712_111164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG76437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="32" mass="3490" checksum="0FA0BD95B26FDA98" modified="2017-01-18" version="1">MVRTSIDRLVVIVFRAVSTSTVSVNSVRSRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVU4</accession>
    <name>A0A1H6CVU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rod shape-determining protein MreB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77112">
        <property type="protein sequence ID" value="SEG77112"/>
        <property type="gene ID" value="SAMN04489712_111250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG77112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="28491" checksum="272885C956ACD18C" modified="2017-01-18" version="1">MVPGPLLDSARRPCPRAAVDLGSSRVRASLPGLDVIVDLPSSVGAAAGRPPSPDTVRVGPIRYGAVTDVPGCIRLTRRTLREIDPMPELSEVLLGVPVAADRFQRHRAATAVQAATDCPVHTMQAPLAAAAGAGLDIADPRPRLVMDIGAGIIETVVIARARVLSARSIQYDPERVAGRPVPHLSEHLRERLAVTVHQVLGDLPSQQRVAARKGGLLLTGGGARMPSLPGRLTAEIGLTISVARDPSRATIRGLARICLSPAAWRQVVTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CXA3</accession>
    <name>A0A1H6CXA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77056">
        <property type="protein sequence ID" value="SEG77056"/>
        <property type="gene ID" value="SAMN04489712_111242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="21603" checksum="A2E377212E0AF3BF" modified="2017-01-18" version="1">MQVAIPLYPRFTALDAVGPYTVLAFAPGWTVTFVAAEPGPVTDDRGSLTLTATAAYADLPRPDVIVVPGGPGTLEALEDRALVDWIAQAHEHTRWTTSVCSGSFLLGAAGLLEGLKATTYWALLEQLAEMGAEPVNERFVAEGRIVTAAGVSAGIDMALALLALAAGEPTARAVQLAIEYDPRPPFDSGSALTASADLTERALKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZ75</accession>
    <name>A0A1H6CZ75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-hydroxybenzoate polyprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78312">
        <property type="protein sequence ID" value="SEG78312"/>
        <property type="gene ID" value="SAMN04489712_11261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295392" evidence="5">
        <location>
            <begin position="31"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG78312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="28978" checksum="4E6980D75214C027" modified="2017-01-18" version="1">MSAFSSEVLVRPARRLAALLRSCHPEPAVAVTVLLTALAVAAGRGPAGSAAVAAAVLAGQLSVGWCNDAADAERDRAAGRRDKPVAGGEISSRTVAVAARTALVLCVPLSLLSGALAGTVHVMAVLAGGWAYNLWFKRTVLSPLPYALAFGAVPAFITLGLPSHPWPAWWVMTAGALLGVGAHLVNVLPDIEDDLAAGVRGLPQRLGRTACRWLAPFVMLTAVGVLVAGPPGPVDALSGTLAGAAAIIAIAGTALPSGARGRRPFRAAIAVAGLAVMLLLLRGSDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2J1</accession>
    <name>A0A1H6D2J1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_112191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79264">
        <property type="protein sequence ID" value="SEG79264"/>
        <property type="gene ID" value="SAMN04489712_112191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="8">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="9">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG79264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="170" mass="18689" checksum="2081CB8356E51408" modified="2017-01-18" version="1">MGSTADERLLRALYAEHGGPLLGYALRLTGGDRQQAEDVVQETLVRAWRHPEALTGRPVRPWLFTVARNLVVDAHRARQSRPPETGLHEHAALPDGGDDIDRALESWMVAEALADLSPPHRAVLLETYYRGRSVAEAAKVLGIPAGTVKSRTYYALRALKLALEERGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4J4</accession>
    <name>A0A1H6D4J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monosaccharide ABC transporter ATP-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80252">
        <property type="protein sequence ID" value="SEG80252"/>
        <property type="gene ID" value="SAMN04489712_11350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG80252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="512" mass="54892" checksum="790C07B3C0644A93" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5I8</accession>
    <name>A0A1H6D5I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80637">
        <property type="protein sequence ID" value="SEG80637"/>
        <property type="gene ID" value="SAMN04489712_113119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025333">
        <property type="entry name" value="DUF4239"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14023">
        <property type="entry name" value="DUF4239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295534" evidence="2">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="27041" checksum="CECBD0C2357B47D7" modified="2017-01-18" version="1">MVVYVLAAVSAVGVVLLASRLVRGTPDPDPDGPTVGHTGSMVSALFLLAFAIAIVVPWTTIDAARQNTYAESQAVAEAYWSAALLPSPVRERTQMGLRDYVELVRGQEWDLMADGRLSGEGWARLERMRREVTALRAEEDEAREHRTAVLDHIREISAARRQRAMDAATAPPPGLLVITVLTGLVVVFLPFLSGARPRGMTLVPLTLMSALLAIGIYLVFDISQVFSGALAVQPDAFTGVLPELRRISAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5Y3</accession>
    <name>A0A1H6D5Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80398">
        <property type="protein sequence ID" value="SEG80398"/>
        <property type="gene ID" value="SAMN04489712_11374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="216" mass="24160" checksum="4880786C001268F1" modified="2017-01-18" version="1">MPPFLPTLARRAAGEVERLLSSLAAQGQELLLQAQGGDRRDEIARLRAETAAQRERADRLERLLAEQSAGLAAVERQMESLVTELNGRLLPGLDERMHETERDLARLATRMLRAGQEAVRHQSRLTAVEQRLVDLRERAGRLEQRTGIWRELQANVARLGEELDALRARGTAETAELPVLEDGGLRGLDNGELRELDGKGRNTISLDRSTQEDLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D698</accession>
    <name>A0A1H6D698_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_113171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80889">
        <property type="protein sequence ID" value="SEG80889"/>
        <property type="gene ID" value="SAMN04489712_113171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG80889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="354" mass="38331" checksum="DEA808CB64F12F38" modified="2017-01-18" version="1">MPDPVEWGRVLAGVIVVASALLVGIVLRTLLRRLTERAEDTRWAWDDLLVRLLRDLAVVLTTTAGLWAAVLTVRFQPGTREVIASVLIAVIIMAVTLASARLAAGIVTSVALARSGVAQSVTIFANITRTVVLVVGTLVLLQSMGVSITPMLTALGVGGLAVALALQDTLANLFAGVHILASKTVEPGDFVRLSSGEEGNIVDINWRNTTIRTMSDNLVVVPNARFADVILTNFHGPEQEMGILIAAKVAYDSDLEQVEKVTIEVGSEVMTEVEGGVPEYQPLVRFHTFGESGIDFTVILRTREFNDQFVVKHEFVKRLHARFRAEGIRIPLPTRNLVFAEGRDAVPLPAHPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8Y2</accession>
    <name>A0A1H6D8Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tn3 transposase DDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_114143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81790">
        <property type="protein sequence ID" value="SEG81790"/>
        <property type="gene ID" value="SAMN04489712_114143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002513">
        <property type="entry name" value="Tn3_Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01526">
        <property type="entry name" value="DDE_Tnp_Tn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DDE_Tnp_Tn3" evidence="7">
        <location>
            <begin position="413"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG81790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="645" mass="70556" checksum="BCEF1C8610B1D616" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9L4</accession>
    <name>A0A1H6D9L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81868">
        <property type="protein sequence ID" value="SEG81868"/>
        <property type="gene ID" value="SAMN04489712_114162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="21787" checksum="39250939C6771CEC" modified="2017-01-18" version="1">MRKLVYYIAATLDGFIAGPDGADPTGPGGFWPIPDDYLQHLIAEYPETLPGPARQALGITAEGTRFDTVLEGRHSYEIGLKAGVTDAYPHLRHLVFSRTLSKSPDPAVQIVSGDPVAAVHELKEQDGKDIWLVGGGTLAGALYPEIDQLVIKLAPLTVGTGIPLFGRAATFDPRTWQLTDQTALSSGALFLTYTRIPAEHEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCY5</accession>
    <name>A0A1H6DCY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82653">
        <property type="protein sequence ID" value="SEG82653"/>
        <property type="gene ID" value="SAMN04489712_11557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295769" evidence="2">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="32666" checksum="F99DDB96B028053B" modified="2017-01-18" version="1">MGSTAGILTAGTALLLTCGACASTEEPPRASPPVERPTTAAGSNAPRHEAVLEDPNPAQRPAGIDQQLRSPVGGGGDPCYEQQKFSLQTPYETEAQEYGYPDAPDPREPHTDSIPFHGSFCVVGSDRSRQVTVTLTSPSGKVLKRRDLPPEYDQSASEQVTDREQFDMRFLPGDEEGAYTLTAAQGDRRATRKIEVTRAAKPRIFLVTDPPSDGAFTRTGTGRITFAFGGLPTTGPTDFYLYHSGSGAQQDGFLTRNFHSTYKVTGGPTGTAFLDLRITPSAQAGYYYLVNPKWGTGVLWQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEL8</accession>
    <name>A0A1H6DEL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine dioxygenase, alpha-ketoglutarate-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83828">
        <property type="protein sequence ID" value="SEG83828"/>
        <property type="gene ID" value="SAMN04489712_11676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="7"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG83828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="31051" checksum="B5811F553EDE82C3" modified="2017-01-18" version="1">MAVIAMRRLGETVGAEVLDVDADRLLNDDGLPAACMRGLEEHGVLLFRGLRIDDHAQVAFCRKLGELARFPNYPIPEVMEISFDPDNPNAEYFASNDHWHIDGALDEVPAKASAMSAHVVADEGGETEFASTYAAYDALSGEERARYAELRVVHTFEAIQRRTYQDPAPEQLAEWASRAVREHPLVWEHRSGRRSLVFGATASHIVGMDVEEGRALLTDLERRATTPDRVFRHTWSVGDMVIWDNRGLVHRACPFDRRQPRRMHRTTLVGDEPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF90</accession>
    <name>A0A1H6DF90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83894">
        <property type="protein sequence ID" value="SEG83894"/>
        <property type="gene ID" value="SAMN04489712_11695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="86" mass="9483" checksum="668EE29F04E1E751" modified="2017-01-18" version="1">MTDCDLSALRERADNGDQDAVDELIELAAEHGDLEQLRYLADQGNTTAADQLIELATEHGRLEELRRLAEKGNTTAADQLMELTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHC9</accession>
    <name>A0A1H6DHC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p-aminobenzoate N-oxygenase AurF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84591">
        <property type="protein sequence ID" value="SEG84591"/>
        <property type="gene ID" value="SAMN04489712_11730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG84591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="369" mass="42948" checksum="9772CFF22A73145B" modified="2017-01-18" version="1">MSTHELYTAPVGEQTWDVPMTGDARFAWEYDDGRDRLLALYQKGKDKQWDSVKRIDWDLEVDPHDVFGVPDQSLAIYGTRYWDMMSERERAELRRHQASWQFSQFMHGEQGAMITGARIVETVPDLDAKFYSATQTMDEARHVEIFSRFLQEKVGLVYPINPNLQNLLNETLGDSRWDMPYLGMQVLIEGLALAAFGVIRDITTKPLPKQILSYVMQDEARHVAFGRMALRDHYKQLSAAELREREEFVIEGCYLMRDRIRGREVWTNFGIDPREVDQLVNESSYVRMFQSLLFSRIVPCVKDIGLWSERIQRAYDDMGVLEMSKSDLEALMRNDEDLADRLDAERFATEEAERKAEVHAVIDEARTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIF3</accession>
    <name>A0A1H6DIF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LAO/AO transport system kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_117120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85040">
        <property type="protein sequence ID" value="SEG85040"/>
        <property type="gene ID" value="SAMN04489712_117120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="42"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="29243" checksum="17B250CAB670E1C9" modified="2017-01-18" version="1">MDVPELVTAAGKGSPRAVGRLLSLVEGARREEVLAALGPADPARVVGVTGPPGAGKSTTVAALVGAYRERGLRVAVLAVDPSSPYSGGALLGDRIRMAAHTTDPGVLIRSLATRGHLGGLAEAVPAAVRVLAALSYDLILLETVGVGQSEVEIAAVADPTVVILTPGAGDAVQAAKAGLLEVADLLVVNKADRDGADQTVRELRIETGTPVLTLVAAKGEGLPALVEAIDAHYRADTLARRTARARAQILSLAQTRLRAHPGLAGLAADVAEGRLDPYAAAERLFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJD4</accession>
    <name>A0A1H6DJD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted N-acetyltransferase YhbS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84756">
        <property type="protein sequence ID" value="SEG84756"/>
        <property type="gene ID" value="SAMN04489712_11763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="21583" checksum="B9748EDD64349E11" modified="2017-01-18" version="1">MTGHRPPGHPRHATGVRPRPQTSTETDPNPAMTVSWTTRPETAADLAQIREVNLAAFPTPHEADLVEALRADPQAWIPGLSQIAEAPGGGIAGFALLTRCHVDDAPALTLGPCAVRPEHQRQGAGSAAIRAVLRAAREQGENLVLVLGHAEYYPRFGFTPASDHAIRPPFDVEDKYMMALAFDPTRPVPAGTIHYPKAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKD2</accession>
    <name>A0A1H6DKD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_117145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85136">
        <property type="protein sequence ID" value="SEG85136"/>
        <property type="gene ID" value="SAMN04489712_117145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG85136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="189" mass="21510" checksum="657AEBE4556265C0" modified="2017-01-18" version="1">MGNTRREEILEAAMDLFAEHGYRGASLDQIAERVGLTRQGLLHYFPSKKKLLIALLGRREELNREHLVADHLAEKDWPTQVAEAVAFDREHPALARIHTILMAESLTEGHPAREYFRDHQRTVREHITRRLSERYGDRLPSGLSTQAAAAALLALIEGLQQQWLLDLDQTDHPEVMRSVWSVLLGPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL39</accession>
    <name>A0A1H6DL39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="3" type="ORF">SAMN04489712_118123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85982">
        <property type="protein sequence ID" value="SEG85982"/>
        <property type="gene ID" value="SAMN04489712_118123"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="237" mass="25664" checksum="C83580EE2A414015" modified="2017-01-18" version="1">MSSNDSIKIVWVYPDLLSTYGDQGNCIVLERRAALRGIRTRTVHVRSDETVPVDGDIYLLGGGEDRPQILAARRLHGDGGLHRARDFGAVIFAVCAGYQLLGTEFGGEEGQPVQGLGLLDIRSSRGQQRAVGEIVGDVDQALNVPRITGFENHQGVTHLGPGVKPLARVVHGIGNGDGHEGAYQGHVIGTYMHGPALVRNPGLADLLLRWAVKHDLPPIAESWSERLREERLRVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMK7</accession>
    <name>A0A1H6DMK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86371">
        <property type="protein sequence ID" value="SEG86371"/>
        <property type="gene ID" value="SAMN04489712_11964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG86371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="161" mass="17678" checksum="2B8A84112A0DCD1F" modified="2017-01-18" version="1">MRTPQRTILREPHELLDLVGRELGASEVRVVTQEEIDRFADVTGDHQWIHVDVERAKAGPFGGTIVHGFLTLALVPRLLEDILTIESFSMGVNYGLDRVRFVKPLPPGTEIQGVATLTSAERISVGDDGSEGVQAKASVVVEFANDATTCCVAEILFRYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNL5</accession>
    <name>A0A1H6DNL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ORF">SAMN04489712_12012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86828">
        <property type="protein sequence ID" value="SEG86828"/>
        <property type="gene ID" value="SAMN04489712_12012"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="288"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="225"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG86828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="40759" checksum="00335FFAA7431B32" modified="2017-01-18" version="1">MSMIAEDAAVRGVREAIAGARRVVVKAGSSSLTTPQGAIAADRIDALVDVLAAGKSAGRDIVFVSSGAIAAGLGPLGLTRRPPDLATQQAAASVGQGLLVARYTSSFARHGMRVGQVLLTADDMMRRAHHRNAQRTLEQLLALGIVPIVNENDTVATDEIRFGDNDRLAALVTHLVRADALILLSDVDALYTGDPRRPGTRRITEVRGPADLTEVELGGSGRVGTGGMVTKVEAARIAGGASVPVVLTNAASAAAAMAGEPVGTYFHPEARRPSTRLLWLAHATTGQGRLLLDPGAVDAVVRRRKSLLPAGLTGVEGDFNAGDPVDVVDGNGRVVARGLVNYDAGEIPSLMGRSTRWLARELGPEYEREIIHRDDLVILDRRQGEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DR91</accession>
    <name>A0A1H6DR91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">16S rRNA (Guanine966-N2)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87135">
        <property type="protein sequence ID" value="SEG87135"/>
        <property type="gene ID" value="SAMN04489712_12074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="187" mass="20064" checksum="59259940404926BC" modified="2017-01-18" version="1">MSRVIAGIAGGRRLVVPPGRDTRPTSDRAREGLFSTVGALLGPLDGLRVADLFAGSGAVGLEALSRGAAHALLAESHPRAVKVIRQNIAALGLSGAELVADRVERLLRRPPAEPYDLIFLDPPYAVTDETVTGLLEALRDHRWPAGDALVVVERAARGPALRWPDGYAPERDRRYGEAVFWYGRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUV0</accession>
    <name>A0A1H6DUV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89162">
        <property type="protein sequence ID" value="SEG89162"/>
        <property type="gene ID" value="SAMN04489712_12334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="330"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="423" mass="45448" checksum="E29B116F9034A257" modified="2017-01-18" version="1">MSEYPTDRHPRRAGFSDAALRQAVLDAAVRAPNEPPRVLMPGRRWVRWLELLLVTAMAVGFTGGTIAIPLNIFDPRPPAMLAVVLALMQAAPLAFAPRWPLAAWRISALGLLAGALLLREDYFWPWPVTSWLAFVVILFFTAVGYDRPVAVGAGLVSVGGLIVPGVVVAGMPDWFGLILAGIVVLVLAFGDAVGGRYTAELSLAEQEALRRQDLARQARLEERARIARELHDVVAHHMSVIAMQAEAAPYKIPDLPDAARDTFALVRDAARDALTETRRVVGLLRSEDEGAERRPQPGLERLEELVSGARRAGLSVDAAIVGVPRPVSAGVDLSAYRIVQESLSNASRYAPGARVWVEVRYGRRTLAVSVTDDGPRTSPAEPGGGHGLVGMRERVAMLGGTLSAGPAEPRGWTVVAELPYGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWA6</accession>
    <name>A0A1H6DWA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phage integrase, N-terminal SAM-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89617">
        <property type="protein sequence ID" value="SEG89617"/>
        <property type="gene ID" value="SAMN04489712_1246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="71"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="220"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG89617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="449" mass="49865" checksum="7327FD9F3362E4E0" modified="2017-01-18" version="1">MAKGNKPGRRRFGNVRKLPSGRFQASYIGPDGQRRTAPETFERKSDAERWLTLTEAQIFNGDWTDPQRAKVKLGDYAAKWIEQRPGLRPRTVELYQWLLRKHIAPYLGGVELGKLSTSMIRGWRADLLAAGVSATMAAKAYRLLRAVLMTAVDEDKILTRNPCRVRGAGTEHAPERPVLTVAQVFELAERVGVRPVGNFRKLDSGEYRLRYRVKGGTMRRFPHTFVTRAEAERALWKLAEDGHADTVRDDRLRAFILLAAFASLRWGEITALRRCDIDTENRTVRVRAAFVERDNGQMILGPPKSRAGLRTVSIPAAIIPDLVAHLDKYTGKGGDALVFTGVKGGPMRRSGFNKVTRWTHVVRAMGVPGLHFHDLRHTGNTLAADMGVSLANLMARMGHDNERAALRYQHRSKSADRAIADGLDALVQVQQAKGGDDEDGAAGKLVPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYE4</accession>
    <name>A0A1H6DYE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-oxo-dGTP diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89793">
        <property type="protein sequence ID" value="SEG89793"/>
        <property type="gene ID" value="SAMN04489712_12467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="25513" checksum="CD886F785AB8FCDA" modified="2017-01-18" version="1">MTVPRVAVSVDLVVLTVREQRLCALTWRRDRPPYHGCWSLPGGFVHLDEDLPVAAFRLMAERAGLADVRIHLEQLATYGYPDRDPRQRVVSVAYLGLAPDLPASSRAQVLWTPVDDLVDRDRAAFDHRRILRDGIERARAKLEYTSLAAAFCPPEFTVAELRRVYEIVWGTPLDPRNFHRKVTGADRFLIPTGRTTTRDGGRPAQLYRRGDAEQLRPPMLRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZQ9</accession>
    <name>A0A1H6DZQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90701">
        <property type="protein sequence ID" value="SEG90701"/>
        <property type="gene ID" value="SAMN04489712_12713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="36"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="17991" checksum="831F339F90C55A02" modified="2017-01-18" version="1">MIGDLDWVPAADHPDLLAEPVRTALVPQAQVAGIDPELADTAAFCERYGVPLGVSANCVIVAAKRGGEIGMAACMVLATHRADVNGVVRRHLGARKVSFAPMEEATRLSGMEYGGITPLGLPPEWPVLVDEAVAAEPYVVIGSGLRRSKLLVPGKALAALDPAEVIALGRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E014</accession>
    <name>A0A1H6E014_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90326">
        <property type="protein sequence ID" value="SEG90326"/>
        <property type="gene ID" value="SAMN04489712_1263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="324"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="390" mass="42093" checksum="24D9DE395C930352" modified="2017-01-18" version="1">MLCAAARRIETATLGRQMRGTVVEEVERALNAGEPHVNPDAMWLTLLALHYTGDFDAVKAYCDELSRDPDWMRASRRRELVLMMRARVALEGRAMGSAAEMLRSVLADMGPGPLRTLAVAWLIESLVRAGEFDQAHEVLLAHGLTGRLACGTAERAHVLAARGNLRLATGHFQLGLDDYLACGRLLKSLNVANPAVIPWRSMAALGALATHRCDLARVLAEEELVAARRWGSPRAIGAALHALALARRDESSAAMLEEAVELLYLAQAGTELIQALYDLGTLRIQQGNVPEGRTGLAAAAAVARECGSAYWTARTETALARSGEGNAAQALTPQEARVANLARAGYSNRKIAETLFLTVRTVEFHLSSVYRKLGISGRRELSAVLSLTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E037</accession>
    <name>A0A1H6E037_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG90968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90968">
        <property type="protein sequence ID" value="SEG90968"/>
        <property type="gene ID" value="SAMN04489712_1282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="6931" checksum="AB807DDDC53E9182" modified="2017-01-18" version="1">MDGISHYWADRRTTLLRLARLVGKGEFAELGDGAAAPAGTGAYALDQSWHIGWLFAAALIACLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E411</accession>
    <name>A0A1H6E411_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase DDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_13156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91983">
        <property type="protein sequence ID" value="SEG91983"/>
        <property type="gene ID" value="SAMN04489712_13156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="3">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG91983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="19174" checksum="5DC3BC2C845F85F0" modified="2017-01-18" version="1">MRDRLRQRASAQRGDLTGPNRLDRGKNGSKIHLITERTGLPISVAISAANLHDSQVLQPLIRGIPPIRSRRGPRRRRPAKLHGDKGYDYDHLRRWLRTRNITPRIARKGIESSARLGRHRWVIERTIAWLAGCRRLHRRYERKADHFLAFTAIAAALVCYRRLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E547</accession>
    <name>A0A1H6E547_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Broad specificity phosphatase PhoE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92106">
        <property type="protein sequence ID" value="SEG92106"/>
        <property type="gene ID" value="SAMN04489712_13226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="25031" checksum="00FD37ECB0E7E14C" modified="2017-01-18" version="1">MINVRRVWLIRHGQSESNAGLPTNGPGASPLTALGRQQAARTAAAFTAPPELIVSSSFVRARQTAEPTVERFPEVPYEEWPVQEFTYLGRLHGAQTTTAQRRPFAEAYWQRADPAYVNGGDGESFTALITRVRAFLDRLADRPEEGTIAVFTHGIFMKAVIWSLFTGVTDPDATAMSGFRHFNGACDIPNCTVTELWRPSGPYGFRVVGGGTTHLADTSTAQGTASSAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5Q1</accession>
    <name>A0A1H6E5Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_13438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92573">
        <property type="protein sequence ID" value="SEG92573"/>
        <property type="gene ID" value="SAMN04489712_13438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="247"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG92573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="437" mass="48629" checksum="F693EB19C2950E33" modified="2017-01-18" version="1">MAWDFETDPDYQKLLDWADAFVRDEVEPLDLVLGDPYDKADPRHRALVRPLQQQVRDRGLWACHLGPELGGQGYGQVKLALLNEILGRSRWAPSVFGCQAPDSGNAEIIALFGTPAQQERYLRPLLDGEISSSYSMTEPHAGADPTLFTTRAVRDGDEWVINGEKWFSSNAKHAAFIIVMAVTDPEVSAYEGMSMFIVPAGTPGLEIVRNVGVGPGHEGREGSHGYLRYNDVRVPADHLLGTEGGAFAIAQTRLGGGRIHHAMRTIAQVRRAFDMMCERAVSRQTRWGPLAKLQLTREKIADSWIEIEQFRLLVLRTAWLIDKHRDYRRVRKDIAAVKAAMPKVLHDVVQRAMHLHGALGVSNEMPFAAMLLGAEALAIADGPTEVHKITLARQLLKEYEPVPGLWPTAHLPTRRAAARERYAETLEEALEHAIGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E692</accession>
    <name>A0A1H6E692_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monosaccharide ABC transporter substrate-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92486">
        <property type="protein sequence ID" value="SEG92486"/>
        <property type="gene ID" value="SAMN04489712_13412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296590" evidence="1">
        <location>
            <begin position="24"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="45"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="361" mass="38031" checksum="EA9BA568D2C6A176" modified="2017-01-18" version="1">MRKGILSVAAISVVAALTLTACGDDSGDDAEGGQVGAVKGKVGVILPDTKSSARYESFDRPYLAEAFKAAGVQYDIQNAEGSAQRFQTIADQMITSGVTVLLIDGIDSNSAAAVTRKAQQQGVKTIDYDRLTLGGVSDYYVSFDNVKVGEELGKGLQKCLGDKDANIVYLNGAPTDNNATLFAQGAHSVLDKVSGYKKVAEQAVPGWDNQRGATIFEQMWTQQNGKIDGVLAANDGLGNAAVSILKKNKVAGKVPVTGQDATLQGLQNVLDGTQCMTVYKPIKQQADAAAKLAISLLKGEKAETNGTTKDTEGNRDVPSVLLTPIGIFKDNVKQVVDDGFVKQEELCAGDYADKCKEAGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E727</accession>
    <name>A0A1H6E727_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92756">
        <property type="protein sequence ID" value="SEG92756"/>
        <property type="gene ID" value="SAMN04489712_13521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="74" mass="8029" checksum="5605A78801FF742D" modified="2017-01-18" version="1">MGRARWTIEVDRRRCIGNQMCVNVAGDHFVLDQGKSRPVANPVAPSDDVLEAVELCPHSAITVRDESGGLVEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E755</accession>
    <name>A0A1H6E755_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-ketosteroid 9alpha-monooxygenase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93648">
        <property type="protein sequence ID" value="SEG93648"/>
        <property type="gene ID" value="SAMN04489712_1403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="258"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG93648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="36472" checksum="76A5437A71A05B3C" modified="2017-01-18" version="1">MNETGPCTVTVLDVVEETADACSLVLGVPGELRDGFAYRPGQFLTLRIPGAGGAGLARCYSLSSAPGVDPHPKITVKRVAGGAGSNWICDNVRPGHTIDVLPPAGLFTPGRLTGDHLFFAGGSGITPVISIIKAVLAQPEGTAVLCYANRDESSVIFAAELRDLVARHPRRLQVIHWLESVQGLPTADALAALAAPHADRDAAFVCGPEPFMDAVAQALRSVGMPGDKVVVERFRSLTGDPFADPAPLPAETGDVTAVRVTVTLDGDRHSFPWPSQTPLLDLLLSKGIRAPFSCREGACSACACRVTAGEVKMLRNDVLEEEDLADGWVLGCQSVPVSEDIEVTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7Y2</accession>
    <name>A0A1H6E7Y2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93938">
        <property type="protein sequence ID" value="SEG93938"/>
        <property type="gene ID" value="SAMN04489712_1421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="14653" checksum="DBF725BAEC014249" modified="2017-01-18" version="1" fragment="single">MTQIRGLGYLKVQTRHIERWRELAIDGLGFAEGSGPDPDGLYLRMDERRHRLAVLPGETDRVLAVGWEVRDQYALAAVREAVDKSGTQVTELSAAQAAERDAEQVIAFTDPAGTPVEVFFGPVLDHSPLRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E922</accession>
    <name>A0A1H6E922_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P) transhydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_14610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94318">
        <property type="protein sequence ID" value="SEG94318"/>
        <property type="gene ID" value="SAMN04489712_14610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="344"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG94318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="467" mass="50583" checksum="94B34DF4C3A972C1" modified="2017-01-18" version="1">MHDFDILVLGSGPGGQRAAIAAAKLGRRVAVVDRRNMIGGVCINTGTIPSKTLREAVLYLTGLNQRELYGQSYRVKEDITVTDLGMRTQHVIGREVDVIRSQLARNRVTVLTGTGRFLDPHTVGVTDGGDHERRVTADRIVIATGTRPARPETVEFDEETIIDSDGILRMDRVPSTMVVVGAGVIGIEYASMFAALGTKVTVVERRERMLEFCDLEIVEALKYHLRDLAVTFRFGETVKAVEKRPRGAITVLESGKRIPAETVMYSAGRHGMTGDLGLEAAGLSADGRGRIAVDERYRTAVPHIYAVGDVIGFPSLAATSMEQGRLAAHDACGEPVSGMHALQPIGIYTIPEISFVGRTEDELTADKIPFEVGVSRYRELARGQIIGDSYGMLKLLVSPQDRSLLGVHVFGTGATELVHIGQTVMGCGGTVDYLVDAVFNYPTLAESYKVAALDAMNKMRQIALLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E997</accession>
    <name>A0A1H6E997_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93699">
        <property type="protein sequence ID" value="SEG93699"/>
        <property type="gene ID" value="SAMN04489712_14016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="26848" checksum="60F27DC718CE441F" modified="2017-01-18" version="1">MALKIDLTDHVVLVTGGTRGVGAGIARTFLEAGAAVEICGRTAPGPAPAVPRFSQVDVRDEDQVRHWVDEVAGRHGRIDVVVNNAGGAPFTGFADASPRFHRRITDLNFLSAVFVAQAAYPVMSAQDAGGVVLNITSISARRPSPGTVVYGAAKAALESLTRSLAVEWAPRIRVNAVSSGLVETEGSADHYGGPEQVARVAATIPRGVFAKPADIGAACALLASPLAAHITGAILNVDGGGEWPAFLQHAPGTEKLPGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBX1</accession>
    <name>A0A1H6EBX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94275">
        <property type="protein sequence ID" value="SEG94275"/>
        <property type="gene ID" value="SAMN04489712_1457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="11525" checksum="56C79975F97F49BC" modified="2017-01-18" version="1">MSNGFPDGEFCIINEATGLYLAALPGGTITGSQQETDWLERTRETVHYTHTANQVLGLATEPSGKNYERWFLDDRKNSWGQEHYHLVNYARTSAPGTPWPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EC58</accession>
    <name>A0A1H6EC58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000053">
        <property type="protein sequence ID" value="SEG94853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94853">
        <property type="protein sequence ID" value="SEG94853"/>
        <property type="gene ID" value="SAMN04489712_1532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="966"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1510"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1001"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1843" mass="198091" checksum="2E11D4444F14009D" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SHR9</accession>
    <name>A0A1H5SHR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49331">
        <property type="protein sequence ID" value="SEF49331"/>
        <property type="gene ID" value="SAMN04489712_101188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284049" evidence="1">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="12331" checksum="AEA70FFEF7964EA1" modified="2017-01-18" version="1">MTRRTAPAALALAAALLSSLTACGGDGEPSAPSGHPFTGTWLGAGGAGTGAGGTTLTVDENGGVRFKSTVDCTGTTAPAGEAYRFDIDCKISKFTGTARPPKGAKTFVMTWSEGDTTEFRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SLG1</accession>
    <name>A0A1H5SLG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50798">
        <property type="protein sequence ID" value="SEF50798"/>
        <property type="gene ID" value="SAMN04489712_101240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284123" evidence="2">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF50798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9448" checksum="DBA16F2991C2DFC4" modified="2017-01-18" version="1">MLKRLATVGVLTATASGMIMGAVPAMAGDSAPDSGRSRKHQKSPRNNCTNFGENRRLWHSLEAFEFHNFVVGNGHHVGITNNRCKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SPP6</accession>
    <name>A0A1H5SPP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52400">
        <property type="protein sequence ID" value="SEF52400"/>
        <property type="gene ID" value="SAMN04489712_101304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF52400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="199" mass="20266" checksum="33E29116E8F33E27" modified="2017-01-18" version="1">MGRPGVRGLRIWAVTTVLLAVLGPPAGLLWAAIAPPVRYLMLDGHLVLADPETQALIAGDGRYALVTGAAGVLCGVLAYLAGGRDNDVPLLLGLGTGGTAAALLAWWTGHRVGQGGFEEAVRAAAGRAVESPADLHAVGVVVSWPLLAVAVYGVLEAVLARLAPRDRGQDGAGEPDEVGGGQLDLQAAPPRGDQDRVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T2C2</accession>
    <name>A0A1H5T2C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent oxidoreductase, nitroreductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56904">
        <property type="protein sequence ID" value="SEF56904"/>
        <property type="gene ID" value="SAMN04489712_101454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF56904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="18422" checksum="45B1D8FD9EDFF18E" modified="2017-01-18" version="1">MPDDRTPPPGRPKGLDSPLVPKILKVASRLNVAVYRATGGRIGGTWRVGSAFPRGVPVCLITTTGRKSGLPRTLPLLFMPDGDRVILVASQGGLPRHPLWYLNLTADPEVRVQVKRDVRRMRARTADETERAGLWPRLVAMYADFDRYQSWTDRRIPVVICEPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T7R8</accession>
    <name>A0A1H5T7R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase conserved C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58141">
        <property type="protein sequence ID" value="SEF58141"/>
        <property type="gene ID" value="SAMN04489712_101495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="857"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF58141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1171" mass="130196" checksum="BA9EB1FDA4C1096B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TC73</accession>
    <name>A0A1H5TC73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60442">
        <property type="protein sequence ID" value="SEF60442"/>
        <property type="gene ID" value="SAMN04489712_101564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF60442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="27010" checksum="6F4FD6F94924CAC3" modified="2017-01-18" version="1">MTAWQTIRLDTPHEGVRRITLADPDRRNALGTVMREELIAAVASVRDDADARVLVVAAEGTSFCAGADLPVLFGEPGRPVGEIRQGLRSYYESFLVLRDLAIPTIAAVQGPAVGAGLNLALCCDIRIAGPEARFAATFSRIGLHPGGGCTYFLTRELGPQRALALLLEGGALSAEQAAERGLVLSIAADPAAAALELARRHARLRPALARDIKQAVRLAAGGDLEAVIEFESWAQAESATHPEITEFAARFAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TPK0</accession>
    <name>A0A1H5TPK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64724">
        <property type="protein sequence ID" value="SEF64724"/>
        <property type="gene ID" value="SAMN04489712_101701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF64724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="33564" checksum="B4EB4259E0750431" modified="2017-01-18" version="1">MDDEGASTAASRLDRLASVNLNLLVPLLAVLEERSVTRGAERVGLSQSAMSHALGRMRRLLGDDLLVRQGNGVTLTPRAMELIAPLRATLQQAADVINFPGFDPATDRRVITIAMTTSTAFVLGARLGRLVAERAPNATLRLRTITVPTESTFTEHGVDVVLLSEGIASPYPRERLYDDRCVVVASADTPPEASALELLTTQPHVVVDTERRVFPYSVLDERGVTYRVGQLISDFLLVPYLVGRAGGVALLRFRVASEMRTLVGLRIEEFPFPLPGLGIDMVWNPHLGDHHFIAWLRQLLFDAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TPM3</accession>
    <name>A0A1H5TPM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63967">
        <property type="protein sequence ID" value="SEF63967"/>
        <property type="gene ID" value="SAMN04489712_101679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="18"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF63967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="299" mass="33121" checksum="C0E9C99AF95D671D" modified="2017-01-18" version="1">MNDLAITPSIDVDRLTAIDVHTHAEISRDGHGSLSPELFGASEEYFKAHGHRQPTIAEMAAYYRERNMAAVVFTVDAEHATGWPRISNEEVAESCAAHPDVLIPFASVDPWKGRAGVREVRRLVERHGVRGFKFHPSIQGFSPDDPMAYPLYEAIEELGVPALFHTGQTGIGAGVPGGGGIRLKYSNPMLIDDVAVDFPELRIILAHPSFPWQDEALAVATHKPHVHIDLSGWSPKYFPPQLVRYANSLLKDKVLFGSDYPVITPDRWLADFDTLDIKPEVRPRILKDNAARLLGLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TU15</accession>
    <name>A0A1H5TU15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Muconolactone delta-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66250">
        <property type="protein sequence ID" value="SEF66250"/>
        <property type="gene ID" value="SAMN04489712_101744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026029">
        <property type="entry name" value="MLI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02426">
        <property type="entry name" value="MIase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF66250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="11350" checksum="139FA1714D54E449" modified="2017-01-18" version="1">MALFAVLATQHPVGISADEFRRRLPEGFAYTRSLVDKGVIKHSWVRVGASGGLLVYDVGSHEELLSLLYANPVSPHLEFEVIPLAQPTEFDPVAFAEQAGTSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TX98</accession>
    <name>A0A1H5TX98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">dTDP-4-amino-4,6-dideoxygalactose transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66647">
        <property type="protein sequence ID" value="SEF66647"/>
        <property type="gene ID" value="SAMN04489712_101757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF66647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="384" mass="42206" checksum="41B8B6B40DB3DADE" modified="2017-01-18" version="1">MINVFQPSLGEEELEAIREVFARNWLGYGPRTQAFETEFAAHLQVERDGVLFVNSCTSGLFMAMELLELGPGDDVVLPSVNFIANANAVAVTGAWPVFCDVDSRTLNPTVTDVERALTPRTKAVVVLHYGGHPGEIEGIAALCRERGVALVEDAACSIASSVNGTMCGTFGDIGVWSLDARKIITTGDGGVLRVRDPELARRAHRLAYHGMVDRSSFTAMADLRRRWWELAVQEIGRRSIGNDVTAAIGSVQLRRLAGFVARRRAIAETYDRLLAEVEGVRTPPPLPDGHVGSYYFYWVQLDAAIRDQVAEDLLDCGIYTTFRYPPLHRTSLYRSEARLPRTDEAAETTLLLPIHQGLTDEDVETVVGQLAKVVGNRGGGRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V3S9</accession>
    <name>A0A1H5V3S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81391">
        <property type="protein sequence ID" value="SEF81391"/>
        <property type="gene ID" value="SAMN04489712_102131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF81391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="36059" checksum="A870DBFA4D555FB8" modified="2017-01-18" version="1">MGRENGRVRASRLVSLVLLLQARGTMTAAELAQELEVSERTVYRDVLALSGAGIPVYAEQGRRGGYRLVDGYRTRLTGLSRAEAEALFLSGLPGPAEDMGLADAVATARLKVLAALPPSLQDAPARTGQRFHLDVGGWFGDAEPPPLLAALARAVWQDETVVLRYRRDREVTRTADPYGLVLKGGIWYLVALVGGDYRTYRVGRVTAVEPTGVSFERDETFDLRGFWAERAAQFVESLLTDAVTIRLSPAGARALRYSVEPPAARWALEAAGEPDERGWVVTRLPVESVDVAYTQLLRLGPEVEVLDPAELRERMAEAARRMGLLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V8H9</accession>
    <name>A0A1H5V8H9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83494">
        <property type="protein sequence ID" value="SEF83494"/>
        <property type="gene ID" value="SAMN04489712_102209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF83494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="29133" checksum="5ABF3C42E0EBAE76" modified="2017-01-18" version="1">MCGRYATTRARQELIEEFQVQLDATGDELRPDYNVAPTRMVPAVLTRPPQDGAETAEAAVPAGDEPVRQLRALRWGLVPSWAKDVKIGNRMINARAETVHEKPSYRRAFAKRRCLLPADGFYEWYTSEREGQKPVKQPFFIRPRDGAVMAMAGLYELWHSPQDEWLWTCTVITTQATDDVGRIHDRMPMVVPPGNWDAWLDPGLTAVEEVRGLLVPAMSGTMEAYPVSKAVNNVKNNGPELLQPLADGHIPGEHSGSGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VR41</accession>
    <name>A0A1H5VR41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89438">
        <property type="protein sequence ID" value="SEF89438"/>
        <property type="gene ID" value="SAMN04489712_102414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF89438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="177" mass="17728" checksum="35EAA0A79144CC38" modified="2017-01-18" version="1">MTAKPAMSSYTPSSMPSRRPSRGPSPGTSRGSSRGAAPGTSRGASPGPSRETSRQAEPDPNAGRGEAAPAAPMTTAEFATRIAERVRACPGVADLTAGPWGHVVTYRPGPPLQGVAVYDDEVRVSLVALADRPLTETAEAVGAAVAPLAGGRRVHVIVADVVADVAAGGRKPGNGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VRI5</accession>
    <name>A0A1H5VRI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89892">
        <property type="protein sequence ID" value="SEF89892"/>
        <property type="gene ID" value="SAMN04489712_102430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MEDS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="196"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF89892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="309" mass="34055" checksum="A7B717FD40E86EC2" modified="2017-01-18" version="1">MTPGTSLRHNALLYGDVGEYLAVTAPYLRAGLEAGDAVFAVVPRPRSQALRETLGRDGRDVTFIDAEVFYQHPVRALHEYDRVMRAHAPRRLRVVGENIWPGDRTETMEWVRYESLVNAVFAASGAQVICAYDRTAVDAEIIGHARRTHPWLIDGRAEYASGEYAEPAGLGTDSDRVPRTPPPSDAQYLPFGSEQELYQVRRFVAARASGHGLDGRRVVALETAVTEVATNALKHGAPPMGVRVWTRPGEFVCEVGDHGRWRPGAPAGLVPPGSALDSGFGLWTVRLLMDRVWLYAGRDGTFVRMVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VWN7</accession>
    <name>A0A1H5VWN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted PurR-regulated permease PerM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90977">
        <property type="protein sequence ID" value="SEF90977"/>
        <property type="gene ID" value="SAMN04489712_102468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF90977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="512" mass="53869" checksum="C36087C3EC4C4BA2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W176</accession>
    <name>A0A1H5W176_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate dehydrogenase (Quinone)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93274">
        <property type="protein sequence ID" value="SEF93274"/>
        <property type="gene ID" value="SAMN04489712_102553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="198"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="388"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF93274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="596" mass="64910" checksum="7259BAEEF5AC321E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WXJ5</accession>
    <name>A0A1H5WXJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, OmpR family, contains REC and winged-helix (WHTH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04349">
        <property type="protein sequence ID" value="SEG04349"/>
        <property type="gene ID" value="SAMN04489712_1039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG04349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="24039" checksum="EFF30703531529CB" modified="2017-01-18" version="1">MRVLIAEDERMLADSIAEGLRGEALAVDVVYDGDAALERLGVNDYDVLVLDRDLPVVHGDDVCRAVVESGAFVRVLMLTAAASVPARVQGLSLGADDYLVKPFAFEELVARVHALGRRSRPADPPLLERAGVRLDRARREVYRDGRYVPLTRKEFGVLAELLRAGGAVVSAEDLLEKVWDEHIDPFTNTVRVTLMKLRRKLGEPALIETVPGAGYRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X273</accession>
    <name>A0A1H5X273_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10361</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05944">
        <property type="protein sequence ID" value="SEG05944"/>
        <property type="gene ID" value="SAMN04489712_10361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG05944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="552" mass="56370" checksum="F742EFFBBDAAF06C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X2I1</accession>
    <name>A0A1H5X2I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05570">
        <property type="protein sequence ID" value="SEG05570"/>
        <property type="gene ID" value="SAMN04489712_10349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG05570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="503" mass="51826" checksum="3B9879027867749B" modified="2017-01-18" version="1">MPTPDEKDFMTEDVPGYRVLEKTGESGAGVVYRAHHERLGRQVALKVLSAGPMGEAAMARFRRECGVAGPPGGHPNVATVLEAGTAPSGRPYVAMEYFEHGALADRIGREGPLPVPEVLRIGVKTAGALAAAHEAGVLHLDVTPQSILMSRHGEPALAGFGVARLVGSSGMWHPQVPSPHHTAPEVLEGGQPSVASDVYSLGSTLYQLLAGTPAFQGPPGEGVDGLMSRVLHEPLPVIRRADVPAPVFEAIGTAMAKVPEQRFASATAFARRLRQLQSELGLPVTDPVEGPVHDPAEPPQAIPSTGGGAPSPPSAWGAPAERNDDAEPQPPETAAAGGPHSRTVAAVTVVLVGGLVGGIVVAGAFGGDGGGTFPQARASTARKNGTPSASPSARTLPPIPRAQILAAAPRLVRLASDQRTSVVLRWWLPAASRKLPILVRPAPWAGRPAITAGNGATGAAVRGLRPGAGYCFRVGAVLRGAATGRKPVIAWSKPLCIRGARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X3E3</accession>
    <name>A0A1H5X3E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA domain containing CoxE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05905">
        <property type="protein sequence ID" value="SEG05905"/>
        <property type="gene ID" value="SAMN04489712_10360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG05905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="386" mass="42244" checksum="A208BFCBE242292D" modified="2017-01-18" version="1">MNDDERLRRWRMVLGDGDGTGVRLEGNDVRMDAALEALYGQGSGDDRGSRGGRGRRGGLGESAPNVARWLGDIRSYFPSTVVQVMQKDAIERLDLTRLLLEPEMLKAVEPDVHLVGTLLSLNQVMPERVKDSARAVVRKVVRELESRLTQRTKSAVAGALDRSARVQRPRRPSDVDWHRTIRANLRHYLPDRRTVVPERLVGYGRRQQAVRRDVVLCIDQSGSMAASVVYASVFGAVLASMRALRTSLVVFDTAVVDLTDRSHDPVEVLFGTRLGGGTDINRAVAYCQGLITRPADSILILISDLYEGGLRDEMLRRVAALTTAGVQVVVLLALSDEGAPAYDHDNAAALAALGVPAFACTPDAFPDLMAAAIERRDLGDWAGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XD89</accession>
    <name>A0A1H5XD89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemE</name>
        <name evidence="13" type="ORF">SAMN04489712_103203</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09728">
        <property type="protein sequence ID" value="SEG09728"/>
        <property type="gene ID" value="SAMN04489712_103203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG09728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="353" mass="38128" checksum="05581D95331FEC4B" modified="2017-01-18" version="1">MASDTDPRTGSGPSQSAFLKACRRQPVPHTPVWFMRQAGRSLPEYLRVREGVPMLEACARPELIVEITLQPLRRYAVDAAIFFSDIVVPLKAIGVDLDIKPGVGPVVADPIRDRAGVAALRRLTPDDVPYVTEAVGALVGELGDTPLIGFAGGPFTLASYLIEGGPSKNHDHTKAMMYGEPGLWADLMGRLADITIDYLKVQVEAGAGAIQLFDSWVGAVGPDDYRESVLPHTRRIFEAIEPLGVPRIHFGVGTGELLGLMGEAGADVVGVDWRVPLDEAVRRVDPGKALQGNLDPAILFAPWEVVERRARDVLNRGRTAEGHIFNLGHGVLPTTDPDQLARLADLVHEVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XQC8</accession>
    <name>A0A1H5XQC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13904">
        <property type="protein sequence ID" value="SEG13904"/>
        <property type="gene ID" value="SAMN04489712_103359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG13904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="110" mass="11482" checksum="56B2827660414C00" modified="2017-01-18" version="1">MPCFRCGARQTDPARGASPWKRGVRADRQVLICPGCQGAHDWTAGLDRCAGCGSASLICRLGEVECRSCGHVREARPPERPGDLVTSGAPGLSEEVAAAIGRVLKRGPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XR46</accession>
    <name>A0A1H5XR46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13880">
        <property type="protein sequence ID" value="SEG13880"/>
        <property type="gene ID" value="SAMN04489712_103358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289725" evidence="1">
        <location>
            <begin position="21"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG13880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="39015" checksum="B4923AD60639F328" modified="2017-01-18" version="1">MKRILSLVLAAALAAGVAVAVLLDRAAGPPSRTQPVRGVIGSEKQAFFDDPAVRAAFARHGLRVQADPAGSRQIATSVDLGRYDFAFPGSSPAADRIRQRRQVTARYSPFSTPMAIATFEPIAALLRAEGVIGRAADGTWTFDVARYLDLARRRVRWDQLDDNAVYPVRKDVLVSTTDPRSSNSAAMYLAITSFVANGSAVVRDAEAEARVLPLMGRLFHDQGYTESTSEGPFEDYLSVGMGQAPLVCVYEAQFVGRAVQGQIKPGMLLAYPVPTVISRHTLVPLTPAGDRVGRLLTTDPQLQRLAARHGFRTADAAQFARVTAEHRVPVTANLVNVVDTPSYDALESLLRGIEKGYGDGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXF6</accession>
    <name>A0A1H5YXF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized membrane protein YckC, RDD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_104224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28470">
        <property type="protein sequence ID" value="SEG28470"/>
        <property type="gene ID" value="SAMN04489712_104224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG28470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="17545" checksum="08F20B3867FA9547" modified="2017-01-18" version="1">MPDDGALAEPGQRLVARVVDTLVVGLPVTLVARSEAVGLSPPTADLVTVPILAGLLLVYEWVQLALWGRTLGKRFAGIEVVAEPRRDGRGLGLGRALLRSATYALPIAARPVPFLGVAAGLFWVANAGLLLEGTRRQTLHDRLAGTLVVRRPQPEARPEVVPDGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YYV2</accession>
    <name>A0A1H5YYV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-hydroxybenzoate polyprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28615">
        <property type="protein sequence ID" value="SEG28615"/>
        <property type="gene ID" value="SAMN04489712_104230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG28615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="27217" checksum="A8AE34F083621CA2" modified="2017-01-18" version="1">MTTLKDLAELVRAPAALSVPGDTLAGGAQNLGPAVSSVCLYWAGMALNDYADRELDAKERPERPIPSGRVAPGQALALATGLTGAGLALAAVTGGRRRLAVALPLAAAVWAYDLKLKDTPAGPAAMAAARGLDVLLGGGPGAVPAAAALTVHTWGITTLSRGEVHGASPALLGGALAATTVATAVSALPAPGEGRAARIARLGLTAAYAGLVGRAQVRAARRGDAPSVRAAVGAGILGMLPLQAAFTARRGRLATAAALAAVHPAARALSRKVSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z3X3</accession>
    <name>A0A1H5Z3X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_104335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31031">
        <property type="protein sequence ID" value="SEG31031"/>
        <property type="gene ID" value="SAMN04489712_104335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="133"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG31031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="501" mass="52387" checksum="80876540C8BD774C" modified="2017-01-18" version="1">MILLVTLAVPLAGALLLLLPGARFLPGDAAVRRYGVAVSGVTLLLALVTAAVFDHGEPHRMQQGVDWAWAPAIDLRFHLGVDGVSLPLVVLTALLTFLCFVHMVRHPPSGGPARLLTALVLVLEVGMLGTFLALDLLLFFVFFEVVLIPMYVVIALWGGAGRRAAAYKFILYTLLGSGVLLVGLLLVAVNAGTLDMVALAERHGGGLSRGVQITAFVLIGLGLAVKVPMWPLHTWLPDAHTEAPTVGSVLLAGVLLKMGTYGFVRIALPVAPEGAQVWAPWLGLLAVIGIVYGALACLAQRDLKRLIAYSSVGHMGFVLLGIATLTPVGVNAALFGNIAHGLITGLLFFLAGAVKERYGTGDLAALGGGMLTSAPRLAAFLTFASVASLGLPGLAGFWGEMLALLGAYRPDGGLPRETFVTFMAVGALGAVLTAAYFLRLLARVTHGPVAEDRRDAVLPAPTSSEYAAWVPLVILTLLVGLWPKLLLDLTTAPVRTLLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z451</accession>
    <name>A0A1H5Z451_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31111">
        <property type="protein sequence ID" value="SEG31111"/>
        <property type="gene ID" value="SAMN04489712_104339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG31111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="92" mass="9740" checksum="0AAC8FA8B1891662" modified="2017-01-18" version="1">MVRTPLTEEQRDRGKALGQVLRAARGPRSAAAVAHEAGISLDTLRKIERGAIAAPAFFTVAALARVLDLDLGVLARTLMPDEQPGRQTPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZJ57</accession>
    <name>A0A1H5ZJ57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thymidine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_104556</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35687">
        <property type="protein sequence ID" value="SEG35687"/>
        <property type="gene ID" value="SAMN04489712_104556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="334"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG35687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="424" mass="43789" checksum="D011705235311896" modified="2017-01-18" version="1">MDAIDVIVTKREGGRLSPEQIDWVIDAYTRGEVAEEQMSALAMAILLNGMDRAEVARWTEAMIRSGERMDWSVLDRPTTDKHSTGGVGDKITLPLAPLVAACGAAVPQLSGRGLGHTGGTLDKLESISGWRASLSTGEMLRVLRDTGAVVCAAGGGLAPADRKLYALRDVTGTVESIPLIASSIMSKKIAEGTGALVLDVKVGSGAFMKTVEHARELAATMVAIGADHGVRTVALLTAMDRPLGRAVGNALEVAEAVQVLAGGGPPDVVELTLTLAREMLAAAGVDGKDPADALADGSAMDVWRRMISAQGGDPDAELPVARESHVVTAPATGVLTRLDAYGVGVAAWRLGAGRARKEDPVSFGAGALCHAAPGERVTAGQPLLTLYADDAARFPRALAALDGAVEIVPDGAPDLLPLVIDRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZVP5</accession>
    <name>A0A1H5ZVP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40044">
        <property type="protein sequence ID" value="SEG40044"/>
        <property type="gene ID" value="SAMN04489712_10512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG40044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="18031" checksum="C300F1A520914E69" modified="2017-01-18" version="1">MEPLADCYRTHAPLVRAYLRRLVPPQDIDDVAQVVFTEVWRFRHRYDPSRRLEPWLLAIARRRAVDHLRGRTPPTVPLEAAGDPLGHDGRADGDALADRDRVRRALAALPAPQRQAIELAYYGDLSQREIAERLHVPLGTVKARTTRGLRHLSTLLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZWM2</accession>
    <name>A0A1H5ZWM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subtilase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10553</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40849">
        <property type="protein sequence ID" value="SEG40849"/>
        <property type="gene ID" value="SAMN04489712_10553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292031" evidence="7">
        <location>
            <begin position="24"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="163"/>
            <end position="514"/>
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            <end position="140"/>
        </location>
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            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG40849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="569" mass="60022" checksum="BCF5198527BCC6B0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1B2</accession>
    <name>A0A1H6A1B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate lyase subunit beta / citryl-CoA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_105102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="SAMN04489712_105102"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
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        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
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        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG41835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="313" mass="34549" checksum="7A759F4ED7E0129C" modified="2017-01-18" version="1">MRSRRSTLAVPASNPRFIEKAQGLPADEIFLDLEDAVAPAAKEEARKNVVAALNEGDWGERVRVVRVNDLRTHWTYRDVIEVVEGAGADLDCVLLPKVQGPDDVRWLDRLLTQIETTMGYEVGRIGIEAQIEDARGMVGIDAIAASSPRLETLVFGPGDFMASINMRTLVVGEQPPGYTEGDAYHYILMRILMAARAHDLQAIDGPYFNVRDVDAFTRVARRSAALGFDGKWVLHPSQVEAANEVFSPAQEDYDHAELILDAYEYYTTVERRGAAMLGDEMIDEASRKMALVIAAKGRAAGLSRTRSFEPPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A4H9</accession>
    <name>A0A1H6A4H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pilus assembly protein CpaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="SEG43643"/>
        <property type="gene ID" value="SAMN04489712_105209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_dom"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG43643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="518" mass="55116" checksum="B109709A4DAAF729" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A7F0</accession>
    <name>A0A1H6A7F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44673">
        <property type="protein sequence ID" value="SEG44673"/>
        <property type="gene ID" value="SAMN04489712_105264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="16960" checksum="213BA3CE287593A1" modified="2017-01-18" version="1">MTLGELIAALEAADPTKVAPNGFANPHSYRGYYEDLAFEPARNITIGAMLAAARSAVGTTYQGWKGGDYTMTADTDVWLADEGYCGETLGPTLLRLILEGAQDAPSLRDRLREALTRPLPCPRCGSTRPCRCYVEATEKTDARLDALMAVLDEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AG57</accession>
    <name>A0A1H6AG57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_105416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47352">
        <property type="protein sequence ID" value="SEG47352"/>
        <property type="gene ID" value="SAMN04489712_105416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG47352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="19699" checksum="F8D8032D0EADEF1F" modified="2017-01-18" version="1">MDDDGVTYEEFVTTRAQTLLRYGYVLTGNPHDAADLLQESLVRLRAAWPRVVNKRDPEGYTRTIMARQHISIWRRRRRESLVGEVPDGQYIEPGLDRAEHDPRLWELLSALPRRQRAVLVLRYYEDMSDAEISATLGISRGTVRSQAARALDKLRTGWHPAAERAESRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AW79</accession>
    <name>A0A1H6AW79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52305">
        <property type="protein sequence ID" value="SEG52305"/>
        <property type="gene ID" value="SAMN04489712_10621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG52305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="124" mass="12673" checksum="C60250945B4F56D7" modified="2017-01-18" version="1">MHIALWIIAGLLAAAFLAAGLMKLAQPRERLVASGMGWAGDFPDGMIKAIGALEVLAAIGLILPAALGIAPVLVPLAALGLVVLMIGAAIVHARRKEFPMIGANVVLLALAAVVAWGRFGPHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJC7</accession>
    <name>A0A1H6BJC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60803">
        <property type="protein sequence ID" value="SEG60803"/>
        <property type="gene ID" value="SAMN04489712_107158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG60803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="27703" checksum="1458034E677FF297" modified="2017-01-18" version="1">MAATLGVVGHSLLHQVLVSDLVLPLALAESTGTQSLTGHGIRLNGGTWLRADLLVCRDEQAAGGRRYVEGAPLLAVEVVSPASRGRDLGAKKDAYQRFGVPHYWVVDPTGAELRVHVYELADGGYAERAVVVPGDRRQLTEPFRLELAPASIFDRTSRWAGRRRGRNMEYIGPDLPSCEEPILVDAFGHRWPTGAEKVELEDGCPIFYGEWDERDVAIAERTYPGRVVRLDQPPGEPGTITILPGPEPAARPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BL25</accession>
    <name>A0A1H6BL25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N,N'-diacetylchitobiose transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_107204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61332">
        <property type="protein sequence ID" value="SEG61332"/>
        <property type="gene ID" value="SAMN04489712_107204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG61332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="323" mass="35419" checksum="739AA8AE9046FF09" modified="2017-01-18" version="1">MLDTAPAVGAAPDRRSSGPARPRRRPRPGPYLLIAPTLLVIATLMFWPMVQIAIMSFQKVGNRQLAGEPAEQVGTENFSTILSDDLFWQSLRHTVLFAVVAVSLTLLLGTLVGLLLHRLGRRMSAFVAAGVMVAWATPPITAAIIFYWLFGSTGGVVNWFLDLLPDVLVGGDWIDHNWFATPLRTYTVLTVCVVWQSFPFVAVSVLAGLKSLPGELLEAARVDGASAWRSFWQITFPLLRPIFLVLLVLSIIWDFKVFTQLFIMSGMANRDAFNLSLYAYSEAFGGMNAKLGMGSAIATVLTLLLLAVTAVYVRIMVRQGETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BQ91</accession>
    <name>A0A1H6BQ91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62871">
        <property type="protein sequence ID" value="SEG62871"/>
        <property type="gene ID" value="SAMN04489712_107328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG62871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="39" mass="4178" checksum="39BE0EB36A11F763" modified="2017-01-18" version="1" fragment="single">MTADDVRVLITDDHPMFRQGLHGLLEALGIDVVGQAESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BW13</accession>
    <name>A0A1H6BW13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64898">
        <property type="protein sequence ID" value="SEG64898"/>
        <property type="gene ID" value="SAMN04489712_10862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG64898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="18656" checksum="DCEFC2D3C0D94744" modified="2017-01-18" version="1">MTRNGEEPTLDERVARLETRVAELESGHRSSRAGGPDLGADAFWALTGLKERADAPGMVLFTGSVTLPGGEQAEWQQGHPVDELLADDWSQAAAAVAALGHPIRLLLLREILHGARTVAELGAHERLGTTGQLYHHLRQLVAAGWLRTTARGQYAVPAERVVPLLVVLAAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BX63</accession>
    <name>A0A1H6BX63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine phosphatase RsbU, regulator of sigma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65047">
        <property type="protein sequence ID" value="SEG65047"/>
        <property type="gene ID" value="SAMN04489712_10873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG65047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="528" mass="56601" checksum="E280EBB218E75D27" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZG6</accession>
    <name>A0A1H6BZG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66078">
        <property type="protein sequence ID" value="SEG66078"/>
        <property type="gene ID" value="SAMN04489712_108162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="30977" checksum="AADDB70F1B70B175" modified="2017-01-18" version="1">MAAEITTWDVPAGDHTLRVSTTGDPSLPALLFLHGSGPGVTGLSNWERLIGDLGDRYYCIAPDTLGFGDSDHPNPPPRGMAAFTELRIAATWAMLDELGVRKVSLVGNSYGGQMSIAMTLERPERIDKVILMGSGGMPGLQPLPGLAKLINFYDDPTEEAMAELLALFVHDPASFGDRLHEIAAIRVPRATREEVRRSHLATFDFTAGPRVGWGPEELAKIRQDTLVIAAREDQIVPVDSSLYLSRHIPNARLHIVPNCGHWSQIEYPELFARMVDGFVRGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C0L1</accession>
    <name>A0A1H6C0L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66509">
        <property type="protein sequence ID" value="SEG66509"/>
        <property type="gene ID" value="SAMN04489712_108199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG66509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="15027" checksum="19152BA37880D410" modified="2017-01-18" version="1">MGDAMLFTISLGITLLGLVVSYGVAKRRGAASGLRGAAWSMVPLAATLTGVTGFVADLVFSPAKWAGVALAGLAVLLYLVSGVMLSRRGDGDGGGRPQVGGAGTAGRAGRKERGERRPQRAVEPSAGPSADPDLAEIEEILRRRGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CA43</accession>
    <name>A0A1H6CA43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69763">
        <property type="protein sequence ID" value="SEG69763"/>
        <property type="gene ID" value="SAMN04489712_109113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="17438" checksum="3D439DF878C00925" modified="2017-01-18" version="1">MAVLALGVAGCSDAGDRGDGQAAATQAPSSVPAVPPGPPVCDPPSPVRASSFSSGLPEVQGTGRGAQLWGMVMMRHPYPPFPVGDTAEEEVKIVWRMTGKGPLRMALTGPDGKARRLAWGPESHSGSTYERPGDEWGTGFRFTEPGCWHLRATRDDVAADVWLKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAQ6</accession>
    <name>A0A1H6CAQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-coenzyme A thioesterase PaaI, contains HGG motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69847">
        <property type="protein sequence ID" value="SEG69847"/>
        <property type="gene ID" value="SAMN04489712_109120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="88"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG69847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="182" mass="18938" checksum="DED866D03CE1EC28" modified="2017-01-18" version="1">MTSPSEPRAARRSSAASPLTTPPSDAAVPVVDASAVRDMEDVGEVLGNACFGCGPDVPHGLRIRRTGHDGSTAYAEFTVQPEHQGAPGLAHGGILASAMDEILGTSAWLLGGRYVTGRLETDYLAPVPVGSVVHLTARCTGVDGRKAYIEGEARLGGPDGPIAVRAASIFIKVPLEHFTKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDK8</accession>
    <name>A0A1H6CDK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-formylglutathione hydrolase FrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71071">
        <property type="protein sequence ID" value="SEG71071"/>
        <property type="gene ID" value="SAMN04489712_109238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294724" evidence="1">
        <location>
            <begin position="44"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="357" mass="39034" checksum="FD60E7173A3183F3" modified="2017-01-18" version="1">MTISHGVRSHGVRSHGVRRTLGALGAAVLGLGLLPGLPASAWAAAAYRPADNGARIVGQRQVDASRLEITVRSPAVGRDLKATVLVPKGWRRNAKRTWPTVYMYGGGGGDDHTTWIKQTGLAALARKWDTLVVLPYAGSFGGYVNHFNYGRRGKPRWETHHTVELTQLVERNLRAGSRRAVMGISAGALGAMTYAGHKPGLFKYVAAFSGVLHISRPGVPAILMAINARSNQGDPFNIWGVPGVHEANWKAHDPYELAPRLRGTKLYISSGTTGERGPLDPKNLSEEEATRLRILGGLSEQLTGEASKSFTTRLRQLKIPVTTHFYGNGWHAWPYWNREMRRAWPTAMKTIGAKQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLX1</accession>
    <name>A0A1H6CLX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NitT/TauT family transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_110178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73994">
        <property type="protein sequence ID" value="SEG73994"/>
        <property type="gene ID" value="SAMN04489712_110178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="29"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG73994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="30389" checksum="3526C350EE08054D" modified="2017-01-18" version="1">MSLLRQRRPVVGTGSGRLLDQEPADAAGVRLREVSKTFSRRRRPGRTALDGVSLDVEPGEFLCLLGPSGCGKSTLLNILAGFVPADSGEVLVGGRPVTGPGPDRGVLFQTPMLFSWLTTWQNVLYGPKARGTLTPQVHEEAERLLETVGLADARDAYPHELSGGMRHRAAFARVLINRPGVLLMDEPFGALDAITRAAMQRFLLELWQQQRMTIVFVTHDVEEATLLGDRVCVLSGPPGGTKAVIDIDLRRPRSYDDTETLEFVNAKRRIREVLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQJ5</accession>
    <name>A0A1H6CQJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75271">
        <property type="protein sequence ID" value="SEG75271"/>
        <property type="gene ID" value="SAMN04489712_1118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="220" mass="24470" checksum="EE371FDD14E471A9" modified="2017-01-18" version="1">MAGRITPAAGRYGGRSAAERQAERRRRFLEAGLDLFGAGPGYRATKITDVCRAAGLSTRQFYEEFRTLEDLLAELHLYVNDVAAQAVVDLLPQVQHLDPIDRYTRLFRAYAAGVTADPRHTRIAFVEIIGVSPRLDRQRLDRRARWIDFLCEQAEAAAARGEIPARDFRVPAAAFIGAINGLMHDWAVGWVDATLDQIIDELLQILLGRLQFAAGEGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT75</accession>
    <name>A0A1H6CT75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76200">
        <property type="protein sequence ID" value="SEG76200"/>
        <property type="gene ID" value="SAMN04489712_111135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295187" evidence="2">
        <location>
            <begin position="26"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="324" mass="33626" checksum="23BEEEC6864F46BF" modified="2017-01-18" version="1">MTTAAALAAGLTLTAAALAPVPAAAHGAPAAPGADDLTWAVRPSGPTGPSGRDYFVYTASPGQTIKDKVSISNLSGRTLTFRVYATDAFNTADGAFTLLTADRAPTGIGTWLKFGGGFHSVKAGKTVQVPFTLTVPHDATPGDHGGGIIASITQQQTTARGQRVNVDRRVAARVYLRAQGPVTPSLQISELRTGYSAPVLGGGRMKVTYTVRNTGNIRVTALARIGVQGPFGVPLGGRASRRIPELLPGNSYTFTEQVGGIAPAGRLTASVRLSLTDPQNGTPLAARPVARRSSLWNVPWLPISVVLVIAAALVVRRRRPGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CWS6</accession>
    <name>A0A1H6CWS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76856">
        <property type="protein sequence ID" value="SEG76856"/>
        <property type="gene ID" value="SAMN04489712_111216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="157" mass="17939" checksum="E61885FD5315A592" modified="2017-01-18" version="1">MLDGMSEPRWLDAGQQRDWRAFVDGSLRLHDLMDRDLKSKHGLSESEYEILVRLSEAPGHSLRMAELADHASQSRSRLSHTCTRLETKGLVRRESCPNDKRGVFAHLTDEGFAALERAARDHVETVRDFFIDVIDPEDLQAIGRAFRAVNERIAEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1B1</accession>
    <name>A0A1H6D1B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78987">
        <property type="protein sequence ID" value="SEG78987"/>
        <property type="gene ID" value="SAMN04489712_112150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="364" mass="39956" checksum="3A793A294F3C5DD3" modified="2017-01-18" version="1">MTAPHGVGGVRLSRELWGAVLHALHSDSLAVRERVAASVEAIGPRPWRADLRKPGLPARRLVDIGLPSTEPQPDWIKPGHASPVRPPARPGPRRKRPSMNPRKLIDTDGTRPHPARVWNHWLGGKDGHPVDREVGDAIADAFPEIAYVAMQGRAFLCRAVRHLAGQEGVRQFLDIGAGLPTADNTHEVTQRVAPGSRVVYVDNDPLVLAHARALLAGGERYAADYVEADLRDPGRILAEAARTLDFSRPVAVMLLSVLPHIADDEEATSIVRRLMEAVPSGSFLVLSHETTDAPGGYRFQKTVKLFEEQGGPAWVTCDRDQVARFAEGLELVEPGVVWTSYWWPDPAPWEPTPVHQYALVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1D1</accession>
    <name>A0A1H6D1D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79027">
        <property type="protein sequence ID" value="SEG79027"/>
        <property type="gene ID" value="SAMN04489712_112156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025355">
        <property type="entry name" value="DUF4259"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14078">
        <property type="entry name" value="DUF4259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="14992" checksum="A5BA5D9F01BBC104" modified="2017-01-18" version="1">MGTWGPGPFDDDTAMDFVDYLLDLPPDQVQQELRTAVRLACDVGGYLGYVDAVRAVAAASLLAGVVPPGYESSWTVPLRLTPDLAAEAMEAIGRAHSAGSDLHELRAESGTYARVDEALRPVLAALQRGAHPVDLGQESLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1K2</accession>
    <name>A0A1H6D1K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78898">
        <property type="protein sequence ID" value="SEG78898"/>
        <property type="gene ID" value="SAMN04489712_112139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="93" mass="9702" checksum="9FF134A9409D47DB" modified="2017-01-18" version="1">MALRPVAHTRGELAAFLGCDHEAAAHFTRVATIADRGNAPRWAAEARSRTAAWPSVSSVQQTVERAAASAMAVPPGSADTVPPGSADPGERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D620</accession>
    <name>A0A1H6D620_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80847">
        <property type="protein sequence ID" value="SEG80847"/>
        <property type="gene ID" value="SAMN04489712_113163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="32086" checksum="16A15D3F41AD4B9A" modified="2017-01-18" version="1">MCRLFGMTTGGPRVEASFWLLDAPYSLKEQSRRMPHGVGLGWFSLGDEPVRDRAPLAAFENIDFARGARHIVSHTFVSHIRYASTGEVNVHNCHPFDMHDRLFAHNGVVKGLDILEGWLTDVDKALIKGQTDSEMVFAYITAEIRRHGDTTTGLIEAIRRIGAELPLYSVNLLLAEAHRIWALRYPESNELWVLPPKEGGGPGETRHLVSPHEPGAVDLTSLGHSAPAYVVASEPMDDDPAWRLMEPGELLIIDGLKEESRFPFDPPRFQLTHKEMSAKEVASQEHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8E1</accession>
    <name>A0A1H6D8E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_114118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81687">
        <property type="protein sequence ID" value="SEG81687"/>
        <property type="gene ID" value="SAMN04489712_114118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="77"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG81687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="545" mass="55760" checksum="70920F59F16713F1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9K4</accession>
    <name>A0A1H6D9K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_114178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81950">
        <property type="protein sequence ID" value="SEG81950"/>
        <property type="gene ID" value="SAMN04489712_114178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="920" mass="96375" checksum="015E4AB9172D51F6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9N4</accession>
    <name>A0A1H6D9N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81814">
        <property type="protein sequence ID" value="SEG81814"/>
        <property type="gene ID" value="SAMN04489712_114150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="43" mass="4493" checksum="248921C460997CFA" modified="2017-01-18" version="1">MNATTPGTARVGYARCSTDEQDVVIQTEQLLALGVPADAADQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DA88</accession>
    <name>A0A1H6DA88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81605">
        <property type="protein sequence ID" value="SEG81605"/>
        <property type="gene ID" value="SAMN04489712_11494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG81605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="474" mass="51739" checksum="1FFD7562ADC25337" modified="2017-01-18" version="1">MPNHWTRSELDLHLRLSAGRGKRAGLEQALRDAVRDGRLSSGAPLPSSRALARDLGIARGTVTQAYEQLVAEGYLTSRPRSGVRVAPQPTPPQAEDTAPPVPASLPPVRGADLRPGLPDLSAFPRRPWLAATRHVLQTAPNTAFGYGDPTGCLELRQALAEYLGRSRGVVATPDRVIVCAGYSHAIRLISRTLRRRGATAVAFEDPSEPWFPLLAEECGLTVGYAPVDRDGLVVDALTDEAAVTVTPAHQYPLGMTLGPARRTRLLTWARRHESFVVEDDYDGEFRYDRQPVGALQQLAPDRVIYAGTASKTMAPGLRIAWIVLPADLVAPLRDTIRAEEGHVSVIDQLVLAHLIRTGELDRHLRRCRSRYRRRRDRLQEAVAGHLPHARLTGIAAGLHAVLELPGDPAQEPRLLGHLAANEVAVDGLSSFHHRRDDHPLGIVIGYGSPPDHAYGNALDTLIDALRHHRAPGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAT4</accession>
    <name>A0A1H6DAT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate phosphate dikinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82577">
        <property type="protein sequence ID" value="SEG82577"/>
        <property type="gene ID" value="SAMN04489712_11546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="293"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="407"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="538" mass="56056" checksum="2152419AACA95C0C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAV7</accession>
    <name>A0A1H6DAV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81855">
        <property type="protein sequence ID" value="SEG81855"/>
        <property type="gene ID" value="SAMN04489712_114159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="71" mass="7398" checksum="1F75011D618256BF" modified="2017-01-18" version="1">MDERKQMQALITGGGIGGLTTAIALHRSGWRVRVLEQAAEFTEVGAGLSIQPNALRTLDALGLATRSAPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DD05</accession>
    <name>A0A1H6DD05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82673">
        <property type="protein sequence ID" value="SEG82673"/>
        <property type="gene ID" value="SAMN04489712_11561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="179"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="240"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG82673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="471" mass="50966" checksum="ADA4077300D645C6" modified="2017-01-18" version="1">MNNQRRWSITTRITLFAGTVAALLFVLMVVIVMTGAYRFATAERRDEVIAAGGRVAHQVEHHQLAAPLAEQKDRNVQVVDPAGVVVASTPQLKGKPPMADFDPDGRNMRTGVVCGGVFPSGECNIVVAQSAHREGQDWTVYSASPAVPRYVTPWLAGTVVGGAALMALAITGLGHRIVTTSLKPVTAIRAELDRISETGADRRVPLPPSLDEIHDLAGSVNRTLARLQAAMRQQCHFTSDASHELRTPIAAIRAEVEDALYAPEDTSVPTLGNAVLSSVDRLEAIVDDLLTIARLEVNRPAGGEPIALAEFVTAEREKRQNSAKRFEYALEPGVVVNGDRTLLSRLLTSLTDNAERHAASTVAVRLRRAPGPQWDAQRFPHGIALLEVIDDGPGIDPDKREVVFQRFARLDTARDRGTGGTGLGLAIARQIAEAYDGSLRIEDSPRGARFVLRLPLHPIPDDVPNENRGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJW9</accession>
    <name>A0A1H6DJW9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="11" type="ORF">SAMN04489712_117100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84956">
        <property type="protein sequence ID" value="SEG84956"/>
        <property type="gene ID" value="SAMN04489712_117100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="258"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG84956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="550" mass="57970" checksum="3F77420755E1C591" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL38</accession>
    <name>A0A1H6DL38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85851">
        <property type="protein sequence ID" value="SEG85851"/>
        <property type="gene ID" value="SAMN04489712_11892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="160" mass="18445" checksum="613B94312C620658" modified="2017-01-18" version="1">MTRWLDDDEQQTWRAFLWTSRLLNESLDRQLQRDSGMPHTYYVILAMLSEAPGRRLTMTELARVVRSSPSRLSHAVTRLEKEGWVRRVPHPTDRRTTMAELSDEGFTTLVEAAPGHVEAVRRHLFDPLTREQVLQLREILRAVLPALDTEDEAADIFGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLP0</accession>
    <name>A0A1H6DLP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_118140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86051">
        <property type="protein sequence ID" value="SEG86051"/>
        <property type="gene ID" value="SAMN04489712_118140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="245" mass="27961" checksum="56B8EB0706F6D224" modified="2017-01-18" version="1" fragment="single">GLAASSGRLITYLDGDDWIAPGYLAAAVEAIDAIGCDFIKTDHIRVYGRRREIHRAPQGVRGVALKPRDGILPVLDMTMVDYPNAWSGVYRRELADDGLLTFDEHLHTCEDRPWTWRLLRHASSYAVVSLFGVFYRREVAGSLTKIGDERQLHFFDAFDKVIAELQDDPEQDRFRPKALYNYCDLIAWHLKHEERLTPDLQQVQRLRARATLRGMDREQLVSVLPALGRQRSLMLTELVGMEAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMP4</accession>
    <name>A0A1H6DMP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Decaprenyl-phosphate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_119101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86518">
        <property type="protein sequence ID" value="SEG86518"/>
        <property type="gene ID" value="SAMN04489712_119101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG86518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="281" mass="30253" checksum="0B903FED57B65EC0" modified="2017-01-18" version="1">MPLRDLLRSARPRQWIKNILLIAPSLTSGVLPEPRPAARLVVAFVAFSLTASGVYFINDVRDADHDREHPTKRLRPVAARALTPRLAIAVGALLVATGLLLGLSIRLGSVIGVYAAVSLAYCFLLRNLVVTDLLAVASGFPLRVIAGGQATGATVSFWLLVTTCAGSLFVVTGKRYSEAVVFGAAKVRIRPSLSRYRVVHLRLAWLCSVAVAMTAYAIWAFGEGNAFSAMSLIPFALALLRYMEAINGARAAYPEDLVQKDRTLQALGMTWLGIFAARGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMZ1</accession>
    <name>A0A1H6DMZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86531">
        <property type="protein sequence ID" value="SEG86531"/>
        <property type="gene ID" value="SAMN04489712_119104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296063" evidence="1">
        <location>
            <begin position="27"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="32146" checksum="758387F6ADB49D1A" modified="2017-01-18" version="1">MTAAAWSLCLALVLAGLSRINWPVQAVSPDGRRYLTAGSGRPVSLPFMLRWLLPRLCGDSLRRWRWCTTAHLVALPPLVTVWMAPWVADDRLRVIGGLLLCGMPGIWRIQLRWPVLVDGTAMAWALGSAICFQHGLWVPGIAAVLVSGCVKETAPVFAACFAWHWVALVGLAAPLVRRLTGTIGEDLFGQPDLLKDPWRAGSLYHAGKWFDPLAMLTPWGAGLLAALSVDTRIAPMLIVTVALAYAQLLIATDTARLYQWAAPPVVLGAVQVMPSRWAIAILIVHLCNPWAGSAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP57</accession>
    <name>A0A1H6DP57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Magnesium chelatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87004">
        <property type="protein sequence ID" value="SEG87004"/>
        <property type="gene ID" value="SAMN04489712_12050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="2">
        <location>
            <begin position="301"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="519" mass="54738" checksum="7C3BB7B901DC2DA6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPB4</accession>
    <name>A0A1H6DPB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="6" type="ORF">SAMN04489712_12071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87120">
        <property type="protein sequence ID" value="SEG87120"/>
        <property type="gene ID" value="SAMN04489712_12071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG87120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="58" mass="6633" checksum="ECC13D7853634A19" modified="2017-01-18" version="1">MAVPKRKKSRSNTRHRRSQWKATAPNLVACPTCREPKISHLACENCGTYNRRQVIPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPM6</accession>
    <name>A0A1H6DPM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87218">
        <property type="protein sequence ID" value="SEG87218"/>
        <property type="gene ID" value="SAMN04489712_12089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="214" mass="23656" checksum="66C2A368075A775E" modified="2017-01-18" version="1">MADRELKLNSLGRYSKESPLYILEEHGHCEVPAGCGGVVLRWRNPQAGVPFTMWLYTGGTCELRLDGAVPPSSRPLVPFGEHVLTFTMTEVDPAFMVLMFAAGHRPDAARDLRRSAPEASEVTLVSEAEGSWRYTFTEPDGDAWMFPGFDDSGWSPMVRQEDRLPLPEGQTWDPASYKLNRLAGFGATGLGVQGRGERVWIRKVFTIPGPGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPS1</accession>
    <name>A0A1H6DPS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_119135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86646">
        <property type="protein sequence ID" value="SEG86646"/>
        <property type="gene ID" value="SAMN04489712_119135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7588" checksum="AFB40B19930C43F7" modified="2017-01-18" version="1">MAEGEAEVSEVTTQPGDAIGRELLPLFGITDPADETEFFEQMVRDRRLVIRLRVTHLYGTALDGPVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPZ8</accession>
    <name>A0A1H6DPZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_119132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86635">
        <property type="protein sequence ID" value="SEG86635"/>
        <property type="gene ID" value="SAMN04489712_119132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG86635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="390" mass="43186" checksum="99ADAB606D9A8FC1" modified="2017-01-18" version="1">MLFPVPGRIRDLRDAVHAFMTERVEPAEPVLNAGGVEARELFERLRKEAKAEGLWALGHPAELGGGGLPFLDYVYVNEVQGRSEWGQLVLGTFTLQDSIMLHKYASPRWRERYLAPMVAGEVSPSFAMTEPDVAGSDPTGLRTTAVLDGDEWVINGRKWFTTGAAAAAYTTVMCRTEPDDAPPHKAFSMIIVPTDTPGYRIVRETPVLGIHGGHYEVDYDDVRVPADNLLGPRGHGFVIAQDRLGPGRIFHCMRWLGQAQRAFELMCARLEQRTAFGEKLGAKQLMQQHVFDSYAEIQAARMLTLQAAERIDAGDQARVEIATIKVVGARMVHNVIDRAIQVHGAAGLTDDLPLSRMYRHAREARLYDGPDEVHIQSTAKRILRRVGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQM0</accession>
    <name>A0A1H6DQM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="6" type="ORF">SAMN04489712_12044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86976">
        <property type="protein sequence ID" value="SEG86976"/>
        <property type="gene ID" value="SAMN04489712_12044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG86976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="20807" checksum="CEA967F6656E8E9D" modified="2017-01-18" version="1">MIDEILFEAEEKMEKAVAVAKEDFAGIRTGRVTPAMFNKITAEYYGTPTPINQLASFTLPEPRMVIVQVFDKSSMNAVEKAIRDSDLGVNPTNDGNVIRVVFPDLSEERRREFIKIAGGKAEDSRVSIRNIRRRAKDALDKLAKDGEAGEDEVRRAEKELDDATHKHVAQIDELLEHKKAELLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DR28</accession>
    <name>A0A1H6DR28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87857">
        <property type="protein sequence ID" value="SEG87857"/>
        <property type="gene ID" value="SAMN04489712_12119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="56" mass="6353" checksum="C50723C75ED3F45D" modified="2017-01-18" version="1">MLRRFTCGGPKRPAYQAIEELGRVIGPVLDHLNLYGRFELDMARHLDLGQEPSSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT29</accession>
    <name>A0A1H6DT29_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpC</name>
        <name evidence="13" type="ORF">SAMN04489712_12131</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87903">
        <property type="protein sequence ID" value="SEG87903"/>
        <property type="gene ID" value="SAMN04489712_12131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="73"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG87903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="31616" checksum="F8EB9AB32350A1DD" modified="2017-01-18" version="1">MRMPSWIRQHLAAVRALLVFTVVCGIAYPLAVWAVAQVPGLNDRANGSIVKTADGRTAGSALIGQAFTDNNGDPLRQYFQSRPSAAGDGYDPTSTSASNLGPEDILDTLPVPGAKDEEDNPDEGRQSLLTQVCERSKAVGELEGVSGARPYCTPDGVGAVLKVFGARAADGSVPKPTRVVSANQGCPAQPFLGTYLGVRVECAKPGEDLAAGLTVPIRGNAPATPKVPADAVTASGSGLDPHISPEYARLQAPRVAKARGVPVAQVLAAIKHNETGRALGFMGEPAVNVLRLNLALDKTHPYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU30</accession>
    <name>A0A1H6DU30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88760">
        <property type="protein sequence ID" value="SEG88760"/>
        <property type="gene ID" value="SAMN04489712_12274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="131"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="277" mass="30739" checksum="25E4331C3F5E8DDF" modified="2017-01-18" version="1">MRVYGMAWVGSRTPRFESMRDFLADVVGLPVGLDQPDAVVFDLPDGDAFEVFKPTDTEHSFFDHPVAGLLVDDVREARAELQAHGIEFIGDVHVGVETSWATEWSHFRAPDGHVYVLVSRPAAHPGGSRRAFDELRICLRVRDLDAAVRVYRDGLGLPIVDEWTHPGGQRGVLFAVAPAAIELFDEAQWDLVDDSETGSRHGRDHALRVEVRDEAELRALAARLAGAGAPAAGELVDTPWEQRCLRVAAPEGEQLTLFVLPDEERRVRESARRLLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX59</accession>
    <name>A0A1H6DX59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89293">
        <property type="protein sequence ID" value="SEG89293"/>
        <property type="gene ID" value="SAMN04489712_12360"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
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        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="153"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="488"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="754"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG89293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="832" mass="91968" checksum="B29DFE7F371073AA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXH6</accession>
    <name>A0A1H6DXH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89413">
        <property type="protein sequence ID" value="SEG89413"/>
        <property type="gene ID" value="SAMN04489712_12387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="30205" checksum="B5090DB3D9EDF1F7" modified="2017-01-18" version="1">MTARLAQRNGFGAVWASGFSLATSHAVPDASVLSMSESLAAVRMMRAATDLPIIADCDTGFEDTADITSLVQSYEAAGVSAVCIEDKAFPKYNSFLSAPQTLETTSVFSAKIEAAKKAQRGTGFMVAARTEAFIAGLGARQAIARAEAYVNAGADMILVHSKASSPHEIYEFMELWDHRSPVAVIPTSYHGVTIDELGSAGIAMVIYAHHAMRAAARAVNMALRSIIDAGTTTHIEKDLATLQEVFEIQGATGLRGSRSAGGEAGSRTRNASKNFISPGDGTGRDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXR6</accession>
    <name>A0A1H6DXR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetolactate synthase-1/2/3 large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90127">
        <property type="protein sequence ID" value="SEG90127"/>
        <property type="gene ID" value="SAMN04489712_12546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="198"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="381"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG90127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="534" mass="54803" checksum="23BE78862D1817BB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY44</accession>
    <name>A0A1H6DY44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90089">
        <property type="protein sequence ID" value="SEG90089"/>
        <property type="gene ID" value="SAMN04489712_12535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_33" evidence="1">
        <location>
            <begin position="96"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="28590" checksum="73F56476FDEC99C8" modified="2017-01-18" version="1">MREDDGRRLDHRTLEKLRFRAMRWVEEGVRPPEVAERLGLRRSTVYGWLAAYREGGAEALRARPVPGRPPKLAWEQVREVLVRLAGQGPREVGLDGELWTRPVLCALLRRDLGVQIAPVTLTRMLERAGLTAARPLGTAGLPPALARWRARQLPSLRESVRAEGGTLYFLAHAAEEPAPDGPGRVRLGMVSAAPGKGATRFLLVGGEVSGPDVAGFCARLVLDTRGPAAVVLDGRAPHRTDLLAALAAGTGGALRPVYLPQVTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYX1</accession>
    <name>A0A1H6DYX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90537">
        <property type="protein sequence ID" value="SEG90537"/>
        <property type="gene ID" value="SAMN04489712_12666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="113"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="219"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG90537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="42505" checksum="0E8957835A59B82F" modified="2017-01-18" version="1">MREFLAAELPADWRGVGALDAEAADAFAERWRVTLFEHGFLAPSWPSEYGGAGLTPLEQVVLAEEFARVGVPTGIQNDVFSIVMIGNTLLHWGTEEQKQHFLPRILSGEDRWCQGYSEPGAGSDLAGLSTRAELDGDEWIINGQKIWTSSGHLANWIFVLARTDPDAPAHSGISLLLVPMDQPGVEVRPIRNMSGDSDFNEVFFTDARCPRENVVGEVNGGWKVAMTLLGYERGEAAATLPIMFRTELDRLFALARENGAAEDPVLRDRLADAYVGVEVMRFLGMSSLARFLEGHPPGPDAAVSKLYWSEYHQKVTELALDVLDVESLVVQGRRPTNVTMFQTDDVGAPNDSASWITTAMISRSGTIYAGTSEIQKTIIGEKLLGLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ04</accession>
    <name>A0A1H6DZ04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90572">
        <property type="protein sequence ID" value="SEG90572"/>
        <property type="gene ID" value="SAMN04489712_12675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG90572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="223" mass="24560" checksum="035B8D7746151396" modified="2017-01-18" version="1">MRLFAERGYAATGIREIGRAAGLNSATLYHYAGGKEDLLTGIMRAGLQELLRVGREAVEHSADPAVQLARLVLGHVATEALNPLTSRVIDREVQALTGDNRAEIMALRDDYESLFQRVLERGVRTGEFQVTDVQITRLALLEMCNGVAIWYRGDGRLSVADLQDRFVEFGCRLVASRPVPHEERGPEIHVERLASEPPQHNAPGTAPQPANPAGAADRREFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E036</accession>
    <name>A0A1H6E036_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty-acyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90564">
        <property type="protein sequence ID" value="SEG90564"/>
        <property type="gene ID" value="SAMN04489712_12673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="438"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="530" mass="57430" checksum="C0ABFAD0D8431E18" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0G6</accession>
    <name>A0A1H6E0G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91017">
        <property type="protein sequence ID" value="SEG91017"/>
        <property type="gene ID" value="SAMN04489712_12815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="101" mass="11193" checksum="EC1CE5032552CC5B" modified="2017-01-18" version="1">MVTPHLERLAEELADDGWRSLPYYEHDPAYLRVWHPDLDCFGLSVGVLPFLATAAGEAVWWYVLLPHVRLAPCDDVPGAVGQIALLLGPWAMAARSQEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0U0</accession>
    <name>A0A1H6E0U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90773">
        <property type="protein sequence ID" value="SEG90773"/>
        <property type="gene ID" value="SAMN04489712_12734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="334" mass="36511" checksum="19B19DAAB51FF843" modified="2017-01-18" version="1">MATSELVPQPARYAVFVDAGYLYAASGALLLEASSRREYRVAAEKLIRALTGHAAEGLRGELLRVYWFDAAPRRQPTVDQRVIANLPLVKLRLGNLNAQGQQKGVDAQLRADLEALARHRAITDAVLLAGDEDMLPAVEAAQRYGVRVHLWGVEPTHGSNQAEWLVWESDTVEVLSADFLRPYFTKAKVLAVPPAAPAREASAAVKSSPVPSPSQVFAGRAPATKPIPAAGGRAGSPLPVPGNSDGKLGPDRHHMLEIGEHVAQKWIFERGRDNIRDLLPGPILPPVIDKELLIEAEKELGRSLRPYQEARTWLRDGFWERVYREFGIGVGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E128</accession>
    <name>A0A1H6E128_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91079">
        <property type="protein sequence ID" value="SEG91079"/>
        <property type="gene ID" value="SAMN04489712_12830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13919" checksum="F4365CB75E9289CB" modified="2017-01-18" version="1">MPANPNPVVPGDLFARHQTITGLRALADFLEANPAVPVDEYGEEYSVYTRGHCDTGQRAEVDRVAALLGVTAAESGTRYLASRTFGRITYRIVHIPARSLAENDARNSYWNNITPDPADHDPAAGRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1R3</accession>
    <name>A0A1H6E1R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91512">
        <property type="protein sequence ID" value="SEG91512"/>
        <property type="gene ID" value="SAMN04489712_12943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="14047" checksum="F1246749A7178729" modified="2017-01-18" version="1">MRGGSWLAWCQERGDDAPVVPAWVRQLPTPDSRTPARSRRAIDRLIARRDVVLPEKTLYRMLYETAGRAEEVLGVNIEDLDLDLDLDLAGRRCPVKAKGARAKSRWREQARALLEARTALGGPGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2J4</accession>
    <name>A0A1H6E2J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase DhaK subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91529">
        <property type="protein sequence ID" value="SEG91529"/>
        <property type="gene ID" value="SAMN04489712_12950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="333" mass="35285" checksum="B3CC44137E508708" modified="2017-01-18" version="1">MRKFINEPKEAARETVEGFLAVYGSAFEEVPGALAVKRRELADKVAIVSGGGSGHEPVWLEYVGPGLADAVCQGDIFAAPDPGSIVKTAKAVDRGHGILFLYGNYAGDRLNFDLAAEMLVDDGHKVRTVRVTDDVSAAGPDRPIDRRGIAGGFFVAKVAGAAAEAGLPLHTVQALGQEAADRTRSIGVASGAGTVPGTGEPTFDLPDGEMEIGMGMHGEPGVRRTGMLTADETAAEMIDLLLQDRPVTAEDRVCVLVNGLGATTRAELLIVSRAVRRLLGERRLVIHDIQVGDFATCQEMHGFSLSLFAVSPELRPYYDVPARTSFFSGVNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2Z8</accession>
    <name>A0A1H6E2Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91386">
        <property type="protein sequence ID" value="SEG91386"/>
        <property type="gene ID" value="SAMN04489712_1291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="100" mass="11094" checksum="E7B2779990DFEDE7" modified="2017-01-18" version="1" fragment="single">SDNGAQYCSKDFEAVCRRLGVTRSRAAVGTSADNAAAEAFNATLKRETLQGAHHWPDTRTARLAVFRWITRYNTRRRHSRLGHTSPIDYEKTTGSLTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3E6</accession>
    <name>A0A1H6E3E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPW repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92087">
        <property type="protein sequence ID" value="SEG92087"/>
        <property type="gene ID" value="SAMN04489712_13218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005530">
        <property type="entry name" value="SPW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03779">
        <property type="entry name" value="SPW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="146" mass="15570" checksum="BCE1FCDC2A0A197D" modified="2017-01-18" version="1">MAARTPGARTAGLETHPDLREMRARYDVAAERTVAQIVNGLIMLTGLYLAISPWVVGFRGRTDLAVNNLITGIALTILGAGLAAAFARTHGLTWVVPVIGIWTIIAPWVIYGSAVTRSMIWNNVVTGVVTVLFGAAAMAAMALRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E458</accession>
    <name>A0A1H6E458_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase HrpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92508">
        <property type="protein sequence ID" value="SEG92508"/>
        <property type="gene ID" value="SAMN04489712_13419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="82"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="279"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1302" mass="147023" checksum="3F9DB20B7D02EB29" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5R9</accession>
    <name>A0A1H6E5R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92306">
        <property type="protein sequence ID" value="SEG92306"/>
        <property type="gene ID" value="SAMN04489712_13311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="52" mass="5833" checksum="4F4DBD70285C6DAB" modified="2017-01-18" version="1">MTGMILLIFLALMCAYILRYIAGRLRWSVPAYGGIIIVFMIVVLAVWGQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6D9</accession>
    <name>A0A1H6E6D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar lactone lactonase YvrE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92749">
        <property type="protein sequence ID" value="SEG92749"/>
        <property type="gene ID" value="SAMN04489712_13519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="15"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="299" mass="31558" checksum="ABDA35C6748BB711" modified="2017-01-18" version="1">MFEATAERIATGFSWTECPRWHEGRLVFSDMYNRRILSLPPEGGTLETLVDLSERTGLDGADIVTVGTGFLPDGRLLVNSMFEKVVLVVDGGEVSVYADLRELAVGPINDMVVDAAGRAYVTQLGFNLWAQETPAPSPIIIVEPDGSPRIATEGGELMGANGIAISADGSTLVTAEAFANKITAFDLNADGSLSGRRTFAELDELPDGLCLDADGAVWVAQPPAFRALRIVEGGEVTEQVTVPAAEAGSSTACGLGGPDRKTLYLCCGFEVFDWEASRKGAQGSIWAAQVEVSGGTTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6Q1</accession>
    <name>A0A1H6E6Q1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_13452</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92624">
        <property type="protein sequence ID" value="SEG92624"/>
        <property type="gene ID" value="SAMN04489712_13452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="416"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="700"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="330"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG92624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="823" mass="89042" checksum="8DBB92FED6958727" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E725</accession>
    <name>A0A1H6E725_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93467">
        <property type="protein sequence ID" value="SEG93467"/>
        <property type="gene ID" value="SAMN04489712_1396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="1">
        <location>
            <begin position="238"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="42966" checksum="93634B0ADB8CAA5B" modified="2017-01-18" version="1">MTNRVLDTIMERAEEIRELGPVSERLGRLDDKAAKVLRDSGAIRMLQPAAYGGMEAHPREFAEMVMAAASLDGSTGWVAGIVGIHPWEMAFADPKVQQEIWGEDPDVWIASPYAPMGIARPVDGGYVFNGRWQFSSGTDHCDWIFLGGMLGDAEGKMAMPPSSLHLILPRSDYEIVEGSWEVAGLSGTGSKDIIVRDAFVPDYRVIEFAKVIDGSAPREAGLTNPTYLVPFSCAFPLGITSAVIGITEGALAAHLAYQRGRVQITGTKIKDDPYVLYAISEAAEEIATARTRLLDNVSRMYDKVAAGQEVTFAERAAGRRTQVRAAWRAVQAMNEIVVRSGGNAMRTDNPIQRFWRDAHVGLSHAIHVPGSVYHVSALTDLDIEPPQGPMRSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7Q2</accession>
    <name>A0A1H6E7Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92974">
        <property type="protein sequence ID" value="SEG92974"/>
        <property type="gene ID" value="SAMN04489712_13633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="193"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="37035" checksum="025E554C477D7340" modified="2017-01-18" version="1">MDVAPSDEQRRLVESFTALFGDASPPSRVRAAEPLGFDPALWETVRSAGIVAMAVGEADGGWGAEPLDLALVAEVQGRFLAPVPIVEAQVAARLLARLRTPRAASALAAALAGERTVTMAVHPSREGVARLVPAGAVADDVLVMDGGRLLLVPSGGDHGQVENLGAMPLADLRLGPDAEVLADGPGAEAAYETALDEFLLLTAAAQVGIAARAVEIGVGYVKQRRAFGVPIGSFQSIGHALADSATAVDGARLLTYEAAWAHGTEPGRFAELAAMAFAFATETAREATYRSLHFHGGYGFTDEYDIQLYYRRARAWAAVCLEPRAAYRRAADHRYSAVRTAAPMEEQWTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E808</accession>
    <name>A0A1H6E808_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93086">
        <property type="protein sequence ID" value="SEG93086"/>
        <property type="gene ID" value="SAMN04489712_1378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG93086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="13331" checksum="426A73CA5A03B3F5" modified="2017-01-18" version="1">MEFAVDQHVEQGVNIVKVSGEIDVFSSPRLREMLLDVIEKGPLRLVVDLGDVTFLDSTGLGVLVGIYHRLRARNGSMAFVGANERVRRVFHVTQLTKIFVLHDTLEEALAAEREDSRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAY6</accession>
    <name>A0A1H6EAY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000055">
        <property type="protein sequence ID" value="SEG94917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94917">
        <property type="protein sequence ID" value="SEG94917"/>
        <property type="gene ID" value="SAMN04489712_1551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="12001" checksum="90F3F21FC1F09ED6" modified="2017-01-18" version="1" fragment="single">GDRYPAIIRLWRDAWPSFIPFLAFPAEIRKIVYTTNAIESLNARFRQATRRRGHFPTEQAALKVLYLVIRQPLKNRPNVTGRTPGWKAALNALSLHYGDRITVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB54</accession>
    <name>A0A1H6EB54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDE superfamily endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_14324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94156">
        <property type="protein sequence ID" value="SEG94156"/>
        <property type="gene ID" value="SAMN04489712_14324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG94156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="103" mass="11132" checksum="EA5596749D9C6A22" modified="2017-01-18" version="1" fragment="single">ARLHALPALYPAAAAGLVVLADIGYLGAGIGIRTPRRPHPDIPSPLDADTRTYNRLLRATRALGERAAAELKQRWRALRHVTLSPGRIGAITQAALVLNNAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECI2</accession>
    <name>A0A1H6ECI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein YndB, AHSA1/START domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94505">
        <property type="protein sequence ID" value="SEG94505"/>
        <property type="gene ID" value="SAMN04489712_1489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="18869" checksum="E29856D6490B9ABA" modified="2017-01-18" version="1">MNRPPTGELFRTGTGSDLVLTRTFRAPIEDVWASVTEPDRTARWYGPWEGDAAPGRTIKVQLAFEDQTPWVDMHIDACDPPQRLALSATDEFGAWRIELLLSHADGVTRLRFVHHLENEEQLGEIGPGWEYYLDMLVAARDGSPKPDFDTYYPAMKPYFLALTTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ED62</accession>
    <name>A0A1H6ED62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000056">
        <property type="protein sequence ID" value="SEG94949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94949">
        <property type="protein sequence ID" value="SEG94949"/>
        <property type="gene ID" value="SAMN04489712_1562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="52" mass="5946" checksum="98B4ADE05270A4AC" modified="2017-01-18" version="1">MRFLAAYRAAPSLRWSWPLQRALDASLANVPRSVPRLPGRTLVPSRLEMTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S238</accession>
    <name>A0A1H5S238_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamine synthetase</fullName>
            <ecNumber evidence="7">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44649">
        <property type="protein sequence ID" value="SEF44649"/>
        <property type="gene ID" value="SAMN04489712_10149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="8">
        <location>
            <begin position="104"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="4">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF44649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="474" mass="53329" checksum="5F10151465574E07" modified="2017-01-18" version="1">MFSSAGEVLSYIEAEGIQFVDCRFVDLPGTVQHFTFPVENFGESVFTEGLMFDGSSIRGFQEIHESDMLLLPDPTTAVVDPFRQHKTLNITFFVHDPLTGEPYSRDPRNVAKKAQDYLKSTGIADTVYFGPEAEFYIFDDVRFETKPNAGYYYLDSIEGAWNTGREEAGGNLGAKPPYKGGYFPVPPMDHYTDLRSEMVARLLEVGIKVEMQHHEVGTAGQAEIDFRFGEMLTTADQLMLYKYVVKSVARAAGKTVTFMPKPIFGDNGSGMHCHQSLWKDGSPLFYDEVGYAGLSDTARWYIGGLLKHAPSLLAFTNPTVNSYHRLVPGYEAPVNLVYSQRNRSACIRVPITGSNPKAKRIEFRVPDPSCNPYLAFSAMLMAGIDGIKNKIEPPEPVDKDLYELPPEEARAIPQVPGSLEAVLNRLETDHEYLLEGGVFTEDLVQTWISYKRENELDPIRLRPHPHEFELYYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S3V6</accession>
    <name>A0A1H5S3V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45150">
        <property type="protein sequence ID" value="SEF45150"/>
        <property type="gene ID" value="SAMN04489712_10165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021403">
        <property type="entry name" value="DUF3043"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11241">
        <property type="entry name" value="DUF3043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF45150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="180" mass="20761" checksum="1C14049B6091075F" modified="2017-01-18" version="1">MVKPGGKGRPTPKRSEAQKRRQQYITAPRDRKEAYRQMRERQANNRDKVREGMKQGDERYLLKRDKGPVRRFARDYVDGRRTVGSYLMYSMFVIVLLSFIRTPVTALLMLFAPPLLLAWVLVEGLWISSRVKKLAAARFPGEDLKGVGLYAAVRAMQIRRFRVPAPQVKIGERVEARTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SDF6</accession>
    <name>A0A1H5SDF6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="11">RNAP omega subunit</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoZ</name>
        <name evidence="12" type="ORF">SAMN04489712_101166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48656">
        <property type="protein sequence ID" value="SEF48656"/>
        <property type="gene ID" value="SAMN04489712_101166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF48656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="85" mass="9295" checksum="E369E490B36EF85C" modified="2017-01-18" version="1">MAANSEGITNPSIDELLEVVDTKYGLVSIAAKRARQINAYYAQLGEGLLEYVGPLVETHVQEKPLSIALRETREGLLKAEPIEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SEB7</accession>
    <name>A0A1H5SEB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="12" type="ORF">SAMN04489712_101169</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48754">
        <property type="protein sequence ID" value="SEF48754"/>
        <property type="gene ID" value="SAMN04489712_101169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="11">
        <location>
            <begin position="47"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF48754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="690" mass="73269" checksum="B0998D4BBDA17332" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJP9</accession>
    <name>A0A1H5SJP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50178">
        <property type="protein sequence ID" value="SEF50178"/>
        <property type="gene ID" value="SAMN04489712_101217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05018">
        <property type="entry name" value="CoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF50178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="26050" checksum="A4CD22F743385965" modified="2017-01-18" version="1">MKVTGSATLAAPLPRVWDALQDPAVLASSIPGCHSLEAVGAGAYKMTITAGVASVRGTYVGQVALAEPEPPHSFVLRARGQGAPGTVEATVNVRLSEGADGTRVDYDADAVVGGMIGGVGQRMLGSVARRTAGEFFAAVERVLTAPVPAFAEAAPAEAASRQAPPAPAAVPPTLAQAAPVQAAPAQAVPVQAASPQATPVQAASAQAAPAQAPVPGAMFYGRAAEPAAGPERIAGPMTIAFGAGGLVALAGVVVGYALGRRRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SKJ6</accession>
    <name>A0A1H5SKJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase IV</fullName>
            <shortName evidence="3">Pol IV</shortName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dinB</name>
        <name evidence="6" type="ORF">SAMN04489712_101250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51035">
        <property type="protein sequence ID" value="SEF51035"/>
        <property type="gene ID" value="SAMN04489712_101250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="5">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="3">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF51035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="425" mass="46375" checksum="C89AAB0333330139" modified="2017-01-18" version="1">MSRKQQLHRPGPPPGPPADDTGCGILHVDMDAFFVSVELLERPDLRGRPVIVGGTGGRGVVAAASYEARAFGVHSAMPMSRARRLCPRAVVLPPRHGVYARVSAAVMEIFRSITPLVEPLALDEAFLDVSGARRLLGRPARIGGLIREQVAEQQGITCSVGVASTKFLAKLASTRCKPDGLLVVPADRTVDFLHPLPVAALWGVGERTEEQLRRLGLKTVGDLARFPPDALRRELGNALGDHLHELAWGRDPRPVTPSAPDKSIGAEETFERDIGDPERIRRELLRLSERVGARLRAAGQAGRTISVKLRTAEFRTFTRARTLREPTDLSRVIYITACELYAAAGLHGVRLRLVGVRVENLVPAGRTPRQPALDEPENGWREAERAMDQVTRRFGRGAVRPAALVDPRHDHGDRGDGGDDRDRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SR02</accession>
    <name>A0A1H5SR02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator, OmpR family, contains REC and winged-helix (WHTH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53026">
        <property type="protein sequence ID" value="SEF53026"/>
        <property type="gene ID" value="SAMN04489712_101329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF53026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="222" mass="23228" checksum="DACC306682471D26" modified="2017-01-18" version="1">MREGGGGLILVAEHEPGVAELGRRYLVRAGFETEIEPDPARAPATVARLRPDAVVLDLSAVQGPPGELYRRVAEAAGGAPVVCVVNGGQAAEAGDPRIPALVRPFGPRVLVDAVVLALRGRGRVDDSHVLHAGTVSLDPHARSVTAGDRPVALTATEFDLLQFLMGRPGRVFTREQLLGAAWEPGASAGNRTVDVHIAQLRAKLGDASPIRTVRGVGYAVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SR99</accession>
    <name>A0A1H5SR99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="14" type="ORF">SAMN04489712_101332</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53116">
        <property type="protein sequence ID" value="SEF53116"/>
        <property type="gene ID" value="SAMN04489712_101332"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="67"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEF53116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="419" mass="44294" checksum="7C9C548A9C061117" modified="2017-01-18" version="1">MTIDAARGAASDPANLPDPTGHFGRFGGRFAPEALTAALDELTREFEAAKTDPAFTGELNELLANYAGRPSLLTEARRFAQHAGGARILLKREDLNHTGSHKINNVLGQALLTRRMGKRRVIAETGAGQHGVATATAAALLGLECTVYMGEVDTRRQALNVARMRMLGAEVVPVKTGSRTLKDAVNEAFRDWVATVDDTHYCVGSTMGPHPFPMMVRDFQRIIGVEARAQALELTGRLPDAVVACVGGGSNAIGTFHAFVPDEGVRLYGFEAGGDGVQTGRHAATLSGGSPGVIHGMRTFLLQDADGQTMETHSVSAGLDYPGVGPEHSWLFDTGRAAYRAISDSEAMDAFALLCRTEGIIPAIESAHALAGALQLGPELVAELGGEATLLVCLSGRGDKDMHTAAQWFGFMTGEESAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TBD7</accession>
    <name>A0A1H5TBD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60099">
        <property type="protein sequence ID" value="SEF60099"/>
        <property type="gene ID" value="SAMN04489712_101554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF60099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="97" mass="10874" checksum="045B558C61E0B9EA" modified="2017-01-18" version="1">MPGFAADHPVYLDGSVPMDGLFNALLEVASEVWVLRDRFAVLEQLLRERGSVTRDDIDLFQPGPELRERLAAERRAFLERVLESVAAATPPGQERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TNX7</accession>
    <name>A0A1H5TNX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64480">
        <property type="protein sequence ID" value="SEF64480"/>
        <property type="gene ID" value="SAMN04489712_101693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="73"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF64480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="28092" checksum="186A52C5F7CC9F31" modified="2017-01-18" version="1">MDKPLKNPPTYLITSVDHALRIAAMLQLEGELTVSEVAERLGVARSTAHRLLAMLVYRDFAVQDERRLYRAGPVLELAAHSPSVASRLRAAALPHLHRLVDVLDESANLAVRTGDTVRFIASVECTQSLRVGSREGMVFPAHRTTAGLLLLAELTDEELAAVYPAERYADRPEDRPDLARLRTRLARVRRNGFVLNQGRSERGVVALGVPIRAPDGDALAGLSVSMPSGRYDRRRLPALVDILSRAAGAVGADLARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TWR0</accession>
    <name>A0A1H5TWR0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_101752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66471">
        <property type="protein sequence ID" value="SEF66471"/>
        <property type="gene ID" value="SAMN04489712_101752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF66471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="29973" checksum="A7372DD97CEF023D" modified="2017-01-18" version="1">MSMPIAPAIPTTPAERLRWALSDAWVVSGRELIHWVRNPVVILNTLLFPLIMVLLFGYVFGSAMRVAGGGDYREFLMPGMFGQTMVFGVISTVYVVAANAARGVTDRFRSMPVSSFGVLMGRVIADMLTSTLDLVILMLCGLLVGWRAHHGLGSALAAAGLLLLLRFALVWVGICMGLRLTPEGAGAAWMPLFPLTLLANTFVSPELMPAWLRIIAEWNPLSATVQACRELFGSPGLSGGSWAAEHAIELAIGWPLLITVIFLPLSIRRYRRLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UU58</accession>
    <name>A0A1H5UU58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78526">
        <property type="protein sequence ID" value="SEF78526"/>
        <property type="gene ID" value="SAMN04489712_10225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF78526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="75" mass="8072" checksum="F05BF47AD9B1E667" modified="2017-01-18" version="1">MESLKLTEVTELPSVVDIVTAARALGLSRTYAYELAKRGEFPCKVIRIGTGYRVPTAPLLDLLGLATPTGPARKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V9V2</accession>
    <name>A0A1H5V9V2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">SAMN04489712_102212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83578">
        <property type="protein sequence ID" value="SEF83578"/>
        <property type="gene ID" value="SAMN04489712_102212"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF83578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="425" mass="43827" checksum="CF21910A199B95B0" modified="2017-01-18" version="1">MPTQNWSAPMASGPVDATVALPGSKSMTNRALILAALADEPTRVVRPLRSRDTLLMAQALRDLGVRVAEEGDDWLIAPGERAPLAAPVRVDVGLAGTVMRFLPPVAALADGRVTIDGDPRARERPMRPIIDALRALGAEIDDGGRGCLPFTVHGRGALAGGAVTIDASGSSQLVSGLLLAAPRFAKGVEVRHEGPPVPSAPHLAMTVQMLRDAGAAVETAGDLWRVAPGALRGGESVIEPDLSNAAQFLGAALVTGGRVTVPGWPADTTQPGDALRGLLAAMGGQVSAGPDGLTVQGSGTLHGLDADLRDVGELTPVIAALAALAGSPSRLTGIAHLRGHETDRLAALAREINALGGDARELPDGLEIRPRPLHGGLFHTYDDHRMVMAAAVLGLAVEGVEVENVATVGKTLPDFTDLWTRMLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VFW4</accession>
    <name>A0A1H5VFW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Surfactin synthase thioesterase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86104">
        <property type="protein sequence ID" value="SEF86104"/>
        <property type="gene ID" value="SAMN04489712_102305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF86104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="29225" checksum="4C1F356FDE75CACC" modified="2017-01-18" version="1">MNAVETLSGVIRPRPIDGPEVRLFLLHHAGGSHTAFRRWVRHLPAGYEACLIETPGRGRLAGVPAKRRMADLVGHLLADVDPWLDRPFAVFGHSMGGLVGYELVRALHARGGPLPVWLGVSGHPYDRSPEYERTYLLPDERFRELMGALGGVPRQILDEPRYWRLFEPLMRADLELCQTWEPDPAAAPLPVPMTAFAGLSDAVAGPARIAGWAARSSRFLGVRYFEGGHFHLRERPVPVIGGIVADVAAQLPGHVREPRANGERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VIE4</accession>
    <name>A0A1H5VIE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytoene dehydrogenase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87135">
        <property type="protein sequence ID" value="SEF87135"/>
        <property type="gene ID" value="SAMN04489712_102338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF87135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="491" mass="52413" checksum="0DF59963999B1EC4" modified="2017-01-18" version="1">MVDAVVVGSGPNGLSAALVLAAAGLKVEVYEAARRPGGGARTEQLTLPEFWHDVCSAVHPMALASPFFRAFDLGRHGVELLQPQVAYAHPLDGGRAGLAWADLDKTAEGLGADGAAWRSLFGPLVERWQGIVTTAMSDYRHPPRDPIGVVRLGLRLLEQSSPLWRARFRGDVAPAMMAGTSAHAIAPVHRPAATGAGLLLGTLAHAVGWPIPRGGSVAIVNAMTRALEDRGGRIITRHQVESLAELPRARAYLLDTAPAGLLRLAGDHLPDGYARVLRRFRYGGAVCKVDFALAGPVPWAAPGCELAGTLHLVGSEREAAIAEREVTAGRHASRPYVLASQPGVVDDSRAPRDHHVLWTYAHVPNGSTRDVSDAVIAQVERFAPGFRELILAKRVVTAAEQPAHNANYVGGDISGGATTAWQMLMRPVPRWDPYRTPLPGVYLCSSSTPPGQGVHGMAGLHAATRVLRQRFDIRADPLELVRSLDHRAPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VL79</accession>
    <name>A0A1H5VL79_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SAMN04489712_102367</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88105">
        <property type="protein sequence ID" value="SEF88105"/>
        <property type="gene ID" value="SAMN04489712_102367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="17"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="361"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="194"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="332"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="54"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SEF88105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="480" mass="51874" checksum="827F26418314E7B2" modified="2017-01-18" version="1">MRASSRPNIVQGMSTHFDVVVLGAGPGGYVAAIRSAQLGLKTAIIEERYWGGVCLNVGCIPSKALLRNAELAHIFTNERKLFGIEVDGEVRFDFGAAFQRSRQVADGRVKGVHYLMKKNGITEFTGRGTFTDPNTLQVQPSDGGQTQTVTFDHCIIAAGAHPRLLPGTSLSERVVTYEEQILDEKLPESIVIAGAGAIGVEFAYVLHNYGVKVTIVEFLDRMVPLEDAEVSKELARRYRKMGIDVLTSTRVETIDDSGEKVKVTVTGKDGSQQTLEADKVLQAIGFAPNVEGYGLEKTGVALTERGAIDVDGRCRTSVPHIFAIGDVTAKLMLAHAAEAMGIIAAETIADAETMELDYVMIPRATYCQPQVASFGYTEAQAREEGFDVKVAKFPFTANGKAHGLGDPNGFVKIISDARYGELLGAHMIGPDVTELLPELTLAQQWDLTVHEVARNVHAHPTLSEAVKEAVHGLAGHMINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VQV7</accession>
    <name>A0A1H5VQV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-serine deaminase, pyridoxal phosphate-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89620">
        <property type="protein sequence ID" value="SEF89620"/>
        <property type="gene ID" value="SAMN04489712_102420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="21"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF89620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="398" mass="42711" checksum="FA09D1DCACF5D557" modified="2017-01-18" version="1">MDLRKRYDTATAALEAPLAIVDLDAFRANAADLVRRAAGKPIRVASKSVRCRALLEEVLSLDGFAGVMAFTLPEALWLAEHRISDDILVAYPTADLTAIARLAADEHALATVTLMVDSPEHLDLIGRAARDGAGAPVRVCLDIDAGYRALGGRIRIGARRSPVHDPGQAAGLATLIDRTPRLRLVGLMAYESQIAGVGDDPPGNPARGRVIRAMQSRSRIELARRRAAIVQAVRRVRPDLEFVNGGGTGSVEKTTAERAVTEVAAGSGLYQPHLFDYYTNFRGRPAALFALPVVRRPGPGVVTCLGGGYLASGPADRLRLPQPYLPEGLSYDANEGAGEVQTPLLGTAADRLTLGDRVWFRHTKAGELCERFDALHLVEGDTLVDTVPTYRGEGQTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W9G5</accession>
    <name>A0A1H5W9G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96043">
        <property type="protein sequence ID" value="SEF96043"/>
        <property type="gene ID" value="SAMN04489712_102636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF96043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="44555" checksum="688393DD91CD429E" modified="2017-01-18" version="1">MTELELTADEARRIQLRAQGLLGAQTRPRGVAGVLEQLGAVQLDTISVLARSHELVPYARLGAVGREAVENAYWDTSTGTGAAFEYWAHAACVLPMDEWPLLAFRRRAFRRRGWRWHKISQEACEVVLKRLRADGPLTMRELGGAKASADWWDWSEQKIAVEWLLDIGEVVCARRTGWRRVYDLPERVVPAALLDREPEDAECLAHLVGRAGRALGVATRADLADYYRIKGEQVDAVIEAAGLVPVRVAGWRHRAWADPRALEAPPRGRHAVTLLSPFDSLVWDRARTLRMFGFEHRLEAYVPKAKRVHGYFTMPLLAGGRLIGRVDPAREKGVLVARQVSVEPWATSTPARAREAVAALSTALWRAAGWVGCRDVRVEVMDPPELTALVERALREGPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XD03</accession>
    <name>A0A1H5XD03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09310">
        <property type="protein sequence ID" value="SEG09310"/>
        <property type="gene ID" value="SAMN04489712_103188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG09310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="26553" checksum="9A69FBAF625AC059" modified="2017-01-18" version="1">MNAWDDPERREELTWRREREPDRADGLAELIRATIDEDTRDLVFPGAMAERVIHGSRARRPWSRIHATILVGVVLASGMGVVSAAAVVPGLVSHGGEPTMTAPSTGAGPSAAPDPSRLVVVGYVPRGWRRVPLVTMPAGDADVRAWTVRYEPQGVRRQTLTVRVAVGRDGLTEVRRTETARGSVLRPYAVTVGRALTVPPVVVGRGRPAETRVYWEPRAGLLVGVRGVGVSSAEIRKVVSGLRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XEZ3</accession>
    <name>A0A1H5XEZ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10384">
        <property type="protein sequence ID" value="SEG10384"/>
        <property type="gene ID" value="SAMN04489712_103227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG10384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="20543" checksum="1DF23D30AA9BB4EC" modified="2017-01-18" version="1">MNAEELLDLCPVIPVVVLHDAAAAVPVARALVAGGLPAIEVTLRTPAALEAIKRIAAEVPDAVVGAGTVVTPAQAAEAAGAGASFLVSPGCTGSLREAMTGTGLPFLAGVSSASEAMALLEHGVTAMKFFPAKAAGGPAYLKALAGPLPQVRFCPTGGITPENAGEYFALPNVGCVGGTWLTPDDAVRAGDWDHIEALARAAAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XLF4</accession>
    <name>A0A1H5XLF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12552">
        <property type="protein sequence ID" value="SEG12552"/>
        <property type="gene ID" value="SAMN04489712_103307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289601" evidence="2">
        <location>
            <begin position="33"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG12552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="721" mass="72549" checksum="97D64FF95793B754" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XLR8</accession>
    <name>A0A1H5XLR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dinuclear metal center protein, YbgI/SA1388 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12699">
        <property type="protein sequence ID" value="SEG12699"/>
        <property type="gene ID" value="SAMN04489712_103312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG12699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="28479" checksum="04A0C584F3F3EF40" modified="2017-01-18" version="1">MRLSQVITVLERLYPPEWAQSWDAVGLVCGDPDAEVRRVLLAVDPVAAIADEALDQGADLIVTHHPLLLRPVNSVAATTPKGRLIHRLISSGVALYTAHTNADVADPGVSDALARAVGLTGPLTPLAPSPDDPARGLGRIGELAETVPLREFAARAAAGLPATAWGLRVAGDPERPVRIVAVCGGAGDSLLETARRAGVDVYLTADLRHHPASEFREAGGPALIDAAHWATEWPWLADAQRHLAQALDLKSHVSTLVTDAWTLHFEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XS75</accession>
    <name>A0A1H5XS75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific DNA recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14594">
        <property type="protein sequence ID" value="SEG14594"/>
        <property type="gene ID" value="SAMN04489712_103386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG14594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="504" mass="57555" checksum="91F87F6FBDF601F3" modified="2017-01-18" version="1">MTATDRDLIPVVDYARASVDKAKDEHTVEDQQAANEKTAGRLGCRIVARFADNDKSAAKADVYRDDFEEMLKVLRKGKLSDGTPVMGCIVTADDRLVRRAGDYERFVDAITHEEGRVYADKRGFKDLYSEDVESMGLMGAVISRMEVKRTRRRVRNWHRARAERGLPPKAHRAFGWMADGTTIDQGEAALIRKAIDELISGRSQASIVREWQAKGVKTPRGYDWTTGTLRKMLLNPRLCGWRMIQGEIVEVDGKPVTGQWEPIISPERWQAVRAFYDARRGKIITRDGAVRPMAPDHREHSYLLTGVLRCGRILPDGSMCGKKLRVVNDRKTGVFRYYCQDKTQGGCGGLSRRGDKLEEFISEAVLAKLEERAKSARRDIGPWPRERELIELQEQLAELRAQWGKRKVSNALFFAEVERLEPEIAKLRAERERYELASQQSETDISDIRRRWYSETDDDRLDLGQKRAYVRGCFLAIIVHPAGKGNGSRTTFNPDLLELIWRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XUC3</accession>
    <name>A0A1H5XUC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15047">
        <property type="protein sequence ID" value="SEG15047"/>
        <property type="gene ID" value="SAMN04489712_103403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046040">
        <property type="entry name" value="DUF5998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19461">
        <property type="entry name" value="DUF5998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG15047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="20143" checksum="E9EB20AD28F7A08F" modified="2017-01-18" version="1">MRDTRATAHGLRTAIERSGYYPALVADAVESALGNETVLAYVVHHEATFDPAMEVRRHVTVLVLSPTRLLVCHTDEHPPGEGVPQAHASTTTEAVRLDRIQSVAVTRVVPDPASYVPGVPPTEVVLTIGWGAIAHIDLEPATCGDESCEADHGYTGNVTADDMSLRVSEAADGADAVVQVLAFAQALSAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XX26</accession>
    <name>A0A1H5XX26_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16349">
        <property type="protein sequence ID" value="SEG16349"/>
        <property type="gene ID" value="SAMN04489712_103453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026335">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04269">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG16349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="378" mass="41527" checksum="60B100F3DF1B72DD" modified="2017-01-18" version="1">MPFREFVLKIHGRCNLACDYCYMYQGADQSWRSRPAVMSAAILRQTAQRIARHARAHGLAEVEIVLHGGEPLLAGPAFIDFAATELRRGLPAGHRVGIGVQTNGLLLDERMLALLAAHDIGVSVSLDGDRAAHDRHRRRANGRGSHAAVRRALKTLTDRHRELYRGLLCTIDLANDPVAGYEALLETAPPRIDFLLPHGTWSEPPPGRGPDAGTPYADWLIAVFDRWYGAPVRETGIRLFEEIINLVLGGRSRSESVGLSPVALIVVDTDGTMQQVDTLKTAFPGAPETGLTVTEHEFDDALRHPGVVARQIGRAALCAQCTACPVGDICGGGCYTHRYRRGHGYRNPSVYCLDLKKLIMHVHRRIDADLARVRGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YPR0</accession>
    <name>A0A1H5YPR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26089">
        <property type="protein sequence ID" value="SEG26089"/>
        <property type="gene ID" value="SAMN04489712_104118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01026">
        <property type="entry name" value="TOPRIM_OLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034139">
        <property type="entry name" value="TOPRIM_OLD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="195"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="669" mass="74691" checksum="4B2375BEB921AF6B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YRW5</accession>
    <name>A0A1H5YRW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26873">
        <property type="protein sequence ID" value="SEG26873"/>
        <property type="gene ID" value="SAMN04489712_104153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG26873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="29424" checksum="0D1AC760F729739E" modified="2017-01-18" version="1">MERVEWESLPPAVRDAVQEHIGAVVKIEPIPEGKNSALVAVAHTSTDRVFLKGARACEPAKAAQLEREAAINPYVTAIAPALAFEAAEDGWHLLGFEYVCGHRADYAPGSPDLPKVLETLDALDRLPCPQGGVQLPWFEARLSNYAPPQHLRHFTGRALLHTDLTPGNMRVTPQGAMLVDWATASRGADWVNPADLVLCLIACGHTPRDAEAAVTDVTSWRNADPEAINAYARTTAATWLELYFTATHPWARAAVKAAQQWAMHRWETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YUM1</accession>
    <name>A0A1H5YUM1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26966">
        <property type="protein sequence ID" value="SEG26966"/>
        <property type="gene ID" value="SAMN04489712_104157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG26966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="297" mass="31702" checksum="91F45DEEFEF2196A" modified="2017-01-18" version="1">MTANDQTTGHRDETLASVLVTGQQPSRLQRRGRYLAESMRHPGKMLPAIAAQVISAYTRPGDHVLDPMCGIGTTLVEAIHLGRNAAGMEYERDFARMAADNVRHAQGQGATGAAEVVCGDAHTVTTTLSGLCGRVALVLTSPPYGSHTHGHVRSGRDNGGGKLLKQDHRYSHDRGNLAHQGIDDLLHGVGRILGGSAELLRPGGVLAVTVRPIRVKGELVDLPGRVIETAGRAGLVLTDRFAALLCGLRDGGLVTRASFFQMLETHRVRERGMPACVTAHEDLLIFQRARDVSGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z8K8</accession>
    <name>A0A1H5Z8K8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">SAMN04489712_104419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32632">
        <property type="protein sequence ID" value="SEG32632"/>
        <property type="gene ID" value="SAMN04489712_104419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG32632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="61" mass="6989" checksum="474783C9FF890A85" modified="2017-01-18" version="1">MAKKALIAKAARKPKFGVRAYTRCSRCGRPRSVYRKFGLCRVCFREMAHRGELPGITKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZAF8</accession>
    <name>A0A1H5ZAF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33368">
        <property type="protein sequence ID" value="SEG33368"/>
        <property type="gene ID" value="SAMN04489712_104452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG33368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="24496" checksum="1E951FC8926D1322" modified="2017-01-18" version="1">MNATIALITLRAMLGRRRALLLFALPLLLLMLAAALRITGNADLEVSASVLQGFALATVLPLLALIAGTGVIGPEIDDGQIMYILTKPIRRHVVVVTKLVVAIALVVVFAVMPTLMAGLVLTGMTADLAVAFTAGTLVAGVAYGAVFVALAVASRNAVTIGLLYALVWESLLGNFAPGARSVSIQQWGLSVADAITSTSAVEASVRTPAAVLLLVCVTVLATVLAVMRLRTLSVAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZCM8</accession>
    <name>A0A1H5ZCM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, OmpR family, contains REC and winged-helix (WHTH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33485">
        <property type="protein sequence ID" value="SEG33485"/>
        <property type="gene ID" value="SAMN04489712_104457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="143"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="143"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG33485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="243" mass="26727" checksum="5C88A34AD5A189D4" modified="2017-01-18" version="1">MSGFGDIRGRDPDVADNDAVATILLVEDDPSARAALDLALSRLGHGVISQTTGEEALQTLRARRPEIAVLDVMLPGLDGIELCRRIRRDDALPVILLTARGDDLDVVLGLEAGADDYVVKPVEPRVLDARIRAVLRRAENTPADRTSHGDLVIDRAALKVTKGGRDLRLTPTELRLLLELARRPGRALTRRHLLAAVWEHAYPGDSRLVDACVQRIRAKIEDEPSEPRLIETVRGFGYRFCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZY25</accession>
    <name>A0A1H5ZY25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41042">
        <property type="protein sequence ID" value="SEG41042"/>
        <property type="gene ID" value="SAMN04489712_10562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009029593" evidence="1">
        <location>
            <begin position="35"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="2">
        <location>
            <begin position="384"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG41042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="612" mass="63622" checksum="A51D570BFC9115F1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A5D6</accession>
    <name>A0A1H6A5D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tight adherence protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_105205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43582">
        <property type="protein sequence ID" value="SEG43582"/>
        <property type="gene ID" value="SAMN04489712_105205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045980">
        <property type="entry name" value="DUF5936"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19359">
        <property type="entry name" value="DUF5936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5936" evidence="8">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="152"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG43582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="295" mass="32004" checksum="AB5204A47E0C19FF" modified="2017-01-18" version="1">MVVVMASGGALCVVAALWGYALARGGERVAPSALAGQATGPAKPQGQPLHRMVMPFGRPFTGWAMGRLRPWHPRIRRRIDAAGRPAGMTVESYVQSTMGYVVLFGSLSLLLVLSGQLLIGLLFLVGVLQNELNLVLRASMRRDQIERSLPDFLDVLAVTVSAGLSFRHSLARVAESMPGPLADEFFITLRQMELGTPRRDAFQNLRERNRSGMLGQFVTAILQAEELGAPLASALIGIAQDMRRESAQWAKRKAQRVTPRVTLVTTVMAMPAMGLLMLGALLLGSESDFGNVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A6B8</accession>
    <name>A0A1H6A6B8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44001">
        <property type="protein sequence ID" value="SEG44001"/>
        <property type="gene ID" value="SAMN04489712_105227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016628">
        <property type="entry name" value="ATPase_SAG2001_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015040">
        <property type="entry name" value="ATPase_SAG2001_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="469"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="821" mass="89975" checksum="3C20BD9933A194C5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A6L7</accession>
    <name>A0A1H6A6L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43677">
        <property type="protein sequence ID" value="SEG43677"/>
        <property type="gene ID" value="SAMN04489712_105211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG43677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="379" mass="39992" checksum="A29212943E21EEDF" modified="2017-01-18" version="1">MTAVLVAVDVPSCGVIREVRAGRLTTGDAAEPEVTAFIDRLARALRGHRAALVLYPSWRPEPTERLVRLARGVLRTDRIAAVPLDLPPLALSLIADQLAYMARHVAPGVLTGLARRLAAEVVAGAWVNSVARLEHIETGLGPHLSSYLPGSAFMVTAGAQAGVHRITEGAPVARLNTRPTDPVVVLASTGDADPSWLHTAFKPHIAAAVVTLVEPQPLSPVYWGTRKYVEFVAFSGHPGALTRAARAAKGRPCRWCGEVTALTVCAFCSMVQPPPPRRPPSRPSAPAPGWHPRGAGPAQGTQTNGSVQGPRAAGPARAPRAAGPPQPVWRPPPASHTQQAPPARSAQRVPPPQAVRPAGTERHRASQPRISTSQPVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9W1</accession>
    <name>A0A1H6A9W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall-active antibiotics response 4TMS YvqF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45488">
        <property type="protein sequence ID" value="SEG45488"/>
        <property type="gene ID" value="SAMN04489712_105305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="1">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG45488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="213" mass="23855" checksum="7403551B2E1847B5" modified="2017-01-18" version="1">MAGERYRLGVEVPWRPVPAEPVTRVHDLRASDADRERVAQVLSEALADGRLTIEEHAERTSLVYSARTLGELTGLTGDLTPAEAQPILVDDRPLQATFGSLRREGRWVMPVRLPLLALFGTVELDLREAILQRRHVVLDSLVLCGRIRLLVPDGVRVDVTGRSILSTREVRVRPADDGPTVEISGRMVLGSVRARAPRRTLRERMRGRLRKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXC5</accession>
    <name>A0A1H6AXC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53273">
        <property type="protein sequence ID" value="SEG53273"/>
        <property type="gene ID" value="SAMN04489712_10683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG53273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="34433" checksum="2C4A0BC112EC4380" modified="2017-01-18" version="1">MNVVRLAGGRSVLLRPRAAAVGTGLVLLAAAIGVVSIGSGDYPMSPAEVVRTLTGGGDPAQHFIVNELRLPRVVTALLVGAALGLAGALFQSLTRNPLGSPDILGFTQGAAAGAFLAVVLGGGSLALAGGAMAGGVLTGVVIYALASRGGLHGYRLVLTGIGCTAILTGVNGYLLTRAQLMDAARAMLWFTGSLDGRGWEEAVPLLAGMAVLVPVVLLGCGRALPVLEMGDDLASGLGVRVRRLRLVLLAAAVLLTSLAAAAAGPVAFVALTAPQVARRMTKAPGPNPLVSMCTGAALLVGADWAAQRLFAGHQLPVGVLTGLLGGGYLVWLLIVQRRSGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B0H8</accession>
    <name>A0A1H6B0H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfur acquisition oxidoreductase, SfnB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54353">
        <property type="protein sequence ID" value="SEG54353"/>
        <property type="gene ID" value="SAMN04489712_106152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023922">
        <property type="entry name" value="S04_starv_induced_SfnB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04022">
        <property type="entry name" value="sulfur_SfnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="4">
        <location>
            <begin position="255"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG54353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="412" mass="44675" checksum="890A2B384118660F" modified="2017-01-18" version="1">MTTFDEAVAPPAAGRAHVIRTDEEAVETAARLAAEFAPGAAERDARRLLPRPQLDRLSDSGLLAITVPREYGGADVRADTLAEVYRLLAEADPNIAQIPQSHVVYLRVLAQQGDARQREYFFGEALAGRRFGNAQSEAGTRHVQDYRTRLVPDGNGGGYRLTGEKHYCTGALFAHWVPVLAQLDVPGEGDRLHVAYVPRGAPGLKVVDDWSGMGQRTTASGTVRLQDVWVPAERVVPHHLTFTGPQIHGSYAQLLHTAIDVGIAGGALREAAEFVRTKSRPWFESGVSTAAEDPLLVQRFGELAIAERSARALLAEAGRAVEVARHTLTEEATAAASIAVATAKAVADRACVEISSALFEVSGTRSSLEGLNLHRHWRNARTHTLHDPVRWKVQHIGRYTLNGTPPPRHGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B1P2</accession>
    <name>A0A1H6B1P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54530">
        <property type="protein sequence ID" value="SEG54530"/>
        <property type="gene ID" value="SAMN04489712_106163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293227" evidence="1">
        <location>
            <begin position="28"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG54530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="23445" checksum="BE01AACF6A5C5877" modified="2017-01-18" version="1">MHVLARFATPVLAAATVLGLVATSASAAPATIRRGGPAELPYSGAIRFDNLGPLSVNARILGVNVTAQCSTAVLNGTLTSSSTGSLNSATVTGCSSNVGGSANITFQNLPYTDATVDYAPIPGGRDGTLTFTDPDLRIRANLTVFGISATCYYGFGSTVSSLTFDLYNPDNPNRPNPSVAEAQGKMNNASLDRLSGSGAICPATGTANGAGIVRGEKTAGSGVFDQTLYATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5S8</accession>
    <name>A0A1H6B5S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55745">
        <property type="protein sequence ID" value="SEG55745"/>
        <property type="gene ID" value="SAMN04489712_106255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG55745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7050" checksum="6BB5E6E2C95A5382" modified="2017-01-18" version="1">MGLMRADGAPVTVTRRCQGCGACLLTCPEHAIRPYGPALEVRADLCTGCLECVEICPVDAIDATEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BFF8</accession>
    <name>A0A1H6BFF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59491">
        <property type="protein sequence ID" value="SEG59491"/>
        <property type="gene ID" value="SAMN04489712_10772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="132"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="26876" checksum="A064F4F094F57897" modified="2017-01-18" version="1">MFRWVWAFVDRPLARLEESADFWTTVTGSSLSPRRGNAMEFATLLPVAGDAHLKLQGVHDGGGAHLDFEVEDIPEAEKTACGLGAEVVRREPGLSVLRSPAGQLFCLVPWEGADSRSPAVTGPDGASSLLDQVCVDIGPADYENEVAFWADLTGWELRSTGSSEFRRLVPDASLPVRILLQRLGEDRPASSHLDFACSDVAAVRTWHEKHGAQVIDVRTAWTVMRDPVGGIYCLTARDPRTGRRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BG27</accession>
    <name>A0A1H6BG27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein TerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59718">
        <property type="protein sequence ID" value="SEG59718"/>
        <property type="gene ID" value="SAMN04489712_10786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="20063" checksum="D11EADA25076709F" modified="2017-01-18" version="1">MGVSLSKGGNVSLTKQAPGLTAVTVGLGWDVRTTTGTDFDLDASAIVVDASGKVLSDQHFVFFNNLKTPDGSVEHTGDNLTGAGEGDDEQVKVNLAGMAAEAQRVVFAVSIYDADSRGQNFGQVRNAFIRVLNQGDGSELARYDLSEDASTETAMVFGELYRNGAEWKFRAVGQGYASGLAGIATDFGVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BG61</accession>
    <name>A0A1H6BG61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59226">
        <property type="protein sequence ID" value="SEG59226"/>
        <property type="gene ID" value="SAMN04489712_10755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG59226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="127" mass="14072" checksum="B38316895D159B0A" modified="2017-01-18" version="1">MSRDGEGPRRVLVTSPRMRATRRPRHPVTREIDEQTGLGEAYMRSLVRAQLRLGLGVCAALGVVVGGLPLLFVLAPELRGLDVGGLPLPWVLLAGLVYPGFVVCGRWYVRHAERNERDFADLVDRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BI33</accession>
    <name>A0A1H6BI33_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neutral metalloproteinase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_107127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60373">
        <property type="protein sequence ID" value="SEG60373"/>
        <property type="gene ID" value="SAMN04489712_107127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M4" evidence="9">
        <location>
            <begin position="111"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="10">
        <location>
            <begin position="194"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG60373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="365" mass="39466" checksum="75804AB178FFD75C" modified="2017-01-18" version="1">MTGSGLPNPVKRVAWITVSCQRDLMRCTIVPPHMLERVARTDDPALRDMARRTLVLSATQRVERRTLPVATADPSEDFAPRRTVHDAATRQELPGKAVRSEGDGPTGDGVVDQSYDWLGVTFDYFEAVHRRNSIDGAGLSLVSTVHYGVDYANAFWNGEQMVYGDGDGTLFTGFTGPLDVTGHELVHGVTQYTANLEYFGQSGALNESMSDVFGSLIKQWHRGQTADEADWIIGEGLLAEGVSGVGLRSLKAPGTAYDDPRLGKDPQPGHMRDYVETYRDNGGVHINSGIPNRAFHLVATALGGHAWEKAGRIWYETLTGRAMSPNTGFAAFAAATIEAAGRLYGAASIETAAVKEAWDGVGVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BMQ3</accession>
    <name>A0A1H6BMQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty-acyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_107261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61964">
        <property type="protein sequence ID" value="SEG61964"/>
        <property type="gene ID" value="SAMN04489712_107261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="418"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG61964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="506" mass="53540" checksum="41B4ADCA44A43D62" modified="2017-01-18" version="1">MRNQGLGSWPARRARKTPQRTATIHQDRRQTYAQLNERVTRLAHALRELGVRRGDRVAYLGPNHPSFLETLFAAGLLGGVFVPLNTRLAGPEIAFQLADSGASALVYGPSHAELVDGGARAASVRAHVALAGPRPGAHGYEDLLAGAAAEPIDEPVALDETCMIMYTSGTTGRPKGAALTHGNITWNAINVLVDHDLLADEVALVSAPLFHTAGLNMLTLPVLLKGGCCVLVPGFDADGTLDLIERHRVTFMFGVPTMFRQVARSPRWAAADLSSVRLLTCGGAPVPPSLIAAYAERGLTFLQGYGMTEAAPGTLFLDAGHATAKAGSAGVPHFFSDVRVVGPDLTEVAPGETGEVIVSGPHVMPGYWGLPEETAAVFTDGWFHTGDAARIDEDGYAYIVDRMKDMIISGGENVSPAEIEKAVLADPDVLDCAVIGVPDPTWGEVGRAVVVARPGSGLTERRVLDGLAGRMAKYKIPKSVVFADELPRNAAGKVLKSVLRGTYGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUP2</accession>
    <name>A0A1H6BUP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64451">
        <property type="protein sequence ID" value="SEG64451"/>
        <property type="gene ID" value="SAMN04489712_10825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG64451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="189" mass="20827" checksum="A27DDA19162987F1" modified="2017-01-18" version="1">MRKRGRQEGDARTRILDAAEELFAADGYEATATARVARRAKVPKGLVFHYFPQKIDLLVALVEERTFIEVLPAESVEAMPGDPAGTLSRLARRFPLRASPAMRRILFREADTHRSVRDRLRSLNGEVLRRARGALEVALPGTRGDAARLEVAAATFTAVLLYQENLSQLTGEHIDPDAVADLIARALGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C240</accession>
    <name>A0A1H6C240_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67002">
        <property type="protein sequence ID" value="SEG67002"/>
        <property type="gene ID" value="SAMN04489712_108245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG67002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="130" mass="14275" checksum="51AA504C4314C5F0" modified="2017-01-18" version="1">MELDGCAVRVVDAPRVASVRERMPAERDLADTAEVFGLLSDPGRLRLLVALLDGELCVCDLAAVSGMSESAASHALRLLRAHRVVSVRRSGRMAYYRLADAHVRMLLDLAVAHIEHTQVVEEAVHPEREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2Z4</accession>
    <name>A0A1H6C2Z4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_108276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67318">
        <property type="protein sequence ID" value="SEG67318"/>
        <property type="gene ID" value="SAMN04489712_108276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG67318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="6715" checksum="7097D1DD5D34986D" modified="2017-01-18" version="1">MKITVDADRCRGHGVCCALCPEVFDLSDDGYAVVLTPEVPAEFRETVRTAMGQCPERAIAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C370</accession>
    <name>A0A1H6C370_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PqqA peptide cyclase</fullName>
            <ecNumber evidence="7">1.21.98.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coenzyme PQQ synthesis protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pqqE</name>
        <name evidence="9" type="ORF">SAMN04489712_108285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:56836"/>
            <dbReference type="Rhea" id="RHEA-COMP:14800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:141026"/>
            <dbReference type="ChEBI" id="CHEBI:141027"/>
            <dbReference type="EC" id="1.21.98.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with PqqD. The interaction is necessary for activity of PqqE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the radical SAM superfamily. PqqE family.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.4" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67414">
        <property type="protein sequence ID" value="SEG67414"/>
        <property type="gene ID" value="SAMN04489712_108285"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009975">
        <property type="term" value="F:cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00660">
        <property type="entry name" value="PqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011843">
        <property type="entry name" value="PQQ_synth_PqqE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00280">
        <property type="entry name" value="coenzyme_PQQ_synthesis_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02109">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="7"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG67414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="40375" checksum="FAA62C43AB1D6525" modified="2017-01-18" version="1">MSAEAEMRPPIGLLAELSYRCPLHCPYCSNPVALGDHRRELTGEQWCRVLTEARELGVLQLHLSGGEPLTRRDLPELVRHARRVGLYSNLVTSGVGLTDRRLAALVEAGLDHVQLSVQDSAAERSDRIAGTRSFERKRAAARAVKRAGLPLTVNVVLHRHNADRVAELAELAVRWGADRLELAHTQYYGWAALNQARLLPAREQVERSRAAARDAAERHGDRLGIVYVVPDLYEDRPKPCMHGWGRRHLVVRPNGDVLPCTAAGEIPGLPIENVLGTPLAEIWFSSESFNRFRGTDWMPDPCRGCPLREVDFGGCRCQALRLLGDASATDPVCALSPHHSVVTRLVEQAQAAQAGPDAASGPMVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C813</accession>
    <name>A0A1H6C813_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multisubunit sodium/proton antiporter, MrpF subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69120">
        <property type="protein sequence ID" value="SEG69120"/>
        <property type="gene ID" value="SAMN04489712_10951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG69120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="88" mass="8895" checksum="21C4E5F6A3601D21" modified="2017-01-18" version="1">MNAVYAVTLGLLSVAALLTLVRLLRGPTVLDRILALDVLSVLLVGGVGVRAAMLGSTADVASLVVIALLGFAGTVTAARLAAERGRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C868</accession>
    <name>A0A1H6C868_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69180">
        <property type="protein sequence ID" value="SEG69180"/>
        <property type="gene ID" value="SAMN04489712_10958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="15547" checksum="10D0EA2BA879794C" modified="2017-01-18" version="1">MLYDYFAAADDGEAASVLGRRGGPDGSGFDSVVTKGIDPAVHMGTLEELLTGRPLREVFADPRSARPVGPVPRAGEPGVVTLTDSLARALATVDGAMIAETAVHWSESEEFHGEADPLDLAEFLMDLAEVARRAAGRGHRLYCRSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C943</accession>
    <name>A0A1H6C943_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane fusion protein, macrolide-specific efflux system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69413">
        <property type="protein sequence ID" value="SEG69413"/>
        <property type="gene ID" value="SAMN04489712_10981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294698" evidence="2">
        <location>
            <begin position="28"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG69413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="379" mass="36466" checksum="84FD375F42CD1AC6" modified="2017-01-18" version="1">MNGALTAVLLAAAALSYTALTGDGEQAAPARTATVSRGTLLASVSASGSVTSARTADLSFGTSGTVESIRVKVGDKVTKGQVLATLDDEAAQEAVTSAKAALDAAAEGDTATASGYSTYVSAKAEYNDALRQLSGTTMKAPFSGTITALNGTVGGPSGGSGSSGSSTSGGGQGGAGGGGSSSGSAGSGSGSGSSTGSGFLTIAATSRLEMTASFTEADIVKIKKGRPATVTFDALPDVTASGKVASIDQTSTTTDNVVQYGVRISLADPPSGLRLGQTGKVTVVTGQADDVLYVPAAAVRTAGGRSTVTVVQNGQRTTTVVETGLSGDQGVEIRSGLSEGTTVLLNTTTTGGGSGGRPQFGGGMGGGLPGGGMPGGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCH9</accession>
    <name>A0A1H6CCH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70477">
        <property type="protein sequence ID" value="SEG70477"/>
        <property type="gene ID" value="SAMN04489712_109173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="13457" checksum="428E4DD099F828FC" modified="2017-01-18" version="1">MSPLERGLTIRLLAVRVRAEAVLKAGPSGHERALAEDAVRLVEAVTNLLETRDDLRREAREQRETAARWKLRRCGRRKAAFCLGTAMAYHRAADRLNAALADALELRTGPGPGAGEPHGRSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEE3</accession>
    <name>A0A1H6CEE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein N-acetyltransferase, RimJ/RimL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71371">
        <property type="protein sequence ID" value="SEG71371"/>
        <property type="gene ID" value="SAMN04489712_109264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="174" mass="18662" checksum="572DC3259B63A14A" modified="2017-01-18" version="1">MRLRDVEPGDVDAYVRMRCDPIMMAELGGPLPRAGIEEKVRRDVAAAVADTAWVKMIVPDAGSPGEVAGTVTLWSHEADPAVGTGPISEIGWMVLPEFQGRGLGGRAVRALLTLARDDGRWGPVHAFPGAANAPSNGICRSVGFSFVGELDITFAGRTLRACHWVIDPRHEPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CK46</accession>
    <name>A0A1H6CK46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73117">
        <property type="protein sequence ID" value="SEG73117"/>
        <property type="gene ID" value="SAMN04489712_11073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="23368" checksum="C5FB1065C789D849" modified="2017-01-18" version="1">MIEQRTRIAHPATCDRETSVTRSLLGYGVIAGPVYVAVSLAQALTRDGFDLTRHSWSLLANGDLGWIHIANFMVTAAATLACAVGLRRALGPGRGGTWVPRLVAGYGVSLIAAGVFRADPAMGFPAGTPAGPGAVSWQGMLHLAAGAVGFTCLIAACFVIARRFAAGGRRGWAGYSRLTGVLFLLSFAAISTGGGASWATVTFVAGVVLAWAWLSALSLHLYRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLN6</accession>
    <name>A0A1H6CLN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_110100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73356">
        <property type="protein sequence ID" value="SEG73356"/>
        <property type="gene ID" value="SAMN04489712_110100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="377"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG73356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="572" mass="58746" checksum="0A95F748D598F724" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM54</accession>
    <name>A0A1H6CM54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74051">
        <property type="protein sequence ID" value="SEG74051"/>
        <property type="gene ID" value="SAMN04489712_110184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="16945" checksum="40DE4622C0582C3A" modified="2017-01-18" version="1">MPAGYRQVMTHTSIGPDGGEPDDATVTAVGRLSEALEMVERARGHLYSFHQLIGRADFAVEDAAELLTEAGHPGIADELLADIMGRNVLPGRWTYQVVEGFDDTYYEPFRRFERRVRNELVGGRRHPHEARLKERRRTHGRPGHEATPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRV2</accession>
    <name>A0A1H6CRV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75750">
        <property type="protein sequence ID" value="SEG75750"/>
        <property type="gene ID" value="SAMN04489712_11179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG75750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="536" mass="56975" checksum="7AEE3FB1166496ED" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSF4</accession>
    <name>A0A1H6CSF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein, DUF1330 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75583">
        <property type="protein sequence ID" value="SEG75583"/>
        <property type="gene ID" value="SAMN04489712_11159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010753">
        <property type="entry name" value="DUF1330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07045">
        <property type="entry name" value="DUF1330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1330" evidence="1">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14908" checksum="0278A4B8D62FCE70" modified="2017-01-18" version="1">MAIDPRADDLERLMTEDPGGPVVMLNLLRFAPDGQASYQEYARSTAPFLKRYGGEVLYAGQGSTALVAEAGQAWDAVLLVRYPSREAFIRMVADPEYRKVTALRRQALTEAVLQATEPWLSQSPAPDADPGNDPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSM3</accession>
    <name>A0A1H6CSM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylsulfatase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75615">
        <property type="protein sequence ID" value="SEG75615"/>
        <property type="gene ID" value="SAMN04489712_11163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG75615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="507" mass="55706" checksum="285DA9E991F9CA20" modified="2017-01-18" version="1">MINGGVGRPSETSPRSGGRRLLTRRTFLFGAATAAAVTGICGRTSRPGADDGRPNVLLVVTDDQPLGTEWATPALRELVGGQGVTFTRAYATTPLCAPSRASILSGRYAHNHGVLQNERPQRLDQGTVLPRYLREAGYRTALFGKYLNGWNVHQAPPHFDEYALMQPPKYGSAMWNVNGTVSSQSAYSTSLIRDHAVEFLRRQRRSERPWFLYVSPYAPHKPFTPEQGYAGLAVPEWNGNPAVAETDKRDKPEYVQQADTTLGEGREIRAGQLRTLRSVDDLFRALRAELLAQGQLDDTLIIVISDNGYCWADHGWGAKSVPYGPAVRIPLYMSWPAGGIAGGGVDDRLVANIDIAPTILDAVDVRHGGPLSGRGGLLDGGLDGRSLLRPQVRDRLLLEWWRAGPHQARHSWAATVTADYQYVEYYDTVLHGGVLTGTGAILYREYYDLRRDPYQLTNLLHDATPAVMDQLDTTFLSARLAADRKSGHGGGAPWRTAQGVVSRNVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUX2</accession>
    <name>A0A1H6CUX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_111185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76607">
        <property type="protein sequence ID" value="SEG76607"/>
        <property type="gene ID" value="SAMN04489712_111185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG76607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="114" mass="11890" checksum="A389039F8F953635" modified="2017-01-18" version="1">MPLVELNVSTSSRGDHAVVTATGELDLYTAPRLQTALAAVLRDQAGRVVVDLSGVEFCDSTGMNVLLAAMKRLKEQGGAFELAAPRPAVRRILQVTGLDGVFTITDALPAPGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVI8</accession>
    <name>A0A1H6CVI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77041">
        <property type="protein sequence ID" value="SEG77041"/>
        <property type="gene ID" value="SAMN04489712_111240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="28091" checksum="0D4DEB53AC2E0272" modified="2017-01-18" version="1">MADYRIDELAHEAGTTVRNIRAYQDRGLLPPPRLEGRVGYYDDSHLARLRLIGQLLARGYTFAIIKELLLAWEHGKDVSEVLGLEKVLTDPWSDEIPGQIKAEELVDVFGAGLSDAEVGAFLERAVTLGLIEPEGDHYRVPSPRLLHVGGELVAAGIPLEAVLDIAEQIRDDCEVIAGRFVGLVNEHVFDRLGADPAPGGEEPAQLAAIVRRMRPLVKMVVEPFIARAMETQTQEALGARLELIRDHLPAEAESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVK0</accession>
    <name>A0A1H6CVK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette, subfamily B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_111233</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76984">
        <property type="protein sequence ID" value="SEG76984"/>
        <property type="gene ID" value="SAMN04489712_111233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="307"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="341"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG76984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="553" mass="59384" checksum="35A259B3B141CE77" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZA3</accession>
    <name>A0A1H6CZA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78033">
        <property type="protein sequence ID" value="SEG78033"/>
        <property type="gene ID" value="SAMN04489712_11216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG78033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="866" mass="93220" checksum="0FF916309F940351" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZA4</accession>
    <name>A0A1H6CZA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78088">
        <property type="protein sequence ID" value="SEG78088"/>
        <property type="gene ID" value="SAMN04489712_11226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="49"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG78088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="474" mass="48668" checksum="154A7061CB123C05" modified="2017-01-18" version="1">MTDTYDAASESSGAQVAPPGGGTVEMAVFPKRPARTVDLDKSAPLGWWPAVVVALVAFVDRVEINLISGALPAIQDHFGFSDTAGGAIPTAASIAAALLLLPAGRLADRVPRVATIAIVVLVWSICSVLSGLATTFVMFFAVRVLIGAAGQLYNPPASSLLADYFPARSRGKAYGFERAGYYMGLPAGVILGGAVAEALGWRAVFFVAAVPGLLIAALVLTVKEPLRGLGDRLGSLRSGTAEPAGAHTPRNAGGAPLLAEARGLLRVRTLKGIIIGQALLSLAVAGLFYWLPTFLERTEDLGYDSASGLAGGVGGTGIVIGIVIGSRMGDRFHGIRHGWRIKVATGFLFLGAIALSGAVLLPGLWLRITLVAVACAGFAAAIPNLTAASADVVPADRRGLGFALLTFLVTLGGALGPFLIGLTSDIVGSTGYDGEPLALAMLVLVPAMFLAVLALLWIRNAFEHDAAQATGTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2J6</accession>
    <name>A0A1H6D2J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79500">
        <property type="protein sequence ID" value="SEG79500"/>
        <property type="gene ID" value="SAMN04489712_112225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG79500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="33793" checksum="25F01BE7E7CC905C" modified="2017-01-18" version="1">MAPEPFSLLLTVYGGDREEYVRAAFRSAVHDQQLPPDEVVLVQDGPVPAEIGVCLKELVATSPVEVKFLQLEHNRGLGPALDVGLEASSNDIVARMDADDIAMPHRFRLQVPLVRAGADLVGAGLLEFGADVDDIVGRRIPPSDPMDIARYSRIHDPFNHPTVVYRRSAVVAAGGYGDLPLMEDYWLFVRMIANGARVVNVAEPLVYYRVSDGAYERRGGRALLNSELRLQREMLRHGFITRTQYVRNVALRGGYRLVPTTIRRPFYRLLVAPYGARRNRSRDRVVATRETAHPNAQAEAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D627</accession>
    <name>A0A1H6D627_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-L-rhamnosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80205">
        <property type="protein sequence ID" value="SEG80205"/>
        <property type="gene ID" value="SAMN04489712_11339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295549" evidence="1">
        <location>
            <begin position="32"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="2">
        <location>
            <begin position="250"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="3">
        <location>
            <begin position="567"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG80205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="684" mass="73853" checksum="F853B9C5B239F2CF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6K1</accession>
    <name>A0A1H6D6K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-rhamnose mutarotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80236">
        <property type="protein sequence ID" value="SEG80236"/>
        <property type="gene ID" value="SAMN04489712_11346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="105" mass="12461" checksum="332B23343CB83037" modified="2017-01-18" version="1">MRRVCFLLKVRQDRIEEYRERHAQVWPDMQAALRDTGWHNYSLFLRDDGLLVGYLETDDFQAALDGMARTEVNARWQAEMAPFFENLDGRPDEGMRPLTEVFHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8Z3</accession>
    <name>A0A1H6D8Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81689">
        <property type="protein sequence ID" value="SEG81689"/>
        <property type="gene ID" value="SAMN04489712_114119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="105" mass="10685" checksum="4553D92953AA5B46" modified="2017-01-18" version="1">MGEQGQRGATAPLVLHILIVTVYEGIILMAFSSTRSPVRRRSARVLAVGALAIPVVAVTTPTATAAPHVVDPVALLTCVSESASLNVDPAGLSAELPLTSCLTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9L6</accession>
    <name>A0A1H6D9L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase YjhB, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81513">
        <property type="protein sequence ID" value="SEG81513"/>
        <property type="gene ID" value="SAMN04489712_11474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="17855" checksum="DA17A402C0C96777" modified="2017-01-18" version="1">MPDVAYYASLPRTRGAAAALLLDDLGRVLLVKPTYKEGWFLPGGVIEHGESPLAACLRECQEELGFTPRLDGLACVDWGPPQEGIDAVNVFVFGGSVTAEEITGIRLPADELSDHTLVSPEKIPELAAPHIARRMEPSLRGIAEGRAIYLENGHEPSFGPGLRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9R7</accession>
    <name>A0A1H6D9R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81824">
        <property type="protein sequence ID" value="SEG81824"/>
        <property type="gene ID" value="SAMN04489712_114152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="90" mass="9591" checksum="E81C8DD180118FC8" modified="2017-01-18" version="1">MVEPLGSLGESATLGELRAMCAAMLPRVDPPELLLEVHSWTGFLDAYTHLADISTRMTGLPRSWLERGCKDARAFGSGVGGVAVLGGFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAD4</accession>
    <name>A0A1H6DAD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81665">
        <property type="protein sequence ID" value="SEG81665"/>
        <property type="gene ID" value="SAMN04489712_114112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="30642" checksum="F2D2F1A6BD0BE6E5" modified="2017-01-18" version="1">MSRRLARLGVRLHPDKAAFRVHDRGADPAGLQAPAPPQNGELVSVGYDQMWVASLQDDVEVTVLLEEWDGEPPSGRGAWEQESSGEIYLRGAVAVSTATAEPVVHGVRLLGGVGRYRMRIRAQHRAAIAGLYDALLDRFRDGFSLEFQAALRELQGVEHYLIQLWPSPTASGPQRVVSEAALALSGAFPPAAGLEPPDQTGPLPSLPARPPSPPGPAALPPAAGPLPSPAVPQETPQESPRDAPGVGSSAEQAVNGPPAEPPRPVAPSAEPQTPAASASAAPAGEAGAAEGEPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DB97</accession>
    <name>A0A1H6DB97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82432">
        <property type="protein sequence ID" value="SEG82432"/>
        <property type="gene ID" value="SAMN04489712_11525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="406"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="616" mass="67030" checksum="8EC41A6865949A99" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBF7</accession>
    <name>A0A1H6DBF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82474">
        <property type="protein sequence ID" value="SEG82474"/>
        <property type="gene ID" value="SAMN04489712_11531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295709" evidence="1">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="11194" checksum="BD8CF527248FD1B1" modified="2017-01-18" version="1">MSRENSSRRIRRAAALAVIGAVAGLGTAVVGVLPAEAACRYSYLAGGAEYGAYAYAETADCAWISRSYARHGNVATLSGWYPVSSFARVDIGYHPSWEARNEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBK8</accession>
    <name>A0A1H6DBK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82711">
        <property type="protein sequence ID" value="SEG82711"/>
        <property type="gene ID" value="SAMN04489712_11569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="16653" checksum="CAF961789DF144F2" modified="2017-01-18" version="1">MMVTMSALKGKLEADLSAAMKARDEVRTRTLRMALTAVRNEEVAGKQARELGDDEIIKVLTREAKKRREAAEAFADAGREEQAQAERDESAVLADYLPAQLSDEELAAIVTAAITETGASGPKAMGQVMKVVNPKVAGRAEGSRVAAEVKRRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFE2</accession>
    <name>A0A1H6DFE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_116109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83950">
        <property type="protein sequence ID" value="SEG83950"/>
        <property type="gene ID" value="SAMN04489712_116109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39186">
        <property type="entry name" value="PTHR39186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="28168" checksum="42E01A9CB56FF907" modified="2017-01-18" version="1">MHAASPAPEPVTADAPGAITNPLLTQSWLDLAFVHWAVDPQDVEPLLPAGAVPDTLDGVTYVGLVAFRMHRVGWFRLPGLPYLGTFPETNVRLYSVDGHGRRGVVFRSLDASRLVPVIMARAGFRLPYLWSRMTVRADGDVIRYTSSRRWPGPRGAHSRIAVRRGEPIEEPTELEHFLTARWGLHNAFLGRLMYLPNVHPRWPLHRATLLYCDQDLTTAAGLPEHLGEPVSVLYSPGVPVRFSRPARPAGISTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKR2</accession>
    <name>A0A1H6DKR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_117158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85185">
        <property type="protein sequence ID" value="SEG85185"/>
        <property type="gene ID" value="SAMN04489712_117158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="23002" checksum="72EA3D2527B96B89" modified="2017-01-18" version="1" fragment="single">NGKHFSAGHDLKSGAPAPEKLTLEWIYTIEARRYLEYCLRWRNVPKPSIASVQGKCIAGGLMLCWPCDLIVAADNAEFSDPVVHMGIGGVEYHGHTWELGARKAKEILFTGRAITAAEAAQIGMVNRVVPLDELQGATMELAGQIARMHPFALRQAKRAVNQTLDVQGFYAAVQSVFDTHQTGHGNALSVDGYPILVQYDEMKKRLKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMY6</accession>
    <name>A0A1H6DMY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86652">
        <property type="protein sequence ID" value="SEG86652"/>
        <property type="gene ID" value="SAMN04489712_119137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="199" mass="21424" checksum="95047A4DB977A507" modified="2017-01-18" version="1">MQASTTGRVLHDPKGGSFRFDAGAVCLDFAHTGGAGRYAVFETLHEPADLAEWLAQPPLAAVMTVPVTTRELAAAKALRQAVWDTAHARAAHRPLPAEAIATINQAAAKAPLTPELAADGTTARWATPVRASQALSALAREMIELLSGPLSERIRECASDNCPLVFVDTSRPGTRRWCTMERCGNRHKLRALRARRADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNW8</accession>
    <name>A0A1H6DNW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86473">
        <property type="protein sequence ID" value="SEG86473"/>
        <property type="gene ID" value="SAMN04489712_11992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="973" mass="104466" checksum="EDE0D9D3EAAF3867" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP63</accession>
    <name>A0A1H6DP63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">smc</name>
        <name evidence="8" type="ORF">SAMN04489712_12066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87089">
        <property type="protein sequence ID" value="SEG87089"/>
        <property type="gene ID" value="SAMN04489712_12066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="7">
        <location>
            <begin position="528"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="411"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="669"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="850"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1028"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG87089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1218" mass="131352" checksum="698001BB291AB6C0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQA8</accession>
    <name>A0A1H6DQA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_120140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87478">
        <property type="protein sequence ID" value="SEG87478"/>
        <property type="gene ID" value="SAMN04489712_120140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="31998" checksum="D858E99FE48C4F4A" modified="2017-01-18" version="1">MASTRYREIADSLRKRIQDGEWAPGETLPRHADLAQEYGASRNAVARAISVLEDEGRLWAVPRRGTIVRSDKRRVIMRTNLVRRNTRHVVDGKPTAGGYSFPAAQGDELWVHHAEPTVTEEPMTDARLAHMLNVKVGAAICRRRRVTGPPDEPPFQISTTWIHPRGVADAPLVKEPYGTGPGAWIDRLEEAGHGPIEWLERRRARMPDQQEATLLQIPVSLPVWEIVRIGYSAKDDNALEVTQVVIPSDRMEEVSRLERDESAKWPHPDNGPDGPPIAGRRRSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DS90</accession>
    <name>A0A1H6DS90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88139">
        <property type="protein sequence ID" value="SEG88139"/>
        <property type="gene ID" value="SAMN04489712_12184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="21084" checksum="8E8CA4D191A4CB12" modified="2017-01-18" version="1">MVHRKQRAGTARERLLTVALDLFAQHGVSGTSLQMIADELGVTKAAVYHQFRTKDDLVWAVIAPALDRLAHITETAEGRRRRSERVETVLSGLVDLVVDNRRLTSVLQSDPAIIRLVRGHPTLQAIEERITRLLAGPEPDPEALVNAAMVSGLLIMGTDPRLAGLDDGTLRRHLLGTARRILRLRAPASAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSI0</accession>
    <name>A0A1H6DSI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88198">
        <property type="protein sequence ID" value="SEG88198"/>
        <property type="gene ID" value="SAMN04489712_12196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="25383" checksum="E225BAA5289EC59D" modified="2017-01-18" version="1">MTEVSEEPAWRQRAVERSTRAAKLRAEQRVQRFLDSAQELIAEKGTTDFTVQEVVDRSKQSLRSFYQHFDGKHELLLALFEDALSKGAAEIRQAAYAKRDPMQRLRVAVEMLYEQSRPNPEVQRPLFNDFALQLLVKHPTEVATAHLPLLTLFSEFIEQAAEAGAVPEGKTRRRASLVMQTVMFTAYTSSVPGGQASPVTSEEVWQFCLGGLCGSPAKPRTSRTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DV20</accession>
    <name>A0A1H6DV20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89118">
        <property type="protein sequence ID" value="SEG89118"/>
        <property type="gene ID" value="SAMN04489712_12324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="DUF5519"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="DUF5519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="161" mass="16403" checksum="157ECA4C912AEB4D" modified="2017-01-18" version="1">MNDVAALGSGASSFADRLVKRLNTWPAVSIGRADCGIGFGLGVGPRQILHLHSADLHSADEAELLLTRPVIERLGAALARSGRVAVRPGGDWVRIGLSTDSDVTLVLSLASVAIKAAGDPVGTSQATPCSAAERPAAEQTAPRPGRDPGPAALSGNGPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXE1</accession>
    <name>A0A1H6DXE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89386">
        <property type="protein sequence ID" value="SEG89386"/>
        <property type="gene ID" value="SAMN04489712_12381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="4">
        <location>
            <begin position="56"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG89386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="17259" checksum="D3DAFD9C190F9BC5" modified="2017-01-18" version="1">MIDDRKAPQVPRSRRPQHHGPRSSAAVPRCRQGAGALSPADGEAELTVTVAGAHGGTLVAAVTGEIDLRTAEELRARLIELGEELTAAGQGRLVLNFGGVGFCDATGLGALVGAHNHLHARGGEISLAAVRPSQRRLFRITGLEQVFPLYDTVAQAVAAGRTSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ80</accession>
    <name>A0A1H6DZ80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potA</name>
        <name evidence="10" type="ORF">SAMN04489712_12545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90123">
        <property type="protein sequence ID" value="SEG90123"/>
        <property type="gene ID" value="SAMN04489712_12545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015417">
        <property type="term" value="F:ABC-type polyamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="18"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG90123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="366" mass="39924" checksum="FCFE223BCC0D1756" modified="2017-01-18" version="1">MTAALETTSTQTSTGAPISINAVSKKYGDNTVLESVDLDIRAGEFLTLLGASGSGKSTLLNIIAGFTRPTAGTVKVDGRDITSLPPHKRGFGMVFQHYALFPHMSVADNVAFPLKRQKVAKAEIQQRVAETLELVELGHLGGRRPSELSGGQQQRVALARAIVFRPRVLLMDEPLGALDKLLREQLQLEIRRLHQEMGITFVFVTHDQDEALTMSDRIALLRNGRIVQLGTPEQLYAEPNCRYSAEFVGASNIFTGTVQGRSFIDDVSGQSYRLGEAADQSGRSLLVRPEHLNIAPADVPVPDTVEQVEAIVEDCIYLGSSRTVQLRTDAGQRLVARTNVPRTPDGVVSGARVHAYWDVRDACVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZE2</accession>
    <name>A0A1H6DZE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TadE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90728">
        <property type="protein sequence ID" value="SEG90728"/>
        <property type="gene ID" value="SAMN04489712_12721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="14208" checksum="37615DC65308681C" modified="2017-01-18" version="1">MSLELVLMTPVFVMFIMLLAAVGRYVDAQSQIDGAARDAVRAASIARSAGDAVRYADRAGAASLNGHHWCRGGPSIVTDTGNWGPGGRVTVTVTCTVGLGDLAFLGLPGSRTFTGSAVAPIDTYSYRGTDSPAEDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZF4</accession>
    <name>A0A1H6DZF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional hydroxylase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90334">
        <property type="protein sequence ID" value="SEG90334"/>
        <property type="gene ID" value="SAMN04489712_1265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="486" mass="51632" checksum="68087CFCA7FB12E9" modified="2017-01-18" version="1">MDASVIVIGAGPTGLMLAGELRLAGTDVIVLDRLGARSGQSRAIGFTIRTMEVLDQRGLLPRFGGIETVYAGHFGGLPLDLGLLDSTHGAAHNVPQNITEAVLEGWARQLGADIRRGQEFTGFVEDGTGVTVTLRDGPALRCRYLVGCDGGRSTVRRIGGFDFPGTSATTELFLADIRGLELAPRTAGAQTPNGMAMVARLSDGVHRIVVAERGIPPRDRTGPPEFAEVADVWKRVAGSDISTAKPVWVSAFGDAARQVTEYRRGRVLLAGDAAHIHLPAGGQGMNTGLQDAVNLGWKLAAVVRGRAPGTLLDTYHDERHEVGRALLANTRAQGALLLGGNDAVPLRDVLGDLLGSAEAQRLLGARVSGLDITYDMGRGRHPLLGARMPLIRLDRAGRGTGSAELLHTGRGVLLDLADNRTLRRRARPWRDRIDIVTATPRGNDAADALADTTALLLRPDGHVAWAAPGTDDDLRTALDRWFGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0G2</accession>
    <name>A0A1H6E0G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91062">
        <property type="protein sequence ID" value="SEG91062"/>
        <property type="gene ID" value="SAMN04489712_12826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="127" mass="13234" checksum="63441F74AEEE5052" modified="2017-01-18" version="1">MRNIPVDTSALTFVCVSPPRPKLINQDTGEVKVDRNGQTVYTVGLSAADESGRVELVNVAVSGDPGVVIGQVVTPVGLVGFPWEQHINGRMRWGIAYRAEQIIPAVQTAPASVGSVGSAVPVSADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3A7</accession>
    <name>A0A1H6E3A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92112">
        <property type="protein sequence ID" value="SEG92112"/>
        <property type="gene ID" value="SAMN04489712_13228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="32605" checksum="374A6DEB0CFF95BC" modified="2017-01-18" version="1">MVTPAFTPTTQERVVTPTFRALGMRRPHRPPRPGTRRPPRHLPHRLLLHHRPRRDVLPERRMLPRRRPRPSRLHLRLRDGTRRPALRLRVRPQHHRSPDQQPGDGQGPDEQRRPPRGREPSLIHTFRMPTCHGTEAYRRPSSRNSLRPHLRHPAAVTGHMTPRSPAAGPQPSPPAPVRPCDRSQSSDSAPDPPVLVRCRAHDCRKFRARGHATAGTHARSPCPPDAESPPKSSRAPRTRASRQCDGSPPAPGHSPRARTARVPGPDPHGRWKHRWPGPSGTGLSERTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3R9</accession>
    <name>A0A1H6E3R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase DDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91694">
        <property type="protein sequence ID" value="SEG91694"/>
        <property type="gene ID" value="SAMN04489712_13023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="21656" checksum="552C4280EE216510" modified="2017-01-18" version="1">MVDPLGLLPAAEVTAASVQDSIAGTALIDQIATDHPSLRTTWVDGGYRRHLVEHAATLGIDMQIVQRPPGTRGFTPLPPRWVAERTLGWLMLHRRPVRDYETLPASSQAMIHIAMIDLMSRRLTGEATPTWRGTRPGTKQKPRDETSTRDVSSSWISSTTRTWWEGARRTERQARRAVRPSRVMVPSSSRTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5T1</accession>
    <name>A0A1H6E5T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92559">
        <property type="protein sequence ID" value="SEG92559"/>
        <property type="gene ID" value="SAMN04489712_13434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="213" mass="22207" checksum="C52EF268E745BDC7" modified="2017-01-18" version="1">MRKPAKPAKPAKHAKPAKRVELKPTGRVALTGLAGAVLVTGITVGTITKLTAEPAAAEQIPAAAARQEAGAPTTVESKAAAPRALLTGYTTASYFWDDGSGIRGDTGAPASGKPMQKGMFASPSWPLLTKVKVTYNGRSVVGFVGDRGPGEPSHRGIMLDLDTYSFRYLHDGGRPASKYHAGTDVGHLKGVKYEVLEWGSGRGEKGAPKPFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E614</accession>
    <name>A0A1H6E614_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92406">
        <property type="protein sequence ID" value="SEG92406"/>
        <property type="gene ID" value="SAMN04489712_13345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="22581" checksum="6B4F455E56B86999" modified="2017-01-18" version="1">MTTSTRERIVTESLRLFADRGYAATSVAEIEAAAGLSPGAGGLYRHFRSKEEVLAAAVREHITRTREQIASVMEIAGDFAGRPLEVRLKMACKAGLAKMREEQDLIRVLFRDLDQFPHLVAEMREGIVNPLYDSIATWLGSQPEYDDADEDWPAIASVLGGAVVNYWLSNESLYESPTRVDETRFVDGWVRLALGLVAAEHSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6C3</accession>
    <name>A0A1H6E6C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kynurenine formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92803">
        <property type="protein sequence ID" value="SEG92803"/>
        <property type="gene ID" value="SAMN04489712_13535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="29341" checksum="14AF3A04B245D332" modified="2017-01-18" version="1">MLEETQAALGALLGRSVQAFDLSQPLENGMPCSPSHPGFHMALMRRHGDLMRGAGSGSNEIITFGGHVGTHVDALAHVAAHGQLHGGIDAVANSVGGRHRQLGAETIPPTLCRGRLLDIPRVLGQGRLLAGYGVTVDDLQAAAGTTPIEPGDVVLVRTGWPQVYHESETYIGHREGAPGVTGPAAEWLANHGVRAVGSDTIAFDQILPGLGHSQMPAHHILLVQRGIHIIEVLNLEELAEHGAAEFWFLMIPLRLVGATGSPVRPLAIVDPTSLETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9R3</accession>
    <name>A0A1H6E9R3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93666">
        <property type="protein sequence ID" value="SEG93666"/>
        <property type="gene ID" value="SAMN04489712_1408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG93666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="28460" checksum="A179EE7BF8BAF58C" modified="2017-01-18" version="1">MEPKNAGDWIGRFLGERTVTWTERDAILYALAVGARATELDLVYEERLRPLPTFGLTLAQWGPDALGGAGAFDTARGLHGAQHLEVLAPLPPRGELTMSACVEAVWDKGSAAVFEVRVDSECFVARWSIFAPGAGGFGGERGPSGRRAAEWTASRTTTVETFTEQAALYRLCGDQHAIHIDPAAARAIGQERPILHGLCTMATSLLVLARTIGAHPADLREAGCRFTAPVVPGDVLELKAHVSGGTAAFEVCKDATPVIGSGLARFGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBN1</accession>
    <name>A0A1H6EBN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000044">
        <property type="protein sequence ID" value="SEG94205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94205">
        <property type="protein sequence ID" value="SEG94205"/>
        <property type="gene ID" value="SAMN04489712_1447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="897"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="968" mass="102684" checksum="13346C346AC6025B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EC69</accession>
    <name>A0A1H6EC69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_14910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000049">
        <property type="protein sequence ID" value="SEG94629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94629">
        <property type="protein sequence ID" value="SEG94629"/>
        <property type="gene ID" value="SAMN04489712_14910"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="11">
        <location>
            <begin position="25"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG94629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="565" mass="63197" checksum="0621B9CD0ACE1B5D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ED14</accession>
    <name>A0A1H6ED14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_15010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94695">
        <property type="protein sequence ID" value="SEG94695"/>
        <property type="gene ID" value="SAMN04489712_15010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="51" mass="5306" checksum="842BFCB4303BE74E" modified="2017-01-18" version="1">MFVRRCGFIAFWLVLTLYVLRHPLGAAQTVAAIGSGLAALADALAAFASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ED47</accession>
    <name>A0A1H6ED47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000074">
        <property type="protein sequence ID" value="SEG95203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95203">
        <property type="protein sequence ID" value="SEG95203"/>
        <property type="gene ID" value="SAMN04489712_1742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG95203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="29" mass="3242" checksum="79BD985C45AB6E0E" modified="2017-01-18" version="1" fragment="single">WRALRHVTLSPGRIGAITQAALVLNNAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S5A0</accession>
    <name>A0A1H5S5A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane associated serine protease, rhomboid family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45823">
        <property type="protein sequence ID" value="SEF45823"/>
        <property type="gene ID" value="SAMN04489712_10187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="90"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF45823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="26828" checksum="3B10F3DD615E218B" modified="2017-01-18" version="1">MALPLYDSQPARRAPVVTYLLVAVNVVIFLLTPMANFAASYGEGRTRECNAVEFTLEHGAIPKELTTGRQQPAPERVGPCAVEPYHKVPWVSAFTSMFLHGDWLHLTGNVVMLFVLGAGVEDRLGRLRYLLSYLLFGLVAVYGFAFASPGSTVPLIGASGAIAGVLGAYLILNPRGRIVSYVPPVIFSRLPAWVVLGLWFVLQWLSLGDEDSNVAYVAHIYGFVTGVLFALLARRAGPARRAVALAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SB15</accession>
    <name>A0A1H5SB15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent Zn proteases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47011">
        <property type="protein sequence ID" value="SEF47011"/>
        <property type="gene ID" value="SAMN04489712_101119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="310"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF47011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="870" mass="95493" checksum="58C1173B810DCF3E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SDQ4</accession>
    <name>A0A1H5SDQ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="12" type="ORF">SAMN04489712_101165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48625">
        <property type="protein sequence ID" value="SEF48625"/>
        <property type="gene ID" value="SAMN04489712_101165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="11">
        <location>
            <begin position="41"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF48625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="24125" checksum="5A1CCACC7E88AC2D" modified="2017-01-18" version="1">MTVAAASGVPASAGGRNGSTPPRPGAAQAPGGDVPPDLHRRRLTVLSGPSGVGKSTVVAEIRQAHPEVWLSVSVTTRPPRPGEQHGVQYFFVDDAGFDRLVEEGELLEWAEFAGNRYGTPRAPVVERLAAGVPVLLEIDLQGARQVRRAMPEARLVFLAPPSWEELVRRLVGRGTEPPEVIERRLAAARVELAAEKEFDVTLVNTAVRDVCRELLALMADHPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SES2</accession>
    <name>A0A1H5SES2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized membrane protein YphA, DoxX/SURF4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49092">
        <property type="protein sequence ID" value="SEF49092"/>
        <property type="gene ID" value="SAMN04489712_101180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF49092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14403" checksum="A70E28633CF4D9FC" modified="2017-01-18" version="1">MDVIALIGRILFAAIFVGSAIGHLTATDAMAGYAASKRLPQPHLAVRVSGVYLLVAAVMLVLGIWPDLAALALVPFLLITAFVFHDFWSVPDPATRRQEQVQFLKDVSLAGGALALFVLYASAHHPGANLVGPLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SNB6</accession>
    <name>A0A1H5SNB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative spermidine/putrescine transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51944">
        <property type="protein sequence ID" value="SEF51944"/>
        <property type="gene ID" value="SAMN04489712_101285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF51944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="383" mass="41427" checksum="8F577220DAA9A631" modified="2017-01-18" version="1">MPASRGLAQTPDTERAGRAGRGAEIALDRLTKRYGDFVAVDEVSLTIEPGEFMTLLGPSGSGKTTTLNAIAGFVTPTSGSLRMDGTAIESAPPHKRDIGMVFQHYALFPHMTVAENIAYPLRRRKIAKDRRRELVAAALETVRLGEYGHRYPRELSGGQQQRVAVARAIVYGPRVLLMDEPLGALDKKLRDWLQLEIKRIHAELGTTFVYVTHDQDEALVLSDRIAVFNNGRIEQVGSAHALYERPETLFVAKFLGESTVLRGAAEAGAGRSALGKAGRTLTAAGELTGAAAIVIRPERLVVVGAGERAEPGWNALPATVLQEIYLGSSRKLELRLPDGDTALVREAAGRLSAARPGDEVTLTWRVEDAVLLPDDPDVETVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T1E3</accession>
    <name>A0A1H5T1E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56610">
        <property type="protein sequence ID" value="SEF56610"/>
        <property type="gene ID" value="SAMN04489712_101444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF56610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="242" mass="27370" checksum="1EF2D21E7CAAE9CB" modified="2017-01-18" version="1">MNDKVYIHEFIDITKQNRARYMHHMTANWSPIGQEQRGQLCYGVWGVVGSTGRWPQVVNIWEENGFAGLASSFRHELGNATLQDPALEKWWAAAADLRSGGVDRIIVPHPGTPTIEQVCREGIRGEVYAHELIEVGPGGARRFLDAAVEEAAKDRPGHRWRLVGAWTTAMRNDSECLLLWAIPTWEAWADVERDEAAGRRRILEAVTPLIRGRERILLADSPLCPFRTGRQPSRADRTDWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T642</accession>
    <name>A0A1H5T642_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58256">
        <property type="protein sequence ID" value="SEF58256"/>
        <property type="gene ID" value="SAMN04489712_101498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284732" evidence="2">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF58256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="79" mass="8201" checksum="480039330873CF3A" modified="2017-01-18" version="1">MRASGTAGLVAALVVVGVLTSGCGNGNTATEDRRTFIDRHGRVCTYIFITESEGDSVDSDVSDLECDFPPPPPTPSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T6X1</accession>
    <name>A0A1H5T6X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58529">
        <property type="protein sequence ID" value="SEF58529"/>
        <property type="gene ID" value="SAMN04489712_101506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="264"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF58529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="39529" checksum="228AB65390F98653" modified="2017-01-18" version="1">MTDAVIVSAARTPIGRAHKGSLVDVDAFRLARVAVGAAVDRSGVPVTDIDDLVLAESLQGGGVIGRYVAVESGLAHVPGLADNRHCAAGLSAIQIAAGSIRAGMDRVVVAGGTESLSSMPRVSKSIPASARDLRPWMSPSHPETPQAPAFDMPLTVGENTARLAGVGRAEADEWALRSHRRAAASVAAGHFADEIVPVELPDGRLFDTDEHPRADTTAERLAQLPVLHPELDGAVITAGNSAGLNDAAAAVVLTAGDYARANGLTPLARVVAWASVGVQPERTGLAPTLAVPKALDRAGLKIADIDLYEINEAFTTVAAASARILGIDPDALNVNGSGCGLGHPIAATGARMVVTMLGELRRRGGTFGCVSMCAGGGMGSALVLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TCP7</accession>
    <name>A0A1H5TCP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR C-terminal helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60540">
        <property type="protein sequence ID" value="SEF60540"/>
        <property type="gene ID" value="SAMN04489712_101567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="311"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF60540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="377" mass="40195" checksum="A6B43A8EF4C1FAC3" modified="2017-01-18" version="1">MDPERAAGFWELLHEQARDPALLEATVRAARSRSPLVAELPEEETRRHTRALVEGAIDALAKGGEPGEEALRAAERLGSDRARQGVPVAALLDGFQAGRSHLVRALIDEGLTRGIPAEVLLKGVTRIDAITTALVHRMVHAHRVTELELARTTREGHVQMLRQLLHGEPVAVPAPLDPSVPYHCVVSDISDPALAQRLEPVLCGPAKAGLSGLVDGRLAALVPRLPGPSALPAGTPLLVASPAARPADVAELYQLALRALRAALPHGLDGLHHLTGLALMAATAAEPVLGRLLAGDLLAGLVPGDPFHRELAETALAYLDHGGRIEPTAAAVHVHPNTVKYRLRRLQDLTGRPLVAEGGNAVSHSAHWWWALHAWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TD49</accession>
    <name>A0A1H5TD49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60765">
        <property type="protein sequence ID" value="SEF60765"/>
        <property type="gene ID" value="SAMN04489712_101574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF60765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="22438" checksum="38C4ACA839F40FAB" modified="2017-01-18" version="1">MPTPPWRRPEAQQGGDRAANGNAPDENPLDGRAGGERTAEQRTDEREERARAAGTGEADVTDVRVAGPPPAPVRQTGEFRQQPRTPEAEGEAANSTPANSTPAASAPATAPVPRQAQPHDEPPERFMDQDTAARLRERWHEVQAGFVDDPHEAVRKADEMASQALTALGESLRERWQAVEGGGDTEQLRLALRRYRDFLDHMLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TGH0</accession>
    <name>A0A1H5TGH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61864">
        <property type="protein sequence ID" value="SEF61864"/>
        <property type="gene ID" value="SAMN04489712_101609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF61864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="15641" checksum="534EF88BFE37255C" modified="2017-01-18" version="1">MPMSYASAVINASAEEVWAYLRDGGNLAEWRPGIATCAIEDGGPADRVGSVRRLIGVGDSVFRERLTLLDDAARCCSYDILDCPLPVRDCRATIRVAPVTDTGQAFVEWRAEFAADAADERAMAVTFDRAVLGSGLDLLRRRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TSI3</accession>
    <name>A0A1H5TSI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phenylpropionate dioxygenase, large terminal subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65710">
        <property type="protein sequence ID" value="SEF65710"/>
        <property type="gene ID" value="SAMN04489712_101729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="67"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF65710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="399" mass="43495" checksum="018935D897EF0C42" modified="2017-01-18" version="1">MLMEELIGELGRYLGDAGSDAGSDAGSDAGSDAGSDAGTPAIGLPPHAYTHPGFYELERSQIFGRSWVLVGHASRLAEPGDYLALTVAGEPVLVTRGRDGALHAMAPICRHRNMPLVEPGTGRANAFTCRYHLWRYGLDGRLLGATFMRENAAFDPAACRLPAFAVEEWHGFVFVNLDPDAEPLTPHLGRAEEETADYGLDSMVQVASWREEWRVNWKLAVENAHENYHVMGLHPTTVALITPRGGGDMDVRADSPWATRLRSPFKEPMPPGVLPLRDEQRAFMDNYCVFPSGSIATFADSIVWISFVPLSIDRTEVRGGVLLPPALLDGADAEALRKEHEASAATVNDEDRDGLEAVQRTIGSRFTGRGHLSPKEPGVLAFYRGLARALTRPRGEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TV49</accession>
    <name>A0A1H5TV49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66674">
        <property type="protein sequence ID" value="SEF66674"/>
        <property type="gene ID" value="SAMN04489712_101758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="43"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF66674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="247" mass="27448" checksum="982B17858F6EAB2E" modified="2017-01-18" version="1">MFDADLAEVYDLVYRGRGQDFRAEAELVTRVVRTRRPGAVSLLDVGCGTGEHLSALRACFDHVEGLDRSESMIAVARAKLPGVRVHAGDMCDFDLGRRYDAVISLSSAVAYLPSAQAMRTAVARMAAHLVPGGVLVVEPWYFPEAYVEGHIAGDVLRENGRTVSRVSRAERDGEFVRVDSHYLVADRQSIRHFTERQTFGLWRRELYERALRDAGCSTEYIEGVQSRRGLFIGRLTRRAVAPHAGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U0J0</accession>
    <name>A0A1H5U0J0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Ribulokinase</fullName>
            <ecNumber evidence="3 4">2.7.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">araB</name>
        <name evidence="7" type="ORF">SAMN04489712_101799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17601"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17173"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:22072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58226"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the ribulokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.16" evidence="3 4"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67948">
        <property type="protein sequence ID" value="SEF67948"/>
        <property type="gene ID" value="SAMN04489712_101799"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008741">
        <property type="term" value="F:ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00520">
        <property type="entry name" value="Ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005929">
        <property type="entry name" value="Ribulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01234">
        <property type="entry name" value="L-ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="6">
        <location>
            <begin position="286"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF67948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="549" mass="57990" checksum="AD73BEF509B932AC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UX07</accession>
    <name>A0A1H5UX07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79500">
        <property type="protein sequence ID" value="SEF79500"/>
        <property type="gene ID" value="SAMN04489712_10267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF79500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="511" mass="52514" checksum="AE1AD943A89916E8" modified="2017-01-18" version="1">MNQQSGELAQEGRIGPYRSLARLGEDGTGTLYRGTDPLGRDVAIKVLRPEVAGDPAARRRLDREIEMLRRVLSPHVVDVLDGDATGDRPYVVTRFVPGRSLDRLVAERGPLRGGALRRLALGLAKALTAVHEAGVVHRDLRPGTVLMVGGEPVVIDFGVSDRPVGADGTRTVPGPAGADGRLVLEPGSGLAPELLDSGPATPASDVYAWATTVAFAATGRTPSGQAAFGDARDGWVRPDGMPEPLLPLLRAALEHDPAARPTAAELVTAVTALDLGPEDLSVAVPGPVPADSFGQEADTATGPSPARPRPVQVGPRPRLAVGTAWSRLLAVLTVVLVAGVTIMMPVAGLVAAVLGALALRVWDSAAARASGGTGTGRVSPAPADVARAVLRTALTLPYAAVVTVVVTVVLASLVVLEVRTTALEAAAWGAGAGAAVLWTGPGVRAPRRQLERLFEALAPEPGRIVLLGAVLGALAFVSVIGAVSLTPSFAPMYGLQNSVASALDRLQNVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VBR9</accession>
    <name>A0A1H5VBR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty-acyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84802">
        <property type="protein sequence ID" value="SEF84802"/>
        <property type="gene ID" value="SAMN04489712_102256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="55"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="442"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF84802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="528" mass="55963" checksum="4F84D3C99337448E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VU43</accession>
    <name>A0A1H5VU43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_102460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90750">
        <property type="protein sequence ID" value="SEF90750"/>
        <property type="gene ID" value="SAMN04489712_102460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF90750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="10986" checksum="B18D81BC6C3FA463" modified="2017-01-18" version="1">MDVVRAFRVVSLLEATSFLLLLVASVLKRTADFPEGVTVLGPIHGALFVAYVAVAFMSRSQTGWSNGRMALALGASVLPVAPFFVERKWLRPIEKTPAARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VZ83</accession>
    <name>A0A1H5VZ83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92574">
        <property type="protein sequence ID" value="SEF92574"/>
        <property type="gene ID" value="SAMN04489712_102529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF92574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="69" mass="7512" checksum="FBD97CBA4F1BC2AF" modified="2017-01-18" version="1">MSGRDGAGPAVGEVGVQVLYLRAVIRVYGPWTTSQTISADERALAVRRVRYAGDLLADLEAQLPRNEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WYI5</accession>
    <name>A0A1H5WYI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04373">
        <property type="protein sequence ID" value="SEG04373"/>
        <property type="gene ID" value="SAMN04489712_10310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="132"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="194"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG04373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="423" mass="46001" checksum="9B1727BA2E41A22E" modified="2017-01-18" version="1">MNDGLWRRLRPTIRVRLTLWYGGLFLAAGVVLLGVTYMLVAQNLHGQQTIATKVMAPDIKIMQVPSSPDAAARTGPDASAADPEPDQRFRKLLINAEQDYRQATLNALVTQGGIGLALVSTVAVGLGWLMADRALRPVHRVTETARRVAQSHNLTERIAYDGPRDDVKELADTFDVMLARLARAFEAQRRFVDNASHELRTPLAINRTLVDVAVRRPDATEDVRRLGESLLVVNARHERLIDGLLTLAGSENAVTDRTPLDLADVAGHVLDLAEVEAAERGVTVHRALGQAPTAGDPVLLERLVQNLVENAVRHNAAKGGELWLATRWWPHFTELVVANTGPVVPPYEIETIFEPFRRLRGDRVRSDRGAGLGLSIVRAIATAHGGHVTALPREGGGLTVTVRLPGRQPAGPHPGARSGAREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WYX7</accession>
    <name>A0A1H5WYX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04859">
        <property type="protein sequence ID" value="SEG04859"/>
        <property type="gene ID" value="SAMN04489712_10325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG04859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="22856" checksum="922D33DF203DB787" modified="2017-01-18" version="1">MAGGGRPAGARTSRVERRILAAAVRLFAERGFDGTSVQQIVDRAEITKGGLYHYFDSKQDLLHEIYRSLITRQLADLERILAAGLDPPATVRAVIGELVTSTAEHIDEAQVFSREMHRLDRTRMAAVRADRRRYHVAFREIVERGQREGVFAPVAPADTVTLVVFGMVNEMPRWYRADGPKSAARFAAEVADFVLAALEPRRDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X5P5</accession>
    <name>A0A1H5X5P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-deoxyglucuronate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06775">
        <property type="protein sequence ID" value="SEG06775"/>
        <property type="gene ID" value="SAMN04489712_10388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024203">
        <property type="entry name" value="Deoxy-glucuronate_isom_IolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39193">
        <property type="entry name" value="PTHR39193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036628">
        <property type="entry name" value="IolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04378">
        <property type="entry name" value="myo_inos_iolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG06775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="28391" checksum="911E1E641DA9E071" modified="2017-01-18" version="1">MLDLGPGGSRTFPTGDAELLVLPLAGSCTVTVDDETFEVEGRDSVFSRVGDFVYAPRDARVTVSTAAGGRFALPSARCENRLRPRYGPAEDVPVELRGAGQASRQVNNFCTPEAFPHADRLIACEVLTPAGNWSSYPPHKHDEDRPGECVLEEIYYFEIAAGPSGPGIGYQRVYGTGERPIDVLAEVRTGDTVLIPHGWHGPSMAAPGYDMYYLNVMAGPSAERAWLICDDPAHSWVRATWEGQPVDPRLPMTSAKGVEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XB67</accession>
    <name>A0A1H5XB67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08893">
        <property type="protein sequence ID" value="SEG08893"/>
        <property type="gene ID" value="SAMN04489712_103172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="41"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="180"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG08893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="38121" checksum="939ECBA95306B524" modified="2017-01-18" version="1">MALKSFRDRNRIAVGLVSSGTLIALVVGVYLVGTRGLLQDRYTVTGVFADTGGLRSGDEVQVAGIRAGEVTAVDPDFARGRVLVTWKIDGEVDLGPATRAEVRVANLLGGRYLRLSGPVTTPHLADLPDERRRIPLERTSTPTTAGDLLNSSTRTITRLDARSIDRIVSELGRLDARDRGRLGRALADLAELAQAVEESDPQIDKLLTNGERVMDLARTKERQLSQLLTNVQIMLDELKRRRDELSVFLGSGGRTVTAMTRLIDEQQHKLIAVIDDLNHTLGALRPTTKDFNELLAWAGPTLSGLAGAGGYGPWLEVVATGLGPLSPQDLAGLARLLPPDARGAGAGRGPGREGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XEL8</accession>
    <name>A0A1H5XEL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10208">
        <property type="protein sequence ID" value="SEG10208"/>
        <property type="gene ID" value="SAMN04489712_103221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG10208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="33871" checksum="5A1D59AC2F3BB287" modified="2017-01-18" version="1">MTDHAVLAQGVRKRYGGGTTALDGLDLAVAPGTVHGLLGPNGAGKTTCVRILATLLTLDGGRAEVAGFDVLREPARVRRRIGLVGQHAAVDEVLSGRQNLEMFGRLHHLPTRAARRRADELLERFGLRDAGRRPAGEYSGGMRRRLDLAAGMIMAPAVLFLDEPTTGLDPRGRSEVWETVRALAEDGTTVLLTTQYLEEADRLAGRISVVDRGRVIAEGTPDELKSGLGADRVDVVLRDPAALPAAADLLSGATGARVETDPDTRRLSAPVTDRVAALIEVVRALDGAGIDAEDIALRRPTLDEVFLHLTADRAEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XM85</accession>
    <name>A0A1H5XM85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12894">
        <property type="protein sequence ID" value="SEG12894"/>
        <property type="gene ID" value="SAMN04489712_103320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG12894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="70" mass="7811" checksum="45B98ABDA9FED186" modified="2017-01-18" version="1">MPGFLWSADAAPATALVNGEERYALHIGRKLARLNGVLWHSSDLTPQIRQGPPRVFGVAWRPDRVSISFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XW55</accession>
    <name>A0A1H5XW55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-lactate dehydrogenase (Cytochrome)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15620">
        <property type="protein sequence ID" value="SEG15620"/>
        <property type="gene ID" value="SAMN04489712_103425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03332">
        <property type="entry name" value="LMO_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037350">
        <property type="entry name" value="LMO_FMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="316"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG15620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="41029" checksum="AC6743CE10254774" modified="2017-01-18" version="1">MGSLADFQNEIYLEGLGGARPALPTDLTALEELAGRRLPAEAFGYVAGSAGSEATAVANRAAFDRRRIVPRMLRDVSQRDFSVEVLGTKMPAPLLVAPIGVLSILHPDGELAVARAAAGLGVPMVLSSAASFCMEEVAEASGAGSPRWYQLYWPKDRDLAVSFLERAKAAGYTALVVTLDTFTLGWRPRDLDAAYLPFLRGIGVANYFTDPVFQKAVGGPVTDANRDLAILHWVANFGNPSLTWDDLAFLREHWDGPIALKGIQHPDDARRAVDAGMDGVIVSNHGGRQVDGAVASLDALPGVAEAVGDQTTVLFDSGIRTGADIVKALALGARAVLVARPYAYGLGLAGEAGVRHVLRCLMAELELTTMLAGCTRPGDLTPDILTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YK42</accession>
    <name>A0A1H5YK42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron(III) transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24438">
        <property type="protein sequence ID" value="SEG24438"/>
        <property type="gene ID" value="SAMN04489712_10458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="53"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="308"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG24438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="503" mass="51950" checksum="A631954B2C7C5AC2" modified="2017-01-18" version="1">MTTARAPWVLLGPACLAGAFALLPLGYLAVRSLERGPGFAWSVVTTEGTALLLGRSLALAVVVVAACLLLGISLAWLTVRTALPGGRAWSVVATLPLAVPSYVAAFAWLSAVPELAGFTGSAVALTLVSYPYVYLPVAAALRGIDPAQEEASRSLGAGPVRTFLRVTLPQLRPAAAGGGLLVALYALSDFGAVSLMRYDTFTRGIYTSYRASFDRTPAAALSVVLVVMTVALVALETRTRGRRGHARTGTGTARPFTPVPLGRMTIPALAWCGAVVAAAVVFPLATLGYWLVAGNLATWDPAGLLNIAGVTLGVAAGGAALTTVLALPVGVVAARYRGRAADLLEQAAYAGHALPGITVALSMVFFAVRYANPLYQELPLLVCAYAVLFLPVAVGATRAAVLQSPPVLEDVARSLGRSPLRVLREVTVPLAAPGVAAGAALTFVVCMKELPATLLLRPTGMDTLATRLWTETGVGSYADAAPYAAALILLAAVPSYLLGRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YKY7</accession>
    <name>A0A1H5YKY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24664">
        <property type="protein sequence ID" value="SEG24664"/>
        <property type="gene ID" value="SAMN04489712_10467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG24664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="97" mass="10465" checksum="82D86C05B4C4F6A0" modified="2017-01-18" version="1">MGGVGPEVWIATADGRDMVRADAIVVVRLDGGRLTAQLRDESKQTVTLIDGATAAHPPADFHRRLVRTVAELADSSGAQLVRTACDENGWRWVTEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YUA6</accession>
    <name>A0A1H5YUA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR HTH family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27568">
        <property type="protein sequence ID" value="SEG27568"/>
        <property type="gene ID" value="SAMN04489712_104185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG27568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="311" mass="32864" checksum="8BBABFE549C18C29" modified="2017-01-18" version="1">MEPHWTITELAAAAAAALGDEPVRVNGRVRDLPNERLIRWYTTIGLVDPPSGRRGRTALYGERHLLQLVAVKRRQAAGRTIAQIQTELLGATDTILREIAGLPARPRPTPPSPPAGRPDAPPRDARDARAPRPAAPAQRVPAPDADRSDPLLQTSRTPRTDTPPQGSATPDVSWSEAPAPRPDTSAQGSPVPDVSWSNVLDEGPGPQEEHGASGARGRFWAQVPSTGESGAAPPAHQGGLPAVRPVPVSGVRLAPGVTLLLESAALTQADLEAIGRAAEPLLAELRRRGLFSDPRLIDDPASPTDLNGRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z2Z2</accession>
    <name>A0A1H5Z2Z2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-quinone oxidoreductase subunit F</fullName>
            <ecNumber evidence="12">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_104292</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30027">
        <property type="protein sequence ID" value="SEG30027"/>
        <property type="gene ID" value="SAMN04489712_104292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 12" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0874">Quinone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="13">
        <location>
            <begin position="328"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG30027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="433" mass="46868" checksum="2BDB19FFB84DFF45" modified="2017-01-18" version="1">MSTTLTPVLSRTWDQPDSFTLAAYEREGGYRAMRTAFGMEPDAIVQAVKDSGLRGRGGAGFPTGMKWGFLPPSSPNPRYLVVNADESEPGTCKDIPLMLANPHVLVEGVIISSYAIRSNHAFIYVRGEVLHVIRRLQQAVAEAYEAGYLGKDILGTGYDLELVVHTGAGAYICGEETALLDSLEGYRGQPRLKPPFPAVAGLYGGPTVINNVESIASVPSIVANGADWFASMGTEKSKGFGIFSLSGHVTRPGQYEAPLGITLRELLDMAGGVRKGHRLKFWTPGGSSTPLFTDEHLDVPLDFESVGAAGSMLGTRALQIFDETTCVVRAVQRWSEFYAHESCGKCTPCREGTYWYKQVFKRLEAGQGTEEDLQTLLDLSDNILGRSFCALGDGATSPVTSSIKLFRDEYIAHFTQGGCPFDPAKSTVWAGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z7N6</accession>
    <name>A0A1H5Z7N6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">SAMN04489712_104405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012854632.1">
        <property type="nucleotide sequence ID" value="NZ_FNVO01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32341">
        <property type="protein sequence ID" value="SEG32341"/>
        <property type="gene ID" value="SAMN04489712_104405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG32341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="11591" checksum="5FB84A9DB565689F" modified="2017-01-18" version="1">MAGQKIRIRLKAYDHEVIDSSAKKIVETVTRTGAKVAGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDIIDPTPKTVDSLMRLDLPAGVDIEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z8W4</accession>
    <name>A0A1H5Z8W4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="8" type="ORF">SAMN04489712_104434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32969">
        <property type="protein sequence ID" value="SEG32969"/>
        <property type="gene ID" value="SAMN04489712_104434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG32969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="14444" checksum="96B9D7569B7B0583" modified="2017-01-18" version="1">MARLVGVDLPRDKRLEVALTYIYGIGRTRALETLRETGISGDLRVHQLGDDELVRLRDWIDANYKIEGDLRREVQADIRRKIEIGCYQGIRHRRGLPVHGQRTQTNARTRKGKKKTVAGKKKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZYV7</accession>
    <name>A0A1H5ZYV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Superfamily II DNA and RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41649">
        <property type="protein sequence ID" value="SEG41649"/>
        <property type="gene ID" value="SAMN04489712_10591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="108"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="306"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG41649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="649" mass="70398" checksum="61448A02092C499E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2Q4</accession>
    <name>A0A1H6A2Q4_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Putative serine protease PepD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42026">
        <property type="protein sequence ID" value="SEG42026"/>
        <property type="gene ID" value="SAMN04489712_105113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
    </dbReference>
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        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="546"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="316"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG42026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="625" mass="63072" checksum="260DF59B6835EA0B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A6M1</accession>
    <name>A0A1H6A6M1_9ACTN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44383">
        <property type="protein sequence ID" value="SEG44383"/>
        <property type="gene ID" value="SAMN04489712_105249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="178" mass="19347" checksum="D874986DD8E7D007" modified="2017-01-18" version="1">MTQGTRSISPAALAVGRIITVCPDPMATEARQPGEWTMNRHPIEYGEFVRLDVTDPRGKASVWLVHTDHAVTVQLTRGEEQAAAARVIADLAGAGLPDIYEWEIRDGRVRAWLAAQSWEAAQSRADLAAWAEHLGCEVAEEEQDGRTLLTAAGEVDGVPVEVRTSIYDADKEKAEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A9H2</accession>
    <name>A0A1H6A9H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45012">
        <property type="protein sequence ID" value="SEG45012"/>
        <property type="gene ID" value="SAMN04489712_105282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG45012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="15567" checksum="36A15C0231A95BE3" modified="2017-01-18" version="1">MSGSDGVFTVAKGRVGHYAGLPAADDVLVGVLLQADGLEDDSVLADHDTLASVLSGGNAECDFTGYVRQVLAGVAWVVDDDAGTADGSVDVIVWPSAGGAHNNAVGKLLICYRPAAASTDEEIVPLTFHSVDVETNGSTVRVRLPSGFVRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABN8</accession>
    <name>A0A1H6ABN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_105348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46169">
        <property type="protein sequence ID" value="SEG46169"/>
        <property type="gene ID" value="SAMN04489712_105348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="283"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG46169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="42279" checksum="4BC315A16E6CB74D" modified="2017-01-18" version="1">MPEAVIVSTARSPIGRAFKGSLKDLRADLLTAQMVTAAMAKVPQLGADDIDDLLLGCGLPGGEQGYNMARVVSVLLGWDQVPGATITRYCSSSLQTTRMAMHAIRAGEADVIVSAGVEMVSRFAKGSSDGLPDTKNELFADSEARSAKAAEGGAGVWHDPREDGQIPDVYIAMGQTAENVASLRGVSRQAQDEFGVRSQNLAEKALANGFWEQDITPAILPDGSTVTKDDGPRPGTTLEKVSGLQPSFRPDGTVTAANCCPLNDGAAAVIVMSDTKAAELGITPLARIVSTGVSGLSPEIMGLGPVEASRRALARAGMTIDDIDLVEINEAFAAQVLPSAEDLGVDIDKLNVNGGAIAVGHPFGMTGARITSTLINSLRFHDKQFGLETMCVGGGQGMAMVLERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AGJ8</accession>
    <name>A0A1H6AGJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47197">
        <property type="protein sequence ID" value="SEG47197"/>
        <property type="gene ID" value="SAMN04489712_105407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG47197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="18526" checksum="96BFE1B0EC8BB430" modified="2017-01-18" version="1">MEDEVDRLVTAWQAERPDLDVRPLHVLSRVSRLARHLDRARRAVFAAHDLEPWEFDVLTALRRAGSPYQLSPGRLLRATLVTSGTMTNRIDRLEAAGLVRRHPDPADKRGVQVRLTDKGRTRVDAAFADLLNREHDILAGLSASERATLADLLRTLLAPFDAPPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AI19</accession>
    <name>A0A1H6AI19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron complex transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47727">
        <property type="protein sequence ID" value="SEG47727"/>
        <property type="gene ID" value="SAMN04489712_105437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292722" evidence="2">
        <location>
            <begin position="35"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="71"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG47727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="360" mass="37852" checksum="12E0AC0C66967AAD" modified="2017-01-18" version="1">MISQSRTRRCAPGVVALALASSLTACGGSPPTSAEGRTPSFGPAQRTSYPLTLDNCGQKLTFSQPPRRVLILNGASVGEVESLLALGLGKSVIANAQSYGVSDDPSMVAAIKALPTGGLSTNGNFDVPAEQVLAAKPDLVISTWSGGFDAKKGFATRERLAAAGIQTLVNPANCALGKPEATPEEKRALKNQSTNSSLEFIALLGRVFDVQQRAVELIGRIRARIDAVRTRVAGRPPKKVLIVYPGMAAMNANGLPAVMTGGIYDDIVTAAGGVNAFAGRGEETTRTLTKEQLATAQVDVLVVGRYTPAERPEAEATKLFAQFPHWNAAKTRTFTVVSDSVYLGPLNAVAVERLAQVMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZB2</accession>
    <name>A0A1H6AZB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53949">
        <property type="protein sequence ID" value="SEG53949"/>
        <property type="gene ID" value="SAMN04489712_106127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG53949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="949" mass="100457" checksum="5271C9BD05013E20" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B4H4</accession>
    <name>A0A1H6B4H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cobalt-precorrin 5A hydrolase / precorrin-3B C17-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_106256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55751">
        <property type="protein sequence ID" value="SEG55751"/>
        <property type="gene ID" value="SAMN04489712_106256"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="SSF159672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CbiG_N" evidence="9">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_C" evidence="8">
        <location>
            <begin position="218"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="346"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG55751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="585" mass="60251" checksum="F5D00F92E62FD7A6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B4M5</accession>
    <name>A0A1H6B4M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein N-acetyltransferase, RimJ/RimL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55809">
        <property type="protein sequence ID" value="SEG55809"/>
        <property type="gene ID" value="SAMN04489712_106261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="182" mass="20536" checksum="411B7E27229D08E3" modified="2017-01-18" version="1">MTFDRDITLTTDRLLLRPFTEHDVPDVLEAGRDREMRRWMAWAPNQTPAQAHEFCTRAAHEDPQQKICFAVEAAGRCCGSVSLQRAEWLFGRAEIGYWLAPWARGRGLITEAVRALVDYGFGKGLHRIELLAAVGNEASHRVAERAGFTREAVLREAGVLFGGERTDMVMFARLNRPRRSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B4N9</accession>
    <name>A0A1H6B4N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55514">
        <property type="protein sequence ID" value="SEG55514"/>
        <property type="gene ID" value="SAMN04489712_106237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="108"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="27948" checksum="42F5477C6483803D" modified="2017-01-18" version="1">MSTTAVQPHGVHERIVKLLASPPAEPDASAGYLDLLGPGGEPAPTPAQRVMQSTFLPQIYERLWRPIGFNLAKGWPAGPDTAEENALARSWLALGRPADPRKPDMTVLDVACGPGNVTRALAEGVGPGGLVVGLDASATMLARAVAEPVPGTVGYVRGNAGDLPFRDGVFDAVCCFGGLYLFKDPWAALDGMTRVLRPGGRLAILTSRRPAAPLVGRGSELAGRITGVAMFGDKEIVRALEERGYRQIRHRRLPLMQFAGGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6E9</accession>
    <name>A0A1H6B6E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C20-methyltransferase /cobalt-factor II C20-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_106260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55797">
        <property type="protein sequence ID" value="SEG55797"/>
        <property type="gene ID" value="SAMN04489712_106260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG55797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="239" mass="25067" checksum="6E2EB994F54111B2" modified="2017-01-18" version="1">MKLVGIGVGPGDPELVTVKAVRILREADLTLVPVMALDEQGRAESVVRAYTDRAERVVFALNDRGGVTSRRAAAWDGAADRVVSAFDEGASTVAFATIGDPNVYSTFTYLAQTVRSRRPGVTVETVPGVTAMQDLAARSGTVLTEGAESLGLVPLTSGVERLRDALRTCDTVVAYKFGAVADQVVEVLKEAGRLDDAVYGARLGLPGEKVGPARDLAGPVPYLSTLIAPSPRTSRGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BHC0</accession>
    <name>A0A1H6BHC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_107112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60141">
        <property type="protein sequence ID" value="SEG60141"/>
        <property type="gene ID" value="SAMN04489712_107112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
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        <property type="entry name" value="PEP_util_AS"/>
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        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
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        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="17"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="298"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="422"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="536"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="850"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="763"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="784"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="786"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG60141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="898" mass="97071" checksum="5EB1AE4841DB6E4D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BIM2</accession>
    <name>A0A1H6BIM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="12" type="ORF">SAMN04489712_107140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
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        <property type="protein sequence ID" value="SEG60570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60570">
        <property type="protein sequence ID" value="SEG60570"/>
        <property type="gene ID" value="SAMN04489712_107140"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:ribosomal small subunit biogenesis"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="16"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="215"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="50"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="71"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="71"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG60570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="310" mass="33783" checksum="A0BE28852B5FF7A1" modified="2017-01-18" version="1">MTSPQTTTEGTAGGFKSGFACFIGRPNVGKSTLMNALVGTKVAITSSRPQTTRRAIRGIVHRPDAQLIVVDTPGLHKPRTLLGERLDSLVRSTLTEVDVIGFCVPADEKVGPGDRFIARELANLSKTPVVAIVTKTDLADRQQVAEQLMRVQRLGDFADIVPVSAAGGFQVDLVGDLLISHLPPGMPLYPEGDLTDEPEHVLVAELIREAALEGVRDELPHSIAVVVDEMQPREDRDDLVEVYAHLFVERPSQKAIVIGAKGARLREVGTAARRQIEALLGVKVYLDLRISVAKDWQRDPKQLRRLGFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKH9</accession>
    <name>A0A1H6BKH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter ATP-binding protein, PAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_107188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61142">
        <property type="protein sequence ID" value="SEG61142"/>
        <property type="gene ID" value="SAMN04489712_107188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="40"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG61142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="30362" checksum="6AA0E1CC8EBC1CA1" modified="2017-01-18" version="1">MTDSGIEAGGTNLRKDDPPKDDVSGAPAGTPAPDDGSPLVRLEKVNKYFGQLHVLRDIDLSVQRGEVVVVIGPSGGGKSTLCRSINRLEPIDGGVIEVDGRRLPEEGKELARLRADVGMVFQSFNLFAHKTILQNVTLGPMKVRKVAKAEAEREAMALLERVGIGAQAAKYPAQLSGGQQQRAAIARALAMKPKVMLFDEPTSALDPEMVNEVLDVMTGLAREGMTMIVVTHEMGFARRAANKVVFMADGQIVEENTPEEFFTNARTDRARDFLSKILTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPP0</accession>
    <name>A0A1H6BPP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, CdaR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_107311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62650">
        <property type="protein sequence ID" value="SEG62650"/>
        <property type="gene ID" value="SAMN04489712_107311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="288"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="501"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG62650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="568" mass="61215" checksum="986BA9070B2D557D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BVG4</accession>
    <name>A0A1H6BVG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64427">
        <property type="protein sequence ID" value="SEG64427"/>
        <property type="gene ID" value="SAMN04489712_10823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="36"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="31832" checksum="1F96BA86AB391521" modified="2017-01-18" version="1">MTALFSSPDEVVRRLADVGYLADEAIATTVFLADALGKPLLVEGPAGVGKTELAKAVSAATGAGLVRLQCYEGLDEARALYEWNYKKQLLRIQAAPSDQGWEDTHDDIFTEEFLLERPLLAAIRRAEPTVLLIDETDKADVEVEGLLLEVLSDFQVTIPELGTVAAARRPLVVLTSNAARELSEALKRRCLYLHLDYPRPERERDIVLARVPGIEAELAEQLVRTVGALRALEIKKAPSIAETVDWARTLLALGLDELDEAAVARTLGVVLKHVSDQQRAVRELGLPADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BWP2</accession>
    <name>A0A1H6BWP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Transaldolase</fullName>
            <ecNumber evidence="6 7">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tal</name>
        <name evidence="8" type="ORF">SAMN04489712_10879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="6 7"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65124">
        <property type="protein sequence ID" value="SEG65124"/>
        <property type="gene ID" value="SAMN04489712_10879"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036915">
        <property type="entry name" value="Trnald_Bac_Plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG65124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="371" mass="41027" checksum="97C040800E664ECD" modified="2017-01-18" version="1">MSETLKKLSDEGVAIWLDDISRERLRTGNLEHLIRDRQVVGVTSNPTIFAKALGKGTAYDDQLRDLAVRGVDIEEAARAITTYDIRWACDVLHPVYERSDHLDGRVSIEVDPRLARDAEKTVAEARALWWMVDRPNLFIKIPATEEGLPAITRAIGEGISVNVTLIFSLERYGQVIDAYFAGLEQAREAGRDLSQIASVASFFVSRVDTEIDKRLDKLGSPEAEALKGKAGVANARLAYALYEEKFASDRWRALKDAGARPQRPLWASTGVKDPSLPDTLYVDELVAPGTVNTMPEATLEAAADHSEIRGDTVHGTYDEARALMDRLKETGVDYDDVVRVLEEEGVEKFEASWQELLSTIEGQLADKGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C236</accession>
    <name>A0A1H6C236_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Proteasome core protein PrcB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prcB</name>
        <name evidence="6" type="ORF">SAMN04489712_108217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66715">
        <property type="protein sequence ID" value="SEG66715"/>
        <property type="gene ID" value="SAMN04489712_108217"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_B">
        <property type="entry name" value="Proteasome_B_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5009356478" description="Removed in mature form; by autocatalysis" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023432081" description="Proteasome subunit beta" evidence="3">
        <location>
            <begin position="64"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3 4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG66715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="31008" checksum="768193E19FC1F47C" modified="2017-01-18" version="1">MVEGRSRVASHDSHTGRLPGMFMSPGTSSFTEFLGAHAPDLLPGRRMAQLAGGTPGSVEVPHATTIVAVTFPGGVVMAGDRRATSGNMIAQRDVEKVFRADEFSAVAIAGTAGIGMEIVRLFQVEIEHYEKTEGRTLSLQGKANRLAAMIRGNLGLAMQGLVAVPLFAGFDTERETGRIFSYDPAGGRYEEQDHYSIGSGSVFARGALKKLWRTDLSEADAALVCVHALYDAADDDSATGGPDLIRRIFPVVAAVTADGYRRLPEEEIADLAQSVVDERYDSPGGPTAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCT6</accession>
    <name>A0A1H6CCT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty-acyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70653">
        <property type="protein sequence ID" value="SEG70653"/>
        <property type="gene ID" value="SAMN04489712_109188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="438"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG70653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="526" mass="56555" checksum="0A556732C52D2890" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CFM9</accession>
    <name>A0A1H6CFM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71445">
        <property type="protein sequence ID" value="SEG71445"/>
        <property type="gene ID" value="SAMN04489712_109271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="549" mass="54591" checksum="07EA87559ECED002" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM64</accession>
    <name>A0A1H6CM64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent ferric siderophore reductase, contains FAD-binding and SIP domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74030">
        <property type="protein sequence ID" value="SEG74030"/>
        <property type="gene ID" value="SAMN04489712_110182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="27963" checksum="9F1E335CA03766E0" modified="2017-01-18" version="1">MSYRHFSAEVTRVDRLTPHMARITLGGLADFPGAGLDHRVKVFFPLPGEERPVYPTGDDWWERWQVEPVRAVFRTYTIRRHRPDLGEVDIDFVLHGDGGPGSRWALGARPGDQVGLWGPRAEYAPPPEADWVLLAGDETALPAIGALIEAFPPDTVARVFVEVASADERQPFDLPDNARLTWLCRDAGHSLLTAVREARFPAGRPYAWVAAESQTVKQIRRHLVNDRGIARDDIYFSGYWRRGRSQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQV4</accession>
    <name>A0A1H6CQV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75390">
        <property type="protein sequence ID" value="SEG75390"/>
        <property type="gene ID" value="SAMN04489712_11131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="25"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="32123" checksum="E96CB8EC327E18C3" modified="2017-01-18" version="1">MTELTERPAAQSGEFAIGGDLRVRRLGFGAMRITGSGVWGEPADRDEAIRVLRRAVELGVSLIDTADSYGPFVSEDLIAEALYPYPEDLVIATKGGFTRQGPNIWQPVGRPEYLRQCVEMSLRRLRLERIDLYQLHRIDPEVPLEDQLGVLRDMRDEGKIRHIGLSEVDVEEIEAARRIVEIASVQNLYNLSHRQAEPVLEYCERHDMGFIPWFPLATGKLAEPGGRLAEAAARHGVTPAQLALAWLLHRSPVMLPIPGTSRVAHLEENVAAATISLTPEEVEQLGDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CTU7</accession>
    <name>A0A1H6CTU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium/proton antiporter regulatory subunit, CPA2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76268">
        <property type="protein sequence ID" value="SEG76268"/>
        <property type="gene ID" value="SAMN04489712_111143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026278">
        <property type="entry name" value="K(+)/H(+)_antiporter_KhtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005028">
        <property type="entry name" value="KhtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="73"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="160" mass="16962" checksum="9645C81CDAEDC8C3" modified="2017-01-18" version="1">MDVERTALPGIGLQHVFTTRRGRQVGVVSHRTGRRDLAVYDKEDPDTCVVTVQLTPEEANVLAELLGTGRVVERLADLHRQVEGLVTELIPIMDGSPYDGRSLGETQARSRTGASIVAVVRGPQVHASPRPGFVFAAGDKVVVVGTGEGTAGVARILSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYI5</accession>
    <name>A0A1H6CYI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78112">
        <property type="protein sequence ID" value="SEG78112"/>
        <property type="gene ID" value="SAMN04489712_11230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="214" mass="22068" checksum="382EF04B4F8BC380" modified="2017-01-18" version="1">MTLTAGLLLVLTACLGGSDEPEIKGPVGDLAPTPSPSTATLKQHGGPAGGFTIGLPEGWQIVDPTTSSLDAVRTAFGIKGGELPELVEATLDELKKHNAVFAVETASLSTGYANHLTAVCAPGGAIGNDLDTLKRKSRALNGKHQGYRLTDVTVSGKPGLRASYTSTKSTGVTEDEVEIQVPGTGDKVCETQITTKQGAPAKDTEQILASFKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZ50</accession>
    <name>A0A1H6CZ50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78048">
        <property type="protein sequence ID" value="SEG78048"/>
        <property type="gene ID" value="SAMN04489712_11219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="6957" checksum="76D3C0C47E71FEFD" modified="2017-01-18" version="1">MSRFRFVADHAGVFDVRRLCWVLGVFRSGLYRWLRAAPVRAARRADDARLVACIGVVHAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZJ2</accession>
    <name>A0A1H6CZJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78450">
        <property type="protein sequence ID" value="SEG78450"/>
        <property type="gene ID" value="SAMN04489712_11279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG78450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="36129" checksum="52F896178AFC202C" modified="2017-01-18" version="1">MSAPAAARPSAARVVARGRRRSATRRRVIIATLAVLVVAGFAVTLMFGQTFYPPDDVVRVILGEQVPGASFTVGRLRLPRAVLAVVAGFSFGMAGVTFQTMLRNPLASPDIIGISWGASAAAAIAIVSLSLDRTQVSALAIVSALAVALLIYVLAFRDGVVGTRLILIGIGISAILESVTSYVLSRAAEWDLQEATRWLTGSLNGVTWDQTLPALAALVVLTPVLLHQARDLSAMQLGDDTASALGVRVERTRVTVIVAAVGLIAFATAAAGPIAFVAFLSGPIAARLVGVGGSLLVPAGLVGALLVLVADFAGQFAFDTRYPVGVVTGVLGAPYLVYLIVRTHRAGGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0S1</accession>
    <name>A0A1H6D0S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78206">
        <property type="protein sequence ID" value="SEG78206"/>
        <property type="gene ID" value="SAMN04489712_11246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="143"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="27587" checksum="71B11886F32BE701" modified="2017-01-18" version="1">MGEAFSPHRHDTYAVGVTLAGVQTFRYRGERHHCLPGQWHILHPDELHDGAAGTEDGFGYRIIYLDPALVQNALGGRALPFVADPVIRPTGMPPLPTGYLAHIDEPLDDLAAAEMTTAVADMLCAHAAASPLPRVAVDVEAMKRVRALLMDDPTTRHRAERLETVAGMDRWSVARQFRAAFGTSPTRFRTLRQLDMARGLLRTGHRPAEVATAAGFADQAHLTRMFKRAYGLTPAAWSAALGIDVGIGLRLGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2E2</accession>
    <name>A0A1H6D2E2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79447">
        <property type="protein sequence ID" value="SEG79447"/>
        <property type="gene ID" value="SAMN04489712_112217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295460" evidence="2">
        <location>
            <begin position="36"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG79447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="26614" checksum="6CDFB608426D8122" modified="2017-01-18" version="1">MVAVGYAAGTAGAALGLLRTSATMSQLINVGVAIAATAVANVPAMGDAAANWTAIAARMDGGVKGTESDIIRQVRQDWIADDGRAFIEVVNRFTAETEATRKFFDQVEKSLDDIGDAYRTYWYSILVMAGTALSVCLVAFAMLFTPLFPQGMAILQWMGALACKIIALLTTMLKGFLAIAATTLATGAKGMMQLFNIKPTGGAAIDFTQTRVDMNRFNDDFYQNPNRPNTAGGFHWVAPKRDEPEPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D342</accession>
    <name>A0A1H6D342_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79474">
        <property type="protein sequence ID" value="SEG79474"/>
        <property type="gene ID" value="SAMN04489712_112221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046175">
        <property type="entry name" value="DUF6177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19674">
        <property type="entry name" value="DUF6177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="33311" checksum="0CD9C59812FDE09C" modified="2017-01-18" version="1">MERGEPVSAVLDVLTAQAMVVLQDRPVVALTPWLAEALEECTGSGRTLQIVTPPSARLSMPLKAAGPAVQWIVHDGGGYYEGLTGRPMRWDGAVFGPVPDARDYAPGFLTRPSGPVGAQLTLTFRARHTRHGVLGGQVERLVTILTGRPPAGWGDSEPVAHGWQRSDLTSHVRERGAAATRLIVVGAGGGRSALATLEFSQGGTAEVTTLTVGHPPADPPAVAHLPALVETLVAEHPVSSLLAQLNPGRADVTYEPRWMGSPAPVGMAVAGDRSGPSGIPARPAGAGQAPMTWFELGDGRSPEGWQRHQALLRHLTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3Y3</accession>
    <name>A0A1H6D3Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79505">
        <property type="protein sequence ID" value="SEG79505"/>
        <property type="gene ID" value="SAMN04489712_112226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="376" mass="40716" checksum="763D3F7CC59D7483" modified="2017-01-18" version="1">MQLTSTAFISLLTVLAVVAIVATVWLMPRINGRGVRGHAARLGLLVACQLAIVLALSAGVNAYFLFYASWDDLLASGSGQVEVGKGKQGSAPVSRSELLSRSAPELSSQLGLKTPDRDGRLEQTTIRGLRTGLSSEAFVYLPPDYFKADNAKRNFPVVVVLTGYPGDPKVLVGRQELPKLALEELRAGRTQPMIYAFVQSTVVPPRDTECTDVPGGPQVETFFAQDVPDALRAAYRVAPTRDGWGLMGPSSGGYCAAKLAMRHSDKFTAAGSVSGYFKALKDATTGDLWAGSKALRNENDLIWRLENRPPPPVSILVASARKGEKKFPEAERFVALAKPPLQVDTAYLAEGGHNLKTFGRLWPETMRWMSSKLQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8X9</accession>
    <name>A0A1H6D8X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81293">
        <property type="protein sequence ID" value="SEG81293"/>
        <property type="gene ID" value="SAMN04489712_11419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="298" mass="32184" checksum="1F0878F83476B14E" modified="2017-01-18" version="1">MDLRLLGYVVAIAEEGSISGAARRLRLTQPNLSRQLRELERRLGVELFARGGRRLVPTAAGEALLRRAVRMLADAEAVPNDVRLAAEGKTGRLTVGFAGSGINGALGDALGRLRAELPDVDLSLVELFDDAEMSAGILDGNLDVAVQRLPVRDARLATRVWAREPLTLFLPSVHPLARTREPAPVSVLGEIPLVLWPRESAPHAHDEITALCHHAGIVPRIGARARTVQTILALVAAGFGAAVMADSYRVLHREGVTPRRLAGTATTLHLVWRAGDTDPLLTRFMAALNTVKARHRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9D8</accession>
    <name>A0A1H6D9D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81798">
        <property type="protein sequence ID" value="SEG81798"/>
        <property type="gene ID" value="SAMN04489712_114146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="410" mass="44507" checksum="A8756D80811E60A7" modified="2017-01-18" version="1">MVALRTVRLPGQVWGLAAPDQSGPLFVTSYRGRDPLGTVLTALDVSGQVLWQREFEGHPGPPRVSSDTGNVWIAHRTPGHDVVCEIDASGTVVQKIAPIRERSERLCAFAVLGQQVITAWLRVERGRLVLAGRAPRIALHDHDGGIRWSTPTALGKISYPGVVEVGVDTGWEVRPMRPWSPRSIRAHRRTPLMVAGDRVAATFSDDSSGIAVTFFLDAGDGRLIAATPPGPTEHKAILGPGEFLIGSQGYGAFSTSHYDVDGTVVRRWPTHTMPLVDSKGRIRGPEFENVTPSRSHFIALESDGTVRKGPHLSGYYTSYPVLDRDGTAVFWRDGRLLAVSAELQSRELLASPDDRRNVMSRTVLLERGQIAFALGDELLLVSDTGLSTMDDGPWPCANGGLHSNPVLQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAA7</accession>
    <name>A0A1H6DAA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81625">
        <property type="protein sequence ID" value="SEG81625"/>
        <property type="gene ID" value="SAMN04489712_114100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="6952" checksum="E67F1532EC3412F3" modified="2017-01-18" version="1">MALSMEEQRILAEIETHLVQDDPKLADRLSGLSRARWRRRMRLATAMVTALAVVAMVAMAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF20</accession>
    <name>A0A1H6DF20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3566 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_115160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83166">
        <property type="protein sequence ID" value="SEG83166"/>
        <property type="gene ID" value="SAMN04489712_115160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="3">
        <location>
            <begin position="145"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG83166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="26310" checksum="86B4C992B15E139A" modified="2017-01-18" version="1">MSTQPNKSTNRPSETDPATGPGANGTGPAKGDAQPSGPASPSGPAKGGASFPDATRPEGIAPVRDSEPAWSAGPSAGPSGASKPMGAPDMAPPSPQGGAPVPVGRPGAGGPAGAGGPGGPGGAGGAAGKAKRAVARLGGSGGKSPRRAQLQLSRLEPWSVMKFSFVMSLVAFIVLLVAVVVLYVILSGLGVFDAISETVNDLTRDQNESTTGVDAGGWFGFGRIFGYTVLVGALNVLLITALSTVGSVIYNLAADLVGGVEVTLKEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF50</accession>
    <name>A0A1H6DF50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_115168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83196">
        <property type="protein sequence ID" value="SEG83196"/>
        <property type="gene ID" value="SAMN04489712_115168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="11211" checksum="06404EF8C1E0389A" modified="2017-01-18" version="1">MGFDRARFEAANVRVAFGPRRLHLAALDAVLAGRQELACGIVARSGVPMLTVVAVGAAHRPVEVGCDYLNGAWLFTWADSGKPIGPVTDLARVADQVAAALTGNGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGE7</accession>
    <name>A0A1H6DGE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84557">
        <property type="protein sequence ID" value="SEG84557"/>
        <property type="gene ID" value="SAMN04489712_11724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="18938" checksum="2D96237330730ABA" modified="2017-01-18" version="1">MDLTPYVDHLRRELAVAAEAGGEDARALAERLTGPLESAVRLALLEALSAAADEITSDLAPGSVEVRLRGRDPDFVVTPPPAEPAEEASGGGPGAAKGGPGAPPPAPLPEADEGGGTARVTLRLPEQLKPRIDEAAARMGLSVNAWLVRAVSAALEPDDRDRRPAQGEGRQFGRRYTGWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHR1</accession>
    <name>A0A1H6DHR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lysine 5,6-aminomutase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_117102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84967">
        <property type="protein sequence ID" value="SEG84967"/>
        <property type="gene ID" value="SAMN04489712_117102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028991">
        <property type="entry name" value="KamE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036843">
        <property type="entry name" value="KamE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16554">
        <property type="entry name" value="OAM_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117778">
        <property type="entry name" value="SSF117778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="110"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="27327" checksum="860507D00E25D818" modified="2017-01-18" version="1">MTADSASTQIIRPYGDTTGDGMVQVSFTLPVPHGLRAQAAALHLAAAMGLEPASVVHAKPMGPDFTFFIVYGRVRHLIDYARIPEPPGRAYPLLTAAEINLAVRAALGRRLVVVGACIGTDAHTVGIDAILNVKGFAGEKGLEYYREIQVVNMGAQVAVEELLARARAEGADAVLVSQVVTQRNAHLDNTRRMAAAFAAAYPDAAGPGRGRPLLVAGGPRFDTVTAADLGVDKIFGRGTTPAEVASYLVHALLPAAGAGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIJ6</accession>
    <name>A0A1H6DIJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_117118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85034">
        <property type="protein sequence ID" value="SEG85034"/>
        <property type="gene ID" value="SAMN04489712_117118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAP_DH_C" evidence="1">
        <location>
            <begin position="148"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="36718" checksum="2B7855E7AC47E67F" modified="2017-01-18" version="1">MTPAPARGHRVVQWATGNIGTRALRGVIEHPNLTLAGVYVHSPDKAGVDAGVLCGLAATGVTATRDADEIVALGADCVLYMPAACDFDEVCRLLESGANVVTTRGEFHRPDSLDPGLRKRVEAACERGGTSIHSTGSSPGFITEAVPLVLTSIQRRLDRLTISEFADLSQRDSPGLLFDVMGFGKPPAELDERRLAHGRISFGPSLELVAEALSMPLDSLEASGEVATARNTTRIAAGALEAGTVAAQRITVSGVRGGRAVLRFRATWYCTTDLDASWDIRDTGWHVAVEGDAPLDVDLRFPVPLERMAATSPGYTANRAVNAVPFVCAAAPGIRTSVDLPQIIATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKM3</accession>
    <name>A0A1H6DKM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_118119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85967">
        <property type="protein sequence ID" value="SEG85967"/>
        <property type="gene ID" value="SAMN04489712_118119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="42" mass="4409" checksum="E19062AFB197A751" modified="2017-01-18" version="1">MFVATAATLRRMGMVNAIVLVAVLGVVAVLSVLLVIALSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLB3</accession>
    <name>A0A1H6DLB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_118110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85931">
        <property type="protein sequence ID" value="SEG85931"/>
        <property type="gene ID" value="SAMN04489712_118110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="83" mass="9199" checksum="0C20B85D7F254A7E" modified="2017-01-18" version="1">MVIMTVRLGDNYWLWLAPILLGLALVTWLLLTLRAARRRVPHPEKLPGGSPHRGPIQGGTFEGDPGQRNPGEGSYDDRSAERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLQ4</accession>
    <name>A0A1H6DLQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system, OmpR family, response regulator RegX3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85783">
        <property type="protein sequence ID" value="SEG85783"/>
        <property type="gene ID" value="SAMN04489712_11879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG85783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="25201" checksum="99C3DD0976EE1347" modified="2017-01-18" version="1">MTRVLVVEDEESFSDALSYNLRKEGFEVAVAATGPDALEIFERNGADLVLLDLMLPGLPGTEVCRELRARSNVPVIMLTAKDSEVDKVVGLELGADDYVTKPFSTRELIARMRAVLRRQGDVEEPTPATLEAGPVRMDVERHVVSVDGESVQLPLKEFELLEVLLRNAGRVLTRMQLIDRVWGADYVGDTKTLDVHIKRLRAKIEPSPSTPRYIVTVRGLGYKFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DME8</accession>
    <name>A0A1H6DME8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85755">
        <property type="protein sequence ID" value="SEG85755"/>
        <property type="gene ID" value="SAMN04489712_11873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="124" mass="13315" checksum="112739A1B773612B" modified="2017-01-18" version="1">MRIGNVYRPGVLGCQADDRLSDAARRMTEEKVGALAVLDGDQITGIITERDLVSAVAAADDPGSAAVAAYTTTRVQTAGMDEDSQQVARRMLDAGIRHLPVEDHGRMVGMVSMRDLLALETWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMQ2</accession>
    <name>A0A1H6DMQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85875">
        <property type="protein sequence ID" value="SEG85875"/>
        <property type="gene ID" value="SAMN04489712_11897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG85875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="903" mass="96652" checksum="5414E54D1CF073A6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMW4</accession>
    <name>A0A1H6DMW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_119128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86622">
        <property type="protein sequence ID" value="SEG86622"/>
        <property type="gene ID" value="SAMN04489712_119128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="23069" checksum="C379A9ABBA00711A" modified="2017-01-18" version="1">MQSGETPLTERGARTREKLVVAAREVFEERGFLDTRVAHIARHAKVAYGSFYRYFPTKEAIFLEVADRLFADMTDHGVLPSPGPSPAARIRRANRAYYEAYLRNARMMAIIEQVATFNEDFKELRRKHRAVSVARSARAIERWQSEGLVDASLDPEMTARALAAMVDHSLYLWLVQEEDHAGTERLLDTLDALNIRALGLAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNQ1</accession>
    <name>A0A1H6DNQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86403">
        <property type="protein sequence ID" value="SEG86403"/>
        <property type="gene ID" value="SAMN04489712_11974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="48"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="27378" checksum="7909D88833935417" modified="2017-01-18" version="1">MTTTEADRADQGLGYAVNAPYYDLIFPEQVRDFLAAALRLLPEDARAVAEIGPGTGQFTEILAGMLGPEAEIFAIEPARVMRAALVTRLARLPEAARKVTVLLEDALTAQMDVPLDGVVLFNLIMHFSPADRPALWKKWAEALRPGGVLLVESQFPQTAVAVPPSVVPGRSLGRHRYETLSRAETVGEDLIRWVMTYRTLRGDVVMREETAEFDCHVVSDETLAAELTAAGLEPHPDAPEGVQVWRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPD7</accession>
    <name>A0A1H6DPD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86506">
        <property type="protein sequence ID" value="SEG86506"/>
        <property type="gene ID" value="SAMN04489712_11998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="124" mass="13678" checksum="7859898EFE2D2F44" modified="2017-01-18" version="1">MDVAAVSQAVALMAATGAVSGMGQHTALEVVERIRERVREVFGRDERSTESLEHAIEEPGDEARVRALAEALAWYAQRNEGFAEELDQWARDYEPSATVSQNVRAGRDAYTAGRDMTINQRPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQG7</accession>
    <name>A0A1H6DQG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_120136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87460">
        <property type="protein sequence ID" value="SEG87460"/>
        <property type="gene ID" value="SAMN04489712_120136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="302" mass="34105" checksum="EEC2F434F825F076" modified="2017-01-18" version="1">MPRRAHTARHRRLVQELRRLREQAGLRQEDVARELDWSLSKQEKIERGAISVRIADVRAMLDLFGLSGPKHREQYDALVRLARDARVKGWWNDYADAIPGWFESYVGFEADASGLLIFQDQVIPGLLQTEDYARAIYEAVRPALAANQIDRAVAARMERQSRLTGDQALKIHAVLDEAVLHRRFGGSAVLHEQLLHLERMARHPQADIEIQVRPFTAGAHPSVGTSFVILRFQGPEDTNPDVVYLEDLTSSAYLEEDPHLFRYNLAFKGLSATALPEDESIDLIGRVAARLLEQEGGRDGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQW3</accession>
    <name>A0A1H6DQW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsf</name>
        <name evidence="10" type="ORF">SAMN04489712_12046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86985">
        <property type="protein sequence ID" value="SEG86985"/>
        <property type="gene ID" value="SAMN04489712_12046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="9">
        <location>
            <begin position="72"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG86985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="30260" checksum="1EDCBA1A847B4D4C" modified="2017-01-18" version="1">MANFTAADVKRLRELTGSGMMDCKNALVESEGDFDKAVEILRLKGAKDVGKRAERTAGNGLVAEHFNGTGDGAILELNCETDFVAKNAGFIELADRIVRFAAESDAADAPALLGLEIEPGKTVQALIEENSAKIGEKLELRRFAHFKGAYVTSYLHKSDPSLPPTTGVLVQLDTENPEIGKDIAQQIAAMAPKYLTRDDVPAEAIEKERALAEQITRDEGKPEKAIPKIVEGRVNAYFRDFVLVEQAFVKDGKKTIAKVLDEAGVKVERFARFKVGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DS50</accession>
    <name>A0A1H6DS50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bilirubin oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88058">
        <property type="protein sequence ID" value="SEG88058"/>
        <property type="gene ID" value="SAMN04489712_12166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="549"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="646" mass="71672" checksum="3D7443AE55498F5C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUD6</accession>
    <name>A0A1H6DUD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_122103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88901">
        <property type="protein sequence ID" value="SEG88901"/>
        <property type="gene ID" value="SAMN04489712_122103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="39" mass="4280" checksum="E259B176FB82F1BB" modified="2017-01-18" version="1">MTENAPDTTLTLSAVAKLLAIEEIKGVFAERLRCMDAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVK4</accession>
    <name>A0A1H6DVK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol alpha-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89229">
        <property type="protein sequence ID" value="SEG89229"/>
        <property type="gene ID" value="SAMN04489712_12346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG89229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="40856" checksum="6262EC3770BE0A50" modified="2017-01-18" version="1">MKIGIVCPYTWDVPGGVQQHIRDLAEALIAVGHQVSVLTPADDDAPLPYYVVGAGRAVPVPYNGSVARLAFGFLSAGRVRRWIREGGFDVLHVHEPAAPSLGILACWAADGPIVGTFHASYERSRMVSVTAPILQSALEKVTGRIAVSEAARKTLVEHLGGDAVLIPNGVATERYAMADPLPGWPGRGDGAEPRPDGGTLGFLGRIDEPRKGLQVLLKAFEILGRRRPGLRLLVAGPGDADDVLAKVSPQLRDRVVMLGLVSDEDKIRAYHSVDVFVAPNLGGESFGIVLAEAMSAGAPILASDIEAFRRVLLDGRAGALFPVGDHEALAEAAAELLDDPARRKLLSAEARAAVRAYDWSTVARDVVRVYETVAVDGAGVVESGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWF1</accession>
    <name>A0A1H6DWF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89672">
        <property type="protein sequence ID" value="SEG89672"/>
        <property type="gene ID" value="SAMN04489712_12422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG89672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="21146" checksum="FAAF28592CB1DE75" modified="2017-01-18" version="1">MSHSEKPALAQPRPVRSLSERFDEVFDAHFDEIHRYVAARLGPDAAEDVVAETFLTAFRKRHAYDADRAAVRTWLFGIATKLVGKHRRAEVRALRALGRRGPDRPAAGPEERVLEEVSARRLRPELAAAIAGLNRGERDVLLLMALAGLGHDEIAAVLGVSYGTVGSRLSRARKKLRAALGGVNPMLEEDGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYR8</accession>
    <name>A0A1H6DYR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90478">
        <property type="protein sequence ID" value="SEG90478"/>
        <property type="gene ID" value="SAMN04489712_12650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="389" mass="40336" checksum="32FDCC12F508BB4E" modified="2017-01-18" version="1">MRSLNGAAVIVGAYEHPGRRLPGRTLAQVHREVVTGALADAGLGPEDVDGFFCDSSAPGYGAIDLMQYLGLRCTYTESGEMGGASYIAYVGHAAAAIAAGKCRVAVISLAGLPSHRRPPAPPETPSPAVAFQVNGYQGGYGPVADYALLARRHMHDFGTTPEQLAWVKVASSRHAAHNPNAFLTDVVTVDDVLGSPLIADPLHRLDCCVVTDGGGALVVVHPDVAASLGRTGAVLRGHGESHKTSFAGEVDLTYSANRRSGELAYAEAGVGPADIDYASLYDSFTITVLLALEDLGFCERGEGGRFVEDGGLVSGSGRLAVNTDGGGLSNNHPGNRGGMTKVIEAVRQLRGEAHPAVQVPGCRLALASGTGFRLGANHYSSTIILERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZK3</accession>
    <name>A0A1H6DZK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RHS repeat-associated core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90186">
        <property type="protein sequence ID" value="SEG90186"/>
        <property type="gene ID" value="SAMN04489712_12563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040559">
        <property type="entry name" value="CdiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003284">
        <property type="entry name" value="Sal_SpvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18451">
        <property type="entry name" value="CdiA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03534">
        <property type="entry name" value="SpvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296400" evidence="4">
        <location>
            <begin position="40"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="domain" description="HintN" evidence="5">
        <location>
            <begin position="1999"/>
            <end position="2105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG90186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="2275" mass="247264" checksum="47D33A3F1DCCB944" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZX2</accession>
    <name>A0A1H6DZX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_12753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90837">
        <property type="protein sequence ID" value="SEG90837"/>
        <property type="gene ID" value="SAMN04489712_12753"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="328"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="261"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG90837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="445" mass="47996" checksum="EB6484307FAA3AD3" modified="2017-01-18" version="1">MAHHRLTVIGTGYLGATHAACMADLGFEVLGLDVDKDRIDRLSAGDLPFYEPGLEQVLRRNLAAGRLRFTTSYDEVAEFGDVHFICVGTPQKPDEYAADLSYVDEAVGALAPRLERRCLVVGKSTVPVGTARRLAGRLARLAPANGDAVLAWNPEFLREGFAVEDTLHPDRIVIGVPDDPDAAAWAEQVLREVYASMTAEGSPFIVADYPTAELVKVSANAFLATKISFINAMAEVCEAAHADVTKLSEALSHDDRIGGRFLGPGLGFGGGCLPKDIRAFMARAGELGVDQALSFLREVDAINMRRRIRMVDLARELLGGSFIGRTVGVLGAAFKPNSDDVRDSPALDVAATIRSQGAKVTVYDPQALDNARRAQPSLAYGGSTLDAARDAHVVLLLTEWAEFREMDPDALGAVVAEKNIVDGRNALDKERWRAAGWNYRALGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E065</accession>
    <name>A0A1H6E065_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylated-DNA-[protein]-cysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90759">
        <property type="protein sequence ID" value="SEG90759"/>
        <property type="gene ID" value="SAMN04489712_12730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG90759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="170" mass="18045" checksum="9BEE46C750CD85B2" modified="2017-01-18" version="1">MIKAMVLETPIGPLALLEHDGALIGGGFTADPGELHVRLHPSLRALELTATGDLGDLSKAHLAYFDGDLTALDTVPVHQPGSPRRERLLAALRAVRPGETVTYGELAARAGLERAARAAGQACAQNLVAPVVPCHRVLPAAGGKGLKRFGGYYYGPERKEWLLSHEATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0M0</accession>
    <name>A0A1H6E0M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG90971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90971">
        <property type="protein sequence ID" value="SEG90971"/>
        <property type="gene ID" value="SAMN04489712_1283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15222" checksum="CFBEA5005F78AE58" modified="2017-01-18" version="1">MGERIEFRPDGPHSDDYTTDLARAFAEAVRVLNHATMRAGLHYPSTVYDMTGNLATGTAGLGQLVSQIGAFLKREATAGNLADTSGTDPRLTVRDAALAIQDAECAAAALADALRDIQSAVSGLYVPDPDEPEKTSGETGKDGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E235</accession>
    <name>A0A1H6E235_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG90975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90975">
        <property type="protein sequence ID" value="SEG90975"/>
        <property type="gene ID" value="SAMN04489712_1284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="132" mass="14638" checksum="32A0420FB2502380" modified="2017-01-18" version="1">MVMRRRTMAMFFDPAGTRYGVPTWPWRMAPPHLLTRRQLAACGLRPGGQPIAGQVLWRSRRYNAPGGVRAAYLYDVRLALPKRIASPAQRAALAKALTVRRTCPECGTDAGYVLSRHLGVCLECADAWEIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3N4</accession>
    <name>A0A1H6E3N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91505">
        <property type="protein sequence ID" value="SEG91505"/>
        <property type="gene ID" value="SAMN04489712_12940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296508" evidence="3">
        <location>
            <begin position="34"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="50"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="43554" checksum="EB1C8E1255739EBE" modified="2017-01-18" version="1">MNRFRVRAGTAGLVLLALAATSCGSGKATGGSAQTGSDGVKQGPGVTDDTISVGMISDLTGPYAPLGKSITQGSQLYFEQVNAAGGICGRKVEPLVRDMGYDVQKSVTAYTELAPKSAAFAHFIGSVTVGAVRQRLDTDGPLTLALAWAPSLLGSKSIQMTGTTYAIDVINGVDYLAKEKGLKSGDKIGHVYVEGDYGIDSLAGSKYAAEKLGFQVVEQKVKATDADMSGQVAVMKDAGVKAVVLSISPKQTASMVGVAVSKGLNVPFLGSNSSFAPQLLATPAAPALLKGFHVMQSASPLNSDLPAMKKLVADYRAKYPKDTLDNGVMAGYTTAAITGDALKKACANKDLTRQGIISAHRSTSAWDGGFGTTMDFTKIDEPPTRTTHILQPDKTAVGGLKIVREATASDLANGYKIALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E522</accession>
    <name>A0A1H6E522_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92790">
        <property type="protein sequence ID" value="SEG92790"/>
        <property type="gene ID" value="SAMN04489712_13531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="239" mass="26292" checksum="9A2184A567EB7BD8" modified="2017-01-18" version="1">MQDQLSGLDSTSLAERAYRRLRDLIVEGALAPGERVTERGLAERLSVSPTPVREAIKRLEADGLLERKSPRTVCVAASVSGTPQQLAEVEVALRGLVARLAAVHATDADIAHLTRLLDAAEDQTRLYAARVAEGLPIDGHAENLYASVQQFNAAVLASTHNPVLIRLFEQTRALSSVERRKRSVDRLRKDPTFGRSRWESHRSTLDAIRAHDPERAERIAIERAQSAMRDLAGNLPGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5C7</accession>
    <name>A0A1H6E5C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase conserved C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92409">
        <property type="protein sequence ID" value="SEG92409"/>
        <property type="gene ID" value="SAMN04489712_13346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="4">
        <location>
            <begin position="504"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="801" mass="85662" checksum="9C771FFE0EC71083" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E667</accession>
    <name>A0A1H6E667_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93137">
        <property type="protein sequence ID" value="SEG93137"/>
        <property type="gene ID" value="SAMN04489712_13723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="23099" checksum="8A47E1BD27F9B4FA" modified="2017-01-18" version="1">MSPEDPACRCALDSLASCLERAGGVVVRKIMLNSGGGRKSTALRVLNAANAQVNATVSCHLDEGVPGRVLFAWAGGDVISAVSPEEAAASVLAALGLSASPPNRREVEHVAVVRATEPDKGQTGRWRADPALTQMRVRLLADLAIALVERGQASRMVVEANGEAVLMLRSAWGRNSVGVVVIRRGQNWAYLWDGSRRRPISDMDDVRAAAAELAGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E874</accession>
    <name>A0A1H6E874_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein, Cse1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93897">
        <property type="protein sequence ID" value="SEG93897"/>
        <property type="gene ID" value="SAMN04489712_14125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013381">
        <property type="entry name" value="CRISPR-assoc_prot_Cse1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09481">
        <property type="entry name" value="CRISPR_Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02547">
        <property type="entry name" value="casA_cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="560" mass="61492" checksum="FC950A3C7DF6135C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8F0</accession>
    <name>A0A1H6E8F0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93541">
        <property type="protein sequence ID" value="SEG93541"/>
        <property type="gene ID" value="SAMN04489712_13926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="90"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="32976" checksum="8320C3678CDA5DCD" modified="2017-01-18" version="1">MTFPEGAPVIDTMIAFPQEGSAQYDFIRKQTKDVSSKEEMEFPAEYMFKQVPKDLPTDDPISVTLREMDRYNIRWGLIGVEDEVSRLALKKHPDRFVASGNIDPNTGMDGIRTMVREYEEFGIRAVGAFPAGTFPQVAINDKKMYPFYAKCVELDIPIFVCAGVPGPRLRMDPQRVELIDEVMFDFPELTLVTRHGCEPWTDLAVKLMLKWPGLHYSTSAFAPKYYPKAIIDYANTRGADKVLYGGYFPMGLSLERIFTDMPRVPFRDEVWPKFLYENARRLLKLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8Y3</accession>
    <name>A0A1H6E8Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Resolvase, N terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94268">
        <property type="protein sequence ID" value="SEG94268"/>
        <property type="gene ID" value="SAMN04489712_1453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="86" mass="9496" checksum="6AE1205D5D16B737" modified="2017-01-18" version="1">MRLFEDPATTSKIPVLERPAFARVAAAAHPGDTLTVSELFRLCRDLVDIHNVRAWCQARGLALRVLSGPLSNFHDLAASDTRPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9B3</accession>
    <name>A0A1H6E9B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93863">
        <property type="protein sequence ID" value="SEG93863"/>
        <property type="gene ID" value="SAMN04489712_14112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="48"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="344" mass="38285" checksum="AA536A0B28AC68D4" modified="2017-01-18" version="1">MAVTESLAATLRRRSNNHSPVTTGFEALTGYRWHEPTPARLAAGHRLSVVIPAHNVAHCLRYVLDALAVQSVRDAFEVIVVDDASTDETLSIARAHPIVLRLVRIRERAGAATARNVGTALAGADTILYLDADMVLPRHVIADVMVRAAANLALIGFRHNLPYKARQRVQESGMMPDLYADHRARWRPPVGRRLMYSGLVLDRPLDGRPLDHTKDLRDLGFGRGYYDWDLPRMVVTALLAVPREAVLDVGGFDPEFGRLGWGMEDTHLGAKLIASGLLVVPLRQAVGFHLDPPDAEAQWRAKLIGWRHTLAYYRGLLQRPAPTGRTHEFTTHLNTLRAQCEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9V1</accession>
    <name>A0A1H6E9V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegT/DnrJ/EryC1/StrS aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93879">
        <property type="protein sequence ID" value="SEG93879"/>
        <property type="gene ID" value="SAMN04489712_14118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="380" mass="40716" checksum="29F529647B877B97" modified="2017-01-18" version="1">MHYSPVPESPVYGYGCLTAEPQLERVSRAIASGRLSAIGGSQVPELERLTAFYTGRAYALATSSATAGLEVALRALGIGGGWEVVVPALGWVSVAGAVAATGATVRVAPIEESLTPSWDHIAPLVGPTTAAVVVAHLRGRPASDIARIAAELRNREIPLIEDCAQAWGAGNDHSRPVGRYGKVAVFSVQAYKLIAAGEGGLTVCDDADLMAKMRTLAGDTRVPAYRPTWRGNSRMSEITAALAIPQLQALDDLTGQLRRLQRQVADLLTEQSSAEIVLPQDREPDDSNGMHVGAWWPSAQAAQTLWQECYSTGLCAWHPTPGDLHSHHAWPVQAESESADISRYLDLQIPALHPRLHHTFLDSVRSTLDKAGLLTRPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EA04</accession>
    <name>A0A1H6EA04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93756">
        <property type="protein sequence ID" value="SEG93756"/>
        <property type="gene ID" value="SAMN04489712_14030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IclR-ED" evidence="1">
        <location>
            <begin position="167"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="43010" checksum="36ACC77A700C0D4A" modified="2017-01-18" version="1">MTGPAESFDARRFREVLGHYPTGVVVITAISESGAPVGMVVGSFTSVSLDPPLVAFLPSRTSNSFAQLRTASSFCVNVLAADQEQVCRQFAAKTGDKFAGVAWRAAPSGAPVLEEAVAWIDCDFDDVHEAGDHFIVLGRVRDLGILNPTPPLLFFQGGYGAFSPGALVAPYEGDLLNHIRLADAAREHMERISAELELECYAQGIVADELVIVAGSGTQRSTVRGHIGRRMPFAPPYGALFVAGRGQEAVDAWLSRRNLPLTDEDRDHYRGMLQRVADRRWSIALRAPEHDEVWDEIDQFSTAPRTPGLERRMGALLERLKGHYEPQELAGDELHDVRLLGAPVYGPDGSVVQVLALFGMPPQAGVEQIAAWRDRLAQAADAVTAAIGGRAPDARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S0L1</accession>
    <name>A0A1H5S0L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative copper resistance protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_1013</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43301">
        <property type="protein sequence ID" value="SEF43301"/>
        <property type="gene ID" value="SAMN04489712_1013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009283517" evidence="9">
        <location>
            <begin position="31"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="10">
        <location>
            <begin position="231"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="659"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="659"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF43301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="735" mass="77139" checksum="E7093085B5C2E4F9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SML7</accession>
    <name>A0A1H5SML7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51081">
        <property type="protein sequence ID" value="SEF51081"/>
        <property type="gene ID" value="SAMN04489712_101252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="478"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF51081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="818" mass="87325" checksum="9EF9C4417D51B62C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SN68</accession>
    <name>A0A1H5SN68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">mRNA interferase MazF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52062">
        <property type="protein sequence ID" value="SEF52062"/>
        <property type="gene ID" value="SAMN04489712_101290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF52062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="101" mass="11378" checksum="C5A9379618594143" modified="2017-01-18" version="1">MKRGQVWRLQTVNRERTGIVVLDDVFVPHLRGIQVVPIKDPGEVPETVLSVRIDTPVTGIAAVYDVGPFSPKRFIEHIGDVEQPVLDHMEIALRLLFGIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SNM6</accession>
    <name>A0A1H5SNM6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murC</name>
        <name evidence="15" type="ORF">SAMN04489712_101265</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51431">
        <property type="protein sequence ID" value="SEF51431"/>
        <property type="gene ID" value="SAMN04489712_101265"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="121"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="321"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEF51431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="471" mass="49002" checksum="8E8CBD773F25ACDD" modified="2017-01-18" version="1">MSRAAGPGGENGGEAIKHAHFIAIGGAGMSGIARIMLRRGIAVSGSDARDSEMLAHLASLGAEVFVGHAAEHLGDADTVVVSTAIREDNPELQAARERGLRVLHRSEALAALMTGRRAVAVAGTHGKTTTTSMLTVVLQHAGADPAYCIGGQLVTTGLGADDGTGDVFVAEADESDGSFLRYRPHIAVVTNVEADHLDNYGAFEQVKENFARFVERVGPGGALVASADDPVARELADGARGRGLTVLTYGEAADADLRVTGFSPRGLGSRFEIEGLGELTLGVPGRHYAHNATAAVAVAQLLGHDFATVREGLASFTGSMRRLERKGEAGGVQVFDSYAHHPTELTADLRATRDYVGQLAAEGRAGRIVAVFQPHLYSRTRFFAAEFGQALGLADVAVVLDVYGAREDPEPGVSGRLIADAVPDGTRVEYVPVWDEVPAVVAGLARPGDLVITLGAGDVTALGPLILARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SNS5</accession>
    <name>A0A1H5SNS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52104">
        <property type="protein sequence ID" value="SEF52104"/>
        <property type="gene ID" value="SAMN04489712_101292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF52104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="30624" checksum="33DEB5C492931EF1" modified="2017-01-18" version="1">MDDEIRALLARHLPGRPVRSVVRLGEGYDNVAYEVDGELVVRFSKEDDPEERSAAIRRDADLLTAVAALSPLPVPEPVFADPEAGVLGYVKVPGAPLHENPVAEPARLAPALGGFLGALHQVPLERMDGLVEPDTAPFTEWLAEAEDDYRAGAGRIPAAARAAIEDFLGSAPPPEPRDLVFCHNDLGAEHILVDVRAGAVTGIIDWTDAAVTDPVHDLGLLYRDLGPEVFELVVARYDGGLDEAGRERALFYARCGVLGDIAYGVRTGRRPYLDNALANLGHTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SS48</accession>
    <name>A0A1H5SS48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53240">
        <property type="protein sequence ID" value="SEF53240"/>
        <property type="gene ID" value="SAMN04489712_101336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="86"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF53240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="27118" checksum="6A4496CFC62E7E57" modified="2017-01-18" version="1">MGRNRRDSARKRMAELRAREAARAHRRRALATVLGALVVIAVTILAVVLLRGGENSRSGYRGSLAPLTRQADGSVVMARPGVSGPVLEIYEDFQCPACKSMEEATGKTVKELAAAGEAKVVYRPFWLFRNSPEPTRGNSLRALNASLCAPADTWIAYHDRLFAEQGPENSPGFRDEDLISWARQVGIGDGGFASCVTGVRKSAQIDQADAAATKAGVQSTPWVTLNGRRLDQKTVFTPDGLRRAVREVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SUH4</accession>
    <name>A0A1H5SUH4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ORF">SAMN04489712_101368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54150">
        <property type="protein sequence ID" value="SEF54150"/>
        <property type="gene ID" value="SAMN04489712_101368"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF54150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="21160" checksum="7E0360712B351B2E" modified="2017-01-18" version="1">MLRVGLTGGIGSGKSEVSARLAARGAVVIDADKIAREVVEPGTPGLSAVVAEFGQEVLLPDGSMDREKVGSIVFADAGRRAALNAIVHPLVGERMQELMAAAPGDAIVVYDVPLLAENGLKEMYDVVVVVDVPEETQLERLTGRRGMTERDARARIAAQASRQDRLAIADHVIDNSGTLRDLDARVEALWADLAERAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SVH0</accession>
    <name>A0A1H5SVH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53918">
        <property type="protein sequence ID" value="SEF53918"/>
        <property type="gene ID" value="SAMN04489712_101360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF53918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="29226" checksum="5CE74D7C56932596" modified="2017-01-18" version="1">MLLEIRDVHVHYGKIAALKGITVEVEEGEIVTLIGANGAGKTTTLKTISGLRPLSSGRILFNGQDISRMPGHKRVLAGIGQAPEGRGIFPGMTVTENLHMGAYARKGDVSKDLAEVFELFPRLAERKNQAGGTMSGGEQQMLAIGRALMSRPKVLLLDEPSMGLAPMLIQQIFTIIEEINRRGTTVLVVEQNAQQALQLAHRAYVLETGRVLKSAPASELLDDPEVRAAYLGGGAGAAGGSGGSGDSGDSGGKAAAVASAPGEAAVVDEPVQKTAPDDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SVI2</accession>
    <name>A0A1H5SVI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54530">
        <property type="protein sequence ID" value="SEF54530"/>
        <property type="gene ID" value="SAMN04489712_101380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="510"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF54530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="563" mass="61114" checksum="914D405B5252FED9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T212</accession>
    <name>A0A1H5T212_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Beta-lactamase</fullName>
            <ecNumber evidence="2 4">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2 4"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56121">
        <property type="protein sequence ID" value="SEF56121"/>
        <property type="gene ID" value="SAMN04489712_101429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023650">
        <property type="entry name" value="Beta-lactam_class-A_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00118">
        <property type="entry name" value="BLACTAMASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00146">
        <property type="entry name" value="BETA_LACTAMASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284562" description="Beta-lactamase" evidence="6">
        <location>
            <begin position="31"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="7">
        <location>
            <begin position="90"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF56121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="329" mass="35498" checksum="B003C337F50F7CA8" modified="2017-01-18" version="1">MRDVHRRWPWRGLGATALAASLLFGGVACGADTEPAGGRAVTHSGQETVRTPAVTGGTEASRQAEARRRLRELEDSYQGRIGAFAFDTGSGRILAHRAHERFPMLSTFKAVAAAAVLHKARREDPGLMDRIVRWSSEDLVDYSPITEQHVDTGLTVAQLCDAAIRYSDNTAGNLLLKQIGGPPGLTRFLRSLGDPVSRLDRWETELNEWSAGERRDTTTPEAMGRDLHRLTVGNGLAEADRRRLIGWLRGNTTGDKRIRAGLPEDWTVGDKTGTAGSAANDVAIAWPPGSSAPVIFAVYTARRDFDAPGDEQVIATTATILARGLGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T3T6</accession>
    <name>A0A1H5T3T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57425">
        <property type="protein sequence ID" value="SEF57425"/>
        <property type="gene ID" value="SAMN04489712_101471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="159"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF57425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="298" mass="32672" checksum="B09E2950762EBC9A" modified="2017-01-18" version="1">MSSVQIRPFVRADRDQLAALVNMHVAAVVPGMSASVQTVLDHLEREPGEFIVDPWVTERVTLVAVRRSRIVAAAHLLRYGAEGKVDETYRGAGEIRWLLCWPDSPDAGDCLALACLAQLARWRVRRRYADGTLPVPGVYGVPRQWPHVRDIYARAGFTVTGRTETVFLAVVGDLPRPGAAPAGPLTARRSLGVNGTRISAVRDGETVGHIEVDTNLGDAARLSRWGGWADVGDLWVAERHRRRGVGTWLMGQAAAWLRLAGVTRLLDYAEAGQDEYAAFLHRAGFIELTRTERGLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T8P7</accession>
    <name>A0A1H5T8P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58357">
        <property type="protein sequence ID" value="SEF58357"/>
        <property type="gene ID" value="SAMN04489712_101501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="220"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF58357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="378" mass="39696" checksum="62CF2BCBC93B469C" modified="2017-01-18" version="1">MDLTFSDEHEELRRTVRSFLEDTSPESEVRRLMESGNGYDPGVWARMGTQLGLQGLAVPEEYGGAGGGALETGIVLEEMGRALLCAPYLATCVLATQAILASSDAGAARELLPGISCGVTVATLAFTEPGRAWNAPASDVTVRRSGGRLLLDGTKDLVLDGALADLVLVTAADEQGTGLYAVAGDAAGLTRTSLNTLDTTRRLARLDFSGTPAHPVGTAGDGPRILARALEHASIALAAESVGGAQRMMELAVEHARTRVQFGRPIGAFQAVKHACADMYIDVESARATAHHAMWTAAESSADLDADLAAAAALAKSCCADAYMRVATETIQVLGGIGVTWEHPAHLYFRRAKSSQLLFGDPTHHRNRLVDHIPAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T8T4</accession>
    <name>A0A1H5T8T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase, N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59164">
        <property type="protein sequence ID" value="SEF59164"/>
        <property type="gene ID" value="SAMN04489712_101525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="186"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF59164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="33170" checksum="4BA94D40783E1B8F" modified="2017-01-18" version="1">MDLTMSADQRDLRAGLRDYLQGTWTPDRLRAAAETPALDRGDWSGLAGLGVFGLTVPEAAGGMGLGLVDAAIVFEELGRALVPGPLVATFLAAGPVPGADDGGAVVTSLDLRDPVLVAEHLDSATHVVAVGDDGLHLWPAEALVAEPAPAPLDPLTPVSRVKTPPVAGERIGSAADAAGWRLRGAVLTSALQVGVAQGALDLAVRYAGERTQFGRVIGSFQAVKHLLADSLVRVDLARAAVWAAALTVDDPEAGDPGEAASAAKVLADDAASQGGRCCVQVHGGMGFTWEVLAHLYLKRAWLQETCFGQADEHARHLAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T8V7</accession>
    <name>A0A1H5T8V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58598">
        <property type="protein sequence ID" value="SEF58598"/>
        <property type="gene ID" value="SAMN04489712_101508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF58598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="27216" checksum="E4758E804D0425B5" modified="2017-01-18" version="1">MTLDKINSQGGDSVTARAVTLPGAPLPPPDEAMVRRSSGEQAALYIRRLIFEGQLRQGDRVPQDEIARALGVSRIPVREALLSLEREGWVTIRPHRGAFIGALDETSVRDHYTLYGLVFGFAARRATERRTPELVTRLTELCEALGGVDDPAAVARLNREFDRVILETAGSPRLRAVLRAMVGIVPGNFFALVPGAIEAVREGARAILRAVRDGDPAGAARAYARMLQRQGDLVAELFTARGLFAAPAQPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TL30</accession>
    <name>A0A1H5TL30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63473">
        <property type="protein sequence ID" value="SEF63473"/>
        <property type="gene ID" value="SAMN04489712_101661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="822"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF63473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="849" mass="90600" checksum="02B9018A82CF83A9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TVK8</accession>
    <name>A0A1H5TVK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66809">
        <property type="protein sequence ID" value="SEF66809"/>
        <property type="gene ID" value="SAMN04489712_101762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF66809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="22640" checksum="F035B29E4E832616" modified="2017-01-18" version="1">MSEAGGSLRERKKQRVYTATAQAAVKLVAERGMQAVRVEDICERAEISRSTFFRYFDSKESCFITGLHYGRLDAVLAALDARPAQEDAFTALCNAFFDITANWRRYREVTRLEARIRAETRTARAHADAELVSWENALATALEARCAGIAPDARPLAPRLVAGVVLCAVRLATERWLEEGAARSPAEKYAEAFAAVRTVIENSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TZB6</accession>
    <name>A0A1H5TZB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Simple sugar transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68090">
        <property type="protein sequence ID" value="SEF68090"/>
        <property type="gene ID" value="SAMN04489712_101804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="256"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF68090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="503" mass="54295" checksum="CF150655A7A65A52" modified="2017-01-18" version="1">MAAPVLEMEGISKGFPGVQALQDVSFRLFPGEVHGLMGENGAGKSTLIKVLTGVHTADAGLVTIDDVDTLIRGPLHAQRLGISTVYQEVNLCPNLSVAENIFIGREPRRFGRIDWKQINRRATELLARLGLDLDVTAQLGSCSLAVQQLIAIVRAVDLKAKVLILDEPTSSLDRGEVARLFSVMRRLKADGVAILFVSHFLEQIYEICDRVTVLRNGGLVGEYPIGELSRLDLVAKMTGQELTALEELDEASPDVVKGERLLALEGVGRTGAIDPVDLDLHAGEVVGFAGLLGSGRSELARLIFGADSADTGVIRTGGGPVALKGPRAAIDQGIAFCPEDRKGDGLIMDLTVEENIILALQVSRGWLKPLSQRKREELVGSYIKALRIHPPHPYALVKNLSGGNQQKVLLARWLITRPKLLILDEPTRGIDIGAKTEIQKLVVSLAGDGMGVVFISAELEEVLRISHKIEVLRDRRLVAELDNDGTLTPEHILQTIANGAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U011</accession>
    <name>A0A1H5U011_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable F420-dependent oxidoreductase, MSMEG_2256 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68339">
        <property type="protein sequence ID" value="SEF68339"/>
        <property type="gene ID" value="SAMN04489712_101813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF68339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="36480" checksum="2178235B7930D921" modified="2017-01-18" version="1">MTGLKITFGPWGETLEEMVAAGRAAEEAGATTLWVPELHRSATVTAAALAQGTSAAKVGTAIALAFTRSPMTTALEALDLDELSGGRFVLGLGTGVKRLNEDWHNARWGRPVAHLRETVAAVRHFVAHAAEGEPMVVEGEYEPMRVRGYQRPFPQVRKEIPVYLAGMGPAMTKLAGQIGQGWISHELCSPAWLAERSLPPLLEGLAASGRDRSELDVVVSACCSVDTDLAAARRRSAGTAGFYASVRTYADFFAFHDLAEEQERVIEAFRAGAGADHLGGAVSPQMTDTLTLTGTFDQVAERISAYAGIADSIKLTPPVHGVGPKDIRAAQAHIIELIRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UT29</accession>
    <name>A0A1H5UT29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78166">
        <property type="protein sequence ID" value="SEF78166"/>
        <property type="gene ID" value="SAMN04489712_1029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF78166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="37389" checksum="DB9A854C3EF38F4A" modified="2017-01-18" version="1">MNRSDNPGPPTAEGGQVILGRFASRTTRTAHGPAIKIVVAVLTPLILALAVLGGVGSFTTVRDMAEPWFGGLAWIVPVGMDVGIFILLAWDLLMEYLALPWPVLRWVAWTFIAGTVTVNVLAAGGDTAGVVMHAAMPVLFVTVVEGVRHLIRQWVGLTTGTRIERIPTARWLLAPLSTGLLWRRMVLWNITAYHQALDLEYQHQLAISRLQQQHGRWAWRWRAPLAARIALRRLPAEPTCRAVLGPSLHEPSGDTPADPEPAQDEQTDERTGGFDEELLAVTRRLIAEANRQGVRPSRANLGRRLRALGFTISNERLIELRAAAGGEAGTHPEDREDRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V212</accession>
    <name>A0A1H5V212_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">Histidine ammonia-lyase</fullName>
            <shortName evidence="5">Histidase</shortName>
            <ecNumber evidence="3 5 7">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hutH</name>
        <name evidence="9" type="ORF">SAMN04489712_102111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5 7">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Cys-Ser-Gly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 5 7"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80748">
        <property type="protein sequence ID" value="SEF80748"/>
        <property type="gene ID" value="SAMN04489712_102111"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00229">
        <property type="entry name" value="His_ammonia_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="2,3-didehydroalanine (Ser)" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="cross-link" description="5-imidazolinone (Ala-Gly)" evidence="5">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF80748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="514" mass="53642" checksum="99D674B469AC0ED2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V6P2</accession>
    <name>A0A1H5V6P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82999">
        <property type="protein sequence ID" value="SEF82999"/>
        <property type="gene ID" value="SAMN04489712_102191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF82999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="160" mass="16657" checksum="4899622D53A9EFCA" modified="2017-01-18" version="1">MSERRRPFTVTAAAVLEGAEGLAALGFGAFVAWETLVGKPLDPVTAWAVTGMALLGGCCMLAVARGLLTAERWSRAPVVLTQLFALPVSWSLLQSEQYAYGVPLITAAVLTLVLVLSNPSTEFLLRAEENDGQEDNGQGNGDSTAAGNGTEAAGGPRHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VGX3</accession>
    <name>A0A1H5VGX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86615">
        <property type="protein sequence ID" value="SEF86615"/>
        <property type="gene ID" value="SAMN04489712_102322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF86615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="30090" checksum="22683A61A6D742D8" modified="2017-01-18" version="1">MGRPPNPIDPNGSFAEHYGWKIRTLREERGWSLEELATKLVCSVSHLSRLERALKAPDKQIARLLDAALDTTYFTEHWLLAVRDRLSSSARSLAEHEAEARVVRAYMPTLVVGPFQTEDYARAIVKAGAYRANVDVIVAERMRRQAVLGRENGPRIQAVMDETALRRRIGGPDVLRAQLERLLEEMIRPNVTIQVVPADVGEYPGLPGGFELLSPAEGSDVAYVEGTTGMGRMVQEPAAISAMHETYDLIRAVALPVNITAQVIKEIRDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VSN1</accession>
    <name>A0A1H5VSN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90309">
        <property type="protein sequence ID" value="SEF90309"/>
        <property type="gene ID" value="SAMN04489712_102444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="274"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF90309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="365" mass="39855" checksum="08667A8A4B0E6131" modified="2017-01-18" version="1">MSSIPRGDDPPRRGRLLRLLRRPAGPQDGPSHRLAGPAADLPAGLSADPPAGLDGGGPRPPGDLSDEADRIPHKPVGAMVFGDHLSLSYNSDEERRAVLTDYVRDGLRADHKIIYMSDDRPAPAVLAWLRDAPGAAGLDLAGAMAGGRFVVRTAEEAYMATGRFDPDEIISLVATEIELALTQGYRGVRVTGEETFCLRGWPGTERFAEFERKIDQVFRTSRVNAMAICQYDRRWFDGPRLRRLESHHMGRVRVNDCFDDGTLRITPTFTPPGLRLAGAIDESTFPAVQEALRAAGGTAGHLCLDLSRLEFCDMAGLRALVGARRSGNGMDRQVILREVPDHLALMLRIAGWDSLPGVYVEEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VTJ8</accession>
    <name>A0A1H5VTJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malate dehydrogenase (Oxaloacetate-decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_102455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90612">
        <property type="protein sequence ID" value="SEF90612"/>
        <property type="gene ID" value="SAMN04489712_102455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="6">
        <location>
            <begin position="93"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="5">
        <location>
            <begin position="238"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF90612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="467" mass="49350" checksum="D00E0A86CEAF971C" modified="2017-01-18" version="1">MATVPSVSYSITVRLEVPAGGRAVSQITHVVENAGGIVTALDVNTAAHESLRIDVTIATRDTEHAEAIVAAIEVIEGVRIHKVSDRTFLMHLGGKIEMRSKVPLRTRDELSMAYTPGVARVSLAIARNPEDVRRLTVKRNSVAVVTDGSAVLGLGNIGPQAALPVMEGKAALFKRFADIDAWPICLDTQDTDEIVRTVQILAPAFGGINLEDISAPRCFEVEARLRELLDIPVFHDDQHGTAICVLAALTNALRVVGKDLSAVRIAMAGAGAAGTAILRLLMHAGARNVVVCDYHGAVHRGRDDLDDSLRWIADHTNAEGYDGDLRGAVKGADVFIGVSAPGILTGDDIATMNDDAIVFALANPEPEVSPDDAREHAAVVATGRSDYPNQINNVLAFPGVFRGLLDAQADEVSQGMLLAAAQALAAVVTDDELGPNYIVPSVFHPDVTHAVAASVREAAGGRPRTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W012</accession>
    <name>A0A1H5W012_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92852">
        <property type="protein sequence ID" value="SEF92852"/>
        <property type="gene ID" value="SAMN04489712_102539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF92852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="59" mass="5944" checksum="EC13ADCAA6F899BE" modified="2017-01-18" version="1">MPKPACEMAGEFAGHERRACHSSPPAHSAGRRTADGGRPGQVSGAADASSAPSIWAVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W2Y9</accession>
    <name>A0A1H5W2Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93862">
        <property type="protein sequence ID" value="SEF93862"/>
        <property type="gene ID" value="SAMN04489712_102570"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="38"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF93862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="18195" checksum="3867594354B0320B" modified="2017-01-18" version="1">MEVAGKRVLDVPDRAELIEGLRLAMQRSTMWTVLLHHATASRAGINMTDAQCINLLVLDGPQTPGRLAQTMGITTGGAITAVIDRLERAGYVKRTRDPQDRRRVIVEPVPETVARLSSYFEPVARAAGDRLAALDDEQLQVLADWFQNWNAMMPAVIEDIQHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W589</accession>
    <name>A0A1H5W589_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CysZ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94655">
        <property type="protein sequence ID" value="SEF94655"/>
        <property type="gene ID" value="SAMN04489712_102593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF94655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="317" mass="33737" checksum="AE5682C56D321E02" modified="2017-01-18" version="1">MVRDPRRSRFHAAYRAGTLRVAGLPEFLDRYGHRAVPRVGRRGNATVSAVSEQRKSGVGDLFIGVGYLLRGFGWVARRPGQWLFGLIPALVVLVLYVVALVWLAGRADDLAGWVTPFADGWSQGPRRAVRAIAAVAIFGAAAFLAVLTFTALTLLVGGPFYEKIAERVEESQGGAPPEPEVPLLTQVGRAIRDTLVLGAVAVGFAVMFFALGFVPVVGQTVVPVAAACVSGYFLAGELTAIALERRGLRRRERFALLRRNRLLVVGFGAATVVTFLIPLGAVIGMPGAVAGGTLLARERLDEGPPVTAGDKSVHGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WE40</accession>
    <name>A0A1H5WE40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97734">
        <property type="protein sequence ID" value="SEF97734"/>
        <property type="gene ID" value="SAMN04489712_102688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF97734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="34308" checksum="8B383EEF6C27689B" modified="2017-01-18" version="1">MSTDPETPADPVHVTIVLPCYNEQDHVIDEVERICKAMDAAGKTYELLAVDDCSTDATLERLREAAPRFPNMRIMAFQHNSGSGTVRRIGTQQARGDIVVWTDADMTYPNERIPELVEILDTDPAVDQVVGARLTEAGTHKVLRVPAKWFIRKVAERLTNTKIPDLNSGLRAFRREVSLPYLRLLPPGFSCVTTITIAFLSNQHPVHYLPIDYYKRAGTSKFHFTKDAYRYILQVLRMVMYFNPLKVLMPPALWLLGIGIAKGVFDMVVHFGYFANNTVMIFITGLLIASLALLADLIVRSRGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WER1</accession>
    <name>A0A1H5WER1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97942">
        <property type="protein sequence ID" value="SEF97942"/>
        <property type="gene ID" value="SAMN04489712_102695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF97942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="564" mass="61356" checksum="030F599FE16D7DE0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WZY8</accession>
    <name>A0A1H5WZY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04795">
        <property type="protein sequence ID" value="SEG04795"/>
        <property type="gene ID" value="SAMN04489712_10323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045401">
        <property type="entry name" value="GAP1-M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045402">
        <property type="entry name" value="GAP1-N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20014">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20013">
        <property type="entry name" value="GAP1-N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAP1-N2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GAP1-M" evidence="2">
        <location>
            <begin position="154"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG04795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="791" mass="83728" checksum="F513FB5A1EB768A3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XGK1</accession>
    <name>A0A1H5XGK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellobiose transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10871">
        <property type="protein sequence ID" value="SEG10871"/>
        <property type="gene ID" value="SAMN04489712_103244"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
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        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289418" evidence="1">
        <location>
            <begin position="28"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG10871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="435" mass="47057" checksum="FC6FB0E73D90D053" modified="2017-01-18" version="1">MGSRRRRGLAGLAAVLAGVLVAGTACGGGDDDGGSADGTITLTVDTFGEFGYDQLFKQYEASHPGIKINSRKVADLDTFKPRLQQWIGTGKGAGDVVALEEGLLPTYMEQRAKFVNLFDHGGASLEQNFLPWKWQMGLSPDGKQLMALGTDIGPLGMCYRKDLFEKAGLPTERDKVTELWPTWDDFLKTGQNFQGKMPKTKFVDGPQALLRVTVLQEAGKGPGYSYFDKSNNLVFDSNPAVRNAFDTVLKFQQAGLTANMQIFTPPWQTALKRDTFATVPCPAWMLGGIEEFSGDYGKGKWDVAGIPGGAGYWGGSWLAVPKQSKHPKEAAELAKFLTSPDGQLGAFKDKNTFPSSPKLYTDAAVAEAKNAYFNEAPVGKIFGDAASQVKPVYLAPKNEDVRQNVENVLVAVAEGKIKPGDAWGRAIEEAKKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XNQ5</accession>
    <name>A0A1H5XNQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12866">
        <property type="protein sequence ID" value="SEG12866"/>
        <property type="gene ID" value="SAMN04489712_103319"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG12866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="17810" checksum="1032909467E1E96A" modified="2017-01-18" version="1">MTYTAVQPGQTGAQQPFGQIGQIGQPYGQMGQIAQYPLLHQLVSNAIQQALSQQGQMGQQPYGPMGQIGQIGQMAQQYPLLYQLVSNAIQQALSQQGQMGQQSYGSMGQIGQPYGQMGQIAQYPLLHQLVSNAIQHILSQQGQMGQQPFGPMGQIGQQPMMTGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YVJ5</accession>
    <name>A0A1H5YVJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28024">
        <property type="protein sequence ID" value="SEG28024"/>
        <property type="gene ID" value="SAMN04489712_104205"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF304"/>
    </dbReference>
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        <property type="entry name" value="UCP026631"/>
    </dbReference>
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        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="UCP026631"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="111"/>
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    </feature>
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            <begin position="149"/>
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        </location>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG28024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="513" mass="54388" checksum="18B7DB7CBBA25874" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z2L5</accession>
    <name>A0A1H5Z2L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30551">
        <property type="protein sequence ID" value="SEG30551"/>
        <property type="gene ID" value="SAMN04489712_104313"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG30551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="31098" checksum="E97EE78777DDDFA6" modified="2017-01-18" version="1">MPPSGSRDAMLIGAATENRKGADFEGKSAAAGPWTVRRSYTQPTSGWPVATFAESTAGPDIGRRASVWSAKPPVTAVSSRSLDARIRSFLRSIPKSHPTFVTIWHEPDAKIRRRLFTLREYKAGFRRFCQLVREVQAEGWHRLYTYQCVTSWAGQRPRPGTTYAEMWPGDGLVDVFAVDGYSSVGTTGGLWGPALEFARSKGVPWAIAEIGWSSPETATPAWLRDQAGYAASHGSGGRSRCAFMCFFDVAGPLGGIPTPGDDAAGQAECRRISAAYHSDYRRFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z402</accession>
    <name>A0A1H5Z402_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoN</name>
        <name evidence="8" type="ORF">SAMN04489712_104336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31048">
        <property type="protein sequence ID" value="SEG31048"/>
        <property type="gene ID" value="SAMN04489712_104336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="136"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG31048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="503" mass="51338" checksum="62D128E3E0C8C232" modified="2017-01-18" version="1">MIQSIDYAAIAPPLIVAVAAIALLLADAFGASRRVLGLVSLGAVGAALVTVIALALGDRRATFCLTGDLRGNGPPSCSYVTDDFTLIFQGVVLAAALVVVLLSLEEITAAGARLPAGEFHFLLLAAIAGALTLVAARDLVLLVVALETLSLPVFALVALRRYDGVASEAALKLFLVSVISTAVMLFGISLLYGVTGAMHLDRVAPALGRVPGDLEPVAAVGVVMVLAGFAFKVAAVPFHFWAPDVYQGAPLPVTAFLSVVSKAAGFAGLTIVVALGLPAYGHVWGPVLGVLAAVTMTLGNLVALRQRSAIRLLAWSSIAQSGYMLAPLAVGDERLPEAVAATVAYVAIYSVMNIGAFAVVIGFRRRAGAPAAGPAPSWDTLDDYRGLARRNPATAAAMAFFLICLAGLPPGVMGLFAKIVVFRATVAGGATWLAVVMAVNTVIALYYYLAWAARLFAAPSGAAEPPRMPRGAAVRAAIGAAAAGAVVLSVAPQLVLQAAAAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z4N8</accession>
    <name>A0A1H5Z4N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31509">
        <property type="protein sequence ID" value="SEG31509"/>
        <property type="gene ID" value="SAMN04489712_104361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG31509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="413" mass="46566" checksum="335DFB7E6ED7FC9E" modified="2017-01-18" version="1">MTIIETTLTFPDPVRPRFYRIRLDGRRLIRTAWSTGRSPRETVKELDVDYDHQAHQVFGSLRDKKMREGFCRVADAADAARGDVVLEFLVPNRCPADAFDLSPDGRTLVVGTMLKEAYGAEIHLVDVATGRRRLVHAEPPGKGQTFLHRVLFDADGERIIYALNGETRLLDPASGRHQVLAAYQQYKDAQFNPFRMRPAWNRDHTRLLVFDHGDRVRVLDREWNTVFETHAEATLFECWDGALSPSGRLLALSRSKGRQYDDSDPMVTEIEVWDLEKGTVRQRIPIPVGQPVNKVGFDPTETLVLACPWYDGGPGAYSLDTTTLAWHFSDPVQPDRWALCYGWDYSPDGTTLAIGRRACTDVVDTATREIDPAFRQSWPETGLTGRTERVRISADGTLVASGGDSGRILIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z553</accession>
    <name>A0A1H5Z553_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein SAMN04489712_104370</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31659">
        <property type="protein sequence ID" value="SEG31659"/>
        <property type="gene ID" value="SAMN04489712_104370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG31659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15942" checksum="460E567D1DE08BB0" modified="2017-01-18" version="1">MPLNRDFIGRSFPPTEPYEVSRVKIREFADAIGDPNPIYRDREAAKAAGHPDVVAPPTFPIVISLGGSAMADPELGLNYAMVVHGEQRFEYVRPVRAGDVLVCETTITEIRSIGNNEKLELRTEIKTAEGEPVCTAYNTIVERGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z6P2</accession>
    <name>A0A1H5Z6P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/cholesterol/gamma-HCH transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31952">
        <property type="protein sequence ID" value="SEG31952"/>
        <property type="gene ID" value="SAMN04489712_104386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG31952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="30267" checksum="4054CE0910AF320E" modified="2017-01-18" version="1">MTTPGIGANQGADQTRESGKGPGRLTKFSDGLVNVAIKEPGRFFALCLDTFRAMFKRPVQWREFIEQSWFIVSVTAIPTMLVAIPFGAILSLQVGGLIRQLGAQSFTGATAVVAIVREASPLVTALLIAGAAGSAMCADIGSRKIREEIDAMEVLGINPLHRLVVPRMLACAFIGLFLNGLVSVVGLMGGYFFNVVLQDGTPGAYLASFNAMAQLPDLIQAEVKAFFFGITAGLVAAYKGLNAKGGPKGVGDAVNQTVVITFMLLFLENFLISALYFQLVPQKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZA18</accession>
    <name>A0A1H5ZA18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine-rich secretory protein family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33142">
        <property type="protein sequence ID" value="SEG33142"/>
        <property type="gene ID" value="SAMN04489712_104442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291392" evidence="2">
        <location>
            <begin position="27"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="163"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG33142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="27724" checksum="00D4E3017BB1BE90" modified="2017-01-18" version="1">MRSPRPRTPRRRALVTAATVTGAALAVSTGVALDRLVLPAFENSGSTTALAQRDPAAGDPAGSAGGTRPGTADVTGHGPAARPAPGRTAQPPEETTPPLKSLRMPTPKKTGDGDKDRDGSGGGSGSSGGSGSGSGSGGGSGSGGGGNTPPPSGLAGLEASVVELTNKERAKAGCPALRVDQRLVTSARGHSADMAAKGYFSHTSPNGDTFADRIKRTGYPSPGAENIAMGYATPAAVMQGWMNSSGHRANILNCGLKAIGVGVQTGSGGPWWTQNFGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZA65</accession>
    <name>A0A1H5ZA65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ORF">SAMN04489712_104454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33409">
        <property type="protein sequence ID" value="SEG33409"/>
        <property type="gene ID" value="SAMN04489712_104454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
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        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
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        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
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        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
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        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
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        <location>
            <begin position="288"/>
            <end position="427"/>
        </location>
    </feature>
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        <location>
            <begin position="460"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="609"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG33409.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="614" mass="66522" checksum="9CDA3C2E7D963592" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZW63</accession>
    <name>A0A1H5ZW63_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">ROK family protein (Putative glucokinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1057</name>
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        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <location>
            <begin position="14"/>
            <end position="59"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG39937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="40665" checksum="41FC070D6697FC98" modified="2017-01-18" version="1">MPSEANGQSIGAGALLAILRDGQARTRAELAQLTGLARSTVSQRLDALMSHRWVVTTEDAISSGGRPAAAFAFNENVRVVLAADLGATHARLAVIDLGMSVLAERAEELPIDRGPEATLDWLVAAFQEMLAETGRDQTQVCGVGVGLPGPVEHASGRPVNPPIMPGWDDFPVPEWLGERLGAPVLVDNDVNIMALGEHWAAGPEVDHLIFIKIGTGIGCGIISDRRLHRGAQGAAGDVGHIRVPSSDALCRCGNIGCLEAVASGASMAAALRAAGVEAQGSRDVVALMRAGDTRAARLIRQAGREVGGVMASIVNFFNPSVIVLGGDIAEAGEQVLAGVRETIYSRSLPLATQHLTIRASELGDRAGVIGAAVMIVEYVLAPETIDQTVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A4W0</accession>
    <name>A0A1H6A4W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43402">
        <property type="protein sequence ID" value="SEG43402"/>
        <property type="gene ID" value="SAMN04489712_105194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292298" evidence="1">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG43402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="19091" checksum="F9613C2C7FA9B662" modified="2017-01-18" version="1">MGSLVRLLALTMAAVFAAACSGPPEPPPGFQRYAGDGYTLAHPAGWREIRTTDEGGAPLVELRGADGPQGAARSQAVVARRDAYTGTMRDQLAQVRLLNQVSGRQVVVDRPADVPGAVEAHRIEAVYDDTAPGGATVRVRIVDVYALTRDGTLLDLAVRAPMVDFDAAGLARVADSLRVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A8D0</accession>
    <name>A0A1H6A8D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44295">
        <property type="protein sequence ID" value="SEG44295"/>
        <property type="gene ID" value="SAMN04489712_105244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="12729" checksum="0B4B7EEE8864750B" modified="2017-01-18" version="1">MTRFLPGEIVNITITGGRIDEVSKNGIHVVLPNGTTATVELSNLEAVTVERVAPAEWPPQPGDLWRTERQPYFAMYSDGAMVLVNLGGERFSPDFVLAHGSLTLVHREEQDGGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AB18</accession>
    <name>A0A1H6AB18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45500">
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        <property type="gene ID" value="SAMN04489712_105306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="210"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG45500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="40019" checksum="E5F5AD1942D7EA8F" modified="2017-01-18" version="1">MGSRDRQARLSAYAAFAVQGLCFATLVTRVPQVQDAHGLSDGALALVLLLVPLIAGVGSVVAGALFARLGSGPVLRVAQPGVCVAVTLVGLTGGEVLPLYAAVALFGLFVGAVDAGMNAQAVAVERRYGVSLLTGFYAVWSVAGILGGLWVALANRLDLTLLAGFVVPSVLGVAVALATGPRLLRKDEEGTGPSAEELKAAARRVPWRPVLVVGAAMGVFYLADAAVSNYSAKYLQDELGAGDYAAPLGYVAYQIAMVASRAAADLAVRRHGGVLIVRLGGLVGLLGMIGVVAAPNAAAAIAAFAVAGLGLAVVAPVAFSAAGRVDPTGLGVAVARLNVFNYVGFVLGAAVVGAVAPLSATDGLRLAFVVPAALVATIVVLARGFAPQPVTAARPATVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AKN7</accession>
    <name>A0A1H6AKN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISPR-associated protein Csx10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48647">
        <property type="protein sequence ID" value="SEG48647"/>
        <property type="gene ID" value="SAMN04489712_105487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG48647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="776" mass="84568" checksum="03D3BEBDA7565F3C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWI2</accession>
    <name>A0A1H6AWI2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52989">
        <property type="protein sequence ID" value="SEG52989"/>
        <property type="gene ID" value="SAMN04489712_10666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG52989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="91" mass="9951" checksum="C60D1552FA9F836B" modified="2017-01-18" version="1">MDRIGAMPLLWMDVSDRAQRRSIQNKPADVGTVRKTRGTSPDGDCVEVGISHMGAIGVRDTKQNGAGPALEFTRPEWAAFLSTIRSADPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWR4</accession>
    <name>A0A1H6AWR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Delta-9 acyl-phospholipid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_10616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52236">
        <property type="protein sequence ID" value="SEG52236"/>
        <property type="gene ID" value="SAMN04489712_10616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="55"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG52236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="37009" checksum="FA5D7EA3BFD46C8D" modified="2017-01-18" version="1">MPARPEPETAGTVAISSGRRTAYLVVLVVLPLLALAAAVGAAWGWGIGPRDVVIAGVMYVISIFGISVGYHRLLTHRSFKCRRPLRVGLALAGGLALQGPVTLWAAEHRRHHKYADRPGDPHSPWAYGEDWPALLRGLAHAHVGWFYTARRRSSRRHWVPDLLADPDIRRLDAAYPAIMALSFLLPATAGGLWSMSWAGFWTAMFWGGLVRYAVVHHVTWSVNSIAHTFGNREFGTRDRSGNVRWVAMLTFGEGWHNWHHAEPTCARHGVLKGQLDASAGLIRCFERAGWAYEVHWPDSRRLAARLAAGLGAGPDAGQVPPPRSVPQGVPRRAPDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B547</accession>
    <name>A0A1H6B547_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4328 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55958">
        <property type="protein sequence ID" value="SEG55958"/>
        <property type="gene ID" value="SAMN04489712_106273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025565">
        <property type="entry name" value="DUF4328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14219">
        <property type="entry name" value="DUF4328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4328" evidence="2">
        <location>
            <begin position="76"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG55958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="227" mass="24072" checksum="F6F01B67F77F5F20" modified="2017-01-18" version="1">MPCALCGDIIPTEVARCPACGAWARRRDFRAIGVAVFMLLGFNAFIALGSGISLLRLDRPLAELTRDGYDAGATGRALAPYADVFTVSAVLAGITGVLYLAWLWRAYRQASGPRPYRSGWVVLGWVVPVINLWLPPRIVHDLWISSGRFSSAGRHAVGAVVTVWWASVLAAIGLAQAFPGGVASLAEARFSVHLGVAATACQALAAALCMVTVFQITRLQVGRPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B632</accession>
    <name>A0A1H6B632_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55855">
        <property type="protein sequence ID" value="SEG55855"/>
        <property type="gene ID" value="SAMN04489712_106265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG55855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="20512" checksum="35501873670D6C73" modified="2017-01-18" version="1">MKTSPDITEPAVGRARTAVPDTAEDVEAGVEAKAAVAGDGPWRRPPGWAWTLPGGPACAREARTVLGQALGALGAPADLIADAQLMVSELATNAYQHAPDQGPYELWLYPHGPQGPGRELRCAIFDGLPDTRLPGYSWTSGDCGRGLSIVRELSGERWGMCRDRSRFGDHPPGKAVWFALPSPVHCPPHFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BD71</accession>
    <name>A0A1H6BD71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, DUF2236 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58708">
        <property type="protein sequence ID" value="SEG58708"/>
        <property type="gene ID" value="SAMN04489712_10714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="35"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG58708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="302" mass="34077" checksum="16C4AFBC2427FA45" modified="2017-01-18" version="1">MGKVHDMDTVRTWDRAPDGTGEEDFGLFGPDSVTWRVMGEPVLMIGGFRALLLQALHPRTMWGTAQNSELMDPRAAWQRLGRTIEFVRVRTYGSLEEVERVGRRVRKLHSKLEGLDLRTGELFQVDDPENLLWVHMGEVDSYLDIARRAGVGLSDADADRFVDEQRRAAQVVGLDPVDVPATVAEMKDYYAQMRSRIWACKDARDGLRRMFNPAVPLPFTPLKLAAPGVATLVVSTLPRWARRMYGLPGLPTSDLAATLTLQAMHRGSQVIPARLRYSPDAKRARRLIHEYTEELKGWEIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJT6</accession>
    <name>A0A1H6BJT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urea transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_107133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60466">
        <property type="protein sequence ID" value="SEG60466"/>
        <property type="gene ID" value="SAMN04489712_107133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017780">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03410">
        <property type="entry name" value="urea_trans_UrtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG60466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="25423" checksum="737504E49823F4D6" modified="2017-01-18" version="1">MLEVTGLEAAYGRARVLFGVDLSVEAGQLMCVMGRNGVGKTTLLNSVMGVLTPTAGKVVFDGRDVTRLPTYERVRLGMGYVPQGHETFPQLTVAENLQVTLEATRHRDRAAVAEALEVFPRLKEMLKRRAGFLSGGQQQQLAIARALVTRPRMLILDEPTEGIQPSIVLEIEQAIERLHKERGLAVLLVEQYLELALRLADGFVILDGGMVRHSGTAADLRDEEVRRLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLA4</accession>
    <name>A0A1H6BLA4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61422">
        <property type="protein sequence ID" value="SEG61422"/>
        <property type="gene ID" value="SAMN04489712_107212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG61422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="431" mass="44534" checksum="1B52D2361FF6C540" modified="2017-01-18" version="1">MRVELVTVGDELLLGDTVNGNAAWLGQRLAEIGAEVTRSVVVGDELDVIIEAVRAALERADAVVITGGLGPTYDDLTRDALAEAAGVPLVRDPELEDRLRAQAARSGRELVPMALRMAEVPKGAGVLPNPAGSAAGLRVELPGGVVYALPGVPHEMRTIMTDTVLPELAAGRTGVRAARRTLRTAGIWESVLAERLAPVEALEGVRLAYLPDPAEVRVRITATGPDAEALLEHAGELARELLGPAVYGQGEESLDRVVHRLLAERAATVAVAESLTGGLLGAELTAMPGSSATYAGGVIAYATRLKHELLGVPADLLAAEGAVHPGVAAAMAAGVRDRLGADYGLAVTGVAGPEPQGGRPVGTVFVAVAGPGSDPVVTAPRLPVPGTGGRVRAPIRRMTVVHALDLLRRVLQGVEIEAGTDTGRQDREDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUV9</accession>
    <name>A0A1H6BUV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64440">
        <property type="protein sequence ID" value="SEG64440"/>
        <property type="gene ID" value="SAMN04489712_10824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011195">
        <property type="entry name" value="UCP010256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010256">
        <property type="entry name" value="CoxE_vWa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="463" mass="51635" checksum="ED87CACA91ADDCBA" modified="2017-01-18" version="1">MASLVDRHTGFVAALRGAGLPVSISEGLDAVRALAVIDLIDREALRAAYAATVVKRPAHRQTFDTLFDLWFPAALGDGVAQGSAARRPDEPDDSPPVPPPLDPEVAERRRELFDLLLTGDDPGLAQFVRAAVGRYGRSPGQRSWFSSGVLNAMSAQTLMAGLLNAVLAGQERGGMAERVARQTFRERIQRFESMVATEVRRRIAEDTDVERAARLAVRPPLEQLDFNRATRADLTALRREVYPLARRLATRLARKHRLARRGRLDFRRTVRASLSTGGVPLTTHHRPRRPHKPELVILCDASDSVASFAHFTLLLTFALREQFTKVRAFAFIDATDEITRFFAPGVDVVDAMTTLAREADLVWITGRSNYGHAIKVFDDKYRDAITPKTSLLILGDARSNYGELSLETLRRLVDQARHAYWLNPEPRRSWDTGDSAATAYGNIVPMYECRNLTQLVEFIEDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BV17</accession>
    <name>A0A1H6BV17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, LacI/PurR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64554">
        <property type="protein sequence ID" value="SEG64554"/>
        <property type="gene ID" value="SAMN04489712_10834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG64554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="35264" checksum="1C3BB27DC3B2063D" modified="2017-01-18" version="1">MVTIADVARHAGVSPSTVSYVLSGKRAISAATRERVAASIKALGYHPHAGARALASSRANVIALVVPLRTDMHVPILLQIAMAIVTAARGHDHDVLLLTNDEGTEGLHRVARSALVDAVIVMDVELHDPRAPVLRELGLPSVLIGFPADPAGLTCVDLDFSAAAGLCVDHLADLGHTGVALIGPPAGVLERGTGFARRTLSGFEEAAARRGLRTLVRPCETAHEAAWATAKELRTEHPEITGLVVHNEPTVPPLLEALRGLDVTVPGDLSIVAMGPQDLSAAVSPRLTMVPIPAEEMGRRAVELLMGKLNGDDRVPGSTLMAPRLMAGDSTAPPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BVW8</accession>
    <name>A0A1H6BVW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">SAMN04489712_10858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64841">
        <property type="protein sequence ID" value="SEG64841"/>
        <property type="gene ID" value="SAMN04489712_10858"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG64841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="28097" checksum="24E48E8F8780D623" modified="2017-01-18" version="1">MAAAKTPSRKPIMAGNWKMNNTHLEAIRLVQQLAFALKEADHEAVEVVVVPPFTAIRSVQTLVDADKLQIGYGAQDVSAHAAGAYTGEISGSMLAKLGCSYVVVGHSERRQYHHEDDALVNAKIKAAYAAELTPILCVGEGLEIRKAGEQVSYTLGQVERALEKIPAEQARSIVIAYEPVWAIGTGEVATPADAQEVCGAIRGRLAELYDAELAAGVRIQYGGSVKSGNIAGIMAQPDVDGALVGGASLDAGEFVKICRYRDLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZY7</accession>
    <name>A0A1H6BZY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66250">
        <property type="protein sequence ID" value="SEG66250"/>
        <property type="gene ID" value="SAMN04489712_108176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG66250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="474" mass="50842" checksum="FFFC89CE1DE3347C" modified="2017-01-18" version="1">MPVLRPPTEPTLVPLPPRAAVLGARTQVLVVGGGPAGLGAALGAAATGARVVLAERHGFLGGNATAALVMPLMSFHNEKRQQVPGDETRLLPTDHGEGEPVVAGVLWRLLERLVAQGGAVSPSVRTGYTVPFDPELFKLVVLDMLDEAGVELLLHSLASGALETPDGRRVVFETKSGPVVIEADVVIDCTGDGDVAAAAGARYEVGRPEDGLVQPMTLMFRMTGFQHARFTSYVREHPDQWRGVHGLWDLIRQATEAGELELSREDMLFFATPHAEEVSVNSTRVTGALGTSVWDLTRAEHQSRRQMEQIARFLRGRVPGFEDAYVVQSGVQIGVRETRRIVGDYRLTGDDVLAARKFDDAVARGAYPVDIHNPDGSGTTLRRVPLGESYDIPLRCLHPAGIDRLMVAGRCISGTHVAHSSYRVMPISMATGHAAGVCAALAAQSGKLPRDVPADAVQRVLREQDASLREDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C063</accession>
    <name>A0A1H6C063_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66330">
        <property type="protein sequence ID" value="SEG66330"/>
        <property type="gene ID" value="SAMN04489712_108183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294289" evidence="3">
        <location>
            <begin position="39"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG66330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="23546" checksum="509EE2EB986129A8" modified="2017-01-18" version="1">MPQQRRLQRIGVRRIGRTATVMSAGTFVLLLAGAPAQAGVTAAKPCPAPKTPAEVPEYWKCLGKNIEDGLNPQPDPQEPEEPKPSKPPAKPKPSKPDPDKPAKPDNDGNGSTPKRTRTPNAPSGGSGGGGVTAYTRPERLRPYTPSAASTAPQLSGLLPAPQVAPGAQVSPTVGLGETRLITPVAAQQRQEDQMLWVAVASGVAGAVGAMNISTWARRMRRRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1A2</accession>
    <name>A0A1H6C1A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66497">
        <property type="protein sequence ID" value="SEG66497"/>
        <property type="gene ID" value="SAMN04489712_108198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG66497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23349" checksum="CD8A1ED1F90107EC" modified="2017-01-18" version="1">MEGDGWPRAVLFDMDGLLIDSEVLWFEVETEVMAWLGGVWGPQHQEKMVGGSLSRAAVYMLALAGPVAPQQEVERRLLDGMAERLSESAPLMPGAKELLAEVRAAGLPTALVSSSHRRLIEAVLEGIGREHFDVTVAGDEVARLKPEPEPYLTAAARLGVRPEDCVVLEDSPTGVAAAEAAGCVTVAVPGVAPVPPAPGRIVVESLREVDLHLLSRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1N8</accession>
    <name>A0A1H6C1N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66852">
        <property type="protein sequence ID" value="SEG66852"/>
        <property type="gene ID" value="SAMN04489712_108230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="60" mass="6539" checksum="CD98839237216C7D" modified="2017-01-18" version="1">MLAIVAAIVFGLALLFDLADIQSDPFDYMTMVTLGLLFLALHLAGVGATSTWRTRGRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1R1</accession>
    <name>A0A1H6C1R1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_108210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66637">
        <property type="protein sequence ID" value="SEG66637"/>
        <property type="gene ID" value="SAMN04489712_108210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="314"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG66637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="364" mass="38593" checksum="3ED027C2EA14C84F" modified="2017-01-18" version="1">MLMGRPFGIPVYVSPSWFLVALVITVMFEGQARHVVASPLSYAVAFVYAVLLYGSVFVHELSHAVTARIFGLPVRSVTLHILGGETAIERESPTPGREFLIAFAGPVVNLVLAGLGLLAELLLPLPPVGRLLVAALTFANLLVGVFNLLPGLPLDGGRLVRAAVWKITGRGGAGTVVAAWVGRGVAVLTLAAGAFLATYPVDGEGIGWVSLLWSALVASFIWVGATHALRAERVRARIPALHARRLARRAALVTADVPLAEAIRRAREEAAGALVIVDHERRPVGLVSERALNAVPEQRRPWLGVGEVSRTLSPELTLPADLSGEALIDALRRAPASEYLLVEPDGRVYGVLAATDIDRAFAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C333</accession>
    <name>A0A1H6C333_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_108273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67293">
        <property type="protein sequence ID" value="SEG67293"/>
        <property type="gene ID" value="SAMN04489712_108273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="227"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG67293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="42403" checksum="E930CEC797990FB0" modified="2017-01-18" version="1">MDFWESDDLAEHREAARAWVEANVRPEWVDEQRRSGCHQTMELHALLARDGILAAGWPPQYGGGDVDPGFAAAVFDECARLGLHFDGWATTVMVLHTVQHVGTEAQKRQYIPAALRGELLIALGYSEPDSGSDVAAAKTTAVRDGAEWVVNGQKMFTSTAQVCSHVFVLARTAPDAPKHKGLSLFLVPTDAPGFEVQPIHTLGGQVTNATFYTGVRVPDTALIGEADQGWSVMRVALVYERGVSSPTSVERTVADDLAAWAREARRPDGTAVLDDPLVAERIGRIAVEEEVSRLLGRWMNWNAAKGGVPGPEGSMRKLFWSEAGQRHFSEALDILGAEGLLAPEAPGAPAGGMFEHDFRNAVVTTIYGGASEVLRDIIAERHLGLPRSRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CBX0</accession>
    <name>A0A1H6CBX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70398">
        <property type="protein sequence ID" value="SEG70398"/>
        <property type="gene ID" value="SAMN04489712_109167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046214">
        <property type="entry name" value="DUF6247"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19760">
        <property type="entry name" value="DUF6247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="11022" checksum="490285A85CB27ED6" modified="2017-01-18" version="1">MSAQPVHYEDPQDPQVIMRDLPPRERELFLQQYQAAARAAAADPGRYQDLRRLLHTYSLIVVAANRPGYYESIQEAKSGVGDAVPLDEALAEELARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CK04</accession>
    <name>A0A1H6CK04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein SanA, affects membrane permeability for vancomycin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73309">
        <property type="protein sequence ID" value="SEG73309"/>
        <property type="gene ID" value="SAMN04489712_11095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="3">
        <location>
            <begin position="116"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG73309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="30520" checksum="B1B43B4A29810915" modified="2017-01-18" version="1">MPTSTDHGPQQPSSGAVRPPRHGCPRVTDGAEAESCRRTSGVRLPAGHGNSPGSTGVPRDVILRRAWRTVKERRLVAPGAVALALLGYGALLPTGWVYASSAPHRASVETVAPAPVALVLGAAAWGDRPSPFLAGRLDVAAHLYRAGKVRAILVTGDNSRKSYDEPTVMWNYLTSQGIPGGKVVRDYAGFDTWDSCVRARRVFGVDRAIVVTQAFHLPRAVALCRAAGVDADGVGHDTMKEYAATTQYGYLREGLASFKALTDIATGRAPRFLGPREPGIHQALRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQY7</accession>
    <name>A0A1H6CQY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75374">
        <property type="protein sequence ID" value="SEG75374"/>
        <property type="gene ID" value="SAMN04489712_11128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="78" mass="9048" checksum="D4F7BF1AAE80663E" modified="2017-01-18" version="1">MGHLYNESIDAETDPSGRLTAYRWRGLRYTVHQVLKAYGPEEDVRVYRVRVSGEDEAVAVAELARDADRWRLRHLFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CR72</accession>
    <name>A0A1H6CR72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75512">
        <property type="protein sequence ID" value="SEG75512"/>
        <property type="gene ID" value="SAMN04489712_11148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="107" mass="11426" checksum="339573E1428FC895" modified="2017-01-18" version="1">MSDPYEVETHAVRVLSALFLQLVRASWPAVKVAFRDAIPRLEVTGPSGVVIDVRMDEDGAQFVFRPSFRRHSIEDVPGAVEAVLTLVRDCGGSLSSDARSAGGGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSB9</accession>
    <name>A0A1H6CSB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_111100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75940">
        <property type="protein sequence ID" value="SEG75940"/>
        <property type="gene ID" value="SAMN04489712_111100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG75940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="413" mass="42167" checksum="1B921E9686BE1B37" modified="2017-01-18" version="1">MASSSAAPVPATTTAGTGRPPHGVLTALCITEITSWGVLYYAFPVLAPAITVDTGWSTPAITAAFSAALVIAALVGIPVGRLLDRHGPHALMTTGSVLATTAVVGLALAPSLAWFAVAWMLAGVAQAAVLYQPAFAALTRYYGPRHLAALTTLTLVAGLASTVFAPLTDALAAHLSWRGVYLTLAAILAAVTIPLHALALRRPWPPPHNHPHHDTTAAHHRTTQVRRITRSRPFWMLAAALTLSAFAMYAVLTNLITLLTTRGATPTTAAWALGLGGLGQVAGRLGYGALTRRTTVRSRTVGILALSAATTAALAVLPGPVVLLVTVAVLAGTTRGIATLLQATAVTDRWGTASYATLSGILAAPTTIAGAIAPWAGAALATTLGGYPALFALLAVIAAIAAVLAIGSCPRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSU6</accession>
    <name>A0A1H6CSU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_111120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76082">
        <property type="protein sequence ID" value="SEG76082"/>
        <property type="gene ID" value="SAMN04489712_111120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG76082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="29220" checksum="7A39E2C2D1A21DF5" modified="2017-01-18" version="1">MTPADKPGALQFEDVSVVAGGRTLVERVSLTVAPGEVVALAGPNGAGKSTLLRTCYRALRPTSGRVRLDGEDVWRTPGRRLARRLAAVPQESTGDFELSAYDVVAMGRTPHKRPFAGDDSDDRDIIMQSLDRLDIAGLAHAPFDRLSGGEKQRVLIARALAQRTGTMVLDEPTNHLDLRHQLDALHLVRGLGVTALIALHDLNLAAAFCDRICVLDGGRTVAVGPPAQVLTAELLAEVYRVDAEVTEHPRTGIPQITVLPGRDGPERSMPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZ99</accession>
    <name>A0A1H6CZ99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EndoU nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78177">
        <property type="protein sequence ID" value="SEG78177"/>
        <property type="gene ID" value="SAMN04489712_11241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029501">
        <property type="entry name" value="EndoU_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14436">
        <property type="entry name" value="EndoU_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EndoU_bacteria" evidence="1">
        <location>
            <begin position="34"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="19245" checksum="355BF24647D220C5" modified="2017-01-18" version="1">MGRRPRGAARGAVRQMGLLKPMEKWLLKRVERPNFQHVFLGNVNHHAQRGTGFHHRYRGKNPPTARVRRDPNGHEIKAQHTPWGAYKARVDVRDENGNWYQKQAWSSFFPDDWTPQQVNEAIGEAFKNSSPDPANPNKWRGVYDGKPIEGFYAGGQRKGWHSAWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5T2</accession>
    <name>A0A1H6D5T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80143">
        <property type="protein sequence ID" value="SEG80143"/>
        <property type="gene ID" value="SAMN04489712_11324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="26639" checksum="F12043081AB5DBEC" modified="2017-01-18" version="1">MELFDLSGKVAVVTGGTRGIGLMMARGLLQAGARVYISSRKPDACAQAATELSQYGQVTPIPADLSTEEECLRLAREIAESEQAVHVLVNNAGATWGAPLEEFPASAWDKVLDLNLKAPFFLTRAFLPLLEAAATADDPARVVNVGSIDGLHVPALPTYSYSASKAGLHHLTRVLARELGPRGITVNAVAPGPFESKMMAATLDAFGEEIAAMAPLRRIGRPDDMAGVAVYLASRAGAYVTGAVIPVDGGLGTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D763</accession>
    <name>A0A1H6D763_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osmotically inducible protein OsmC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80633">
        <property type="protein sequence ID" value="SEG80633"/>
        <property type="gene ID" value="SAMN04489712_113118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019904">
        <property type="entry name" value="Peroxiredoxin_OsmC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03562">
        <property type="entry name" value="osmo_induc_OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="14419" checksum="52181C9A632F9E03" modified="2017-01-18" version="1">MATTRTANAHWEGPLMGGQGTVSLDSSGLGTFDVNWPSRAEKPEGRTSPEELIAAAHSTCFSMALSHGLAGAGTPPETVDTKADVTFQPGEGITGIHLTVRAKVPGLSAEDFQQAAETAKANCPVSKALAGTTITLDASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7J9</accession>
    <name>A0A1H6D7J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Luciferase-like monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81261">
        <property type="protein sequence ID" value="SEG81261"/>
        <property type="gene ID" value="SAMN04489712_11410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_luciferase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG81261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="20099" checksum="E79D75A7206D22EE" modified="2017-01-18" version="1">MSRPGDRQLHFNLHLDPAGHHIAAWRRTGHDLSRYDDIAYDIELVRLAERGRLDSIFIADAPLLLPNTRYRVPLLEPITLLSAYAAATSRIGLIATIVVGLSIAVFPSFARLARSRTLQHADAEYVLAARGLGARRTTILLRELLPVVAPPVSAYAGVIAAVLVLAEAALSFLGLGVVAPIPSWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8M5</accession>
    <name>A0A1H6D8M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81619">
        <property type="protein sequence ID" value="SEG81619"/>
        <property type="gene ID" value="SAMN04489712_11498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24089" checksum="24FBCC84BA4D2FBD" modified="2017-01-18" version="1">MHEAHTPVTVDRAPGIAGELALRRNGPHYEIISNGVFLMDTRDGTSERLLVSTALDHHIAPAHLLIGGLGVGFSLAEATTHPAAGTITVIEREPAVIAWHDTHLRPHSAGALDDPRVHLHRADLLTWLRTTTHTYDAICLDIDNGPDWTVTEGNAELYEPAGLALLTTRLTPHGTLAVWSAAASPAFEQRLRTRFTHVTTHPVPVPHGEPDLIYLARRPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCJ8</accession>
    <name>A0A1H6DCJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_115107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82924">
        <property type="protein sequence ID" value="SEG82924"/>
        <property type="gene ID" value="SAMN04489712_115107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="182" mass="20325" checksum="42E50934DD7404E9" modified="2017-01-18" version="1">MSGHPVLRTERLIMRRWRDADREPFAALNADPQVMEHFPAPLSRAESDALVDRIEAVLDAHGYGFWALEIAATGEFIGMTGLAPVLFDAPFTPAVEMAWRLAPAAWGHGYATEAARRALTFGFAELGLQEIVAITATTNLRSQAVMRRLGMTYDPADDFDHPHLAPGHRLQRHVLYRRQRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF49</accession>
    <name>A0A1H6DF49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83840">
        <property type="protein sequence ID" value="SEG83840"/>
        <property type="gene ID" value="SAMN04489712_11679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="31664" checksum="A90344FBDA196C8A" modified="2017-01-18" version="1">MPELRFDDRVAVITGAGRGLGRAYALLLASRGAKVVVNDPGVSLRGDGVDTGPAEEVVKEVAAAGGEAIACTGSVATAEGGRAVIESALDHYGRIDVLVHNAGIHRPAALAEMTYEDFDAVLDVHLRGAFHVVRPAFPSMCEAGYGRIVLTSSIGGLYGNHKVANYAAAKAGVLGLSNVVALEGAEHGVKCNVIVPAAVTRMAEGIDTSAYPPMGPDLAAPAVGWLAHESCSITGEMLVSIAGRVARAFIAETPGVYRPSWSIEQVGEEIAAIRDTGDPWVLPVVPSAHVDHIRNSFAMAAQGGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL16</accession>
    <name>A0A1H6DL16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85533">
        <property type="protein sequence ID" value="SEG85533"/>
        <property type="gene ID" value="SAMN04489712_11826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="43" mass="4816" checksum="96F52FC3B5C6502B" modified="2017-01-18" version="1">MASALYEPPALTRIGDLREVTLGPKTWGFDYTWQCLFVGCPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLG1</accession>
    <name>A0A1H6DLG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_118133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG86024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86024">
        <property type="protein sequence ID" value="SEG86024"/>
        <property type="gene ID" value="SAMN04489712_118133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="22"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="401" mass="44252" checksum="7906B649A1CD1525" modified="2017-01-18" version="1">MMRGHRPEAVAGAAGGRRLVMIDLLRFVAAFAVVMFHYIGVRPAGIWPVSPRELFPEMTWTWFGAFGVDLFFVISGFVILMSAWGRTPGAFAISRVTRLFPAYWFGVVLCVVVYALTGLEHGYGPKMDGVYERFLPNLTMLQTGVGSPNMEGLYWTLWVELHFYALVTVLAWWGITYSRCVGFMTVWLLAGLFAKEADVTLLETLLIPRWAPYFIGGMALYLVYRYGGNIILWLFVGACWALALRYSLPTSPREPRYWPGVHEYVCVGVVTGIFVVMALVATGHFGWVRWRGLTVLGALTYPLYLVHLTVFRPVVDVLYPEAGRWPTLVVAVAVALASAYLVYRFVEKPGGRLLSRHLKAAAARIREASAPAAPRSEVAAVSGEPDGSRGAASGEPAVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLM6</accession>
    <name>A0A1H6DLM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86200">
        <property type="protein sequence ID" value="SEG86200"/>
        <property type="gene ID" value="SAMN04489712_11916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IclR-ED" evidence="3">
        <location>
            <begin position="64"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="26990" checksum="EE5516190EC275E4" modified="2017-01-18" version="1">MAEGSIARTLRVLEAVCDHGPETLKALSERTELAPPTLLRILRLMADEGYVVQQADRTWRGTMLVWRLGCAVNTSVGLLAISREHTDRLTAALDETSVYAVYEQGAVTYAAHSEPIKPVRAHVRLGQRYRLLAVTTGQAVLAQLDESMVEQALAEQAASGDPRDPEQVRTMLAEIRQRGYAAGPGVRWPDLWGCAAPVFDATGDVIGALGVSIPTARAEQIRDQVVAGVLQEADAMSTRLGRPVVVREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMA4</accession>
    <name>A0A1H6DMA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86319">
        <property type="protein sequence ID" value="SEG86319"/>
        <property type="gene ID" value="SAMN04489712_11952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="299" mass="31204" checksum="D7D39A9CF0D35CE2" modified="2017-01-18" version="1">MEKVDFEGRTVIVTGAGNGIGRAHAFTLAERGARVVVNDLGGAVDGSGSSGAAEAVAQEIRRLGGIATASTDSVATVEGGAALVRRAMNEFGRVDAVIHNAGILRDRTFGRMTDDDITAVLDVHLGGAFNVLRPAWKHMVERGYGRIVLTTSSSGLLGTFGQSSYAAAKAGLIGLMNVLALEGERYGIRVNALSPTAATRMTEGLLGELADRFDPRHVAAVAAYLASEQCDLNRQILTAGGGRVGRIFLGVTPGWYSGPEPASPEDILEAIDEIRSLDDHIVPRSGADEVALIQKVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMR0</accession>
    <name>A0A1H6DMR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86431">
        <property type="protein sequence ID" value="SEG86431"/>
        <property type="gene ID" value="SAMN04489712_11982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1215"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1052"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1164"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG86431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1335" mass="144936" checksum="ABEEDCF2B6CF423F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU25</accession>
    <name>A0A1H6DU25_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_12269</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88739">
        <property type="protein sequence ID" value="SEG88739"/>
        <property type="gene ID" value="SAMN04489712_12269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="12">
        <location>
            <begin position="307"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG88739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="43156" checksum="8EAFEF4FD6E24AE5" modified="2017-01-18" version="1">MTDPFPPSKWEQRFERFAEWVPYLTLGVSLAISLAVPGHPAGTVPATLALAALALAWLIGAHTLLPARLRARRAATVIHFIGVLTTATALSLRDPIFIIYTISGFFLAARFAPSKWTFAAVAATSTVLYGSTIDWLQASVQLLAFHVAIVTLQTLAIGGGHILSIRVEERQRRYRKALVDLEAALEENAGLHAQLMTQAHEAGVLDERQRMAREIHDTLAQGLAGIITQLRAAKRVPDGAEHVELALALATESLAEARRSVDALRPQRLDDAHLPEAMSALARDWSEASGVELHVEITGDRVPLSPAIEVALFRIAQEALTNIGKHAAASRAGLTLSYAGDVTLLDIRDDGKGIDGSGDGGFGLSSMRQRARGVGGTLEIESVPGEGTAISASVPALQAGPQVGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUV7</accession>
    <name>A0A1H6DUV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89137">
        <property type="protein sequence ID" value="SEG89137"/>
        <property type="gene ID" value="SAMN04489712_12328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="220" mass="24766" checksum="90DE2A44BE9EE636" modified="2017-01-18" version="1">MTNSTGAGGVRQRMPYARRREQLLAAALGEFGRRGFHLTQMEHVASAAGVSKALLYQHFTSKEELFSEVTGAIVAELTDRMRTAAASTHSSVEGVRAMVRTLFDYATEEPAGWALVIRHLDKPEVGDDLRGIRDRMGEEFAGLLLRRRRANPALSPAELAANERRARLLAPLMYGSMLSMVSWWLEHPDTPRRKAENMAVEFIWLGLDRLRSGERIRFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DV91</accession>
    <name>A0A1H6DV91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88495">
        <property type="protein sequence ID" value="SEG88495"/>
        <property type="gene ID" value="SAMN04489712_12214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="6512" checksum="1855A7A23AE09633" modified="2017-01-18" version="1">MKIVVDQSKCCGHARCNAFAPDLFELDDLGYVAVSEVEVPAGMEEAAQTGAGACPERAITIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVP0</accession>
    <name>A0A1H6DVP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein SAMN04489712_12352</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89259">
        <property type="protein sequence ID" value="SEG89259"/>
        <property type="gene ID" value="SAMN04489712_12352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG89259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="26676" checksum="BB80377ACF0C5C94" modified="2017-01-18" version="1">MSGHSKWATTKHKKAALDAKRGKLFAKLIKNIEVAARTGGGDPDANPTLYDAIFKAKKNSVPNDNIERARKRGAGEEAGGADWQTIMYEGYAPGGVALLIECLTDNRNRAASEVRTAVTRNGGSMAEPGSVSYLFNRKGVIIVPKNGVTEDDLMLAVLDAGAEEVNDLGESFEVVSEAGDLVAVRSALQEAGIDYESADANWLPSVSVPLDEESAKKVFRLIEALEDSDDVQEVFANFDVSDEVLATLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DW05</accession>
    <name>A0A1H6DW05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ORF">SAMN04489712_12353</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89264">
        <property type="protein sequence ID" value="SEG89264"/>
        <property type="gene ID" value="SAMN04489712_12353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEG89264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="18307" checksum="AC2B244168354E9E" modified="2017-01-18" version="1">MRVLGVDPGLTRCGVGIVDGAPGKPLRLVHVAVLRTSPDEDIATRLLGIETGIEALMAEFTPDAVAVERVFAQHNVRTVMGTAQAGAIAIVAAARRGLPVALHTPSEAKAAVTGNGRADKAQVTMMVTRLLRLEAAPKPADAADALALAICHVWRGGAQARLEAARRAVRQTGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXQ9</accession>
    <name>A0A1H6DXQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89854">
        <property type="protein sequence ID" value="SEG89854"/>
        <property type="gene ID" value="SAMN04489712_12491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="28693" checksum="0218E085FF347D6E" modified="2017-01-18" version="1">MRVLIASEAARPGRDNEDFAAAAPGLGVLIDGAGAPAGLESGCSHSVSWYARTLGGLLLAEAIETKLSLADALAASIERVNALHSGTCDLRHPGSPSATVVAARVVGDRLEHLVLSDSVLVLDRTGADPVVISDDRLAEVNRKLDDPDERPLLGTSEHAAGLLSRVQKHAAYRNRPGGFWVAGTKPEAAEQALTGSTPLDELQAVALLSDGASRLADRFGLMTWPDLLAVLDKSGPAELIARTREAEASDPDGARWPRGKASDDATAVYWALTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY62</accession>
    <name>A0A1H6DY62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR HTH family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89703">
        <property type="protein sequence ID" value="SEG89703"/>
        <property type="gene ID" value="SAMN04489712_12434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="250" mass="28451" checksum="15B7B99E1461EFD4" modified="2017-01-18" version="1">MSKAPARSGQEYRIEELAREAGIPVRTLRYYQERRLLPPPRREGRVAVYSRAHLDRLRLIAELLDRGYRLDGIEELLAAWEQGRDVGELLGFQWAVSAPWSREAETELTMDELAEMFGDQLTPDVLAEAEELGYIRVDGDRVVHRIPRLLEATAALVQEGVPLSAIIAVSWELEAAFDRMAFAFVRMARRHLLDPMGDPPSPAELARLARTVERLRPVARTVADEHFARAMDRRIRKELPDLGNRLDPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZB8</accession>
    <name>A0A1H6DZB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90687">
        <property type="protein sequence ID" value="SEG90687"/>
        <property type="gene ID" value="SAMN04489712_1279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="216" mass="24060" checksum="F23AC5A9C5923C4D" modified="2017-01-18" version="1">MVERPERPERKASVPAVREAGVADVPVLSRVLARAFDDDPVWRWMFPGPRVRLDRMAGLFSIELRHVHLPLGATEVAGRGGRIEAGAMWDPPGRWRTPLPVLIRQFVPLARLFGTRTVPVLRTLTAIEKQHPAEPHWYLSVIGTDPAAQGNGLGGRLLESRLSRCDEEGLPAYLESSKESNVPFYEKYGFRVTRTIRPPGGCPPVWAMWRDPGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZR9</accession>
    <name>A0A1H6DZR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Act minimal PKS chain-length factor (CLF/KS beta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90343">
        <property type="protein sequence ID" value="SEG90343"/>
        <property type="gene ID" value="SAMN04489712_1268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="7"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG90343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="412" mass="42987" checksum="F2D9D91B54444B74" modified="2017-01-18" version="1">MTTATWVTGLAVAAPTGLTVEEYWAATLAGRSAIGPVTRFDASSYPARLAGEITGFAAEEHLPSRLLPQTDRMTQLALAGSDWAFANAGVDPAQLPEFDIGVITASHSGGFEFGQNELRALWSKGGRYVSAYQSFAWFYAVNSGQISIRHGLRGPSSVVVSDQAGGLDAVAQARRQIRKGTPMVISGAVDASLCPWGWVAQLTSGRLSTRDDPGRAYLPFDDDAAGHVPGEGGALLVLESAEHARTRGAGRVYGEIAGYAATTDPRRGSGREPTLRNAIEGALADAGVEPADIGAVFADAAAVPELDRVEAEAIAKVFGPSAVPVTAPKTMTGRLYSGAAPLDLAAAFLALRDGVIPPTINIRPSRRYDLDLVTGAPRAAPLRCVLVVARGHGGLNSAMVVRAVDRPAPPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0G5</accession>
    <name>A0A1H6E0G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90405">
        <property type="protein sequence ID" value="SEG90405"/>
        <property type="gene ID" value="SAMN04489712_12627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7147" checksum="87A5D54E33038979" modified="2017-01-18" version="1">MSPPAAQTSVLDTALVAKSDSLGSGCFLVQVRPLKCQVPAHRLTHTIFQTDPGRPVHTLIKDDHDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0H7</accession>
    <name>A0A1H6E0H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91037">
        <property type="protein sequence ID" value="SEG91037"/>
        <property type="gene ID" value="SAMN04489712_12820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="109" mass="11860" checksum="1332C0A0E2170890" modified="2017-01-18" version="1">MYVAPTPFALAEGTSGQATLIVPAETEIDGRLERVGELVRVETEKIVIGYNFDLQSNVLTPQLAPNPSAGKEHHFAAYRLKGQGRGPVTMKNVEQAKKQLLIEDTNDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0Z4</accession>
    <name>A0A1H6E0Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WXG100 family type VII secretion target</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90666">
        <property type="protein sequence ID" value="SEG90666"/>
        <property type="gene ID" value="SAMN04489712_1273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="89" mass="10085" checksum="CC892A15011C88D5" modified="2017-01-18" version="1">MSDKRGANIAALEDLSRMFSKHSRNLDALIKDLNGRTVSSTEIWWGPSADRFRSAWQEARTAFERMAMALEEGGQDIKRSQQNIEAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1U1</accession>
    <name>A0A1H6E1U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase, Mutator family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91618">
        <property type="protein sequence ID" value="SEG91618"/>
        <property type="gene ID" value="SAMN04489712_1301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG91618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="93" mass="9612" checksum="7F38B2A451C47A80" modified="2017-01-18" version="1" fragment="single">MTNHDEDEPQGGLDVQLAAELVAKAKAEGVSLVGPDGLLAGITKTVLQAALEAEMTEHLGYERGEHPAAPTGNHRNGSSAKTVSTEVGPVQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2H3</accession>
    <name>A0A1H6E2H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91509">
        <property type="protein sequence ID" value="SEG91509"/>
        <property type="gene ID" value="SAMN04489712_12942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="35" mass="3945" checksum="0A4026015378D335" modified="2017-01-18" version="1">MLMAKSRHKKVENVRRYFHSSPEALAEVTSLLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2T8</accession>
    <name>A0A1H6E2T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-ascorbate metabolism protein UlaG, beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91857">
        <property type="protein sequence ID" value="SEG91857"/>
        <property type="gene ID" value="SAMN04489712_1313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="74"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="322" mass="33908" checksum="F08EE6B9977A94D6" modified="2017-01-18" version="1">MKLRFGRPDISRYADRFDVPGADEGLSVTFLGVSTLLVTDGTSAVMTDGFFSRPPLAAVGLRRIAPNRGRIDAALARAGAAALDAVVPVHTHFDHAMDSAVVAARTGARLVGGPSAANVGRGGGLPGDRIVQTTPGEPITCGAFTCTLVESRHCPPDRYPGSITGPVAPPVRASAYRCGDAWSLFLRHTSGRTALVQGSAGFIPGALDGRSAEVAYLGVGQLGIQDEKYVRAYWKETVEAVGARRVVLIHWDDFFRPLDKPLRALPYLGDDLDATMRILGPLAAEQGVPLHFPTVWRREDPWSGLSGTPGGQPPPGAVNAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5L9</accession>
    <name>A0A1H6E5L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92499">
        <property type="protein sequence ID" value="SEG92499"/>
        <property type="gene ID" value="SAMN04489712_13416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="417" mass="43656" checksum="1D9505EADDAE8CB6" modified="2017-01-18" version="1">MMRAAPSQEEVRRHNLGTLLRHIHLRGSASRAELAEGMGLNRSTIMALTSELTAAGVVREELPRDTPRRAGRPSLVVRPESTRVYVLAFDIGVDRLVAARVGLGGVILERREATRPRVPFDPDELVGALAAFTRQLVRRTDRDAVCVGAGAAFSGTVRRADGMIRYGPNLGAIDVSLGNALSRRLGLGLTVSIGNDANLGALAEHRRGIGAGCTDLIYLHGDVGIGGGIIVGGRLLDGVDGYGGEVGHMVVNPSGRRCACGSRGCLEAEIGEHALLANAGRTGAGRVGRDAVRAMVDAAARGDAAARDALHRAGDWLGLGVANLVNVFNPGMVIFGGTLRDIYLGSAAQVRSRLATSTLAAPRERVKLRTAELGDDTTLVGAAELAFSEVLDDPLEVLARLRTTAAGRLPDRSGSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5W1</accession>
    <name>A0A1H6E5W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92275">
        <property type="protein sequence ID" value="SEG92275"/>
        <property type="gene ID" value="SAMN04489712_1332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="29550" checksum="A68FBD4E54FCABD3" modified="2017-01-18" version="1">MSSAGPVPSPSSHTANVARMYDYLLGGRENYAADRQAAEHLLRIAPSSRQLAVINRRFLRRAVRYAAEREGVRQFIDHGSGLPTAENVHQIAQRADPSARVVYVDNDPVVLAHARALLADRDRTTVITADLRRVEEVLGHPDVKQLIDFAEPVAALFVSVLHCIPDSDDPGGLIRRVADRLAPGSLVVLSHLVSTDARMRRRLTEFLHGATGGGWGRVRHPDEIAPWFEGLELVEPGLVEISSWHPEPGDVRQPTTEWIEFGGVARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E721</accession>
    <name>A0A1H6E721_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92746">
        <property type="protein sequence ID" value="SEG92746"/>
        <property type="gene ID" value="SAMN04489712_13518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="18055" checksum="0CC522BA6F12C4FA" modified="2017-01-18" version="1">MTEQAGGTHSRGDEDLRLVLDSFGLILGRWTAVGMQDLILARARVDVDPAMMTILLELDRVGGTARPSHLAQHAHTSKSNVSKVLARLLADGLVDRVTEPDDLRAISITLTPAGRWAADRINETSVAMLTEMMGNWPQNEIHQFAGLLNRFAQSLRSSFLLNDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EC84</accession>
    <name>A0A1H6EC84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000054">
        <property type="protein sequence ID" value="SEG94883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94883">
        <property type="protein sequence ID" value="SEG94883"/>
        <property type="gene ID" value="SAMN04489712_1543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="21036" checksum="8CFBF5A1FD3D0874" modified="2017-01-18" version="1">MNGVGHFDSGRRLGRCASFVLLVCANVPMMATVSAPSPLYPLYRERWGFSVMMPTVIFAVYVAGLLGALLTVGSLSDHPGRRPALVAALLVAAAGTANFWTADGVGALLIARVAQGLAIGTATGALAAGLVEFALGERPRLGPTMTAVGPSVGMAIGAGAVGLLVQATTRPDAYVFPLLTLAFVSLAVVVLATPETHPRRAGGLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECP0</accession>
    <name>A0A1H6ECP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_15018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94716">
        <property type="protein sequence ID" value="SEG94716"/>
        <property type="gene ID" value="SAMN04489712_15018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="76" mass="8290" checksum="EBA009E0FB234E75" modified="2017-01-18" version="1">MIGPQPAGAEQRTRTDLPPVRAITRKRATGLTEEERRLLLAELAEIMAELDELQSRASEIAARVSGPESARLARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S492</accession>
    <name>A0A1H5S492_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44708">
        <property type="protein sequence ID" value="SEF44708"/>
        <property type="gene ID" value="SAMN04489712_10151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF44708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="24967" checksum="92F33CCEACA1B47A" modified="2017-01-18" version="1">MSNNATDAGKSPGRLKQIRMIAQILRQADPKALPIVVGAALGTLVLFVVIGLVFGGLWFFAPLGVLVAVLVGMILFGQLAQRAQYKMIAGQPGAAAAILKSMRGNWTVTEAVNGNRNMDMVHRVVGRPGVILVSEGPSSRVGQLLGAEKKRISRAAQQVPIYDVQVGEEEGQVPVGKLQRHLMKLPRNLNKAQVMELNDRLRALPQKIQMPKGPIPRNVRMPKGPRPKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S5L3</accession>
    <name>A0A1H5S5L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45634">
        <property type="protein sequence ID" value="SEF45634"/>
        <property type="gene ID" value="SAMN04489712_10180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="1">
        <location>
            <begin position="151"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF45634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="29141" checksum="C562C8D2B50ABF28" modified="2017-01-18" version="1">MAGKRRLKRVNRFNRITNHPGLTCLSRLSLTGLRSGFSSRQGAVASALVAGAVATSALTVAAQVPAQAAVGAAAPITALGKTSRVTESLTGVSPQSVGQAQAQTTLALGAPPAKAVRTVSAEDVIRVAESQVGTTEDDLGKSKFGRWYASTQRAKETLERDEGGYDTSVYEGAAWCAMFLAWAAQQAGTDALGADPYTVTYAQSFKDQGRWGTQPKPGAIVFFDWSGGDTIGGIDHVGMVTEVLDDGTVKTVEGNISDSVVSKIRSSNIVGYGYPDYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SL16</accession>
    <name>A0A1H5SL16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51140">
        <property type="protein sequence ID" value="SEF51140"/>
        <property type="gene ID" value="SAMN04489712_101254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="65"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="258"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF51140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="341" mass="36828" checksum="54580B2E4CCF272C" modified="2017-01-18" version="1">MAIGTHGESSVNPPVPARGASRDGGPGLSGLAQVATKIRDAVESVIEGKPRAVRLALTVLLAEGHLLIEDVPGVGKTMLAKALARSIDCSVRRVQFTPDLLPGDITGVSAYNQELREFEFKPGPVFANLVVGDEVNRASPKTQSALLECMEERQVTVDGTTYPLEPPFMVIATQNPVEMEGTYPLPEAQRDRFTARISMGYPDPSAELEMLDVHGQSSPLDRLTPVADAHDVRALIDVVRRVHVAPGVRQYAVDLITATRRHPDLRLGASPRATLQLVRAARAYAALDDRDYVVPDDLQALAVPVLAHRLLPTAEAQVERRMPEQVVAALVDRLPVPGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SLE7</accession>
    <name>A0A1H5SLE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="12" type="ORF">SAMN04489712_101259</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51264">
        <property type="protein sequence ID" value="SEF51264"/>
        <property type="gene ID" value="SAMN04489712_101259"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="120"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="342"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="417"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="417"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF51264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="514" mass="53342" checksum="79D1FEBE47BB70BA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SQ10</accession>
    <name>A0A1H5SQ10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PepX_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="SAMN04489712_101317"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="307"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF52712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="562" mass="61627" checksum="3A9FF43F4B85D39E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SXL1</accession>
    <name>A0A1H5SXL1_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
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        <property type="gene ID" value="SAMN04489712_101402"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PPOX_MSMEG_5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF55249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="113" mass="12198" checksum="EE6D0CC2BB61AE85" modified="2017-01-18" version="1">MDLTEPECAFLSTQRLARLATVDSRGAPQNNPVGFFHDAESGAFVIGGHALGTTRKFRNVLGNPHVALVIDELVSTRPWRVRGMEIRGTAEALTGQEPPAPGLGRELIRVRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T751</accession>
    <name>A0A1H5T751_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase conserved C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57817">
        <property type="protein sequence ID" value="SEF57817"/>
        <property type="gene ID" value="SAMN04489712_101484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="134"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="522"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="952"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF57817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1070" mass="120562" checksum="C77505D5D722A9F7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TGW0</accession>
    <name>A0A1H5TGW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-hydroxybenzoate 3-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62049">
        <property type="protein sequence ID" value="SEF62049"/>
        <property type="gene ID" value="SAMN04489712_101615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018659">
        <property type="term" value="F:4-hydroxybenzoate 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043639">
        <property type="term" value="P:benzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012733">
        <property type="entry name" value="HB_mOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02360">
        <property type="entry name" value="pbenz_hydroxyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF62049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="44096" checksum="6439E57F77C19DB8" modified="2017-01-18" version="1">MRTERTQVAIVGAGPAGLLLSHLLHRRGIASVVLESRSREYVEQRVRAGVLEQGTVDTLVEAGVGERLRREGLPHHGIELRYGGRGRRIAFEKLVPGRRITVYGQQEVVKDLIAARLADGGPIRFEVSGVAVHDLDSAAPSVTYTGPDGEPVRLECDVIAGCDGFHGVTRPSIPDGVLTVYEREYPFAWLGVLARVRPSAEELIYAQTERGFALHSMRSPEVSRFYLQVAPDENLADWPDERIWEELRARLETVPGFTLATGPVIEKGVTPMRSFVVEPMQYGRLYLAGDAAHIVPPTGAKGLNLAVADVRLLTEALVSWFSTGSAALLEGYSAACLKRVWRAQHFSWWMTTLLHTFDSDDAYGRRLQLAHLDYVTTSEAAATTLAENYVGLPYESDPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TWM7</accession>
    <name>A0A1H5TWM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66417">
        <property type="protein sequence ID" value="SEF66417"/>
        <property type="gene ID" value="SAMN04489712_101750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF66417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="198" mass="21443" checksum="908F0EADA34FE91D" modified="2017-01-18" version="1">MYTSGMENESGVRGRTRRAILAAAASVLARDRAATLADIAEAAGVGRSTLHRYFADREELINAVVEDSLTVISQSIDEAALGQGPPLEAMRRLVAAMLDVADRLMFLWGDPRVLDAFDKSSPAEDGSEAAPQSVADLIERGQAEGVFDPEVSVDWIQNVLWAVVYTGVEQVEKGLMPRHGVHATVVRTFENGIRRHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U132</accession>
    <name>A0A1H5U132_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68746">
        <property type="protein sequence ID" value="SEF68746"/>
        <property type="gene ID" value="SAMN04489712_101827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="176"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF68746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="325" mass="34253" checksum="3547D3D5EB441016" modified="2017-01-18" version="1">MGDTGREPLIESVTSAVVGVTDFGPHLDLFCGELGFEVAAEGVVEAADAARLWGAGLGDVEVRLLTAAGSATGRVHLLKVNGPVAPAEHPHTLDVGLAGLNLYTRDIDASYVRLTAAGHPWISRPARYEVPLGEAVVSVTEGYCLGPDGLGLVFVQPANARGTQAWRTDPERHYTELTSVVAHVPDFEAELAFWGPAGLGLSAWYDVTFSSPGIEEMAALPEGTVLRLAFVASAEGGSTRIELTRVESGHRGVDRRGVQRPAHGLGHTGWSVRTEDVDAAVERVAATGGQVVRPPSEVSTPLHGRARVVAVETPNGISVELWQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U397</accession>
    <name>A0A1H5U397_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68888">
        <property type="protein sequence ID" value="SEF68888"/>
        <property type="gene ID" value="SAMN04489712_101832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N_2" evidence="3">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="2">
        <location>
            <begin position="154"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF68888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="34490" checksum="0D59313062CA75E0" modified="2017-01-18" version="1">MTLPSSQRRIVLARRPAGVPHEDDFRAESTEVPQPGPGEVLVRTVDLSLDPYVRGTLTGRDLGHRPIAPGDLVPGRAIARVVDTGEWVVAETGWQEYAAVPAAALSPLSTPSGVPRTAVLSVLGTPGLTAYATVTRLLRPAVDGTVVVSSAVGAVGGTAGQLAALAGARTVAIVGGPEKCRIAVEHFGYTAAVDRHDPSWPRALAAACPNGVDGYLHMGSGAVLDGVMNLISPGGRVVLCGLPDNANEVGTPAVLPAGLLMRTRAVVHGFVVYDHEDLRPRFLREVGGLLAEGRLRLLEDVHEGLESAPAAFRRLMSGENLGKTIVRIAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U3I0</accession>
    <name>A0A1H5U3I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69570">
        <property type="protein sequence ID" value="SEF69570"/>
        <property type="gene ID" value="SAMN04489712_101857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF69570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="16408" checksum="BD3FA21EDFD8E8DD" modified="2017-01-18" version="1">MPTKTAAQQRAQAKRDYDAFLANCPSRQLLDRISDKWVALVLAALGSDGPDRPGDECSGEPRAMRYSELSRRLAGVSQKMLTQTLRSLERDGLLTRTVTPTVPVTVTYELTDLGLSLHHVIRGIKVWAEAHMDEVLANREDYDTRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VEW0</accession>
    <name>A0A1H5VEW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">6-phosphogluconolactonase, cycloisomerase 2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85803">
        <property type="protein sequence ID" value="SEF85803"/>
        <property type="gene ID" value="SAMN04489712_102294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF85803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="41721" checksum="113B9050731D2882" modified="2017-01-18" version="1">MGRTPIDRRHFLGTTGLALGAGGLTWAVAGTALGRVGRPGGPVARRAYIGGFTEGEFGLPDLPGIGLATVDGRTGALSLDGYFRGIDNPTYLALSPRRDVLYAVGQTARGTVHALSIDRRGRLSPINQRPTEGSTPVHLAIDPTGRYLVTVNYDSGGVAVHPLRGDGGLGPLADLAEQTGSGPHPVEQRGPHPHMVAFGTSGDVLVPDKGDDHVYVYGLDPATGRLTLRARSFIGRGVGPRHLAFHPSGRIVYVVNELGHTVAICGYDPRTARLAVLGWASVVPPGVDPRNAPSGVRISPDGRLLFAADRGLDTVTVYRVRDAGRTLRVVESQPVTAKAPGSRWPRDIVLDRSGEFLYAASEKGQSVTALRVAPGTGRLDPVGAPLRIASPSCVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VJ35</accession>
    <name>A0A1H5VJ35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, luciferase family (Includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF87322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF87322">
        <property type="protein sequence ID" value="SEF87322"/>
        <property type="gene ID" value="SAMN04489712_102343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF87322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="32318" checksum="2F1DC6E1791F48E9" modified="2017-01-18" version="1">MTALGVVFRPQFPPERLREVARAADEAGLEELWLWEDCFLESGIASAAAALAWTQRLRVGVGLLPVPLRNVALTAMEAATLHRMFPGRFVLGVGHGVQDWMAQVGARADSPMTLLREHLAALRALLRGERVTTDGRYVKLDGVALDWPPAEAPPVLAGASGPRSLRLSGEAADGTILDASVTPDGVRRARRLIDEGRREGGRTGHHTVVGYLHAATGPDAVARLKAELERWDDASTLELRAAGNADAIAEAVQRLADAGADTVVLQPTADEPDLEGFVRFIAEEVRPLVPQDASSGRGEVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VUM0</accession>
    <name>A0A1H5VUM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90696">
        <property type="protein sequence ID" value="SEF90696"/>
        <property type="gene ID" value="SAMN04489712_102458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF90696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="26957" checksum="B7A6FA3832F74133" modified="2017-01-18" version="1">MIADDSAIVARRMGVRRGGRWLLRPADFDVTGGVVGVAGPPGTGKSTLLATFATLRRPHVGALGILGHDIGNAHSVRAVRARIGYLPDRFSWAQGFTVAEFIAYSAYYKRVPAGTAAAMLERLELGEVAATELALLPPDMRLRAGLAATCVHEPDLVLLDEPLTGLAEPEANALITLIGALAPTVVVTARAIEELTGWCDRLFALGRGRLIEAAAAPPPVASPLATGPVPSVPGPVTPPARAGADGTERSARLAVGTGACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VXJ1</accession>
    <name>A0A1H5VXJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prmC</name>
        <name evidence="9" type="ORF">SAMN04489712_102507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91995">
        <property type="protein sequence ID" value="SEF91995"/>
        <property type="gene ID" value="SAMN04489712_102507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="111"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="119"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="188"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF91995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="31563" checksum="EACC97EEAE045F2D" modified="2017-01-18" version="1">MNLLLDEVARATARLADAGVASPRADAEELAAAVHGVKRSELHTVPDSAFDARFWEGVARREAGEPLQHITGRAFFRFLELKVGPGVFVPRPETEVMVGWALDTLRDMDVQDPLVVDLGTGSGAIALSIAQEAPRARVHAVEKDPKAFVHATRNVEALDERGRVRLHLADFADALGELDGTVDLVVSNPPYIPMSEWEYVPPDVRDHDPAAALWGGGDDGLDAIRVVERTARRLLRPGGHVAVEHSDLQGNAVYWVFAEEHGWRDVRNRRDLTDRDRFVTARLSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X3Q5</accession>
    <name>A0A1H5X3Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06414">
        <property type="protein sequence ID" value="SEG06414"/>
        <property type="gene ID" value="SAMN04489712_10376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="37"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG06414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="320" mass="32488" checksum="1F8C875AC7BE618C" modified="2017-01-18" version="1">MVDGGPGALFGRHPADAHGPAASARTIPAAVLDAVIRQAARTPGKAALIDGTRSLGYRELATLVPATARGLARRGVRPGDLGGVHLDCACDLTLAVHAVAAAGAVPLLLPPGADVAELAGLLVDSQARFLFTSAALSGPALAATERSYVRQVFAFGEVAGATPVAELPVPAPPGEADRPVAGPPHDPALWTPRGRLSHADLLSHISRRAATLQIDGTDVLVAAAAEFARAAETWLGLIHLALAHGATFVAVPGPGGPSLLTTAGRHRATVAVTIPDTLRALAACPTCRPPAGLRVAVIGRPSPQAADTCRRHGWTVVDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X6W2</accession>
    <name>A0A1H5X6W2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07481">
        <property type="protein sequence ID" value="SEG07481"/>
        <property type="gene ID" value="SAMN04489712_103115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="4">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG07481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="132" mass="14090" checksum="108F3990A5947DC0" modified="2017-01-18" version="1">MRHLTVTTRGRDGCAVISLRGELDIASADDLRRGLHAARRAHGDHLILDLDHLEFMDSHGLSVIVNCHKAVTGHGSLALTGARPIVRRTLQITGLDRRLTLYDTVEQATASLHPPAVQAAPSRNSPAGAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X890</accession>
    <name>A0A1H5X890_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07961">
        <property type="protein sequence ID" value="SEG07961"/>
        <property type="gene ID" value="SAMN04489712_103136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG07961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="22703" checksum="2388E3EEC4781C0C" modified="2017-01-18" version="1">MTALEIPAGTVRLEGDLAEVPGSGKVVVFAHGSGSSRHSPRNRRVAEFLNGQGFGTLLFDLLTREEEEMDARTARLRFDIGLLAGRLGQVVAWLREDGSPPAVGLFGASTGAAAALVTAARQPGDVTAVVSRGGRPDLAGPALAAVRAPTLLVVGGQDPQVLGLNEEALAAMDPAAGHRLAVVPGAGHLFEEPGALEEVGRLTARWFREHLPDPSLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XL38</accession>
    <name>A0A1H5XL38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_103303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12442">
        <property type="protein sequence ID" value="SEG12442"/>
        <property type="gene ID" value="SAMN04489712_103303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="29"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG12442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="29991" checksum="4017788DA437EDA2" modified="2017-01-18" version="1">MTTATTAATRPVPLSLDGRVSPGTTVRNVLTLAWRNLVQIKHNPMELIDLSIQPIMFVLLFAYVFGPAIGGTVQDYLPIVIPGIIAQNALFATMTTGFGLNVDVTKGVFDRLRSLPISRIAPLSGRMLADTVKQVWSMAVLLVIGFAIGFRVETGPLHLLAALALLLAFTALFAWASVYIGLAVSEPEKVQIFGFTIIFPITFLSSAFVPISPRAPEVLQFVMRNNPMTHLVEAVRGLLVGDQGGGPVAEHAAISLGWGVLMAAIFIPLSMRAFKRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XPN5</accession>
    <name>A0A1H5XPN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13397">
        <property type="protein sequence ID" value="SEG13397"/>
        <property type="gene ID" value="SAMN04489712_103339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="68"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG13397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="31218" checksum="9C615564368AE547" modified="2017-01-18" version="1">MKIGTPSDTVIAQNRRAWNEVAPRHAEQNFEDTRRHLAADPGHYIDPVFRDHLRSLGLEGKVLAQFNCNNGRELLSAIQLGARSGLGFDFSSEFVRQARRLTAAAQVEAEFVETDIYQVPSRYDATADLLFLTAGALCWMPDLPGYFDAARRVVRPGGQVVLYETHPFLEMFKPDRDRRRDEPLDLHYPYFMDEPVAWDSGLDYYSGEKYGREQVYWYHYTLSDIFQAVIGAGLQIRHFAEFDHDNSIGYREAERFPVRPPMSFILSCERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XYE0</accession>
    <name>A0A1H5XYE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FXSXX-COOH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16370">
        <property type="protein sequence ID" value="SEG16370"/>
        <property type="gene ID" value="SAMN04489712_103454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026334">
        <property type="entry name" value="FxSxx-COOH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04268">
        <property type="entry name" value="FxSxx-COOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG16370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7058" checksum="2D6766CFFA2F9492" modified="2017-01-18" version="1">MDDADGEIESMLIDLGGLSLREIRALDGTVLGEALARVRSEAADPREVVAGFDSNMPPAAAEDVASVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YMG6</accession>
    <name>A0A1H5YMG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24687">
        <property type="protein sequence ID" value="SEG24687"/>
        <property type="gene ID" value="SAMN04489712_10468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG24687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="79" mass="8713" checksum="6E2A63EDE5E23C1A" modified="2017-01-18" version="1">MWDRESIQRETGMATGTVKWFNAEKGFGFIEQDGGGADVFAHYSNIAAQGFRELQEGQKVSYDITQGQKGLQAENIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZDS2</accession>
    <name>A0A1H5ZDS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33807">
        <property type="protein sequence ID" value="SEG33807"/>
        <property type="gene ID" value="SAMN04489712_104471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="43"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG33807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="34905" checksum="863A55BFBDAF14B1" modified="2017-01-18" version="1">MDRVTRSQASVPPLQAPIRPPGGDTLRWVEQCLGPGAEVKMVRPLAGGTWHVNHALLVESRSGSVHRLVLRRWADRDRAATEPEFSPEREIAALALLAGCPIPTPELVAADPAGAYCDAPALLITRLIGHPPGPGADELSEYLIQLAAALLAVHSLSGAATMPPYVPYNRLNVRLPPKHAVRAGLWEQAFELAARPAPEAAPRFIHRDYQPGNTLWSYGRLTGVVDWSAASYGPIAVDIAQMRWSLALRYGPAVADRFLDAFDRVSGGYVHDPYWDLRSVVDLLPEQDGRILDRSLVAPLEDYLTGPLARLGAATGRVREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZHX9</accession>
    <name>A0A1H5ZHX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_104537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35237">
        <property type="protein sequence ID" value="SEG35237"/>
        <property type="gene ID" value="SAMN04489712_104537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG35237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="35933" checksum="A5223978D3FE33B5" modified="2017-01-18" version="1">MTFPEVPQYAQYAGLAVLVVLACCSRPVLWLLSRLAGRLAGRLAPPRQAPRPPPQEAPAGERATVAGRVVQEELQARLAVADRQLREVLVPRTEVRFLDARLPLHEAARSVAASPHSRFPVYRDSHDEVIGFVHVRDLLDPAVSDRRATCVGDLVRPVKYLPASMRVLSVLSQMRRERHHLAIVMDEYGGTAGIVTLEDLVEELIGDIRDEYDVQDAQARRLHGGAVEVDGLLNLDAFAAETGIRLPPGPYETVAGHLMAVLGRVPAAGDAVESAGHRLTVAGMDGRRVARVRVMPLPPPADRGEAPGPGAAPNLSAAGGVPEDDTPRDVASDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZYS5</accession>
    <name>A0A1H5ZYS5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41262">
        <property type="protein sequence ID" value="SEG41262"/>
        <property type="gene ID" value="SAMN04489712_10571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG41262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="31857" checksum="239E2C421A58F4A9" modified="2017-01-18" version="1">MRIDMHSHSTASDGTEPPGTVMRRAHQAGLDVVALTDHDTVAGLPDAAAALPAGLTLVPGMELSCLREGTSVHLLAYLFDPADPALTAECARIRESRETRGRRMVEKLIELGVPVTWEQVRSLAGDAPVGRPHIARAMVAAGTIDDPAQAFTDAWIAPGGRAHAQRYAPDPPAAIRMVRAAGGVPVLAHPRAGRRGQGMSDAQIAELAAAGLFGLEVDHPDHGPADREHLRGLAADLRLAVTGSSDDHGELSGHRLGRETTAPQVYERLLAEATGARPITAPPHRPAHPPAGPGPSGRDMPGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A335</accession>
    <name>A0A1H6A335_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42772">
        <property type="protein sequence ID" value="SEG42772"/>
        <property type="gene ID" value="SAMN04489712_105159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG42772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="28219" checksum="87F5B5BED94C25A6" modified="2017-01-18" version="1">MKPTSKSERTALHGTAWATLALLGLTLAGCGGDDEPRKPSTARTSATPTASTPPPSYSASQVKTRLLTAGEVGDGIYNAPVEFLPFKDRKAPSCSLSGVSLPADPELTFRQYSNRTRQARKEVKYAQLIARFKSPEDATGAYEKLRKRARSCPAKQQVPAKKIRENFTLFPHNDTWRVSEDTIAGWQHLRGTEKQVIPRGYTKHNVLHYMYDYALRGNLVVATAYWERTEPDESGDPAAKRATEVLTRQLRKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A608</accession>
    <name>A0A1H6A608_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43475">
        <property type="protein sequence ID" value="SEG43475"/>
        <property type="gene ID" value="SAMN04489712_105198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG43475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="500" mass="54414" checksum="5E6F64C0874D7A40" modified="2017-01-18" version="1">MDGVGVLAVAVAVVLGLVTAGVNDTVRDGVRRELCKLSPSLGCPGPPGTQPVTMGDPDEPGGACLTNLHSRYGEFTAIGNGRIFSILSDGGTQLQLRRYVNGNGKPDTWQVWDMSWMDVGGGVGIPDKSRLAFLNAGAWATAEGSKAEIYEFDNEKEAREFYKKMENYRIGDPIKVAVRTNPLTGPAHWLAGHLPFGIGDRIGDQIGANEPDRKPAQEYWDGGLYNGFYNDIQLGPLPLSIVGKNFGTTSAGVWRTYAQGDKKENTTFYFQGSQQIMESAEADIDTMIKKAKKRFPNSVQNRISDVERQLADKLGTTMKLPDPVKRAIATDSGVGIGLRGTGSTWIGITVDENGKPVEFTQIDDKQGSWHLRADLDVGPASAWYQNSQEGFRERTTKVLDLTKPEDKAAFDRYLKTSVQPAAATQNPIKPFRDLNQMFLDGAGTMSTVNFDNEVSTFNASIGAVVVGGEWEYDQTTSTATDASYWKPGTGWVKWDKCGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJS7</accession>
    <name>A0A1H6AJS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48781">
        <property type="protein sequence ID" value="SEG48781"/>
        <property type="gene ID" value="SAMN04489712_105496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG48781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="449" mass="50717" checksum="98584E2F3B86F446" modified="2017-01-18" version="1">MSELAWRRLPEQVVAAVIDHPDPRVRRIFAGGHGAPMEHKARLADDPDPKVRRALVGAAVDFGFSVPEGVLEKLLNDPDTGVRREISMLPLPARLRVALARDPDPEIRAKTCVSAWEHLPAGDRNRLLADTDPRVRSEAELAAFGRHPIPVECFDRIPDTYRRESVAQSRMLARDLAERLATHQEARWRSRVAENPHLPVDLVRRLAEDDDSEVRRKVSTHPALTEEERSAIEVGFDPVVRYHLPAWVRARQDDAQFMRACAASSNVLIRRAAACAENLPADVVERLTEDEDYAVRLLLAEHCRQAPASLLLFIWGSWKGLSRHRLRAHPNFPRQGLARFADDPNPRMRELVFFDDQAPAELIHRLSHDENPEARWHALHDARLSLERVIELLQDPDPNLHRGAAADPRLPLETLLELLDDEKLAEPAATNPALPVETMHRLLDRAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AKX1</accession>
    <name>A0A1H6AKX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, TIGR03984 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48675">
        <property type="protein sequence ID" value="SEG48675"/>
        <property type="gene ID" value="SAMN04489712_105489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023815">
        <property type="entry name" value="CRISPR-assoc_A791736"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03984">
        <property type="entry name" value="TIGR03984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG48675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="20948" checksum="AC0F52ED822961F9" modified="2017-01-18" version="1">MNVVLHTAARDGLSFPEVLAYAPDGVALLITPWRYHVALVRDGRVLPHRDEIDLTETFDVRVFNENAELRWLQSGGSGRAVLLTEDATALPADFTERDGDVHAIAVQKGQYLLWGRSVGTSGGWTTLTTERIGAIRVPVDIPRRPGYAALTTREYIARDPRHGNAYVAEERLLGFAPTSITRPRAEDTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AUZ7</accession>
    <name>A0A1H6AUZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52371">
        <property type="protein sequence ID" value="SEG52371"/>
        <property type="gene ID" value="SAMN04489712_10626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="29225" checksum="241B909DE7E96ED4" modified="2017-01-18" version="1">MCESRRRVRASPGDLEVNDLSEPTVRPNETTVPLLPCASVEETLAFYEALGFKATYKQSKPYVYLALQWSGLQLHFGPAPKGLDPAREESGGCLVMVDAVAPYHTAFVTAMRQVYGKVLSSGLPRITRYRPGASRFTLTDPSGNSIIFIQRDEPAELEYGGSKKLTGLARALDNARILREFKQDDRQAFRALKSAVRRHGADASPVEQAIALCHLIDLAIVIDEPTDPWLTDLRGLELTTDDRQRIESELGYLVGLQEWLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AX02</accession>
    <name>A0A1H6AX02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clp amino terminal domain-containing protein, pathogenicity island component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52575">
        <property type="protein sequence ID" value="SEG52575"/>
        <property type="gene ID" value="SAMN04489712_10640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG52575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="129" mass="13896" checksum="600CD2685054CBBB" modified="2017-01-18" version="1">MGGQPAPENVPYSAEARRTLNLALQENPELGPGQIGTDHLLLGLLHEGGFAAGVLAAHSIGYEQVISARDKLRPTLCYGCVEYGVYELDTVTGPETAFPGWLLDLDHQVAPYSSGKRLRSTTRTTSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZW2</accession>
    <name>A0A1H6AZW2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_106137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54118">
        <property type="protein sequence ID" value="SEG54118"/>
        <property type="gene ID" value="SAMN04489712_106137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="121"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG54118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="35454" checksum="8E9BBBDE233AA417" modified="2017-01-18" version="1">MIPRPLDPLRSIKLKLGLLVVASTCVTALVLKEALETGIRGRHAFPFAVLLSLVVTQVLAHGMTSPLRDMTAVAREMARGRYDRRVRASSRDEVGDLARAFNAMADDLAEVDRRRRDFIANVSHELRTPISALHAQLENIADGVTPVRRETLQVALDQTERLGRLVAQLLDLSRVDGGGEPLHRSPFAVRPFLSDAVDQARTAHPQVRFTVEAPPGLTVRADRDRLHQVVANLLDNAARHGRGTVTVTARASRAGLVLEVADDGPGIPPGERDRVFERFSRGDHGSDGGTGLGLAIARWAVDLHGGRIEVVDAARGCRIRALIPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B257</accession>
    <name>A0A1H6B257_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54307">
        <property type="protein sequence ID" value="SEG54307"/>
        <property type="gene ID" value="SAMN04489712_106149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG54307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="169" mass="18004" checksum="4792E7DC10F3776F" modified="2017-01-18" version="1">MTELLPDQVIDEDRFRRALALHAAGVVVVTATSGGAPAGLTATSFSSVSLAPPLVSFYVAHTSTTWPSLRAAQRFAVNILSSGQADLATRFALRGVDRFAAPTRWRPAADGTPLLEGVCAHLLCTPHTTIDIGDHVLVVGRVTGVEVRDPGDPLLYHRGRFGDFHPQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BDT7</accession>
    <name>A0A1H6BDT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58981">
        <property type="protein sequence ID" value="SEG58981"/>
        <property type="gene ID" value="SAMN04489712_10737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG58981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="63" mass="6770" checksum="38B6418FA5EDAE63" modified="2017-01-18" version="1">MGELVAALQQFDPALEVRLAIQPRLPYEHAVGPVAEADGMVWIGEAGQCGYASDEVAESLGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BEG2</accession>
    <name>A0A1H6BEG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59050">
        <property type="protein sequence ID" value="SEG59050"/>
        <property type="gene ID" value="SAMN04489712_10743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039708">
        <property type="entry name" value="MT1774/Rv1733c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42305">
        <property type="entry name" value="PTHR42305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="198" mass="22060" checksum="D2145A0217D5320C" modified="2017-01-18" version="1">MRRPEGGKVPTRLGRLRRRLGFDRNGMRRRIDRVQWAVGLALAAVFLMVAPILATWAGTWSYDRGMRGESHERATRRQVVATVTGPGVASGERYLSQTVQATWRAPDGTPRTGRIPAWKDAGQGARRHLWVDGAGHPTSRPRPHSRTVVDAGYAALGATLAAGLPLLGVYGLVRRRCDRVRDALWDEEWSRIDPHRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BM78</accession>
    <name>A0A1H6BM78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61507">
        <property type="protein sequence ID" value="SEG61507"/>
        <property type="gene ID" value="SAMN04489712_107219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG61507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="65" mass="7116" checksum="A9092CEC877D861F" modified="2017-01-18" version="1">MDSTTAQVTHRLGELSAEFSGWRIGRGGSGHWWAVRGNELVRTRNVDELRARLHELTSSGAPGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUY4</accession>
    <name>A0A1H6BUY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-D-xyloside xylohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64518">
        <property type="protein sequence ID" value="SEG64518"/>
        <property type="gene ID" value="SAMN04489712_10831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="164"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG64518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="778" mass="86986" checksum="03A914B14CB62C05" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZF6</accession>
    <name>A0A1H6BZF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2,3-dihydroxybiphenyl 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_108161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66068">
        <property type="protein sequence ID" value="SEG66068"/>
        <property type="gene ID" value="SAMN04489712_108161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="143"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG66068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="33488" checksum="62E318B0FC3D59AB" modified="2017-01-18" version="1">MIQSLSYIGFSSPGYAEWLTFGPEVLGMQIAGRGDDGTVRLRVDDADHRLVIHPGAEHALAYLGWGVRTPAELAALTARIEEYGLTVHEGGPELAAERRVAGLSWFEDPWGNRHEISWGQFRHPGSFRPGRPMGGGFVTGEQGLGHAVLVVPDMGEANDFFTRILGFRLSDRIIDPPLNAQFYHVNGRHHSLAIAEVPGAAGFQHLMVEVASLDDVGIAYDLCEERDVPIVLTIGRHVNDLMTSFYLYTPAGFHLEYGHGGVVVDDALWEPATYTSTKIWGHRGTRYRDELPFALFNEPKERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZH2</accession>
    <name>A0A1H6BZH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66104">
        <property type="protein sequence ID" value="SEG66104"/>
        <property type="gene ID" value="SAMN04489712_108164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="1">
        <location>
            <begin position="238"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="42453" checksum="85739189A0614F3C" modified="2017-01-18" version="1">MSIVEAVRAAAPVLAEEDAEGARRRRLTEAAWQRLRDTGVLRALQPARWGGGEMPLAEFLNATVEAGRAAPAAGWVTAVVGVHPWQVALFPEETQREIWGEDPARTLASSYTPTGRVERVDGGYRVSGRWSFSSGCLHTDGVILGGIVGKREWNGTQVADFTSVILDRDQYAIEDTWHTAGLAGTGSNDIVVDEVFVPAHRGQSHVDYTYHLGAHLPGRDVNPGPLYRLPWAVVFNAIITAGALGAAQGFVDAWTAETRTRRSNYGGMLRDDVLIQDHLAENQYVVNAGLLKLRNVADELTAVAEAGEWPDREQRARLRYDLARSAQDAGAAVTRLMRASSGRTAYTDHPLHRRYQDVTAAIGHAFLLADPLGQAFAALRLGASNVPAVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZL5</accession>
    <name>A0A1H6BZL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propionyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65875">
        <property type="protein sequence ID" value="SEG65875"/>
        <property type="gene ID" value="SAMN04489712_108145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="62"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG65875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="489" mass="50936" checksum="48166ED88BF86B07" modified="2017-01-18" version="1">MGAYAAAYQRSITDPARFWGLAARDIRWLAPPDRVLDDGAPPFYRWFTGGELNTCDNALDRHVVAGRGDQPALVCPGGDSGPPRAYTYMELTDLVARFAGVLAGLGAEPGDRVLVHLPMTPEAVIAVLACARLGVVHVAPSGGPDADALAAQIDVVRPKVIVSAAEDPAGSAKPVLDAALRLASHKVGHRVILRGPGGTSAVPPRDVDWDEAMAAARPAGCVPVAATDPLHVLFTPGTAGPAKGVVHDNGGYAVALRWSMEHLYGVGPGEVFGATCDLGWPAGLSSAIYAPLLTGCTLLLHEGGGAFLRVIAEHRVKGALTTPATIRALRERDGDRPRGHDLSALEAVFLAGERPDAGACAWASRALGRPVTGQWERPETGRPIAAAPRGLEPVPVRAGVAGPPTPGFDVQALGPDGRPVPPGTDGELGLRLPLPPGALATLWRDDERFVEAHLARYPGYYLTGDVGHLDEDGHVRVTGRAGARDTAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7B4</accession>
    <name>A0A1H6C7B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hydrogenase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_10926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68859">
        <property type="protein sequence ID" value="SEG68859"/>
        <property type="gene ID" value="SAMN04489712_10926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009375">
        <property type="term" value="C:ferredoxin hydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.480.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome-c3_hydrogenase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037148">
        <property type="entry name" value="NiFe-Hase_small_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001821">
        <property type="entry name" value="NiFe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30013">
        <property type="entry name" value="PTHR30013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14720">
        <property type="entry name" value="NiFe_hyd_SSU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000310">
        <property type="entry name" value="NiFe_hyd_ssu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="9">
        <location>
            <begin position="28"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="NiFe_hyd_SSU_C" evidence="10">
        <location>
            <begin position="220"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG68859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="352" mass="37959" checksum="60371B29BE2C669A" modified="2017-01-18" version="1">MTQTAPTADRRVGFEEISILWISEGMSCDGDTVSMTAAGQPGIEDVVNGVIPGLPRVNLHNKVLSPTVGGEEFLAPFRAAVRGDLSPYILVIEGSIPNEKINGDGYWTSFGNDPDTGEPVTLNWWIDALAPGAFAVVAAGTCATYGGIHAMAGNPTGCMGLADYLGWDFRSAGGLPIVNVPGCPIQPENFMETLTWLLYHAAGSAPPPPLDDKLRPQWLFGKTVHEGCDRGSYYEQADFARDYNSPKCQVKIGCWGPVVNCNVPKRGWMGGIGGCPNVGGICIACTMPGFPDKFMPFMDQPPGSSLSALMIKPYGTLIRRLRGITNRTANTEPRWHHNRDVLTSGFNPRYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEE5</accession>
    <name>A0A1H6CEE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71390">
        <property type="protein sequence ID" value="SEG71390"/>
        <property type="gene ID" value="SAMN04489712_109266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="STAS_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG71390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="13097" checksum="419A5DCBB0F8AA4D" modified="2017-01-18" version="1">MDLKVNDYTTDDGLTVINVEGEIDVYTAPKLREKLIDLVNKGKFHLLVDMEKVEFLDSTGLGVLVGGLKRVRAHDGSLELVCTQERILKIFRITGLTKVFGIHDSIEEAQEKRKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CIY7</accession>
    <name>A0A1H6CIY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, OmpR family, contains REC and winged-helix (WHTH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72961">
        <property type="protein sequence ID" value="SEG72961"/>
        <property type="gene ID" value="SAMN04489712_11055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG72961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24474" checksum="979D1D58023BF64E" modified="2017-01-18" version="1">MTVMRVLVVEDEKLIADAIAEWLRREALAVDVVHDGDRALELLAGDDYDVVVLDRDLPLVDGDTVCRSMIESGARARVLMLTAASAVHERVAGLSLGADDYLSKPFAFTELSARVHALARRSRPAAPPVLQRAGIRVDYARREVHRDGRPVPLGNRELALLAELMRAEGAVVSTEELLTRVWDEHIDPFTNIVRVTMLKLRRKLGDPPVIETFPGAGYRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJI0</accession>
    <name>A0A1H6CJI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72933">
        <property type="protein sequence ID" value="SEG72933"/>
        <property type="gene ID" value="SAMN04489712_11052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG72933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="418" mass="44874" checksum="99EC5860228926B5" modified="2017-01-18" version="1">MISLSDEQKLSETMRIAMADVRPPADLAAAGLARGHRMRRRARLLRAGGTVLGLSAIAVAGVSVLGDDSRRTETLTPQVTASSSPATPANPVPHKEVVRIFRGLLPAGGRLTVDPPWPGIGLASVVDGQFDDGKGPAAISLSIRRVSPSEPEAQCVPVQIHPYDDCKATRRSDGSVLVLNKGFTRPQFNTGEKLWYAELSRPGGILIHLGQYNSPEEKHEGGPTRPDPPLTLAQMTSIVTDPAWVRVAARLPAPGQPVGPDLYEEHPGEKLMATLRRLLPAGGRITHPQISDGYVSLIFGDAKGRTTIDVNVQTWRNKDPQSGPSGCRERTKDDPPDASCTKRTLSGGAVVYLQQRAADVVESGVTVRIADVMYPDGLRVVAMVANGTSLKSGPKTRDTPALTLEQLYRLVTDPSWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CL05</accession>
    <name>A0A1H6CL05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_110141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73684">
        <property type="protein sequence ID" value="SEG73684"/>
        <property type="gene ID" value="SAMN04489712_110141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="7">
        <location>
            <begin position="16"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG73684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="368" mass="38174" checksum="5FCB983B47DC3B76" modified="2017-01-18" version="1">MFLALRDLRFARGRFALMGIVVGLIAVLAVLLTGLANGLVNDGVSALRTMPATHLAFEPGVQGNLFSRSSVDPAEARRWSQVPGVREATPYGNTLAHAKEAHTGKDVDIAVFGVEPGSFLAPEPDTGRPLEAGTDGVLVSRKLTDEGIKVGDTLVVERSEVRLPVVGTVGDASYGHVAGVYAPLKTWQRIQYGLPGEPPAAAFEVATAIALDGEPGSGAPDAQVLSVEESYGHSPGYTAEQSTMKMIQFFLYVISMFVVGAFFVVWTVQRKDEIALVRALGGSVGYLVRDAVAQVLVVLVSATVAGAALGAGLVALIMSTAPAMPIALVPGPIVTAMALLIALGVLGAVAALRKITSTDPLLALGGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CL75</accession>
    <name>A0A1H6CL75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_110147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73730">
        <property type="protein sequence ID" value="SEG73730"/>
        <property type="gene ID" value="SAMN04489712_110147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG73730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="35811" checksum="0B04AA704E819D9E" modified="2017-01-18" version="1">MLTPVRKIPQREPEPLAGRLPLRNRAAGLGVLGGLLAVTVVASFAIGAQRIPLDQVVSGLFAPDGSQNALIVQELRLPRTLLGVAVGAALGLAGALMQALTRNPLAEPGLLGVNGGASIAVVLVIGLLKVDEVLVYVWAAFAGAAGAMVLVYLVGSYGRAGATPGRLVLAGAALNAVFSALTSGVMLLEPRTFNGFRFWQVGSLSGRDLETFAQVGPFLLAGAVLALCLARPLNALALGEDAGRALGARPGRTRALGALAVVVLCGGATAAVGPIAFLGLAVPFVVRTLVGPDQRWVLPYSLLLAPVMLLGADIAGRVVAAPGELETGIVTAFLGAPLFVLMVRRARIGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNR4</accession>
    <name>A0A1H6CNR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxybutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74126">
        <property type="protein sequence ID" value="SEG74126"/>
        <property type="gene ID" value="SAMN04489712_110191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003858">
        <property type="term" value="F:3-hydroxybutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011294">
        <property type="entry name" value="3-OHbutyrate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01963">
        <property type="entry name" value="PHB_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG74126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="29410" checksum="6B841265E228CF7B" modified="2017-01-18" version="1">MGGNHKTWEKHGGGGHGGGGVGFVASVAMTHPHAITDLSGRRALVTGGASGIGRACARRLAAAGAHVVIVDIHPEAAEKLAAELGGSAVVADLADLDGLDPLLEVAGTVDVVVNNAGLQHVAPLPEFPAEMFSRLLRVMVEAPFRIVSAALPGMYERGWGRVVNVSSIHGLRASAYKAAYVTAKHALEGLSKVIALEGAPHGVTSNCVNPAYVRTPLVEGQIADQAATHGIPPEQVVEKVMLDRAAIKRLIDPEEVAELVAYLCGPHATMITGTHLVIDGGWTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CS08</accession>
    <name>A0A1H6CS08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75819">
        <property type="protein sequence ID" value="SEG75819"/>
        <property type="gene ID" value="SAMN04489712_11187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="215" mass="23258" checksum="E0F83BDB5FDD5B96" modified="2017-01-18" version="1">MGGAADERREALLARIAASLAPRFDGSLSRQTVEWYVRECHNLLERPSTVGRHLPVLAERFARQRLVALAQSQGLAAKPVPEVLFVCTANAGRSQIAAALTARHAGGRVHVRTAGTCPAGRIDPMVGLALTEIGLDPGMEFPKPLTDEVVAAADVVVTMGCGDACPVYPGKRYQDWLLDEPEDAPLEEVRAIRDHIDERVRELLAELIGLPSARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSL5</accession>
    <name>A0A1H6CSL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75416">
        <property type="protein sequence ID" value="SEG75416"/>
        <property type="gene ID" value="SAMN04489712_11135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="39" mass="4383" checksum="3D7CD19A5F4FFE26" modified="2017-01-18" version="1">MKKLIVLAVIALGGLVVWRRLQQDRAELDLWTEATSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT30</accession>
    <name>A0A1H6CT30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75596">
        <property type="protein sequence ID" value="SEG75596"/>
        <property type="gene ID" value="SAMN04489712_11161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034641">
        <property type="term" value="P:cellular nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046483">
        <property type="term" value="P:heterocycle metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="P:organic cyclic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="1">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="23927" checksum="403E6E5ED13FFE16" modified="2017-01-18" version="1">MGERVADELVARALRESAGRAGENRFLELLEAGAVPAERLRRLAGEEYRIVSSDRRSFALLGARFADGAAGEMFLSLAAGEGQALGLLREFAAALGMGDEELRGYEPHPFAQAYPAFLAQRAAFGTSSEVALAMLANLEEWGAYCGRAAVALRERYGLTEEAVGFFTFFAQAPPGFAEQATEVIAAGLAAGEDPDEALLAARLLHTYETAFWDSLAEGLDDVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVE4</accession>
    <name>A0A1H6CVE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_111204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76767">
        <property type="protein sequence ID" value="SEG76767"/>
        <property type="gene ID" value="SAMN04489712_111204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="184"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG76767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="384" mass="41278" checksum="5E7DB8724879BC7B" modified="2017-01-18" version="1">MIDIRRIPDLWRRLDVTVRDLPLPLLLVAASFVPAFQTHGTQVGDLPARPFDALTVPVILLTCLPLAVRRRWPALCLALVTLGFAADQLRAYHSFAGSALAIALVSAGAHLERRRYTTAAVLSAAYVLLAIALHRLGAPERLDGYVTFYLVTVLAWGIGAWLRSTRAAEAERRRHVAEATRAAERTRIARELHDVVTHHVTAMVVQAEAARYLTAAPDRLDETLSAVTDTGRRAITDLRHLLDLLNPDHGTDARMPSVGELPALVEQTRRAGQPVEFTAAGEPAESAGSAEFVAYRVVQESLTNALKYAHGSRTVVRVHYRDKEISVEVGTDGSGSPAASPGGSGRGLAGLRDRVGALGGDFTADPRPDGGFVVRARIPSGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CY51</accession>
    <name>A0A1H6CY51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase DeaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_1125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG77952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77952">
        <property type="protein sequence ID" value="SEG77952"/>
        <property type="gene ID" value="SAMN04489712_1125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="41"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="243"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG77952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="563" mass="61758" checksum="88BBBF56501F7B79" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYC9</accession>
    <name>A0A1H6CYC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="SEG78159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78159">
        <property type="protein sequence ID" value="SEG78159"/>
        <property type="gene ID" value="SAMN04489712_11238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="314" mass="33932" checksum="74DAD2645CAD3747" modified="2017-01-18" version="1">MFNGRIHSCHLERSRVAGAYVWADDSRPDMSMAEMRQRLVELREQLANGASGPGAGARERSGGDPQGHAETADGLIRVEAAGGRLGAIRLDSRVMRMPSDQLGGLLTETCNAALERAAASAVTADGETAVDFDALARQFQQVHNEGLRQMERMTQGLHDAIQVIRQRAIVRGEVEGGGLERLLEDTARSVEAMRRPAPEPEAEARGPAETERLTAYGLNDLIRVRAESSGTRLGEIGVDERAMRHPSRDIADETVRAANQALRLAREAAMAPMRQAGQDLAATVARLQDASIEQLGTLTESLGRLMGGIDRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4E1</accession>
    <name>A0A1H6D4E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80202">
        <property type="protein sequence ID" value="SEG80202"/>
        <property type="gene ID" value="SAMN04489712_11338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295566" evidence="1">
        <location>
            <begin position="32"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="839" mass="92022" checksum="816ABCCBF7DA2801" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5C4</accession>
    <name>A0A1H6D5C4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_11395</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80510">
        <property type="protein sequence ID" value="SEG80510"/>
        <property type="gene ID" value="SAMN04489712_11395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="114"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="601"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG80510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="686" mass="71648" checksum="44B902BD25C9678E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8W4</accession>
    <name>A0A1H6D8W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81273">
        <property type="protein sequence ID" value="SEG81273"/>
        <property type="gene ID" value="SAMN04489712_11413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="28877" checksum="155583DBCCCE6EDD" modified="2017-01-18" version="1">MPSHGARRVPGLRREEVAVLAGINADYYTRLEQGRERRPSPQVLDALSRALRLDGDARAHLHRLAGTVPEGPAVLVPDQVSPTLRQLMDGYTHTPAFVLNRTLDLLATNTLAYALYSPFHPADNLARMAFADPAGRTFYQDWNRAAQATVANLREAVGYEPDNPRLRELVDTLTRHSTDFARLWAGHSVRGKTHETKMLLHPDVGPLMLHYEALDVRRAPGQQLVIYHAEPGSGSAQALHLLGSIHATRTRQPAPRGADHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8Y7</accession>
    <name>A0A1H6D8Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81574">
        <property type="protein sequence ID" value="SEG81574"/>
        <property type="gene ID" value="SAMN04489712_11487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG81574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="37009" checksum="D5B94E2A3FDFFF7C" modified="2017-01-18" version="1">MTRDEIMLFREARPDVPPYDPHAKAQARARLLAAAGGEAKTTPARQARRRSGPMTTRRRFLAVAALTTGVAVGVTVVQGVELPGGAEPGGSGGRVSLRPVADAEDLAANAALKAAAEPDDRPRPGQWSYVKTVLASSSKGSGGRLFGPPDRRLTIERWTSADGRRIAISQDGGPLEFGEDGPAHGVSPRSDYPYLLSLPTDTGALLAEIHRGIEREGGWPSERRDQRAFEVIEIYLRDVVLPARVRAAMYGALTKIPGVEYEAGAADIVGRPGVTLHLLAEGYLRYEVMIDPRTYEYLGFRYVAVRDHRTQGLDGESHVRKGQILGWGGMAESGIVDEAGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9B5</accession>
    <name>A0A1H6D9B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_114151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81819">
        <property type="protein sequence ID" value="SEG81819"/>
        <property type="gene ID" value="SAMN04489712_114151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG81819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="21757" checksum="9B180FD0E87B1724" modified="2017-01-18" version="1">MPSILAFSALSVVLVIIPGPAVMLVLKSAVARGRGPALLTALGVLAADLVWAGASVAGLTALLVSSQVAFDVVRYLGAAYLVYLGIKLMLTRAAAASPEHGVTPSGAAKSRSRRRAFREGLLSDLSNPKTVIVFTSVIPQFLHHGARPADTLILGAAFAVIGFLSLAAYALVFSAAATMLRDARVTRVILRAGGAILTTFGVGLAIERPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9Q8</accession>
    <name>A0A1H6D9Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-monoxide dehydrogenase medium subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81415">
        <property type="protein sequence ID" value="SEG81415"/>
        <property type="gene ID" value="SAMN04489712_11451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="30384" checksum="7AE4B72AAA9578E6" modified="2017-01-18" version="1">MKPSAFDYHAPTSVAEAVSLLADLGEDAKPIAGGQSLVPMLALRLTALEHLVDLRRVSGLRGIEQRDGAVRIGAMTTQAVIGRSAEVARGVPLLARATPLIGHFQIRNRGTIGGSLAHADAAAEYPAVALALGAQLEAQSPRGRRTIPADRFFTGLWGTDLADDELLTAVAFPRWDGRCGFAIEEFARRSGDFAIAGAAVAVALDDGARIRRCGIGLFGLGPTPLRASAAEAALTRAGLADVTAEDVGRTALADLESVPSDLHGSADYRRHVGAVVVARAWQRAVQEASDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAC8</accession>
    <name>A0A1H6DAC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81655">
        <property type="protein sequence ID" value="SEG81655"/>
        <property type="gene ID" value="SAMN04489712_114109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="937" mass="97769" checksum="029739708F162A89" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAN0</accession>
    <name>A0A1H6DAN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82299">
        <property type="protein sequence ID" value="SEG82299"/>
        <property type="gene ID" value="SAMN04489712_1156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12548" checksum="2E84C06451A60D44" modified="2017-01-18" version="1">MFPRAACWYGTKSGLWLAAPVGAVGLVQAPTAADLARRLTEHYRQHLPYSRPVRPSVPGRPGGSGVAARTSPRPVASRAAAPSRSPDDCVRGRHAARDRRGMWRRGLSRLGLIAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBN1</accession>
    <name>A0A1H6DBN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82564">
        <property type="protein sequence ID" value="SEG82564"/>
        <property type="gene ID" value="SAMN04489712_11544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="99" mass="9879" checksum="8458B96F96B553DD" modified="2017-01-18" version="1">MVAQEHVPYSCVSGEQETGGEVLVGSVVGKTGEDTVAAGGGHGVLAVPDAPPSWVGKPIGELTAGEAIEALAFLGAHRLGDEVLAQVLASVLVRRPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCG8</accession>
    <name>A0A1H6DCG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 6">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 6"/>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82513">
        <property type="protein sequence ID" value="SEG82513"/>
        <property type="gene ID" value="SAMN04489712_11537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="8">
        <location>
            <begin position="5"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG82513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="344" mass="37632" checksum="A4A17AA6DE316EE5" modified="2017-01-18" version="1">MRRVLVTGGAGFIGSHYVRTLLSGTDDLPQVTVLDKLTYAGNPANLDPVEGRFAFVKGDICDAELLAEVVPGHDLVVNFAAESHVDRSILGAAEFVHTNVLGTQTLMQACLDAGTPRVVHVSTDEVYGSIETGSWDERAPLSPSSPYAASKASGDMIALAYHRTHGLPVSITRSGNNYGPYQYPEKIIPLFATNLMDGLDVPLYGDGGNVRTWLHVDDHCKGIRIVAERGEPGEVYHIAGTTELTNRWLTERLLKLLGADWTRVRPVPDRKGHDRRYSLSDAKLRTLGYRPTVDFENGLAETIEWYAANRAWWTPLCLRPPHEATAPPPTETGLNGQQAVGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCY3</accession>
    <name>A0A1H6DCY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioA</name>
        <name evidence="6" type="ORF">SAMN04489712_115138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83074">
        <property type="protein sequence ID" value="SEG83074"/>
        <property type="gene ID" value="SAMN04489712_115138"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="319"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG83074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="440" mass="47128" checksum="FAF5EA5DBF7C52D8" modified="2017-01-18" version="1">MAEHTALPPGEIERLRSYDREHVWHPYGPMPAAVENHPVVAAEGVRLAMADGRTLIDGMSSWWAAVHGYNHPVLNAAVTDQLGRMAHVMFGGLTHPPAVRLAELLVDLTPEPLTKVFFADSGSVSVEVAIKMALQYWRARGRPERHRLLTVRGGYHGDTFGDMSVCDPVNGMHHLFAAVLPRQLFAAPPPGGYDDEPDPAYLDELAALVGRHSGEVAAIILEPVVQGAGGMRFYSPAYLRALRELADEHGLLLILDEIATGFGRSGTFWGADHAGVVPDIMCVGKALTGGYLTMAATLCTDEVARGISEGEGGGLMHGPTFMANPLAAAVACASIELLTGRDGRGRDWRAEVSAIETGLRAGLAETSGLPGVRDTRVLGAIGVIETEQPVDVTAIQKVTMDHGVWLRPFNRLIYTMPPYVCTPDEIAQITTAMVAAARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDF6</accession>
    <name>A0A1H6DDF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82785">
        <property type="protein sequence ID" value="SEG82785"/>
        <property type="gene ID" value="SAMN04489712_11584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="187" mass="20076" checksum="06A26B758A9F6E43" modified="2017-01-18" version="1">MNEQTAIGEAVARTVRSLRASHGWSLDQLAGRAGVSKGVLVALEQGRGNPNLGTLIRISEALGVPLTRLVQVDEEPAVRVLPPERQVVLWRGPDGGTGILLAGSEARPSVELWRWELRPGEPRHSDPHTPGTREIAYVEEGTLTVTVDGRPHSVEAGSAAVFAGDRPHSYSNEGPVTCRFVLTVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFN4</accession>
    <name>A0A1H6DFN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83892">
        <property type="protein sequence ID" value="SEG83892"/>
        <property type="gene ID" value="SAMN04489712_11694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="172" mass="19151" checksum="039E6E196B08D760" modified="2017-01-18" version="1">MPAIFGYVSRDAQLLFADHVGRFYARQYGFPPMAGRLLGFLFVCDPPQQTIDELAEALLASRSAITGAVKLLESYRMARRTRPAGERVDRVSLDPASQQPQNFDSAVHQEHAVLFREGLALLADAPPERRAPLEEMVALAEFLSERLPALLEEWHAHRDELRASGRLPSADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGV5</accession>
    <name>A0A1H6DGV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, luciferase family (Includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83875">
        <property type="protein sequence ID" value="SEG83875"/>
        <property type="gene ID" value="SAMN04489712_11689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="34412" checksum="44BA13AF46894F75" modified="2017-01-18" version="1">MPGDRIIFGAAAIPEPDRDWLAAVERLPVESIWQGGHVLPPGPTGEAITRLALMTAWTERVRVGAAVLLLPLYPPVVVAKQLADLDSRSGGRLTVGVGVGGEFRHEFDAVGVPLAERGPRTDEAMWILRTLWGGGPASHHGAFFSFEDVELRPVCPPAEPGPRMRPGGPPLVVSGRRERAMRRAAHLGDGWLPYLVSPEAYARSVRTIEEEAGAAGRDLAGFEWMMYLYCSIRRDGDRARDDVARFLGSAYGDKPRDMLDRIAPAGTPDQVAARLQAYVDAGVRHFVISPAAHDDTLEVVRLAAEEVLPRLSVPASVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIS3</accession>
    <name>A0A1H6DIS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_117134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85089">
        <property type="protein sequence ID" value="SEG85089"/>
        <property type="gene ID" value="SAMN04489712_117134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23091" checksum="AF8EA8D1BE88204F" modified="2017-01-18" version="1">MSPENGGERSTPAERAVRRRVAALEEAAQSDVRALMEAGLALMIAGDGRRGPRVADIVAAAGLSNDSFYRYFAGKDALVEAIVDQGARTVVGYVRHRIAAVRDPAEQLRVGVAAIMKQVSDADLATKTRAVLGNSTRMAQGSPHVSVMLVDALAELFAAPAAGLGADEPEQVARTIAGTVFAAMQYYLFKEQVPGEDELERLTAFLLAGVRASAGSPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJZ1</accession>
    <name>A0A1H6DJZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_11836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85572">
        <property type="protein sequence ID" value="SEG85572"/>
        <property type="gene ID" value="SAMN04489712_11836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296047" description="Alpha-L-rhamnosidase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="7">
        <location>
            <begin position="198"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="7">
        <location>
            <begin position="383"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="6">
        <location>
            <begin position="495"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="8">
        <location>
            <begin position="609"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="9">
        <location>
            <begin position="964"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG85572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1068" mass="115341" checksum="52FF4517099C4E25" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DK84</accession>
    <name>A0A1H6DK84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="5">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_11857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + 4-hydroxybutanoate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85672">
        <property type="protein sequence ID" value="SEG85672"/>
        <property type="gene ID" value="SAMN04489712_11857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Fe-ADH" evidence="9">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG85672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="428" mass="45412" checksum="E3CCC0A9814AD3BE" modified="2017-01-18" version="1">MHTTPAHAETVFTYGSPALKFGAGASDEIGFDLSRLGVRRVLVVTDAGVAATGHPQRIADQMSGYGIEAHVYDGVRVEPTDASMNEAIDHARGTGPWDAFVAVGGGSSIDTAKAVNLLTTNPGGLMDYLNAPVGAAKPPSQPLKPLVAVPTTTGTGAESTTICVLDVLSLKVKTGISHAWLRPTMAVVDPELTVTQPPEVTASAGMDILCHALESYTARPYTSYERRAPEQRVPYCGSNPISDMWSEQALRLLSRSFRTAVREPENLEARTEMALAATVAGLGFGNAGVHIPHANAYPIAGRVHGYHPPGYPGDGPLVPHGMSVSLTAPEAFRFTFPARPDRHVRAAELLAPGLERPNDPQQHLPAALLNLMRDIGIPNGVGGVGFTEPEIPDLVDGAIKQQRLLSTAPRPVTEDDLAQIFTRSLSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKP2</accession>
    <name>A0A1H6DKP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="9" type="ORF">SAMN04489712_11864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85709">
        <property type="protein sequence ID" value="SEG85709"/>
        <property type="gene ID" value="SAMN04489712_11864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="34"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="254"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG85709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="36306" checksum="959A345593256000" modified="2017-01-18" version="1">MNDSGHDPAATGLVPAGRRSVEPGFSWSGGGGVLRLGTRTSPLAMTQARYVAGRLEELADARVEVVGIQTSGDRHTGHLGELGGKGAFMREIDRALLTGRVDIAVHCLKDVPGDVPRPEGLVFAAYVEREDTADVMLFPMASPVQRLEGLPAGARVGTSAVRRRAQLGRIRPDLRIEYLRGNVNSRLGRLDAGEEFDAVVLARVSLARLGLDRPGEVLDIVPAVGSGVLAIDCRRTDPDIVELARLLDHRPTRQCVTAERTMLHGLRGHCNSPIAGHARFERDGQLSLRGMVFTRDGSRFVHAQEWAPPDKAADLGAYIAGDLLRKGARDLIDGIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKX9</accession>
    <name>A0A1H6DKX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-inositol-3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.250</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="7">GlcNAc-Ins-P N-acetylglucosaminyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mshA</name>
        <name evidence="10" type="ORF">SAMN04489712_11884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:26188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:58892"/>
            <dbReference type="EC" id="2.4.1.250"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase group 1 family. MshA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.250" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85809">
        <property type="protein sequence ID" value="SEG85809"/>
        <property type="gene ID" value="SAMN04489712_11884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01695">
        <property type="entry name" value="MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017814">
        <property type="entry name" value="Mycothiol_biosynthesis_MshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03449">
        <property type="entry name" value="mycothiol_MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="9">
        <location>
            <begin position="26"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="220"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="1D-inositol 3-phosphate binding" evidence="7">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG85809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="435" mass="46300" checksum="5BCA0C129CE0F5BA" modified="2017-01-18" version="1">MSLPIARIATVSVHTSPLDQPGTGDAGGMNVYIVEIAKRLAARGVEVDIFTRATSRELPPVAELVPGVLVRHVVSGPFEELDKSELPTELCGFTSGVLRVEAAHDPGHYDLLHTHYWLSGQVGWAAKQRWGVPLVHSMHTMAKVKNAALAEGDTPEPAARVLGEEQVVDSADRLVANTAEEARQLIDLYGADPDRVAAVTPGVDLSLFRPRAGLLGHRTDAARRRLGLPRDAYVLLFVGRIQPLKAPDVLLRAAARMVEGDPALRGRLLVAVVGGPSGSGRARPERLQKLATDLGIADLVRFEPPCPQAELAEWYRAADVTVVPSHNESFGLVAAESQACGTPVVAAAVGGLCTAVRDGESGVLIDGHDPADYAAVLARLDAEPRLRERLARAAVRHARTLGWDATVDRLLEVYTGAMDAVKQTAQTAQTAGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLN1</accession>
    <name>A0A1H6DLN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85743">
        <property type="protein sequence ID" value="SEG85743"/>
        <property type="gene ID" value="SAMN04489712_11871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="323" mass="33548" checksum="7074349FEAA4ECD7" modified="2017-01-18" version="1">MRGYARKVGILLARLVDDAALLPPAREPMRTALPAYRTAAGHPLLGRFLCPASRLDELRRRLVPEDLIDLGIIADTGVEHLPTALETVRREPRVRLRSVEISPAPDADQARAAAVVIARLPADLPCLIEVRRMPGWRETLDRLAAARGRGVPLGAKLRTVGTGGDGADGRSNGVTEQPADGAAKRRADGAAANGRAGGEHGPSPAEVAAFVVACAERDLPFTCTAGLHRAVRHVDPATGLAHHGFLNIVVAACRARSGASGPGAVDDAVASTDAIALAEEAAGVDDAAARAARELFVAFGSCDIETPRSDLIKLGLAGEGTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLT5</accession>
    <name>A0A1H6DLT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86260">
        <property type="protein sequence ID" value="SEG86260"/>
        <property type="gene ID" value="SAMN04489712_11935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="17"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="479" mass="49366" checksum="E0AB55297C0917E1" modified="2017-01-18" version="1">MTTTTHHHLIAGDTLSTSTTYEVTDPYTEQVIAAVADGDRTAADAAVAAAAEAREAWAATPVETRRRVLGRAGGLLKDRRDELVDLAIADTGARRAVAEETQVDAALARLRHWATLPADLLTVPAEPVVAGLAGTVTRTPVGVVGCISPYNFPLLAMVAKVAPALFAGNTVVMKPAPQDPLLVIALTEALNEALRAEGAPAGAVNLVTGAGAEPGAALVDHPEVGAISFTGSTVVGTEIYRAAAPGMKRLLLELGGKGALIVRADADLDAVVAGATRAWTVHSGQICVTPSRVIVDASVHDELVGRLRTTLGSLVHGDPRDPATTTVPLISEVQRDRVGALVASARAEGGTVHTAANVPDHGYFHPATLVTGVGPETTVMQEEAFGPVVCVTPTSSDDEAVAIANSTRYGLTDQVYSRDLDAARRLAARLAAAQVGINTCARRGDLPFGGNKASGIGRSGGTYALDSYTELRATVYPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMT6</accession>
    <name>A0A1H6DMT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86461">
        <property type="protein sequence ID" value="SEG86461"/>
        <property type="gene ID" value="SAMN04489712_11989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="646"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="875" mass="92253" checksum="E2DB27F85F562F9E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNJ4</accession>
    <name>A0A1H6DNJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline iminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86808">
        <property type="protein sequence ID" value="SEG86808"/>
        <property type="gene ID" value="SAMN04489712_1202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="31383" checksum="451D655B5C6470D8" modified="2017-01-18" version="1">MRIQVDDVHLYFDVDGPALVPDGPGMAERPTIVTLHGGPGADHSSFKPIFAAAAEFAQIVYFDQRGSGRSDHADARSWTWERWADDVIGLCDALDIADPVLLGTSSGGWVALTAALRHPDRISRLVLDSVMPGPTEERLAVFERLGGAEAREVARRYWAGESTDEIRQAWRNVCLPLYSRRPDGDPDAADRLRRIVWNDDVLEHFRHSLAARFDPWDQLGAITCPTLVLAGEDDPVATAPAARRLADALTGCPVRLHVLPDVGHGVFRETPAHAFELLRDFVTGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNT2</accession>
    <name>A0A1H6DNT2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">obg</name>
        <name evidence="11" type="ORF">SAMN04489712_12013</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
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    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86831">
        <property type="protein sequence ID" value="SEG86831"/>
        <property type="gene ID" value="SAMN04489712_12013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="G_OBG"/>
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        <property type="entry name" value="GTP-bd"/>
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        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="OBG_GTPase"/>
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        <property type="entry name" value="OCT_dom"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
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        <property type="entry name" value="SSF102741"/>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="163"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="360"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
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        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="194"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
    </feature>
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            <begin position="215"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
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            <begin position="322"/>
            <end position="324"/>
        </location>
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            <name>GTP</name>
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        </ligand>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="SEG86831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="463" mass="48652" checksum="20E337CD0E09A12D" modified="2017-01-18" version="1">MAAGAQFVDRVVLHIAAGNGGHGCASVHREKFKPLGGPDGGNGGRGGDVILQVDNGTASLLDYHRRPHRRAGNGKPGQGSHRNGADGDDVVLPVPDGTVVLTPGGEVLADLVGEGTRFVVAQGGRGGLGNAALASTKRKAPGFALLGEEGEQHDIVLELKSVADVALVGFPSAGKSSLIAALSAARPKIADYPFTTLTPNLGVVAAGDVTFTVADVPGLIEGASEGRGLGLEFLRHIERSSTLVHVLDCATMEPGRDPVSDFEVIEAELRAYDRELGDDIRPLSDRPRLVVLNKIDVPDGRELADLVRPEFEGRGLRVFEVSAATHEGLRELSFAMAEMVAAHRATLPAPEPTRLVIRPEPVGGGADFTVRTLGDNTYLIGGDKPRRWLRQTDFNNDEAVGYLADRLARLGVEQALAEAGAEPGATVMIGTEDDAVVFDWAPEITTGGEGQGPRGTDRRLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNZ7</accession>
    <name>A0A1H6DNZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Decaprenylphospho-beta-D-ribofuranose 2-oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_119100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ALO_C"/>
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    </dbReference>
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        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG86513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="441" mass="46230" checksum="2BBDCD7776BEC9B4" modified="2017-01-18" version="1">MTESRMLTGWGRTAPSAARVITGADDEALIAAVLGAGPRGLLARGSGRAYGDVAQNAGGVIVDMTRRARIVSWDARQGVVTVESGVTLDRLLRTVVPAGWCLPVIPGTGHVTVGGAIAADVHGKNHGSQGGFGAHVLAFDLLTGNGSVRTATPGSEVFQATVGGMGLTGVVLRATLRLIPVTTAWVRVTRQRAGRLDSVLAGLMTADHAVAWLDLSRTGARTGRGVLTLGSPAEPDELPPGTDPLAYAAVRSSPALAVPVSPLFRPQVIGAANSVIYRRAPSVPRSVARPMADYFFPLDRVIAWNRAYGRGGFVQYQFVLPHDAAETLHRVITMLASADRGVSLAVLKRLGPGGSGLLSFPTAGWTLAADLPACTALADRLDRLDRLVAGAGGRVYLAKDARLRPDVLTAMYPKLARFRAVRRALDPAGIFTSDLARRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP51</accession>
    <name>A0A1H6DP51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86315">
        <property type="protein sequence ID" value="SEG86315"/>
        <property type="gene ID" value="SAMN04489712_11951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="18179" checksum="E3715673DB33E64B" modified="2017-01-18" version="1">MPVSEVHHVAITVSDLDRAADFYEKALGYKKTLRTDVGGPGIEESLGLPKGTTGKVQYLQGPTQIGQLELIEWNGTKKRTATAGHLELGTFLLSFQVPRDEIAEVHQRLVDLGAECIRPPQRVLLENYGYITAFAARDLDGNLLEFVSLPSREEILAFRSGEDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DR95</accession>
    <name>A0A1H6DR95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-methylhydantoinase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87801">
        <property type="protein sequence ID" value="SEG87801"/>
        <property type="gene ID" value="SAMN04489712_1214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase_B" evidence="1">
        <location>
            <begin position="9"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="731" mass="77675" checksum="F41765C81C1B4CB6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTP0</accession>
    <name>A0A1H6DTP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, FadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88638">
        <property type="protein sequence ID" value="SEG88638"/>
        <property type="gene ID" value="SAMN04489712_12249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="266"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG88638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="485" mass="52089" checksum="FA4E93ACF1FC4FE0" modified="2017-01-18" version="1">MTLLGGHASAAVSGDGRKEKLGEQVARRIEDDIVARGWPVGEVLGSEAELTARYGVSRAALREAISILEYKQVAAMRRGRGGGLVVRAPAAAVVAEAVAAFFHFADVSADELYEARITLEVLAARLAARRIEESDIAALREVTATDTPERPLSVAIARVAGNPVLTIFIPTLTRVTGALAVGPAGRTDGFALGEGVKAERDRALTAIAEAVISGDEATAERRVRTHLLGERAWLERVLADQAESRARAVAEQPDSLAERLARSPVGKLPERIALLIRQEIHQRGWPAGEVIGGEAALCEELGVSRAVFREAVRILEHNGVARMRQGPGGGLVVLTPDPARVVDALALYLRYLRVGAADLFEVRTAVELKAVELAAAVNGRDAAGAERLAESLEHERVHSDAPPAYADLHVALAQLSGNRLLTLFTAVLSRLTPFRLPRDDVHQRRSLQTHEKIAEAVLSGDASLARHRMSRHLEALTPWLDDSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DW11</accession>
    <name>A0A1H6DW11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_122106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88916">
        <property type="protein sequence ID" value="SEG88916"/>
        <property type="gene ID" value="SAMN04489712_122106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="22191" checksum="DD3EE79D5ED6621E" modified="2017-01-18" version="1">MTKETDSTRDRLLTAAEHLFLEKGADQVSIRAINAAAGLNPGAVHYHFGSREGLVSALLERELLPLWADRLEVIAGRSQAGEPFEVAELVAAIVEPFEELSRTEKGRMLCHLLARLVQPAWRLPHVSPWFGSAPFEVMLGRAMPELSVREVAERWRLAFTLLLEIYGRSLSPAPTTAVSLPQTETVIVFITAGLTAPSPKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWN1</accession>
    <name>A0A1H6DWN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89133">
        <property type="protein sequence ID" value="SEG89133"/>
        <property type="gene ID" value="SAMN04489712_12327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="281"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="689"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG89133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="784" mass="84267" checksum="8FDD407DD633C4E1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYM1</accession>
    <name>A0A1H6DYM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90460">
        <property type="protein sequence ID" value="SEG90460"/>
        <property type="gene ID" value="SAMN04489712_12644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="25900" checksum="E918446109EFAE21" modified="2017-01-18" version="1">MSEPKVVVVTGGGDGIGRTIVNHLAAEGWSVCVADIDEEASQRAASELTEAGHRVIGVRADVSCESDVKRIGEVAESELGPLTAWINNAGNTRPAMLIKMEADAFDDVMSVHARGTFLGIREAARRMVATGTAGVIVNVTSLAGLGGTIGQINYSAAKGAITAMTKSAAKELGRYGIRVNAVAPSAATKMTRTIMNDPKFAKTYLAKIALGRFAMAEEMAPTFGFLLSEGASYLTGQVVSVDGGTYLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E051</accession>
    <name>A0A1H6E051_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90841">
        <property type="protein sequence ID" value="SEG90841"/>
        <property type="gene ID" value="SAMN04489712_12754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG90841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="389" mass="41718" checksum="4453338A4C99E3D9" modified="2017-01-18" version="1">MSSDFPAYAPSEEHELLRQTVRELAEAKIAPHAAEVDETGEFPQNALDALVAGDLHAVHVPESYGGAGADALATVIVIEEVARVCASSSLIPAVNKLGTVPVLLSGSEELKKKYLAPVARGEAMFSYALSEPEAGSDAASMKTRAVRDGDHWVLNGVKMWITNAGVSEYYTVMAVTEPGAGARGISAFVVEKSDPGVSFGPKERKLGIKGSPTRQVILEDVRIPADRIIGAEGTGFKTALATLDHTRITIAAQALGIAQGALDHAVGYVKERRQFGKSIADFQGVQFMIADMAMKIEAARQLTYHAAIKSERAMNGEKVPDLTFVSSACKCLASDAAMEVTTDAVQLLGGYGYTRDFPVERMMRDAKITQIYEGTNQIQRMVMARQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E061</accession>
    <name>A0A1H6E061_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90851">
        <property type="protein sequence ID" value="SEG90851"/>
        <property type="gene ID" value="SAMN04489712_12757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="31502" checksum="EA584CFF77FCE958" modified="2017-01-18" version="1">MSTSGSRGMSNGARHGLGAVVGLVLTPVIGWLLMFGVDRLYRSMRVFRAEGADRWLGVAALVLAAVLLGLLVGSRLSPLASLIPGVVLTAVGLPWLFAAEWSFRTLRDLLPGRYYILYANLGSLGLWILVGCVLLAASFPPSRWRGAASAGPSRQSQYAPPPGGQWPPSSHQVPGQVPGQGPGDAPARQPSGVAGPPPFDPNARPYAPPPPWSAPGGEAVPGQPGQPGQPGPAVPQPPSPGSSAQHGSPPQGPGTPPQEFGGPPQAAGPSPQGQGPGRPQEGDGDEPGEWTRMYGGKDPRDDRPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0Y3</accession>
    <name>A0A1H6E0Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitroimidazol reductase NimA, pyridoxamine 5'-phosphate oxidase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91250">
        <property type="protein sequence ID" value="SEG91250"/>
        <property type="gene ID" value="SAMN04489712_12872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="15107" checksum="D10D405C68E74C99" modified="2017-01-18" version="1">MPYDSGGLEILDPEECRTLLAKVPLGRIVFTHRALPAVQPVNFILDGGDVVIRTGEGSKLAAAARNAIVAFEADDFDADARTGWSVVVIGPARVVSDPEETARLRDLPLRPWAPGRREAFIRIRPALISGRRTPETLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E362</accession>
    <name>A0A1H6E362_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92128">
        <property type="protein sequence ID" value="SEG92128"/>
        <property type="gene ID" value="SAMN04489712_13233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="125" mass="14131" checksum="CB0C206A4F9E5034" modified="2017-01-18" version="1">MDDGVYVGKAGPDAALDRGWLLGHFKDPSDLRHSDAVEIKWGVHPPGDERAEWTTGEERTALLVLISGRFRLEFPHRTVTLSEQGDYVVWGKGVDHSWYAEEESVVLTVRWPSIPGYRVGSEDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3P4</accession>
    <name>A0A1H6E3P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03084 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91515">
        <property type="protein sequence ID" value="SEG91515"/>
        <property type="gene ID" value="SAMN04489712_12944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="27234" checksum="712A660138F5A670" modified="2017-01-18" version="1">MLFGSLLDMEAAGIFEDLAAEHAQLRALLEGLEPAAWAAESDAKGWSVMDVVVHLAQSEELVAATVAGRKDAFARPDGVPLDAVMAAMVEEDRNTSHDQVFQRWRTAAADAVAALRGCPPDRRLAWAALPLSPRTLATTRIAEHWAHAQDIAVPLGLPYPDTARLRHIAWLAHRTLPYAFAVAGLDRPGPVYAELAGPGGELWTFGDPAAPSRITGPAAEFCRVGARRLAPEETTLLAQGPDAAAALRVVRNYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4G0</accession>
    <name>A0A1H6E4G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_13426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92532">
        <property type="protein sequence ID" value="SEG92532"/>
        <property type="gene ID" value="SAMN04489712_13426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="180"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG92532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="29514" checksum="946DDF5D0193BB4A" modified="2017-01-18" version="1">MPIVALLGTGIMGSAMARNLLKHGIRVRVWNRTQARAEPLRADGAQVAASPAEAVDGADVVITMLADGPAVLSAMRDAPDGLRAGQVWAQMSTVSLTDLESLAALAAEHGLTFVDAPVQGTRQPAEQGALLVLAAGPEAARPALEPVFEAVGQRTLWVGEHAGAAMRLKLAAVGYAISLTTVIAEALSLVEGLGVDPALFREVVSGGPLDSGYLQAKMRAILDGDYTTSFSVRNAGKDVQMITEAAAAAGLRLDVAAAAGERFRRAEAAGHGEQDMAATYFASFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4L4</accession>
    <name>A0A1H6E4L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92718">
        <property type="protein sequence ID" value="SEG92718"/>
        <property type="gene ID" value="SAMN04489712_13510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="71"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="30102" checksum="99EED55CFF8DC4FC" modified="2017-01-18" version="1">MTPSQAEQTPAAMIDRVSSLLGVFDGSRRLTLAQISRKAGLPRSSVHRILQRLVELGWVERHGFEYGLGLRIFEIGSLVVRQDGIRRVAVPFMQDLHLRTGLTVHLSVLRQTDILHIERIGGRPDDRDCWQVGARQPAQHTAAGRALLARLDPTELPDLDLSAPPTAYSVRSPAQLERELQKIRDYGVAVDVHGMVLGFASVATAIGPPGRSSAALSVTGPVSALKPDRLAAEIPATAASIWDAATAGRTRARSRSSVARAGAPRTGHQRTGDARHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5A8</accession>
    <name>A0A1H6E5A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent exoDNAse (Exonuclease V), alpha subunit, helicase superfamily I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92471">
        <property type="protein sequence ID" value="SEG92471"/>
        <property type="gene ID" value="SAMN04489712_1346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="977"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="878"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1135" mass="121817" checksum="53DD407704FDEAA6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5G1</accession>
    <name>A0A1H6E5G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92922">
        <property type="protein sequence ID" value="SEG92922"/>
        <property type="gene ID" value="SAMN04489712_13614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG92922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="24524" checksum="9F2B683C2BBB605B" modified="2017-01-18" version="1">MDPEPRSAKGRRTRARLVEAGKTVFERDGFLQARITDIATEANVSHGSFYHYFDSKESLFREIAEEVEVRLVSMDDIAQDLADDAGPIERIRAANKAYLTAYRKEARIMRVIEEVSRYNDDVRRVRSKRDDYLAARLESAIKRLQAEGLADKRVDERYAATALGGMVAKFAEMMFIGGARFDTNEAVEQLTLLWANALGLSPDADSKARARSEKAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6U6</accession>
    <name>A0A1H6E6U6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93450">
        <property type="protein sequence ID" value="SEG93450"/>
        <property type="gene ID" value="SAMN04489712_1391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="15371" checksum="4039A082F9DA2BF7" modified="2017-01-18" version="1" fragment="single">MTQIRGLGYLKVQTRHIERWRELAIDGLGFAEGSGPDPDGLYLRMDERRHRLAVLPGETDRVLAVGWEVRDQYALAAVREAVDKSGTQVTELSAAQAAERDAEQVIAFTDPAGTPVEVFFGPVLDHSPLRLGLDQKFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E853</accession>
    <name>A0A1H6E853_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR system Cascade subunit CasC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93902">
        <property type="protein sequence ID" value="SEG93902"/>
        <property type="gene ID" value="SAMN04489712_14127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010148">
        <property type="entry name" value="CRISPR-assoc_prot_CT1975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09344">
        <property type="entry name" value="Cas_CT1975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01869">
        <property type="entry name" value="casC_Cse4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="398" mass="43163" checksum="DBEABF5F1C33E8A8" modified="2017-01-18" version="1">MTTRTILELHALQTVPPSNLNRDDTGTPKTAVYGGVRRARVSSQSWKRATRRTFHDLLDPSELGVRTKRVAELLAGRIRGLDDSIEEAEAWALAAETIQAATGSKIEPPKRKASAKADGPDPAPESKYLMFLSARQLDGLAELAVKGRDDIKAFLKDKDNKAEAKQIANSRHSVDIALFGRMVADGADINVDAAAQVAHAISVHQVENESDYYTAVDDHKEREDDDLGAGMIGTVEFNSATLYRYAAVDVDLLSRNLGKGQREDEPLTEPVRRAVEAFVQGFITSLPTGKLNTFGNHTLPDAVVVKIRSTRPISFVGAFEEPCRADQAAGGHVREASERLARYVPEIERAYGADNAKTWVLRVGPNTTVLAELGDEVSLPDLVEAVGAEVAGRQSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8N5</accession>
    <name>A0A1H6E8N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93296">
        <property type="protein sequence ID" value="SEG93296"/>
        <property type="gene ID" value="SAMN04489712_13811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="154" mass="15751" checksum="6531BA96A20697D3" modified="2017-01-18" version="1">MSTPEERIAELGLELPDVVAPLASYVPAVRTGSLVYTSGQVPIVKGEVAVTGKVGAEVTVEEAVQAARICALNAVAALKAEVGELSRVVRIVKVVGFVASAPSFTDQPLVINGASDLLGEIFGDVGRHARSAVGVAALPRDVPVEVELIAEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8S8</accession>
    <name>A0A1H6E8S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000044">
        <property type="protein sequence ID" value="SEG94218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94218">
        <property type="protein sequence ID" value="SEG94218"/>
        <property type="gene ID" value="SAMN04489712_14413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="48035" checksum="3547376AEAC584F6" modified="2017-01-18" version="1">MNELKSPGKPFDISKPAVLEAWKKVKANKGVAGADGMSIEEFEKDLKNNLYKIWNRMSSGTYFPPPVQAVEIPKAHGEGMRMLGVPTVADRVAQTVVAGVLEAEIEPIFHPDSYGYRPGRSALDAVGACRQRCWKYDWVVEFDIRKFFDSVPWDLVVTAVLAHTDRPWVVLYVKRWLAAPLALPDGTLRERDRGTPQGSPISPVLANLFLHHAFDAWMARELPGVVFERYADDAVVHCSSLELAERVLAAIKGRMAGVGLQPHPDKTRIVYCKDDRRRGSHEHTSFTFLGFTFRPRGVRTKTGKMRCGFNPAVSKEALKQMSATVRAWRLHHRTGSSEHDLARRINPVVRGWMQYYGAFYRSALYPLLARINAYLMRWSRNKYKRLRGRKKAQDQWEKVVKARPRLFAHWIWVNTVPKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E953</accession>
    <name>A0A1H6E953_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93464">
        <property type="protein sequence ID" value="SEG93464"/>
        <property type="gene ID" value="SAMN04489712_1395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="196" mass="20738" checksum="D1661A7BAE807677" modified="2017-01-18" version="1">MNRDRRDRLRDAAITVLAEAGGRGLTHRAVDAAAEVPPGTAKNYFPTRDALLRAVAERCLEQYREIMAHLAAGPGPTGREGLVAMLRALIADVAGPGRPRLLAYLELQTEAARRPWLAALLDPIAAHDFAGFEAAQRAAGLPVTPQRAAVVTLAMHAAIPHLLAGGPGTLAAAGLDAPDRFVRALLQAVYPEPPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9F2</accession>
    <name>A0A1H6E9F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR02611 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94322">
        <property type="protein sequence ID" value="SEG94322"/>
        <property type="gene ID" value="SAMN04489712_14612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019099">
        <property type="entry name" value="Uncharacterised_PGPGW_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09656">
        <property type="entry name" value="PGPGW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="197" mass="21501" checksum="E84FD38E8D3D93C8" modified="2017-01-18" version="1">MSNLGGFQVGQGRSWPHEPGESAWGSNVAMNRDDRRRSAAELMDDVAEAVEDAAEEVGDAVEDAAEAVTGRFQRFREYIRRNKLLNTTWRIGVFTVGVTVLIGGLVMMIAPGPGILGIIVGLAILATEFAWAQRALHRARAAAEKAKEKAMDPKARRRNAILGVLGGILVGALVIAYLVVYEFTLPWNIADYTPWTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S8Q5</accession>
    <name>A0A1H5S8Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF46197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF46197">
        <property type="protein sequence ID" value="SEF46197"/>
        <property type="gene ID" value="SAMN04489712_10197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="13"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF46197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="15166" checksum="6C3C28ED82420A4A" modified="2017-01-18" version="1">MTNERVHRRAFKGEPAELARVRSFAAAALRGCSVLDDAVLLIDEVAANAIVHTDSETVEVALRHVGDVVRGEVRDAGSDSVPAPKADSEADGEGESGRGLLIVDLLAKQWGSRRTAAGRLVWFELHDPDCAPEPPEPESTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5STY8</accession>
    <name>A0A1H5STY8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4352 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53950">
        <property type="protein sequence ID" value="SEF53950"/>
        <property type="gene ID" value="SAMN04489712_101361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029051">
        <property type="entry name" value="DUF4352"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11611">
        <property type="entry name" value="DUF4352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4352" evidence="2">
        <location>
            <begin position="48"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF53950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="20303" checksum="4A02A675AEF8A260" modified="2017-01-18" version="1">MRRTLAAGALGLLALLPAACSDQDGPPSYDLGPRPVRESETPLPYRQTRLGEMRYTVLAIRTGLKEVVGSHGSWTPKGQYVRVRLLIENHGRDRHEFVPSAQMLVTADGRAHKPNHDAMSISRAVSGTQIVAREERRELDLWFDIPKTAPVRALRVNGDVSSSALGDQLKGVPAGTPDTVDIPLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SYS2</accession>
    <name>A0A1H5SYS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55645">
        <property type="protein sequence ID" value="SEF55645"/>
        <property type="gene ID" value="SAMN04489712_101414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF55645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="27780" checksum="97A8C3B6212232F7" modified="2017-01-18" version="1">MNDTEETVLVRHERSVAVITLNRPQALNAMTGPMSVAYARALREADADPQVRAIVVTGAGRGFCAGADLGVLNQGPDAIRALVPPAEDLPTMALRLRTPVIAAVNGPVAGIGFAYMMGSDVRFAGRGVKMTTSFSRLGLVAEYGLSWLLPRLIGASRAMELLLSGRTLDAEEAERIGLVHRVVEPDRVLQEAVDYAADLAAGCAPSSLAAIKAQVYADLERSHDDALADTLKLMDASFGGPDLAEALAARKEKRPPVFTPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SZL1</accession>
    <name>A0A1H5SZL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha,alpha-trehalose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55358">
        <property type="protein sequence ID" value="SEF55358"/>
        <property type="gene ID" value="SAMN04489712_101405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="7">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="5">
        <location>
            <begin position="333"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="6">
        <location>
            <begin position="706"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="367"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="598"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="760"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF55358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="819" mass="91141" checksum="99E761F63E04801D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T1P5</accession>
    <name>A0A1H5T1P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56696">
        <property type="protein sequence ID" value="SEF56696"/>
        <property type="gene ID" value="SAMN04489712_101447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF56696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="297" mass="30764" checksum="1C4739C9E5AEE5C4" modified="2017-01-18" version="1">MSGHVTDFAGRVVVITGGASGIGRALGEAFVRAGSHVVLADVEKARLEETVHDLGGTVTGVVTDVTDPDSVEHLAEEVYRRHGAVHVLVNNAGVGAPSADVWDTTPNDWRWVHSVNVFGVAHGVQAFLPRMLAGGQPGHVVNTSSGDGAVNPLPGASVYAASKAAVSTLTECLAVQLAGRGAPIGVSLFLPAGGLLDTGLWTAERNRPAGLARERPRSTPSITVAQLVEAAAAAGRELPVQPLDELAATVLDGIREGAYCISVEREDAARTLHERADRFGRGEVPTIPSGHGILDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TEH3</accession>
    <name>A0A1H5TEH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small multidrug resistance pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60608">
        <property type="protein sequence ID" value="SEF60608"/>
        <property type="gene ID" value="SAMN04489712_101569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF60608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="109" mass="10946" checksum="F8C01F010787074C" modified="2017-01-18" version="1">MPYVLLGLAIVAEVTATLSLRASEGFTKWGPSAIVVVGYLVSFMLMAKALTSLNVGPVYAIWSALGTIGAFAGGVLLFGEPVRPVAVAGAAIIVAGVVVMNLGGGMTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5THV1</accession>
    <name>A0A1H5THV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_101628</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62442">
        <property type="protein sequence ID" value="SEF62442"/>
        <property type="gene ID" value="SAMN04489712_101628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF62442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="553" mass="63281" checksum="2B94269B32B66B6E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TS33</accession>
    <name>A0A1H5TS33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64817">
        <property type="protein sequence ID" value="SEF64817"/>
        <property type="gene ID" value="SAMN04489712_101703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF64817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="6684" checksum="DD65541C95C0A224" modified="2017-01-18" version="1">MKIVIDRPRCEGHGLCEEAAPQLMHLDDDGELVLDREEISDADASLANAAVRVCPVAALRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U5H5</accession>
    <name>A0A1H5U5H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69541">
        <property type="protein sequence ID" value="SEF69541"/>
        <property type="gene ID" value="SAMN04489712_101856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF69541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="30662" checksum="9EA99AC9FAB19E62" modified="2017-01-18" version="1">MSAATFRTPSGPDSIEIIDVPVVEPGPGEVRVEIAAAAVNPVDLAVARGLFHSMGLVDQPERTGLGWDFAGTVVATGTGVDLAVGTRVAGLVDGFDRDFGTYAEQLIVRACDIAVVPDGLDLVAAATVPLNGLAAAQIVDLLGDASSDGDRLLVTGAAGAVGGYVASLAQDRGWQVTGLARAEDEEFVRGLGAEFTTHAQPGWDAVADGAALQEQALALVRDGGTFVGVQPSAKPAAERGITVDVVVTHPDGARLGDLLARTVSGELPARVHAVVPLDQVAKVHRAMAKGGVRGRYVLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UWA8</accession>
    <name>A0A1H5UWA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Electron transfer flavoprotein alpha subunit apoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79452">
        <property type="protein sequence ID" value="SEF79452"/>
        <property type="gene ID" value="SAMN04489712_10265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="7">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF79452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="316" mass="32582" checksum="4709F71E2AD1EB41" modified="2017-01-18" version="1">MAEVLVLVDHVDGEVKKVTLELLTAARRLGEPAAVWVGPGVEGAKDKLAEYGAAKVYVAADEELTSYVVAPKVELLAQLVADKSAAGVLVAATGEGKEIAGRLAVRLDSGVLTDVVDLADGFVGEHSIFGGAVIAHAKVKRGTPIVAVRPNSVAPEAAPAAAAEEQVSVTLSDAAKAARVVEKVVQEKGERPDLTEAAVVVSGGRGVGGADNFKVIEDLADSLGAAVGASRAATDAGWYPHQFQVGQTGKTVSPQLYIAVGISGAIQHRAGMQTSKTIVAINKDPEAPIFELVDFGVVGDLFQVAPQLTEEITKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UZK3</accession>
    <name>A0A1H5UZK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized domain 1-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80380">
        <property type="protein sequence ID" value="SEF80380"/>
        <property type="gene ID" value="SAMN04489712_10298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="86"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF80380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="178" mass="19079" checksum="915B8BFD933C52BD" modified="2017-01-18" version="1">MAGHGDRSGAWGSFPTTTERECLVSVESELDLWNTLSGAELIKAMGEGRFPQFTPINEHIGQVVSEVEHGRVRLAWSPEDKLCNPGGIVHGGYIAMILDNAVCLAASSTGEHFMPMLTLSLNVDYVRPVQAGRPYDVEGVCVHPGRTRMLSTATITDAGGRLIAQATASVTPNQAFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V2Y1</accession>
    <name>A0A1H5V2Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80777">
        <property type="protein sequence ID" value="SEF80777"/>
        <property type="gene ID" value="SAMN04489712_102112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009286812" evidence="3">
        <location>
            <begin position="29"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="67"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF80777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="27505" checksum="F859B29FADB4F214" modified="2017-01-18" version="1">MSQVPAARRTLAVLRLLASSAGPMPAPAIARELGLPRSSAYHLLREMAADGFVVYLPEERLWGLGVAAFEIGSAYLRQGPLERLGRPPLRRLVDRTGEIAQLGVLHGAETLYLLKEQPPRHDTLVTDVGVRMPAPLTASGRSILAYLPAAQVRALFPGPLVNRTGRGPASLRELRRVLGEDARRGWSVEDGLVTEGFASIAACVFDHVGHPTAAVTVTFRRAGRPEDTWPDLAALVRATAAEITRRLGGRDPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V8P2</accession>
    <name>A0A1H5V8P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83131">
        <property type="protein sequence ID" value="SEF83131"/>
        <property type="gene ID" value="SAMN04489712_102196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF83131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="28254" checksum="267BC9B9CC30EC9C" modified="2017-01-18" version="1">MSIERVPLRGLGPSVGAPRIPKYYKLKELLVELTQSLPAGSPLPPERTLAERYETSRTTVRQALAELVVEGRLQRIQGKGTFVAKPKVAQELQLTSYTEDMKHHGLHPETKILDIGYASADERLARLLGIRPGGRVLRIHRLRLADGEPMSIDTSHLPARRFPGLRRELPRHRSLYETLGTAYDVHLAEAEETIETVLATPHDAQLLGVDVGLPMLLLSRHAFDTAGHPVEWAQSLYRGDRYKFLTRLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VB86</accession>
    <name>A0A1H5VB86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83707">
        <property type="protein sequence ID" value="SEF83707"/>
        <property type="gene ID" value="SAMN04489712_102216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF83707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="31011" checksum="49086DE4B0F41C55" modified="2017-01-18" version="1">MPHDLPAWVAELTDPRRARTLDELADRLVPLAEHAIDVSRRLQGLLNELNEPFQREALHERVERLKARTGEAFGEVSEEIAASGRERVARIHAACEERAAGPVAQQAARRAAELRDRLEEEVGPLIVRQQRAAAGQVRQRAGTALDEAVRQLLGRVEELAEAVTDLIHEVLPLAREGLELAGRISGLSGRARSAGHGPIPAELAAEAAETAAAFDEAVGRLELEWSALGARGATVRAALRAAEETAFSQITAEMTRCVAELAPGHARALGEAEARAMTLLGELTGGSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VLK0</accession>
    <name>A0A1H5VLK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative copper resistance protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_102368</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88134">
        <property type="protein sequence ID" value="SEF88134"/>
        <property type="gene ID" value="SAMN04489712_102368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="9">
        <location>
            <begin position="317"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF88134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="725" mass="73622" checksum="A4DB94709C20BD34" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VQF1</accession>
    <name>A0A1H5VQF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">SAMN04489712_102405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89168">
        <property type="protein sequence ID" value="SEF89168"/>
        <property type="gene ID" value="SAMN04489712_102405"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="9"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF89168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="45204" checksum="A0C7271FAA9C1D46" modified="2017-01-18" version="1">MSFGLYDPLSAVDPEVAEAVRSELRRQQSTLEMIASENFAPVSVLEAQGSVLTNKYAEGYPGRRYYGGCEYVDVAEQLAIDRARELFGAEHANVQPHSGAQANTAVYFALLEHGDTVLGLDLAHGGHLTHGMRINYSGKTLNFVPYHVRATDGRVDMDEVAALAVEHRPKMIVAGWSAYPRQLDFAEFRRIADSVDALLMVDMAHFAGLVAAGLHPSPVPHADIVTTTTHKTLGGPRGGMILCRQEYAKKINSAVFPGMQGGPLEHVIAAKAVALKIAASEEFRERQARTVEGARLLAERLTGEDCAKAGVRVLTGGTDVHLVLVDLVDSELTGRDAEDLLHSIGITVNRNAVPNDPRPPMVTSGLRVGTPALATRGFTAEDFAEVADVIALALQPEPDTTALAARVRALADRHPLYPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VXT4</accession>
    <name>A0A1H5VXT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92099">
        <property type="protein sequence ID" value="SEF92099"/>
        <property type="gene ID" value="SAMN04489712_102511"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
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        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="38"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="253"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF92099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="443" mass="47316" checksum="73B967CCD7A6E3AF" modified="2017-01-18" version="1">MSELTGVAAPGGARRIVMASWRPSAMVRSSLTWRAAVYLATSLGFGLAWFVFLVVGLALSAGLLVIWVGVPLLAAVMLIWRGGAMLERRLLRAGFGVTVPDPYRPMPPSSGLLRRWRAMATDPATWKDLAYLGLRFPIGIAEFVVSVAVWGMAGSFLFLPAIVVVKDRAVINFGDWLFYTADDPLTALPMSAVGVVLLLVAMYVTRGMAVLHALYGVFLLGAGRDQAERVRLQARAEHLQASRARGVDAAEAERRRIERDLHDGAQQRLLAVAMDIGRARAKLDDDPEGARALIEQAHAGTKEAIAELRDLARGIYPAILTDRGLDPAISGLAARAPVPVLVEVDLPERPPAAVESIAYFIVAESLANIAKYARATRASVRITRETHWVVVEVTDNGVGGATSTPGGGLAGLADRAATIDGILTVDSPPGGPTVIRADLPCTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VYT7</accession>
    <name>A0A1H5VYT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92293">
        <property type="protein sequence ID" value="SEF92293"/>
        <property type="gene ID" value="SAMN04489712_102518"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF92293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="16530" checksum="664F77D87D18F9D5" modified="2017-01-18" version="1">MRPDGEWTSLAAVSEVEGRAGGRPLGRVLVVDDDEVIRQLIAVNLQLEGFEVATAVDGQDCLDKVAEVAPDVITLDVMMPRLDGWVTAVRLREDVATRGIRVVMITARAQDHDIRRGHDIGVDAYITKPFDPDELIRTVRELVESGRLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W0R6</accession>
    <name>A0A1H5W0R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arc-like DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93070">
        <property type="protein sequence ID" value="SEF93070"/>
        <property type="gene ID" value="SAMN04489712_102546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005569">
        <property type="entry name" value="Arc_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03869">
        <property type="entry name" value="Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arc" evidence="2">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF93070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="7140" checksum="1BD04CD966D4F09E" modified="2017-01-18" version="1">MIRLSLRLPDDLHTRLVARAHADRRSLNSEILHLLETALNTTDDESPGGDTSSPAPPRGKPDSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W0S1</accession>
    <name>A0A1H5W0S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_102547</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93095">
        <property type="protein sequence ID" value="SEF93095"/>
        <property type="gene ID" value="SAMN04489712_102547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="11">
        <location>
            <begin position="721"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="352"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="527"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="731"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="795"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="896"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF93095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1046" mass="111070" checksum="EF6FE95A44AC3A8C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W214</accession>
    <name>A0A1H5W214_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_102555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93328">
        <property type="protein sequence ID" value="SEF93328"/>
        <property type="gene ID" value="SAMN04489712_102555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF93328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="551" mass="59133" checksum="35F3D502A06ECF13" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W3D8</accession>
    <name>A0A1H5W3D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94064">
        <property type="protein sequence ID" value="SEF94064"/>
        <property type="gene ID" value="SAMN04489712_102576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF94064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="28635" checksum="E3B12517AB9C8C52" modified="2017-01-18" version="1">MQRLPISTAHCTVEQDGPVVIVTMDRPEARNALSSSMLVGMASAFAYISATPEVRVGILTGAGGQFCAGADLKAMGAPPEDEDTRRRMAEIPNFHWKGLLREDVPTKPIICAIEGYAVAGGTELLTGTDLRVVAESATLGLFEAKRGLFPMGGSAIRLPRQIGYAAAMDILLTARSVTPQEALAMGLINKIVPDGQALAAARELADQIAACGPLAVQAILRVYRETAHLPEEEALKVSDEIGWPVLGSEDAKEGTRAFREKRPAVFRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WE84</accession>
    <name>A0A1H5WE84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97107">
        <property type="protein sequence ID" value="SEF97107"/>
        <property type="gene ID" value="SAMN04489712_102665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021888">
        <property type="entry name" value="DUF3499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12005">
        <property type="entry name" value="DUF3499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF97107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13683" checksum="B8034A766E30EF1D" modified="2017-01-18" version="1">MSPARICSRTACKEPAVFTLTYVYRDSTAVLGPLATYAEPHCYDLCAEHSERLTAPMGWELVRLPVEDGRPSVDDLEALADAVREAAKPPAAGQEPVGQGVEVGRRGHLRVLRSGTNPPPASAEQGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X605</accession>
    <name>A0A1H5X605_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methylated-DNA-[protein]-cysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_103104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07194">
        <property type="protein sequence ID" value="SEG07194"/>
        <property type="gene ID" value="SAMN04489712_103104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006304">
        <property type="term" value="P:DNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="7">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG07194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="180" mass="18877" checksum="E948E761ABC255C3" modified="2017-01-18" version="1">MDGTVAFGAVDTPLGRMLVAVTGSGVMSVDFHDSPAARARVAERSGLTPVDDPGRAGAATEGLAAYFAGRSREFGLPVDWRLTSRVQRRVLQTLYETVPYGKVLTYGELGDRSGIGVPARAIGQVMGANPIPVIVPCHRVVAGNGLGGYSGGSGVEIKRWLLTLEGALPATFDWDPERGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X8U5</accession>
    <name>A0A1H5X8U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08178">
        <property type="protein sequence ID" value="SEG08178"/>
        <property type="gene ID" value="SAMN04489712_103144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG08178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="88" mass="9570" checksum="71C44025A4E9769B" modified="2017-01-18" version="1">MIERAEREEDLGHEPEVTHDRDFAPVNRGADARGGTVTPQEEGMARQEDEPGTGTPGVDVGHPDAIPPDAEGVAEAERQDSSRYYKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XEA9</accession>
    <name>A0A1H5XEA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="3 6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">idi</name>
        <name evidence="10" type="ORF">SAMN04489712_103215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3 6"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10049">
        <property type="protein sequence ID" value="SEG10049"/>
        <property type="gene ID" value="SAMN04489712_103215"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR018427-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG10049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="21038" checksum="F874BCEFE58780CE" modified="2017-01-18" version="1">MATEEIVLLNAAGEAIGTAPKAASHHQDTPYHLAFSCYVTDDEGRVLITRRALDKATFPGVWTNTCCGHPAPGEGLREAVVRRLDTELGLPVDGLTLVLPEFDYRAIASDGVVEHERCPVVRARWTGGGRPRPNPAEVADARWRTWEECLELTADPDASPWFRLQMAQLAPLGPPEKWPGADPSRLPPALTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XG33</accession>
    <name>A0A1H5XG33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphopantetheine attachment site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10702">
        <property type="protein sequence ID" value="SEG10702"/>
        <property type="gene ID" value="SAMN04489712_103238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="527" mass="57189" checksum="43930A5B49AD1A9D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XRF0</accession>
    <name>A0A1H5XRF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14389">
        <property type="protein sequence ID" value="SEG14389"/>
        <property type="gene ID" value="SAMN04489712_103378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG14389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="125" mass="13214" checksum="CCCADA2A6CBBE0A6" modified="2017-01-18" version="1">MVANPSPNEASIARVRAVVYARGADAREEDHAVAQCERWAARHDWEVGAVVRETSDIEPPLERWGVRVALGLLNSGRASVLLALSRITISDENAAFHAVCAAAESAGGFVHVLDSAESGAADARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XV05</accession>
    <name>A0A1H5XV05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar or nucleoside kinase, ribokinase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15096">
        <property type="protein sequence ID" value="SEG15096"/>
        <property type="gene ID" value="SAMN04489712_103405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG15096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="31941" checksum="93F3A7AF9653D791" modified="2017-01-18" version="1">MTRVVVVGDLMTDTVARAAYPLAKGSDTPAMVTMHGGGSAANVASWLAVEGGEVTFVGRRGADIAGRNRDMELMGLGVDARTVMDNERPTGSCVVMVTHKGDRTMLSDPGANAALLPEDIPAELFGQGAHLHLSGYSLLNEGSRKAAQHTLALARKAQMSISVDAGSSSPLKRVGAEPFLEWTQGARLLVVNAAEAEVLTGREEPQAAAKVLTAWYPQVVIKMGADGALWYTNGRPEPIVAPAQPIDKIVDGTGAGDAFIAGFLPPWLDGKPPAEALAAGCALAARAMTRIGARPTLDVVDNEIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YJ14</accession>
    <name>A0A1H5YJ14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23984">
        <property type="protein sequence ID" value="SEG23984"/>
        <property type="gene ID" value="SAMN04489712_10438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG23984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="170" mass="18877" checksum="29DBD3AED1BB395A" modified="2017-01-18" version="1">MDANTVTAVCAVVIALGSLAVSVTETRMTRQHNRHSVRPILQLRRTKLLNDVPAGLRVVNCGLGPAIITKTLVRLDGNPVGGWNLPTYRQVTDGFPIQPRVTTLTDGAALPVGHEAFLLRLDDFEDERHSWFWELITVRLQVEIHYQSLYGGKTFVATTTPWPGNRPTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YUY8</accession>
    <name>A0A1H5YUY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27255">
        <property type="protein sequence ID" value="SEG27255"/>
        <property type="gene ID" value="SAMN04489712_104169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="411" mass="42348" checksum="87107DF4CBC0B2AB" modified="2017-01-18" version="1">MLAALAVVAALGLLGGRRGRDAGTGRAMSRTDRPRHGEVGAADLMDDRREQRHEESPRPGGPAPEAAGSGRSRSDRPLLRVGSLGPVATAVAFAVLVAGAVDFVNDRQSGGSDGKKPAEKVAKTVGNDKEAAPPRHVVAIRRAGEAVSIRDARTGANVGVDAAAPQGQRWHQVASAGNGSYVLSAYSPGRITFYRLTLSEDGAPRKLAQIPGLAVRGASSAARSDMAVSEDGKRIAYVAYGAGGVGRIEIASAKAADRRQWAASSPGRVSSLSWAGDTLSFVWTTVRGTAVRRQVRTLDTTAAGADLRVSKPVLMLPEGGTAAVLNGDGTTIVAGVRAASGLSLQEFSAATGRRTKVLWTREAGRSGELSGLTRHSEGGHVLAAGTEELVYAVPGKGVRGVPAEGYADVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YWD6</accession>
    <name>A0A1H5YWD6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6292 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27516">
        <property type="protein sequence ID" value="SEG27516"/>
        <property type="gene ID" value="SAMN04489712_104182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046259">
        <property type="entry name" value="DUF6292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19809">
        <property type="entry name" value="DUF6292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6292" evidence="1">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="15290" checksum="C72450D4B28DC80F" modified="2017-01-18" version="1">MRDRTELKTHPVAWVNLTEHYIASLMDALAGHGVRISAAWLDPIDPRDATIVLQRPGGQTEAVVWDEETGLRAGRFVTGRQGERTELAGAAYLGGGLLPEPQDAARRFLLGAREPRVVHRLHTDVRDGFDDHLRDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZHG5</accession>
    <name>A0A1H5ZHG5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="8">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_104530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 11">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35077">
        <property type="protein sequence ID" value="SEG35077"/>
        <property type="gene ID" value="SAMN04489712_104530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="PTHR11822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="13">
        <location>
            <begin position="9"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="94"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="310"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG35077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="407" mass="45529" checksum="FA0366D370462BBF" modified="2017-01-18" version="1">MPKIKVAGPVVELDGDEMTRIIWHFIKDQLILPYLDVDLKYYDLGIEHRDATDDQVTVDAANAIRKYGVGVKCATITPDEARVEEFGLKQMWRSPNGTIRNILGGVVFREPIIVSNIPRLVPSWTKPIVIGRHAHGDQYKATDFKVPGPGTLTVTFTPEDGSEPIEFQVAQYPEGGGVAMAMYNYRKSIEDFARASFRYGLDREFPVYMSTKNTILKAYDGMFKDVFAEIFEAEFKADFEAKGLTYEHRLIDDMVAAAMKWEGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGRTVEAEAAHGTVTRHYRQHQQGKPTSTNPIASIFAWTRGLAHRGKLDNTPEVTAFAETLEQVCIETVESGQMTKDLALLVPGEQEWLTTQEFLHALDVNLQKKVSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZUV9</accession>
    <name>A0A1H5ZUV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40313">
        <property type="protein sequence ID" value="SEG40313"/>
        <property type="gene ID" value="SAMN04489712_10527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG40313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1290" mass="143783" checksum="20606E69A5A0A4FA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A187</accession>
    <name>A0A1H6A187_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="6" type="ORF">SAMN04489712_105141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42488">
        <property type="protein sequence ID" value="SEG42488"/>
        <property type="gene ID" value="SAMN04489712_105141"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="234"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="375"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG42488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="536" mass="57501" checksum="44D73A99B1C236C8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A294</accession>
    <name>A0A1H6A294_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4178 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42571">
        <property type="protein sequence ID" value="SEG42571"/>
        <property type="gene ID" value="SAMN04489712_105146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025235">
        <property type="entry name" value="DUF4178"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13785">
        <property type="entry name" value="DUF4178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4178" evidence="2">
        <location>
            <begin position="58"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG42571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="22084" checksum="707C7DBBD88E8D89" modified="2017-01-18" version="1">MLAVVITLLVLILVALVVLIAVLLRRRGTGGGTEQAPAAPADPFASVGEVAGDPRTLKAGDMVEYLGTRYFVRGSVRLREGGYTWSEHLLDADTIEGTKVWVSVEEDPDLEVVWWTERDVGDLRPDRSTLTLDGVEYRREEHGTAEYRTEGTTGLGDTGRVEYVDYEGPGGRYLSFEKFGGGSWEAGTGERVPTGTLTIYPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A6V3</accession>
    <name>A0A1H6A6V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44469">
        <property type="protein sequence ID" value="SEG44469"/>
        <property type="gene ID" value="SAMN04489712_105253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="28815" checksum="95AE0630D3FFCC60" modified="2017-01-18" version="1">MADQTIRPLPDRVRRAISDPGAILPRAVEVRDGEEIRETVPSWSTRAVLAVLADAGSPLAPERAAEIEALTAAATPGPWSVDTVGGLFVEAAEGAVADLAWAAQDETELAAIKADAEFIAAARADVPLLLAAYREVDAHRCVQASRIADLEAERDRARNVALAAERTLGEQIDRALRCEAERNALRAQADRYVQRIQELAAAHRGKQAAAAEWKRLHGNLKTDRDRLAAQRQAALDVAAQHHDIAPEGEECAVGCPGCQVEAALGVAKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADL7</accession>
    <name>A0A1H6ADL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol S-conjugate amidase</fullName>
            <ecNumber evidence="2">3.5.1.115</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mca</name>
        <name evidence="3" type="ORF">SAMN04489712_105327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate</text>
            <dbReference type="Rhea" id="RHEA:36543"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58718"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:59633"/>
            <dbReference type="EC" id="3.5.1.115"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MshB deacetylase family. Mca subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.115" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45846">
        <property type="protein sequence ID" value="SEG45846"/>
        <property type="gene ID" value="SAMN04489712_105327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010127">
        <property type="term" value="P:mycothiol-dependent detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01482">
        <property type="entry name" value="Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03446">
        <property type="entry name" value="mycothiol_Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG45846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="33581" checksum="AD2A81D4A0097684" modified="2017-01-18" version="1">MVSEVPTGTTSCDDGPLRLMAVHAHPDDESSKGAATMARYVADGAEVMVVTCTGGERGDILNPAMDKPEIKANIGAVREQEMARAREILGVRQEWLGFVDSGFPEGDPPPPLPEGCFALQPLEVAAEPLVRAVRAFRPHVILTYDEKGGYPHPDHVKCHEVSVEAFEAAGDPDRYPGTGEPWQPLKLYYHMTFHKDRLVALHAAMEEAGLESPYGDWLKRFDDGPAPWAVTTRVPCADHFETRDKALLAHATQIDPNGFWFMCPLDLQRRAWPTEDYHLARSLVDTELPEDDLFAGVREKVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AI97</accession>
    <name>A0A1H6AI97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48112">
        <property type="protein sequence ID" value="SEG48112"/>
        <property type="gene ID" value="SAMN04489712_105457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046203">
        <property type="entry name" value="DUF6236"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19749">
        <property type="entry name" value="DUF6236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG48112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="444" mass="48694" checksum="F2764AFCA918DD29" modified="2017-01-18" version="1">MAVPNEPPTNQDHTLAHNKGGLGFGRHALYYPYFHVRDERWLKLAALYWPKLVRIVPDGYRTRDSDTVLALGDEFIVRLPPGRSVDAVAPLFVRLSADHADRVRPVLGVLNEQTELARWFQRRRTRNLHPLARRAEHPLTGVHVTQVAPAVLEALQEAGLAVAPDTGLWHSALHQQNRGWPESALDGRPHADYAEWVVMRAELAAVYTTVLAQDFAAANSLQPTTDQEDAYTVATDWTTDGIAAALLHQPRPPSPSQGELAQRLGFLALDVVVPAHLDTIPVQKILEVRRRYGAEFFAFGRAVDEAATALAQDLPHITDQVVLENYLRDIVATQFDQPREELRRALRRAMGDAALASINVKVDLPAGAAIAGGAWLTGHPLLAGTLGAAIGLMTIGRGARQQRDAARQSSLAVSYLLHTESSLQAHGLLARTLARLTHMTGDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AIE6</accession>
    <name>A0A1H6AIE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_105448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47934">
        <property type="protein sequence ID" value="SEG47934"/>
        <property type="gene ID" value="SAMN04489712_105448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG47934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="439" mass="45761" checksum="1AD65DA4D3E12DCB" modified="2017-01-18" version="1">MLSTLALARSFDRPVRLLLINQLTINTGFYMLMPYLAGHLSGNLGLSAALVGLVLGVRNLSQQGMFLIGGSLADRLGCKPMIVAGCALRTVAFLLLGVAGSVPVLIVASALTGLAGALFNPAVRAYLTHRAGDRKVEAFAAFNAFYQLGILIGPLIGLVLNGVAFRLVCLTAGLMFAVLTVAQIRALPAQAGGAAGTRRTMLADWREALANRAFLMFSAAMAGSYILNFQVYLGLPLEVRRTTASQAGVTAIFVISGVLTIAGQARVTGWAQRHWRPARAITWGLVLMAGAFVPVALAAPFLRTAATSPGWPAHLLALLPIMAAAALLTLATMIVYPFEMATITTLGGERMVGTYYGLYSTLSGVGIAAGNLLSGAALDAGRAIGMPGLPWLALTLTGVISALALYVLDRTNRLTPVPDLTTHPPENTAQPARPATGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AIP9</accession>
    <name>A0A1H6AIP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48623">
        <property type="protein sequence ID" value="SEG48623"/>
        <property type="gene ID" value="SAMN04489712_105485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG48623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="358" mass="37998" checksum="18778CDC2D151C99" modified="2017-01-18" version="1">MTIQEETNDPRLTVVGASNAPTGSAFGRAVADGTVFQIGGGLVTGFGVEAAKSVIVGDPAGRWWFVLLCVLGIALVGVGLWLRARAAAKVQVGIVVTAADTGRGAARAARLEEQAETYSRDTCAVTLKTGLRLPETRPWPREGIDALADETLTAVTMAERLTAGATRINLIPTMPLHTGFRFGARIGHTHAREIAVHAIRQADGAPAYFPATTLRAMATTMEPLTVEPLETIDGGDPLRVALALDLQGRGEDFRQPVRAACRQHGIGTLLLLRNTTDTLEENAKTFGAVVEQTCRAWREAPLPTAARNGHHAVFLSGPVAISIALGARLAAAHPDRWTAYTFDNTTNTYEPFPAPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AKX4</accession>
    <name>A0A1H6AKX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48880">
        <property type="protein sequence ID" value="SEG48880"/>
        <property type="gene ID" value="SAMN04489712_105502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG48880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="29590" checksum="239B3D46DB2CFD86" modified="2017-01-18" version="1">MEPITARDGASIALHSTGSGPGIVVVHGGGVTIGVYRRLAAALADRFTVHLYNRRGRADAPPRSEPYTFEQDIDDLAVVLEHTGARNVIGHSSGGFIALQAALRLPMDRLALYDAAISIDGVFPAAWLEAAREALRAGDTARGLAITSAGINTQSAAAKLPLRVRTAICGLFLRTPIGRTMGDLLPMTLDETELIRAHDGPADQWAGVTAEVLLACGADGPPYYVEVNEALAHALPRVRTLQIPRSGHDAINRARPRLVNPLAEFFTTPATRERAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ANE9</accession>
    <name>A0A1H6ANE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49720">
        <property type="protein sequence ID" value="SEG49720"/>
        <property type="gene ID" value="SAMN04489712_105546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="2">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG49720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="72" mass="8297" checksum="B6C7341B09652B79" modified="2017-01-18" version="1" fragment="single">MIREIHAESRGSHGSPRVHAEPALGLGEQVNRKRVERLMRRAGLQGVYRRRGRRDLVNAATEEDLVQRHFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6X5</accession>
    <name>A0A1H6B6X5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">SAMN04489712_106323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56591">
        <property type="protein sequence ID" value="SEG56591"/>
        <property type="gene ID" value="SAMN04489712_106323"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="248"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="296"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG56591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="38473" checksum="91134AF435BB2C3A" modified="2017-01-18" version="1">MRVLTVNPGSSSLKLSLLEDDDTTVSRADLATGPAEREGEVLAAALSRMPVPDAVGLRFVHGGSDYHGPVLIDDAVTKRLYELVDLAPLHQPLSLYGLEEIRRALPDVPAVACFDTAFHAELPDAAATFPLPAEWRERFKLRRYGFHGLSHAYATRRTGQMLEVDPARLRIVVCHLGAGASLAAVAGGRSVDTTMGFTPIDGLVMATRPGSVDPGLLMWLLQHDVAIEELSEALIHRSGLKALAGTGDMREIERRAAGGDMAAQLAVEVYLHRLRGCIAAMTAALGGLDVLVFTGGVGEHDARVRRSVAEGLAYLGVDVDEEANESAHADADITAAGAAVRTLVVTSREDLEIAAGVRRVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BG49</accession>
    <name>A0A1H6BG49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59305">
        <property type="protein sequence ID" value="SEG59305"/>
        <property type="gene ID" value="SAMN04489712_10760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG59305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="26875" checksum="97A89AA4FF5F5017" modified="2017-01-18" version="1">MGYADELFDLTGRVVLVTGGSRGLGREMALAAARCGADVVIASRKYDACAATAEEIERATGRAALPYGVHIGRWDQLPGLVDAVYERFGRLDALINNAGMSPVYDSLDSVTEKMFDAVLNLNLKGPFRLSVLAGERMKAAGRGAIVNVSSTGSIRPRAAIVPYAAAKAGLNALTEGLAQGLGPQVRVNTLMAGPFATQATRHWEDDKNKLDEGVRPHALQRIGKPSEVVGAALYLISDASSYTSSATLRVDGGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJZ1</accession>
    <name>A0A1H6BJZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">SAMN04489712_107149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60687">
        <property type="protein sequence ID" value="SEG60687"/>
        <property type="gene ID" value="SAMN04489712_107149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="129"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="142"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="199"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="129"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG60687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="377" mass="40842" checksum="F93246B842497C27" modified="2017-01-18" version="1">MARDYYAILGVRRDASPDEIKKAYRRLARELHPDVNPDPETQERFKEITQAYEVLSDPKKREMFDLGADPFAPSGAGAGAGFGAAGFPFSDIMDAFFGTAASRGPRSRARRGRNATLRVELDLAETAFGTTRELAIDTAVVCTACSGAGTAPGTHPETCDTCHGRGEVQQVTRSFLGQVMTARPCPQCGGYGSVIRHPCPECSGDGRVRTRRTIKVRIPAGVESGTHIQLAGEGEVGPGGGPAGDLFLEIVERPHPIFEREGDDLHCTVQIPMTAAALGTQVVIETLDGPEEVDIRPGTQSGQVIPLYGRGVRHLNESGRGDLMIHVNVETPTKLDEEQEELLRRLSKLRGEERPPGKFAPGQQGFFSRLRDVFNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BN90</accession>
    <name>A0A1H6BN90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62102">
        <property type="protein sequence ID" value="SEG62102"/>
        <property type="gene ID" value="SAMN04489712_107273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG62102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="39308" checksum="AAA295AEEBE7D7E0" modified="2017-01-18" version="1">MASGAGSNTIPGTGTFFVGIDIVPGRYRCDDGKGGWWVRFTGPDGDDPVGSWPLPAGPTEVEIEPTDFAFETRVGTYWRLVAPGHVAGQRRSGPEPRPVADPTLRAELDGIVAARRPPPWLIPLLVVALFAGGAAVLGPLWLLYTAPAGITGAVGARMVDDLVRARALSRRRDRYLVPEDLDDDGRALLARAQQALTAVQESQVNREGMLDPVDNAVTLPRQEWEIAQALARQSRLRRRQHELAESAGSIPEVAAAMRPLHHKLELSVRAVTRRVEALERYAERARAADEALRAHRQLEKLAEGAHEYDELLAETVRDDLALPVIERLAEQGEVLVHVLRARLAEAAEAGGELPVSPPGKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C561</accession>
    <name>A0A1H6C561_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methanogenic corrinoid protein MtbC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67496">
        <property type="protein sequence ID" value="SEG67496"/>
        <property type="gene ID" value="SAMN04489712_108293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="108"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG67496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="375" mass="40492" checksum="1812EEBD331D5D12" modified="2017-01-18" version="1">MSDPLRQAEPPVAMSTWTDRLWDAVTAGEEYAAADTAIAALDDGMDIEDLLLEVIAPLQARVGREWAANRMTVAQEHTATAVNERLIAAVAHHPAVRERRDERAADRLGRITVACIDGEWHALPARIVAEVLRLRGWHVDYLGAQVPTPHLIGHLHRTGPSLVALSSSIATRLPAAHAAIIACQATGTPVLVGGAAYGPAGRYASLLGADGWAGDARIAADRLAEAPLPPPSPPRQAIDDLPHLADQEYTHITRTATQLVRHVLGRLPSHVPVMVDYTDRQRRHTAEDIAHIVDFLATALYLDDPDLFTGFLTWTAGILSARNVPAHSLLPALELLSEQLADYPRATDMLTRAHTAITRPSPRTIEAGMSGGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C6U6</accession>
    <name>A0A1H6C6U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68633">
        <property type="protein sequence ID" value="SEG68633"/>
        <property type="gene ID" value="SAMN04489712_1098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG68633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="131" mass="14500" checksum="3206FB853C66E8AB" modified="2017-01-18" version="1">MPGQIPDSLGEVGRGWHPLLLRLHEQLLAVNPGYRVNQVKEKYGTLRVYLVSGLLLEPYFGSGRLPDPQRSAEIERENAQARRLVAAAEEESARTCEACGNPGRTRDGHWLKTLCDDCHGPGPCAGRREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCG0</accession>
    <name>A0A1H6CCG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70325">
        <property type="protein sequence ID" value="SEG70325"/>
        <property type="gene ID" value="SAMN04489712_109161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="22235" checksum="D9D92B31501531ED" modified="2017-01-18" version="1">MLADFWFDPSCPYSWITAQWLREVVTVRPVELRWHLMSLSVLNEGREDDPEGDPEGYLWLPVRICAAVEQEYGQDALVRFYTALAARVHAPAPEWGPDLFHSALAEAGLPEKPAEAARSTAYDEVIRASHAEGVGLVGDHVGTPIVAVTAPDGGRIAFFGPVISRVPRGEQAGRLWDGTLLVAGTPGFHEIKGPPADPDPFRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDU0</accession>
    <name>A0A1H6CDU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_109248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71179">
        <property type="protein sequence ID" value="SEG71179"/>
        <property type="gene ID" value="SAMN04489712_109248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG71179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="28877" checksum="7083B286439EC32E" modified="2017-01-18" version="1">MSGEVLRLSDVGVRREQSMLLREVTWTVQENERWVVIGPNGAGKTTLLQLAAAMLFPTEGTVEVLGERLGRTDVFDLRPRIGFASSAVAEKVPADEKVIDVVLTASYAILGRWNEEYESADVTRAVELLDALGCAELIRRRFATLSEGERKRVQIARALMPDPELLLLDEPAAGLDLGGREELVSRLSALADDPMAPTMAMVTHHVEEVPEGFTHALLLRRGSVVAMGKVDEVFTEEHLTRCFGLPLTVERQSGRWYARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEX0</accession>
    <name>A0A1H6CEX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71412">
        <property type="protein sequence ID" value="SEG71412"/>
        <property type="gene ID" value="SAMN04489712_109268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294860" evidence="3">
        <location>
            <begin position="28"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG71412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="127" mass="13655" checksum="77AA9ABF2081B26E" modified="2017-01-18" version="1">MIFLGLLVTAAALATGIAVVLANDGAAQLSAFGEPVPGVTAQWHVFIAGVVVATVFIAGLTAFMFGVNRSVRTRRELRYLREEHEESITALEMEKRQLQRELARARREAASGAVAPPPQAPHQPVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJJ3</accession>
    <name>A0A1H6CJJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73139">
        <property type="protein sequence ID" value="SEG73139"/>
        <property type="gene ID" value="SAMN04489712_11076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="246"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="37095" checksum="D7163F4B2ED9C03E" modified="2017-01-18" version="1">MAGTVVSPSQDELVGCVDAAVQAPSIHNSQPWQFLLVPGGVEVHSDPSRRLPAVDPQGRSMHISLGAAVLNLRLAVRYLGRREHTELLPDPRDRRHVATVRAGERYTPGGDDEELYEAIPHRRSNRSPFEDVPPPPGALEPLITAAAAEGAELRFLDQDESDFLLYLALMADERRRESPAYRRELYNWVTDDPYRDDGIPLAAVGPWTEGGPVSLRDLAPDREVPGRASVRLEREPTVAVLTVRGEDAPPQWLRAGQAMQRVWLDATRRGLAVSVFTTPLEDPELRDALRRPSDPITYVAFRLGYAPPAAATPRRPVDEVIAYTRPVPIRPPHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMF7</accession>
    <name>A0A1H6CMF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73843">
        <property type="protein sequence ID" value="SEG73843"/>
        <property type="gene ID" value="SAMN04489712_110161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG73843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="232" mass="27198" checksum="48519EE1E03F25E5" modified="2017-01-18" version="1">MHPPTTEDPIRLFYVDDSGASDIGIISYSWIQFSARDEPSVTGWWHDLRRELDLRYQVPGEVEWHSTHMVRGDGRPSRNEEFNQSRSMRREAMEFVLSMISACEELRVGTVYRHTGKNGREYYTEKMALYGRMISHIDLRLAGTRERAMMTVDGREWDRDRLEQGYRTARPRNFTGPPVLESTERMPLLQAADIVAWTTYQSLRRYPGKELISSWYDTYLRHRDVNGGPQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQS4</accession>
    <name>A0A1H6CQS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylase of polypeptide chain release factors</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75360">
        <property type="protein sequence ID" value="SEG75360"/>
        <property type="gene ID" value="SAMN04489712_11125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="198"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="380" mass="41694" checksum="6B840D88884C0D38" modified="2017-01-18" version="1">MRTEELVHWTEAGQARSARWRSENGAPPPKRVTIADDRMKADVAYRLACEGTAILWRGDFHNARQLLQAMSRRLDRPRRRRRPGASEVPSPAQAFHLHRMAQAQRARTLGMLLVPLDSGYGVPLRRSPDVRQACLEAYGPADEPSLVSLRELLGLVGAHEWRRKGVEVPALGDRIHPHYGVFSPVRGEYVDLVARAPLPSAPAPAFDIGTGTGVLAAVLARRGVARVVATDADPRALGCARENLDRLGLADRVELVRADLFPPGRARLVVCNPPWIPARATTSIERAVYDHDGRMLRGFVEGLADHLEPGGEGWLVLSDIAEHLGLRSRAELMAAFTTAGLTPVDRLDIRPRHPKVSDSTDPLHAARAAETTSLWRLAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CR37</accession>
    <name>A0A1H6CR37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75472">
        <property type="protein sequence ID" value="SEG75472"/>
        <property type="gene ID" value="SAMN04489712_11143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="11230" checksum="0108BCF02EF70751" modified="2017-01-18" version="1">MGRSRISVNVDLPGRDPNASVTLPLDERANCRAFCVTHPEGAEPVLAISHGGVNVMLTPDKPGRVTAGDVAVARALLEAVTSYVTDVERLHDQNARSSGSPGAGRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRT9</accession>
    <name>A0A1H6CRT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Para-aminobenzoate synthetase component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75711">
        <property type="protein sequence ID" value="SEG75711"/>
        <property type="gene ID" value="SAMN04489712_11174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG75711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="213" mass="22618" checksum="D1E8F0D8BEA60F10" modified="2017-01-18" version="1">MAVHVLVVDNHDSFVFNIVQYLLELGADCTVKDRSDVTPGDAAGVDGVLLSPGPGHPADSGVCLDLVHEAERRRLPLLGVCLGHQIIAHVYGAKVSRAPELVHGYTSLVGHGGEGVLAGLPDPFPATRYHSLAVEPAGFPQALEVTARTPDGVIMGLRHRDRPIEGVQFHPESVLSEGGHRLFGNWLATCDPATREPSRPAPRGPSENFGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRV4</accession>
    <name>A0A1H6CRV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized membrane protein YeiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75365">
        <property type="protein sequence ID" value="SEG75365"/>
        <property type="gene ID" value="SAMN04489712_11126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007349">
        <property type="entry name" value="DUF418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04235">
        <property type="entry name" value="DUF418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295137" evidence="2">
        <location>
            <begin position="30"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="DUF418" evidence="3">
        <location>
            <begin position="170"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG75365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="33569" checksum="88A9240CE2A127AB" modified="2017-01-18" version="1">MVRGLALCGILSANIVAITGIQVWGTAGADPGLVGHLYETLVHQRFFPVFSFLFGLSAVLFLGAARGGMEPPRTVLLARFGFLLPFGLAHQVLQPGEVLVSYAVIGIVFGLPASFLPRRAVLAGGTAATLASLLIAEGGVTLIPGLFLLGMAAGAYDVPGLIARRSGRIAAAFYPTALLAAGLNVWQVTMGAAAFDSPLPAAAGAVTGAAYAIGLLMLLRRERLHAALSFVLQPLGRLALTNYITATPLVIAADHLLDLGGHPRVAAVVGTALAILALQVLFSRAWLRHHRYGPLEWAWRCLTWWRLVPNRPRPAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRY0</accession>
    <name>A0A1H6CRY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75789">
        <property type="protein sequence ID" value="SEG75789"/>
        <property type="gene ID" value="SAMN04489712_11184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="303" mass="33167" checksum="BF62602532EFE4AC" modified="2017-01-18" version="1">MSARIDSYVPAGAPPAWERVAAEVRRVVTVAEPLTPYRAGELMSVLARLALFADGQGCRADAQVWLSREFIERFITVGCTDVSAATRGNYRSKLLRLREAVCGPDCRSGKPVKLSASDTSKPYTPAEMTTLWTWAQGQPTEELRRGCTLLLALGRGCGLDSPEVIPLRAHDVRRHDNGAVVVTVRGRRERLVVCRRPWERVLAEEAARFRGQAAHLFRPGLHARAKNTITGFLARTHDAPGTPALKMSRLRTSWLVELIEGNLPLPVIVAAAGVDTLHGLSRVLPYVKGASTDRAAELLRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CU31</accession>
    <name>A0A1H6CU31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FG-GAP repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_111148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76307">
        <property type="protein sequence ID" value="SEG76307"/>
        <property type="gene ID" value="SAMN04489712_111148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295214" evidence="4">
        <location>
            <begin position="25"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG76307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="602" mass="61479" checksum="7FF18CBD7CA6FD19" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CU95</accession>
    <name>A0A1H6CU95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76105">
        <property type="protein sequence ID" value="SEG76105"/>
        <property type="gene ID" value="SAMN04489712_111123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007410">
        <property type="entry name" value="PCuAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36302">
        <property type="entry name" value="PTHR36302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04314">
        <property type="entry name" value="PCuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295206" evidence="1">
        <location>
            <begin position="32"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="17901" checksum="75513F6118460508" modified="2017-01-18" version="1">MLNIRIIVPALPLLALPLAACGSGDDTTGAAATVTPAASASASAPKEALTITNPWVKTVDKGMTAAFGTITNTTGAEVTIVSAATPASPKVELHEVAGSGGEMKMRPKQGGFTVPAGGKLELKPGGYHIMLMDVTGPIEPGRQVAFTLTLADRSTIRFSALAKDFNGGNETYAPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVS3</accession>
    <name>A0A1H6CVS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77064">
        <property type="protein sequence ID" value="SEG77064"/>
        <property type="gene ID" value="SAMN04489712_111243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="217"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG77064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="34760" checksum="72F747B50A719DC3" modified="2017-01-18" version="1">MRRRVVFVAFEGFQMTDLAGPADVFATADLLVPDGGYRTEVVAVRAGAVAALNGIPVLAGGALREVTGPIDTLIVVGGLSVPACLDDRELVGQVARLADTARRVASVCNGAFVLAEAGLLDGRRATTHWLVARDLAALYPRVEVDADPIYIRDGDVWTSAGVSAGVDLALALVADDHGHALARDVACGLVVYLHRPGGQSQFSTAMRALAPPREPFRELQAFIDAHPADDLSVPALARRTGMSERHFSRVFTAQTGLPPGRYVELSRADAARRLLEITDHPLERVARECGLGSPETLYRVFRRHWRISPGDYRRRFHLKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZB8</accession>
    <name>A0A1H6CZB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78053">
        <property type="protein sequence ID" value="SEG78053"/>
        <property type="gene ID" value="SAMN04489712_11220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG78053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="31236" checksum="66A5735B8AE48D95" modified="2017-01-18" version="1">MTPDMLDKLRRFRETALAEGIPPDDIERWVEMARPCAILKHKGDGPVVGRLGGPLMLPADAPDPWCKLAATIDLAALPEAVTDLPLPSDGQLLLFANPDPEMIDEGNLGSALFIPPGTPVQERQVDLDPEWISEPHEREFLEGLLYLEADVSLPYHSNVRDLGLPAGSKSPAAHPHAYELLDVWMEIQHGSGYLGLQLGGYAEDEYREGDPSMAAGREAARAEARGELPISEADVDPRDWVCLAQWLHGITGLEMALYSWSIARQDLAARRFDRVYATMTWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D098</accession>
    <name>A0A1H6D098_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG77986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77986">
        <property type="protein sequence ID" value="SEG77986"/>
        <property type="gene ID" value="SAMN04489712_11210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="356"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG77986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="648" mass="68343" checksum="C907D788B7CC1290" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3T5</accession>
    <name>A0A1H6D3T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyisoprenoid-binding protein YceI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79455">
        <property type="protein sequence ID" value="SEG79455"/>
        <property type="gene ID" value="SAMN04489712_112218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="15"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="21125" checksum="6F433051D4B023E0" modified="2017-01-18" version="1">MPAELVEIPGYVAGTWDIDPVHSEVGFTVRHLMISKVRGRFRTFEGRIVTAADPRESSVTATIDLSSVDTGNKQRDDHVRNADFLEVDKYPAMTYRSTGLRPDGDDFLLDGELTLKGVTLPVPLRLEVHGFGPDPFVPDPFAGARVGFTATGEINRMDFGVSYNGPIPGGGVGLSEKVQIVLEIQAALRTRATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D483</accession>
    <name>A0A1H6D483_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA domain (Dynein-related subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80071">
        <property type="protein sequence ID" value="SEG80071"/>
        <property type="gene ID" value="SAMN04489712_1138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="42"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="40717" checksum="F4F76FA9E68DEE07" modified="2017-01-18" version="1">MNTTDPLAAADELNRRAGAWRSEPATDPNIEALALAVSANLPVLLWGEPGIGKSAGMRQLADALAVPLETVIASVHEPSDFAGLPVIGDDPAADGVPMAPPDWAVRLARAGRGLVFFDELSSAPPAVQAALLRVVLERRVGSLALPEPVRVVAAANPPSSAADGWHLSPPLANRFVHLRWTHSPRTVARGMAGTWPQVSIPLVDAAKIPSAVARARGAISGFLTARPGLAHHLPADAEARGGAWPSPRTWEMALRLLAVGYAAGAGREAVAAAVIGVIGDGAGIELLSYLEQLDLPDPDRVLADPGSFDLPERGDRQLAFLTAVVAAVQGDLTRRRWEAGWTVLAKAVDAGVPDVAARAAVDLAALRDTAWPVPAGIDGFVELLQLSGALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4C9</accession>
    <name>A0A1H6D4C9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11337</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80197">
        <property type="protein sequence ID" value="SEG80197"/>
        <property type="gene ID" value="SAMN04489712_11337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295505" description="Alpha-L-rhamnosidase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="6">
        <location>
            <begin position="355"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="5">
        <location>
            <begin position="536"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="7">
        <location>
            <begin position="637"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="8">
        <location>
            <begin position="966"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG80197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1052" mass="114432" checksum="719C5611F9E612F9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5J4</accession>
    <name>A0A1H6D5J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80055">
        <property type="protein sequence ID" value="SEG80055"/>
        <property type="gene ID" value="SAMN04489712_1136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="377" mass="38558" checksum="92223008FFAD6FC0" modified="2017-01-18" version="1">MTEPTPVRCPAIEVPDVPRADPADLVPLLARLASADPVTGDEPFPLGTLRADGRVDLCKQGLGPDGVARLLPVAAASPHARHVLLGTNGIGTEGARALAGALTSGHGLETLYLGCNRIDADGAAVLAERLADDGTVRALWLKRNPIGDAGVRALAAMLRANTTVRTLDLVNTGLTVDGLRALLEVLADRPRPLERLFLGGNGLAAEDADVLAALVRDAGVRELYLPANHLGDAGAATLAAAVSTARPVLLGLGGNGIGPDGARALAGALEGIESLDLGRPPSERSLGAPANTTGDEGAAALAAALPGSPLRRLELRHTGITGRGAKALLARVPDGTRLEYVGLGPGVPRKVKRAFAPRLRPAARAHPDLHAIGSVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9V1</accession>
    <name>A0A1H6D9V1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81864">
        <property type="protein sequence ID" value="SEG81864"/>
        <property type="gene ID" value="SAMN04489712_114161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="114" mass="11977" checksum="DE96C5DAF78D8578" modified="2017-01-18" version="1">MTILVTGATGKVGHNVLTELLAAGRAVRAIFRPSEQAGLPEEVEVLHAEALNIGYAPVAQRGVPALEPSRLAHVSCAYLSAETFSPDPAWMDGSAVRDRAAVTRARARPGCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBE1</accession>
    <name>A0A1H6DBE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tn3 transposase DDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_114148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81806">
        <property type="protein sequence ID" value="SEG81806"/>
        <property type="gene ID" value="SAMN04489712_114148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002513">
        <property type="entry name" value="Tn3_Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01526">
        <property type="entry name" value="DDE_Tnp_Tn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DDE_Tnp_Tn3" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG81806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="77" mass="8449" checksum="FBB8555239D517E2" modified="2017-01-18" version="1">MVLWTTRYIDAAVDQLRAEGHEIVGEDVARLSPLKHRNLNVLGRYSFTASTAAGGDLRPLRDLAAPELDEDDDGGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBW4</accession>
    <name>A0A1H6DBW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82778">
        <property type="protein sequence ID" value="SEG82778"/>
        <property type="gene ID" value="SAMN04489712_11583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="386" mass="40196" checksum="66ED843AEEC06608" modified="2017-01-18" version="1">MLLAGDERGLRSDRPASGPQEGLPWRPLSPLSIEAPHVLSDVAASSPEDVWVVGQAHGRPLAARWDGTSWSVPPGPPPSAALIGAGLEGVAAARTGHAVPDGSGPAGHTDLRNEPAGRDALAEVIAVGGAYDRLLGTEIPLIRHWDGTGWAEMAAPALPDADSAQGYVLTDVTMVAPAEAWAVGHGSGRGNGLVALHWHHDRWHPAGLPDIAQGKLLAVCGTSPWDVWAVGAADRAGLVVHYDGRAWQRIRTPATRFPLTDVTAVSPDDAWCAGGGSVLRWNGRKWSRVKTPIESANTVTAVSATDVWVGGAQGELAHFDGHRWTWMTAPGDLHGTAVWRSSTVALPTSAPGAGIGAAVWMVGSRRLGGSVSTPQHRSFTSQSGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DC26</accession>
    <name>A0A1H6DC26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_115126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83027">
        <property type="protein sequence ID" value="SEG83027"/>
        <property type="gene ID" value="SAMN04489712_115126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295821" evidence="1">
        <location>
            <begin position="43"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="12999" checksum="676B378787B3E655" modified="2017-01-18" version="1">MDSERTQDVPTRGRWARRAATMLVGGAIAAGGLAAVAAPAHAAPSGCTLTNQWTGYQATCTEGDGLYRAYARCTKLIFNSPALPRRVYYNEYGEWATPGAGSISTARCPSGAWTEYGLIQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DC30</accession>
    <name>A0A1H6DC30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B3/B4 domain-containing protein (DNA/RNA-binding domain of Phe-tRNA-synthetase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82789">
        <property type="protein sequence ID" value="SEG82789"/>
        <property type="gene ID" value="SAMN04489712_11585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B3_4" evidence="1">
        <location>
            <begin position="67"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="234" mass="25910" checksum="D9DC222741557038" modified="2017-01-18" version="1">MLAEIWVEDAVQKLRPDFAVLAMTAEGLANDASDDVSADWLHKAGLRAAEAAQARSAQGSADDPHVLAWREAYRGFGAKPQRTRPSVDALLRRVDQLPAINRVVDAYNAVSVEYALPIGGEDLDTYQGTARLVRARGDEGFETTAGGAPAIEHPDAGEVVWRDDQGVTCRRWNWRQCVRTRITETTENALFLLERLEPYPLERLHAAADDLAARLRTIAPEVRIRTRLIGDGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DC74</accession>
    <name>A0A1H6DC74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82870">
        <property type="protein sequence ID" value="SEG82870"/>
        <property type="gene ID" value="SAMN04489712_11599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="19815" checksum="2D483AD5AA571A5D" modified="2017-01-18" version="1">MIITTDRTARAVKDPRELLGYRPGLFDTLAAYVAKHQQVTLPYAEGVVEQTLVWFKACADNPTVRLGMSESVDHGWHAFLLHSQEYAEFCERMFGTYFHHVPPRPGQSMTEQEMAATLPALYATGYPVDESHWNGVAYGCCPPDPCTRAKPENKPDATTAATNCRGGTGAPPPGAFATARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DF77</accession>
    <name>A0A1H6DF77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83732">
        <property type="protein sequence ID" value="SEG83732"/>
        <property type="gene ID" value="SAMN04489712_11657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="292" mass="31371" checksum="7C3162591F983EB2" modified="2017-01-18" version="1">MATASVHGLRVGYDVIGRGRPWVLTPGGRDGRHAPGLREFAEALAERGNRVLIWDRPNTGESDVCFAGTSESAMQADVLAGLLRRLGMAPAVLAGGSGGSRVSLLTAARHRDVAAGLALWWISGGVFGLMSVGLHYCGGSIRAAWDGGMAEVAALPEWAEVLARNPANEQRLLDQDPREFIATMERWLAAYSPSDAELVPGLPNAAARALDVPALVFRSGTRDIHHRRETSERIARTLPNAQLVEPPWGDAEWPERQAARTCGQAPGLFVRWPLLAPILQDWAEEALPPFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DH58</accession>
    <name>A0A1H6DH58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_116124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84005">
        <property type="protein sequence ID" value="SEG84005"/>
        <property type="gene ID" value="SAMN04489712_116124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG84005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="20686" checksum="7E6B6400957C8758" modified="2017-01-18" version="1">MRHARDGAAAAMNAASRVLVARGKYEPQELENPDVSWGQRTRDGVWAPTRDGQRIHIGIECSAGDQPATVLRPSLRVFVGVEVDTDIVAQTTASGVRLLTVLHGPDAPTEFRFPLSLAEGLALEAMPSGGYDVVHLRYGATVGRFYNPWASDSMFRPVKADYALDGSTVIMRVQHSGSYYPVVADPLYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIK9</accession>
    <name>A0A1H6DIK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase, MSMEG_4879 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_117136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85098">
        <property type="protein sequence ID" value="SEG85098"/>
        <property type="gene ID" value="SAMN04489712_117136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019910">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_4879"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03564">
        <property type="entry name" value="F420_MSMEG_4879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="34163" checksum="2AE9CD049052D7F1" modified="2017-01-18" version="1">MRVGVMVGPERGDSARKVARMIEDVTWAENAGMDTVWVPQIPTDFDALVAVALMGARTERIELGTAVVPLQPQHPIALARQALSAQAATGGRLALGLGPSHHWIVRDMLGLPYEKPAAFTRDYLDVLDVALRGPGEVDVENETFTVHNPLGIGPVAPMPVLLAALGPVMLRLAGERADGTVLWMADERAVAEHVVPRITKAAEEAGRPAPRIVAGVPVCLCRPSEVEAARERANRILGEAEISPNYQRLLEYGDARDIGDLCAAGDEEAIAARLRRFADAGVTDLSVRLLPIGEGRDALVASKRRTREVISQIAAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKG1</accession>
    <name>A0A1H6DKG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85609">
        <property type="protein sequence ID" value="SEG85609"/>
        <property type="gene ID" value="SAMN04489712_11844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="257" mass="27486" checksum="DBCA8EEBA0516F48" modified="2017-01-18" version="1">MPEAFYLPLGEGRYEPTRATESPWDSGAQHGGPPTALLAHVIDGTAGADMRLARVSVDFLGPIPRHEVRVEVSPVRPGRLISLSEARMIAGDRTVVVARAWHIATGPPPPVTGERLRPPALSEPGTGPLRPDLAGWGYGRAIEWRYTHGGHGTLGPAGVWTRVRIPLIAGEKITGLARTLIVADSANGLSAVLPMQEWLSIPPTMTATLARVPAGEWVHMAARTRLSDDGLGIAHATLCDPDDHLGEVTQPLLVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKL3</accession>
    <name>A0A1H6DKL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85822">
        <property type="protein sequence ID" value="SEG85822"/>
        <property type="gene ID" value="SAMN04489712_11886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="30038" checksum="C5A2A8BDA5FAB1F7" modified="2017-01-18" version="1">MPGRPVGEVTRGTTAPNRLRRIDLWIAATQVRALRATARPLAVDLGYGASPVTTVELYSRLRVVSPRLEVVGIEIEPDRVRAGEEFLAAVRPAGDYGDLSFRRGGFELPVDRPPVLVRAFNVLRQYDEAAAWKAWDGLRSRLAPEGVLVEGTCSETGRRAVWVTLGPEGPRTITFAAHLPSLPRPSELAERLPKTLIHRNVPGEPVHALLTEFDRCWAVAAPQSVFGPRARWIEAVTLLARSHPVVTRPPLGGRTRWRLGEVTLPWSAVGPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL76</accession>
    <name>A0A1H6DL76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-asparaginase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_118111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85934">
        <property type="protein sequence ID" value="SEG85934"/>
        <property type="gene ID" value="SAMN04489712_118111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="334" mass="34860" checksum="DBA2F04779CCB3B7" modified="2017-01-18" version="1">MIIEVVWGETLEANPVLVEVERSGFVESRHRGVVVGLGADGRTLARLGAAEEPILPRSANKPIQAVAMLRSGLALADELLALAAASHSGEDFHVEGVEKILAGAGLTAEALRCPASWPLEPAVMAEVARAGGTRSRLRMNCSGKHAAMLATCVRNDWPTGSYRAFDHPLQQAVREAVADLTGERPAVTGVDGCGAPVFAVSATGVARAFRALVTAPPGSPERRLADAMRAYPEWTSGTRREERRLMDAVPGLLVKCGAEGVDAFALPDGRAGAVKIDDGAMRARTPVTVALLRALGVDGGPELDELAALPVHGGEEVVGTVRAAPSFLAALPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQJ1</accession>
    <name>A0A1H6DQJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_120142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87490">
        <property type="protein sequence ID" value="SEG87490"/>
        <property type="gene ID" value="SAMN04489712_120142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="11236" checksum="03102AE3D093C956" modified="2017-01-18" version="1">MTDRLECPDCGGRGEQQLGPVNVRCLFCGGLGYVGDDNEPAERDADDGADVHPMEAEPVWEQLGARAVPGCSVCFGAGTVVSLGGDVRGGVPTKMVRLPCPECAADRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTP3</accession>
    <name>A0A1H6DTP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88717">
        <property type="protein sequence ID" value="SEG88717"/>
        <property type="gene ID" value="SAMN04489712_12265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="300"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="41600" checksum="C4332409EC002F4D" modified="2017-01-18" version="1">MGRTYTGFLRGAPPRPLLRFISLVGVAWAVPAVVLSPLPVARTVLVTGFILVWGRQAARPWRPPAGSVPFLALVTLMPLLLAPTAVGDPGGFRPFPFAEGSYADGALAVAAAPVWIHLAVLSGGRDLAWCVPVTLLLAPARHLLTGDFPLWPAWIMWEVGFLLLGSVFRVHGMLYEARLRLDREAVAEERRKIAREVHDLVGHGLGAALLNIGAARLAAFRGDTRATIEALEEAERAGRQSVRDVHRGLVLLRDPARAEGATARALPTAEDIGELVEELRSGGLAVDLTTRGDLGAVDPVTGLAIFRVVQEALSNTARHAPGAAASITVDVGERFVRVTVADQGSTAAGGRSAGGGLGLIGMRERVTALGGTLWAQPEGSGWAVHATIPVGRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWZ3</accession>
    <name>A0A1H6DWZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine/homoserine efflux transporter RhtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89788">
        <property type="protein sequence ID" value="SEG89788"/>
        <property type="gene ID" value="SAMN04489712_12465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="150"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG89788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="31920" checksum="553651C766C91E10" modified="2017-01-18" version="1">MTPLAWAALVVVYLVWGSTYLGIEIVIETIPALVSGGMRFLVAAALLAAFLAVRHGPGVLRVSRRQLGSAALVGVLLLTGGNGMVAVAQQHISSGLAALLVAAVPLWLVMLRTLGGDRPPTATLAGVVTGFAGVALLSVLSGGEASGSVLGMAVVLFASLSWAVGSFLAGRLAMPGSSFTASVYEMAAGGLALLAIGFGRGERVDLTAVSGRSWLALGYLVVFGSLLAFTSYAWLLGNAPLSIVGTYAYVNPAVAVLLGALVLGEAVTWGMLAGGAFIVLGVGIVVSTESRPRPAALQRRPDDAPAVEDVALETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYJ4</accession>
    <name>A0A1H6DYJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, PucR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89705">
        <property type="protein sequence ID" value="SEG89705"/>
        <property type="gene ID" value="SAMN04489712_12435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="332"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="43963" checksum="ACABEE616E8B695E" modified="2017-01-18" version="1">MQAAALLRHHRLDLATEIVDEVAAQVPEYSWQTDPERRAALVETIRRTVAEFADLMGGPATGWPRHMLDLFGEAGAQEARAGRGLDRLQSALRAGARAVLRWLAVQSERLRLPRSMYRAFAEAVFTSLDEFADAAAEGHRRELAKQGDDRVRHRVRLLSLLVTEPSVAPEVIADTAAQADWTVPRTTAALVFAPLRAEVSGPHAEEPVLPSLPAEVLADVRGARPWGVVPDPDRPGGLPYLAELPSPWMMVIGPTVTVDKAAASLYWAKQTLGLVERGIIAWRPGDGPVVHWADHLPTLVLFQREELPRMMAERLLAPLLKLRPREAERLGATLLACLQHGFNVKGAAKTLHVHPQTVRYRINQLQDLFGEDLHATDRRLEMEMALHAWLATMSAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZG9</accession>
    <name>A0A1H6DZG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90722">
        <property type="protein sequence ID" value="SEG90722"/>
        <property type="gene ID" value="SAMN04489712_12719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="70" mass="7632" checksum="AE5C2A840E6AB959" modified="2017-01-18" version="1">MNPLHDPLITYLRAVIGDRIHRARTADRGLGVSAIEWAIITGMLAVIAIAIYATIRGRISDAANRIDTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0A1</accession>
    <name>A0A1H6E0A1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG90967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90967">
        <property type="protein sequence ID" value="SEG90967"/>
        <property type="gene ID" value="SAMN04489712_1281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="95" mass="10650" checksum="2112218E9249AA30" modified="2017-01-18" version="1" fragment="single">QYCSKDFEAVCRRLGVTRSRAAVGTSADNAAAEAFNATLKRETLQGAHHWPDTRTARLAVFRWITRYNTRRRHSRLGHTSPIDYEKTTGSLTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0Z5</accession>
    <name>A0A1H6E0Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L,D-transpeptidase catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91288">
        <property type="protein sequence ID" value="SEG91288"/>
        <property type="gene ID" value="SAMN04489712_12881"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296387" evidence="3">
        <location>
            <begin position="36"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="159"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="28338" checksum="0ECC5DC6F65DBA12" modified="2017-01-18" version="1" fragment="single">MTDRSPWARPAVARPARRVATRRGALAGIAAVAAAAVLVTGCGGGEHKPQTGRTSAPDLSKLPQATTFTTLRGLPQDPHPFAETGGTVVNPAVTLPVSAEPGGPPVVALPDRQLDGPTWVPVLEAKDGWLRVMLPSRPNRVTGWIRQEGANLTAAHSPYVVKVDTGERRLTLVRSGRKIGAWTVAVGAAKTPTPAGRTFLLGLLKPSDPKPSPLIMPVGAHSETLDTFGGGPGTVAFHGWADESVFGRAVTHGCVRVPDDALTRLSKVPLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1D5</accession>
    <name>A0A1H6E1D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional activator domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90735">
        <property type="protein sequence ID" value="SEG90735"/>
        <property type="gene ID" value="SAMN04489712_12723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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</entry>
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</entry>
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</entry>
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</entry>
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    <accession>A0A1H6E7Z6</accession>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
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    <name>A0A1H6E8K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94148">
        <property type="protein sequence ID" value="SEG94148"/>
        <property type="gene ID" value="SAMN04489712_14322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="75" mass="7731" checksum="1A0CCFA1D72E9007" modified="2017-01-18" version="1">MAAHDLLAPDRYAARGQSTQRVFAAALSGCLSLTPAYLCSAELVVPPELIITNGTEAAAKIGGLPISPARRPTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAM9</accession>
    <name>A0A1H6EAM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93966">
        <property type="protein sequence ID" value="SEG93966"/>
        <property type="gene ID" value="SAMN04489712_14212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="103"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="539" mass="57549" checksum="7246FC082DAF7D58" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAY1</accession>
    <name>A0A1H6EAY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine catabolism regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000047">
        <property type="protein sequence ID" value="SEG94401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94401">
        <property type="protein sequence ID" value="SEG94401"/>
        <property type="gene ID" value="SAMN04489712_1479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="474"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG94401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="538" mass="57243" checksum="A7403544D5007F16" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB08</accession>
    <name>A0A1H6EB08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_14215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93975">
        <property type="protein sequence ID" value="SEG93975"/>
        <property type="gene ID" value="SAMN04489712_14215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="14"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG93975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="36787" checksum="9AC1B49FEC54CA17" modified="2017-01-18" version="1">MPSGTDSTTDLLVVRGLRTTLRTPRGPLAVVDGADLRVPRRTTVGVVGESGSGKTMFARSLMNLLPAGAEVTAEELTFDDRELDPRRPPHRHFWGTEISMVFQDPMTALNPVRTVGAQICDPLRVHQGMGRGVARRRAAELLGHVGIPAPWSRLDQYPHELSGGMRQRVMIAVAISCEPKLLVADEPTTGLDVTVQRQILALLRRLKDEHGMAMLLISHDIALLADEVDQVGVMYAGQVVEHTDVAQIRGKAVRHRYTRALLQAHPDVNAPARTRLESIPGGPPDLLAMPEGCRFAARCEHAREICRATAPQPTRDPRTGAAFTCHFPHEPAEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECD7</accession>
    <name>A0A1H6ECD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000055">
        <property type="protein sequence ID" value="SEG94931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94931">
        <property type="protein sequence ID" value="SEG94931"/>
        <property type="gene ID" value="SAMN04489712_1555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="18190" checksum="EC5F15CF3235EB32" modified="2017-01-18" version="1">MDFDGGEIDVTWQLQRVRRELLHRETKIEASDATLPLSDICLTALRLRRKRRDQSREAAGKDWTDTGLIFTTRTGQPINPHNFNRSFDQRCAKAGVRKITVHDTRHTCATLLAALDVHPRVAMRVLRHAQIAVTMEVYTEVSDAKTLKALKRLGKQFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECG3</accession>
    <name>A0A1H6ECG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase YagS FAD-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94485">
        <property type="protein sequence ID" value="SEG94485"/>
        <property type="gene ID" value="SAMN04489712_1484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="313" mass="32493" checksum="E38F8CC7476D1430" modified="2017-01-18" version="1">MTTLEAVAKAVRDTGGELRAGGTDVMTRATRPPVDLLSVPGLRGIVWRPDGSARIGALTTIADLLADDRLTAAYPALAATAAAIATPQIRNVATVGGNLLQRNRCWYLRNPAFTCHQTGGDTCPAREGAHLYSAVIDQGPCIAPHPSSLAVALLTYAATAEVHGRSPLGIAELYGDGGDPTCDHRLESGEILQAVLMPAPTPIERAAYRRATAREMAEWPLVEAVARLTLDGDTITTAAIAVGGVARTPLFLPEVADALLGKSATEETLAAAADLATARCSPLPRSAYKVALLRATLIDVLTACSAPPPPATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECL7</accession>
    <name>A0A1H6ECL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000059">
        <property type="protein sequence ID" value="SEG95013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95013">
        <property type="protein sequence ID" value="SEG95013"/>
        <property type="gene ID" value="SAMN04489712_1591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG95013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="234" mass="24129" checksum="201766EA10B8328D" modified="2017-01-18" version="1" fragment="single">MNEHTTGGLAAVTTHPGTVQVIVPDLGEDAPTWETLEETLATLRGWESDPPRQDLPPMRLPAPIAGGAALEALQRTLPAVLAVTGQRAAAAGLGTLRSPAEPGNAWGIAAGRMTERMPLRIIYLPAADAAVLARLPGALAAGDPDVADAAGQVLDAHGIIGGEDPAARLADHARRLTGLLDVELDDAERALADAIAATPATDDVVLTCEQHAVYRPLAARLLRTITGTSDPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SIE0</accession>
    <name>A0A1H5SIE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50382">
        <property type="protein sequence ID" value="SEF50382"/>
        <property type="gene ID" value="SAMN04489712_101225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF50382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="42501" checksum="4370AE6EFFC5E0AF" modified="2017-01-18" version="1">MSLPVSVGQARAHVLRKQGLAGDGLKSVPAAVDATGGVYGTAPTCYLSCAARIPGFQVADLDHELYTERSVVRLRAMRGMAYIEPLALLPALFACTGEARDKTLKRVAKYAEMTEVQTLALADRIEAALEGCPPMTVKEIREALGGDLPGNRNALQMTVALLGRHGRIVRTRARGTWRSDLYPYARWTDWLGAPVEDMDPAAARAEVARRYLRAYGPATAEDLKWWTGWTKRDTLPALAALGEEATPVSLDGTDAWALTDELDALTATSPGDGRGVRLLPVWDSYFMGYATKPAGRARQVREEDYPRVYDKIGNATSVVVRDGMAAGVWELDADGGTLTVAPFDEELPWDDVAAQAAALGQAIGTELKVVRAHVPGPLSDGPRNTFLSPISLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SJY8</accession>
    <name>A0A1H5SJY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-monoxide dehydrogenase medium subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50077">
        <property type="protein sequence ID" value="SEF50077"/>
        <property type="gene ID" value="SAMN04489712_101213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF50077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="292" mass="29989" checksum="0556FFF60264BAA9" modified="2017-01-18" version="1">MKPPPFDYEAPRTLGETLDALAGGGKVLAGGQSLIPLLNMRLAAPDRLVDVNGVAELDTLEVTAAGVRVGALARHARVERSGEAAAVQPLLRQALRHVAHPVIRNRGTVVGSLVHADPAAELPAVLALLGGTVEAASSGGRRTIEAAGFFTGPLECALAPGELAVSAFFPALPPQTGTAFAEVARRHGDYALVGVAALVALDDDLRVRAARAAYLSVADTPLVLDLTEPATRGQAGRPPGAADWSLAGADAAGRVRPDGDIHAGADYRRHLAGVLTERALAEAARNALPGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SLJ0</accession>
    <name>A0A1H5SLJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsZ</name>
        <name evidence="11" type="ORF">SAMN04489712_101267</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51482">
        <property type="protein sequence ID" value="SEF51482"/>
        <property type="gene ID" value="SAMN04489712_101267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="9">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF51482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="490" mass="49541" checksum="D4D9667F5DEACCE1" modified="2017-01-18" version="1">MAAPQNYLAVIKVVGIGGGGVNAVNRMIEEGLKGVEFIAINTDAQALLMSDADVKLDVGRELTRGLGAGANPDVGRKAAEDHREEIEEVLKGADMVFVTAGEGGGTGTGGAPVVANIARSLGALTIGVVTRPFSFEGKRRAMQAEAGIETLRDEVDTLIVIPNDRLLSISDRQVSVLDAFKAADQVLLSGVQGITDLITTPGLINLDFADVKSVMSGAGSALMGIGSARGDDRSVAAAEMAISSPLLEASIDGAHGVLLSISGGSDLGLFEINEAAQLVSNAAAPDANIIFGAVIDDALGDEVRVTVIAAGFDEGRPTKPAPGADTRRLPASANRSSTAPGPGTAQGNPIPTRVGRTDPPAAPPSGHQSVAQAAAAPQSAPAQPAPAPAREETSAAREPGAGSGDASAAEPSSAKDDATRPAASDAAAGSGQAKAERDPGAAVPPRPRTPPEQPPARMHAPESDGGTGPRRRPVVFDEPDDDLDVPDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SWS9</accession>
    <name>A0A1H5SWS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein, tetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54301">
        <property type="protein sequence ID" value="SEF54301"/>
        <property type="gene ID" value="SAMN04489712_101373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C" evidence="1">
        <location>
            <begin position="73"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF54301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="189" mass="20731" checksum="A4F5744115E4AD89" modified="2017-01-18" version="1">MPATGPRTDALLAAALAVLAERPYQEFGYAAVAERAGIEVEQLRHRWAHPAELAVEALVEALGPPGSEPSDAGLRAELLTVTTRLAHEFAVYGQALVGLLAALRHHPELDRAFRERFLLPRTECARRALGRATLRGEIRPEADPRLVLSLVPALFTFRVLLRDPTPDERLAERLVDAVLMPLLSRGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T204</accession>
    <name>A0A1H5T204_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske-type oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_101450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56806">
        <property type="protein sequence ID" value="SEF56806"/>
        <property type="gene ID" value="SAMN04489712_101450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <feature type="domain" description="Rieske" evidence="9">
        <location>
            <begin position="52"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF56806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="341" mass="38558" checksum="E093C8238124AA0C" modified="2017-01-18" version="1">MTTPEIAPSTGPRNIAGLPMPSDPGLLFDPSRRTRVIRRPEGRFPFPVPNGWFIVARSGELRAGDVLPLYYFGRDLVLFRGQDGAPYVLDAHCPHLGAHLAVGGQVEEGCIRCPFHGWSFDGASGRCVDVPYDEHEHIPRRAEIRAFPTVERNGMVWAWHHLTGGEPFYEVPQVPEFDDPDWSPIVVREFEIATCCQEMAENNVDRAHFKYVHGTDAIPEEEFHIDGAYKRAVGAGGDFVREGYGLGLGVLRLKGWTTFISSTTPIDEDNVHVRWIFTSPRSLGEDAAERAADMFCGGISQDIPIWENKVYRPRPVLRPMEREISEHRRWSRQFYSFPEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T2T8</accession>
    <name>A0A1H5T2T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57110">
        <property type="protein sequence ID" value="SEF57110"/>
        <property type="gene ID" value="SAMN04489712_101460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF57110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="29461" checksum="722FC2D0C2743866" modified="2017-01-18" version="1">MDNRSLKDRRVLVAGASAGIGRALAVHAVRDGARVLLAARRRDRLEQACREAGGGDPVVADLCRPQDCDRLAAQAGERLGEIDVLVCCIGIAPLRMLADTTGEDWVRVLETNVVGVHRLLRACLPVLAPGGMVMVLSSESIGQPRTGLGAYATSKAALERLVEGWRTERPGVRFTTVRVGATFPTDFGNDFEPRLLERVLDDWSARGLAQRDFMAPGEVAEVLAGVIAASAGHPGIGLDHLTLRSPSPVVGTFDDALGLPSADSAPPADAATPEQGAVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T4B9</accession>
    <name>A0A1H5T4B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57752">
        <property type="protein sequence ID" value="SEF57752"/>
        <property type="gene ID" value="SAMN04489712_101482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009284679" evidence="1">
        <location>
            <begin position="36"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF57752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="31257" checksum="6B8A5D17DA45AFFF" modified="2017-01-18" version="1">MRAPLKRLRRWLVALPAAAVLAVGVTAAPNSYATADSSYQRGPAPTEASVRADRGPFQVARVNVPGAGFGSGTIYYPTDTSQGTFGGVAVSPGFLSPEILIAWLGPRLASHGFVVITFTTNTPTDQPDSRGSQLLAALDYLTTQSPTAVRQRLDNTRLSVIGHSMGGGGALRAANDRPDLQAAVPLGPYHTTKDWSGVRVPTMIIGGQYDSIAPNDQHSERFYNSLDSAPEKAYLRVTGTTHITVGTGTPGVGKYVLSWLKRFVDDDTRYDQFLCPTPSGPDVVEYHSTCPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T7Y5</accession>
    <name>A0A1H5T7Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58952">
        <property type="protein sequence ID" value="SEF58952"/>
        <property type="gene ID" value="SAMN04489712_101519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="128"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF58952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="223" mass="24081" checksum="CE948EE0B99EFE52" modified="2017-01-18" version="1">MTESPAQTPAGHPVLAGREHESAALADVVRRLVELTVTTTAPAATTREAVRRLEAVADILERHVPDPPLPKTILSEPVDNAAGLAARMPFDNVIGRHNPLALPLDLEFDPPRALLRGAFTRAYEGPPGCVHGAVLAASFDIVCAAANIVAGLPGPTARLEITYRRPTALYEPCLFEGQVEAQDGRRIRTVGRLLQRDRVTVEAVGDFVLLDHAQIARMSERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U3Q7</accession>
    <name>A0A1H5U3Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kynurenine formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69048">
        <property type="protein sequence ID" value="SEF69048"/>
        <property type="gene ID" value="SAMN04489712_101838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF69048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28175" checksum="CAB677B2F57E263B" modified="2017-01-18" version="1">MSLWQHLDGAKVVDLAQPMRTGMPQSPNHPRFRMVIERRHGDMVREDGGSAANEVILTGGHVGTHVDALGHVSQDGYVYGGVEAAGIQSNQGLSQHGIDAFPPYVGRGVLLDVTAVHGVDVLPPGYEVTPDDLQAAQVKADVEIRPGDSVLIGTGWSRNWDKPSLFVGDEGGVPGPGPDAARWLVDRGVRVAGGETIAFERIAPGRGHATLPVHRILLVEAGVHIVETMRLSELLSTGHAEFMLVLNPLPVVGATGAPVRPLAVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V8D4</accession>
    <name>A0A1H5V8D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83021">
        <property type="protein sequence ID" value="SEF83021"/>
        <property type="gene ID" value="SAMN04489712_102192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF83021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="32651" checksum="002F93D228238440" modified="2017-01-18" version="1">MLIANPKATSTSRRVRDLLVRAFSGDLDLELAETAHRGHATELARRAAEDKYDVVLALGGDGTVNEAINGLLAGGPAPTLPALAVLPIGSTNVFARALGLPGEPIGATRLVLDALRAGRHRWVGLGLADDRYFTFCAGVGLDAEVIREVEERRDAGARSNPLLYVRTALHRFFAGTDRRSPALTVERPGHPPIEGVFLSFVLNTAPWTYIAGHPVNPSPRAHFGAGLDLFGIRSLGVAPVLAAVAGMLLPNGRPVTGPHVVNVHDASEITLRADRPMAFQLDGDYLGERRQVTFRSVPRAIRIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VCG6</accession>
    <name>A0A1H5VCG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85009">
        <property type="protein sequence ID" value="SEF85009"/>
        <property type="gene ID" value="SAMN04489712_102263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF85009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="309" mass="31745" checksum="67F455342F78051F" modified="2017-01-18" version="1">MPRTCVVALDVGGTRIKAGLVDVEHRVLADQVHDTGRQDGPEAVVERVLDVLDELAGQARDQGLTPVAAGVVLPGIVDEAAGRVVFSANIGWRDLPLAGQLAERTGLPAAVGHDVRAGGLAESVLGAGRDQRDLLFLPIGTGIAGAMIMDGRPYAGGGYAGEIGHTRVDPDGPPCPCGGAGCLESYAAASSIGRRYSELHGGGERVSAAEVAERVAAGEPQAVAIWQDAVEALATALHTYVTICAPRLVVVGGGLSESGELLLAPLREALAARLTFQRVPRIVRAALGDRAGLLGAALLAWRAAEDHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VZI3</accession>
    <name>A0A1H5VZI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92682">
        <property type="protein sequence ID" value="SEF92682"/>
        <property type="gene ID" value="SAMN04489712_102533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF92682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="29889" checksum="E0BB1E5C43C32087" modified="2017-01-18" version="1">MNRADLAIVISLISTSITATGVAWQLVLYRLSGARLQVRLIPAAIDIHETVVSGPDKGWSDLPLRGLQKWKVDVSKIQVTNIGRTAVSVSAMSLDIKGVYPFRRGRFTISGLPVPVRGGNKDEVIRLEAGATANMYFDFWPLIEEAKKRQADNGKSGAIYIRGSVLPAGRRACRSSWRKRWKILPEQRVLRRDETVTRELNAYRTLWSHLHRDPEKFGLVGAAWYSLIPELKGEISLAKVKEHLEPLLGPTHHIIAHDVYSALSEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W0E7</accession>
    <name>A0A1H5W0E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent oxidoreductase, nitroreductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92950">
        <property type="protein sequence ID" value="SEF92950"/>
        <property type="gene ID" value="SAMN04489712_102542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF92950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="16658" checksum="618A37F4FA8EFDAB" modified="2017-01-18" version="1">MTAGSRYVEAGRSAAVFNKIAGWLTKHGISLFGSRMLYVRGRKSGQWRGNPVNPLTMDDARYLVAPRGHTHWVRNLRAADGKGELRLGRRVEPFTATEVADADKPAILRAYLKRWKWEVGAFFEGVDADASDEELLRIAPGYPVFRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W4X5</accession>
    <name>A0A1H5W4X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94542">
        <property type="protein sequence ID" value="SEF94542"/>
        <property type="gene ID" value="SAMN04489712_102590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF94542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="581" mass="60666" checksum="95E57BCCF693B425" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WD16</accession>
    <name>A0A1H5WD16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97479">
        <property type="protein sequence ID" value="SEF97479"/>
        <property type="gene ID" value="SAMN04489712_102679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="197"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF97479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="380" mass="40528" checksum="D0B9594F19F587B7" modified="2017-01-18" version="1">MAPRILVDATAVPADRGALGRYVDGLLGALHELGADLVVACQRSDEARYGALAPRARIVAGPVTLVHRSARLAWEQNGLPLVARQTGADVIHQPYYMVPLQAGCPTVVTVHDVTHFSEPEEHDPVRSGYLRSATRTAARRATRLIVPSNATRDELVRLLAADPARIDVAYHGVDHRVFRPPAADEVKRVSDRLGLHGHPYIAYLGALEPRKNVPNLIRGWVRAVAEMHEPPALVLAGGPGGWDDEVDAALATVPVHLRVIRPGYLSQASLPGLLGGALAVTLPSRGEGFGLPVLEAMACGAPVLTTRRSSLPEVGGDAVAYTEPDADAIAAALRELISDPGRRTALAEAAVRRSERFSWTVSAEAHLRSYRHAAGLLAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WXF5</accession>
    <name>A0A1H5WXF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04172">
        <property type="protein sequence ID" value="SEG04172"/>
        <property type="gene ID" value="SAMN04489712_1034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023866">
        <property type="entry name" value="SbnB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03944">
        <property type="entry name" value="dehyd_SbnB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG04172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="341" mass="37067" checksum="BC67D9AD115CEEC8" modified="2017-01-18" version="1">MSQSPSFAVISGAQVHRAVSGREEQITRIVEAAYRLHGEGRTVNPDSYFLRFPDRPSSRIIALPASVGGEVDVHGIKWISSFPENVAAGIPRASAVLILNDTATGYPFACLESSIISAARTAASAALAAVELSARRGVRPTRVGFFGVGLIARYLHTYLAGNGLEFESLGVHDLSAEHAEGFKGYLERTERGQITVHDKPEDLIRSSDLVVFATVAGEPHVLDPAWFAHNPLVLHVSLRDLSPEIILSSYNVVDDVEHCLKANTSPHLAEQRVGHRDFVAGTLYDVLTDKITPPADQPVIFSPFGLGVLDLAVARHVYDQVQANGDLQTVPEFFHEMKRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XE43</accession>
    <name>A0A1H5XE43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09700">
        <property type="protein sequence ID" value="SEG09700"/>
        <property type="gene ID" value="SAMN04489712_103202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG09700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="32885" checksum="A54D8EEEFEF1029F" modified="2017-01-18" version="1">MRPTVMSSVKSARSLPGALLVAFLVAPILAGCGGGSLDSASTAQEPAQPQRGAPAAGARDGAGEAAGDGENAAGAPGRLTEQAKPGRPAEQVKLNPAGARAVVYTATLRVRAPNVDRASAQAKQLVTAAGGYVQSESAAAADSADLTFKIPSDRYTATLDQLAGRLGTRMSLTQQAEDVTEEVADVESRVRSAEAALDSFRKLLDRANTVGEVINVEQEIARRQAELESLQARQKSLAHQTGYATVTLELRGPDKGEGAGGDDERGGFLGGLERGWNGLVAIGSGLAVATGTLLPFLAVAAAIGLVVLGVRRLVRARRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XM30</accession>
    <name>A0A1H5XM30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12844">
        <property type="protein sequence ID" value="SEG12844"/>
        <property type="gene ID" value="SAMN04489712_103318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG12844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="99" mass="10476" checksum="4E7BF7313287F486" modified="2017-01-18" version="1">MSAGNGSVSYGALPEQLRSVAGPATGPLRGQCATALQHLYGWLQVAVPQQPQLATAIPPLVQAVQLYRAGLDDACAAQLQWVIAQLHQTRVLRPTLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XPD7</accession>
    <name>A0A1H5XPD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Muramoyltetrapeptide carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13230">
        <property type="protein sequence ID" value="SEG13230"/>
        <property type="gene ID" value="SAMN04489712_103332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="169"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG13230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="30681" checksum="1D4F7C5E2F912873" modified="2017-01-18" version="1">MRLAPGDLVTVIAPSGPVGAAALRRGVAILEGWGLRVRVAPHTEAASGYLAGPDTARAADFTEAWTDPEVRGVLCARGGYGAQRMLDLIDWERVREAGPKIFLGSSDVTALHGALARHLGLVTYFGPMPAGLALSRDRATAEALHRALFTGTDALTAPKGEALFPGIARGRLHGGTITLLATSLGAQEGAPPAGDRVVFLEDVTESPYRLDRSLTQLLRAGWFAGVTGVVLGSFVDCGPEEELRAMLRDRLGPLDVPVLWGFPAGHGPTQLTLPFGMWAELSADTATLRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XXF3</accession>
    <name>A0A1H5XXF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16454">
        <property type="protein sequence ID" value="SEG16454"/>
        <property type="gene ID" value="SAMN04489712_103458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG16454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="513" mass="56796" checksum="8A063A47D6130613" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZW2</accession>
    <name>A0A1H5XZW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16967">
        <property type="protein sequence ID" value="SEG16967"/>
        <property type="gene ID" value="SAMN04489712_103479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="432"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG16967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="514" mass="56685" checksum="8F3F0BBEFED7529B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y0P7</accession>
    <name>A0A1H5Y0P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mce-associated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17531">
        <property type="protein sequence ID" value="SEG17531"/>
        <property type="gene ID" value="SAMN04489712_103500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="186" mass="19939" checksum="64A10F41A4994868" modified="2017-01-18" version="1">MASITARLSRTSDPLRTTALTLLVIAALCAAWFGWSWYGAAHDDALGYSRTREEVLRAGEQAVQNMNTLDHRDLAGGLKAWQDSSTGELNRQITAGQAQFEQQVRQARTITTAKVLESALTELDVRSGKAAIMVALQITVTPPDGKPTTKQSRMLGQLTRTDTGWKLSALGQAPVGGSAPSTETGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YVY0</accession>
    <name>A0A1H5YVY0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="15" type="ORF">SAMN04489712_104214</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28261">
        <property type="protein sequence ID" value="SEG28261"/>
        <property type="gene ID" value="SAMN04489712_104214"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5014002841" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014002842" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEG28261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="14840" checksum="4ACA57047D1A6E4A" modified="2017-01-18" version="1">MFRTMFKSKIHRATVTQADLHYVGSITIDADLLDAADLLPGEQVHVVDIDNGARLETYVIAGPRGSGVIGINGAAAHLVSPGDLVIIISYAAMSEEEVRSFEPRVVHVDRANRIVSLGSDPAEPVPGSDQRRGDELPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXC8</accession>
    <name>A0A1H5YXC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28684">
        <property type="protein sequence ID" value="SEG28684"/>
        <property type="gene ID" value="SAMN04489712_104233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012022">
        <property type="entry name" value="UCP005295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42658">
        <property type="entry name" value="PTHR42658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005295">
        <property type="entry name" value="UCP005295_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG28684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="281" mass="31336" checksum="6D79B132277FB1A5" modified="2017-01-18" version="1">MRIFDPHIHMSSRTTDDYERMYEAGVRAVVEPAFWLGQPRTSPDTFADYFDSLLGWEPYRASQFGIRHHCTIALNPKEANDPRCRGVLDLLPRYLAKDGVVAVGEVGYDSMTPEEDEVFAAQLALAIEADLPAMVHTPHRDKATGTRRSLDVVRESGLASERVLIDHLNELTVAMVKEAGCWMGFSVYPDTKMDEDRMVTILKEYGTERVLVNSAADWGRSDPLKTRKVGEAMLKAGFTAEDVDTVLWDNPVAFYGQSGRLDLAEADPAEFYAGNTIKRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z427</accession>
    <name>A0A1H5Z427_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">SAMN04489712_104338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31091">
        <property type="protein sequence ID" value="SEG31091"/>
        <property type="gene ID" value="SAMN04489712_104338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="13"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG31091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="26515" checksum="5B77FA6B50FE1A84" modified="2017-01-18" version="1">MVSYKSPRELSVMREAGRVVAVTLERVAAAAEPGMTLAELDAIAARCIKEHGAQPSFLHYLPRSAPTPYPAVTCLSVNEVVVHGIPDGRKLRQGDLLSIDCGAEVGGYHGDAAVTISIGPPDAAAARLLKVTERALKRAIEAAQPGARLGDVSHAVETVGREAGYGILEGCGGHGIGTAMHEDPSVPNTGRPGRGLRLREGLTIAIEPMFHEGGDDGGFVLRDGWSIVTADGSRAAHFEHSVAVTADGPVILTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZA89</accession>
    <name>A0A1H5ZA89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="9" type="ORF">SAMN04489712_104401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067832642.1">
        <property type="nucleotide sequence ID" value="NZ_FNVO01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32266">
        <property type="protein sequence ID" value="SEG32266"/>
        <property type="gene ID" value="SAMN04489712_104401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG32266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="13756" checksum="DC9D6435D4AF17A1" modified="2017-01-18" version="1">MPTIQQLVRKGRQDKVTKNKTPALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSGIEVTAYIPGVGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGSLDTQGVRNRKQARSRYGAKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZAH3</accession>
    <name>A0A1H5ZAH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33533">
        <property type="protein sequence ID" value="SEG33533"/>
        <property type="gene ID" value="SAMN04489712_104459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG33533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="6777" checksum="A6C0019089A9DF45" modified="2017-01-18" version="1">MFAQPPTWRKSTHCGPNAGCVETARLAAYVGVRDGKQPGGPVLRVSPDGWRTLLTRIKTDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A058</accession>
    <name>A0A1H6A058_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41327">
        <property type="protein sequence ID" value="SEG41327"/>
        <property type="gene ID" value="SAMN04489712_10574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG41327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="607" mass="67445" checksum="ED3D6B30EBE01FB4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1M3</accession>
    <name>A0A1H6A1M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase AhpD family core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41945">
        <property type="protein sequence ID" value="SEG41945"/>
        <property type="gene ID" value="SAMN04489712_105108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG41945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="194" mass="21813" checksum="BFA42183CF98E750" modified="2017-01-18" version="1">MTRISLNPPRTLWYRMGEWFVRRQYGAALDPVRAMGHHRGVGTAYAMFELQVPRWRKVDRTLKDLAVMAAAVKIGCSWCVDFGTWESHMHGIPLEKVQAVPHWRDSDLFSPVERLVMEYAEAMTEDPPGVTDELVEALRRHGFDDAGLVELTMIVAVENLRSRFNAAAGLTGQGFKDRCEIPAGAGKESGERGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1Z8</accession>
    <name>A0A1H6A1Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42759">
        <property type="protein sequence ID" value="SEG42759"/>
        <property type="gene ID" value="SAMN04489712_105158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292222" evidence="2">
        <location>
            <begin position="44"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG42759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="25404" checksum="FBE7EB2EF8808A06" modified="2017-01-18" version="1">MLTPTPSGLRPTRLSALSAATIVLAGSLTVLNGVFLNESPALADPCGGGGQNFGCGLEDGGGGSGGGGGGNGGGGGGGTGEIPDVNQDGGAGGPGAPNNPAQPAPEPATLDLAAQARSTAELPTPTAHTAPSDKTYVSLRTRLWVDGFVPVSTEPINVGNQIVVATATPRTVTWSLGETTVTCNGPGSKTSDACSHVFQRSSASTPGGAHQVTATITFSVTWTCVGSGCDAPGGTLDDLTSTSIPQPLVVSEIQTNSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2U7</accession>
    <name>A0A1H6A2U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42682">
        <property type="protein sequence ID" value="SEG42682"/>
        <property type="gene ID" value="SAMN04489712_105153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG42682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="24685" checksum="0669C8B6B03FE3B9" modified="2017-01-18" version="1">MDGTLRLYDPGNGRLEELPPGPLHIHVRGPGLRAFVIADLLRRVAGRRRRRVRVTCSGPFPEVRALADFNVLEMEAGETASAQVVVAEGDESNAIQPNTARLLLVPAFEPPPADEDPMTLRLAILHTAYRDPLPWSERLADARARLDRWRALMAEWAESPGRPMDRTYAADAERALTDDLDSPAALAVLEGLAADPAVAPGAKFETFVHLDLVLALDLVRDIGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2Z0</accession>
    <name>A0A1H6A2Z0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_105132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42337">
        <property type="protein sequence ID" value="SEG42337"/>
        <property type="gene ID" value="SAMN04489712_105132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.166.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023180">
        <property type="entry name" value="THP_succinylTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037133">
        <property type="entry name" value="THP_succinylTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14805">
        <property type="entry name" value="THDPS_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_N_2" evidence="5">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG42337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="29713" checksum="0F0F3CC59C249E9A" modified="2017-01-18" version="1">MTDTFTSPIPGLIDELWERRDQLSPDDADARAAIVAAVDQIDTGQARVAFVDPATDEVVVDERAKRAILLSFKVLGMVRAQVGDFHHHDRIPLKTRLDGVRVVPGAIARWGAYLAPGVVLMPSFTNIGAYVDSGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPPNAVPVVVEDDAFVGSRCMVVDGARVRRGAKLGAGAILTKTTRVYDVETGEELPRGEAPAWSVCVSGTRPKKFPGGEFGMQCLLVLKRLEEGQQHDKLALNEILREHGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A392</accession>
    <name>A0A1H6A392_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_105138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42437">
        <property type="protein sequence ID" value="SEG42437"/>
        <property type="gene ID" value="SAMN04489712_105138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="13"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG42437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="257" mass="27139" checksum="F806AA4D63DF1331" modified="2017-01-18" version="1">MSTLTLALRDSATMVRRQLKRLLRYPSMTVQLVVTPVIILVLFVYVFGGTLGAGLGGGRDVYVDYVVPGILLMAAATAATGTAVMVATDMTEGIIARFRTMRISRASVLTGHVVGSVIQQLLGMAVVIGVALAIGFRPNATPVEWLAATGLLTLLVVAVTWLAVALGMKSPTPEAASNAPMPLVFLPFLGSGFVPTDSMPAVLRWFAEYQPFTPIMETVRGLLLGTPIGNSAAIATAWCTGIATASYLWAKHTFDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABX9</accession>
    <name>A0A1H6ABX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SAMN04489712_105335</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45971">
        <property type="protein sequence ID" value="SEG45971"/>
        <property type="gene ID" value="SAMN04489712_105335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292526" description="Aminopeptidase N" evidence="11">
        <location>
            <begin position="29"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="56"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="323"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG45971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="474" mass="51448" checksum="90BEC9254AA3A88B" modified="2017-01-18" version="1">MRTAPRALATVALTVAAGLVVSAVPAHAAPRFTPGAPGAGDPYFPDMGNGGYDVAHYDVSLRYTPANKGIKATTRVQAKATQHLSRFNLDFLGPLKVHSVTVNGKAAAFRRTGAQELVITPKQGLRKGKRFTVAVSYSGVPQRIDDETLGTSGWVATDDGAVALNQPFGTATWMPVNDTPRDKASYSFALTVPKDLQALSNGDFAGRKTSGGLTTWRWEMPRPMASELAMVAIGRYNLTWGRTPKGVPNITAIDSKLDTAVDQGKNFHKLTADITDWGSKLFGKYPFGSTGGIVDAIGVGYALETQGRPVYDRINRPGVNPSASLVAHEIGHQWFGNSVTPEQWKDIWLNEGFATYTEWLQSEQSGGDTAQQIFDEVYATPAGDALWQVKVADPGRDDIYAHAVYDRGAMTLHAVRQTVGDKKFFQLLSTWYARNRDGNVTTADFVAHAKKYGDAKRLDALFNKWIHTTGKPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADA9</accession>
    <name>A0A1H6ADA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NitT/TauT family transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_105360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46362">
        <property type="protein sequence ID" value="SEG46362"/>
        <property type="gene ID" value="SAMN04489712_105360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG46362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="28795" checksum="B997ABBA440E3E71" modified="2017-01-18" version="1">MSQATTATPSRTAAAVRLSGVSKAFGSGDTALLALDNVSLEVSPGEFVCLLGASGCGKSTLLNLVADLDKVTAGSIDVGGARVALMFQEPALFPWLTVTGNLELALRQRGVPRQERRARAAELLASVHLSGFEKKRPHQLSGGMRQRVALARALALTVDEDGDGGRGTVLLMDEPFGALDAMTRDLLHDEIERIWRERGLTVLFVTHNVREAVRLGDRVVLLSSRPGRVVEEFAVPMERPRRIDSTEVATLAATITDRLRAEVGRHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AFA6</accession>
    <name>A0A1H6AFA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, DHA2 family, multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_105406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47181">
        <property type="protein sequence ID" value="SEG47181"/>
        <property type="gene ID" value="SAMN04489712_105406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG47181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="503" mass="50864" checksum="DC1551AB76D88B48" modified="2017-01-18" version="1">MTTSTRTGARAPGETRAGRREWAGLGVLALPALLASLELTVTHLALPSIGRDLGANSTQLLWIVDIYAFLLAGSLLTMGALGDRIGRRRLLLLGAAGYGVASVLAAYAPSATMLIAARALMGVAGATLMPSILALVAVMFTDPRQRTTAIGIVVAAVSGGTAIGPLAGGWLLERLWWGSAFLLGVPVMALLLVIGPILLPERRAPGPGRLDLTGVLLSLAAVLPVVYGLKRIAAEGAAPGSAAAVLVGLVMAGIFVRRQRRLADPLVDLRLFADRAFAVAVVTLFLGIFVLWGSNYAIAQYLQLVRGLSPLEAGLWTAPSAVGVIAGSMLAPRIVRRVGPGRVIGAGLVISAIGYGVLAGVEVAGGLVVLVAGSVVVSAGLGPMMALATDIVVGSAPPERAGAASAISSTAPQLGGALGIAVLGSVITAVYRDRMAAAVPAARDNLTAAVAATADLPAPAGARLLETARAAFTQGFQLTAAISAALMIVIAVAVIAFLRDPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AH31</accession>
    <name>A0A1H6AH31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48073">
        <property type="protein sequence ID" value="SEG48073"/>
        <property type="gene ID" value="SAMN04489712_105455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG48073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="35923" checksum="5FED581B4E9A999F" modified="2017-01-18" version="1">MGSGQMVAVFGAYGHTGRFVVAELLRRGFVPVLSGRDADKLQALAASHPGLRTQVASADDPVALDRALADTAAVINCAGPFATTAAPVIEAALRAGIPYVDVAAEIEANADTFAHFTDRARAAGAVIVPAMAFFGGLGDLLATAAMGDWTAADEAHIAYGLSSWHPTDGTRASGKVSRDRRNGGRVRYANGRLEYRADAPPTLKWSFPDPMGTREVIGEFTMADVVTIPSHLSVPEVCTYMTVEAARDLAAPDTPAPAAADEHGRSAQTFLVDVVVRSGGTERRATASGQDIYAVTAPLVVEAVDRILTGRTRTVGVASAGEMFDAPDFLRALSPHISLDPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYL2</accession>
    <name>A0A1H6AYL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53713">
        <property type="protein sequence ID" value="SEG53713"/>
        <property type="gene ID" value="SAMN04489712_106111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="191" mass="19284" checksum="B070D677DFE10B21" modified="2017-01-18" version="1">MDAALLAHPGEENGAAASDGGGRTAAVPEEEDPMRSAGLLVGLSATALVAFMATPAHAAPGKVDGSVTAAGTTCSWTNADTTNTPPNTLTINHTTVSPTCTSALITVTLSASPTVTFNDTPPGTATSPQVNVVATAPIVGTCNYRVNNVTVNRQGTTRTYTRTTPLTATKTGGGILCPASQAIDSVRFTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B0R5</accession>
    <name>A0A1H6B0R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type glycerol-3-phosphate transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54421">
        <property type="protein sequence ID" value="SEG54421"/>
        <property type="gene ID" value="SAMN04489712_106156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293318" evidence="1">
        <location>
            <begin position="34"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG54421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="449" mass="47746" checksum="64B0504A38C8E66A" modified="2017-01-18" version="1">MSQPLFRPGTSRRTVLRGALGLGALAAAGPLLAACGGEAGEALDPTGRPDLDGVTLKVLVNQPNAGAFEILRKSFKAETGADLQITPVAYDKLLAKSVLDVQSGAGQFDVIMYWYVGLGTLAAGGVLEDLTAYIKANPDIDTGDLLPSIYDPYTLYEGKRWGLPFDGDTHILYYNTELFERYTLEAPRTWEDSNAAAEKITKDSRGEHYGVIIEGQQVPIILGCTFANRLVGFGGRFLDEAGKPVLASDEAVAALQSVLDAAPHALPTPLQTGFDQALPAFLSGKAAQLEFWTDHSVKAQDPEHSQVVDKWDVVTLPVGGSNTKPATSLDAGFALGVSTLSKRKEAAAAFVKFAASKKQNEAQIADPTSGSDPIRTSTLSAPVFKKSFGRAADVVAEGLSGSPLVWPNGPKAPELLQVLVDELALAFQGKQQARQTLEKVHSAWEKELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B280</accession>
    <name>A0A1H6B280_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54983">
        <property type="protein sequence ID" value="SEG54983"/>
        <property type="gene ID" value="SAMN04489712_106194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG54983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="295" mass="30724" checksum="B7E9AD73C57CFC9D" modified="2017-01-18" version="1">MLHTTVVEVGPRDGLQNESVILPAADKVELIRRSVEAGVRRIEAVSFVNPKRVPQMADAEEVMAAVPRTPEVSYIGLVLNRRGLDRALAAAVDEVNVVVVATDTFCVRNQGCTTDEALAAWDDIARAAADAGVPASMTIAAAFGCPFEGTTPPSRVAEIARRAHAAGAAEIALADTIGVGVPRQVRELTRLVRRAAPGTPLRFHFHNTRNTGYANALAAVEEGVHVLDASTGGFGGCPFAPAATGNIATEDLLYALHHSGLTTGVSLEAVAATGAWLGERLGKPAPALLGRAGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B436</accession>
    <name>A0A1H6B436_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55294">
        <property type="protein sequence ID" value="SEG55294"/>
        <property type="gene ID" value="SAMN04489712_106220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG55294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="16971" checksum="270DA5A036A06AD6" modified="2017-01-18" version="1">MRVYLGSDHAGFELKQHLIGWLTDNGHDPVDCGPQVYDAVDDYPPFVLRAAERTAADSGSFGIVLGGSGNGEAIAANKVKGIRAALVWSEEIAILAREHNDANVISIGARQHDTAAAIRFVEIFLNTPYSKEERHTRRIDMLTEYEDTGELPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BEU4</accession>
    <name>A0A1H6BEU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59289">
        <property type="protein sequence ID" value="SEG59289"/>
        <property type="gene ID" value="SAMN04489712_10759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG59289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="26323" checksum="DDDFB9B988A90A83" modified="2017-01-18" version="1">MQGLQDKVILIAGAATGLGAASARRLAQEGAKVVVGDLNLAGAEETAAAINDTGGRAVAVRFDISDDASVRELVSVAVRTYGGLDAVHINAGDMGAVQQDTDVVDIDLAIWDRTIAVNLRGHMLVTRHTVPELLARGGGAIVYTSSIASFTGEPKRPAYAVTKAGINALARHVASRWGRDGVRANAITPGLILTPEIRDGAPPEMLKAMLARTRSPRHGEASDVAGMVAYLLSDEGSWINGQTVNVDGGTVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJ39</accession>
    <name>A0A1H6BJ39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60768">
        <property type="protein sequence ID" value="SEG60768"/>
        <property type="gene ID" value="SAMN04489712_107155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG60768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="38" mass="4147" checksum="6A560A11BFDD85C5" modified="2017-01-18" version="1">MNLLSRMNAFPTLSFRTAAPGEPVTPCQGIRDISAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNG5</accession>
    <name>A0A1H6BNG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61947">
        <property type="protein sequence ID" value="SEG61947"/>
        <property type="gene ID" value="SAMN04489712_107259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG61947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="98" mass="10963" checksum="2D977C30D79CB5EE" modified="2017-01-18" version="1">MTPDSTETATPYDTRLEYLERLGDALVHRGFQVRLSAPLERPASLHVMNPEATALTENILAEQGSDGWWFWWSWAERIAAADDVATAADRVARVLAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUJ2</accession>
    <name>A0A1H6BUJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">23S rRNA (Cytidine1920-2'-O)/16S rRNA (Cytidine1409-2'-O)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64302">
        <property type="protein sequence ID" value="SEG64302"/>
        <property type="gene ID" value="SAMN04489712_10812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG64302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="28523" checksum="7B48701957C05609" modified="2017-01-18" version="1">MAVTRRRLDAELVRRKLARSREQARELIEEGRVRVGGQTAAKAATQVETGAAIVVESAGEEPEYVSRGGHKLAGALTAFDALPVKGRRCLDAGASTGGFTDVLLRAGAAHVIAVDVGYGQLAWSLRTDERVTVLERVNVRDLEPGRLPGEPPTLVVGDLSFISLRLVLGPIQRCAAPDADYVMMVKPQFEVGRERVGAGGVVRDPQLRAEAVRDVAEHAATLGLGVLGVTASPLPGPMGNVEYFLWLRAGAPPLREADLDRAVTEGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BV49</accession>
    <name>A0A1H6BV49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="7" type="ORF">SAMN04489712_10813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64315">
        <property type="protein sequence ID" value="SEG64315"/>
        <property type="gene ID" value="SAMN04489712_10813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="182"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG64315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="32885" checksum="D64F205C3009C071" modified="2017-01-18" version="1">MLVVAHTGRPEAVRSAELVIERLSKAGISVRVLDEEAGDLHCAGVDVLPASAVAAEDAELVMVLGGDGTILRAADLARMSGTPMLGVNLGHVGFLAEAEREDLTATVERVVERHYDVEERMTIDVTVHRNGAVAAATWALNEATVEKAERERMLEVVAEIDGRPLSHWGCDGVVCATPTGSTAYAFSAGGPVVWPEVEAMLVVPISAHSLFARPLVVSPRSVVAVEVLPDTPRAVLWCDGRRTVGLPPGARVEVRRGAVPVKLARLHRTPFTDRLVTKFGLPVTGWRGRARPGSGGEGREHRHPAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYN6</accession>
    <name>A0A1H6BYN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65824">
        <property type="protein sequence ID" value="SEG65824"/>
        <property type="gene ID" value="SAMN04489712_108139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG65824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="25271" checksum="9EF0A855CAD54E11" modified="2017-01-18" version="1">MERVPVTSPFWEALDDAGRATLRRAGRLRTFRPGGEPLTFEGDVSTHVTIIMEGWAKVISPTGSGREVVLAVRGPGDLVGEVSAMFDGPRTATVQALVPIKALNVPAARFRAFLDENPRTWWPLVATIVDRMGELGNRLRVHAGADGTCRLAHLLVHLAELSLRYTEPGPGGRVPILPQLSQADLGSWVDASRETAARGFGELRDKGLVATAYKRVTVLDLPGLRAFADGCAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZK1</accession>
    <name>A0A1H6BZK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66139">
        <property type="protein sequence ID" value="SEG66139"/>
        <property type="gene ID" value="SAMN04489712_108167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG66139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="260" mass="27676" checksum="8512A87D720BDFA1" modified="2017-01-18" version="1">MRNDPFDLTGRRALVAGAAWGGLGAYAALALAGRGAEVVVADLPSRGADLDATLGRLLAAGAKARALRFDVTRQEHVETLVAHAADPDGRLDVLVNAAGVMLRREAFDTSLEEWRRVLDVNLTGTWLLNRAAGRRMVAAGRGAIVNFSTVYAERVGPIPESAYYASKAGIANLTRSLAAEFGPHGVTVNCLAPAVFYPTEMTAPLRDDPERLAWFEARTMLGRLGEPGADLDGPLLLLASDAGRYMTGQVVYVDGGWSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1S5</accession>
    <name>A0A1H6C1S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation-control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66960">
        <property type="protein sequence ID" value="SEG66960"/>
        <property type="gene ID" value="SAMN04489712_108241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009776">
        <property type="entry name" value="Spore_0_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40053">
        <property type="entry name" value="PTHR40053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07070">
        <property type="entry name" value="Spo0M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="398" mass="42614" checksum="6627397F0CE534A5" modified="2017-01-18" version="1">MVFRQLLGAFGVGGPSVETVLASSHCRPGEYLAGEVRVQGGDRDAYLDQVVLSLVTEVEVEHDDQEGAGVLEFHRGAITGGFVIGAGQFHSIPFQLPIPWELPITEVHGRHLHGMAMGVRTELEVAGQLDKGDLDPVAVVPLPSQQRVLDAFAELGFGFKSADVEHGHIAGLHQELPFYQEIEFYAPPQYSGHIEEVELTFVASPHGLAVVLEADRRADLFSEGGDSFGRFQVSHEQALYMAWEHELTGWLQAVVGHLSGGHAVHGHHDPYGSYGHHHDPHGHQGGHGGPGWGGVAAGAVGGAAVGFAAGAVVNEMLDDDSDEDEAAEEAAEEAAEAVQAAAYQAAIEDAIEEAVEEAVEEAYEDAIEEAVEEAVEEAYEEAYEDAYEEAVESFEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDN2</accession>
    <name>A0A1H6CDN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fur family transcriptional regulator, ferric uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71064">
        <property type="protein sequence ID" value="SEG71064"/>
        <property type="gene ID" value="SAMN04489712_109237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG71064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="16270" checksum="CA85E3894A8EB0FF" modified="2017-01-18" version="1">MSPVTAHPTTPPEPPTPAEALRGAGLRVTAARVAILEAVRSGDHLVAETVAERVRQRVGTVSTQAVYEALHALTGAGLVRRIEPAGSPARYEGRIGDNHHHLVCRRCGAVTDVDCAVGQAPCLEPASDAGYRIDEAEVIYWGLCPGCQRETAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJJ4</accession>
    <name>A0A1H6CJJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73100">
        <property type="protein sequence ID" value="SEG73100"/>
        <property type="gene ID" value="SAMN04489712_11071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="424" mass="48091" checksum="2EAA04C44B44E039" modified="2017-01-18" version="1">MTDTRHRLDVFDPYLYARGTPHETYRRLRDEHPVHWQEEYEVGGWPAGPGFWAVTRYADVVHVLRTHTEYSSWAGATQIRDPDPADLPFIRQMMLNLDPPDHVRLRRLVSRAFTPRRVERFAAQVRARARRLVDDIAERGECDLPVDVTDDFPIQNLADLIGIPPEDRDPILEWTNRVIGYQDPEHAEVVRGPDGAPVDPRSPAALADMFEYAHRLAERKRREPADDVMTALAIAGPDGHGLGDAELSMFFFLLVIAGNDTVRSALPGGLMALLDHPDQHRRLLADPTLLDPAIEEMLRWHPPVLSFRRTAVRDTVLAGQPIAAGDKVVVFHGSANRDERRFPDPMRFDIARVPNEHVSFGDGPHVCLGAHFARLQLRAFYRELLWRLPDIEYAGPPTRLVSNFIAGIKHLPVRYTPAPRLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLM1</accession>
    <name>A0A1H6CLM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73818">
        <property type="protein sequence ID" value="SEG73818"/>
        <property type="gene ID" value="SAMN04489712_110158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG73818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="31731" checksum="5F1A96B03C9C4E81" modified="2017-01-18" version="1">MMGVAKVIRRGRSRRAQDEHEALQGAGWLFREVVGHGGTLPDLDAGRHDVRVLARAGALRGMGVQMVADGRVRATWRVVKRYDRHPVMLACEPATPPSPRMLTRCTWRFVVYCEAAALTRHRDRLALDWRPAGGVPEERLSGTVDRPVRGDRDGRVTIVSTGDEVRLPSAEGRGLLADTMVRCTVTRDVDTGGLIAVTVVPEDESESVRPLVDGWTPRSGDDRFTAHDRRRALPVRSTALGAPEAADRAGRLGRWLWDGENGFFERATAFIGVLAGFLALIDAVRSVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNU4</accession>
    <name>A0A1H6CNU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3HB-oligomer hydrolase (3HBOH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_110194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74156">
        <property type="protein sequence ID" value="SEG74156"/>
        <property type="gene ID" value="SAMN04489712_110194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047989">
        <property type="term" value="F:hydroxybutyrate-dimer hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019605">
        <property type="term" value="P:butyrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016582">
        <property type="entry name" value="OHBut_olig_hydro_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10605">
        <property type="entry name" value="3HBOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295041" evidence="6">
        <location>
            <begin position="32"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG74156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="440" mass="47675" checksum="8947213822161910" modified="2017-01-18" version="1">MPTIRRLLTGALLGTVVAAPLVAAPAGPASAGSCPEVTVPGAEHQVTACLDDLTTAGTVASGHTVPADYAGLHPAGARNPSGVPGVQIDGYFPDDSTFNTNHGWNHDSQFVIRLPQRWNGGLVVAGTPGNRRQYANDFTISDAVLAQGYAYAATDKGNSGLQFYRDGKRPGDAIAEWNHRVTQLTKAAKKAVKHRYGRAPGRTYVAGTSNGGYLVRWQLENHPELYTGGVDWEGTLWREDGPNLLTFLPPVLAGRPDKTYPAGSSFLWPYHEQVYWDLTQRIYREELDPGYDGATEAGTPYCAPGTPACDADYDYASRPREVRKAVRKISLTGRIGRPMVTLHGTLDALLPIDQDSDVYAAMVRRQGRGTLHRYYRIEGGNHTDGLYDAFPDRLRPLLPCYRSAFTALEAWTTRGVRPPASATIPRPATGDLVNTCALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CP04</accession>
    <name>A0A1H6CP04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryl-phospho-beta-D-glucosidase BglC, GH1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_110225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74423">
        <property type="protein sequence ID" value="SEG74423"/>
        <property type="gene ID" value="SAMN04489712_110225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG74423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="476" mass="54440" checksum="E0DF71F9BB1BC9BA" modified="2017-01-18" version="1">MTDDQRFLRVSGDRLVDGSGAVVRLRGVGVGGWLNMENFITGYPATETLMRRAVRDVLGDERYRRFFDRLLTAFFDERDAAFLASLGLNCVRLPFNYRHFEDDLAPFTILEEGFAHLDRVIDACARHGVYSVLDLHAAPGAQNHHWHSDNATHLPAFWEHVHFQDRLVHLWQVIADRYADNPWVAGYNLLNEPADPTGEIIGPFYARLVKAVREVDPRHTLFLDGNTYSTRFDMFGDPWENTVYTCHDYALAGFVYGGDYPGYTEGEWVDRDQLAAKFLERSEYQRRTGTPIWVGEFGPVYTGDPARDAQRYQILRDQLDLYDAHGAGWSLWTYKDVGLQGLVHLDPQSPYARRFGDFQAKKARLGADHWGSTDEGIRQLTEPIHAFMDEEFPGFDPYPFGRRKYTEDLVRHILFAQPLTVEYADLFRGLDDTELDALADSFALPACIRRDQLTAILTDHCKHSGSEDTPARAETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSF5</accession>
    <name>A0A1H6CSF5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_111105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75980">
        <property type="protein sequence ID" value="SEG75980"/>
        <property type="gene ID" value="SAMN04489712_111105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="91"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG75980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="200" mass="22129" checksum="7A9AF2B7C524A6C2" modified="2017-01-18" version="1">MTTYSLPDLPYDYAALEPAITGEILELHHAKHHAAYVKGANDTLEKLAEARDKEQYGGLVGLEKTLAFNLSGHVLHSIFWDNLSPDGGDRPDGELATAIDEHFGSFEAFKAQLTTATATVQGSGWGVLGWEPRGQRLIVQQVYDHHGNVGIGATPLLVFDAWEHAYYLQYRNVRPDYVAKLWDLVNWNDVAARLTAAKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV95</accession>
    <name>A0A1H6CV95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin HHE cation binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76326">
        <property type="protein sequence ID" value="SEG76326"/>
        <property type="gene ID" value="SAMN04489712_111150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="24643" checksum="5FBBE1AC5993D8BE" modified="2017-01-18" version="1">MSDRTYRLDMRMMVAVHNAFRRDLERIARITARTDDDPRRVLRTAAGWEMFKTYLRVHHTSEDDALWPVMRQALADRPDGLALLEAMEAEHAAIDPLLNAVDTALTDRDHGPERLGDLTDALAVTLGEHLGHEESEGLPLIDATLTEQQWQHFGAVHRDRIGTAAPRYLPWVLDDANEEAAAAILARLPESIRTAYRDEWRSAYAGLDLWSAGNEPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D018</accession>
    <name>A0A1H6D018_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78165">
        <property type="protein sequence ID" value="SEG78165"/>
        <property type="gene ID" value="SAMN04489712_11239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="11696" checksum="CFE0BF2471123BF6" modified="2017-01-18" version="1">MGKQFEVDSGQIRRGGSRMQSSAAGMRGRLQDFQARMAGYGEPWGGDDIGFAIGTIYAAASELAFECYTSQIDGIDEFSEGAIVMANNYQKSEDLSGIEVNRVRDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2R7</accession>
    <name>A0A1H6D2R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YbaB/EbfC DNA-binding family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_112200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79334">
        <property type="protein sequence ID" value="SEG79334"/>
        <property type="gene ID" value="SAMN04489712_112200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG79334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="118" mass="13254" checksum="C0B50BD3ADDAAD77" modified="2017-01-18" version="1">MFGPMKAEDLFGSSLRDLQERMGHLEEVQDRIRNLAVTAESEDKLISATVGPGGRLYELKLDPRVRRLETHELAERIVTMVNEATELLQEATAETVQTLMPEGVGEMFTLPGQDREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4A8</accession>
    <name>A0A1H6D4A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">V8-like Glu-specific endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79466">
        <property type="protein sequence ID" value="SEG79466"/>
        <property type="gene ID" value="SAMN04489712_112220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295494" evidence="1">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="88"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG79466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="305" mass="33036" checksum="2F7D808F0757BE7E" modified="2017-01-18" version="1">MRLWVALGSGCGVVAATVGAMAFTGDDEPVAQVRQAADSGVISATAARSVESYWTPERMAKATPVDGRTATSGGVTTTAAARTAQAYGGIPSVGALFFNNGSGDRYCTGAVINSTSQRLVITAAHCIHGGMGRTYYKNVAFVPKYDRGKKPYGIWTARKLFVHRLWANRSDADLDYGFISLHAKDGRLIQQRVGGNPLAIDQGYRNTVNVTGYPKIKFDSRDRPIWCRTGTAKYARYQVRLECNGFYGGVSGSPWLLKYNSKTKKGYINGVIGGYRGGGSVHWVSYTSYFDKDVANLRKYASNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4V7</accession>
    <name>A0A1H6D4V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80084">
        <property type="protein sequence ID" value="SEG80084"/>
        <property type="gene ID" value="SAMN04489712_11310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG80084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="31" mass="3366" checksum="8C34C01A2F8F72CF" modified="2017-01-18" version="1">MIGQRFPLERAADAHAAIESRATVGKTLLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8H5</accession>
    <name>A0A1H6D8H5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_113150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80776">
        <property type="protein sequence ID" value="SEG80776"/>
        <property type="gene ID" value="SAMN04489712_113150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG80776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="665" mass="68565" checksum="CC1EA94B971B5411" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8M9</accession>
    <name>A0A1H6D8M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81700">
        <property type="protein sequence ID" value="SEG81700"/>
        <property type="gene ID" value="SAMN04489712_114122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="26513" checksum="51470A16076CDC6C" modified="2017-01-18" version="1">MATFVLVPGHWLGGWAWREVAGELRAAGHEVFAVTLTGLAERAAEATAEVDLDTHIADLVELIEGRDLREVVLVGHSGANMAVTGAADRVPGRLARVVYLDTAPLPSGMAMLDFQDPDERAEIERQVRELGGGRLIPPPPFDPAADPDNLAGLDEERLAELRKRATPQPYGPAAQPLTRPAEIPDTPKTLIMTTMPVALVEELAAGGNPVFSMMTGPQWSYRELPTGHWPMLSRPVELAALLDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D971</accession>
    <name>A0A1H6D971_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family mycofactocin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81403">
        <property type="protein sequence ID" value="SEG81403"/>
        <property type="gene ID" value="SAMN04489712_11448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="29871" checksum="39C8FA5979D92D14" modified="2017-01-18" version="1">MSGRVEGKVAFITGAARGQGRSHAVRLAQEGADIIAIDVCRQLDGVPIPMSTPEDLDETVAQVEATGRRIVAAQADVRDYDTMKKIVDDGVARLGRLDIVLANAGLAASGNAIDQLDEKLWRDSIDVNLTGAYLTAKAAVPHLIEGGRGGAIVLTSSVGGLKAHPHVGNYVSAKHGIVGLMRTLAVELAQHRIRVNSVHPTQVNTPMLMNEMTYRMFRPDLENPTQEDLAPISQMMHLLPVPWVEAEDISNAVLFLVSDESRYITGVTLPIDAGSMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAK0</accession>
    <name>A0A1H6DAK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDE superfamily endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82270">
        <property type="protein sequence ID" value="SEG82270"/>
        <property type="gene ID" value="SAMN04489712_1151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG82270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="101" mass="10905" checksum="7DCBEFD0F2BA5337" modified="2017-01-18" version="1" fragment="single">LHALPALYPAAAAGLVVLADIGYLGAGIGIRTPRRPHPDIPSPLDADTRTYNRLLRATRALGERAAAELKQRWRALRHVTLSPGRIGAITQAALVLNNAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DB46</accession>
    <name>A0A1H6DB46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_114124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81706">
        <property type="protein sequence ID" value="SEG81706"/>
        <property type="gene ID" value="SAMN04489712_114124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG81706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="228" mass="24546" checksum="0292352589EB1A61" modified="2017-01-18" version="1">MTEVVTEVREATMPRVLLADDHPVYRDGLRMMLESTGLVEVVGTAADGEQAVRLAGRLRPDVVVMDLQMPRLEGTEAIRRIVAARPQTGALALTMHDDDDSVLAAMLAGARGYLVKGADQEEILRAITAVARGEVIFGPALADRISAYFARLAGSGRPADERPFPQLTARERQVLELIAAGLSNGQIAARLSLSPKTVRNNVSNVFGKLQVADRTQAILRAREAGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDZ6</accession>
    <name>A0A1H6DDZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_115115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82963">
        <property type="protein sequence ID" value="SEG82963"/>
        <property type="gene ID" value="SAMN04489712_115115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG82963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="178" mass="18586" checksum="2E945EAA1D2971F3" modified="2017-01-18" version="1">MAAGDTQITIVGNLVEDPNLRFTPSGQAVATFRIASTPRFYDRQSGEWKDGDALFLTCNVWRQAAENVAESLQRGMRVIVQGRLKQRSYETREGEKRTVYEVEVDEVGPSLRNATAKVNKTQRQGGGYGGGQGGGFDQGGGGFGGAPSGGPSGGQGGGAPANDPWATGGGGFSDDPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFS7</accession>
    <name>A0A1H6DFS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phenylpropionate dioxygenase, large terminal subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_116107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83942">
        <property type="protein sequence ID" value="SEG83942"/>
        <property type="gene ID" value="SAMN04489712_116107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="50"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG83942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="385" mass="42848" checksum="F34D714FEF61672B" modified="2017-01-18" version="1">MERELVRRLLDHIEHRTTDLADDVMELPAEVYSPEHHAEEVEVLFRDEPLVFCLSGALPEPRTYLTVDLCGTPILLTRDKEGKVRALLNACRHRGVRVVDGAGEAVRFTCPFHAWTYDITGRLARVPTAGAFAGMGKEDRGLVELPVAEGHGLVVGRLRPGPTPDIDAYLGPGLADELAMFGFADWKPYGEPHVHKVAANWKVTLDTFRENYHFDFLHSKTLATYAHGGVLTFDPFGPHLRNCSALRSIDRLRDLPEEEWGDVGQHFSYQYALFPNTSLTIDSRHIELWQILPVDAAASEVLHTSYFRPDLSEQELAKAAEMAPWICETVVDGEDFWVAGRTEPGIRTGLLGTVVFGRNEPAPQHLHRGFDAALAAARGRSSTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGZ8</accession>
    <name>A0A1H6DGZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-6-phosphate isomerase, cupin superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84441">
        <property type="protein sequence ID" value="SEG84441"/>
        <property type="gene ID" value="SAMN04489712_1174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG84441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="18062" checksum="B4FB7A205FD00329" modified="2017-01-18" version="1">MTAVTNQPTAPVLVRAENAETLQDGATSLITLLADAGATGGALTANKATFRKGSPGAPAHFHTKATEMFLVLDGAMRILVNDEILTLGKGDFLTVPPTVPHAFAPAPGSEAEMLVVFTPGLHRFDYYRLLERVHRGEATVQDIRDSSQQYDNHYFDSPVWSKALAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHG4</accession>
    <name>A0A1H6DHG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_11742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84651">
        <property type="protein sequence ID" value="SEG84651"/>
        <property type="gene ID" value="SAMN04489712_11742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295912" description="Histidine kinase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="263"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG84651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="478" mass="50720" checksum="043403F285872DF3" modified="2017-01-18" version="1">MRGRGTARRLTLRSRLALLTALAVALAVAGCAVATWFLTRAELYRRLDQSLGTAPPRGVGFRPPPAQPVPRRGSPIEEALADCQSGPRGTGETTPFRITLQAVLADGRRCTVPDSAVLVVEPVDVDVAAGRAGEVFHDGRTADGTPMRIHTRADPSRPGVAISVASPLAETEKSLSNLALLLAAVAAVGVLGAASAGLLVARAGLRPVDRLTRAVEHVARTQDLDVRIPVEGADEIARLSRSFNMMNAALAGSRDRQQQLIADAGHELRTPLTSLRTNIDLLMRSEETGRRLPPDTRRRLLASVRAQMRELTDLVGDLLELSRPARPEPSGETVALHEVLARALRRARLRGPGLQLVESVEPWFVHGDAGSLERAVVNLLDNAVKFSPAGGTVRVRLGGGELTVHDEGPGIAPQDLPHVFDRFWRSPSARSLPGSGLGLSIVARVVAESGGRVRLEPAPGGGTVARMFLPGAPVPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHM3</accession>
    <name>A0A1H6DHM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84721">
        <property type="protein sequence ID" value="SEG84721"/>
        <property type="gene ID" value="SAMN04489712_11757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="24170" checksum="9ACF937DF0BDF00A" modified="2017-01-18" version="1">MIRTGLRGPIQVITLDRPDRRNAVDGPMAQALAEAAHTAERDDQVRVIVLAGAGGTFCAGNDLKAMAAGDFPIPTVDGPPPMRVTRTPAAKPVIAAIEGYCFGGGFELALWADLRVASTTAEFGALNLAHGLPCLDAGTVRLPRLVGQGRALDILLTARRVSADQALAYGLITQLVDPGQALEQALTLAEAVARLPLEALNTARRSVLDQWALPEDEAARNEARLALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJ44</accession>
    <name>A0A1H6DJ44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84715">
        <property type="protein sequence ID" value="SEG84715"/>
        <property type="gene ID" value="SAMN04489712_11756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="3">
        <location>
            <begin position="129"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG84715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="325" mass="34516" checksum="43EC21A0E2E485B3" modified="2017-01-18" version="1">MSTTTITTGPLPARAVRTAVRYGYVPAMLLGVNGAAIALTTAGATHGAGKVWLLVLLAAAIAASFAAEHLLPYESDWNRPLGDGRRDAAHTLVNETLILGSLAAIPALAAAVTVADTWPHHWPLWAQVLAAILAADAGITLVHYASHKIGMLWRFHAVHHSVKRFYGLNGLMKHPLHQTIEMTAGITPLLAVGLPVDVASALALAVAAQLLLQHSNADYRIGPAKHVLALNEGHRFHHLKWAGIGDVNFGLFTLIWDHALRTYSYDGARRFTSDDLGMAAKPHYPVRYLAQLAEPFKTSGACTTSPATGTAGTAALEGARSRAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMH6</accession>
    <name>A0A1H6DMH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86438">
        <property type="protein sequence ID" value="SEG86438"/>
        <property type="gene ID" value="SAMN04489712_11984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296030" evidence="5">
        <location>
            <begin position="36"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG86438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="34758" checksum="8FFBAD29A8121DDC" modified="2017-01-18" version="1">MFPFGTPLRAFPVTTLAVAGLLGLTACGSSDGTTATPGGDSGGGDTKVIASLYPVAWLAQKVGGRDVSVTTLTRPGAEPHGLELTPRQIADIGAAKFTIYVKGMQPAVDEAVDQHAKGKSLDAASVVKTLPSPAGADGHDHGEEEHDHGEEEHGHEDEVSYDPHVWLDPNRMATIATALGDKFAATDSAHATGYRERARSVAAELNALDQSYRNGLRACKRDTVVTAHAAFQYMVDRYGLKQISIAGIDPGSEPSPARLAELTKEIKAAGATTVFTETLVSPKVAETLAKESGVSTAVLDPVEGVQEGASDDYISIMRKNLETLRPALECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNJ8</accession>
    <name>A0A1H6DNJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86266">
        <property type="protein sequence ID" value="SEG86266"/>
        <property type="gene ID" value="SAMN04489712_11937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="49" mass="5029" checksum="954F5F65FB4919A1" modified="2017-01-18" version="1">MSSPVAGHRLSILSEGRAERPMPAGNTGGAAAAERFSGPTATGRRVVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNR2</accession>
    <name>A0A1H6DNR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86811">
        <property type="protein sequence ID" value="SEG86811"/>
        <property type="gene ID" value="SAMN04489712_1203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="67"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="28926" checksum="D90B52C526C63F39" modified="2017-01-18" version="1">MRCMHDISARSVAGVEVVPLCDAVGPMGESLRRPLDETFPGSSPELWERLRDEEPGAFGAGGEWVLHFHCFLLRVPAGPTVLVDTGIGGTHSAAAGWAPVPGRLVDALSAAGAAPADVDVVVLTHLHSDHAGGAVAEGQPTFPNARYVLQRQEMDWLLGAPDNPVAEQTLLPLLEAGCLDAVDGRTRLAEAVELFPTPGHTPGHQSVVIDDHRLVVTGDVVLHPVQLADETVTYLYDEDAATAAVTRSALLERIRTRDGLVAAPHLPSPFARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRS4</accession>
    <name>A0A1H6DRS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87920">
        <property type="protein sequence ID" value="SEG87920"/>
        <property type="gene ID" value="SAMN04489712_12136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296143" evidence="2">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="20512" checksum="B655B9BEF05691C0" modified="2017-01-18" version="1">MTGRMIGRVVKGILATGCVLAVAACGGAGGGAGADAGRDDANPVPSPAPAASQRVPLVVLMPTAWSTGIGSDIPGQTFCPDIRRPGRTAPQTTVSCRFVAPRGAVVHLTAKVRERHPTLVGGNESVRLSLCRNGSWSAPTKTATCTVTMTTGTVLCLDENLFGSAVECPWVEQGYARLPATVPPGFTPGPHTAASPDEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT28</accession>
    <name>A0A1H6DT28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88184">
        <property type="protein sequence ID" value="SEG88184"/>
        <property type="gene ID" value="SAMN04489712_12193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="428" mass="46529" checksum="2DF3682A34F2BCC7" modified="2017-01-18" version="1">MARPTQSVDPQKSLRHLVGATIRHWREVSGMSVIDFARDLCIDPSHLSKWERGLAPVPADQISRIDRILNADNHIAAVHAAAAELEEHRTRNRATLEAANQYETDGQDVKRRAVLQLLTALGAGAAIPPGVLEEILSGVTPALDDHVDLDEWERTVQEYSHMINMRPIGALIPDLTADLVTVSRLLDRRYAPLVHAGLFRVSAGLSGLLATQLDDVGDRRAARVAWSSARRAADASGDRALSVWARGDEANEATWTGRPTQVVSDLADEAIEMAGGVPSRGLGRAYAARARLAADEGDKAAAFAALDALADVVDHELRDFPERHLRWNQAYVYTLVGDPRAESALDQAFALYPPGTLGPVSNLRLIRAVGLVRHREVEEGIRHAITALEEGPVSATRRHLTGHIVKTLPDKARTLPDTRELRALASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU08</accession>
    <name>A0A1H6DU08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88075">
        <property type="protein sequence ID" value="SEG88075"/>
        <property type="gene ID" value="SAMN04489712_12170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="398" mass="42796" checksum="8B5E7FA61D969187" modified="2017-01-18" version="1">MTRAQGSLMDAQPVPEPRSAVEPDATRAGEPPDLLSRLRAADRRAVPEAADDCGHQLRGFVARGRSRVLVVVLARLVAGGLPGPVNWAAATVSVLVMGAWPYLLALLSWAVQGTDPLHGGTGHLFALATTLTCVAMLALGWTAWQWAPSLADCTAQLLAPSPQRDDFIGWLRGRLRLLPQLSACGAGAGAAALLVFALSHQHGDALPAGVWTYLIAAWTGLMGGEVVYWLYTIAEVPLRLYRCEGLQMTWIDPAHTPAVVQLCRVYARVAVCMALGVLLVELSTLAVTGDRPGPLMQGFAIGLPVFAAVTAIHVGIQPYVTLSRLVRRHIDHIVNPLMAQVTHPPGDLLPHPELDRAFAVYAHFRALRHLPIRTATLLQYVTGILASLIVFFVQRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUQ0</accession>
    <name>A0A1H6DUQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88774">
        <property type="protein sequence ID" value="SEG88774"/>
        <property type="gene ID" value="SAMN04489712_12277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG88774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="273" mass="30687" checksum="F0ACDF0CA5611EB8" modified="2017-01-18" version="1">MAESRAGNTVESIYQTLRERIIDGAYAPGIRLSQGGLAEELQVSRTPLREALHRLEADGLVLSEANRGMQVAPTTPAHVEQYYGLRLLVEPPTVAGILADLTDGDLTRMAEDLERMENDGRRIRDFQEAHLRFHQTALGRYPTAWAELTESLHLKIYRHQRLYLSHPEAPEDFTRLDRLLLEAMRDRDAELTRQVLEFHLIDAALGLVLDQNPDHVFTSLPLAARGVGVDLGITADRLITRPATLRWLRPGVRSALDLSTANLRHVRTEGESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DV22</accession>
    <name>A0A1H6DV22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88556">
        <property type="protein sequence ID" value="SEG88556"/>
        <property type="gene ID" value="SAMN04489712_12230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="52"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="460" mass="51335" checksum="FA5AF09F6588E30C" modified="2017-01-18" version="1">MSASTEETATGLSDALVDWMAGAVRGKIVSFERRPGGGRREAWFVDAETADGTRLELFLRYDRGRADEAEDPFTLQNEARYFLALQDSAVPVPRIHAVHPTEQAILAERVPGQTWFSRLRGEAQRLSIAREFMGILAALHAVDPRRVLPPDRSPETDLRDLVHAEIDRWEALYRRSTEPADPLIDLGLAWVRQNVPDVSEPAVIVQGDTGPGNFLYQDGRVTAVLDWELAHLGDPHDDLAWVTVRAVQEPFTHIPDRLADYAAASGRAVDLDRIRYYRVLAELRILILGHQSSRKTALLSEVGNGLIYMALHRRLMVEALADATGTKIDPPAPLPATACDNEWLYDAAIAQIGEIIVPRSEDPFVILRSKGVARILKYLRESERLADAKRHRDLEDLESLLGTRPDTVAEGLARLSEGLRHGAVTLSAALPVLYRWVLRETQVCRPAMGRLAERRFDPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVF0</accession>
    <name>A0A1H6DVF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88723">
        <property type="protein sequence ID" value="SEG88723"/>
        <property type="gene ID" value="SAMN04489712_12266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG88723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="215" mass="23288" checksum="B2AB46C231E732F4" modified="2017-01-18" version="1">MTRLLLVDDQQLTRSGLIRIFDGEPDLEVVGECADGDEVERAAVRHRPDVVLMDVRMRRMDGAEATRLLQRRPGAPAVLILTMFDDPDVVAAALTAGAAGFVLKDAPGEEIIQATRAVAAGKGWLDPAVVPQIFDAYRSDLRPRQAETALVVELSRREREVLSLIGVGATNAEIAARLNIAEGTVKTHIGHIFTKLELRDRAAAVIFALRHGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVU4</accession>
    <name>A0A1H6DVU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diadenosine tetraphosphate (Ap4A) hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89194">
        <property type="protein sequence ID" value="SEG89194"/>
        <property type="gene ID" value="SAMN04489712_12339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="5">
        <location>
            <begin position="69"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="163"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG89194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="22315" checksum="0DE497B189169111" modified="2017-01-18" version="1">MSVEPREPDMPQARFDAPGSAGRTMCEVEEERGGAGAPDSFQRLWTPHRMAYIKGEGKPTGAGPEDGCPFCEIPKMDDVEGLIVARGDVVFVVLNLYPYNSGHLMVVPYRHIADYTELDPAETAELAEFTKRSLTALRKASGAQGFNVGLNLGGVAGAGIAAHLHQHIVPRWGGDTNFMPVIGHTKVLPQLLRDTRQLLADAWPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWN2</accession>
    <name>A0A1H6DWN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89668">
        <property type="protein sequence ID" value="SEG89668"/>
        <property type="gene ID" value="SAMN04489712_12421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="381" mass="41455" checksum="96E45C10AA7EF705" modified="2017-01-18" version="1">MDEITMVRELYGSPEPDPAARERIRARVVGGRPVRRPHRRMTFGLGLVAAATAVVAGASLLSGGTTRTPVVLGTTGGDDGSARSILLAAADSAEKEQPGRYWRLHTTYADTYRVKAGYNVEGNRWESDRWMARSKDEPDHNFDRDLPSRPQTPADEAAWRRAGSPKTWKVISSGRPYTLTTESTGWRSATISAEQKRRRDDRACGDGSPAGPQGCNPMLGPSTEERVLTDPGLFRKSHAELRAKRVRALVESEPHLEKEAAARFDLPIISLFLTTRPASPQVRAAAFRLLADTPGIRSIGTVTDRAGRRGIGLAARATKDDGGGTVYDEVLILEPKTYRILGEQQMIVKAAGPYRGMAPGTVLSHTVVHHAGWTDAKPAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ25</accession>
    <name>A0A1H6DZ25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90016">
        <property type="protein sequence ID" value="SEG90016"/>
        <property type="gene ID" value="SAMN04489712_12514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296330" evidence="1">
        <location>
            <begin position="27"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="648" mass="70097" checksum="FFB2737F361746F5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0B9</accession>
    <name>A0A1H6E0B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91022">
        <property type="protein sequence ID" value="SEG91022"/>
        <property type="gene ID" value="SAMN04489712_12816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="48" mass="5340" checksum="6A13DAF3EB6C4D0B" modified="2017-01-18" version="1">MAAPGKDALGRFVPTVPADHLRSVWLLARREFGEEFPGVVVWFGLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0D0</accession>
    <name>A0A1H6E0D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90375">
        <property type="protein sequence ID" value="SEG90375"/>
        <property type="gene ID" value="SAMN04489712_12618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG90375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="432" mass="47344" checksum="AB293F9DA0B32D39" modified="2017-01-18" version="1">MTEDGRRLFLAYNVRSYGVSPRAWLSPQLTGREIFTADYWSRITRLAEKGLFDAVFAGDSSQFLGFNRIDIDGVDRFVAWASVVPHTERIGVIVTASTTYNDPYRLAERLLSLDLLSDGRVSWNLVTTFAEDAAANFGLARHPERGLRYRRAEEFAEVVVGLWDSAGDGPAVAHRGENFTVSGRLPLPRSPQGRPPIIRASSSDEGRRLAGRLAAAVFDSALTVTEAQERYRKVKSDARDAGRDPADLAYLPGLRIVLASTTAEAKARVDELFTQDPITRSEHESWFGGLIGANVADLDPDKPIPATVLEAATAAATADRDHLRASTLRVLADGPQIPLSEHLLRTRYLSGGHGTFVGAPEHLADRMEHWFRSYAADGFVIAPDLVTETLPILVEEVVPLLQRRGIYKHEYAASTLAGHFRAAAGRLSEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0R9</accession>
    <name>A0A1H6E0R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein YeaO, DUF488 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91208">
        <property type="protein sequence ID" value="SEG91208"/>
        <property type="gene ID" value="SAMN04489712_12862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="14317" checksum="E646873DCDDC10B3" modified="2017-01-18" version="1">MIEIRRVYDAPPERGAVFLVDRMWPRGKRKEDLSLDGWLREVAPSTELRRWFGHRPERFAEFAERYRRELDAAPDAVRPLLEAARQGPLTLLYSAKDTEHNQAVVLRDYLRDRLGDEDDPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E262</accession>
    <name>A0A1H6E262_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91768">
        <property type="protein sequence ID" value="SEG91768"/>
        <property type="gene ID" value="SAMN04489712_13045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="146" mass="16650" checksum="5A99DC97683FBD46" modified="2017-01-18" version="1">MISAMEVLTLQRRFRPWRYGVSHSELLMHGHADANGDEHINVLFEDVRAVKLRTFYDPLVLQPADEQTRLSILDFAQVPARFHARFLCLTLPTPDAEPGFIACARATVLSTSTDRAGIYDWTDRSRVLHDLRPIEPRDPHSTEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2B7</accession>
    <name>A0A1H6E2B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinol monooxygenase YgiN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91055">
        <property type="protein sequence ID" value="SEG91055"/>
        <property type="gene ID" value="SAMN04489712_12824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="11721" checksum="E64D391A87435F3D" modified="2017-01-18" version="1">MFGLVVRFTCKDEASAEEFDRLVGETVEKIRELEPGTFVYATHRVEGQPLQRIFYELYRDREAFDAHEAQEHTKRFLGARDELLASVEVDWLELQAGKGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2B8</accession>
    <name>A0A1H6E2B8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91459">
        <property type="protein sequence ID" value="SEG91459"/>
        <property type="gene ID" value="SAMN04489712_12924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG91459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="14606" checksum="0C1E0FD15FBA2DBB" modified="2017-01-18" version="1">MNPNIRAGDELPPLKVPPISRTTLALYAGASGDHNPMHIDLDVARSAGLDDVFAHGMLSMAYLGRLLTGWTRQENIRALAVRFTAVTPLYAEPVCTGTVTAIEDGAAHLDVAVTLADGTTTLRGTAVVDLPAGREDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2P6</accession>
    <name>A0A1H6E2P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-terminal half of MaoC dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91463">
        <property type="protein sequence ID" value="SEG91463"/>
        <property type="gene ID" value="SAMN04489712_12925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16410" checksum="A82AD4063465D446" modified="2017-01-18" version="1">MAIDTSVIGTTAPELTVDVERGRLRSFAHAIGETDPIYTDVDAARAAGHPDLPVPPTFLFCLEMDRPDPFGWLDGLGVDLRRVLHGEQRFTYRTMAHAGDRLTLAARIGDVYAKRGGALEFIVRSIDVTRDAVPIAELASVIVVQNPEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3L8</accession>
    <name>A0A1H6E3L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92278">
        <property type="protein sequence ID" value="SEG92278"/>
        <property type="gene ID" value="SAMN04489712_1333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="7098" checksum="122FB7124FE72838" modified="2017-01-18" version="1">MRDDRDFVALMSFVSGLFAAVLLLAPPGDRWQAYVSACVCTGLMLLFGVSWTVMTVASALDARARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4S0</accession>
    <name>A0A1H6E4S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinol monooxygenase YgiN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91875">
        <property type="protein sequence ID" value="SEG91875"/>
        <property type="gene ID" value="SAMN04489712_13110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="100" mass="11605" checksum="FE58DFFA810808F3" modified="2017-01-18" version="1">MIVVSGFMEVAPDYADRFAACTRELVDATRREPGCVEYRFARSIEKAERFEVFEEFVDQAALDEHVRADHYRSWNRALKDIEVTQVSIVKYIATERTVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5B1</accession>
    <name>A0A1H6E5B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92948">
        <property type="protein sequence ID" value="SEG92948"/>
        <property type="gene ID" value="SAMN04489712_13624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="29477" checksum="A6B6E4574EB2A7B1" modified="2017-01-18" version="1">MNADSEVKTDARRLRVDGVDVDLGGVRILRGVTFDVRPGEVFGIVGPNGAGKTTILNVIDGIVRPSAGTVRYGDVDLCRVRPHDMRKHGIGRSLQSTHYFRDLTALQLVALGELPNSIVGALRFAGHRKRRKAQAEARDKGMEALRQFGLEQYANRPLSELSSAVQKLVDIARAVVTGGELLLLDEPTSGVSGHERGGIGEALRRLRTLGRTIVLIDHDPGFVTGNCDRLMAMNFGEVLDVGLPDEVMSSEAVKRSYLGESANTDVGIERDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6T1</accession>
    <name>A0A1H6E6T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_13632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92971">
        <property type="protein sequence ID" value="SEG92971"/>
        <property type="gene ID" value="SAMN04489712_13632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="226"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG92971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="385" mass="41683" checksum="083B5EEA2A229312" modified="2017-01-18" version="1">MDFGIGERGQALRAEVRAFLKEHLTDELAERCHRTGVAHDDAFVRAMHEAGLLALGWPEEWGGRPCDPLGLSVVEEELSKAEAPTYGVSTTHMVARAILRCGNDRQRAEIIPRAVRGEILIVLGFTEPECGSDLAAARTRAVRDGDEWVINGSKMFTTNAHIGDYVFLLARTGTTSKHEGLTVFLVPADQPGIEAQAVRTISGERTNITYYRDARVHDDWRIGDVGGGWRVLGEALQEEHSVGFGASMLRLLEAAEGWARTARGNSGRPRITDPDVRERLGRCAAEAEVSLLLQRRAAAMAGQGVVPVAEGPMAKLFSSEALTRAAEDLFDLLGPDALRGHLSPGAPEGGRVEHALRFSLGTTIYGGTSEIQRGIIARRGLGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7F9</accession>
    <name>A0A1H6E7F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93650">
        <property type="protein sequence ID" value="SEG93650"/>
        <property type="gene ID" value="SAMN04489712_1404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="131" mass="13731" checksum="D032BFF0329C5291" modified="2017-01-18" version="1">MTATDANAGAGTSVRPAIDPADFRATLSRFCSGVTVLAGFGEDGAPVGLTCQSFTSLSLTPPLVLVCPGRNSTSWPRIGRSGRFSVNVLAQDQQNVCSALGRSGPDKFTGVRWRRTDRGALVIDGAIAWMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8M4</accession>
    <name>A0A1H6E8M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94072">
        <property type="protein sequence ID" value="SEG94072"/>
        <property type="gene ID" value="SAMN04489712_1433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="22041" checksum="CC2BFA3DE66ECDDB" modified="2017-01-18" version="1">MIGSIERIVDVAALIEFLFGPGEGERHENPRLVGGYPDLFLEPFLEPEPRADGSWDCGFLIRTLQPPKDRDDLVAEPIWHCELRTWPGEGVLSDDEWGQVALEVAIQNGVAIDDEDHASIAPWTAIRHAEDHIHIVMCLYGFEGRQLYLSRDRLQVPHACAIVEDRHRLWARRLRSLDERHLDDENPDDPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9R2</accession>
    <name>A0A1H6E9R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93983">
        <property type="protein sequence ID" value="SEG93983"/>
        <property type="gene ID" value="SAMN04489712_14217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="260" mass="26637" checksum="30E7853E54489AB8" modified="2017-01-18" version="1">MIMTSVDRGTARLTLNNPRRKNAITLEMAAMIEEFCDRVHADEAIGAVIVDAEAGYFCSGADTRDLASSSADPASPEAVARTSAVYNAFVGVGRLPVPTVSLVAGGAVGAGLNLALATDLMIVTPDAVLDSGFLARGIHPGGGHLALLGRAVGYQQAVALGVLGAALSGTEAVRRGLAWVAVEPGELLETATRLVAKAAADPALARRIKNSAVVELGPPAVSWPAAVEIERGVQMWSLGRKGDAGWARKPDKPVVGGNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB17</accession>
    <name>A0A1H6EB17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_14316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94124">
        <property type="protein sequence ID" value="SEG94124"/>
        <property type="gene ID" value="SAMN04489712_14316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="619" mass="69189" checksum="4B5274FEC15952A8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBY6</accession>
    <name>A0A1H6EBY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000051">
        <property type="protein sequence ID" value="SEG94783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94783">
        <property type="protein sequence ID" value="SEG94783"/>
        <property type="gene ID" value="SAMN04489712_1516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="363" mass="40051" checksum="A1C56260F1165956" modified="2017-01-18" version="1">MAATRTKGDTVETQDKDLVGAYLDRIGRTHLLDAQEEVDLAKAIEGGLYAEHLLEEGRVPAGVTRQELEELAAAGLRAKQRFVEANLRLVVSIARKYPTDSLPLIDLIQEGNLGLMRAVEKFDYRRGFKFSTYATWWIRQAIGRGLSHTARTIRLPVHVEEELSRLRRAERQLGRELGREPTRDELAHALGAVPDHVDELLRWRRDPASLDAAVDDAGETPMGDLLEDPDGVSPEAEVLALDDLAGLGRLLERLPEREAAILRARFGIEDGQPLSYAQIGARYGLSHNRVRQITDRSLRRLRQLAAEGDHVGRATGHPAQPARAGQPAPARQAPQGPRTAEHIAHAPCAPRRELPAPVPTKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SCW2</accession>
    <name>A0A1H5SCW2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ORF">SAMN04489712_101157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48335">
        <property type="protein sequence ID" value="SEF48335"/>
        <property type="gene ID" value="SAMN04489712_101157"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="153"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF48335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="313" mass="33854" checksum="3F1648EF4AC2CC3E" modified="2017-01-18" version="1">MKRHLISAADLTRDDALLVLDTAEELAQVADRSIKKLPTLRGRTVVNLFFEDSTRTRISFEAAAKRLSADVINFSVKGSSVSKGESLKDTALTLEAMGADGVVIRHSASGAPHRLANWVRGSVINAGDGTHEHPTQALLDAFTMRRRLGDLAGRKVTIVGDVLHSRVARSNVLLLHTLGADVTLVAPPTLLPVAVDTWPCSVSYDLDAVLPKSDVVMMLRVQRERMNAAYFPTVREYSRRYGLDADRVARLADHAIVMHPGPMNRGVEIAAEVADSPRSTIVEQVANGVSARMAVLYLLLGGSEPAIGKEVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SEM3</accession>
    <name>A0A1H5SEM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49042">
        <property type="protein sequence ID" value="SEF49042"/>
        <property type="gene ID" value="SAMN04489712_101178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="153" mass="16792" checksum="DEBCA304B46871E2" modified="2017-01-18" version="1">MKAVPDQPPPPHIELTELVFRVAGRLRDCFTAAAADLDLPPAQAQALANLDFPAPMRKLADVMACDASNVTGIVDGLERRGLVLRQPDPHDRRVKLVVLTDEGHRRRQALRTHSAEAAAQVFGLPPDDQRALRDLLTRVATNHTGQNPYRCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SN12</accession>
    <name>A0A1H5SN12_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="9">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">murD</name>
        <name evidence="11" type="ORF">SAMN04489712_101262</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51348">
        <property type="protein sequence ID" value="SEF51348"/>
        <property type="gene ID" value="SAMN04489712_101262"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
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    <keyword evidence="5 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="116"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF51348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="469" mass="47880" checksum="CC6206BF57D231FC" modified="2017-01-18" version="1">MNWKDSAVCVAGLGVSGRAAARVLAERGARVTVVDARDDEAAREQAAALAAHGVTVRLGDGGTLPPGTELVVVSPGWRPDAPLPAAAAAAGIEIYGEVELAWRLRPEGAAPWLALTGTNGKTTAVRMLACVLRAAGHRPLAVGNVGTPIVEAVLDPSYDVLAVELSSYQLHWSSTVAPLAAAVLNVAPDHIDWHGSLEAYAADKGRIYAPGAIAVVNADDPICVRLAEGARRTVGFTLGVPAPGQLGVVEDLLVDRAFTADPVREAAELAGLGDVRPFAPHNVANALAAAALARAYGVLPEAVREGLRAFVPDPHRIAHVATVAGVDYVDDSKATNPHAAAASLAACESAVWIAGGLLKGADVEDLVRSCAPRLRAAVLIGADRAQIADALARHAPDVPVVDVAATDTGAMDTVVTEASRLARPGDTVLLAPAGASFDMFASYGARGDAFAAAVRRLAESAAGSPDAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SQL0</accession>
    <name>A0A1H5SQL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_101324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52886">
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        <property type="gene ID" value="SAMN04489712_101324"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="33"/>
            <end position="319"/>
        </location>
    </feature>
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        <location>
            <begin position="352"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="403"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF52886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="631" mass="66942" checksum="7C290F08C835505C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T0A1</accession>
    <name>A0A1H5T0A1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase conserved C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55467">
        <property type="protein sequence ID" value="SEF55467"/>
        <property type="gene ID" value="SAMN04489712_101408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="DUF3516"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="41"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="257"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF55467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="836" mass="92739" checksum="7844D945F1083698" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T8N0</accession>
    <name>A0A1H5T8N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58508">
        <property type="protein sequence ID" value="SEF58508"/>
        <property type="gene ID" value="SAMN04489712_101505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF58508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="26569" checksum="09042141BC116815" modified="2017-01-18" version="1">MDMAKKVAVVVGGGSGMGRATAELLAERGATVAVLDLPQGKGPQAVAEIGGDATFHPCDVTDETGTEQALDAVLERHGAVHIAVNTAGGGYSKRTISRQGPLPLADFRKIVELNLIATFNLNRLQAWHMSKNEPDEQGERGVIVNTSSIAAFEGQIGQVAYTAAKAGIAGMSLTMARDLGGLGIRVTAIAPSLFATGLLEGAPPALIADLTRDAAFPKRAGLPHEFAWLAEAIIKNPMLNGQTIRLDGGQRFAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TBC6</accession>
    <name>A0A1H5TBC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59297">
        <property type="protein sequence ID" value="SEF59297"/>
        <property type="gene ID" value="SAMN04489712_101529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF59297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="361" mass="39147" checksum="4741B09D843BFB71" modified="2017-01-18" version="1">MPGAVLGRALGRARHQGERDPEFGGTGQRAAQDSGEHPGVVQGVVRPPLPDAVVGGQCAQPHVGSGRSDPPVQCQRAQPPLDRQPQTGPGEFTRQEVVVERRVVRDHHPAFEHRRDPLGDLVERRGTPQPLGGQPVDVHRAGVAAGVEQCGELLDGLAVRPEREHRQRQHTVLGGPQAGRLDVHERPVVGVGERPGHVPDGGELGHGGKDARTVRRYGWEQGHSFTLPRPREDGRDLQRLPLGLTRRRRLAGFPGFLDAVTNGRRTAATAAPLFTSVNRSVRACRRIRWPSHRLGWTRRSMGREKSSCSGAVSAQHEIPDAGSGRSGDRFGRACRNGPTSGAERWSDVPPRFSPLLGRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TI11</accession>
    <name>A0A1H5TI11_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62416">
        <property type="protein sequence ID" value="SEF62416"/>
        <property type="gene ID" value="SAMN04489712_101627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF62416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="386" mass="41028" checksum="2581D89DDB15B260" modified="2017-01-18" version="1">MEGRDPVSGVTMGVEEEFLLVDPVTGVTVPRAARVLALAGRRPPPAPGAGFHAELQSTQVEAVTGVCTGLRALRHQLRQGRLRLAAAAAAEGVRLVSTGTPVLACPDPPFTEGERFTRISRMYAGVVGGYQSCGCHVHVGVQDRETAVGVLNHLRPWLPTLLALSVNSPFDRGRDTGYAGWRMMEQSRFPGSGVPPWSDSAAGYDRQVERLVDGGVLVDPAMTFWLARLSPRLRTVEVRVADAAGTVDEAVLQAALTRALVRRALDDLAAGREAPRVCDQVCAAAVWSAARYGLEGPGVHPVREAQVHATALVDELLDRVRPALEEAGDLSEVQTVLAKIRRVGTGAARQRRAAGGAGPAGAIPMLVQQTAPGAWEPPERVRMGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TQD9</accession>
    <name>A0A1H5TQD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65082">
        <property type="protein sequence ID" value="SEF65082"/>
        <property type="gene ID" value="SAMN04489712_101711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="226"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF65082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="477" mass="49679" checksum="35DFA08837C7F8AD" modified="2017-01-18" version="1">MTASAIGRPAVADPGSRDAAQRLSRLLDPGSLSPLREPGATGVHTARGLIEGAKAVAFCTDATVMGGALGAAGCDDIVAAIDTAVRERCPVIGIWHCGGARIDEGVRSLEGVGRVFAAIVRASGRVPQLSVVVGPAAGGAAYGPALTDLVIMAPDARLFVTGPDVVRDVTGEDVTMADLGGPEPHGRRSGVCHVRADSEDDAYVRARRIATLLGRPGVFDPRLVQDEDDLRQLLPARPNRAYDVKPLLRRILDGPATGAEGLEEVQAAWAPNMVVGFGRLGGRTVGVVANNPLRKGGCLDSLSAEKAARFVRMCDSFGVPLVVVVDVPGFLPGVGQEWDGVIRRGAKLLHAFAEAVVPRVTLVTRKSYGGAYVAMNSRSLGATAVFAWPEAETSVMGAEPAVRILYRRRLAAAPPEEREALRAALVAEHQRTTGGLHVAVAQGAVDEVIDPARTRRTLAEALAGAPAGRGSHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TV05</accession>
    <name>A0A1H5TV05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 6">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 6"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66048">
        <property type="protein sequence ID" value="SEF66048"/>
        <property type="gene ID" value="SAMN04489712_101738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF66048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="31687" checksum="C35D4D3F2412A541" modified="2017-01-18" version="1">MRGIILAGGNGTRLHPATLAVSKQLLPVGDKPMIYYPLSVLMLAGIRDILVITMPSDTPQFRRLLGDGAHLGLNITYAWQDEPRGIAEAFLIGAEHVGDDDVALVLGDNIFHGNAFSDLLARESANLSGCTLFGYPVTDPERYGVGETDGAGRLVSIEEKPLRPRSNRAITGLYFYDNDVLELARDLRPSGRGELEITDLNHAYLKRGQARLVDLGRGFAWLDTGTPESLLQASMYVRTLEERQGVRIACIEEVALRMGYIGAEQCHRLGASIGKSAYGQYVMAIADELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TWN5</accession>
    <name>A0A1H5TWN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67272">
        <property type="protein sequence ID" value="SEF67272"/>
        <property type="gene ID" value="SAMN04489712_101776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="13"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="128"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="239"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF67272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="43157" checksum="6A5FDDCE043994A5" modified="2017-01-18" version="1">MAVDLTPDPSVAQLAQRTAQFVRQVVVPVEERERGVARSEEVRVELQRAAREAGVFAPHVSAEFGGHGLDMRGRAAVFEEAGYSLLGPLALNIAAPDEGNMHMLEAIATEEQKERYLRPLAAGEVRSCFAMTEPAPGAGSDPAALTTRAERVPGGWRIDGRKWFITGAEGAGFAICMARTAGEPGDAGGATMFLVDADNPGMKTVRHIETLDESLYGGHIELLFDGCVVPDEAVLGEVDQGFRYAQVRLGPARMTHCMRWLGIARRAQDIAVARAAERRLFGSRLGDLGMVQQMIADNEIDIAAARGLITQACWELDQGGHASQSVSIAKTFCAEAVWRVVDRALQICGSLGVSGDILLSRFLREVRPFRIYDGPSETHRWSIARRVLREHDKTAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U134</accession>
    <name>A0A1H5U134_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68710">
        <property type="protein sequence ID" value="SEF68710"/>
        <property type="gene ID" value="SAMN04489712_101826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="10"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF68710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="490" mass="52010" checksum="966E5EEB789BDADD" modified="2017-01-18" version="1">MTTENLGRFDVVVVGAGTGGLCTAIEAATGGARVLLIDKQQEIGGMLHIANGEFSGAGTRRQAAHGISDTPEEHFAEVMRLSHGKADERLAWQTVRAQGRTVDWLESQGFEFDPATPGLVHGHEVYSVPRTYWGVRAGLSVIDALRPLLDGLVEQGAVTVRFGVRIEGAVVEDGRVAGVTGTGPDGGEVTAYGDAVVLATGGYDANLELRNRFLPPGCENALIACLDHATGDGLVLAEELGAGISGDGYFIPVMGLIPDPGRPGFAVDYREAFVEVAPAYRTPYEIWVNRDGERFVAEDTTSPEHRERALLRQPGIEMHIIWDQAIAAAAEPLIRNGAGDWTPERMRDEHSRGRWIVAADSLEELAGKLGVSPGGLVETVRRYNEAVAAGHDPDHGRTTLPIPISQAPYYALTSVAASLLSRDGLRVNGELAVLDREGDPIPGLYAVGEVLGNNVFAGDNYVGGMSVTPAMTLGRELGRALAARRGSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VFR3</accession>
    <name>A0A1H5VFR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86192">
        <property type="protein sequence ID" value="SEF86192"/>
        <property type="gene ID" value="SAMN04489712_102308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF86192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="85" mass="9676" checksum="8D128AB4703A7B79" modified="2017-01-18" version="1">MSQTMTDRMGELREIVADVLEVEPEEITDDGLFTEDHDADSLQAIDVLARIEKTYKVDIPQSELPNMNTLQDVYKVVASYAGWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VGF5</accession>
    <name>A0A1H5VGF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted ester cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85881">
        <property type="protein sequence ID" value="SEF85881"/>
        <property type="gene ID" value="SAMN04489712_102297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF85881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="153" mass="17048" checksum="85F7314890B33959" modified="2017-01-18" version="1">MAQDPLEIAYHMSAVFNDCDEEAAYTYVADDFVDHEAPPGTPGGPGGYLATARFMNEVFADATWEHLHSFSSGDLALIHVRFTGRHVGDFLGVAPTGREVSIEHMHMYRVADGKVVEHWGCRQDLFLMLQLGMVELELRPFVPEAQLAELRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VPE2</accession>
    <name>A0A1H5VPE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88788">
        <property type="protein sequence ID" value="SEF88788"/>
        <property type="gene ID" value="SAMN04489712_102391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF88788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24562" checksum="A52D4B0AFACEA93D" modified="2017-01-18" version="1">MSRADRERQMLDMAEEVFAERGYRAASMEEIAERCGVSKPMLYEYFGSKDGLLTAAIDRSKAELYEATRAAMDRATTPQDVVWRGMLAYFEFMDAHSRSFAMLLQEPLVATPATGEAIEQTRRQQSGLIAPIIAALAPEMPRPAVEAYTEIIIGACERLAVWRLRHPEVTAHDAARYMTDFTWNAMRHHLQAPVSGPAPAPDVPGSEGSPDDLTGPPHRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VWL1</accession>
    <name>A0A1H5VWL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-amino acid N-acyltransferase YncA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91241">
        <property type="protein sequence ID" value="SEF91241"/>
        <property type="gene ID" value="SAMN04489712_102478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF91241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="161" mass="17930" checksum="3FC9C7CE1856F8CE" modified="2017-01-18" version="1">MDVEIRDAVWADAAMVAELDRRTWSPDSAVMPRPGPDDMSFDAAHPPEDYMVAVLEDRIVGYVRLVQPVRLPSGAHVRQIQGLAVDPAEQGRGLGRVLLDAACERARQQGARRITLRVLSTNPRAIRLYERAGFTVEGVLPGEFHIEDRYVDDVLMGRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VXH6</accession>
    <name>A0A1H5VXH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">SAMN04489712_102496</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91708">
        <property type="protein sequence ID" value="SEF91708"/>
        <property type="gene ID" value="SAMN04489712_102496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF91708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="33265" checksum="54BE63D4285D4355" modified="2017-01-18" version="1">MGAQLRQLRRQIRSVKSTAKITRAQEMIATSRIVKAQQAVEASKPYADQITRALTALVSHHVGIDHPLLKEQPEDRRSAVLVITSDRGFCGAYNANVIREAEALMALLREQGREPVPYVIGNKGITWYKFRNRELAAEWQGLSDRPDFASAERVGRRLTEDFIKTDAEGGVGEIHVVYTEFVSMLTQQVQVRRLLPLEIEEATSDVVLPAYEFEPSAQAALDLLLPNYVESRIFHMLLQSAASFHASVRRAMKSATDNANELIGVYSRMANQARQAEITQEISEIVGGADALAESSAGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W994</accession>
    <name>A0A1H5W994_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95938">
        <property type="protein sequence ID" value="SEF95938"/>
        <property type="gene ID" value="SAMN04489712_102633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045596">
        <property type="entry name" value="DUF6459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20060">
        <property type="entry name" value="DUF6459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF95938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="13457" checksum="ADB8304B3CF2C7E9" modified="2017-01-18" version="1">MSSGGPVLRAVGAQVPDEALQVVVAATLRLVAEVLAGTRPARQLTRRATPQVCEELAAFAVPPGGPVRPPRVLTSWVQEPAPGTAEAGAVIALAGRVQALALRLEHHRGRWRCTVLETTAPHRRAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X1B6</accession>
    <name>A0A1H5X1B6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_10350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05592">
        <property type="protein sequence ID" value="SEG05592"/>
        <property type="gene ID" value="SAMN04489712_10350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="460"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG05592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="558" mass="58238" checksum="7E0863388C0B58A2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X4V7</accession>
    <name>A0A1H5X4V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06794">
        <property type="protein sequence ID" value="SEG06794"/>
        <property type="gene ID" value="SAMN04489712_10389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG06794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="30743" checksum="C48F7654617E3764" modified="2017-01-18" version="1">MFARRYEELTEIRATRPEEIARAADRRVRRPWPAGVRGRLMIVAADHAARGVLGAGDAPLVMADRRDLLERLCTALERPGVDGVLGTPDVIEDLLLLGALDGKVVLGSMNRGGLAGARFEIDDRFTAYDVPAIRAGGLDGGKMLLRVDDEDPATARTLRACALAVSGLAAHRRMAVVEPFVSRREPGGRLRNVLTCEAMIRAVSVAAGLGGTSAYTWLKVPVVPDMERVMAASTLPALLLGGESGLDSALPAWQKALSLPSVRGLVAGRALLYPPDDDVAAAVDAAVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X8M0</accession>
    <name>A0A1H5X8M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07983">
        <property type="protein sequence ID" value="SEG07983"/>
        <property type="gene ID" value="SAMN04489712_103137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="25"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG07983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="233" mass="24585" checksum="0C313B2D00371076" modified="2017-01-18" version="1">MAFGIGKGGTGTMHVRLPFVDRAEAGRVLGELLVPYDLEDPLVLALPRGGVPVAVEVAGRLGGPDRPAGLDVLVTRKIGYPPQPELGVGAIAEGGEPVFDHDLLDRLDLTEEDLAGTVEAERAELARRVRVYRGGRPLPDPAGRDVVVVDDGLATGGTARAALRAIRPRGPARLLLAVPVGAPETVRMLREEADEVVACATPAAFRAVGQWYRDFEQLTDADVNALLEGRAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XC13</accession>
    <name>A0A1H5XC13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG09272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG09272">
        <property type="protein sequence ID" value="SEG09272"/>
        <property type="gene ID" value="SAMN04489712_103186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="140"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG09272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="701" mass="79109" checksum="096E1A745A680C32" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XV10</accession>
    <name>A0A1H5XV10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15594">
        <property type="protein sequence ID" value="SEG15594"/>
        <property type="gene ID" value="SAMN04489712_103424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG15594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="23424" checksum="A7BF5D84DD28B27C" modified="2017-01-18" version="1">MTRQVIEVHELTAGHGGAEAVRGASFTVAQGTVYALLGRYGSGKTTLLETVAGYRRPMSGTVRVAGVDPYAPGETLRMGTVWREGGLFPGLTVAEVVDTWRRWTLDPLTREEALERVGLQGKAGARFERLGAGDRRRLDLALALVGRSDVLFLDEPTAGLPREDARRIRATLRELASGGVTVLLTTRDPDEACGADRIGVLNDGRLATGRAPIRLYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y214</accession>
    <name>A0A1H5Y214_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17892">
        <property type="protein sequence ID" value="SEG17892"/>
        <property type="gene ID" value="SAMN04489712_103513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="93"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG17892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="269" mass="29867" checksum="566BCEA36CB8093E" modified="2017-01-18" version="1">MPELDPKQSARAFYARALARERTRASLTQSALGAHPAVMVSGKLIGHIENGRRPPTLRISKAFDKALDLEEHFEALYGIMVREEGEPPAIYEYFDLETRASSIKTYDCLWINGLLQTEETAREILSAAHSVDKADEFVAARMERQEILRRETPPWLMIAMDEFCIRRVVGSREITRRQLEHVLTMMQEPNINVVIVPAGAPIYPAGSFALIGFPDSADVGYVEAASGHGRTLAPGPKVKGLALLSDRIASMALPVPDSEKLIRTVMEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YIV6</accession>
    <name>A0A1H5YIV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG23306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG23306">
        <property type="protein sequence ID" value="SEG23306"/>
        <property type="gene ID" value="SAMN04489712_1047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG23306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="38817" checksum="E9F806B1F2085EFF" modified="2017-01-18" version="1">MTHSLEEHGTEREGPLSLQEIDEIIGTENPPLRNLRITYAYHQLAVALARLLDDRNATWCGFGTWASRTAGLFIRGELKPRPVGLPPVPPWVSRHLMTWAAPHVGSNVARGNLLVFQELGPLFHTMVTAYTEEDDAERALERVLQPLRPGLVTEGGQDLLIAAARSYHRAMPLPHSAARSQVILLANLQVALHEQIRLQEAIAASLAPPLRAPFTPAPLNVLATRFWGRLATSHLMDVYMPAVDFTTTRTLIPLRLGRDVGGAHGATTFCEHLTDLIDLELKALLYDFDRSPNSVLGSAAADWSLLAERMNYLTDFFRLWQQDPCLMQAPFTPRQAEDLRAGKMPSGPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YM14</accession>
    <name>A0A1H5YM14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron(III) transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24416">
        <property type="protein sequence ID" value="SEG24416"/>
        <property type="gene ID" value="SAMN04489712_10457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009290685" evidence="3">
        <location>
            <begin position="27"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR002825-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG24416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="338" mass="35911" checksum="13966B8D842608E8" modified="2017-01-18" version="1">MRPSVTRCISALALAAVLLPLGTACGIGSEAGLVIYSGRNEGLIKPLLDKLEKAVGTDVEVRYGASAELSAQLLEEGDKTKADLFLSQDAGALGALAKQGRLEKLPQPTLDRVAKQFRAGGGEWVGVSGRVRVLAYHPGQVTKAPDSVHDLVKPEWKDKVGYAPTNASFQAFVTGMRVLEGDDATREWLKGLKANGIKAYDDNLALLDAVDSGQVALGMINHYYWYEKVAEKGADKVTAKLHYLPGGDPGALINVAGVGVLAGSEHNAAALKAVDFLLSKEAQTYFADETKEYPLASGVTSTVPDLPPLESLKAPEIDLGKLESLQQTLTMLREVGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZ50</accession>
    <name>A0A1H5YZ50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized membrane protein YckC, RDD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_104223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28446">
        <property type="protein sequence ID" value="SEG28446"/>
        <property type="gene ID" value="SAMN04489712_104223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="58"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG28446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="241" mass="26703" checksum="A8C8AD7E2C293C55" modified="2017-01-18" version="1">MSDPYRGGQPYNPHWQGGSPPGQWQRPPAQGQWQAPAHQGTGAYGGYHDPVATDLPLAPIHRRAAARLMDNALVAVFGFALVLPIAFGVIGLDAPGSKTRTEGGVWNWPIITTLFVVLAILPFLYEAVQLSMWGQTLGKRVLGMSVVRVDGQAMPVSQAAWRAAINNIGYQLGLFFFLILAVMVWEYAAYGLLLVTIGMLMAYLWAIWDQPLHQAMHDRFAHTVVVDDRVGHEDDHYHYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z4R9</accession>
    <name>A0A1H5Z4R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31539">
        <property type="protein sequence ID" value="SEG31539"/>
        <property type="gene ID" value="SAMN04489712_104362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG31539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="234" mass="26441" checksum="1CFF523CE2ADE7BE" modified="2017-01-18" version="1">MPPKLVSRRVSPSNISLLDAVAGVEPGAVSLHAMDLDAAGYECMARFLTERGELLRILKIRPGSRFYEYGDLQGVDFATHCPNLKTLDVKRVTFNGSVFAHPVLKDLRLQESKYVGDPRITVGEAQRLRKLEFDDCHVKADTLAVAPESQLKIFQYFLDEDYAEACPNHFEILGTRLEEITINACWAYTVTTNRASQRRNKYRTFRAGRYGSVTHIYYLGSGEKLVSHYESQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z6V9</accession>
    <name>A0A1H5Z6V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32012">
        <property type="protein sequence ID" value="SEG32012"/>
        <property type="gene ID" value="SAMN04489712_104389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="122"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG32012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="37441" checksum="73E1D2DDC8304D7A" modified="2017-01-18" version="1">MRTASAALKLGVFVAVTALVTGLLALTIANVRFTESVRYKAIFTDVAGLLENDDVRASGVRVGQVEDIKLRGTEAEVTFSVNKDGVFRAGLPRSVQLNLRYRNLVGQRYIELTDDAPGTAGEYLRPGETIPKERTRPALDLTVLFNGFRPLFKALDPQEVNTLAMQIVQTLQGEAGTVNSVLAHVASLTNTLANRDQVIGQVIDNLNTVLGTIDSRHDQVDKMITDLRGLVGGLAADREAIFDSVAAINQLTGTTTDLLKDVRPGLKNDIAGLNKLADTLGDHEKDLDRLFERTPNRMEELMAASSYGSWFNFYICGLDARIALPGGPVYRTPRIQNENARCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z9A2</accession>
    <name>A0A1H5Z9A2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="6" type="ORF">SAMN04489712_104420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32654">
        <property type="protein sequence ID" value="SEG32654"/>
        <property type="gene ID" value="SAMN04489712_104420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG32654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="132" mass="14382" checksum="1BEAA414F39D8A61" modified="2017-01-18" version="1">MTMTDPIADMLTRLRNANSAYHDTVAMPYSKIKAHIAEILQQEGYISAWHVEDAEVGKKLVIDLKFGPTRERSIAGIKRVSKPGLRVYAKKDNLPKVLGGLGVAIISTSSGLMTDKQAGKRGVGGEVLAYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZDG6</accession>
    <name>A0A1H5ZDG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine dioxygenase type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34529">
        <property type="protein sequence ID" value="SEG34529"/>
        <property type="gene ID" value="SAMN04489712_104503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG34529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15705" checksum="69EFBC4BDA69DFF0" modified="2017-01-18" version="1">MNLDVVPDITMRGQDDPHGLATGRPPTVGQLAARVHELAGRPDAWWHLVRLDPAAPGRVVLDETGGVRVWLTTWPPGHRTDVHDHGGTRVSTVIAGELTEIVIAADGVTERPLRANRIRVHGDGRTHEITNPGPAYAITLHAQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZE72</accession>
    <name>A0A1H5ZE72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phage shock protein PspC (Stress-responsive transcriptional regulator)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_104505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34571">
        <property type="protein sequence ID" value="SEG34571"/>
        <property type="gene ID" value="SAMN04489712_104505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2154" evidence="9">
        <location>
            <begin position="347"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG34571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="465" mass="47774" checksum="86DAB2B4D7024E47" modified="2017-01-18" version="1">MTAGPRAAEDYPRLVRAQDGRILAGVCTGLGRHVNVDPVVLRVGFAVLVLSGGQGLLLYLAAYLLMPSAAERPAPAEQLLKRRFDAGTVLALLGVLLCLATLTLTAGRWFSGGALAGVTVFALVLLVAHARKVDFAQVARSMPERLQGHPMEPATPFPGAATGPIFPGQTPQPDADGPVFLGKTPPPGAGGPISSEDASPSDAGGPVFLGKTPPPGAGAPLPEGMIDLAELSDRYRRGGPPQDVPAPPAGKPERGCGGHRPKPMLTSLTLLGAMAAGAAMIPVAVNGGYGPYGVSLVLAPALAVIGLGLLVGGWFGRARGLATVGTLLTFSLLTTTVVAEAPPDTKFGDVEWRPADASRTEQTYRLGAGDGKLDLTALPLAPGRRIRINAELTVGTLKITVPDAARVEIDGRVGLGDLTVEGRISGGPRAKVVEVLEPQARGTANPPVIELRVRARVGDVEVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZV17</accession>
    <name>A0A1H5ZV17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L,D-transpeptidase catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG39824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG39824">
        <property type="protein sequence ID" value="SEG39824"/>
        <property type="gene ID" value="SAMN04489712_1051"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009291979" evidence="3">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG39824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="111" mass="11549" checksum="C03102CF799966AF" modified="2017-01-18" version="1" fragment="single">RRLTLVRSGRKIGAWTVAVGAAKTPTPAGRTFLLGLLKPSDPKPSPLIMPVGAHSETLDTFGGGPGTVAFHGWADESVFGRAVTHGCVRVPDDALTRLSKVPLGTPVLITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZVF3</accession>
    <name>A0A1H5ZVF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEXXH motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40399">
        <property type="protein sequence ID" value="SEG40399"/>
        <property type="gene ID" value="SAMN04489712_10532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG40399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="35802" checksum="C6DF26837EC3AD20" modified="2017-01-18" version="1">MGALAAAAAVRAGADCSVRVPVSGGRLMLPSLGLALPGGGRSSAMVRVTAEGARITSGGARITVPADPHRDAPGWRGLRRVSAVCDGLRLDLLIDDLDPYRMPALGVRDRLTAAETQDWESDLRAAWRLLVRRHPGTAAEIRGLIRVITPLAGPARGRSSASSREVHGTIALSAAGEPRALALTLAHEVQHVKLAMLLDAVALIRPGHQRRYYAPWRDDPRPIYGLLQGAYAHLGVADFWRRERRHQPHDVEPHAEFERWRSATLLACTELLRGDGLTATGTAFVNEMARTLRDWGNEPIPPHAVRLARLRAERHRTLWSRHNGAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZYA1</accession>
    <name>A0A1H5ZYA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crotonobetainyl-CoA:carnitine CoA-transferase CaiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41439">
        <property type="protein sequence ID" value="SEG41439"/>
        <property type="gene ID" value="SAMN04489712_10579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG41439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="432" mass="46293" checksum="8690ED90D591E801" modified="2017-01-18" version="1">MSWTAPPAPAGAADGAGTGRVIIDALPRPRDQSRLTRRNALSGPLEGVLVVDLSRVLAGPHATMMLADLGARVIKVEAETGDETRQWGPPFVGEDQVSTYYLSCNRNKESIALDLKSAEGRQVLTRLVRHADVLVENFRTGVLDRLGFPVEHLHELNPGLVVLSITGFGHDGPEGGRPGYDAIMQGEAGIMSVTGPPGQPSKLGLSICDVLAGMNGAYGVVAALYERTRTGRGRVVRTSLLASTVGAHTYQGTRWTVAHDVPVSIGNDHPSIAPYGTFRCADGEIQIGVANQNLWRRFAPLVGIDPDDERYATIPDRSARRAGLTADIEKALATAPRQTWLERLAEAGVPAGSIRSIDEVYQWEQTRSQGLVIEVDHPRLGTIELPGPPLRFDGAEPREHSAPPLLGQHTDAILAWLDEADRAAGADRTASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZB0</accession>
    <name>A0A1H5ZZB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41480">
        <property type="protein sequence ID" value="SEG41480"/>
        <property type="gene ID" value="SAMN04489712_10581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="203"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG41480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="42486" checksum="DF40EE437C5D77CA" modified="2017-01-18" version="1">MTGRDVFLVCNNVDEPGGVQRWAHHLAGLLAGRGHRVTLVGVTRAGEPHGRPRDVPYAVTVLHERWRPPALGWRPGPGWSRLDVRARLRDRWRTAAMRQGAGRLSELLRAARPGGVVIAAQVWAMEWVRLADTTGLKVIGMSHESYQASRRSSRHRRVREFYADADRMLALTAEDADAWARTGMTNADHMPNPLPLSPAPRADLDARVVACLGRLSHEKGVDMALEAWAEVSAAHPGWRLHVHGSGPQEDALREQARSFGIAGTVEFRGPAADAVAALSRASVFLLPSRQEGLPMSLMEAMACGLPSVAFDCAPGVRELVTDEVDGLLVPPGHTPALAAALERLIRDGDLRREFGAGAAAAVLRFRPEPVLERWERLFALLHRDQFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2M1</accession>
    <name>A0A1H6A2M1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_105111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41996">
        <property type="protein sequence ID" value="SEG41996"/>
        <property type="gene ID" value="SAMN04489712_105111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="4">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="125"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG41996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="383" mass="40239" checksum="DCC3EBF868992AD0" modified="2017-01-18" version="1">MDAMASPVTIDQVTAALATVIDPEIRKPITELDMVKSVDIAPDGTVRVAVYLTVAGCPMRDRITKDTTEAVAKLPGVTSVQVELDVMSDEQRRALREKLRPGEVAKEIPFAKPSSLTKVYAVASGKGGVGKSSVTVNLAAALAAMGRKVGVVDADIYGHSVPRMLGVQGRPTKVEDMIMPPSAHEVKVISVGMFTAGNQPVVWRGPMLHRALQQFLADVYWGDLDILLMDLPPGTGDIAISVAQLLPAAEILVVTTPQQAAAEVAERAGAIAAQTHQQVAGVIENMAYLECGHCGERNEIFGSGGGQQVADALSRTLGTKVPLLGQVPIDTRLREGGDNGLPLVLSEPDAGAAKELRTIAESLAGRSRGLVGRSLGISPTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A3A3</accession>
    <name>A0A1H6A3A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42226">
        <property type="protein sequence ID" value="SEG42226"/>
        <property type="gene ID" value="SAMN04489712_105124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292260" evidence="2">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG42226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="17668" checksum="03DAE8275FBAF85C" modified="2017-01-18" version="1">MLVVLALAGLAVLAAVVVLAMGRGGELTEVHADHPPLRMPTGRRLTGTDVALLRLPHGIWGYQVDVTDEVLHRLAYALSERDARVAALEAQLAELHYRPARHDDPGPWDDPQPVPWEEAPAGDRHDDPDDGEPAAESAESAEPAQDDDLVGRHAGDLPGAPGKEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A513</accession>
    <name>A0A1H6A513_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43420">
        <property type="protein sequence ID" value="SEG43420"/>
        <property type="gene ID" value="SAMN04489712_105195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG43420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="517" mass="55855" checksum="FA05830E4FEDDFC4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A744</accession>
    <name>A0A1H6A744_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain-containing protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44261">
        <property type="protein sequence ID" value="SEG44261"/>
        <property type="gene ID" value="SAMN04489712_105242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="7411" checksum="D903BFCA5BDFFC00" modified="2017-01-18" version="1">MAARTQTPTRSRPGWATTDQAAQHLGVARQTLANWRSQGRGPTWSKRGGVVRYRWADLDAWMSDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AIT8</accession>
    <name>A0A1H6AIT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein N-acetyltransferase, RimJ/RimL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48431">
        <property type="protein sequence ID" value="SEG48431"/>
        <property type="gene ID" value="SAMN04489712_105475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG48431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="20648" checksum="9069A3D8ABDF7196" modified="2017-01-18" version="1">MYPVTVPGQRLVLREFTEADIDAVIAIYGDPIVTEHLSFEPRTRDQVTTTIQTVTKAARAQPRTEYSLAAALASTNEAIGFARLAIDTGHPGQSSAQLGFALRKDHWGQGLGSEMLQLLLALGFDHLGLHRLWGARSPANITSDQLMRKHGMVEEGRIRHHLRIRDQWRDSIVHSILEHERQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5H6</accession>
    <name>A0A1H6B5H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoinositide phospholipase C, Ca2+-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55457">
        <property type="protein sequence ID" value="SEG55457"/>
        <property type="gene ID" value="SAMN04489712_106233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08589">
        <property type="entry name" value="PI-PLCc_SaPLC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032075">
        <property type="entry name" value="PI-PLC-C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16670">
        <property type="entry name" value="PI-PLC-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293363" evidence="1">
        <location>
            <begin position="37"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="386" mass="41243" checksum="1CEAD8C2AA7ABC98" modified="2017-01-18" version="1">MISRPPFRGRRRPPGRAAALAAIALAAAVALPAAQAGSAAARAVEPRLNQIQVIGTHNSYHIEPGPAEFGLMSTVAGAQAGGLQYSHPPLGQQFAGQHVRQIELDLYADPDGGRYARPAIRRLTGQPPEYDPRMREPGTKVLHVAGLDYRSNCLALTDCLAAVRDWSRGNPGHVPVAILLEFKDTLDLPVPGGVSIPLVTWTRERMLGVEEEIRSVFAPADLITPDTVRRPGRTLEQSVLEGGWPTLSAARGKVMFLMDNTGVHRDRYVTGNPGLEGRTLFTSSEPGRPDAAFIKRNDPAPGIRDLVARGYLVRTRADADTAQARSGDTTTRDTALATGAQWVSTDYPVPGLAARFGTGYYAALPGFVPVRCNPVNAPAGCAVTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5K3</accession>
    <name>A0A1H6B5K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55902">
        <property type="protein sequence ID" value="SEG55902"/>
        <property type="gene ID" value="SAMN04489712_106269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG55902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="73" mass="7846" checksum="EDB9C85C7A977D50" modified="2017-01-18" version="1">MTDPNGKSHIAHASLDGPAERTLIEPWLTEYAGLMTNAYPDERPRAAAETHRLATVTALDPQPTPPARTVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BDD0</accession>
    <name>A0A1H6BDD0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purA</name>
        <name evidence="8" type="ORF">SAMN04489712_10721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58789">
        <property type="protein sequence ID" value="SEG58789"/>
        <property type="gene ID" value="SAMN04489712_10721"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="344"/>
            <end position="346"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="417"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG58789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="45752" checksum="92F5AEDB15C323D6" modified="2017-01-18" version="1">MTHRIVVDLGFGDAGKGTVVDWLCSRGHEGRGTGTGDGESTPVHAVVRFNGGAQAAHNVVAPDGRHHTFAQFGSGTLTPGVRTHLSRFMLVDPLALAAEARHLARLGVADALDRLTVDGDALLTTPYHRAAGRARETARGPARHGSCGMGIGETMAYSLAYPGDAPRVADCLSPARLRRRLAAVRDWFHDAFPGAGQPVPDVADCLDAFTAFAGRVRVVGGAHLAGLLRAGPVVFEGAQGVLLDEWHGFHPYTTWSTTTFANAETLLAEAGASAVRLGVVRAYMTRHGPGPFVTEDPALTADLPDRHNAFGPWQGAFRVGHLDLVALRYALEVSGGADALAVTHLDVSQTRRDLLLCRAYEMDGRRIVRLPSGPPGDLGGQEALTRRLLAARPVYGPLEDPVAALEAGLGVPVALRSYGPTADDKRAAVPITNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BE16</accession>
    <name>A0A1H6BE16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein LprG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LppX/LprAFG lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59018">
        <property type="protein sequence ID" value="SEG59018"/>
        <property type="gene ID" value="SAMN04489712_10741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16334">
        <property type="entry name" value="LppX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009830">
        <property type="entry name" value="LppX/LprAFG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07161">
        <property type="entry name" value="LppX_LprAFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293637" evidence="2">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG59018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="24444" checksum="51DD1C303356E21E" modified="2017-01-18" version="1">MSWIRSRMSVILVCALALAGCSGGSGGEDAGKPLPQGQQTLRQASEAMRNLKSVAFTIATEGEPAVPVKGGDVKLVRSGDAQGRLQLQQLGLTLETDFVLLGDTLYYKGLTGSGYQKAPKSRILALYDPSAVLDPERGISGMLAAARSAQPEAVEKVGGKDAYKIKVTLPKDAAGGLIPGVTQDLAGHVWIATAGHRLLKVRGQLPPASGDDGGKSAVVITFTEFDADYQITAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BEU3</accession>
    <name>A0A1H6BEU3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58766">
        <property type="protein sequence ID" value="SEG58766"/>
        <property type="gene ID" value="SAMN04489712_10719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG58766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="339" mass="38321" checksum="EFAFCFC2C3F34C7A" modified="2017-01-18" version="1">MRVRNLDDALLLLNSARTPQQLFGHGEAGRLYRRMARLLHPDATGGRTADEFVRLNTLWRAFKAGTSAITTRRHTYELGEEIARGDLANLYAATHDDNRRAVVKMPRDPGDSDLIEREAVALRRLPKDGDGRFLPYVPHLVETFRHRDLATGAQRQVNVIARLEEFRSLAEVRAAYPGGLDPRDVAWMWRRLLVALGFAHRAGVLHGAVLPEHVLIHPEQHGLVLVDWCYSVPGGRTPADPGGRVPAMVDRYADWYPEEVRRRRPASPATDISMATRCMTHLMADDAPKALRLFAKGCTLSAQNRRPSDAWRLLAELDEVLERLYGPRRFRPFHMPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BGK7</accession>
    <name>A0A1H6BGK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="17" type="ORF">SAMN04489712_10791</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59800">
        <property type="protein sequence ID" value="SEG59800"/>
        <property type="gene ID" value="SAMN04489712_10791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013173">
        <property type="entry name" value="DNA_primase_DnaG_DnaB-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08278">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00766">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="260"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SEG59800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="623" mass="68800" checksum="D6B40A7E133B1EE3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BJK5</accession>
    <name>A0A1H6BJK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60557">
        <property type="protein sequence ID" value="SEG60557"/>
        <property type="gene ID" value="SAMN04489712_107139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="15556" checksum="939CB0C86A8C34C0" modified="2017-01-18" version="1">MRPPSPGWGLARLATAAVLLVSAFLPWARASVRLEGFGQVLARELAAEAGVNVDGTGQVIPVFAVVAIVMIVWGLLARDSRIGALAAVPGLLALFSCLIFLLRLDRFREEAGAGRLMLGGLEVTAGYGWYLSVASSLLLIGLSLARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BKL3</accession>
    <name>A0A1H6BKL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycolate oxidase iron-sulfur subunit</fullName>
            <ecNumber evidence="4">1.1.99.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_107175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-lactate + A = AH2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15089"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>A + glycolate = AH2 + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:21264"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="1.1.99.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 2 [4Fe-4S] clusters.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.14" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61005">
        <property type="protein sequence ID" value="SEG61005"/>
        <property type="gene ID" value="SAMN04489712_107175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012257">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32479:SF17">
        <property type="entry name" value="PTHR32479:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000139">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG61005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="426" mass="46478" checksum="DF0E7EF8EE50D77F" modified="2017-01-18" version="1">MTSRDEELRPLVDDCVHCGFCLPTCPTYVLWGEEMDSPRGRIHLMGQHLEGEPLGLPMVEHFDRCLGCMACVTACPSGVRYDRLIEQTRAQVEREHSRPAGERAVRELIFRLFPYPRRLHALRGPLRLYQRTGLDRLVERTGVLERLSPALAAMERLAPPLGRAPRLPERVAARGGRRATVGMLTGCVQREFFPGVNAATARVLAMEGCDVVIPRGQGCCGALSVHSGRQEEGLRFARRTIAAFESVDVVVVNAAGCGSVMKEYRELLAGDPVWAARAEAFSRKTRDLAEFLVELGPRAERHPVPVTVAYHDACHLSHAQGIRVQPRALLAGIPELTVREIADPDICCGSAGTYNLLQPEAAAQLGDRKAAGVRDTGAELLVAANPGCSMQIATALRRRGEEIAVAHTAQVLDASLRGLGRGPLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BLE1</accession>
    <name>A0A1H6BLE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61541">
        <property type="protein sequence ID" value="SEG61541"/>
        <property type="gene ID" value="SAMN04489712_107222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG61541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="46064" checksum="C71C43F06D79F0E7" modified="2017-01-18" version="1">MERHRVSPVTVSRALARLAAEGLVVTRPGSGTFVAERPRPARAPRPADHGWQAVALGDRTVDPAGLTGLLTAPPEGIIPLGCGYLLASLQPLQALATAAARAARRPDAWERPPLAGIDGLRTWFARAIGGQITPADVLITDGGQHAITIALRALLPPGAPLLVESPTYQGALAVARAAGLHTVPVPVDDEGVRPDLLADAFAMTGARVFYCQPTFQNPTGAVLTGERRRQVLAVARAAGAFVVEDDFARHLGVEPAPAPLAADDPDGRVVHIASLTKASAPSLRIAALTARGPVAERLRAVQVVDSFFPSRHLQETALELVSSPAWERHRRTVRTALRDRRDALAAALARELPELRFEPPGGGMYLWVRLPDGVDETTLVEAAWREGVLVNPGRPCFPAEPDGPHLRISFGMAASEAELAEGVRRLARALATMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BN95</accession>
    <name>A0A1H6BN95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61925">
        <property type="protein sequence ID" value="SEG61925"/>
        <property type="gene ID" value="SAMN04489712_107257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG61925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="162" mass="17263" checksum="9BB93DB5AC21B722" modified="2017-01-18" version="1">MSVTDIDGARFRSVLGRFATGVVAVTAIGPGGRPAGLAANSFTSVSLDPPLVSFCVAHTSTSWPRLREAERLCVNILSRSQEEVCRRLAAKGGDKFAGLEWTLSPGGGPVLEGALAWIECAVEAEIPAGDHRIVVARVHHLDKHHDGDPLLFYRGAYGRFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNH0</accession>
    <name>A0A1H6BNH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61766">
        <property type="protein sequence ID" value="SEG61766"/>
        <property type="gene ID" value="SAMN04489712_107242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG61766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="10462" checksum="6587D0ADF6757828" modified="2017-01-18" version="1">MGALTFDLLLGDVRSLKQKRSVVRPIVAEVRRRFPAVAVAETGANDLHRRAEIGVAVVSATAGNCTEVLDACERLVAGRPEVEMLSARRRLYGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXC0</accession>
    <name>A0A1H6BXC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgk</name>
        <name evidence="12" type="ORF">SAMN04489712_10857</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64826">
        <property type="protein sequence ID" value="SEG64826"/>
        <property type="gene ID" value="SAMN04489712_10857"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="351"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG64826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="41642" checksum="740E3C6268470D28" modified="2017-01-18" version="1">MRTIDDLDVRGRRVLVRADLNVPLDGDRITDDGRIRASLPTIEALRERGARVIVCAHLGRPKGEVKTEFSLAPVARRLGELLGTDVAFASDVVGASAAETTAGLADGQVALLENLRFEPGETSKDDAERGAFADRLAALAELYVGDGFGAVHRRHASVYDVPRRLPHAAGKLIAAEVDVLRRLTEDVRRPYAVVLGGSKVSDKLGVIDNLLGKADRILIGGGMVFTFLKAQGHEVGKSLLEEDQLDTVTEYLARAEKAGVEFVLPVDIVAATAFAADAEHDVVPADAIPADRLGLDIGPASGRLFAERLAGTATIFWNGPMGVFEMEPYAHGTRAVAQALIDSGAFTVVGGGDSAAAVRTLGFDESAFSHISTGGGASLEYLEGKTLPGLSALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7P5</accession>
    <name>A0A1H6C7P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68942">
        <property type="protein sequence ID" value="SEG68942"/>
        <property type="gene ID" value="SAMN04489712_10934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG68942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="540" mass="55523" checksum="9D61E36245EE7AFF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CI85</accession>
    <name>A0A1H6CI85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72731">
        <property type="protein sequence ID" value="SEG72731"/>
        <property type="gene ID" value="SAMN04489712_11030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG72731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24462" checksum="4B52C2E0B92E791F" modified="2017-01-18" version="1">MMTERTMPAGPHGDEAGDPGQDAAGTRLLAVAGRLFAELGYDGISTQTIAAAAGVGLNVIAECYGGKSGLYIAVMEQSIGPWHQEVRAARRQGPPGAEGLIWLIDSYLDYCLEHPEMPRLWIYRWMSDATDIGGPEERISAPLMEDVMAIVRPAVAPDVDPDAALWTFVWAIHAYMQAGFLDDFGRPRRPENPQTLDRFRHHLHQLVWMMTAPDPSLREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CL57</accession>
    <name>A0A1H6CL57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_110148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73739">
        <property type="protein sequence ID" value="SEG73739"/>
        <property type="gene ID" value="SAMN04489712_110148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG73739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="33823" checksum="2CD2CD70B712D9F6" modified="2017-01-18" version="1">MRAGALSVRWEPRTAAVCAALAAVALAAAVFVLGTGDFPIPAGEVVRALAGQGDQATEFIVTELRLPRALTGLLAGLALGLSGAIFQSMSRNPLGSPDLIGFTTGAASGALLQILVLGGGTAAIATGSALGAVLTALAVYLLAYRGGGVHGQRLVLVGVGAAAMLEALNSYLITRAELREAYEAAFWLTGSLNARSWEHAVPLAVAMAVLVPAALAFGGHLRMGELGDDAAQALGVPVQRSRTALVVVGVGLVAAATTAVGPVPFVALAAPQLARRLTRRTGPHLVAAGLMGAALLVVGDLISLRLPVALPVGVVTGVLGGLYLVWLLAGAGRRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQZ6</accession>
    <name>A0A1H6CQZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75411">
        <property type="protein sequence ID" value="SEG75411"/>
        <property type="gene ID" value="SAMN04489712_11134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="79" mass="8202" checksum="4721482B6AC49C4A" modified="2017-01-18" version="1">MRAEVKGPDGMREEAGGPGESQAEMDDAADRRPGGWTMLAVTAVIALGCALSFFLGCTALGVAGLTLSGLILLFWRIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CS63</accession>
    <name>A0A1H6CS63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75503">
        <property type="protein sequence ID" value="SEG75503"/>
        <property type="gene ID" value="SAMN04489712_11147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="81" mass="8801" checksum="6053F59BEAB11B77" modified="2017-01-18" version="1">MRDPRAVGPVSRALTARREAVLREQFPGWRVREVTGQWIAARKGGPVVVRASAVELRDALRWIDQASPDPAGGDPAKVEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV98</accession>
    <name>A0A1H6CV98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76912">
        <property type="protein sequence ID" value="SEG76912"/>
        <property type="gene ID" value="SAMN04489712_111224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295254" evidence="2">
        <location>
            <begin position="36"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="37367" checksum="E20F2836F022FA8B" modified="2017-01-18" version="1">MIWLTWRQFRAAAVATAAALAALAAVLALTGPGLADDYSAGIAACTAQGSDCARFREGFFQDNQAPFFGLTAVMLALPALIGLFWGAPMITRELESGTHQLVWNQSITRTRWLAVKLALTGLAVMTTAGLASLALSWWSSPLDQAGAANDPGFPRMGPLLFDVRGIAPIGYAAFAFILGVAVGMLVRRALPAMAVTLAVFTAVQVAMPLLVRPHLRAPVHATVELSTSNLNQLGLRPDEGVDVHLRAMAPDKGGWVLSTRLIDKSGNEVHGVLPVSTASGPCALRDRRQQGPDPCLNELNRLGYRQEVSYHPADRFWAFQWTETGIYMVLTLGLTAFCFWRIRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZ82</accession>
    <name>A0A1H6CZ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78459">
        <property type="protein sequence ID" value="SEG78459"/>
        <property type="gene ID" value="SAMN04489712_11280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG78459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="29171" checksum="73D07B269A83D8D9" modified="2017-01-18" version="1">MTTSHSLTAERLTLGYGDRVVVESLDLTVPPGRVTVIVGANACGKSTLLRSLSRLLAPREGRVVLDGRQVHRMPAKELARTLGLLPQSPVAPEGITVLDLVCRGRHPHQGLFSRWNGRDDAAVAAALEATQTTDLADRAVDELSGGQRQRVWIAMALAQETDLLLLDEPTTFLDASHQIEVLDLLTDLNRTRGTTIVMVLHDLNLAARYADHLIALADGRLHACGTPAEVLTEDNVRTVFGLDSRIIEDPVSGRPLMLPIGRHHVRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D473</accession>
    <name>A0A1H6D473_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80061">
        <property type="protein sequence ID" value="SEG80061"/>
        <property type="gene ID" value="SAMN04489712_1137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="494"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="568" mass="62870" checksum="95236D22C87690D6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4F9</accession>
    <name>A0A1H6D4F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhamnulose-1-phosphate aldolase/alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80227">
        <property type="protein sequence ID" value="SEG80227"/>
        <property type="gene ID" value="SAMN04489712_11344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013454">
        <property type="entry name" value="Bifunc_RhaD/ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02632">
        <property type="entry name" value="RhaD_aldol-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="10"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="680" mass="72609" checksum="3A3CD99E18FBA3B1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D765</accession>
    <name>A0A1H6D765_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80858">
        <property type="protein sequence ID" value="SEG80858"/>
        <property type="gene ID" value="SAMN04489712_113165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="78" mass="8841" checksum="BEB378B4833F436C" modified="2017-01-18" version="1">MPKERKKLLLRLDPAVHDALVRWAGDELRSTNAQIEFLLRKALDEAGRTPRGAARMRRPGRPPKSETTPAPPETEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8I8</accession>
    <name>A0A1H6D8I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81552">
        <property type="protein sequence ID" value="SEG81552"/>
        <property type="gene ID" value="SAMN04489712_11482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="19931" checksum="7854506296E55052" modified="2017-01-18" version="1">MGKAIPVHDRCGAGPVAPDPVLLLPTHLMAELLKLARRTSAELFPTGGLRPPHVVALAWLDGHGPMSQRQVSERMRVNPADMVGVVDELERLGHVERRRDPRDRRRYALHLTDSGRRALHDWRARGERLNDTVFAPLAPHERDTLQELLLKVLVHHDPRFAPAVRHQEPDRVSRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8P2</accession>
    <name>A0A1H6D8P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_114125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81710">
        <property type="protein sequence ID" value="SEG81710"/>
        <property type="gene ID" value="SAMN04489712_114125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="626"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG81710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="736" mass="77809" checksum="C518E22E023E8D54" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DB39</accession>
    <name>A0A1H6DB39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82439">
        <property type="protein sequence ID" value="SEG82439"/>
        <property type="gene ID" value="SAMN04489712_11526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295788" evidence="2">
        <location>
            <begin position="27"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="21253" checksum="FA771EDDE33F5C6A" modified="2017-01-18" version="1">MPFPRRSSLFVVVLAGCVCVPGCGGGDPGARRAPGDPIRVPDLGRPVGRPLSKVQPALIKKIRKSCGGRICVNVVVKHVYPELGQQVEEAPGASPGYAGYCQYFGLDPAPGTLIRPDSTIYIIAGVRDPRPCGVPDTVPAKPVTPVPPEAPEPTEEPSAPVEATSPAETPQPSEDTPSGPPEETRGPGPSPDRTRESESPEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DC94</accession>
    <name>A0A1H6DC94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82859">
        <property type="protein sequence ID" value="SEG82859"/>
        <property type="gene ID" value="SAMN04489712_11597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9189" checksum="8D7B50DC6CD1D620" modified="2017-01-18" version="1">MPYVIKSVFPERVGLFTGLAMMLMSTGAAMSSDGRPLDAVELVAHRTRNDDRADAHGHLGTVGGAPGDAEQCADPRPSGFGEPHERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCF4</accession>
    <name>A0A1H6DCF4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrB</name>
        <name evidence="12" type="ORF">SAMN04489712_115158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
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        <property type="protein sequence ID" value="SEG83157.1"/>
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        <property type="gene ID" value="SAMN04489712_115158"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
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        <property type="project" value="UniProt"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_gyrase_B_C"/>
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    </dbReference>
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        <property type="entry name" value="Topo_IIA"/>
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        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
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        <property type="entry name" value="Topo_IIA_B_C"/>
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        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
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        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
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        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="424"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG83157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="649" mass="71869" checksum="BFF313130F0083B3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCI3</accession>
    <name>A0A1H6DCI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_115117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82978">
        <property type="protein sequence ID" value="SEG82978"/>
        <property type="gene ID" value="SAMN04489712_115117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="61" mass="6664" checksum="FC7F5116BCFFC89C" modified="2017-01-18" version="1">MVDMSDLGVIGDAELVEELSMLTTQTARMRARMADIMAELDRRRRAAGAGRPGGHVHGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHH7</accession>
    <name>A0A1H6DHH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84669">
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        <property type="gene ID" value="SAMN04489712_11746"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="219"/>
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        </location>
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            <end position="288"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="316"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="628" mass="65362" checksum="F5A2E4767A4BFA7E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIY8</accession>
    <name>A0A1H6DIY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TCP-1/cpn60 chaperonin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85427">
        <property type="protein sequence ID" value="SEG85427"/>
        <property type="gene ID" value="SAMN04489712_1181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG85427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="187" mass="19878" checksum="2E5931691987D0DC" modified="2017-01-18" version="1" fragment="single">MAAKMIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPWEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPMSLKRGIEAAVERVSEELSKLAKDVETKEQIASTASISAGDVQIGEMIAEAMDKVGKEGVITVEESNTFGLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLX3</accession>
    <name>A0A1H6DLX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86252">
        <property type="protein sequence ID" value="SEG86252"/>
        <property type="gene ID" value="SAMN04489712_11933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="419"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="511" mass="55236" checksum="330874F699B7E261" modified="2017-01-18" version="1">MRNFFEYADNDPARVAVVHTDGQQVTYGEMRDDANRISNFLWDRGLAPGDTLACLLPNSYQLMAVVRGATQLPLYLTPVNWHLTASEIAYILSDSGAKVLFTTDPFVELAERAAIEAGLPAEAVVVLAIAPEGSASRLTGPVAAASATTPRDRGAGNRMLYTSGTTGRPKGVRRPLRGISPVEAAGAALARARRYGADHEDGVFLGLAPMYHASPLAYADQALDVGHRVVLLERWNRERALEAIAEHGVTWLYLVPLMMQELVALPADERAALQVGSIRSIVHTAAPCPPHVKQAMIDWLGPVLVEIYGGTEGSATVITSEEWLTHIGSVGRPLPHVSLRILDEDRNEVPVGQVGTVYFKNEELAFVYLGDPEKTAASRLDGHVTLGDLGRLDEDGYLYLSDRAVDLIISGGVNIYPAEIEHALLEIPGVADACVVGRPDEKWGESVHAVVVLDRSGTHDEVAASLDAELRARIAGYKIPRSWTFVEALPRSAAGKLLRREVRESVATSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DN21</accession>
    <name>A0A1H6DN21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86618">
        <property type="protein sequence ID" value="SEG86618"/>
        <property type="gene ID" value="SAMN04489712_119127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14929" checksum="FFAC231A281FD180" modified="2017-01-18" version="1">MYEELADRFIAAITGGDLDTLRAVYTPDALIWHNGPGAGGGSEQRVEDNLRTLRWLSANLRGISYDEIRRDTLPSGFVQRHVLRGSLSDGTAIEVATCLFATVTEDGRISRIEEYADTRGTDPLHALAAAQRAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPB9</accession>
    <name>A0A1H6DPB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86395">
        <property type="protein sequence ID" value="SEG86395"/>
        <property type="gene ID" value="SAMN04489712_11971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="1">
        <location>
            <begin position="201"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="382" mass="41584" checksum="104DBE4E9A67F16F" modified="2017-01-18" version="1">MMPRTHPGTPAETAHRAGLTVLGPADLTSLPQQVRRLDLAVLTGIAAFLDAATSLHSPEPLAPEDAARQAGAAPRHAWILGHWLRALADEGWVTRCDDGAFHSLRRFRRAELVAAREDVDQARRSLGYPAELTRYLLDSLRHLPGLLRDEISAQALLFPDGDLQVAGAAYRHNIINAYLNAAAVESVHRLPRTDAATGRVLELGAGTGSLTADLLPVLARRTTEYLFTDLSPFFLHPARRRFAAHPFVRYETLGLDDDLTARYGAAAFDLVIAVNAAHNTVHAGALLERVAGLLAPGGTLLLIETCHEHHQSLVSMPFLLSARPGAPRTERLDHRAGTSRTYLTRQEWLDAFTTAGLRPLLDLPSPGHPLAAFSQLLLIAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQ35</accession>
    <name>A0A1H6DQ35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_120128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87419">
        <property type="protein sequence ID" value="SEG87419"/>
        <property type="gene ID" value="SAMN04489712_120128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="26407" checksum="767F22EFE9A39BE4" modified="2017-01-18" version="1">MGSLDGKVAIVTGAGQGVGQGIALALASEGAAIAVLGRTPAKLEATCELIAERGARGEAFACDVRDLEAVPGLVEEIAGRFGGIDILVNNAYTGAFGPLLEMSDADFHKGFHSGPFAAFAFMKACHPHMKRRGGGHIVNLVTSAMVRWDPQTYGAYAAAKQALRSLTRTAAAEWGPDGIRANSIAPHALSPGLQRWAEAFPEAAEEFRKTIPLGYIGDCEEDIGRAVVALVQPGLRYLTGATLPLDGGQAYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQW4</accession>
    <name>A0A1H6DQW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_120141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87484">
        <property type="protein sequence ID" value="SEG87484"/>
        <property type="gene ID" value="SAMN04489712_120141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="69" mass="7566" checksum="731DE55DBDBE7B60" modified="2017-01-18" version="1">MTNDPNLSRATWRKSTRSSGTGECVEVAGLPRTIAVRDSKDPDGPKLSFTPRTWEAFNAGIKSGDYDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTE5</accession>
    <name>A0A1H6DTE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88499">
        <property type="protein sequence ID" value="SEG88499"/>
        <property type="gene ID" value="SAMN04489712_12215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="45431" checksum="634349CA694265AC" modified="2017-01-18" version="1">MTIASDPAGLEPTIRYEDLDVPVSAPCARFEEFDKLREQAPAHFGTALGNEFWLITRMAEIRATYQNTDAISNRAVVPHQPDPPYKWIPEMLDPPEHTKWRKLLGPFFAPGAVDRLEPKLRQRFDEIMDDVVDRGRCDYVADVALRFPNTIFMEMMGLPISDADQFQVWQTAILHKGASAPEAAFQAMLEVNDYFAALIAERRRNPREDIVSIASTWRIDGEPVSEEDLHGLCLLLFMAGLDTVAMQLSYSMYHLAANPEDRRRVVEDPALFAPAIEEFLRYYAFVTPGRKVVKDTEIAGCPVKAGQMVWLPLVSANRDPREFPDADKVIIDRKDNRHLAFGAGPHRCLGSHLARRELTIGLTEWHRRIPDYHLDPDVEIREHGGQIGLDNLPLVWNVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTR7</accession>
    <name>A0A1H6DTR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88444">
        <property type="protein sequence ID" value="SEG88444"/>
        <property type="gene ID" value="SAMN04489712_1224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296224" evidence="1">
        <location>
            <begin position="32"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="32144" checksum="211B0FFC0573D24E" modified="2017-01-18" version="1">MTGRAIRRLAVAAMGMGSLLGLAGVAAPSQAAAVAAPVLTGLEKVQSEVMPSDVNSVSPKSALAKCPAGKKVVGGGGWTFETSTTAPERLTLTQLQPMDNVGDGHGSDGYRVTAAETAPGVSGNWWVQAYAWCADASSVPGWHINAAYDGGTTSDPQEQVEVGCDDPSRQRVVGTGAMIGGVADESQGQVVLQTARASGTGDIARAQSHEDATGYGGNHWLAVYAVCMDTPQGYEVVSDPSAQQDSETYKHAVVQCPDGRAPVNAGAGISTSAPGHVSLQKVFPGSQAEAGAVENTPTGQDWDYIVAQGICVDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DV32</accession>
    <name>A0A1H6DV32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] synthase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89128">
        <property type="protein sequence ID" value="SEG89128"/>
        <property type="gene ID" value="SAMN04489712_12326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="119"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="251"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="340" mass="36248" checksum="60FE164F0A282B8B" modified="2017-01-18" version="1">MTEGDRMVRVGVTGVAAFLPERTVTSEEVEARVARGSDGYRPLPGIVARLTGIGTRHLAADDQQASDLAVGAARRLLERRGLTPGDVDLLIFGSASQDLVEPATAHIVSAKLGTGCPVFDVTNACNSFLNAVQIAEALIQAGQYARVLVCTGEMPSRAIRWRVRDLRQFTEAFPGYTMSDGGAAALLEPVPRGGIFHRAFEADSTSWDVGTLPGGGTMHPRDPEYTYFHADGRRLRDAFLSLGTGLFDKALADTGLRWDDFAVVCVHQVAMPYLDLLRERTGIPADRLVVTLPEHGNLASATLPLQLATAQEEGRCGPGDRVALLGLAGGVSLGAVFLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVT2</accession>
    <name>A0A1H6DVT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89309">
        <property type="protein sequence ID" value="SEG89309"/>
        <property type="gene ID" value="SAMN04489712_12364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="24101" checksum="2182FD9B6F1284FB" modified="2017-01-18" version="1">MLVAGFPAGSFAANCYLVAPAAGEECVIIDPGQDAEAGIEEVVREHRLKPVAVIATHGHLDHIWSVAPVCGARNVPAYIHPADRDLLTDPGKGLGLGAGQQLFGGLELSEPDDVRELSDGAVLELAGLRFTVDHAPGHTPGSVTFRTPATEEIPEVMFTGDLLFAGSIGRTDLPGGSYEQILASLARVCLPLADETVVLPGHGEQTTIGRERAVNPFLADLTPADGPSKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVV9</accession>
    <name>A0A1H6DVV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89329">
        <property type="protein sequence ID" value="SEG89329"/>
        <property type="gene ID" value="SAMN04489712_12369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="134" mass="14000" checksum="228E4DDE1CEF1F8A" modified="2017-01-18" version="1">MRVTGMAGRVPHGVAGMLVVLFALAGVAFSYGLGGHTPPLRFCLVHAQEPGDRAPVGPGIVAQDQAHPAPGHPRPAPGDACLSLAVLLTLMVLALAAVPRPRGVRPRRFGWTLVPPARAPSRPRPLAVLQVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYL0</accession>
    <name>A0A1H6DYL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89715">
        <property type="protein sequence ID" value="SEG89715"/>
        <property type="gene ID" value="SAMN04489712_12438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="31898" checksum="2E50B9BD1B0DB402" modified="2017-01-18" version="1">MAEQGPTARQRKLAALLKRYRDEAGFIQEDAAELIGIERTKLVRIEGGRRIPTVADVEKILDAYGPADETTRRGIIRLTEQVRQRGWWAPFTDVLAGSYAELEHAADRIRMFQVQLVPGLLQTEDYARLLIAKHFPDLPEEEIDRRVQVRMTRQAMLKRKNPPRLEFILTEEVLRRPVGGRDMMRDQLGHLLAASTRPHVSVRIIPIDRGHYASIGGGNLVLFEFNSVVDLNVAYLETIVGGRYEENASQVRACSLIYDRLAESALPEDESAALIGTIMKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZU5</accession>
    <name>A0A1H6DZU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Flp pilus-assembly TadE/G-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90731">
        <property type="protein sequence ID" value="SEG90731"/>
        <property type="gene ID" value="SAMN04489712_12722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="14770" checksum="96D22687CD211C5E" modified="2017-01-18" version="1">MNARGRERGDRGTVAMYTVLLTPAVLLLAGLLVDGGLAIHARQRAADMAEQAARAGANEIDVETLRATGQPRIDQGAACASAYDLLAAYGQDIAGRGCVPGAEEVRVTVTIRVSPQLLAIVPGLGDFTMTSTASAHPETGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1A8</accession>
    <name>A0A1H6E1A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91149">
        <property type="protein sequence ID" value="SEG91149"/>
        <property type="gene ID" value="SAMN04489712_12848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="385" mass="41907" checksum="41DC603653A7BE47" modified="2017-01-18" version="1">MTLKFHWFLPTFGDGRSLVGGGHNVPRGITAPAGRPGRADRHRAPDIDYLAQIARSAEQLGFDAVLTPTGTWCEDAWLTTAALIRETSRLRFLVAFRPGLVSPTLAAQMAATFQRISGGRLLLNVVTGGEQAEQARFGDHLSHAERYARTDEFLSVVRGAWGEEPFDFTGDHYQVAGATVAGDVDPVPELYFGGSSEAAGPVAARHVDVYLTWGEPPVQVAEKIAWIRKLAAEEGRILRFGIRLHTISRDTSEEAWREADRLLKDIDPAAVATAQQTLARSDSVGQQRMLSLHEGFREGGGSTRDLEVYPNLWAGVGLVRGGAGTALVGSHTEVADRIEEYADLGITEFIMSGYPHLEEAYWFGEGVLPELQRRGSFAPGLWGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1P2</accession>
    <name>A0A1H6E1P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91457">
        <property type="protein sequence ID" value="SEG91457"/>
        <property type="gene ID" value="SAMN04489712_12923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG91457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="27678" checksum="268FA63722520CE4" modified="2017-01-18" version="1">MTTLTGRTAIVSGSGRGIGRAIALKFAAEGADVVVNDLDPAPAEETVAAVMDAGGCAVACVGSVTEAGFAERFVQTAIDTFGGLDIIVNNAGYTWDSVIQKTTDEQWDAILDVHLKAPFQILRAAQPYLRTPADHHRKVVNISSVAGLGGNAGQANYSAAKAGIVGLTKTLAKEWGRYKVNVNAVAFGLITTRLTEASADGNASIDVQGRQIRVGVNPQLLTAMETMIPLGRAGTPEEAAGSVYLLSIPESDYISGQVLVCGGGFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2R3</accession>
    <name>A0A1H6E2R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91483">
        <property type="protein sequence ID" value="SEG91483"/>
        <property type="gene ID" value="SAMN04489712_12931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="284" mass="30030" checksum="3CE9AB6562775D30" modified="2017-01-18" version="1">MTAPPIHYEPAGPAAVITLNRPEVLNAATPAMIGDLVAALNRADADDKVRAVIVTGAGRAFCAGADLSAGPDALAFGKDSPDATEAAVGFREPGGVLALRLLRCRKPVIAAINGPAVGLGVTMTLAMDVRLAADDATFAFPFTRRGMVPESASSWLLPRLVGMGRAQDWMVTGRTFDAAEALVSGLLTRLHPGPDLLPVALDLAEEIARHTAPVSVALTRLLLWKAYCDDGGPQRAHHAESLATILRGHSRDAAEGITAFHDRRPPRFPMTVSADLPAEFPWQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E586</accession>
    <name>A0A1H6E586_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized OB-fold protein, contains Zn-ribbon domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92918">
        <property type="protein sequence ID" value="SEG92918"/>
        <property type="gene ID" value="SAMN04489712_13612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="52"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15826" checksum="15F2AE65EE774BE8" modified="2017-01-18" version="1">MAPVPIADDLFTWPDDEPRLIGGRCAECGTHVFPLRAGCARCGAAAVERALLSRSGTLWTWTSQGFPPKAPFRGEFAGTDPFEPWLVGVIELPGQLRVESLITGCTQDELEFGMPMRLVTMPFRTDEDGQEIITFAFSPEGADHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E5S5</accession>
    <name>A0A1H6E5S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92549">
        <property type="protein sequence ID" value="SEG92549"/>
        <property type="gene ID" value="SAMN04489712_13431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="88" mass="10040" checksum="87CCD88A03F88AC7" modified="2017-01-18" version="1">MFEIWESGEPARFVSDAETLKGALDKVDTICRLRHDQAAADLEQPQDGYRFEIRDEDGASLAMLAYRPDPSRPYQSVIVQELLEQDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E620</accession>
    <name>A0A1H6E620_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93142">
        <property type="protein sequence ID" value="SEG93142"/>
        <property type="gene ID" value="SAMN04489712_13725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="14219" checksum="5A9CF530C32CE951" modified="2017-01-18" version="1">MSEMDELSRLLCLHGVRVTPFGEGMVAWLERSGDMVRAYVVTYDSWRGGGRRWIAWGPGRSQRCPAVEVDRAALELLACLREMPVGSPPAPWPRPSRDCRGVDGWRGRWRRLRAQARARLGSEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E793</accession>
    <name>A0A1H6E793_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93123">
        <property type="protein sequence ID" value="SEG93123"/>
        <property type="gene ID" value="SAMN04489712_13719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="632" mass="67619" checksum="FC172B804A7D493A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7D7</accession>
    <name>A0A1H6E7D7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93069">
        <property type="protein sequence ID" value="SEG93069"/>
        <property type="gene ID" value="SAMN04489712_1373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG93069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="656" mass="64571" checksum="555BFBE1EC4554D9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7W7</accession>
    <name>A0A1H6E7W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000036">
        <property type="protein sequence ID" value="SEG92945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92945">
        <property type="protein sequence ID" value="SEG92945"/>
        <property type="gene ID" value="SAMN04489712_13623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="26887" checksum="F869A496202061DA" modified="2017-01-18" version="1">MTDSTPTDPVFTGSVFTVRDLTVTYDGGPPAVSGYHVDLAPGTLTVILGRNGAGKTSTLRGITGFLAHESGSSKGRISIRGQVVKRPNPLRLSKLGVGLVADQHKVFVNMCVQDQLRLVASRKQDLEEMYDFFPRLRERRTVRAGLLSGGERQMLATALVLLRKPSVLLVDELSLGLAPGMVRELMGHLRRLADERGLTILAADQAVHASLHVADQVQVMDSGSLVASGPLDSLDIDAVLDTYLGRHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E815</accession>
    <name>A0A1H6E815_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron(II)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_14115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93872">
        <property type="protein sequence ID" value="SEG93872"/>
        <property type="gene ID" value="SAMN04489712_14115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG93872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="39417" checksum="7EC9CA9295934724" modified="2017-01-18" version="1">MSGLGVAFVLASYAPDTPAGMERATAALAHGLRGLGHRALVITARPQQRADKNVIELYSLAVRFPCDDLSLRRAIDRSARAIRAEITGILDRHRIDIVVYVDALWGFGRAMADHPARKVLAVHVIGHPEDLAPALADAEAVIAPSASVLTEAAAWGHMTEDWQVVPNGLLHEAVGGTTEMRDRLRLHGPLRILARPAENKGVLDLLETMPHGLSRPVDVVMPAAPFDIDPGVQQSIITRCTLAARPPIRLSTRPLPWDQAPGWLSRAAVVIVPSRAETFGLVAAEAMSGGTPVVARDVDNLPALIGSGTQAGGITVDHAADSAELWQAALALLEDRLTYLSTSRAAYYSSRDFRPTSIAEHFMKAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8Y2</accession>
    <name>A0A1H6E8Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H-dependent flavin oxidoreductase YrpB, nitropropane dioxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93721">
        <property type="protein sequence ID" value="SEG93721"/>
        <property type="gene ID" value="SAMN04489712_14021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="2">
        <location>
            <begin position="102"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="374" mass="39651" checksum="245978B9D302DD47" modified="2017-01-18" version="1">MTQQASTADPASGGTRPEGARHPALRTRATELFGVEYPIVQTGMGYVSDAGLTAATANAGGLGILSAGLLSYEELAQAIDTVQSLTDRPFGVNIRADQPDVVKRVDLLIRRKVKVASFALAPREDLIKRCKDGGLVVMPSTGARRHVEKVAAWGADAVIVQGGEGGGHTGQIPTSLLLPQARDAADIVVLGAGGFFDGRGLVAALAYGADGIAMGTRFLLTSDSPVAQAVKEEYLTKSVDDTVLTRQIDGVPQRVVRGRTIDQLERGSALGRLLRAVRNAVAFQKMSGTPWSDIVREGLAMKKRHDLSWSQVVMAANAPMLYRTALLDGRPDIGVMATGQVVGLIDDLPSCRELISRIVAEATEILERLEHGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAP7</accession>
    <name>A0A1H6EAP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crotonobetainyl-CoA:carnitine CoA-transferase CaiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93986">
        <property type="protein sequence ID" value="SEG93986"/>
        <property type="gene ID" value="SAMN04489712_14218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="43237" checksum="FE12902FBF2E747C" modified="2017-01-18" version="1">MSGPLAGVRVLDFSTTFSGPYCTHQLADLGAEVIKVESPGGDITRGLGTARSPGMASVYVASNRNKASLELDLKRPGSRELVRSLIERADCLVHNMRLGAARRLGLDPETALAVNPRLVHAAITGFGSDGPYAGRPAYDDTVQAASGLAWLQSLGGRDEAYMATAVADKVAGLAAAQAVIAALFWRERTGRGQAVEVPMYETVVAFTLMEQWGGRAFVPPLGPTGYARMRSAHRRPYRTADGLISVVVYHEGHWRRFLEFTGHADLLDEERFRTVEARNANIDELYALLARLLTRRTTADWLKIFDEIDVPAMPVRTLDEVLDDEHLRAVRFFQEVTHPEEGAFLAARHATRFSASPPAPPSEQAPPDRLGDGRDAVRRWLDDRPRAGREETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAX4</accession>
    <name>A0A1H6EAX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleobase:cation symporter-1, NCS1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000047">
        <property type="protein sequence ID" value="SEG94383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94383">
        <property type="protein sequence ID" value="SEG94383"/>
        <property type="gene ID" value="SAMN04489712_1475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="482" mass="51610" checksum="8A95C939C61D0F28" modified="2017-01-18" version="1">MAAEEDVTREATFGSLPVLRGERVWNFTDFTWVNVGLAIATWAFLVGGSTAALVGFREGLAAMIIGNAIGVAVMLLASVVSSQRYGVEQYTILRSVYGIGGVALLVFTVVLFTEMGWSALLGVMFGRATAQVSNEVFGTHIGPNAIVVTLLALLALAIAWVVLAKGPLTIRWFNRIVAPGLAILTFGMAVLLITETSWSELLNAPPLEPFPDERLNFALAVEFNLGVGLSWWPVMGSLARLTDKPRSGLWPGYIGLFGATLVAQVVGMAAALTLGDSDPTVWMVPLGGQWLGILALVFIGFANLTSLSSIVYSTCLALRQAGGNRLTRIRWEWLTAAFFVLPAVVSFWPNLLYDKFLVFVTWSGAFLAAIAGTVIADYFVLRRQRLQLRGLYEPGKASPYHFSGGFNVAGLVSTGLGAVVYVVLYNPQTLATKPAFDYITASVPAAIVAAVAHLVLTPLLNRRGGGYATGHVPAHRTAKETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB80</accession>
    <name>A0A1H6EB80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94521">
        <property type="protein sequence ID" value="SEG94521"/>
        <property type="gene ID" value="SAMN04489712_14813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="48" mass="5610" checksum="5C51EBCF6DBE376D" modified="2017-01-18" version="1">MPWSSRRYDHLLSGPPRNWPAPHEWEEGFDLPQANDAYAEVNPYADPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECC9</accession>
    <name>A0A1H6ECC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Menaquinone-dependent protoporphyrinogen oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000049">
        <property type="protein sequence ID" value="SEG94606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94606">
        <property type="protein sequence ID" value="SEG94606"/>
        <property type="gene ID" value="SAMN04489712_1494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="21306" checksum="67C6DDDA607493A6" modified="2017-01-18" version="1">MKAGTDAEGGGGMFVLVGYASAHGSTRSIAERIGARLAERGHRVEVADLGRVEHVDRFEAFVLGSAVHRQAWLDAAVDFVDAHRRVLTDRPVWLFSVGMPAAMRRPWRWSAGRERAVASERLLNAIRPVDHRWFGGVLLREHTSWTGDLVVRALGARYGDHRDWARIDEWADEVGRRLAAEALSGHRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECE1</accession>
    <name>A0A1H6ECE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain-containing protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94689">
        <property type="protein sequence ID" value="SEG94689"/>
        <property type="gene ID" value="SAMN04489712_1508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="61" mass="6807" checksum="687B17C0CFF8DA5E" modified="2017-01-18" version="1">MTPLMLTVPEAARALAISRSKLYELIKSGALRSVRIEGSRRIPRKALDDYIDHLLSLEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECZ5</accession>
    <name>A0A1H6ECZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000052">
        <property type="protein sequence ID" value="SEG94826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94826">
        <property type="protein sequence ID" value="SEG94826"/>
        <property type="gene ID" value="SAMN04489712_1526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296813" evidence="3">
        <location>
            <begin position="32"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="4">
        <location>
            <begin position="239"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG94826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="30744" checksum="A18A8F75273F7151" modified="2017-01-18" version="1">MRTRSKAAVAAATAPLAATLVTVWTASPAGAHGTLSDPPSRVYVCKNEGPETPQSAACRAAVATGGTQAFYDWNEVSLLDAGGRHRELIPDGKLCSAGREKYRGLDLVRTDWPAKQISPGPLTVTYHATAPHANSNFEFYITRQGWSPAQPLRWSDLVHLRTFNNQNPTTFTRWTLDIPQRTGRHVIYSIWQRVVGSAEAFYTCSDVDFGGGSTPTPTPTPTPTPTPTPTPTPSPTQPGGTWAAGTAYQAGDRVTYSGATYQCRQAHTAIAGWEPPNVPALWQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S076</accession>
    <name>A0A1H5S076_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43975">
        <property type="protein sequence ID" value="SEF43975"/>
        <property type="gene ID" value="SAMN04489712_10126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF43975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="294" mass="32501" checksum="4DFBF4FA8EEE3A89" modified="2017-01-18" version="1">MDVFEVSADVHALIEDLLPVVNPSARFEAELARVVLPVGRFEPAASTWTILERCARAEPPRWPGLVEEWLREVTDRAVLAIADIELLGDVRELLRLRIVPRLTEEQRSGLVVLPAGEHFDALVVIDHPEFGGPLTEARARLLGLRGLGRFVIPNTYERELADVQVRDQPITPGEMVRVVTKPGCRYVSALYTEVERFLPDVGEAGALLAMPVHSTILLYPVTSAAVNTVLPALAQVAAEMYAADADPCAPGVYWWRRGHPLTGLDPAAPVPVAPNDGAGDRPRPRRRRPPWRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S0H9</accession>
    <name>A0A1H5S0H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF43337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF43337">
        <property type="protein sequence ID" value="SEF43337"/>
        <property type="gene ID" value="SAMN04489712_1014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="227"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF43337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="430" mass="45974" checksum="903C197C5CBC0E20" modified="2017-01-18" version="1">MPWEEAGGGAVCQDRGVLWRLLLERLTWRRWAYLVMGGALLMPYWFLSWVVVAFLPVPADRPLRDVIALVLALALPAAGTFVTGLLPAVRVLEATAIGELVGGRLGERPVEPSPDWPTRLRTGCWFFLHTHVGVLVSALSLAVPPLALLLAAFPFIDQGDVLSSQGGYHDGLARALAPGAGLALTVALLGVIAATGLLAAGLAPAFLGPSPAERLAEAERRADRLAERNRLARELHDSVGHALSVVTLQAAAAGRVLERDPDFARRALSAIEESARSALADLDHVLGLLREEAHGRAPQATLADLDGLLDKTRLAGVRLDARVGGGLDRVPAVVSREAYRIVQEGLTNALRHAGRVPVRLRIEAGDDRLEVEMSNPLNDAAAGRPGRRTGGGRGLPGIRERVTVLRGRMRAGREGRTWRLYVSLPLRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SCX7</accession>
    <name>A0A1H5SCX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47617">
        <property type="protein sequence ID" value="SEF47617"/>
        <property type="gene ID" value="SAMN04489712_101136"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012727">
        <property type="entry name" value="Gly_oxidase_ThiO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02352">
        <property type="entry name" value="thiamin_ThiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="DAO" evidence="3">
        <location>
            <begin position="15"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF47617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="41334" checksum="E9D788136F581CE6" modified="2017-01-18" version="1">MSATARDPRRPPAWDVLIIGAGVIGLATAWRVASRGLSVTVVDPDPAGGACRVAAGMLTPVSELAYGEEPLLRLGIASRDRYASFVAELEEAAGHETGYRRDGLLQVAFDSDDLAFLDDLRRFQESLGVPVEALTGRECRRLEPMLAPSVRGGLLAPEDGSVDPRRLTGALLVACQNAGVRLVERRADALIVERDTATGVRLDDGAELRAGKVLLAAGAWSNDLKGLPDGVVPEVRPVKGQVVRLRARAPFLGRATRGLVRGSSIYLVPRADGEIVVGATQEEMGFDTTVTAGGLWQLLRDARELLPGVTELEFAEVSAGLRPGSPDNAPVLGASALPGLFLATGHFRNGVLLAPVTADAMAEMLVDGTVPEVAAPFTPDRFEPFEVEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SP54</accession>
    <name>A0A1H5SP54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_101303</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52376">
        <property type="protein sequence ID" value="SEF52376"/>
        <property type="gene ID" value="SAMN04489712_101303"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="326"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF52376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="452" mass="48634" checksum="BC541B979564F370" modified="2017-01-18" version="1">MDTAAPPRLTVIGTGYLGATHAVCMASLGFEVLGVDVDADKIAKLASGQVPFFEPGLPELLAKTLESGRLRFTTSYAEAAEFGDVHFICVGTPQMPGSDACDISYVDAAVGALAPHLTRRALVVGKSTVPVGTAARLTHTVRELAPAGEEVELAWNPEFLREGYAVDDTLRPDRLVFGVASEWARERLTAAFRPVIDAGTPVVVTDLATAELVKVAANSFLATKISYINAMAEVCEATGADVSDLAAALAHDDRIGGRFLQPGLGFGGGCLPKDIRAFAHRAEEIGVGQAVSFLREVDAINRRRRSRTVDLVRELLGGRLDGKRIACLGAAFKPNSDDIRDAPALDVARTMHGLGAYVRVYDPAALDNARRAYPELRYGSSALDVARDADVVVLLTEWAEFRQIDPEAMAKVTAHRRIVDGRHALDPEVWRAAGWEYRALGRSWPDDRRGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ST60</accession>
    <name>A0A1H5ST60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53650">
        <property type="protein sequence ID" value="SEF53650"/>
        <property type="gene ID" value="SAMN04489712_101350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="145"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF53650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="245" mass="25171" checksum="3CF385D82BC191D7" modified="2017-01-18" version="1">MHGGMSRSAYRERPAPEGFGFACLWTHERGRGDGAFVQLVVPDGCVDVVWSDGGGLLVAGPDTGPQRAVVPAGGRMAGVRFRPGLASPALGVPADAVRDGRVPLAELWGDTAEVLAERLVSAADPVGVLAEAVAGRVRGSGLRPDPCAAAMVAALARWPVREAAGRLGLGERQLRRRAVAAFGYGPKTLQRILRFQRALGLARSGVGAAEAAGAAGYADQAHLAHEVRSLAGVTFGELTGRAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SZQ6</accession>
    <name>A0A1H5SZQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/beta-phosphoglucomutase family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55398">
        <property type="protein sequence ID" value="SEF55398"/>
        <property type="gene ID" value="SAMN04489712_101406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF55398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="247" mass="26188" checksum="8D8EC378B4A1FC11" modified="2017-01-18" version="1">MLSSDLQACLFDMDGVLTDTAAVHAAAWKEMFDGFLREWSEREGIPCTPFDLAGDYVEYVDGKRREDGVRSFLASRGIRLPEGRPDGPPEAETVHGLGARKNALLLRLLDERGVGVFPDAVDFVRAVRERGMRTAVVSSSANTVQVLKAADLTDLFDARIDGVVAQERDLPGKPAPDMFLAGAEALGAQPRRAAVFEDALSGVAAGRAGGFGLVVGVDRVGGGHAAALRENGADVVVGDLGELLETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T0Z3</accession>
    <name>A0A1H5T0Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55771">
        <property type="protein sequence ID" value="SEF55771"/>
        <property type="gene ID" value="SAMN04489712_101418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF55771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="352" mass="36938" checksum="094EE81D68BBB95F" modified="2017-01-18" version="1">MAGSARVSIADLADGAVHPPLGEAGRLAEPLMAVVLDDDVPPATLERAVARAGAGDRLLVGIASGPVPARIAGLLDALDLTLTVTGEDRRCVTVADPEEELEVLRRAAARNPQAAVVLGQVLRASESLPVGAALDVESFAYSTLLDGPEFRRWVEGRGPRPLPPVAEEPVLVRRDADRLVITLNRPERRNAYGRQARDALVDALELALLDPTLDRVVLEGAGPSFCSGGDLDEFGTTPDLVTAHFVRTRGGAGRLVHRLGTRIEARVHGACVGAGIELPALAGTVVAAARTTFRLPEVAMGLIPGAGGTVGIPRRIGRWRTLYLALTGRPLDAATALAWGLVDEVLPDDSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TCI0</accession>
    <name>A0A1H5TCI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60473">
        <property type="protein sequence ID" value="SEF60473"/>
        <property type="gene ID" value="SAMN04489712_101565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF60473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="33274" checksum="2D8F2B85316E6885" modified="2017-01-18" version="1">MGGQGRPRGPAGGTAPPRWPGPTAARLLVGARLRRLREDAGVTCEDAGRAIRGSHSKISRLELGRTGVKIRDLADLLTRYGLADEAERAELFALAHHANEPPWWGRYADVVPSWFEHYLGLEQAASLVRCYEGQFVPGLLQTREYARATIRLGHPDEPPSRIERRVELRMARQALLHRPGAPRLWAVIDEAALRRRPGSAATMRAQLAHLIAMTELPHVTVQVVPFSGSGHAAVGGPITILRFAERRLPDLVYLEQLTSALYPDRPADRNHYTMVMHRLAVEAEPPEASVPILRRVLVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TED9</accession>
    <name>A0A1H5TED9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61133">
        <property type="protein sequence ID" value="SEF61133"/>
        <property type="gene ID" value="SAMN04489712_101585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="131"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="259"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF61133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="409" mass="44834" checksum="C174DC81BC962E90" modified="2017-01-18" version="1">MTSSEAVPFSLDLSEDVAEVRQWVHEFAKDVIRPAAEEWDEREETPWPIIQEAAKVGLYSLDFFATQWLEPTGLGIPVAFEELFWGDAGIALSIVGTGLAAASVAAVGTDEQTMEWVPQMFGSPGDVRLGAFCASEPDAGSDVGSIRTRAVYDEAADEWVINGTKTWATNGGIADVHVVVASVHPDLGSRGQASFIIPPNTPGLRQGQKFKKHGIRASHTAEVVLEDVRIPGRLIVGGKDRFDERIARVREGKRAKGQAALKTFETTRPSVGAMALGVGRAAYEYALQYAQEREQFGRKIGDFQAVAFKLADMKTQLDAARLLVWRAAWMARNGRDFDNAEGSMAKLFASEMSVRVTEEAIQILGGNGYTRDYPVERMHRDSKIFTIFEGTSEIQRLVIGRTVTGLPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TLL3</accession>
    <name>A0A1H5TLL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose/arabinose dehydrogenase, beta-propeller fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63001">
        <property type="protein sequence ID" value="SEF63001"/>
        <property type="gene ID" value="SAMN04489712_101646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009285179" evidence="1">
        <location>
            <begin position="26"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="77"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF63001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="685" mass="75320" checksum="15FAB37BB84C96FF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U3P8</accession>
    <name>A0A1H5U3P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68861">
        <property type="protein sequence ID" value="SEF68861"/>
        <property type="gene ID" value="SAMN04489712_101831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF68861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="16167" checksum="F810FD2AF94FAC2D" modified="2017-01-18" version="1">MRTPLGTAEAMLTAVIDKNVDGVLETFSPAADAYVFLEGPRWTNRGGDRIAEGWHAYFRSPAGITAFRWVEGPFVFESDTLAQVCGVIDYDIVGDGKAGRLRMRMTWLVRRENGEWRIVHEHGSQPLEDPYGAGDWWPEGAVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V4W8</accession>
    <name>A0A1H5V4W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF81781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF81781">
        <property type="protein sequence ID" value="SEF81781"/>
        <property type="gene ID" value="SAMN04489712_102146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="23"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="230"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF81781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="457" mass="50384" checksum="5ECAC1A57933EBC1" modified="2017-01-18" version="1">MSGVVDEPLRVALLSYRSKPHCGGQGVYLRHLSRELAALGHRVEVLSGQPYPELDSDDIVLTKIPSLDLYRDADPFRTPALAEYRDWIDVLEFAHMRTGGFPEPLTFSLRVLRELRRRRRDFDVAHDNQVLGLGNLGIERLGLPLVTSIHHPISVDRRIELEAAKGLKQRLGKHRWYGFVTMQSQVARRIGPILTVSESSKIDIVKDFKVDPRDIEILPLGVDTRIFHPRGARTPGRIVAMASADSPLKGVDVLLRAVAKLATERDVHVIVVSRPRKDGPTERLVRELALGEQVRFVSGISDEELGELLASAEIAVVPSRYEGFSLPAVEHMASGTPLVASRAGALPEVVGDAAALVEPGDVEELAATLRRLHDSPQERARLGEAGLARVLERFAWPAVARATVEHYRAAIARQNYLRLAAGAARAGADLRSPKAVARRRGALLGRPARKEQRSADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V628</accession>
    <name>A0A1H5V628_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82636">
        <property type="protein sequence ID" value="SEF82636"/>
        <property type="gene ID" value="SAMN04489712_102177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="59"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF82636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="28014" checksum="EDF801B271912671" modified="2017-01-18" version="1">MSRWTIDGTASLEFDGVVALKATLVAGSISVLASTDKPSVLIGEVSGPPLLVSHEAGMLTVTHERLLEGVLGWLRNQQARATVTVTVPPDCPVQLNLVSADAVVAGLSARTSIKSAAGDVTLDGVTGHIDANTVSGQIEAQGLDGAVEFTSVSGDLALAGGSLDRLGARTVSGRIAADVALVGDRALTVTTVSGEVALRLPESTSAEVQLSSAAGRIDTSFPGLRRQDRAVARNMTGTLGTGTGHLTVNTVSGSVTLLSRPDDDLTDARPGVEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VRV6</accession>
    <name>A0A1H5VRV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89708">
        <property type="protein sequence ID" value="SEF89708"/>
        <property type="gene ID" value="SAMN04489712_102423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="191"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF89708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="427" mass="45603" checksum="912E0E33089B3BA4" modified="2017-01-18" version="1">MSVKIAVVGAGSGYMPGVIRGLLHRAADLAGAELAFYDPDAEHLALMTRLATAMFAARGADLTVVAHTELKPALAGASYVFTTFRPGGMAARHLDESIPLRHGVVGQETAGPGGFLMACRSVPVLLEIADVADPGAWIINYTNPTNVVTDAVLRHRPGTRVIGLCDQHVGDTEMWAGLLGLPADGLEADWIGLNHATWAERVRLHGEPIDLPARLASLEIPGGGATPWRDPSRMAELAQALGFLPNSYAKYYFFHDEVVAELRAKGTTRAQDILAMLPGYYASIAAEAAKPDPDPSRERGGGEHGEFAVDVICALHRDEGRRIIVNTRNGGAISSLEDDAVVEVPAVVGRSGPVPLTMGPLPGPVRGLTRAIHEYERLAADAAVTGDRRTALQALMAHPFIRSKHTAERILDEGLAAHREHLPQFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VTR3</accession>
    <name>A0A1H5VTR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein L7/L12 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89947">
        <property type="protein sequence ID" value="SEF89947"/>
        <property type="gene ID" value="SAMN04489712_102432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="2">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF89947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="15353" checksum="A7A781FA202F602A" modified="2017-01-18" version="1">MSSTTILILVGLPVGAMMLGFIAITFAAGHAARSSVRPVKGAPGGPPSPEAFTRAQALLDRGKKIEAIKLIRDDTGMGLKEAKDYAEAMQDGRIPGPPAASPHGAGLLSERVRAFRDAGDRDSAVALVQAETGMNREEAVRFVDALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W2R7</accession>
    <name>A0A1H5W2R7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93441">
        <property type="protein sequence ID" value="SEF93441"/>
        <property type="gene ID" value="SAMN04489712_102558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF93441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12900" checksum="FEF1DDFB34347309" modified="2017-01-18" version="1">MGSDWSWLVIDCANPRSLAEFWSRVLDFKILEEDAESVALGLDEAVSPKILFLRVPEPKAGKNRLHLDLTPDDQVAEVERILALGARRVDIGQGGRSWVVLADPEGNEFCVLRGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WAQ7</accession>
    <name>A0A1H5WAQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96649">
        <property type="protein sequence ID" value="SEF96649"/>
        <property type="gene ID" value="SAMN04489712_102652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF96649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="119" mass="13103" checksum="D2250486602CCF96" modified="2017-01-18" version="1">MARVNVDGGTLVVEMEGLDKLWALKSRLEIPLENVRGATIDPGIVREPKGIRAPGTHLPGVLVAGTFHINGQRVFWDVRDPNKAVVIELADERYARLILQVDDPRATVNLIEHAKQPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WY96</accession>
    <name>A0A1H5WY96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04428">
        <property type="protein sequence ID" value="SEG04428"/>
        <property type="gene ID" value="SAMN04489712_10312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="217"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG04428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="368" mass="39237" checksum="46B0FBE4AA1DF06F" modified="2017-01-18" version="1">MRLAVTEEQEELRSTLRRFFTGKSPSGEVRRLMATAEGYDPALWEQMAGQLGLPGLAIPERYGGAGFGLRELVVVLEEMGRALVCAPFLSTAVLAAHALLASDDEEAMRKLLPGLAEGATIATLAFAEDGGRWDADGIAMTADQGHRLDGVTSFVLDGHVADLVLVLARAPGGLSLYAVDGDAPGLTRTLLPTLDQTRRLARLEFAGTPARPVGRQGAGARILARTLDVAAVALAAEQLGGAQRVLEMSVEYAKVRHQFGRPIGAFQAIKHKCADMLMEVESARSAVLYAATAADEDPAELPVVAALAKAYVSDAFFHAAAETVQIHGGIGFTWEHDAHLYLKRAKSSQLLFGDPAHHRERVAQMIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X4Q8</accession>
    <name>A0A1H5X4Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exonuclease SbcC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06256">
        <property type="protein sequence ID" value="SEG06256"/>
        <property type="gene ID" value="SAMN04489712_10371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="5"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="585"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG06256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1006" mass="108206" checksum="5506C079225328C2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XJK0</accession>
    <name>A0A1H5XJK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_103285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11941">
        <property type="protein sequence ID" value="SEG11941"/>
        <property type="gene ID" value="SAMN04489712_103285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="114"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="221"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG11941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="42751" checksum="0D422EB27FFCFEFE" modified="2017-01-18" version="1">MTDIEEYGRRARAWLETATAGLPGEPGLQQAREFMARLYDAGYSGITWPEEYGGQGLSVAEERAFQQAAKDFALPVGVFGIGLGMCGPTLLSLGTEEQKRRYIRPLLRGEEIWCQLFSEPGAGSDVASLQTRAVPDGDGWLINGQKVWTSVARQADYGLLIARTDPDAPKHRGITMFIVDMHHPGVTVRPLRDMTGESHFNEIFFDDVEVPADQVVGGVHDGWNAAVTTLLHERVSIGMGATRTERPASFAGVSRRAAERGLTADAAVRDRLVDLYLRERAFDLLNARMAQEVKAGIAPGARGSVIKLLLADLTLFGADVAAEILGPDVVAHDGADAALARALSWAPGMALGGGTNEIMRNIIGDRVLGLPREPQVDRDVPFRELRVGTQKETGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XKA8</accession>
    <name>A0A1H5XKA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Na+/H+ antiporter NhaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_103280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11777">
        <property type="protein sequence ID" value="SEG11777"/>
        <property type="gene ID" value="SAMN04489712_103280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="14"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG11777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="425" mass="45038" checksum="6774660385B07E37" modified="2017-01-18" version="1">MSAAAAIVIFAAAYALIASERIHRTAAALGGAALMLLLHVTDAEHAFFSQDSGIDWNVVFLLLGMMVIVSVLRQTGGFEYVAIWAAKRARGRPYRLMVMLVVITAVVSALLDNVTTVLLVVPVTFLVCERLALSPVPYLMAEVMASNIGGTATLVGDPPNIIIASRGGLSFNDFLVHLAPLVVGLLVVFCLLCRWLFRAAFRYDPDLAAEVMELEEREAITDRRLLVQGLAVLGLVIAAFVLHPVLHYEPSVVALLGAGLLVAATKVTTEQALAEVEWSTLVFFMGLFVMVGGLVHSGVIGRISESAAEATQGRLGLAAMLLLWGSAGISAIIDNIPYVATMSPIVAELVGDAGPDGQVLWWALALGADLGGNATAVGASANVVVLGIAARNGHPIGFWHFTKYGIVVTLVTVALCAPYLWLRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XKP6</accession>
    <name>A0A1H5XKP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_103298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; L-ascorbate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12318">
        <property type="protein sequence ID" value="SEG12318"/>
        <property type="gene ID" value="SAMN04489712_103298"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00132"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0060">Ascorbate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG12318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="441" mass="49293" checksum="75C8400CE2A3E246" modified="2017-01-18" version="1">MSPARTSGAPDRAWRNWAGNQRAVPRRALTPRTTDEVVEAVRTAAEDGLTVRMTGSGHSFTAAAVTDGLLLRPGGLTAVRSVDTASGLVTVEAGLPLHELNRILDEHGLALANMGDIQQQTVAGALQTGTHGTGRDHAGLASQVAALELVLADGSVVTCSRTERPELFDAARVSLGALGVVTAVTWRTVPAFRLHAREEPMRWEEVLDRLDELADANEHFEFYWFPHTEGCLTKRNNRTDRAAAPLPRARHWLDDEFLSNSVFGGLQRLTRRLPAAIGPVNAVSARALGARTYIDTSYKVFTSPRRVRFKEQEYAIPREELVPTLRELRALFDRRDWRISFPIEVRLLPPEDAWLSMAHDRPSAFIAVHVYNRNPHEDYFTGVEELMTSVGGRPHWGKLHTRDAAYLEKVYPRLGAFRALRDELDPRRRFANRYTRQVFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XWL9</accession>
    <name>A0A1H5XWL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEXXH motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16164">
        <property type="protein sequence ID" value="SEG16164"/>
        <property type="gene ID" value="SAMN04489712_103445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG16164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="445" mass="48618" checksum="73A133249B30934C" modified="2017-01-18" version="1">MSLGRHSVPEKAFLALAAGSGGADALEHLKAAQRSKHLLLIRAVRDTALEAGHPEAHQAGQAYRLLADIERTHPDQVRTVLAYPTVGAWARRTLLALTGDGNARKAAHPGELTALAAAAAIRAGHSCAVEVPVRDGAVVLPSLGRAPLPGQSTALVRSRPGRAEVTAGGTTVRVPGDHHEDGPGWEALRRLSAEWRGTRVDFLLDDHDPDRAPGADPVGTRLDARELEHWRETLGRAWRMLLSRHWTTAEEVAASITVLTPLVPPEQGQSSATPKHAFGNVGLSTPPDAHFFAVTLAHEVQHTKLTALLDVVRLVRPDDGSRYYAPWREDPRPPEGLLQGAYAHLGITGFWRRQRDHESGDRALRAHSDFARWREATELGARTLLASGRLTPAGKVFVTEMRRTLRPWLREPVSAPARERARRVAEDHLSRWRLRNGEPPLPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YN23</accession>
    <name>A0A1H5YN23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureG</name>
        <name evidence="7" type="ORF">SAMN04489712_10480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24975">
        <property type="protein sequence ID" value="SEG24975"/>
        <property type="gene ID" value="SAMN04489712_10480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="6">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG24975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="24195" checksum="B115BDEFCDF22644" modified="2017-01-18" version="1">MHLHHPETAPTDIAPSGAVAVRPGAPSRALRIGLGGPVGSGKTATVAALCRRLRDTLSLAVVTNDIYTREDAEALLREAVLPPERIAAVETGACPHTAIRDDISANLEAVEDLQDRLGPLDLILIESGGDNLTATFSRGLVDHQIFLIDVAGGDDIPRKGGPGVTTADLLVVNKTDLAPYVGADLGAMERDAKTARGSLPVILTSVKADGGVEPVAAWVRRRLAEWAETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YSW5</accession>
    <name>A0A1H5YSW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27329">
        <property type="protein sequence ID" value="SEG27329"/>
        <property type="gene ID" value="SAMN04489712_104172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="120"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="530" mass="56504" checksum="61B0BEA982E31F68" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YTF0</accession>
    <name>A0A1H5YTF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26992">
        <property type="protein sequence ID" value="SEG26992"/>
        <property type="gene ID" value="SAMN04489712_104158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="16243" checksum="61A1A88A64EEFFA2" modified="2017-01-18" version="1">MQHKPPAEEQLKGSKPSRTRFAFYGRQAFNGPSYPRQLGRAWTLLKPCGADIAAVFFDIDTSPSIHWSDCAQACELIDMLTRREHTFHAVVFGLSHKEAHALFDPDFPLFRIPLWMPVFEPPQRLGGTHGPVIGSAVDDEQAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YWG0</accession>
    <name>A0A1H5YWG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysS</name>
        <name evidence="9" type="ORF">SAMN04489712_104218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28354">
        <property type="protein sequence ID" value="SEG28354"/>
        <property type="gene ID" value="SAMN04489712_104218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="180"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG28354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="498" mass="56258" checksum="CFB70B3C0302C4CF" modified="2017-01-18" version="1">MSEQQQDYDDLPEQMRVRREKLDRLREAGIDPYPVNFPRTDTLAEVRERHPGLEPGAETGERVGVAGRVMLLRNTGKLCFATIRDGSGEIQVMLSLAKVGEDALAAWKRDVDLGDHIGVQGEVVSSRRGELSIMADSYAITAKCLRPLPDKHAGLTDPEARVRLRYVDLIVNDEARRMARLRSDTVRAVRDFWHEEGYLEVETPMLQPIHGGAAARPFVTHINAYDMDLYLRIAIELYLKRLVVGGIDKVFEINRNFRNEGADSTHNPEFTMLEAYGTYLDYHDMATLTQRMYQRAVVAALGTTVVHHDGQEVDLGLPEWPRITLYGAVSQALGEEITPHTPIDQVRKHADARDIPWDPKWGQGRIVQEIFEELVEHTLVQPTFVMDYPLETSPLTRQHRDEPLLTEKWDLIGFGTELGTAYSELVDPIEQRRRLTEQSLLAAGGDPEAMQLDEDFLRALEYAMPPTGGVGVGIDRMIMAFTGKGIRETILFPLVRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z1J2</accession>
    <name>A0A1H5Z1J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29517">
        <property type="protein sequence ID" value="SEG29517"/>
        <property type="gene ID" value="SAMN04489712_104271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG29517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="32669" checksum="05CA6A9F184D9C23" modified="2017-01-18" version="1">MLDLDRLRALHAVATHGSVSAAAEALHVTTSAVSQQLAKLERETGQKLLERNGRGVRLTDAAHLLVTHAEGILSLVERAEADLEAHRGVVVGELSVAAFPTAIRGLIPAALASLRAAHPELRVLIREYDPSVSLPLVTRGDVDLAIVQDWNNEPIPVLEGLVKGAICEDVADVALPAGHPLAHREVVDLKELAGDRWISSTPGSICCDWLTHTLRSFDSEPRIDHMAYEFATQLALVAAGLGNIILPRLGRCDVPEGVRIVSLRHSLSRRVYAVWREEAARRPAICAALDALRVSARPAVAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZCI2</accession>
    <name>A0A1H5ZCI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33760">
        <property type="protein sequence ID" value="SEG33760"/>
        <property type="gene ID" value="SAMN04489712_104469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG33760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="17688" checksum="B5D9D3381153F64A" modified="2017-01-18" version="1">MTAALRAMTAADVPAVMALENETFPEDAWSEQMLRDELAGQPHARHYVVAEEPSGTIVGYAGLAAAGGQGDVQTIAVRADRQGRGVGAALLTELLAEAARRGCAEVFLEVRADNDRARALYERFGFERIGVRKCYYQPSGMDAIVMRCQARESGPAGFVRGNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZFM8</accession>
    <name>A0A1H5ZFM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ORF">SAMN04489712_104519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34854">
        <property type="protein sequence ID" value="SEG34854"/>
        <property type="gene ID" value="SAMN04489712_104519"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG34854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="41542" checksum="48F0913707FE1133" modified="2017-01-18" version="1">MDLFEHQAKELFAEYGVPVPTGKVAHTPQEARAIAEELFAAGSKKVVVKAQVKTGGRGKAGGVKLADDADEAQALAEQILGMDIKGHTVHKVLVEAGSAIAQEYYFSFLLDRANRTFLSICSAEGGMDIEEVAATNPEAVAKVPVAALTGVDRARAREIAQAGKLPEQALEGAAELIERLWAVFTDEDATLVEVNPMILTADGRVMALDGKVTLDDNAAFRQPEHAALTDEKTTDPLEARAKDKDLNYVKLEGSVGIIGNGAGLVMSTLDVVAYAGEEYGGQKPANFLDIGGGASAEVMANGLEIVLSDPSVKSVFVNVFGGITACDAVANGIVAAYKLLADRGESVDRPLVVRLDGNNAELGRQILDEAKLTGVERVDTMDEAAKRAAELAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZHE3</accession>
    <name>A0A1H5ZHE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35662">
        <property type="protein sequence ID" value="SEG35662"/>
        <property type="gene ID" value="SAMN04489712_104555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG35662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="14635" checksum="6A452FE71669753F" modified="2017-01-18" version="1">MTEIDWARLRTAAREAMQRAYAPYSGFPVGAAALVDDGRTITGCNVENASYGLGLCAECSLVSALYGPEKPAGQDRPRLVALSVVDGNGDPVMPCGRCRQLLWEHGGPGLLLETARGVVPMTEVLPDAFGAEDLDRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZYR8</accession>
    <name>A0A1H5ZYR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl diphosphate synthase, type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40935">
        <property type="protein sequence ID" value="SEG40935"/>
        <property type="gene ID" value="SAMN04489712_10557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG40935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="34818" checksum="2E69BBD741AFF9AF" modified="2017-01-18" version="1">MTTVPISMLDVRAQIDGAMRAAVGRLDPRTHRVAAYHLGWADAAGRPADAGGKSLRPALALLSARAAGADPEVGVPGAVAVELTHAFSLLHDDIMDGDRTRRHRPAAWTVFGEPAAILTGDALAALAGELLLEVPGPGGPRAARSLAAATRRLIAGQALDLGFEERDQVGLRECLTMSADKTASLLACSCSIGAVLAGAPEPLVAGLAAFGAELGLAFQLVDDLLGVWGEPAVTGKPALSDLRSRKKTLPVVAALTAGTAESARLAELYARPSPLSDAELREAARLVEAAGGRGWAEAEAGRRVERAAAHLADADLPDLVRTEFLDIAAFVTRRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2C7</accession>
    <name>A0A1H6A2C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42205">
        <property type="protein sequence ID" value="SEG42205"/>
        <property type="gene ID" value="SAMN04489712_105123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG42205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="16594" checksum="88B4DA7CC61B4541" modified="2017-01-18" version="1">MSTVSVSADVSSCVPADRVFEVLTDWPRHAEWMPFTRAEGGHEVGASVRGWTGVGPVGFLDTMVITEWVPGRRVAVRHTGRLVRGEAWFETGPLPGGGSTVLWAERLDLPLGPLGRAGWLLVGPPVRWFMRLGLRRLVRLAGAGGGASRSGAGGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A348</accession>
    <name>A0A1H6A348_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43149">
        <property type="protein sequence ID" value="SEG43149"/>
        <property type="gene ID" value="SAMN04489712_105181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG43149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="28308" checksum="D665186335937C21" modified="2017-01-18" version="1">MRRPRLTARPAKGRPPGPRKIPAPPALRRGRLAGGLGALALSAGLLAAPATAAHAESAYQPGPADFDDCPQLPPGVLPALWHCLAITVVGGRMTLGSLEQELTQPVQITVAMGPKDRKLTLLEGGIKSDPIPVNPLPLPVDLLGMTVEVRQAGPIVPAPILPASIPLKIKVNQLLVGGNCYIGSDAEPIAVKPNLGELALGSIGGVPVITTRITDDTFAVPAVTTCGLLGNPAINLIAGLPSAAGKNSATMDVAIRVKNYRLGVITGPYARDNAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A372</accession>
    <name>A0A1H6A372_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized membrane protein YjfL, UPF0719 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_105142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0719 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42505">
        <property type="protein sequence ID" value="SEG42505"/>
        <property type="gene ID" value="SAMN04489712_105142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007140">
        <property type="entry name" value="DUF350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03994">
        <property type="entry name" value="DUF350"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG42505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="14627" checksum="E11C2D4BD124F38E" modified="2017-01-18" version="1">MLNDIIEEGGAALAYGAVGVALLALGFLVVEVTTPGKLGRQIWTEGNRGAALILAAKLVGVGAIITTAIATSEDGLADGLVSTAVYGVLGIIVMTLAFYLLDVLTPGSLGAIVVGHEGETPSGQMAPACWVVAATDLAIAAIVAAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A3U7</accession>
    <name>A0A1H6A3U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine phosphatase RsbU, regulator of sigma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43032">
        <property type="protein sequence ID" value="SEG43032"/>
        <property type="gene ID" value="SAMN04489712_105174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG43032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="43445" checksum="DD31D9420888DCBE" modified="2017-01-18" version="1">MSTTSDHTTTAVPGIDGRLRLLLIEDDPGDAFLVEELLADSGLDVEILHARTLGEARRRMSARIHCVLADMSLPDAGGLDLLREVLSLTERAAVVVLTGLADAHLGVRAVALGAEDYLVKGEVDGPLLARAIRYAIERKRAEESERRLVEARIVGRENARLERGLLPVPLIDDASLHHHARYRPGRRRALLGGDFYDTVQTADGAVHLMIGDVCGHGPDEAALGVCMRMAWRTLVLAGHTGGHLLATLNTVLGHERRSDELFTTVCTLTVDPSRRTARMHLAGHPPPLLLAGDEVIAGPEEPAGPALGLPTELVDQSAWPAAEIELTDAWGLLLYTDGLIEGRIGQGSARLGTEGLVALAREARRTGVAGGALIDALVAEVESLNGEELTDDVAVLLLSNQEQERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A5Y5</accession>
    <name>A0A1H6A5Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44159">
        <property type="protein sequence ID" value="SEG44159"/>
        <property type="gene ID" value="SAMN04489712_105236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="29536" checksum="B4922DC35567D9FF" modified="2017-01-18" version="1">MTKSPRRLKQQVQDTVGEQVRDLPLHAVRLAMFGVGRALLLSDRVTRDYKEMRENGVGPVLNRLRDDAQHAAVKVAGRVADLVRGGEEAAEPPVATPPRPRPASSEISVGKPTARPAPKPAPKPAAKAAPEPVAKPAPEPTAKAAPKPAPAPSPKPAAQARPVPEPAATAETKAEPERKPEPKAEPEPKVEAKPTAEPEPKPEPEARPAGKAETKAADLPVPDYDTATLPQLRARLRGLTADQVKLLREYERRHAARAEVLRMYENRIAKLNGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AD38</accession>
    <name>A0A1H6AD38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SAMN04489712_105334</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45955">
        <property type="protein sequence ID" value="SEG45955"/>
        <property type="gene ID" value="SAMN04489712_105334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292597" description="Aminopeptidase N" evidence="12">
        <location>
            <begin position="36"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="14">
        <location>
            <begin position="130"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="385"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEG45955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="536" mass="58655" checksum="50B8EE100C335C49" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AE09</accession>
    <name>A0A1H6AE09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46404">
        <property type="protein sequence ID" value="SEG46404"/>
        <property type="gene ID" value="SAMN04489712_105362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="121" mass="13466" checksum="F6164DC6EBC43FE8" modified="2017-01-18" version="1">MKQLDLYEEYRRAVDFFEAKDYAGASRILAPIAEREPGNRAVTELLGRAHFHSASLGRAERAFRRLVELDPADGWAYEALARTLERAGRPDEAGRHRRLARALGAESSAEIEVSVTAADLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AE42</accession>
    <name>A0A1H6AE42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Undecaprenyl-phosphate galactose phosphotransferase, WbaP/exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_105397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47049">
        <property type="protein sequence ID" value="SEG47049"/>
        <property type="gene ID" value="SAMN04489712_105397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="298"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG47049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="491" mass="54659" checksum="346352137484A2D5" modified="2017-01-18" version="1">MAIVDEVGVERSQDAARHRDDPTAWIPRYLYQALALDFLAMLVAGAVAFVMRFSLVPAEYTIPYVGLAAALPLLWVATLSIGRAYEPRFIGVGWEEFHRVLRSGVVMIAIVATVAYATKTEIARGYVVLALPLGTLLTWVLRYRLRKRLHRRRWHGECMRRVVVAGHRGAVSDLVKLLEKHRYHGMDIVAVCLPPALSWGENAVDHVEGVPVLGDFGRIAEVVATVDADSVAVLACPEMDGAALRRLAWQLEADDVELVVAPALMDVVGPRISIRPVAGLPLLHVEHPELSGGRRLVKSLSDKVGALAALLALSPLLLAVTLAIRIFDGGPVLFRQTRVGRDGREFTMVKFRTMVSDAEARKAELAAHNEHDGVLFKMRQDPRVTRVGRVLRRYSLDELPQLLNVLRGDMSLVGPRPPLPEEVERYGDDVRRRLVVKPGMTGLWQVSGRSDLSWEESVRIDLRYVENWSLVLDFQIIWKTWSAVLRGAGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AVP3</accession>
    <name>A0A1H6AVP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Glutamine synthetase</fullName>
            <ecNumber evidence="4">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_1068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52125">
        <property type="protein sequence ID" value="SEG52125"/>
        <property type="gene ID" value="SAMN04489712_1068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="83"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG52125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="36936" checksum="6454B4001E21E0C6" modified="2017-01-18" version="1">MTYKAEYIWIDGTQPTAMLRSKTKILADGAELPTWGFDGSSTNQAPGKNSDCVLKPVFSCPDPIRGGDHRLVLCEVYLPDGTPHATNSRARLLPVAERFADQQSLFGIEQEYTFFQAGRPLGFPETGFPAPQGPYYCGVGADEVFGREIVERHLDACLAAGLPISGINAEVMPGQWEFQVGPAGPVEVSDALWIARWLLYRIAEEYNVAATLDPKPAKGDWNGAGAHTNFSTKAMREAYAPIITAAEALGDRVKEHISVYGYGIEERLTGQHETAPWSEYSYGVADRGASVRIPWQVEVDQKGYLEDRRPNANCDPYEVTRALVDTCCTALEKAGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXV3</accession>
    <name>A0A1H6AXV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIGR02679 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52887">
        <property type="protein sequence ID" value="SEG52887"/>
        <property type="gene ID" value="SAMN04489712_10660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024466">
        <property type="entry name" value="CHP02679_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024465">
        <property type="entry name" value="DUF2399"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09664">
        <property type="entry name" value="DUF2399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11796">
        <property type="entry name" value="DUF3323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3323" evidence="3">
        <location>
            <begin position="51"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2399" evidence="2">
        <location>
            <begin position="261"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG52887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="41924" checksum="500157AA9722D074" modified="2017-01-18" version="1">MRHETPESTEDEPAPPTELPASLASWARLPGPAKVIEAIRERAARGHSTDKGTLRLNLDADERRQVARLVGNSWNVSGRPVRLQDLSAALDGVSPLQLAELACGPVTVRAKARAERAARHTARAASVRAALESAGVAAHHAETWQSENPRAVELGEKVARVWHALSGEPIHLTRLATEVCGNAHALDGDQALGRAVARLAAVVHDLERPQRAGPTWRTAWRAVGVLCNEVSSRVLVLNLPLAGSAPAVALTAAAPGEPVWLTLRSLTGRWRPTSPQPVYVCENPTIVEAAADRHGARCAPLVCTDGVAAAAAMTLIGALASAGCTVHARADFDRVGLGIVDRLRTVAPSLQPWRFDLTSYRAAGGTTAIGDLAAAAAAHPVHEEALLPVLLDDLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B4M3</accession>
    <name>A0A1H6B4M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55562">
        <property type="protein sequence ID" value="SEG55562"/>
        <property type="gene ID" value="SAMN04489712_106240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG55562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="100" mass="10722" checksum="3FD162B35CBE254A" modified="2017-01-18" version="1">MASDYRVGCLEDLGQAVGSQGLVAKVVQTRSGPTFLRVVNPEAGSLAEDVTCAPAPGTPEHYYWWSWGERMHRVDDPGGAASKLAHVLQPLPHEAHGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B4U0</accession>
    <name>A0A1H6B4U0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mg-protoporphyrin IX chelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_106264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55848">
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        <property type="gene ID" value="SAMN04489712_106264"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01451">
        <property type="entry name" value="vWA_Magnesium_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012804">
        <property type="entry name" value="Cob_chelat_sub_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02442">
        <property type="entry name" value="Cob-chelat-sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="520"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG55848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="698" mass="72767" checksum="8697A95BABA0A2EC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B651</accession>
    <name>A0A1H6B651_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56331">
        <property type="protein sequence ID" value="SEG56331"/>
        <property type="gene ID" value="SAMN04489712_106304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG56331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="77" mass="8157" checksum="B1D7BB7E14D0F3E9" modified="2017-01-18" version="1">MTITVDHVRQLFASDEPGATLVIVAGRPQITSNPAEDDGLVVAGREDLMRGRDTPPGEDELNRLAETLNATVSELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BF10</accession>
    <name>A0A1H6BF10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59353">
        <property type="protein sequence ID" value="SEG59353"/>
        <property type="gene ID" value="SAMN04489712_10763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG59353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="21666" checksum="7D6EBB18D56AA8EE" modified="2017-01-18" version="1">MTIAFLVTTLVVVATPGTGVVYTLAEALAHGRRAGVVAAVGCTLGIVPHIMATITGVAALLHTSALAFQVLKYLGVAYLLYMAWATLRDRDAIVVETRTGPRPAARVIASSVLINLLNPKLTLFFFAFLPQFVPAGEPGSLWRMLELSAVFMALTFVVFAGYGVLAASVRSQVTSRPRVMTWLRRIFAGSFVGLGAKLALTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BK09</accession>
    <name>A0A1H6BK09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60755">
        <property type="protein sequence ID" value="SEG60755"/>
        <property type="gene ID" value="SAMN04489712_107154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036170">
        <property type="entry name" value="Prob_YezG_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160424">
        <property type="entry name" value="SSF160424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG60755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="152" mass="16872" checksum="CD54CBF4EDCFC9F2" modified="2017-01-18" version="1">MTHPDQVLRSPRERKVVESAVRALSAVAPPGWRRLSFAFYATVGIDSASLETVCMDGSTRSLVPPGRAIKHMDELRAATYRADKGAWFTARLVVERSGRYSVEFDYEGEPDFTPPLTASAYALDLDRFPRSSEHIPGWLKDKLREATGEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BK85</accession>
    <name>A0A1H6BK85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-terminal domain of (Some) glycogen debranching enzymes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60865">
        <property type="protein sequence ID" value="SEG60865"/>
        <property type="gene ID" value="SAMN04489712_107163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG60865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="77" mass="8321" checksum="61179CEAA19ED2B8" modified="2017-01-18" version="1">MREDLALRNMSHESAGCPVTLLVDADFADLFEAKEDRDQGLPQRRGGGDGLRIWADGGKETRGVRGTVEHATVGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BMX5</accession>
    <name>A0A1H6BMX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61556">
        <property type="protein sequence ID" value="SEG61556"/>
        <property type="gene ID" value="SAMN04489712_107223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="140"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG61556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="188" mass="19598" checksum="6B7EE07D29FBC062" modified="2017-01-18" version="1">MPCHYDGGVTGSDAALLLRDFVNTLDMDSSTDALAAPDGLGRWLAEHGLPASGSPAPGEEELAIAVALREGLRAAMLGHHGSGAEDVPAQLQDVLALLPLRVALTPAGPALVPACGGALGALAGLAAAITDAAADGSWRRLKVCPQDTCRWAFLDTSKNRSRTWCSMRVCGNRTKTRAYRARRRSGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BVI7</accession>
    <name>A0A1H6BVI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64673">
        <property type="protein sequence ID" value="SEG64673"/>
        <property type="gene ID" value="SAMN04489712_10845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG64673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="17270" checksum="6202641ED27A0FFF" modified="2017-01-18" version="1">MLTRGLTRRLTRGLTGGEPAEGPQDSPAELLRAGGQDAAIAGVILTLVLVAVMARLLAGPGMGPLGVPVLLGMTGTFLTSATFAVRTRLTLLRALGEVRARIGAPLDPGVPWLPTGSHAAIGEQEMRRELRRLVGAAYRCHDLSLNALVWALATIPLLVVWLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BWH2</accession>
    <name>A0A1H6BWH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65030">
        <property type="protein sequence ID" value="SEG65030"/>
        <property type="gene ID" value="SAMN04489712_10872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="228"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG65030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="471" mass="51601" checksum="27E348013E4BAC50" modified="2017-01-18" version="1">MIRELLRLHIHDEEDLFAFRQAGREAADAVGLDGPDRARVAAAISELGREAYAEHGPVEAVFWIRRVQRPALVVEVGFRREERPALAEAMAVAARLMDEVEEETRGDRVIVRVRKHLPEDAPVPGDARVRAVQERLARLVPASAQEELRRQNEELIEALEDLRRKHEELRELHAELEETNHGVVAMYNQLTQEMEETNQGVVALYAELDDKSEQLRRASESKNRFWANISHELRTPINSMIGLARLLLDTRADPLSAEQRHQIGLIAHSGQTILALVDELLDMAKAEEGRLSLRPVPVDVPALLEHLRSLLEPMAEQAGLRLVVEGATGPSDAPVTDEVMLTRILRNLLANGLKFTRRGEVRLAARTEDGHVVFTVADTGVGIAPEEQERVFEEFYQVPGSGGGGTGLGLPYARRLAEALGGGLTLHSALGEGTTVTVRIPLSPGGEPGPRRPPGAGRAGTADGTGQEGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXD9</accession>
    <name>A0A1H6BXD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_10859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64846">
        <property type="protein sequence ID" value="SEG64846"/>
        <property type="gene ID" value="SAMN04489712_10859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG64846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="8154" checksum="EEFEAFB7F047B593" modified="2017-01-18" version="1">MILATAIVLIVTSLLMILLVLMHKGKGGGLSDMFGGGISSSLGGSSVVERNLDRLTIGTGIIWFASIVVLGLLLKSNGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BY12</accession>
    <name>A0A1H6BY12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen fixation protein NifU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65325">
        <property type="protein sequence ID" value="SEG65325"/>
        <property type="gene ID" value="SAMN04489712_10895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16508" checksum="06A0BA0775C4E013" modified="2017-01-18" version="1">MQLESMYQEIILDHYRNPHHKGLREPYEAEVHHVNPTCGDEVTLRVHLEGAGDDARVADVSYDSMGCSISQASASVMSDLVIGRSVKEAMVIGDEFLALMQSRGQAEPDEDVLEDAVAFAGVSKYPARVKCALLAWMAWKDATARALGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2D5</accession>
    <name>A0A1H6C2D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family mycofactocin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67170">
        <property type="protein sequence ID" value="SEG67170"/>
        <property type="gene ID" value="SAMN04489712_108260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030981">
        <property type="entry name" value="SDR_subfam_2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04504">
        <property type="entry name" value="SDR_subfam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG67170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="266" mass="26328" checksum="1D2ED5CA5386B478" modified="2017-01-18" version="1">MTGAQRPVAVVTGAARGIGAAVSAALAAAGYDLVLGDVPAPGAVAGLRYRLATADDLTAVEKRCRDLGAQVTALPCDVRSPSDVARLVGAAGPGDLVAAVAVAGIIGADGPAWEQTPADLDRDLSVNLHGVANLARAAVPRLLLAPRGRGRFVAVVSSAGERGLPRLASYVAAKHAALGYVRALAADLGPSGVTANAVLPGSTATALLDHTAGVYGLDGAAELARHQRLARLLDPAEIASAVVWLCSEGASATTGAALNVDGGFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8M5</accession>
    <name>A0A1H6C8M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-methylfumaryl-CoA isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69330">
        <property type="protein sequence ID" value="SEG69330"/>
        <property type="gene ID" value="SAMN04489712_10973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="414" mass="44304" checksum="9107AC961E737975" modified="2017-01-18" version="1">MAGEESPGGLPLAGMRVIELSSFVAAPLGGMTLAQLGADVIRIDQIGGGPDIDRWPLAPSGRSLYWAGLNKGKRSVTVDLRSPEGRRVVADLVAESGFVLTNAAPRDGLAYEQLRERRPDLVHVRLLGLRGGGNAVDYTVNVSTGFPYVTGPEDHAGPVNHVLPVWDVACGLYLAVGLLAAERRRLRTGEGQRIEVALSDIALATAGNLGYLAEAQLCAEPRRRIGNDLFGDFGRDFATGDGRRVMMVVLSARHWRDLVAATGLGEVTAALERALGVDFREAGDRYTHRETLAGILTPWFAGRTCAEIEEAFKGTSVLWSRYRSFSDLAADGAATLRAEPLMGELTQPGIGRHLAPGSPLLLGGTQRSPSPAPLLGQHTDEVLRELLSLPDDELNDLRTRGVVGEQASGVRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C9F1</accession>
    <name>A0A1H6C9F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase family M48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_10993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69532">
        <property type="protein sequence ID" value="SEG69532"/>
        <property type="gene ID" value="SAMN04489712_10993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG69532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="291" mass="30776" checksum="45E6D76022A1440A" modified="2017-01-18" version="1">MNWFTFLPLVVTLALGTAAGRVVLPLHPAWEARLLGTVAASTTTAVAGTLLFVAINYGASLRPQWADRLPEWTLIGDDTPIPATLGIPATVLTAVGLAITVRLAAGWAEEIRQARRAAERLPDTDVPIALAIPGRRGGVLVSRGLLTELTSPELRVVFEHEGSHLRHRHHRYLAAGALAAGLLPPLRRLDERLRLAVERWADEDAAEAVGDRVLVARTVARVALARSQGWGAVPGFAESGVVQRVEALLAAPPAKSTFTGPVLLAGMGLPSTVLALTALQLDHALALALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAQ8</accession>
    <name>A0A1H6CAQ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70060">
        <property type="protein sequence ID" value="SEG70060"/>
        <property type="gene ID" value="SAMN04489712_109138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG70060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="67" mass="7383" checksum="593E029E8AE0DE20" modified="2017-01-18" version="1">MITPPNVVWRKSRRSDNGGQNCVEIASAEQAVVVRDSKDPEGGILAFRQSEWSAFAQRIKGGCYDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCL4</accession>
    <name>A0A1H6CCL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70375">
        <property type="protein sequence ID" value="SEG70375"/>
        <property type="gene ID" value="SAMN04489712_109165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046214">
        <property type="entry name" value="DUF6247"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19760">
        <property type="entry name" value="DUF6247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="110" mass="12355" checksum="94D404BFE7E4C4FC" modified="2017-01-18" version="1">MTSRPQDIALGRTPEPDKSLGAIRAALVVSEDREAFDAGLRAVLDEVRVGLDLGMLNDFVHRWWISACDSVGDPEGRRRMHARARQILAEGAAHQGRPWREVLAERESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJ19</accession>
    <name>A0A1H6CJ19_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72950">
        <property type="protein sequence ID" value="SEG72950"/>
        <property type="gene ID" value="SAMN04489712_11054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="136"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="200"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG72950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="46854" checksum="20D4C0B4C146F1FA" modified="2017-01-18" version="1">MKTALARVAPRNWTIRARLTALYGGVFVLAGTLLLGSTYLLVQQRLENQAGTYGAQGAAGLQRNDALAQSLLRVQNGRPLTLTGDQLAELRKLSANVLAAQEAYRRDTLESLLTQGALALGGVTVIAVALGWVLAGRGLRPVHRITETARRIADSAGRGLHERIALAGPRDEIKQLADTFDAMLERLDRSFDGQRRFIASASHEMRTPLAINRALIEVSVTRPGASPDTRTLGESLLQVNARHERLIDGLLTLADSENDLTGRHPVDLSDVVRTVLAETADTAGEAGVTVRLPRLGPAPATGDPYLLERLVHNLVENAVRHNVRHGGWLAVRTGSSGDRVWLEVTNTGPVVHRYETEAIFEPFRRLGDRRAPSRTGKDRGFGLGLSIVRAIAGAHGGHARAEPRPDGGLTVTVTLPARTPEDQAFPEPAHPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKL5</accession>
    <name>A0A1H6CKL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-Thr(GGU) m(6)t(6)A37 methyltransferase TsaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_110115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73482">
        <property type="protein sequence ID" value="SEG73482"/>
        <property type="gene ID" value="SAMN04489712_110115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023368">
        <property type="entry name" value="UPF0066_cons_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="PTHR12818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01318">
        <property type="entry name" value="TSAA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG73482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="15315" checksum="E40E15F12E171A18" modified="2017-01-18" version="1">MTETGYVVEPIGWIESPLVDDATAPLQGDEGAPEAWLVFEPQVSEGIRDLRAGTEILVLTWLDRARRDVLAVHPRGDLNRPRQGVFSTRSPHRPNPIGLHRVEIVSVEGTRMRVRNLEALNGTPVLDVKPVLDPGTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMX4</accession>
    <name>A0A1H6CMX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NitT/TauT family transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_110177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73985">
        <property type="protein sequence ID" value="SEG73985"/>
        <property type="gene ID" value="SAMN04489712_110177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG73985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="29347" checksum="81A89847F76CFC7E" modified="2017-01-18" version="1">MTATEVPQAVSAVTGVRPPRRRRSWRRVWMGVLALALTGVVWQIAAVLIGDSVTLPTVPETARTFVKYLSTPYPEVQGKTLVEDALISTGRILAGFVLGTVAGLLLGASMAGVRLVRELADPLIGVMRPLPPIAFIPLLVVWFGIGEVSKVALIFFGVLPVVTIATLGALDAVPAELLHASRSLGASPVYTMLHVRLRAAVPGVITGMRIAMGGAWTSIIAAEMIAATGGVGFLILQAGNYLQTPLIFSGIAEIAVLGFAFDGLLRLLLRLADPTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRP2</accession>
    <name>A0A1H6CRP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75661">
        <property type="protein sequence ID" value="SEG75661"/>
        <property type="gene ID" value="SAMN04489712_11169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG75661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="19038" checksum="C9A7D1CA3221110C" modified="2017-01-18" version="1">MAEELIATMNTTLGPIVLRLFPEQSPKTVQNFVGLAEGSRQWTDPRTGRPSNEPLYNGTIFHRVIDGFMIQGGDPLGTGTGGPGYKFEDEFASGLAFDRPYLLAMANAGANTNGSQFFITLSVEQTAHLTGGHTIFGEVISGTDVVDRIAKVPTGPRNRPVQDITIESVTIERRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRU8</accession>
    <name>A0A1H6CRU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_11175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75721">
        <property type="protein sequence ID" value="SEG75721"/>
        <property type="gene ID" value="SAMN04489712_11175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="386"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="457"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="524"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG75721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="619" mass="65515" checksum="25592D81CB255EF8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV76</accession>
    <name>A0A1H6CV76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_111217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76864">
        <property type="protein sequence ID" value="SEG76864"/>
        <property type="gene ID" value="SAMN04489712_111217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="202"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG76864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="36126" checksum="3AF460089B0948A4" modified="2017-01-18" version="1">MPAVTADTLTLPRLPRLPESEKAGRRVAKVVTARRSVEGEGFEVRRPFPGMDLALADPFLLLDHMGAVEYAPGEAKGTPWHPHRGFETVTYIIDGAFQHQDTTGGGGLIADGDTQWMTAGAGIQHIEQPPPELVAKGGLFHGVQLWVNLPRAQKWAPPRYQDIGSRDITLLASADGAALVRVIAGSLAGHEGPGVTHTPITYLHATVAPGARLTLPWPRDFNALAYVLSGHGTAGPEDRPVNEGQLAVFGGSHHTEHGDALTLRAADSQPLNSKNGWEVLLLGGLPLREPIARYGPFVMNTREEIVQAFEDFQAGRMGRIPAEQVPHRSAADEPIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV80</accession>
    <name>A0A1H6CV80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial proteasome activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_111196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bpa family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76707">
        <property type="protein sequence ID" value="SEG76707"/>
        <property type="gene ID" value="SAMN04489712_111196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019695">
        <property type="entry name" value="Proteasome_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10759">
        <property type="entry name" value="DUF2587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG76707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="20144" checksum="65FFFABB54A1A7C9" modified="2017-01-18" version="1">MNEPRSNEPEQNPQILVVGPNGMTVEGGDSEGDERPITEMVEQPAKVMRIGGMIRQLLEEVKAAPLDEASRARLKEIHASSIKELEDGLAPELTEELERLSLPFAEGSVPSEAELRIAQAQLVGWLEGLFHGIQTTLFAQQMAARAQLEQMRRALPAGVLPPGMTPGRGEDDQPKHPGHTSGPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZM9</accession>
    <name>A0A1H6CZM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78512">
        <property type="protein sequence ID" value="SEG78512"/>
        <property type="gene ID" value="SAMN04489712_11286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="827"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="300"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="768"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG78512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="865" mass="89667" checksum="0570302C217BE3A8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1T0</accession>
    <name>A0A1H6D1T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein, PhoT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_112183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79210">
        <property type="protein sequence ID" value="SEG79210"/>
        <property type="gene ID" value="SAMN04489712_112183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG79210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="28232" checksum="3B7D2C5C25F2DC93" modified="2017-01-18" version="1">MAKRIEISGLHAYYGAVHAIEDISMTVEPRSVTAFIGPSGCGKSTFLRTLNRMHEVIPGARVEGKVMLDDEDLYGSDVDPVAVRRVVGMVFQRPNPFPTMSIYDNVAAGLKLNGVRRKSQLDEIVERSLKGANLWNEVKDRLSRPGAGLSGGQQQRLCIARAIAVQPQVLLMDEPCSALDPISTLAIEDLIAELKSQYTIVIVTHNMQQAARVSDRTAFFNIAGTGKPGKLIEIDDTSKIFTNPSEKATEDYITGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5V0</accession>
    <name>A0A1H6D5V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80641">
        <property type="protein sequence ID" value="SEG80641"/>
        <property type="gene ID" value="SAMN04489712_113120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="160" mass="15512" checksum="DAB458600A78E8F7" modified="2017-01-18" version="1">MLAARGRSGGIADLVGDGDRVGGGVVGSGDCGGDGFGGDGFGGDGFGGDGEGFGGGGGSGGVGEGFGGHGFEGFGGFGGFGFGGWSQDASPILIRIFTRRSRRRQMPGPATAAGRDVSAAAGTTGRAAARTSRAAARTAEDRARTLSRPPRCAATPAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D735</accession>
    <name>A0A1H6D735_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80788">
        <property type="protein sequence ID" value="SEG80788"/>
        <property type="gene ID" value="SAMN04489712_113152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295581" evidence="2">
        <location>
            <begin position="30"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="32577" checksum="83BB326684BA721C" modified="2017-01-18" version="1">MRRGKRLAGAATVLLATAGCGILPGGESAGGEKTAAPPPGGWPQPVNGRVTEQMCDLLTEADYRRYGHRRFPYTSKTLGEGGSNKVACSATGGDWLTLALQPTAEAAKIEYAGTLRDHKRRMQEDQRQTILVTNVVPGADESWFDYATLGSEGSRFKEHEIQVRRGALLFSITLSGIRGEDEQDPKTVLTGLAGLVLQRLPGVGAKDTGRTLTVAYELTGQGRAKTVSYFDSATGETVSRRNVKLPWHVELPFVPTEHVGTSFQLNAQSANPTAGLGCRISVGGKLLAEQNNLGLVFCMGNYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D7Z7</accession>
    <name>A0A1H6D7Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-monoxide dehydrogenase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81420">
        <property type="protein sequence ID" value="SEG81420"/>
        <property type="gene ID" value="SAMN04489712_11452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="794" mass="84503" checksum="A0A455C0AC6044F8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9K5</accession>
    <name>A0A1H6D9K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81345">
        <property type="protein sequence ID" value="SEG81345"/>
        <property type="gene ID" value="SAMN04489712_11431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="281" mass="29500" checksum="EB9848C1D41FFD2F" modified="2017-01-18" version="1">MIVVTGATGNVGRSLVRVLAAAGEKPTATSRNITEADVPEGVEYRKADLADAESLRPVFDGADALFLQNGGPSAHTLNVGDILDAARAGGVERVVLLSSLGVATRPDSASHGVLGLSIEEAVRGSGLDWTILRPGNFDSNTYAWAPSVRAERTVTAPFGGVGLPAIDPDDIAEVAAVALREDGHAGKIYELTGPVSVTPREQAEAIGAALDEPIRFVEQTPDEARAQMLNFMPADVVETTLAILGEPNTAERRVSPDVEKVLGRAPRTYADWARANVAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DC18</accession>
    <name>A0A1H6DC18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, FadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82810">
        <property type="protein sequence ID" value="SEG82810"/>
        <property type="gene ID" value="SAMN04489712_11588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG82810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="24662" checksum="ED1A8DD39A9B8F6A" modified="2017-01-18" version="1">MTLRTARRSSLVDQVIDQLKGEIVAGAWAVGDKIPPEPVLSETLGVGRNTVREAVRALTHAGLLECRQGDGTYVRATSELSGAMRRRLRTAEILEILEVRRALEAEAARLAAARRTDADVAAIRRAQACCEEALASRDRTAFVEADLAFHTAVVEATHNRVMIDLYGDFREALRAGITASLDLLEHGDIEVPHSPIADAVVAGDAEGAERATHTCLEAVFRFLSGLPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDE1</accession>
    <name>A0A1H6DDE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL-like Lipase/Acylhydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82506">
        <property type="protein sequence ID" value="SEG82506"/>
        <property type="gene ID" value="SAMN04489712_11536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295851" evidence="1">
        <location>
            <begin position="30"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="36"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="26699" checksum="25FC9267566A9F3B" modified="2017-01-18" version="1">MRMSRAVSAALGALTALALVLFPTGISQAQENEYVALGDSYSSGSGAGDYTDTACTRSANSYPARWAAANSPRTFTFVACGGATIPDVQAGQLSALSAATTLVSISIGGNDSGFASTMLRCKLLTTSGCRRALEEARAYVDNQLPGALATLYSQIRSRAPQAKVVVVGYPYLYKVGGLCLGDLNADKRALLKDGSDALNAVIATAARNAGFAFADGRPAFAGHEICTTDEWIDPTTIHPNATGHQRGYLPAFTAAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEQ5</accession>
    <name>A0A1H6DEQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83701">
        <property type="protein sequence ID" value="SEG83701"/>
        <property type="gene ID" value="SAMN04489712_11651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="401"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="490" mass="52462" checksum="42E5FF5113455370" modified="2017-01-18" version="1">MRWDTIPEMVLSAADRFGDAEAIVDGPVRLGFAELAARVRSAAGAFAAAGVGRGDRVALCAPNSVEWIVAAFGLLTAGGVLVPVGTRLRAEEIADVVVRSRTKMMLVRQGFLGRRYGAPSGVPVIDLTEGFLDGGAPFERTVRGTDVADIVFTSGTTGRPKGVMMNHTQTLRKYSGWGDLAGLREGDRYLVVSPFSHTFGYKAGCIAALLKGATIIPVPVFDTGRVLEMVERERVTMLPGPPTVYHALLSAPGDRFTRGGHDVSSLRTAATGAADIPVELIRRIASELPFASVMTAYGLTEAGTVTCSRPGDSFEDIATTVGTPCEGMQVRIADDGEVLVRGYSVMQGYLDDPEATAQAIDADGWLHTGDLGSMDERGRLRIVGRKKDMFIVGGFNAYPAEIEGFLMEHPAVVQAAVIGVPDERLGEVGKAFVVRQGPVSVEELIAWSRTRMAGYKVPRHVEFLEELPLNATGKVMKDRLRGDWPPASTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DER2</accession>
    <name>A0A1H6DER2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83711">
        <property type="protein sequence ID" value="SEG83711"/>
        <property type="gene ID" value="SAMN04489712_11653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295816" evidence="2">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="65" mass="6392" checksum="8EAD66218662553F" modified="2017-01-18" version="1">MALMWAPSSAILAVAVAVAVAVAVAVAVALTACRAGEDGDLSRDAPHRGRLPPGGGGAGLRKERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DJW3</accession>
    <name>A0A1H6DJW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0716 protein FxsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84946">
        <property type="protein sequence ID" value="SEG84946"/>
        <property type="gene ID" value="SAMN04489712_11798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="178" mass="18795" checksum="54E2F3D009D58B50" modified="2017-01-18" version="1">MLPLLMFLAFLLLPVLEIFVAIQVSAVLGGWQTAVLLLAGSLLGAWLVRREGRRAWRALSGAFAGGATPEREPADAGLLLAGGMLLLIPGFVTDVLGLAFVLPFTRPPVRRLLAAYAARRIRAAEQRLAAQGLDGMFGPGADLPPHLGFPPRPGPATGRRPADGPVIQGEVIHDDRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKU4</accession>
    <name>A0A1H6DKU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ORF">SAMN04489712_11874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85759">
        <property type="protein sequence ID" value="SEG85759"/>
        <property type="gene ID" value="SAMN04489712_11874"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG85759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="16261" checksum="E66E20F2DD37A255" modified="2017-01-18" version="1">MGAQIPRVGVGTDVHPFGSGRPLWVAGLHWPGEGDGLSGHSDGDVAAHAACDALLSAAGLGDLGAVFGTADPRWHGASGTDLLREVARLLAERGCVIGNVAIQVIGNRPKIGRRRAEAEKTLSEALGGACVSVSATTTDGLGLTGRSEGLAAIATALVVPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DL94</accession>
    <name>A0A1H6DL94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86207">
        <property type="protein sequence ID" value="SEG86207"/>
        <property type="gene ID" value="SAMN04489712_11919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="26848" checksum="E8E9D2012BEB1E05" modified="2017-01-18" version="1">MDIRGKAALVTGAASGLGRATAQRLVADGAHVVLLDLEGSDGELVAKDLGGTAEGRVRFVAADVTDSEQVDAAVKAATELGELRALVHCAGRGGPVRVVEKDGAPGSMEQFQGVIQTNLIGTFNVLRHAAAAMVPLDDLPDGERGVCVLTASVAAWEGQIGQLPYAASKAGVVGMTIVAARDLARNHVRVNTIAPGLFDTPILSRVPEQVRDRLAASIPHPARLGDPADFALLAAHIITNPMLNGETIRLDGAIRMAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNE5</accession>
    <name>A0A1H6DNE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86263">
        <property type="protein sequence ID" value="SEG86263"/>
        <property type="gene ID" value="SAMN04489712_11936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="19819" checksum="7DCDED6E25B45DAC" modified="2017-01-18" version="1">MSNGRRRGRPRDPAVDRVILRETLALLDSGGYERLRMADVGRKAGVGLGSLYRRWPTKYALVVDALRAAAPAREVELTDDPVEDLAAVLEAFAEELGDRGTLLAVLLTDPASEVAAAVREAKIHPASEATRERLHRVIGPVPDLQIRADVGPALIFQHLLLHGAPPEETQIREHILPLMTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNK2</accession>
    <name>A0A1H6DNK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_11958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86343">
        <property type="protein sequence ID" value="SEG86343"/>
        <property type="gene ID" value="SAMN04489712_11958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="31"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG86343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="30256" checksum="BA61EDF050E53493" modified="2017-01-18" version="1">MAEMLKRGSPAGAGRGPGIPEDVPVLAVDGLVVEHRNRTTGEVFRAVDGVCLRIGAGESAAVVGESGSGKTTLAMAATGLGPRSGGEIELLGHSLDAIGRRRLRELRREVQIVFQDPHGSLDSRQSVRSGLRELRGLQRERTAWIDDAGLLERVRLSPDLLDRYPHQLSGGQAQRVCIARALLMRPRLIVADEPTSGLDVSVQADVLELLREVRESTGAAMLMISHDLAVVRAVCDTAHVMRHGRVVESGPCETVFTSPADDYTRELLAAMPGGRWRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPQ6</accession>
    <name>A0A1H6DPQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_119107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86545">
        <property type="protein sequence ID" value="SEG86545"/>
        <property type="gene ID" value="SAMN04489712_119107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="47"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="775" mass="85159" checksum="C543FA6526646E7C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQ38</accession>
    <name>A0A1H6DQ38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase YjhB, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_120111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87321">
        <property type="protein sequence ID" value="SEG87321"/>
        <property type="gene ID" value="SAMN04489712_120111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="130" mass="14173" checksum="5196E99C40124921" modified="2017-01-18" version="1">MLDVVAWIHTADRRMLAVRARGRDLLYLPGGKREAGEEDWAALSREVREELAVELDHGTFRELGVVHAPAHDQPEHTHVRMACFTAGFHGRIGPAGEIDECVYVGAGERDLLAPAARAAFDLAAAHDLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRK5</accession>
    <name>A0A1H6DRK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal recognition particle receptor subunit beta, a GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88007">
        <property type="protein sequence ID" value="SEG88007"/>
        <property type="gene ID" value="SAMN04489712_12157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG88007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="217" mass="23168" checksum="EF4CC6752DAFCDA1" modified="2017-01-18" version="1">MVSNSSDTHPPAPAPARPAYIDDTVEQSVKLLVAGSLGVGKTTFISRLSEIPPLCTEALMTTLGKGTDRLDGLDHKSTTTVAMDFGRITLTPRKAPPLALYLFGTPGQQRFWNVWEGYGLAAGAAGALVLVDTRRLDDSFEVLDQLETRAPHLPTVVAVNLFPDSADHDLGTVHSKLDLPAHTPVTTCVAIDRDSAKQALIALVRHALDLTAEGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRL5</accession>
    <name>A0A1H6DRL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-(Acyl carrier protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_120119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87366">
        <property type="protein sequence ID" value="SEG87366"/>
        <property type="gene ID" value="SAMN04489712_120119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="25922" checksum="6EC738B2E2BBD917" modified="2017-01-18" version="1">MDTAVDFSGRAVLVTGGTRGIGAVIAEAFLAAGAEVTVCGRGEPGTLPGAGGRTARFLAADIRDAGAAAELVERAAARMGRLDVLVNNAGGSPDADAATVSPRFVERIVQLNLLAPFYVAQPANKIMQGQETGGSIINIGSVSGSDPQPRTAAYTAAKAGLLALTRALALEWSPKVRVNHITTGLVLTEAAAHNYGDDDGATIGALIPMGRMAVPQDVANACLYLASDLASYVTGADLAVHGGGEIPARYVVTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DS03</accession>
    <name>A0A1H6DS03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88018">
        <property type="protein sequence ID" value="SEG88018"/>
        <property type="gene ID" value="SAMN04489712_12158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="430" mass="47429" checksum="6F0BB4650BFC716C" modified="2017-01-18" version="1">MTRSAGRLADMTGLTPLADITASRDLPAAYARLRRQYGQVAPVLLEKGRQREINGWLLLGHREILDVVQDERRFARDPNHWRDYAQGLVDPDSGLGPMMFPRDNAYFADGDTHRRLRAPLDEGLRELDQHAMQRRIRAICTELTRGFVGRGHADLIAEYASYIPMLTVAGTMFGIDLDHGRRLRDGLLALFGSGTDSQDGYRDVQQILGEVLHARKAAPAGDLTTAFLHHPNLRNDTEVMQEMLLMISAGYETTAIWIARTLLLMLGDPRFSGNIRGGTLGVNEALDEVLRLDPPMTHMPARFPLADCQIDGRRIERGDALILGLAAAGFDPRIHTGDWWQEIDNRSHLGFSAGSHTCPAKIPARLITRVAVETALHELPGVTLADPQAPVPLIPSPWTRHPAHLHVVFPAADRLRTAAVPPGPPATAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DS17</accession>
    <name>A0A1H6DS17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator YhcF, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87864">
        <property type="protein sequence ID" value="SEG87864"/>
        <property type="gene ID" value="SAMN04489712_12121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="13145" checksum="FE6F1959AFECB8B8" modified="2017-01-18" version="1">MIVIDADSPVPPFEQLRAQLARQIQDRTLAVGSRLPTIRRLAADLGLAVNTVGRAYRELEEAGLIETRGRAGSFVSAAGEQARERARQAAADYAAVVASVGIDNSEALRIVEAALGCCDAAAPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT66</accession>
    <name>A0A1H6DT66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88491">
        <property type="protein sequence ID" value="SEG88491"/>
        <property type="gene ID" value="SAMN04489712_12213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="65" mass="6963" checksum="97ADEAF5F23F1138" modified="2017-01-18" version="1">MLLPLVRRAVRPDVDVELAPWTLACPVGNCLQAGLLTSDGKRNDTRRMTPPRCITCALACAGSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVI5</accession>
    <name>A0A1H6DVI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase, TrmH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89382">
        <property type="protein sequence ID" value="SEG89382"/>
        <property type="gene ID" value="SAMN04489712_12380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="30665" checksum="BCD5B8B09F82648B" modified="2017-01-18" version="1">MAGRELTSIRSPRVKSARRLAKRTFRHRDRSFLAEGPQAVREALELPGVLSELFTTAEAESRHADLVTAAERAGAPVLRVSGEVMAELAQTVTPQGLLAVCRFVDVGLAEALAPRPRLVTVLAHVRDPGNAGTVLRTADAAGSEAVVFTDASVDPYNGKCVRASAGSLFHVPVVAGPRFGTLIPALRDSGLTVLAADGAGDRTLDSAIDDGLLARPTAWVFGNEAWGLPEEILRDVDEVVRVPIYGRAESLNLATAAAVCLYASARAQRTGCSDRPAPGGPVAGEASTGTERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DY37</accession>
    <name>A0A1H6DY37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Permease of the drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90151">
        <property type="protein sequence ID" value="SEG90151"/>
        <property type="gene ID" value="SAMN04489712_12553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="16"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="149"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG90151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="360" mass="38225" checksum="BCDB8CAD0814D327" modified="2017-01-18" version="1">MSARRDFRLALAVGALVAITAVWGSTFPISKDLLTRQPVPDFLALRFLTAALVVGLVRPGALLRAGWRVVGVGVGLGLIYFTGQYLQFVGLQHTAPTVSAFVVSMYVVFTPLLACLLTRKLPSPRTAIATVLATAGVAVMSLRGFSLGWGEMLTVFAASLYAAHILALGRWSRARTAYALAVVQLGTMGLAFLAVASIDGVQLPEARDIPAFLYLAILAGGIALLGQTWAQAHLPAPTVSIIMVLEPVWAGVIGVSVFGERLDARIILGGILILFALVVITDRSRGTYADGVRRPRWRRRPTGVAAGASVVIADVGTQAVAPDQEDGQDVARRARHDKARDEHDEVADQPEGFAGDRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZA5</accession>
    <name>A0A1H6DZA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90690">
        <property type="protein sequence ID" value="SEG90690"/>
        <property type="gene ID" value="SAMN04489712_12710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="663"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="696" mass="76634" checksum="3796A34A05A922C7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZM2</accession>
    <name>A0A1H6DZM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90105">
        <property type="protein sequence ID" value="SEG90105"/>
        <property type="gene ID" value="SAMN04489712_12540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="102"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="15632" checksum="C4A974EA29B22F77" modified="2017-01-18" version="1">MNVATSSSCVFCRIVEGSEAAEIIYESDRSVAFLDIAQATRGHTLVVPRTHRRDLSDIEVDEAAAVMSAVVWVSNRLTRRLQAPGINLWHASGETAWQSVFHFHIHVVPRYTTADLAKPWTEAESPLESLRGLADHIRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0N4</accession>
    <name>A0A1H6E0N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase YagR molybdenum-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91132">
        <property type="protein sequence ID" value="SEG91132"/>
        <property type="gene ID" value="SAMN04489712_12844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="697" mass="75164" checksum="D95EC31FAA58D4CA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1M4</accession>
    <name>A0A1H6E1M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative drug exporter of the RND superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91437">
        <property type="protein sequence ID" value="SEG91437"/>
        <property type="gene ID" value="SAMN04489712_12917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="516"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG91437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="710" mass="73906" checksum="62471D41AC173971" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1Q0</accession>
    <name>A0A1H6E1Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91467">
        <property type="protein sequence ID" value="SEG91467"/>
        <property type="gene ID" value="SAMN04489712_12926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="23"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="270"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG91467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="41374" checksum="E2A17D0B66550404" modified="2017-01-18" version="1">MRSVLVGGVGMIPFTKPGAGDPYDVMGERAARAALDDAGIGYDQVQQAYVGYVYGDSTSGQAALYGLGQTGIPVVNVNNNCSTGSSALWLARQAVASGAAECVLALGFEQMTPGALRALWEDRPTPFARSMSVMHGLQGESQAPLAPQMFGGAGAEYAARYGTKPETFAKISVKARRHAARNPYAVFRTEVTEEEVLASPHIYGPLTRLQCCPPTCGAAAAVLCSPEFAARYRISEPVAIRAQAMTTDTPTTFDDSATMMTVVGYDMTRAAAHQVYEAAGVDPGDIGVVELHDCFTANELITYEALGLTPEGTAEKFVVDGDNTYGGRVVTNPSGGLLSKGHPLGATGLAQCAELVWQLRGRAEARQVDGVRLALQHNLGLGGACVVTLYEPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4H2</accession>
    <name>A0A1H6E4H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92201">
        <property type="protein sequence ID" value="SEG92201"/>
        <property type="gene ID" value="SAMN04489712_13255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="107" mass="11453" checksum="19C8BA35CC9515C2" modified="2017-01-18" version="1">MPDRRSGRHTGRAWDAPRETDTRRAQVWALAQVLKAHGYGVEVAESEPLLVVAVSSGSPVQVRCDYRQDCGGEPWFFLTGGGPLAAADGDHLQDAVVAVKGALARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4P2</accession>
    <name>A0A1H6E4P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE superfamily endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91984">
        <property type="protein sequence ID" value="SEG91984"/>
        <property type="gene ID" value="SAMN04489712_13157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="1">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="29300" checksum="747CE5581FBA97E8" modified="2017-01-18" version="1">MQRQYSSTAGRTENCQIGVFLAYASPCGHALIDRELYLPESWTADRDRCRAAGVPDQVEFTTKPRQAMVMLGRAPAAGMPFAWVTADEVYGQVKYLRVWLEEHDAAHVLATKRNDTLITATGGQARADELVAELPARSWRRLSAGAGANGPREYQWARVPIRIGWRPGRGHWLPARRSLADPGDLCYGSHRATLADLAWIAGARWRIEECFQQAKNDAGLDHYQVRTWRAWYAHITLAMLAHAWLAVARSLVAKGEPAPASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E738</accession>
    <name>A0A1H6E738_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_13919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93512">
        <property type="protein sequence ID" value="SEG93512"/>
        <property type="gene ID" value="SAMN04489712_13919"/>
    </dbReference>
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    </dbReference>
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            <begin position="318"/>
            <end position="341"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG93512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="341" mass="35391" checksum="289115F0E4FDA058" modified="2017-01-18" version="1">MNKNVTRALWAGLLCLLALAPFVVGTVEISAFQKVVYLSVAVMSLNVLTGFNGQASIGHSAFMGIAAYFTALAVQSHGWSYWAALPASILVAALVGALAGVPALRIRGMNLALVTLGLGMVFPQLPIRFTEETGGTQGMPVDEPLAAPAFLNVSDVAWRYWVLLALAALVFWLVRNFRASRVGRAVIAIRDQPIAAHTAGVNVAATKIAVFAVSAGMAGLAGWMFTVANQFVSPSDFTVLVSINLLLGMAIGGSGTLAGPVIGAVFLHYIPEAVNGTGIDPVLTPALYGLILILVVYFLPGGAAGGLAQLSARFAASRRSPDEPGQAPPSTPRLTSSTSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7A8</accession>
    <name>A0A1H6E7A8_9ACTN</name>
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        <submittedName>
            <fullName evidence="8">Phenylpropionate dioxygenase, large terminal subunit</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">SAMN04489712_13541</name>
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                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">DSM 43163</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0520">NAD</keyword>
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        </source>
    </evidence>
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        </source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51296"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG92824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="400" mass="44233" checksum="3A59F49564D83F4C" modified="2017-01-18" version="1">MTDIAVPPGRSAAPLDESLTDRALDIAVRKTTEMADSTLAVPLSYYRDPALYERELALLKTTPLAIGQSAQLTEPHAYFVRTVLGSSLLVTRDADGKAHVFLNYCRHRGARPAEGEGVARRFTCPYHAWSYDSKGCLASFPGRAGFPNLDKSRYGLVELPSQERHGFVWAVLTAGAPLDLDAHLGPLDAELAQWRYQDYGYLTAREFTSGVSWKGALEAFAEGYHFPFVHGESVIGQNTLADTSIHDTFGRHHRMGFPFNWITALADAPGEATRPDRTPSANMGIIYWIYPNLILANSMVGVEIIDMLPHDAPTTCTVRHSWMGVTPATDEVTTAMYQDVYEQVHAAVRDEDFLMLPSCGDGVRNGQHDHMLIGRNEIGVQHMIRTMADVLDIALDTDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7K1</accession>
    <name>A0A1H6E7K1_9ACTN</name>
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        <submittedName>
            <fullName evidence="11">Amino acid/amide ABC transporter membrane protein 2, HAAT family /amino acid/amide ABC transporter ATP-binding protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_14014</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
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            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="SAMN04489712_14014"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LivM-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="231"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
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        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
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        <location>
            <begin position="344"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG93690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="596" mass="61913" checksum="C0CE4EAB18B90BEE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7Q8</accession>
    <name>A0A1H6E7Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93179">
        <property type="protein sequence ID" value="SEG93179"/>
        <property type="gene ID" value="SAMN04489712_13736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="252" mass="27249" checksum="33BA6CEAB06098CA" modified="2017-01-18" version="1">MRARGLREQVKPGRHEAGPGRMPGHAVVLAVIAGLSYSTFVLGHFLNPDLDLINAYVSELSAVNQPFRAVFNTGDLVTGVCSVLVAVTALARLARRSLARAGWTFLLLFGACAIGDAVFPLDCAPSLQTWCALREQAQQVSFSHQFHAVTSSFVIVFGVLALFTLSLAARRYGWWPTLARWGRILAVAEALCGLGTLLLMIRGSWLGLMQQVQIGILCAGLLVIARALHEDRVARPSVLAAGPARRCHEPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SE15</accession>
    <name>A0A1H5SE15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47997">
        <property type="protein sequence ID" value="SEF47997"/>
        <property type="gene ID" value="SAMN04489712_101147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF47997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="109" mass="12151" checksum="3C37C23A4F1CCA0E" modified="2017-01-18" version="1">MTPPPPGTLQPPIDPVTARQLPPGEVPNPEYERLYHAYRDAYGSIDRLREALDPPARTLAGTDAWLGPEARSWGGRLEDNRRILQQAADRILSDMHATLVATSRTIQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SQW5</accession>
    <name>A0A1H5SQW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisI</name>
        <name evidence="9" type="ORF">SAMN04489712_101326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52949">
        <property type="protein sequence ID" value="SEF52949"/>
        <property type="gene ID" value="SAMN04489712_101326"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF52949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="125" mass="13977" checksum="C910BF1AA4567503" modified="2017-01-18" version="1">MSQRPSDLDPKIAARLKRDPNGLVPAIAQQYDTGEVLMMGWMDDEALHRTLTTGRCTYWSRSRQEYWVKGETSGHQQWVKSVALDCDGDAILVKVDQVGAACHTGDRTCWDADVLDAVIGERPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T323</accession>
    <name>A0A1H5T323_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57282">
        <property type="protein sequence ID" value="SEF57282"/>
        <property type="gene ID" value="SAMN04489712_101466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="222"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF57282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="375" mass="38949" checksum="E72C42E98C03F9D5" modified="2017-01-18" version="1">MSAEDLRLLRETVREALADLSPAAEVRRQMETAQGWDRKTWRRLCDELGLAGLAVPEEYGGGGFSPVELGVVFEEAGRSLLCAPLLATAGLAIPLLLALDDEEARREYLPGLCDGSCVGTVVTTDATGRPLPGGACVEAVERDGGTRLHGTGGFVLDGASADLVLVPARTDAGPAVFAVEAGAPGLAVTPLVTLDPTRKQATLVFDGAPARRLGTGDAAAAIGRAFDVARAMLAGEQAGGAGRCLELVVEHARSRVQFGRPIGSFQAVKQKAAQLLIQVESARSAAMAAAQAAAGDGTGELGELPAPAVVSAVAKAYCSDAYVAVAAETIQLHGGIGFTWEHDAHLYFKRAWTSAELLGRPDEHIESLARHLENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TAW4</accession>
    <name>A0A1H5TAW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein, family 5 Middle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF59965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF59965">
        <property type="protein sequence ID" value="SEF59965"/>
        <property type="gene ID" value="SAMN04489712_101550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="94"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF59965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="518" mass="55899" checksum="9E43AF41C7425F75" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V537</accession>
    <name>A0A1H5V537_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monosaccharide ABC transporter substrate-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82314">
        <property type="protein sequence ID" value="SEF82314"/>
        <property type="gene ID" value="SAMN04489712_102165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009286903" evidence="2">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="55"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF82314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="36717" checksum="BBA55E7E2094B1C4" modified="2017-01-18" version="1">MTDTSRRGFLFAGSIAGAGMLAAACTSNSEETGNTNQQSVSTGGDNDKPGTKVTIGFSAPAADHGWIAAIAKNAEAQAKQYSDVDFKPVEPTNDINQQISAVESLIAQKVGALVILPNDGEQLNQVARKAMDAGIPVVNLDRVFPDKLSYRTWVGGDNYGMGVAAGHYIGKKLKDKGVAKPVILEIQGIATLPLTQDRSKGFADALKTYGFSVTAKQDAKFTVESGNQVAGNLLQAHKKIDALWNHDDDQGVGVLAAIKQANRNEFFMVGGAGSANAMREIKNGGVLEATVTYSPSMASSAIKLARLIAQGKGMADLVEKQVPQSITLASETITKDNVDRYLPLGFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VDE3</accession>
    <name>A0A1H5VDE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84487">
        <property type="protein sequence ID" value="SEF84487"/>
        <property type="gene ID" value="SAMN04489712_102245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF84487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="12518" checksum="D6823F55C7497992" modified="2017-01-18" version="1">MCSPVISMMRKSQQPWTAPCFGPSAFVPESSVLTLPSPYSFTGDGGNGGDHPFAMVRQMYGGVARLRDGRQLQQVQDERQGWSVFCEGTTELIALTAHEGAANGGVSGPYPWRQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VLZ5</accession>
    <name>A0A1H5VLZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88046">
        <property type="protein sequence ID" value="SEF88046"/>
        <property type="gene ID" value="SAMN04489712_102365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF88046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="13600" checksum="F5C05260FFE8BBD4" modified="2017-01-18" version="1">MRIPKRVNAAWDWAESHGRVMALVFLLPILAVGALWSPVLAAFALGAAGGGMVTYTRLSKRITRLRGEVDDLLRECGRLRHRNNMLASGIVQNDVMVTQKLLSIPELREYEAEDLGDERRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VM32</accession>
    <name>A0A1H5VM32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine-gamma-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88304">
        <property type="protein sequence ID" value="SEF88304"/>
        <property type="gene ID" value="SAMN04489712_102374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF88304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="406" mass="43198" checksum="4C5BE0E146B6C09E" modified="2017-01-18" version="1">MDDNLHPQTRAVHPPVIRPVDSTPLTTPIYQGHLFSFEDAKTMAAAFEGPARTVDGGDGHSAFFYSRQGNPTVRSFEKAVSDLEGGADALATGSGMGAVNTVLMTLLRSGDHVIAQRSLYGGTYVLLHDLAERWGVELTHVSGDDPDEVRAALRPNTRLLYLETITNPTTQVVDLPALASVAREAGVLTVVDNTFATPMLCRPLEHGVDIVLHSATKYIGGHSDLLAGVVVCADPAVHHRIWSHATELGGSTDPTTASLAVRGLATLPLRVARQCENALFLARRLAEHPAVERVYYPGLPSHPQHAIARRLLDGGFGGVLSIDLVGGREAGRRFTESLRLVAMAASLGGTKTLVLHPASTSHRGLDAQALAAAGIGEGTVRLAVGIEHPDDLWNDLEQALAADHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VZA6</accession>
    <name>A0A1H5VZA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92358">
        <property type="protein sequence ID" value="SEF92358"/>
        <property type="gene ID" value="SAMN04489712_102521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF92358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="65" mass="7750" checksum="9F5D7FEBB8D9C8A4" modified="2017-01-18" version="1">MTADDDEYMTVTEFLAKIGGVSRRTFYRWRELGIAPVCHQLPNRELLIRRDDFRTWMESLREDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W257</accession>
    <name>A0A1H5W257_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted kinase, aminoglycoside phosphotransferase (APT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93582">
        <property type="protein sequence ID" value="SEF93582"/>
        <property type="gene ID" value="SAMN04489712_102562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="56"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF93582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="350" mass="40119" checksum="41E26AD64253B1D0" modified="2017-01-18" version="1">MPVPDQRDPDTTRRLLAGWLARRLPGARVLHLETPRTTGFSSETLMFEMECDGRRESLVARVAPLAYQIFPEPRFAEQYRLMRILDERTDIPVPAIRWYEPSTEPLGAPFFVMARVDGDVPTDMPPYHMDGWVTQAPPRERSAMWWSALEILARLHRLDVAELGLEFLDQPHWGPTGVRQRLGYYEHYLGWAYQGPQEVALRALRWLKANIPEEPDPPVVLWGDARIGNVIYRAGVPQAVLDWETAMLGAPEEDLAWYLFLDRHHCEGVGVPRLEGFPSPEETVARYAELLGRPLRDMTYYEVLSGFKFAVIMARIGQAMLDFGWITPDDPFPHDNTSTRLLDTVLKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W7H4</accession>
    <name>A0A1H5W7H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95350">
        <property type="protein sequence ID" value="SEF95350"/>
        <property type="gene ID" value="SAMN04489712_102617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF95350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="17468" checksum="1BBBE00430EAEBD6" modified="2017-01-18" version="1">MRVYLPSTLAGLARVLSTGEIGPAPVSGYAVTPALREWYAEGDTEELEYAAMTAAARASLRLLAEEMAADPQTPPRRVVLAVEVPEGTVQPGGRDDERALVQVTAPVLVRDIAAGHVDDSAAADDVRAAVRALPAADAGDEDALFTVEGAEGHELMWYATQELGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WYZ7</accession>
    <name>A0A1H5WYZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04708">
        <property type="protein sequence ID" value="SEG04708"/>
        <property type="gene ID" value="SAMN04489712_10321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG04708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="866" mass="93091" checksum="4F5F6ECB96CAA089" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X9C6</accession>
    <name>A0A1H5X9C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08045">
        <property type="protein sequence ID" value="SEG08045"/>
        <property type="gene ID" value="SAMN04489712_103139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG08045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="30829" checksum="252708BDE2A0B5D3" modified="2017-01-18" version="1">MRRIAWRLVKGTAVAAFRYRVTGLAAEAAFFALLSLPPLVIGLIGTMGHLRGALAGETVADIRAWLIRQAHKVLTGPAVDNVVTPLIDDVVRGGRVDIVSISFLLSLWAGSRATNVYVDTITIAYGLSGVRGVVRTRLRAFGLYLIGLVVMIIVIPLLVAGPALVRQALPEGAAFVRLLYWPVVVTLSIMFLATLYHMSVPVRTAWWRAVPGAAVALTIWILGSVGLRVYLAGSLSGVSVYGSLGAPIAILAWLYVAALAVLIGAALNAEVDRMWPGEDTARARAARGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XU62</accession>
    <name>A0A1H5XU62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15193">
        <property type="protein sequence ID" value="SEG15193"/>
        <property type="gene ID" value="SAMN04489712_103408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG15193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="299" mass="33626" checksum="CADE46B7A01B629A" modified="2017-01-18" version="1">MSGRVEPAKALASQFRGGPTALRIMVGAQLRRLRESRGLSAEDAGYAIRASQSKISRMESGRVGFKARDVADLLTLYGVRDEDERDAILSLARQSNMPGWWHQYGDIIPGWFEAYLGLEGSASFIRIYETQLIPDLLQTEAYARTVIGLQRPMASQAEVESRVGMRMGRQRMFDQSDPPRLWAVFDEAALHRFLGHRALIREQLRHLLDVLDRPNVTLQIVPIGSPLGVLSRNPFSILRFPPPELPDIVYIEQLTNALYIDKGEDVAAYRQLLDKISMSALSVKDSTILLHRLLTELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZQ8</accession>
    <name>A0A1H5XZQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17234">
        <property type="protein sequence ID" value="SEG17234"/>
        <property type="gene ID" value="SAMN04489712_103489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG17234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="46941" checksum="CDCED286E13E06E0" modified="2017-01-18" version="1">MTLAKVFEELVGAGAPVELTAYDGSRAGLLDADLRVHVKSPYAMSYLVHSPGALGLARAYVSGHLDVHGDIYTLLHEMTQLMDSMTVQARLRLLAGVIDDPLLRAAVSRRLEPPPQEVRTGRTSWLRHTKRRDARAISHHYDVSNTFYEWVLGPSMAYTCACYPSEDATLEEAQFHKFDLVAKKLGLRPGMRLLDVGCGWGGMVMHAAKHYGVQALGVTLSKQQAEWAQKAIAEAGLTELAEVRHLDYRDVQEGDFDAVSSIGLTEHIGKANLPSYFGFLYGKLKPGGRLLNHCITRPDNTQPSMKKGGFINRYVFPDGELEGPGYLQSQMNDTGFEIRHQENLREHYARTLAEWCRNLDDHWQEAVAEVGEGTARVWRLYMAGCRLGFERNWIQLHQVLGVKLDGDGDARMPLRPDWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y032</accession>
    <name>A0A1H5Y032_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, Tic20 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17283">
        <property type="protein sequence ID" value="SEG17283"/>
        <property type="gene ID" value="SAMN04489712_103491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG17283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="187" mass="20067" checksum="8A15279C31D663AD" modified="2017-01-18" version="1">MTGGRPGTDHEGMDNGGYTVTGLRISDAEREPAIESLKEAYAEGRLDHEEFDMRMHLAMTAKTHSELAAVVADLGRPVPQYASKEVVAGAADGEDRMLAALAHGSGMVPVIIPPLAIMLLSGRRSQYVRRHAAEALNFQLTLLLVTIVTFGLGGVVYAVAWIAALVGAVVALTGQDFRYPWILRAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YM54</accession>
    <name>A0A1H5YM54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25158">
        <property type="protein sequence ID" value="SEG25158"/>
        <property type="gene ID" value="SAMN04489712_10486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG25158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="18762" checksum="BBF13B3CCD993857" modified="2017-01-18" version="1">MTRNPTTEPFSVRLEVRSYEIDPQLHLNGGFYVQYADHSRFACVQAAGISIEDLLGSGIGPVNLETVIRYRSELRGGDQVDVSCDWEWGTGKTYRVHHVLRHLDGTVAAEVDHVSGLLDLKTRRLITDPDHEWRTRADRPELLGLGPHDPHNEGSVRSTAPLCDKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YMW3</accession>
    <name>A0A1H5YMW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25324">
        <property type="protein sequence ID" value="SEG25324"/>
        <property type="gene ID" value="SAMN04489712_10490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG25324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="57" mass="6109" checksum="CCE9020FDEB4C050" modified="2017-01-18" version="1">MPPGRVRPGIGQGRDGAASTWTKFPACRAEFRDESGSDVAVFTRADDRNPLVASLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YR00</accession>
    <name>A0A1H5YR00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-6 DNA Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_104116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26025">
        <property type="protein sequence ID" value="SEG26025"/>
        <property type="gene ID" value="SAMN04489712_104116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="173"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG26025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="712" mass="75540" checksum="DB18DCF82FBB1713" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YUG4</accession>
    <name>A0A1H5YUG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_104188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27638">
        <property type="protein sequence ID" value="SEG27638"/>
        <property type="gene ID" value="SAMN04489712_104188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="301"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG27638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="436" mass="46883" checksum="AA96C3A2B78BA1F6" modified="2017-01-18" version="1">MGRSVCALRRGPASGDAVVESRDGRRVVRSAGAMLVVAALGVSSGAFGLAGRATGEPVPSAGEVARGKQQVRDRAVEVGRLKAQLATADGELEELAIRAETAVERYNGELVMLDRARQEQQAAEDRLAEAERRYETIRTELAGFAATAYRTEGGTGSWAGMITGRGGPQNAMDRAGLVEMMERHRTGALQKTRAARDVADVFRGRATAAFRGQQDALQRAEAAKRAAEEAVDRQHASMTRLNEDKERAERLLSAAEAQARRLEGKRREALETRLRGSSVTKLSRRRSLGAGRGTSALLQGSSRAAVVVQSALRWLGTPYSWGGGNANGPSYGIGRGRGTKGFDCSGLALHAWAKVGVRLDHWTGTQWTSGPHIPLNMLRPGDLVFFARDTRNPDTIHHVGIYVGRGQMVEAPYTGARVRISSIWRRGLIGATRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZP4</accession>
    <name>A0A1H5YZP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29789">
        <property type="protein sequence ID" value="SEG29789"/>
        <property type="gene ID" value="SAMN04489712_104282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025323">
        <property type="entry name" value="DUF4229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14012">
        <property type="entry name" value="DUF4229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG29789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="85" mass="9234" checksum="CAA65F42BF42C1D3" modified="2017-01-18" version="1">MRSVLAYTAARLAIFAATFAVLYLLPVLDHSKPESMLLILALSVIISGVVSYVLLTGLRDAVSSAVVTGIGKRRHKFEESRSKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z0Y3</accession>
    <name>A0A1H5Z0Y3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29700">
        <property type="protein sequence ID" value="SEG29700"/>
        <property type="gene ID" value="SAMN04489712_104278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG29700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="319" mass="35167" checksum="8DC444CECAB19621" modified="2017-01-18" version="1">MRYRGIRRRSRERPDEGFAPSPPEQSPSPERGQRWAPTRPRSSQPRDRWGRFRKGGRDDDFALRTPADTGGGPEGAADRRSAGARGRPSEAQRTGPSWRDFELDTDLPRAAPHAPGTPSFGDGRRHCGPLEDILYRQWDADQGPPTPEVVRAVESLAALPEPLKERLAAGLDGIYVGRGGVPQLDDMGHLAGRPLPSGRATWDICAGAYGDRKIVVGDRPSPTPDVMMHEVGHALDDLDGQGGHWQSDSAAFRALYDRCLPHLASDFHRQPAELGRREFFADAFAAISARQRPALVDMLGGDIRLALDVMLFFNRRYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z346</accession>
    <name>A0A1H5Z346_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30741">
        <property type="protein sequence ID" value="SEG30741"/>
        <property type="gene ID" value="SAMN04489712_104322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="69"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG30741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="355" mass="38398" checksum="6AFFEB128CF5E521" modified="2017-01-18" version="1">MSELHNGNGHGALSLVPKTDVRQTAKDFKTDQEVRWCPGCGDYAILAAVQSFLPELGLRRENICFVSGIGCSSRFPYYMNTYGFHSIHGRAPAIATGLAASRPDLSVWVVTGDGDALSIGGNHLIHALRRNINLKILLFNNRIYGLTKGQYSPTSEVGKITKSTPMGSLDAPFNPISLAIGAEGTFVARTIDSDRKHLQSVLRAAAQHNGTALVEIYQNCNIFNDGAFDPLKDPEVRDDVTIRLEHGQPIVFGADGGKALRRSGFGAFEVVNVADVDPSEIVVHDAHHPDPSLAFALSRLDSPAFEHTPIGIFRQVERPSYDEQMRAQLDEAVTGQGPGDLAALLASGDTWRIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZD6</accession>
    <name>A0A1H5ZZD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ascorbate metabolism protein UlaG, beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40826">
        <property type="protein sequence ID" value="SEG40826"/>
        <property type="gene ID" value="SAMN04489712_10552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="58"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG40826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="30793" checksum="F1024F7E941320CF" modified="2017-01-18" version="1">MADVPVPGGSGPAITRDAVTFVGNATVIIHYGAFTLLTDPNFVPRGHRVHLGYGIVTTRLKDPALAVEDLPELDAVVLSHLHGDHWDGVAERHLDRSLPIVTTQAAARALRRRGFGEADGLEIWRHRTLTKGDRWVRITALPGRHGPDPVHLLLPPVIGTLLEFGTGGSTDLRLYQSGDTVMYDQIAEVRHRYPDIDLGIVHLGGTRPLNLVTVTMDGRQGADWVETVQPDRVMPVHYDDYSVMKSPLSDFEAELRRRGLSDRMIPVERGGSIPLTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A032</accession>
    <name>A0A1H6A032_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribose pyrophosphatase YjhB, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41770">
        <property type="protein sequence ID" value="SEG41770"/>
        <property type="gene ID" value="SAMN04489712_10598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG41770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="132" mass="13958" checksum="DF629F89B6FD45D0" modified="2017-01-18" version="1">MRTVRCVGAIVRDEAGRLLMIRRGHPPGEGLWSIPGGRVEPGESDAAAVVRELHEETGLAVRVGGPAGVVRRPGPENVTYEIHDYVAEATGGTLRAGDDAADARWVTAEELRGLPTTAGLLEALTAWDLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2C6</accession>
    <name>A0A1H6A2C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, Lrp family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_105165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42878">
        <property type="protein sequence ID" value="SEG42878"/>
        <property type="gene ID" value="SAMN04489712_105165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG42878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="16806" checksum="C0C19F1CC8084659" modified="2017-01-18" version="1">MRLDDLDRRIVARLLEDARASYAQIGDAVGLSAPAVKRRVDRLREEGVITGFAAVVDPAALGWTTEAFIEIFYNGARSPEETYESVRRHPEVIAAYTVTGEADALIHLRARDIAHLEETLERLRREPKIAQTKTSIVLSRLIGRPTDGPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A548</accession>
    <name>A0A1H6A548_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bipA</name>
        <name evidence="4" type="ORF">SAMN04489712_105220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43859">
        <property type="protein sequence ID" value="SEG43859"/>
        <property type="gene ID" value="SAMN04489712_105220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG43859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="617" mass="67959" checksum="2CFC6EC76C00A197" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A5R2</accession>
    <name>A0A1H6A5R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43385">
        <property type="protein sequence ID" value="SEG43385"/>
        <property type="gene ID" value="SAMN04489712_105193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG43385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14021" checksum="F61E74750B30BDBB" modified="2017-01-18" version="1">MNRPVRAFLDGLAVTAAGMLVMVLSLAAVLAAFPDVALRSWSGWATGLVLLSILAGTALTAGRLAARRVREAGRWRLPLALSGPLTVVLLASVPTLVSGPPASAALYGAVTLAGALLGAAWGRGRRNGRQQAGRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A6L6</accession>
    <name>A0A1H6A6L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44368">
        <property type="protein sequence ID" value="SEG44368"/>
        <property type="gene ID" value="SAMN04489712_105248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="7124" checksum="E32EB6D0D781F84A" modified="2017-01-18" version="1">MTPEDRLRAVLHAHAARVEPGRDGLERIRAGITRRPRWRRLIDRMKKARAGATARAQSPTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A8Y6</accession>
    <name>A0A1H6A8Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44921">
        <property type="protein sequence ID" value="SEG44921"/>
        <property type="gene ID" value="SAMN04489712_105278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044000">
        <property type="entry name" value="Phage_tube_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18906">
        <property type="entry name" value="Phage_tube_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="36385" checksum="984729EE21B76F72" modified="2017-01-18" version="1">MGTRSGLDAQLGFAAESVYGTGVVPSRFLEFDEEDLRETPTWLEGEGIRAGRKYKRSSRLSISRFDVKGKVDLKAPSKGLGLLLKHMIGSSATATQIASTTAYKQIHTPGDHVGKSLTWQVGRPEPGTGTVRPFTYLGCKCLSWELSVSDGEHVKLSTNWSGREESTSTGLAAASYASGAGLYNFSHASLKLGGTASTSSGEMSVSGGSAVTTVINSISIKGENPMADERYGIGNSGRKSEPLENDYPTLTGSLDAEFSKAELYDVFKSADSIPLELVFAFGDAGGGNPFELSFIGPAITMKEAAPSVNGPGLVRMSTEFEVYDDETNAPYQFRYVSTDTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABM4</accession>
    <name>A0A1H6ABM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45146">
        <property type="protein sequence ID" value="SEG45146"/>
        <property type="gene ID" value="SAMN04489712_105288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG45146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="113" mass="12622" checksum="23AF964F1C70FCDF" modified="2017-01-18" version="1">MHEPTTGELSRSLADAKTDFRERSAALSARIDTMTPLALYQAHVEGARREHDELAADIAALSARLDAEREQRENAERQRAADRRMTLTAIFTALLAPLALMLLQFYVISRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AMF3</accession>
    <name>A0A1H6AMF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_105528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49360">
        <property type="protein sequence ID" value="SEG49360"/>
        <property type="gene ID" value="SAMN04489712_105528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="128"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG49360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="385" mass="42664" checksum="2450B1E468DB5451" modified="2017-01-18" version="1">MTKLDFSMGDSAAALRVRLREMVGEHLPEGFLGAFTDDPKDLATTQKFSRTLAREGLLTLAWPREYGGADGSVWEQTVVREEMWAHHEPRGAQYMGLNWVGPAIMAYGTAEQKNRHLPPIAAGETIWCQGFSEPESGSDLASLQTRAVRIEGGWKISGQKIWTSYAGMAAWCVLAARTGDKDSRHRGISLFLVPMDRPGITVRPIRSMLGPHHLNECFFDSVHATDDEVLGAVNEGWAVIRHALAHERIGIARYARCERLLWSARSSIGEEWAGLPESLRDRWADALVQTRVARLLAYRTVEEQQLSDRVDRQASQARIASTTCDQMVAEVLAELLGGRSLLGPAGEAPLHGAFEDHWRYAQAATVASGTIEIQREIVSRELLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWN3</accession>
    <name>A0A1H6AWN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53021">
        <property type="protein sequence ID" value="SEG53021"/>
        <property type="gene ID" value="SAMN04489712_10668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="117" mass="12348" checksum="10075C9664E41D91" modified="2017-01-18" version="1">MLFRCAVLGLSPQTSAFRSGCVAAWIAFCVMGLPPLDERRGRRVLAGLARNPSVPEKVLLRLIHSSAACAVASRRADITEALAGELLGSEDVEVALPRLQHSPSDGRSPAAGRASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZ98</accession>
    <name>A0A1H6AZ98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53931">
        <property type="protein sequence ID" value="SEG53931"/>
        <property type="gene ID" value="SAMN04489712_106126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG53931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="177" mass="18652" checksum="19975B12F5BC696B" modified="2017-01-18" version="1">MTGPDKEVAAASRTSSTTVYTVPALDEAAALLADLYAAGDGHGILPDDWAGPGADLPGIALRVVAARYRRAHSRRSAREVEAMYKRMKAALSETGVTPVGVHKGRIVLPRLDTTPPWGWSGEAALTVGFYPGDGWTLELAQARTPVIDVVAPTEAAVAALVADILTGRRSDPLFPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B209</accession>
    <name>A0A1H6B209_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type nitrate/sulfonate/bicarbonate transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54257">
        <property type="protein sequence ID" value="SEG54257"/>
        <property type="gene ID" value="SAMN04489712_106146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="65"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG54257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="338" mass="34986" checksum="73C190249969F976" modified="2017-01-18" version="1">MGRYACCPAPTVTAVAARAGFLAAEFGPDGPPVPTPRDPVPWGPGGHPGPGTAGLIQESGNVPALRARAHGAPTRLVAISWADEYQAVLARPDSGIGGPADLAGRTVGVPGSPGRRAGLAGVTALRGFDRALRLAGLGLDDVRVRTLPDRTGDGLGVEDEPGVDDHGPAAAALADGTVDAIWVRGTAGLAVRRALRAVEVAALGDHPDPFIRVNNGTPRALTVHAALLADQPELVARHLAALLRAARWTRAGGAEVAQVMAAETGDPAYVHRPRTDFAPDLTGEHLAVLAAQSAFLELHGFINAHVDLGCWTDPRPLQRAWELAADPFPMPDRCRTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2X4</accession>
    <name>A0A1H6B2X4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55201">
        <property type="protein sequence ID" value="SEG55201"/>
        <property type="gene ID" value="SAMN04489712_106212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293420" description="LTD domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG55201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="765" mass="80150" checksum="F6705A5F09A6AC39" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BD73</accession>
    <name>A0A1H6BD73_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Uricase</fullName>
            <ecNumber evidence="5 7">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_1075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>H2O + O2 + urate = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 7"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58612">
        <property type="protein sequence ID" value="SEG58612"/>
        <property type="gene ID" value="SAMN04489712_1075"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="PTHR42874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG58612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="32202" checksum="2AE4B72D56279F0D" modified="2017-01-18" version="1">MGIVLGPNRYGKAETRLVRVVRDGETHHLKDLNVSVALSGEMTEVHLSGDNAAVLPTDTQKNTVFALARKHGIGSAEAFALLLARHFVTARPTVHRAVVTVEEYAWDRVPVTGHSFVRRGQEVRTARVLHEAGRTHVVSGLRDLTVLNSTASEFRGFVRDEYTTLAETGDRVLATDVRAEWRHRDADGDWESSYAETRRILLETFAGTYSRSLQQTLYTMGRRVLEERPELCEVRLAMPNKHHFAVDLEPFGLDNPGEIFFAADRPYGLIEGAVLRDDAPAADEEVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BEI8</accession>
    <name>A0A1H6BEI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 4">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_10711</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 4"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58677">
        <property type="protein sequence ID" value="SEG58677"/>
        <property type="gene ID" value="SAMN04489712_10711"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="9">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="8">
        <location>
            <begin position="175"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="324"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG58677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="397" mass="41877" checksum="5D2C3B06AD0B5317" modified="2017-01-18" version="1">MVYIACAPPPAAPWGQAQQVMTTEDMVKVGIPREIKNHEYRVAITPAGVHELTRHHHDVFVERGAGLGSSITDAEYTAAGAKILDSADEVWGEAELVLKVKEPIADEYHRMRAGQTLFTYLHLAASRSCTDALLKAGVTAVAYETVQLPDRSLPLLAPMSEVAGRLAPQVGAYNLMRFNGGRGVLPGGVPGVAPARVVVIGGGVSGLNAAQIAVGMGADVTILDVNVDRLRHIDAIYQGRLKTLVSNAYTVEQQVAGADLVIGAVLIPGAKAPTLVSNDLVARMKPGSVLVDIAIDQGGCFEDSRPTTHADPTFQVHESVFYCVANMPGSVPNTSTYALTNVTLPYAVAIANKGWRQALRDDAALARGLNTHDGTVTYAEVAEAHGLDHVGVDSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BF36</accession>
    <name>A0A1H6BF36_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">SAMN04489712_10727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58856">
        <property type="protein sequence ID" value="SEG58856"/>
        <property type="gene ID" value="SAMN04489712_10727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG58856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="118" mass="11890" checksum="ECE3DDB237930C89" modified="2017-01-18" version="1">MTVLLVALGAAVGAPLRYLADRLVQSRHESSFPWGTFTVNVVGSALLGFLAALPAGEGFTALGGIGFCGALTTYSTFGYETLRLAENGARTLAFLNVAASVAAGLGAAYCGMALASAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BF79</accession>
    <name>A0A1H6BF79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol-disulfide isomerase or thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59398">
        <property type="protein sequence ID" value="SEG59398"/>
        <property type="gene ID" value="SAMN04489712_10766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="50"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG59398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="18642" checksum="586B61520E7EE8C7" modified="2017-01-18" version="1">MTTATAAATIVGALCLINIVLTLGVIRRLNELGRLPARSAGSAAPPPLEVPPGDRVGDFTVTAVDGELVSRADLKGSTLVAFMAPGCPSCEHSLPEFLSRAEAAPGGRDQVLAVVLGDMPDSGQMREQLAPVARVLVEQEEQGPLVRAFGVGALPAYALLSGDTMVASYASVERIPDTIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNC4</accession>
    <name>A0A1H6BNC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62170">
        <property type="protein sequence ID" value="SEG62170"/>
        <property type="gene ID" value="SAMN04489712_107278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG62170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="147" mass="15347" checksum="D629CC58482C686B" modified="2017-01-18" version="1">MHHTASPNLQAMFEAVRSGASTDEIEGVEVVARPALTASAVDVLEADGLVLGTPVNIGYISGALKHFFDQIYYPCLEATVRRPYVAYLHGGSDATGALRAIETITTGLGWRAVRPPLVVTGEPGKADLEDCWELGAVAAAELAGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BYD9</accession>
    <name>A0A1H6BYD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, GT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65708">
        <property type="protein sequence ID" value="SEG65708"/>
        <property type="gene ID" value="SAMN04489712_108127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="30593" checksum="F0ADDAC3042FCF54" modified="2017-01-18" version="1">MNERMTVVIATRDRRAELLRTLKHLTAPAGEPAVIVVDNASTDGTARAVAAEFPGVQVIRLPENLGAAARTAGVQAARTPYVAFSDDDSWWEPGALRRAAEVLDAHPRLGLVAARTLVGPERTDDPINAAMADSPLGAAAGLPGPPVLGFLACASVVRRRAFLEAGGFDPVLFFVGEERLLAMDLAARGWGLAYVPDVVAVHEPSAHRPPSGRRLRAELRNTLLTAWMRRPARVALGETARLAGAAARNADARAALAGALGRLPAALARRRRLPPHVERDVRLLETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C036</accession>
    <name>A0A1H6C036_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_108133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65766">
        <property type="protein sequence ID" value="SEG65766"/>
        <property type="gene ID" value="SAMN04489712_108133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="118"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="372"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG65766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="541" mass="58729" checksum="BA98DC60B685097E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C173</accession>
    <name>A0A1H6C173_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted ATP-dependent carboligase, ATP-grasp superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66467">
        <property type="protein sequence ID" value="SEG66467"/>
        <property type="gene ID" value="SAMN04489712_108195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG66467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="287" mass="31434" checksum="72814D0612096E25" modified="2017-01-18" version="1">MVEFENVPELVDPVLVAAFEGWNDAGEAASGVIRHLESAWDASPVAELDPEDYYDFQVTRPTVELDEDGVRSITWPTTRISWARPPGSSRDVVLIRGIEPNMRWRSFCRELLEAVERLGVRTAVLLGALLADSPHTRPVPVSGSVSGPPVVGTLRLEPGGRYELSRYEGPTGILGVLQDACDKAHIGTVALWASVPHYVSHPPSPKATLALLRRVEDLLDLTVALGELPEEARAWEHGVNELAEQDTEVAEYVKALEEQKDAAELPEASGDAIAREFERYLKGRDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7G1</accession>
    <name>A0A1H6C7G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrogenase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68848">
        <property type="protein sequence ID" value="SEG68848"/>
        <property type="gene ID" value="SAMN04489712_10925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG68848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="597" mass="67490" checksum="77016CA5345A7DC6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CBE5</accession>
    <name>A0A1H6CBE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_109158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70291">
        <property type="protein sequence ID" value="SEG70291"/>
        <property type="gene ID" value="SAMN04489712_109158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005876">
        <property type="entry name" value="Co_trans_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01166">
        <property type="entry name" value="cbiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG70291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="28492" checksum="74A8FEA2D9ABE330" modified="2017-01-18" version="1">MTAVLSAHDVAYAYEGADPVFAGLSLDVAAGRSLALLGPNGVGKTTLLRLLTGGLRPARGEIRLDGSPVSYSRRGLTELRTRVQLVLQDPDDQLFSASVTQDVSFGPVNLGLPADEVRARVVEALAAMEITELADRPTHLLSFGQRKRVAIAGALALRPAVLVLDEPTAGLDPSGVEALLATLADLQAADTTIVASTHDVDLAHRWAQDAAVLAGGRLHTGPAAGLLADEALLHAARLRPAWGPAVGRLLRRHGILPADAPDPRTPADLAATGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CBF5</accession>
    <name>A0A1H6CBF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70117">
        <property type="protein sequence ID" value="SEG70117"/>
        <property type="gene ID" value="SAMN04489712_109143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG70117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9644" checksum="282F9BCD3075439E" modified="2017-01-18" version="1">MSIPSDPLTERERQAVLLAHDVHDHLLHWLTRHGVACPLVVSPFVDATGQPSVLLRLNSPAARTLLRALTLPAPPSNPRNVQRRDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEW3</accession>
    <name>A0A1H6CEW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_109217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70886">
        <property type="protein sequence ID" value="SEG70886"/>
        <property type="gene ID" value="SAMN04489712_109217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041674">
        <property type="entry name" value="TetR_C_22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17928">
        <property type="entry name" value="TetR_C_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG70886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="184" mass="19980" checksum="01B1F692B3AFF89B" modified="2017-01-18" version="1">MLDACAEILDESGYDGLSTTRIAQRAEVAIGSVYQFFPDKRAVAQALALRNLETFGERVSRLLAEESFAHWSDTVGAIIDIFVDMNRTVPGFRVLRFGDVADVNLLDESADNNSVVAERLRLLIVGVFGVADTPETARAISIAVEAADAVLKMAFRRDPDGDPAVLAEAKRLIHGYLAGHIDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJY4</accession>
    <name>A0A1H6CJY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72716">
        <property type="protein sequence ID" value="SEG72716"/>
        <property type="gene ID" value="SAMN04489712_11029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG72716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="170" mass="19320" checksum="1C4307E0AA54AC3B" modified="2017-01-18" version="1">MEDSVDRHIARWRGLTPFDDRAEGIITRIQFLAKHVGQTKDRALAEVGLQESEFETMHRLVSRGRPWRAGPSELAAELMLSPAGMTGRLDTLERAGLVRRLRGTGDRRRVEVELTEFGHDRWQEAMRLRGEAEEAMLEGLDEADQEALNALLKRMLVRAEALFRDAGPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUI8</accession>
    <name>A0A1H6CUI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serS</name>
        <name evidence="10" type="ORF">SAMN04489712_111194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76690">
        <property type="protein sequence ID" value="SEG76690"/>
        <property type="gene ID" value="SAMN04489712_111194"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="145"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="236"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="265"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG76690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="427" mass="47677" checksum="D5490E3B79FC1647" modified="2017-01-18" version="1">MERTGSLGSVIDLRALREDPERLRASQRARGEDEAVVDRLIELDGRRRAALSRFEQLRAEQKSFGKSVSKAKGEERQALLERAKELAQQVKEAESEADRLAEELDGLLRTVPNIIEDGAPAGGEQDFVVLEHVGEPPSFDFEPRDHLELGERLGAIDTERGAKVSGARFYYLTGVGARLQLALLSLAMEQAIEAGFVPMYPPVLVKPEAMEGTGFLGAHAAEVYRLPDDDLYLVGTSEVPLAAYHMNEIIDELPRRYAAWSSCFRREAGSYGKDTRGIIRVHQFDKVEMFSYCAPEEAHAEHLRLLDWEKQMLAKVEVPYRVIDVAAGDLGASAARKYDCEAWVPTQHAYREVTSTSNCTDFQARRLAVRHRDESGKARPVATLNGTLATTRWIVAILENHQQPDGSVRVPKALQRHLGLEVLEPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CUY7</accession>
    <name>A0A1H6CUY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein YndB, AHSA1/START domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76899">
        <property type="protein sequence ID" value="SEG76899"/>
        <property type="gene ID" value="SAMN04489712_111222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="18161" checksum="1FD0049229D87AC6" modified="2017-01-18" version="1">MGSETTTVTTEGTELVMERVFNAPRELVWAAFTEAEHVRRWWGPKGTTVTVVEMDVRPGGTWRYVTHGPDGQDAPFKGEYLEVVPNERIVRTFVFDVEPFNDHSAVETLTFEDLGGRTKVSTRSRYSSREALDGALAAGMEQGATETYDRLADILTELTTGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV11</accession>
    <name>A0A1H6CV11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76355">
        <property type="protein sequence ID" value="SEG76355"/>
        <property type="gene ID" value="SAMN04489712_111153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295235" evidence="2">
        <location>
            <begin position="34"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="316" mass="33025" checksum="1A0414C74BDF5D42" modified="2017-01-18" version="1">MNTPTKLGAYVLGLAAVFAGAVGVGDVAGPATAKTEAKASDGHGAHGTPATAPAGPISGGLQVTQDGYTLVPRSVTVPAGEKTDFTFTVNGRDGRPVTRFATLHGKKLHLIVVRRDLSGFQHLHPTENGAGVWSIPLTLPDPGAYRMFTDVQPEGAARQLTLGVDVTAPGDYRPEALPKAEQTARVDGYEVKLEGTLVPGRTSKLTLTVHKDGRPVTDLEPYLEAYGHLVALRSGDLAYLHVHPDGSPGDGRTRPGPQITFYAEVPSSGAYRLYLDFQHGGKVRTAEFTAVAGHGEIPAAPAPAPADDGHGHTHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVX6</accession>
    <name>A0A1H6CVX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylamine utilisation protein MauE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76998">
        <property type="protein sequence ID" value="SEG76998"/>
        <property type="gene ID" value="SAMN04489712_111235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="31658" checksum="21941BBD592EA345" modified="2017-01-18" version="1">MIDPAVDAQVLLLAMVLAGAGLAKLLVREPVPVRPPPVHGVPEPPAATGWAVTLRRSRPVAAGLGLAEVTLGAGLMLCPYPAVRAAAATLLAAATWVVAELRQRTPDAGCGCFGGLSDERVGLRDIARTALLAAAAFATLGATDTGVQIARTGPWQVWALCGLELALLAALSPEPAALLRRRQRPTVPCERRRSPLTETYATLRRSDPWRRHRHMLDGGDPLDVWREGCWRFLAYSAHQNGHQVEVVFAVSTAHRNRTVRAAVLPTEPPIHPNATHAESPAIEDTEESGPHYIMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0X1</accession>
    <name>A0A1H6D0X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79001">
        <property type="protein sequence ID" value="SEG79001"/>
        <property type="gene ID" value="SAMN04489712_112152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="64"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="494" mass="53582" checksum="BB8F45A7172AD791" modified="2017-01-18" version="1">MERQGDEQVCPACRTTRLSRYNPNPLCGVCLANVRDGAGIVPVWLWDSGPLRQALARADMAAVLAILRAAAGMSQLEFGQLLGWSQSVVTKIERRKRDTFHDVREILRVADLLEVPRQALLPLILGRPDIELESDEDAASWGDAVQPGRELDRRQFAVMASGLALGAVLPAPKRVDRGHVRYLRACLEQLQDQDRIIGGASLRAQALRLFGRARAMLDESDYTEQVGRELLVVTADLGVVAAWLAYDSGDQATARALYGEAELMAGSAADNELLVHVYANMAQQATHLARITERRGRAREALRFADRAADAARHLPSPALHALIALRQAGAHAQLGDAVAFRASIGQARREIDRGQHETDQNWTGFVTHSEITAYEAMGAFQLGRPDTAAGLYQMVLEDCRRSPRDQVYFRARPAATLCAAGDRQGAVTEGLAVVGDLGSKLTSVRVLNELRPVRQAAGASAEEFCERFDAAVRILAPPSTGRAGHVPVGGSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D159</accession>
    <name>A0A1H6D159_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase (Glutamine-hydrolysing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78824">
        <property type="protein sequence ID" value="SEG78824"/>
        <property type="gene ID" value="SAMN04489712_112129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="208"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="609" mass="66847" checksum="3C15048B2BFEA53A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D251</accession>
    <name>A0A1H6D251_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase YjhB, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78963">
        <property type="protein sequence ID" value="SEG78963"/>
        <property type="gene ID" value="SAMN04489712_112147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="16420" checksum="44197EB71DF3A5B6" modified="2017-01-18" version="1">MTTGIAAPQTAAHAVLTDHRGLVLLVNPAYKNRWHLPGGYLRPGELPSAAVTREITEELAITPALPPAPAVIAWAPHGGDRLLLYYAAELNTEQARSMQIDGHELVGFRWCAPTALDEWLHPAIADRARLALEASRRGQTLFLEPHRPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3Y2</accession>
    <name>A0A1H6D3Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase, propanol-preferring</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80042">
        <property type="protein sequence ID" value="SEG80042"/>
        <property type="gene ID" value="SAMN04489712_1133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08298">
        <property type="entry name" value="CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014187">
        <property type="entry name" value="ADH_Zn_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02822">
        <property type="entry name" value="adh_fam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="34211" checksum="A676F47A585FA4BD" modified="2017-01-18" version="1">MTAPGPMASGPLRPVDRELPVPGPGELLLRVRACGVCRTDLHVAEGDLPVHLPGVTPGHEIVAEVVATGPGCLHSPGDRVGVAWLRHTCGSCTYCRRGAENLCPRSLYTGWDAHGGYADYAVAPDAYVYDLPAGRTDAELAPLLCAGIIGYRALRRAELPPGGRLGIWGFGGSAHLAAQVALAEGAEVHVFTRAPAARTLALELGAAWAGDSFDASPAPLDSAIVFAPAGELLPAALERLDRGGTLAVAGIHLTDVPVLNYQRHLFQERQVRSVTANTRADGQEFLRLAGRLPIKVSTTPYDLSDADRALADLAADRINGAAVLLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D491</accession>
    <name>A0A1H6D491_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80157">
        <property type="protein sequence ID" value="SEG80157"/>
        <property type="gene ID" value="SAMN04489712_11328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="157" mass="16995" checksum="D80F281B8CC52714" modified="2017-01-18" version="1">MDLPQGDVRLLGSEVAGRLLASTELARLAYVAADGTPRVFPMMFHWNGEEIVMATFGGAHKIPALRARPDVALTVDTPGPPPDVLLIRGRAQVTDVAGVVPEYGLIHRRYFGEEQAAATVAEIDRPGLTMARIAVRPTWAGVLDFQTRVPRALAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D739</accession>
    <name>A0A1H6D739_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PASTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_113154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80798">
        <property type="protein sequence ID" value="SEG80798"/>
        <property type="gene ID" value="SAMN04489712_113154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295583" evidence="2">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="70"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG80798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="145" mass="15710" checksum="55F953A98799C1C9" modified="2017-01-18" version="1">MRRRSYLPALTLAVLASACQSAGDAEAKPAATVTVTRTVPPASTATDAPGSSEKPTTGEPDPTDENSEPAAGKRRLPNVVGMNHQEAQDRLQAAGFRRLSEEDATGRNRILLWDRNWVVVDQIPKPGSRIPLDTRIILRSKKLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9C1</accession>
    <name>A0A1H6D9C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81829">
        <property type="protein sequence ID" value="SEG81829"/>
        <property type="gene ID" value="SAMN04489712_114153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="52" mass="5339" checksum="E2207545A0BF3974" modified="2017-01-18" version="1">MLASLSLTDPVEAHLNGKVAALDAAWRQMAARLAEAGDDSLVKVAASPGTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBM4</accession>
    <name>A0A1H6DBM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82688">
        <property type="protein sequence ID" value="SEG82688"/>
        <property type="gene ID" value="SAMN04489712_11564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="30289" checksum="B6E6F22F732C5169" modified="2017-01-18" version="1">MPDQPPKTVIISGGTTGMGRAVALERLARGDHVTVIGSNEARGRALLDRAAGPNLRFLRADLSSIAEVERVVADISGQHQAIDALALFANRISPKYNETPDGLEFTFALYYLSRYLLGHRLRPLLDAAPNPVIINVAGVGNTAGKIFWDDPQLTRRYGQVRAQLQAGRANDLLGVAFAGQTESKIRYILYHPGFTRSGSDAHSNPLIQNTIELLARFFARPVVDAVRPIVEWIDHPPAGALSAIDRGKPVDLSLKTLNPDDAARLAAYTQDLLRSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DC24</accession>
    <name>A0A1H6DC24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">23S rRNA G2445 N2-methylase RlmL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82363">
        <property type="protein sequence ID" value="SEG82363"/>
        <property type="gene ID" value="SAMN04489712_11515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0020" evidence="1">
        <location>
            <begin position="176"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="357" mass="38213" checksum="771799677F0A3E7B" modified="2017-01-18" version="1">MTAARLVARCVHGLEPAVAVEVLGLGAVTRLGHREVHFRMHRSGSRAVALRTADDVFLLAARRPDIGTAKEGLAALADLAATADTGRLLRLREEHGGPGRLTGVEVSASFLGRRNFNRYDAEDAIGQVLARRLGTGYHSRRTGVAPPPTHSGWRLTLDGTHATLMLRIAARPLHRRTYKQHSIPGTLHPPVAAAMARMADVRPGHTVLDPCCGAGTLLIEAGLHQPQARLHGFDLSPEALRAAGQNASGLPVTLERADAARLPLPDGSVDRVLCNPPWGGQVAARGLLAGSPSRWWTELRRVLAPGGLAVVLLPDADDIATAIRRHLVPQHVQRVRLSGAQPFIAQFTAPAERGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFB4</accession>
    <name>A0A1H6DFB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell envelope-related function transcriptional attenuator common domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_116135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84058">
        <property type="protein sequence ID" value="SEG84058"/>
        <property type="gene ID" value="SAMN04489712_116135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="198"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG84058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="499" mass="53138" checksum="03960368F343BAC5" modified="2017-01-18" version="1">MAWKAVRGRGTAPGENQPPDATGARGLPGALGLTLASGLLWGVAHLWAGRRVAGILLMALYTALVTVTVVAVTLFRPELTGLAVQSDWLTRITAGLLTLGIVWAAVVIRSYQIARPFDRTAFTRTVGATAVAVLCVLVSLPLVWAAHLAQVSNDTLSSIFQAGGNGREIDRKDPWNGQRRVNVLLLGGDAGPNRVGVRTDSMTLASVDTHTGDTVLLSLPRNLESFPMPPGPARDRFPYGFTGDGPQTPGLLNEVYEYAENHPDVVPGVPKKQRGPELIKGTFAGILGVPVDYYILVDMQGFADLIDAMGGVRLTVPEDIVYGRLGEGRVKAGTRTLSGKEALWYGRSRTNSDDYVRMGRQKCLLRAVARQADPQRVLTRFDQLAEAARRAVSTDIPAELLPAFVKLSSRMRDGATINSLQFVPPLISTGNPDFDLIKSLTAKAIAASEKGATATPSPSPSSSRSATPRPHASSSPHASSSPDARDQAKPVSLDESCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFB6</accession>
    <name>A0A1H6DFB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipoprotein-anchoring transpeptidase ErfK/SrfK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_116114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83969">
        <property type="protein sequence ID" value="SEG83969"/>
        <property type="gene ID" value="SAMN04489712_116114"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="54"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="242"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG83969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="42139" checksum="3D94576BE8FD6A08" modified="2017-01-18" version="1">MGDRVSGRARLWLIVTGGAGAVTVFVSGCSGGAGALSSAKEATVTITPANGTGAVKPDAPIEVKVADGTLEDVSVTGGAVPITGKLSGDRTGWKSARTLVPGTSYTVTVRTKNGDGKVASANSTFTTLRPQQTFALADVTPNVKGEKVGVGMPIIVRFDRPVTDKAAVERALEVKPEKPVEGAWRWIDPQQVIYRTKTYWQPYQKVRFTARLAGLQAAKGVYGTKDSSYTIEIGAKQVTTGNINDHHATVYRDGKKLRTMPFSAGNGTTREYTTTSGVHLLMEKGNPVKMTAPGRKEGDAGWYEQSVNHAIRISNSGEYFHAAPWSVGSQGSANVSHGCLNLSPENARWYYGIHQRGDVVKLTGTSRQLEWDNGWGYWQLSFNEWKEGSALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFH7</accession>
    <name>A0A1H6DFH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4240 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83493">
        <property type="protein sequence ID" value="SEG83493"/>
        <property type="gene ID" value="SAMN04489712_1165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025334">
        <property type="entry name" value="DUF4240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14024">
        <property type="entry name" value="DUF4240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4240" evidence="1">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="21216" checksum="25131469E9D0E4AB" modified="2017-01-18" version="1">MAHRPAVDAEEFWAIVEAARADAAPFHEALTDRLATCTAETILEFEERFDELDGAVYRWDVWATAHLIGGGCSDDGFTDFRAGLIALGRHWYARAAQSPDNLADHPDVLQTATEPRRHPVFYEQAAHAAGQAYTQVTGGNSDDFHDTWDRYRTSHGIQDTPPDLGEDFDFDDADQMHRRLPRLAALYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFP3</accession>
    <name>A0A1H6DFP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IMP dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_116134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG84054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84054">
        <property type="protein sequence ID" value="SEG84054"/>
        <property type="gene ID" value="SAMN04489712_116134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005991">
        <property type="entry name" value="IMP_DH-rel1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01303">
        <property type="entry name" value="IMP_DH_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG84054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="478" mass="50455" checksum="1582840596478579" modified="2017-01-18" version="1">MRLLNGERVAHDLTYNDVFMVPRRSAVGSRLEVDLTTTDGSGTTIPLVAANMTAVAGRRMAETIARRGGLAVLPQDIPAEVVADVIGWVKRRHLVFDTAIRLAPSGTAGEALGLLHKRAHGAVIVVEDDRPVGVVTEADCQGVDRFSQVRDIMSRDLVTLPDAVDPQEAFDRLHERGHRLAPVVDAAGRLTGILTRTGALRATLYTPATDDAGRLRVAAAVGVNGDVAGKAKALLEAGADLLVVDTAHGHQEKMIAALAAVRGLDPSVPVVAGNVVTAEGVRDLVGAGADIVKVGVGPGAMCTTRMMTGVGRPQFSAVLECAAEARRLGRHIWADGGVRHPRDVALALAAGAANVMVGSWFAGTYESPGDVQRSADGRLYKESFGMASARAVRLRTADDSPFERARKALFEEGISTSRMFLDPRRPGVEDLIDSIVAGLRSACTYAGARTLEEFHERALVGVQSSSGYAEGMPLATSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DG66</accession>
    <name>A0A1H6DG66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83763">
        <property type="protein sequence ID" value="SEG83763"/>
        <property type="gene ID" value="SAMN04489712_11663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG83763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="43458" checksum="9289254C079F3244" modified="2017-01-18" version="1">MTRADLDEFRERVRDWCRAHVPKDWRREQTGVSDEEFVSFQQEWFQELRRAGFAVPHWPAEWGGGMPVAEQVVLYQELAAHDAPRLVLAFVAIHHAASTLLAAGTDAQRRRHLPAILDGEIWVQGFSEPGAGSDLAALSTSARREGDAYVVNGQKLWASGAAHADWCLLLARTDPSAPKRRGISYFLMDMRTPGIDVRAVRQATGESHFCEIFLDDVVIPAEHLVGPENEGWRVAQRTLGAERGMTMLELAERLGNGGFRWLVELCARPGPGGARPLDDPLVADRLAALETELTGLRALCARLVADEDPGPADASIVKLYYSELLQRMTDFGAEVAGLAAHTALRKPLSSGWESGAWVLDFIGSWEWTIPGGTSEIQRSIIGERGLGLPREPRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGC9</accession>
    <name>A0A1H6DGC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase (NAD+)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83833">
        <property type="protein sequence ID" value="SEG83833"/>
        <property type="gene ID" value="SAMN04489712_11677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="13"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG83833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="478" mass="50481" checksum="4E52E8F36994A335" modified="2017-01-18" version="1">MREYLKFYIGGQWVDPAEQRTFDVVNPATEEVCGTVAVGSAADVDRAVAAAREAFATWSVTGREDRLEVLRNILGEYQKRAGDLAAALTEEMGAPAALAGGFQVGLGAGHLTTAIEVLENFAFEERRGATLVVKEPIGVCGLITPWNWPMSLIAVKVFPALATGCTMVLKPSERSPFTGQIFAEILAAAGVPAGVFNLLQGDGPSVGVPLSRHPGVDMISFTGSTRAGIEIARNAAPSVKRVTQELGGKSPNIILDDETFAENVRGGVGEMMGNSGQTCSAPSRMLVPSARMEEAIAIAEEAAAQVTVGDPTGDVVMGPVVSESQFEKVQALIQKGIDEGATLVAGGPGRPEGLERGYYVKPTVFANVTNDMTIAREEIFGPVVTILGYRDIDHAVEIANDTEYGLAGYVAGADLEQARAVARRIRAGWVVINGGFDFNCPFGGYKKSGNGREWGEFGFDDYLEVKGIPGYAPDEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DII7</accession>
    <name>A0A1H6DII7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted kinase, aminoglycoside phosphotransferase (APT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_117132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85078">
        <property type="protein sequence ID" value="SEG85078"/>
        <property type="gene ID" value="SAMN04489712_117132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="34"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG85078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="352" mass="38845" checksum="8D8506D51A4CC5FA" modified="2017-01-18" version="1">MSGRRPAEELVDLGRLNAWPQVADLPGEGPFESISPITGGAQNLLFSVRRADGTELVLRRPGRHAAGDGAAAPFARESRVLTALAGTSVPHPRLYASCLDDAVIGAPFSILEKIDGFMPRGRLPGAYATDPQWRRRLAFELVAGAATLAAVDPEKIGLGDLSKTEGWLDRQTPRYLRMLEGYREVPEYRDNESPSVGRVAEWLQANRPASGRLGIVHGDLQFANVMFAHDEPRLAAIVDWEMASLGDPLLDLAWILTAWREEGDPPGSAPQLQPWEDMPGRAELVAHYAELTGRDVSDFRWFQVLACFRLAALLEGSYVRALNGKMDRRMGEGLHTYAQWLWAKAEQEITRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIS7</accession>
    <name>A0A1H6DIS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_117146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85140">
        <property type="protein sequence ID" value="SEG85140"/>
        <property type="gene ID" value="SAMN04489712_117146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="23263" checksum="A207A242164BE52E" modified="2017-01-18" version="1">MTDVAIITGAADGIGAATARRLAAAGTRCVLVDRDPLVEKVAVDVDGIAVVGDPSDPDLSTKAVAYAGDRLDLLVLNAGTGCPGWDPATLDLRGYRSAVGLSQHAVVYGLRAAIPAMRRGGGGSIVVTAPYAEPLTAEDDPFSMMTAYAVLGLVRAFARPLAREGIRLSVVCPGRRDDAGAGFPGLDGAAPDSDEVAAVVEDALRAAAPGSRLVVRPGALLVSHAAAPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLI1</accession>
    <name>A0A1H6DLI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_118125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85991">
        <property type="protein sequence ID" value="SEG85991"/>
        <property type="gene ID" value="SAMN04489712_118125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="561" mass="56578" checksum="23106512F06455C1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DM01</accession>
    <name>A0A1H6DM01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86171">
        <property type="protein sequence ID" value="SEG86171"/>
        <property type="gene ID" value="SAMN04489712_1195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="31" mass="3258" checksum="8C7B22960171D921" modified="2017-01-18" version="1">MALKHYPEEFKADAVALGASPSVVDTLRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMG6</accession>
    <name>A0A1H6DMG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_119116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86577">
        <property type="protein sequence ID" value="SEG86577"/>
        <property type="gene ID" value="SAMN04489712_119116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="11327" checksum="F82A7D1BC02D3BF3" modified="2017-01-18" version="1">MDGANLGEAYLGSVNLSDAKLHNATLEGADLYRANLRGAHLHEALLGDAKLINMNLRNADLRGTGLTEDKARSIPTRINEQLDHPESAGVGKWCSLLAAPARTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMU9</accession>
    <name>A0A1H6DMU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_119133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86640">
        <property type="protein sequence ID" value="SEG86640"/>
        <property type="gene ID" value="SAMN04489712_119133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="12"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="311" mass="32534" checksum="DD7D6F06BC67FE5D" modified="2017-01-18" version="1">MKITKLADGLLFPEGPVALPNGDVLVVEIHRGTLTRVAPDGTTSVVAEVGGGPNGAALGPDGRVYIANCGGMHRFEVGGFVFAGGIPADYTSGSIQAVDLSDGSVETLYTKDDDGRDLRGPNDLVFDAHGGIYFTDYGKSDGDTCDKGRIYYAKADGSSCKTIAAGMEGPNGIGLSPDGERLYVSETYTARVWWWDVTGPGQIVGGKSLGGSGNGNFLYTAPNYVNFDSLGVDAHGNVNVASMVNAGISVVGPDGKLVQFVKIDVDDDPGITNICWGGKDMRTAYVTASSTGQLLKIEWPRPGLKLNYHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DP34</accession>
    <name>A0A1H6DP34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="5" type="ORF">SAMN04489712_12057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87040">
        <property type="protein sequence ID" value="SEG87040"/>
        <property type="gene ID" value="SAMN04489712_12057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="4">
        <location>
            <begin position="95"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG87040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="18100" checksum="2D242D0D2B8F3345" modified="2017-01-18" version="1">MDDQVVVGRIGRPHGIRGEVTVDVRTDDPDVRFAPGTVLATDPGQAGPLTVEQARWHSGRLLLRFAGVDDRTAAEDLRGTWLVVDAGDLVPLSDPDEFHDQELIGLTAVTTGGGTVGTVTEVRHFGQDLLVIRRDTGGEALVPFVAALVPEVDVAGGRLVIDPPPGLLDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTG8</accession>
    <name>A0A1H6DTG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crotonobetainyl-CoA:carnitine CoA-transferase CaiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88540">
        <property type="protein sequence ID" value="SEG88540"/>
        <property type="gene ID" value="SAMN04489712_12226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="410" mass="44304" checksum="A63235E486FFB82E" modified="2017-01-18" version="1">MHRPMEGVRVLEVAQFTFVPAAGAVLADWGADVIKIEHAERGDAQRGLVRLLGLDVRSRNTSFFPIMEGPNRGKRSVGLALENPSARRVLEELVRTSDVFLTNFLPGARAKLRIDVEDIRAINPDIIYVRGTGFGSRGEEADKGGYDSTAFWARGGSAAGVTPPDSDTMMRMPAGAYGDSIGGMTIAGGIAAALYSRQATGEPSVVDVSLIGVGAWATQFSVNLALMAGGPLPEIKQPRHGSPTNPLIGAYRTADGRWLEMAMLQPGLYWPEFCTVVGREDLISDERFAGVEKIMQNAPAAAGLVAEIIEQRTYAEWVELFEGMQGQWAAVQNSWEVGQDPALRANGLIAPVIDADGKRRELVANPVQFDETPPELRRAPQFAEHTDEVLRQLGLSDEELIALKLDGAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUA8</accession>
    <name>A0A1H6DUA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88175">
        <property type="protein sequence ID" value="SEG88175"/>
        <property type="gene ID" value="SAMN04489712_12191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="35"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="16570" checksum="A59AAF1B790AA91B" modified="2017-01-18" version="1">MTRADLPARAGSAGVRFLEVVRFPAEDDAPDASVNVREVRAYLREALDGAGVDLGDVDLMAAEIVTNAVLHTASGRPGGRVWAAVIATDEVIRVEITDQGGAAGEPRVPAYAVLGGRGLLIVRELAARWDWARDDAGHTTVWFEVPRTGGTAGWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUJ8</accession>
    <name>A0A1H6DUJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkylated DNA repair dioxygenase AlkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89027">
        <property type="protein sequence ID" value="SEG89027"/>
        <property type="gene ID" value="SAMN04489712_1233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="23556" checksum="E3E09BBEA81FDBE5" modified="2017-01-18" version="1">MTPPFQGSLLTCDDEVHPGPLGALVRRTPLAHGAWIDLRPGWIGGADTLFQRLLHRVPWRAERRRMYERVIDVPRLLAFYDEHAPLPDPALDEALRILNDHYAPELGEPFRTAGLCLYRDGRDSVAWHGDTIGRGRTEDTMVAILSLGTPRPLLLRPRIGATAPLRHNLGHGDLLVMGGSCQRTWEHAIPKTTRPTGPRISVQFRPRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DX40</accession>
    <name>A0A1H6DX40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89145">
        <property type="protein sequence ID" value="SEG89145"/>
        <property type="gene ID" value="SAMN04489712_12330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="26198" checksum="6E1DE27FE87A0678" modified="2017-01-18" version="1">MDAASRAGDSAAGAGYAGKVAWITGGAGGIGAAVARRLAAAGARVLVSDIDAERGNELAGEIDGAFVRCDVRDPADSTAAVAAATDRFGGLDIAFLNAGVTGDCGLGRDFDPEAYRRAMAINLDGVVYGVAAALPALRARGGGDIVATASMAGLTATPFDPIYGANKAAVVGLVRALGPNHLPEGIRINALCPSFADTDIITDIKEHLEQTGFPILEVSDVVTAFMQILASDGAGEAWYVVPGRPSEPFKFRGVPGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXX3</accession>
    <name>A0A1H6DXX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclohexanecarboxyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90039">
        <property type="protein sequence ID" value="SEG90039"/>
        <property type="gene ID" value="SAMN04489712_12521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG90039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="381" mass="40029" checksum="E963A956DF3B82B9" modified="2017-01-18" version="1">MDFAFSPDQEALAKRIREFTAERMAPLAAEADRTGRFRDGLFAELAAQELFALGVPAAYGGRGADSVSLGIALEELAAGDLTPCYAVLNAALIGAILDGNATPEQCRRWLPAVAAGESVLALCLTEPGHGTDAASVEMRAEESGSGWVLHGVKTSTMLGAYATHGVVFARTGGPGARGVTAFFTPLDAPGITRTPLHDLGSRAGGRSTLAFDGVAVGADAVIGGPGLGFVQVMRGFDYSRALIALMAVGAASASLREALDHARVRETFGRPIGTYQGVAFPLVEHATALHMARLVAYEALWRKDAGLDHRMEANMAKWWAPKAAVDAAHQALLTFGHQGWSEDLPIARRLRDLIGTELGDGTAGATRLVLARRLLGREHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYZ7</accession>
    <name>A0A1H6DYZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90204">
        <property type="protein sequence ID" value="SEG90204"/>
        <property type="gene ID" value="SAMN04489712_12568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG90204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="421" mass="47379" checksum="7E597B44DFF6E09D" modified="2017-01-18" version="1">MVSVVTSEAVPETSEAAAVRDSIELFTGGGGLALAMHNAGFRHLLAVEFDRRACQTLRSNVATEHGPEVPNPDSVTDKWPLYEGDIHNVNFANAMGKVDVIAGGVPCQPWSLGGAHKGYEDKRNLWPELFRCVRETRPRAVIAENVKGLLRPSFAPYYEYILNELRAPLEERVDGEDWQDHNRRIMKALKSPGQDLKERYDVKYFLVNAADYGVPQVRWRVFVVAFRKDLGLSEWEFPKPTHSEAALLREQETGEYWDRHGIKPRETGVQASILDGGGLKPWRTLRDALRNDPDAPHLKPLPEPRRPLEDKIEHPDWLHHFGWPGAREYAGHTPNLLDRPAKTVKAGVHGVPGGETVIKLDDGSIRYMTVREVSRVMTFPDDWRLEGPRGEQMRQLGNAVPVRLGEVVARSVAEALKPKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZD2</accession>
    <name>A0A1H6DZD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90193">
        <property type="protein sequence ID" value="SEG90193"/>
        <property type="gene ID" value="SAMN04489712_12565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="179" mass="19821" checksum="BE36E8EAA5B6FE0E" modified="2017-01-18" version="1">MRVDARSSAPDRAMGEMTINDRSLNLVRISRTVYIVYMKPDDTFWREVSGRKSVNKLSGKYLKATVDDMNLKELTAFMDYKGMLGKMLRSAGTVTKGTLAMINWNPAITLKDRVIGDVHVATIGRPYVLQIESRDDKEQLDFTGHGVPVNVTSPPPNMVTDIDVLRKLVGGTGHLPLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0I9</accession>
    <name>A0A1H6E0I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90714">
        <property type="protein sequence ID" value="SEG90714"/>
        <property type="gene ID" value="SAMN04489712_12717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="319" mass="33772" checksum="483AF18C27564C8A" modified="2017-01-18" version="1">MFAPDVVAAVLTGGLVGGGILLLAMAIRGVPVRPGRPTRRRSREELVRTLTTRTAVAAIIGAVVLVVTRWPVAAVGAGLLVLGWEGIAGGAAEERRAMARLEGLAAWTESLRDTIAGAVGLEQAIPASVRAAAPALQQPLRTLVDRLHTRMPMPEALRRFADDLNDPSADLVIAALILNARLRGPGLRDMLGALSTSARAELDMRRRVEADRKATRRSVNIVVGVSVGTALLLAVFNRAYVAPYDGLVGQLVLVVVLALYAAAFLWLRRLARYDMPQRLLSTPDTAPGVPREVPATVAGWQGATPPLRGRHAMDAGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0T5</accession>
    <name>A0A1H6E0T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS system, mannitol-specific IIB component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91228">
        <property type="protein sequence ID" value="SEG91228"/>
        <property type="gene ID" value="SAMN04489712_12867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="10578" checksum="1073135E2AA721C8" modified="2017-01-18" version="1">MTTINGKDVRKLVIACDAGMGSSVMLAGQLRRALKKEQVVVEHTPVDSIPADADVVVCHTGLADRARRGAPGKVVVPFQVYLGDPAVDGVVTAIRDGGVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1J5</accession>
    <name>A0A1H6E1J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase, MSMEG_4879 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91480">
        <property type="protein sequence ID" value="SEG91480"/>
        <property type="gene ID" value="SAMN04489712_12930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019910">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_4879"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03564">
        <property type="entry name" value="F420_MSMEG_4879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="301" mass="31132" checksum="D9D13635D16F2D98" modified="2017-01-18" version="1">MVWATGTPEGFVADVADAERAGFAAVWTPQVFGWDALTLLALAAGATERIELGTAVMPIYPRHPLALAASALTTAAAADGRLTLGIGPSHRFIVEDIWGLTYDRPFSYTRDYLDALLPALAGEPTDVATELVTARTARPLDTPQAPEPPVLLAAMAPRMLALAAARCAGTITWLAGIGAIRDTIVPAITEAAAAASRPAPRVVAGLPICVTDNPRRARDRAAQQFAPYADVPAYRRVMAKDGATGPADVAVVGSAAEVADRLAELAEAGATDLMAMPFGDPAEEAATCEVLIGLAAEQSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1T9</accession>
    <name>A0A1H6E1T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91542">
        <property type="protein sequence ID" value="SEG91542"/>
        <property type="gene ID" value="SAMN04489712_12954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="72"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="26330" checksum="C07291514D16147B" modified="2017-01-18" version="1">MVNTAGRAGSPAVHRATRILGELAMHDEPLNVSELSRRVQVPKSSLSDICKVLVDGGMLSRGLDGGLRLGPGITRIARGLVGGSRLLEVFPRICAGARELDGRTVVLAVLRDLDAAYVAVRPGDRPLSLTLKPGMRLPAWSTGTGRALLSALPVDVVERMHSGPVPESPSGHRFRLKDLTAAVTLAQSRGYASSAELGEMSLTGTAALVEGLHGCIAAVGSIADGTRSDEPSPADDSVPIRALAARLATAIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2M2</accession>
    <name>A0A1H6E2M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-succinylbenzoyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91862">
        <property type="protein sequence ID" value="SEG91862"/>
        <property type="gene ID" value="SAMN04489712_1315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="435"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="538" mass="58887" checksum="963F23195E37A8FC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4F3</accession>
    <name>A0A1H6E4F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92181">
        <property type="protein sequence ID" value="SEG92181"/>
        <property type="gene ID" value="SAMN04489712_13249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="514" mass="55205" checksum="1A6227A014D12870" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4J2</accession>
    <name>A0A1H6E4J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reductase C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91914">
        <property type="protein sequence ID" value="SEG91914"/>
        <property type="gene ID" value="SAMN04489712_13126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="316"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="42093" checksum="2405EC3A8ED627F9" modified="2017-01-18" version="1">MRGVTIVGASLAGVSVAEGLREHGYQGPVRLVGAERHLPYDRPPLSKALLRADEPEDPPLLRPRSWYDDNEVELLLGRRATALEADRSAVVLDDGERLAWDHLVIATGSRARRLPGLDGPSVHHLRDLDDARRLRGVLAEPGRLVVLGAGFIGLEAAAAAAERGWTVTVLEREPAPLVRVLGPQAGALCVRTHLARGIDLRFGAAVAETCPAGVRLEDGSVVPADAVLVGAGAVPNTDWLSGGGVEVDDGVVCDAHGRTSRPGVWAAGDAARWRNELTGRHRRVEQWTSARDQAALAARAIATGDAGGAGWAGPPYFWSDLFEHKVQFCGHAEPDSTVWTAHDGRRSLALFGRGEQLEAVLTVDAPRLLGLGRRKLAERTGWAEAVAWAKEAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E834</accession>
    <name>A0A1H6E834_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93882">
        <property type="protein sequence ID" value="SEG93882"/>
        <property type="gene ID" value="SAMN04489712_14119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="125"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="345" mass="37009" checksum="B42B6769951DE208" modified="2017-01-18" version="1">MVAHEYACTLARSRLIELAACTDIDSRRADSFAEHHHIPTVAPLDDLLIEHAIDLLVILTPPDSHVQVARTAIEAGVHVHLEKPLALDVTEAERLLTFAAQQQVKVGAAPDTFLAPPTQTAAAAIGTGAIGEPLFASAALLSGGPERWHPAPQPFYAPRMGPLLDMGPYYLTQLTHLLGPITQVEGATATTRPHRTIATGPQAGHHFTAQAFTHVEALLKTASGIPVTFTASFDATATARPHLEINGTEGTLILPDPNFHHGPVQLRRSDSPDWHTLAPQTAVPETIGRGMGVLDTAQALRTDRPTRGTGEQALHVLHVLDLIYRTASNDERHTSITLRNGKSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8B1</accession>
    <name>A0A1H6E8B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase, N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_14210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG93962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93962">
        <property type="protein sequence ID" value="SEG93962"/>
        <property type="gene ID" value="SAMN04489712_14210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="202"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG93962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="363" mass="38232" checksum="866C20542441245D" modified="2017-01-18" version="1">MSDHLEDLAEAVRGVLSSRRPVDATAPAGLDTALWKELEQLGFTSLALPEELGGGGGTVRDAAVLVREAASACAAVPVAEAAFVAAPMLAAAGARPPNGPLTAAPGDLYAEPVHGGTWRITGSLSRVPWLRSAGHVVTPVTTPDGPAVAVVPVGHRLLRLVEGTDLAGEQRDGAVLEGVETDQVFPLPAGTWRRDAELYGAAARALQMAGAARGVLEATLRHVGERVQFGRPLVRFQAVQHQLAALAADVVTVEVSADAAILALLRTGYDRELMVASAKAEASALARSVAAVGHQLHGAIGFTMEHRLGAYTRRLWSWRDEYGNELYWHRRIAELVADRGGDVWGLVADADRRPEGAQVHVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8R4</accession>
    <name>A0A1H6E8R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_13817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93314">
        <property type="protein sequence ID" value="SEG93314"/>
        <property type="gene ID" value="SAMN04489712_13817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="70"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="173"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG93314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="43615" checksum="75BB5144BCA96DED" modified="2017-01-18" version="1">MRDGVRKVLNKRESKRLGKDVYSWKVPYRDANGKQSSETFGTLKEAKAFRDKTRSRRNEGVIIDVKAGAVSVAGYAAEWLKTAEVKRPSTYKNYDQYVRLHIVPALGGRRLRAVTRAEVQDFVNGLVGKGLSPRTVRNIYMALASMFRSAHAIDGRIPSSPCVRITLPEVPDNEVQVLTVSQVRALAASMPQRYAVAVLLSVGTGLRISEVCGLTWDRVDLETGMLKVDRQMTEKGCRLAPPKTRYSRRAVPIPETVVAALREHRESFPPVAQDVSHVDGSTVRDAELLFTRPKGGPLTSYGLREAFYLARARAGIPETVVFHALRHTYASLQIAAGTSLPALRDRMGHSSIMITADTYGHLYPEEDDRTRSAIDDAFAADGDPDDRAAVVPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9B6</accession>
    <name>A0A1H6E9B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94282">
        <property type="protein sequence ID" value="SEG94282"/>
        <property type="gene ID" value="SAMN04489712_14511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="742" mass="80441" checksum="6E4AC00B0FFF556B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAB3</accession>
    <name>A0A1H6EAB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron(II)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93856">
        <property type="protein sequence ID" value="SEG93856"/>
        <property type="gene ID" value="SAMN04489712_14110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="182" mass="19614" checksum="A3061A8C2C162D43" modified="2017-01-18" version="1">MDLVWVLVPGGVCRYGDEGRPRDIPPLRWTATVLTADQLGVPGEAELPLTRICHQEATELAAQVGGRLPRSVEWEWMAAGPARRRYPWGDQPWRPELANLRDSGIGGATPVASYAQGATADGLYDVAGNVWEWTSTPVMGGGYVIRGGSFASPPLYAQCTFLNAAPGELRSRGIGVRAVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBP1</accession>
    <name>A0A1H6EBP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_14411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000044">
        <property type="protein sequence ID" value="SEG94215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94215">
        <property type="protein sequence ID" value="SEG94215"/>
        <property type="gene ID" value="SAMN04489712_14411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="116"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG94215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="35020" checksum="6D8E2828EB51CAC8" modified="2017-01-18" version="1">MTTTSSNNVVPLAAAVTLGEAAEQFLARRDLDADTLRSYGQMLRRLRRELGDTVPLAGLTADQAAAVFTAAWDDAAPRTWNRHRSALRSFTTWAADRGQVTTDLAALIERRPEKHDRTRVIDRHTVDALLADPKVALREKALRRLAYESAARADEVLALNIEDLDLANKRGQITGKGGDIRWIHWQSGTARLLPRLIGGRTSGPLFLADRRPAPARTPAAADLCPHTGRSRLSYERAEYLFKQSTKKHDRRKRGFTLHQLRHSRLTHLAEDGWSAPMLMGLSGHTNIRSLAIYTNVTAEAVGAALAKQDPARRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECS9</accession>
    <name>A0A1H6ECS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein, DUF305 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000052">
        <property type="protein sequence ID" value="SEG94829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94829">
        <property type="protein sequence ID" value="SEG94829"/>
        <property type="gene ID" value="SAMN04489712_1527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296804" evidence="1">
        <location>
            <begin position="29"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="48"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="199" mass="21521" checksum="FFCA4BADD59A8883" modified="2017-01-18" version="1">MKRGPAKYAAAALLTVCALLLFAGCAGALRPGAEPSPDPGGPGFNGTDVMFLQMMLPHHGQGVRIVRLAEGRAVRPEVRTLAAAIEATQLTEITTMAGWLRAWRRPPRAPRHAHAAHGGLPETSESEIAALARATGPAFERAFLNTLIAHQDDAVQLARMQLADGIDPRVRDLARRMERSRSAQIKQMLLFLDNTDTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EDB9</accession>
    <name>A0A1H6EDB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperonin GroEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000056">
        <property type="protein sequence ID" value="SEG94956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94956">
        <property type="protein sequence ID" value="SEG94956"/>
        <property type="gene ID" value="SAMN04489712_1564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="29" mass="3037" checksum="DEC06FDBA2A1BE43" modified="2017-01-18" version="1" fragment="single">FLTTEAVIAEKPEKDKAPAMPGGDAGMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EDU1</accession>
    <name>A0A1H6EDU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000062">
        <property type="protein sequence ID" value="SEG95044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95044">
        <property type="protein sequence ID" value="SEG95044"/>
        <property type="gene ID" value="SAMN04489712_1621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG95044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7006" checksum="6FF26F060E80FF2A" modified="2017-01-18" version="1" fragment="single">QSGPTLPAPDKGQDDEGQDDRAASAETPTPPPVDAVVATRHDTTHEAAAARGAAHARALLAAARRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S1E5</accession>
    <name>A0A1H5S1E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44300">
        <property type="protein sequence ID" value="SEF44300"/>
        <property type="gene ID" value="SAMN04489712_10137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF44300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="263" mass="28804" checksum="395B5DDD89501CE3" modified="2017-01-18" version="1">MGGASGPEPQYLVTAPGPVRYVEVTYRGEVIGCLWASVKYDAAGYVRRLEAEPPEAFRAPLVWSRRLRAAKAEGLPALEALRRWRGAPEDPEGGTVVADAPERDADSYDALKKQLNPGHVDPMADFFAQTPTWPDGTPIDRSKGWDPLSPMKIPETDYPASTDGPVRYLPVTRGDTLLGYLWASAADDAAYYVGRTDAGADGWNAGVPWVLRLRRAQREGLTPLQALRRWKGAPEDPRAGTIAVDAHEQEASSLDDLKRLAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SFJ2</accession>
    <name>A0A1H5SFJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="9">DHOD</shortName>
            <shortName evidence="9">DHODase</shortName>
            <shortName evidence="9">DHOdehase</shortName>
            <ecNumber evidence="9">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrD</name>
        <name evidence="12" type="ORF">SAMN04489712_101162</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="9">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48527">
        <property type="protein sequence ID" value="SEF48527"/>
        <property type="gene ID" value="SAMN04489712_101162"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="11">
        <location>
            <begin position="4"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF48527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="339" mass="34958" checksum="206F8F96562C2A91" modified="2017-01-18" version="1">MTDLTTRLGTLELANPVLTAAGCGGTGRELARFFDLARLGAFTTTSVMLRPRAGRPTPRVAETPSGVLTAMGLPGPGVDSFLETDLPWLAEQQVPVIVSVAGHSLEEYAEVARRAQESPAVAAVEVNLAAPNVEDRGRMFGRLPGPAADVVRAVRAVTRRDAPVLAKLAPDVSDLVTIALACVDAGADGLSLINTMAGLAIDPHTLRPTLAGVSGGLSGPAIRPVALRCVYEVHAALPGTPIVGIGGVATGLDALEFVLAGASAVAVGTTLFHDPTAGPRIARELEEALSARRIGRLADAVGLAHRLPPQGHVGHVPPQISPPPGADERRTEESKEKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SH03</accession>
    <name>A0A1H5SH03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetracyclin repressor, C-terminal all-alpha domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_101207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49896">
        <property type="protein sequence ID" value="SEF49896"/>
        <property type="gene ID" value="SAMN04489712_101207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF49896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="23905" checksum="A253272FBF14C77D" modified="2017-01-18" version="1">MARALELADAEGIEAVTIRRLAQELGVTPMALYWHFKNKEELLIGILDAVFGQLIAAPAVGEPWQRRLRIVLAALVGVLRRHRWVPSIHQAVSKQRSESFQRATDYALGLLAEAGYPPQRAYQVASYLLNGATALVANDPTGPPGLSEQDAGQWRRTHRLELESLPPGEFPCLVEYGRTLVEEPDVEGYYAFGVDLLMAAVETMAPAGQGPAAPAPPGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SHP2</accession>
    <name>A0A1H5SHP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF50203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF50203">
        <property type="protein sequence ID" value="SEF50203"/>
        <property type="gene ID" value="SAMN04489712_101218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF50203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="32488" checksum="C9440796E469D41E" modified="2017-01-18" version="1">MRPFTAAAVQFAPAAGPLTERTVRENLDKAVAWTGRCVAATGAELVVLPESCTTGFTPGVPAGELWSLMSQIPGPVTEPLQEAARDLGVHVCFGTYERGGSPGVVHNAAVLVGPRGDVLGVYRKTHPFGGEDARRGGWVTAGTDVCVVDTALGRIGMAICFDGDFPELWRIQAVRGAEVICRPSALLRSADIWELTTRARAYDNHVYVVAANAVGADPAGVLYFGNSLIVTPIAEVVARAATQESWVAARLDPAAAMASLTPGSSVPQPFDHLAERNLELYDKHAADLLGPAQTTFPYSPYGSPPSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SPP2</accession>
    <name>A0A1H5SPP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="6" type="ORF">SAMN04489712_101308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52495">
        <property type="protein sequence ID" value="SEF52495"/>
        <property type="gene ID" value="SAMN04489712_101308"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="28"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF52495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="366" mass="39967" checksum="BDA346A1B86C50D3" modified="2017-01-18" version="1">MTSLNDLPLREDLRGRRPYGAPQLDVPVRLNTNENPYPPSPQLVKALGEAVADVAAALNRYPDRDAVALRADLAEFLNRDTPGADLTAERVWAANGSNEIIQQILQAFGGPGRRALGFEPSYSMHPIITHVSGTEWINAQRDEDFGLDPERAVAAIAEHRPDVVFLTSPNNPTGTALPLEALEAVLSAAPGMVVVDEAYGEFRREDTLSALELLPEHPRLIVTRTMSKAFAMAGARLGYLAADPAVIEALLLVRLPYHLSSVTQAVARTALTYAEELLGTVDTLRAERDLIVGWLRSQGLRVADSDANFVLFGAFPDRRRVWQAVLDQGVLIREVGPPEWLRVSVGTPEEMAAFRSALTTALKENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SRJ8</accession>
    <name>A0A1H5SRJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_101334</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53179">
        <property type="protein sequence ID" value="SEF53179"/>
        <property type="gene ID" value="SAMN04489712_101334"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="12">
        <location>
            <begin position="75"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEF53179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="23291" checksum="7C8BDC5E9E182DF6" modified="2017-01-18" version="1">MVTDRVHDEVKDASVTSSSPAGGLPRWLLPAVTFALPVLLAWTAWAKVTQQWVGIAGGLAIAALLGWAAATGRTDPWTTTAARAGLAVVLGWAGLAKATEPPALQELAVEAYRLLPDAMITPVGVGLPIVEIVLAVLLLAGFATRFTGALSGLLMVVFIAGIASAWARGLKIDCGCFGGGGEVADPPYLSEIVRDLGFLALAAWITVRPPGRLALDRKIGLYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T9A0</accession>
    <name>A0A1H5T9A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pectate lyase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58567">
        <property type="protein sequence ID" value="SEF58567"/>
        <property type="gene ID" value="SAMN04489712_101507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectate_lyase_3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="233"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF58567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="537" mass="57089" checksum="A6D8ECC1F3779127" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TP52</accession>
    <name>A0A1H5TP52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphotriesterase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="2">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64632">
        <property type="protein sequence ID" value="SEF64632"/>
        <property type="gene ID" value="SAMN04489712_101698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF64632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="34727" checksum="B689C8C72A2520B9" modified="2017-01-18" version="1">MSRVNTVLGPIPTEELGLVAVHEHIGYGMPGSELDTTWWKTPEQRYAETVPKLRRFHEYGGGTFVDATGICNGRDVDYYRSLSAKTGVHIVASTGFVGGDTALPFFARASVEYLAEHFVHEITVGIGDTGGRAGIIKVGVSRGGRMTDLDKRIYRAAARAALTTGVGILTHLAVDAENAIAIFNEEGLPLDRVLFGHVDDGVNADKTRDTWIADQGGRIGFDTFGYETELPDPPFWARPRKERLDHFLRFISGEGRIRQVLASADANCSPLGWPGVRGHTVNYLFEDLIPDLRAAGLDEAAIKTIFVDNPADFLSIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TY91</accession>
    <name>A0A1H5TY91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67766">
        <property type="protein sequence ID" value="SEF67766"/>
        <property type="gene ID" value="SAMN04489712_101792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="133"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="243"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF67766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="432" mass="48511" checksum="BEB5734AB4603B2B" modified="2017-01-18" version="1">MAWDFETDPRFQEELDWVEEFVRTEVEPVDRVIEHAWDVRDPLRNALIRPLQHTVRERRLWACHLGPELGGPGYGQLKLALLNEKLGRTHSGPVVFGCQAPDSGNAEILAHYGSDHLKKAYLEPLLDNEIVSCFSMTEPHGGSDPTGFRTTAVLDGDEWVINGEKWFSSHALFADFLIVMAVTEPEAPRHKSMSMFVVPVDTPGVERVRDVSVWGHEERVGTHQYLRYTDVRVPAENLLGERGEGFAVAQTRLGGGRIHHAMRTVGLVGQAFELMKRRAVSRTAGGQRLADRQLVQEMIADSWIQLEQFRLLVLRTAWKIDKYNDYRRVRADIAAVKAAMPKVLMDVASRAIQIHGSLGISKELPFGTWVMESFHMGLADGATEVHKVNLAKALLRETQPDEGLFPPYILPTLAGQARERYADIIAELDAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UWF1</accession>
    <name>A0A1H5UWF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79300">
        <property type="protein sequence ID" value="SEF79300"/>
        <property type="gene ID" value="SAMN04489712_10258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009597">
        <property type="entry name" value="DUF1206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06724">
        <property type="entry name" value="DUF1206"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="206"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF79300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="283" mass="29790" checksum="C803E53F30988629" modified="2017-01-18" version="1">MAVGMAGNDVRRAGRQAAGHPLFHRLSRAGLAAKGVIYLLIGLLAVQIGLGDTGEEADKSGALQTVADKPGGTVVLWLLVIGFAGLALWRYAESAYGQPGPDGRKATKRLASLARAVFYTVSCLAILAFVLGQGTSSSDDQSKEFTAKAMAEPGGRWLVLAVGLGFVGWGVGNIVNAARRKFLDKLNTGQMSSRTRKTVKVLGIVGRSARGLVFGAVGVFLAHSAITFDPDKAKGVDGTLREFADTPAGPWALVAVALGLVTYGLYTFCEARWRKIEVVRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UYK6</accession>
    <name>A0A1H5UYK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80093">
        <property type="protein sequence ID" value="SEF80093"/>
        <property type="gene ID" value="SAMN04489712_10290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF80093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="72" mass="8010" checksum="E2DC6B197E1615F5" modified="2017-01-18" version="1">MGDFEDLKAAIEEEFPGWLVWRSDAGRWYATRSGDLTDAQLQAGYAMTVAADDSSGLRELLVEQARRSLEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UZD9</accession>
    <name>A0A1H5UZD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79831">
        <property type="protein sequence ID" value="SEF79831"/>
        <property type="gene ID" value="SAMN04489712_10280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="63"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF79831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="32227" checksum="64BF62C0F1A1235C" modified="2017-01-18" version="1">MRTTETSPQQPSNGTSLPQAPGSPEAHHPVVGHPAGPRSAPAPGQRHPLELTGRRVQWPTVTAVIPTLNEADNLRWLMPRLTAVDEVVIVDGQSTDGTVEVVLAVRPDAKIIVEPPAGKGAAMRAGMAAATGDLLIMLDADGSMDPAEFDSFLALLCRGFDFVKGTRYGCGGGSDDLTGLRSVGNRVLTRLANVLYGQNWSDLCYGYVALRRAAVPRLCLESTGFEIETEMCVNAVRAGLRIAEVPSHETERRFGESNLNTFRDGWRVLRTMVRLRFGGPLERPAEPAPAEPLPALSTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V246</accession>
    <name>A0A1H5V246_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Osmoprotectant transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80798">
        <property type="protein sequence ID" value="SEF80798"/>
        <property type="gene ID" value="SAMN04489712_102113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="2">
        <location>
            <begin position="42"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF80798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="306" mass="32144" checksum="3106566A535CFB22" modified="2017-01-18" version="1">MIRIIRGAALTLAAALALSACGGGGDDDPLGGGGAGGGGSQTLVVGSADFPESELLGEIYAQALEAKDIKVERKFKIGAREVYYGQVAGGSIQVFPEYNGALLERVDQGNKASTTQEVDAALKEKLPPELEILNASQAEDKDALVVTGDTARKHSLKTIADLKDVAGDMVVGGPPEFKTRRQGMVGLQEVYGLKFKQFKSLDTAGPITVSNLSKGQVQAANLFTTDPAIAKNGFVALEDPENVFGAQNVVPLVYKSKVNETARAALNAVSAKLTTADLLAMNGQMAEQKLDPEDVAQEWLKKQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V8U5</accession>
    <name>A0A1H5V8U5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bioD</name>
        <name evidence="6" type="ORF">SAMN04489712_102198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83181">
        <property type="protein sequence ID" value="SEF83181"/>
        <property type="gene ID" value="SAMN04489712_102198"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF83181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="24181" checksum="1DEE2FA0FC35F959" modified="2017-01-18" version="1">MVTGTCTGVGKTIVTAALATVARARGASVAVVKPGQTGVGPDEPGDLDDVRRLAGVEDLHEFARFPDPLSPAAAARRAGVPPLRLADAAKRVRELADGRRLVLVEGAGGLLVRYDDDGTTVADLARWLNAAVVVVTRPDLGTLNHTALTLEAMAHRGVQLAGVVIGEWPQEPDLAMRSNITDLETISARPLAGALPAGAGGLDPAEFLLAARAGLAPALGGTFDAATFRNTYALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VEJ5</accession>
    <name>A0A1H5VEJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85466">
        <property type="protein sequence ID" value="SEF85466"/>
        <property type="gene ID" value="SAMN04489712_102281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006765">
        <property type="entry name" value="Polyketide_synth_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038474">
        <property type="entry name" value="Polyketide_synth_cyclase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04673">
        <property type="entry name" value="Cyclase_polyket"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF85466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="12298" checksum="B12A784887ACDA10" modified="2017-01-18" version="1">MHSTLIVARMAPGSAGDVARLFGEFDRTEMPALMGTRRRQLFSYHGLYFHLQDFDGDGAASIDRARSHPLFVRISEDLKPFIAPYDPQTWRSPADATADRFYHWARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VFM7</accession>
    <name>A0A1H5VFM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86073">
        <property type="protein sequence ID" value="SEF86073"/>
        <property type="gene ID" value="SAMN04489712_102304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF86073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="151" mass="15969" checksum="09B14C7EA26FE7BE" modified="2017-01-18" version="1">MTSATTRPARPGPRHAEVTAGLALPARTFTVTRADLVRYAAASGDFNPIHWNERIARAVGLPDVIGHGMLTMGLAIRAVTDWAGDPGAVVEYGTRFLRPVVVPDDDLGVEATVSGRVAAVLPEPRVRVDLDVRVGADKVLGRTRAVVALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VQZ7</accession>
    <name>A0A1H5VQZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulator of SigK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sigma-K anti-sigma factor RskA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89755">
        <property type="protein sequence ID" value="SEF89755"/>
        <property type="gene ID" value="SAMN04489712_102425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF89755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="23263" checksum="59755E5AF4B4B1BC" modified="2017-01-18" version="1">MGGMNGCRDIQPLLGMYALGRLTEREMTALQAHLDGCPLCRIEAAELRGVAEALVHADPERVEYRPEPPPWLRKSVFDRIDGARRRTRRRAAALGLAGLTAAAAAVTAFFLLGAPAAPDGPDTPTVAYSAGGVRASATLTPRPWGTALHLSVSGLTPGQNYTVWLERPDGRRTPAGSFTAQGSTRLVMDLSSGMKPHNATALGLSVSGGGPPILRAPIPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VVB5</accession>
    <name>A0A1H5VVB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DivIVA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90946">
        <property type="protein sequence ID" value="SEF90946"/>
        <property type="gene ID" value="SAMN04489712_102467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF90946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="433" mass="48315" checksum="27812E7A4602A556" modified="2017-01-18" version="1">MQSDIDAQLSNFFEDTPPREFDVVLRGYDRHQVDEHIKQLDNEVRQAREQTQALQRELSDAHRQLQEQERPTYSGLGARIEQLLRLAEEQATELVQAARSEANEIKAAAKVDAAELRATAENEAAELRALAQREGDDMRNAAEREAEEVRTSARREADELTSTTEREVAKLRATADHEVAEKRAAAEREIAKLRTTTEREVAQLRASTKRERDEILTTAKRQADEMRAQAQRILEESEAQRAQAEAEFEIQLAARREEADRQDAERHAAAQAATQKLVAEAEQRAASAEQRAAKATQQAEQTRREADSHAKQLMANARKNSDQVIAEAKSQAEQLLAETKAEAERIRTAAQRQVDELTRQRDSITSHLNQLRQLLGGGAGAPMMPPLGGTEEVSAAPEKPALSAPEPKPAAAKQPAKAATAKKQDDDEDWWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W139</accession>
    <name>A0A1H5W139_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93239">
        <property type="protein sequence ID" value="SEF93239"/>
        <property type="gene ID" value="SAMN04489712_102552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041642">
        <property type="entry name" value="KstR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17925">
        <property type="entry name" value="TetR_C_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF93239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="207" mass="22001" checksum="DE236B6C63CE9B56" modified="2017-01-18" version="1">MPGDVRITVTRSLSKDQQARRARLIDAARELALQGGYAAVTMHDVADRAGVARATVYRYFATKDHLLTEVAVTWAHVVTDGTAALAVGDTPAERLTGLLVRIVEVAAADRTLTSAVIQAVTSDDPSVEDARTALFLLVRDRLAAVIGEPVPDLADIEIVLGHVLLAALVSLTSLGRPLEEVRQMVTTAGRLIMAGVPARRDGPAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W6Z8</accession>
    <name>A0A1H5W6Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxyl-terminal processing protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94951">
        <property type="protein sequence ID" value="SEF94951"/>
        <property type="gene ID" value="SAMN04489712_102603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009287976" evidence="4">
        <location>
            <begin position="42"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="106"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF94951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="42052" checksum="4E72CBCAD7547911" modified="2017-01-18" version="1">MLRLTGRVPRGLTAGGLTRGAALVLVVVCAYGAGVATGAGAPPSAEPSRPGPLDEAAGRIARESALPVGRADLQRAAVDGMLRRLGDRWARYYTAQEYDDERGRLNGRYSGVGLWLGVEEDPAGGPGPVRVASVQPGSAAERAGVRVGDVVARVGDRPVDGWTVGRVAAALRGGPGSAVTLTVRRGSAEHRFRLVRATVRTGDVTVQQRPGDVQLIRVSAFTRGVGRQVRDAVGRQADRHRGGLILDLRGNPGGLLDEAVETSSALLTDGTVVTYERRGAPPRELQVTAPGDGRTPLVVLVDAGTASAAEVVAGSLRDRDRAVIIGSRTYGKGSVQEPVRLRDGSVIELTVGRYRTPSGRDLDGAGIDPDVTVSADHPPEEAVRRADTVLRGLVAAAPTKDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WA46</accession>
    <name>A0A1H5WA46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS system N-acetylglucosamine-specific IIA component, Glc family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95687">
        <property type="protein sequence ID" value="SEF95687"/>
        <property type="gene ID" value="SAMN04489712_102627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
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        <property type="entry name" value="SSF51261"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF95687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="149" mass="15358" checksum="A053451BC51C6C27" modified="2017-01-18" version="1">MTRVLAPVSGQVVGLAGVPDPVFAQAMVGPGTAVDPERGRGEAIAPVSGKVVKMHPHAYVVVDGEGHGVLVHLGIDTVQLKGRGFELLATEGEEVVAGQPLVRWNPAEIEAGGRSPVTAVVALDAAAEALSEVRESGRVEKGTGLFSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X361</accession>
    <name>A0A1H5X361_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">AAA domain (Dynein-related subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05825">
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        <property type="gene ID" value="SAMN04489712_10358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="96"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG05825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="377" mass="40604" checksum="A582EB62D090C728" modified="2017-01-18" version="1">MAEAGGLRSSDRAGAAPSEDTVLRPHAEQQFADELALLAEHDDRPRPSGWRLSPWAVTTYLLGGTLPDGGVITPKYVGPRRLMEVAVATLATDRALLLLGVPGTAKTWVSEHLAAAVCGDSTLLVQGTAGTAEEAVRYGWNYARLLAEGPSEQALVPSPLMRAMREGMVARVEELTRMPSDVQDTLITILSEKTLPVPELGAEVQARRGFTVIATANDRDRGVNELSSALRRRFNTVVLPLPASTDEEVDIVARRVEQLGRSLELPQAPAGLEEIRRVVTVFRELRSGLTADGRTKLKSPSGTLSTAEAISVVTNGLALAAHFGDGVLRAADVAGGIVGAVVQDPASDRVVWQEYLETVVRERGEWRDFYRACREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X5D0</accession>
    <name>A0A1H5X5D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06476">
        <property type="protein sequence ID" value="SEG06476"/>
        <property type="gene ID" value="SAMN04489712_10378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="840"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG06476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="909" mass="97353" checksum="865DDF3023B33F4E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X840</accession>
    <name>A0A1H5X840_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_103133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07902">
        <property type="protein sequence ID" value="SEG07902"/>
        <property type="gene ID" value="SAMN04489712_103133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="6">
        <location>
            <begin position="26"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="7">
        <location>
            <begin position="405"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG07902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="524" mass="54438" checksum="4C6510E5B1D80646" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XAE6</accession>
    <name>A0A1H5XAE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08405">
        <property type="protein sequence ID" value="SEG08405"/>
        <property type="gene ID" value="SAMN04489712_103153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG08405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="22267" checksum="C67D820694E7B87C" modified="2017-01-18" version="1">MADITVLIVDDHPVVRDGLRGMFAATTGFQVLGEAADGRQAVALAEELRPDVVLMDLRMPGGGGVEAITELTRRGLPCKVLVLTTYDTDTDTIPAIEAGATGYLLKDAPRDDLFNAVRAAAEGRTVLSPAIASRLVSRVRQPRGESLSTRELEVLRLVARGTSNREIAAELFISEATVKTHLTHIYAKLNVKDRAAAVAAAYGKHLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XAR8</accession>
    <name>A0A1H5XAR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08550">
        <property type="protein sequence ID" value="SEG08550"/>
        <property type="gene ID" value="SAMN04489712_103159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="PTHR37539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="123"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG08550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="417" mass="46189" checksum="5341646E49831657" modified="2017-01-18" version="1">MSREQRLAHPAWMTRGPWKATLRLAPGDIRATPSQLAAFRSFAQAGDPPADAVVEMMARLPGGAGRRLFEQAVEKGIDALGDPPRELVEFFAAVDAVPYWVDPDLLDRGARVVGRTGLLGLTMVMPCASLYGGYLASRANKTLMRTGYLDTMAPRRLAETAGWWVDVTTPGGLGRFEAGFQGTLRVRLMHAQVRAAMRRRDDWDHDTWDAPVNQVQLAGTLLLFSHVMLLGSRALGFQFSAADQAAVRHLWRYVGHLMGVDPGLLPATAADAWRLYWLEAATEFLPDEDSRRLGRALMDAAAPLLLTSRWQDSVPARHALTNYLFAYSRLILGRRNADFLGAPDNRLYRAAVLGTAATVFAAESARRVIPGVTGLCERLGQRQRTTMVRRLIREQHGDRSHSRYDTPGRPRNTAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XI85</accession>
    <name>A0A1H5XI85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11468">
        <property type="protein sequence ID" value="SEG11468"/>
        <property type="gene ID" value="SAMN04489712_103268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG11468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="36702" checksum="0FF3FD2707F08AAA" modified="2017-01-18" version="1">MAVFGIDYAWGRPGPAALKRAGAKFVCRYVSHDTTGKDLTRAEADQLSEAGLWLVVVWETTASRALSGRAGGAADARDADRKAQACGMPADRPIYFAVDFDASAAQQEVINAYLDGAAGVIGRDRVGLYGGYGPVKRALDAGKARWAWQTYAWSGGRWDDRAHIQQYSNERELNGVSVDYNRAVTGDYGQWRVGVSPAEDDMPEYVSVGADAGQSLPSGQWTTIVWDREYSDSTRQHRDAGGPGLLNGPARYALTASATLRGVPAGTEVRARAIEVDSADADEVATGPVQQYAANGQGDLAVLYGLPADTVDEGRWLGFQVRHDAPGPITVADAKAKVLYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XN11</accession>
    <name>A0A1H5XN11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13092">
        <property type="protein sequence ID" value="SEG13092"/>
        <property type="gene ID" value="SAMN04489712_103326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="5">
        <location>
            <begin position="647"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="6">
        <location>
            <begin position="1185"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1600"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1729"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1602"/>
            <end position="1628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG13092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="2227" mass="230769" checksum="578042ECF082FF96" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XQJ3</accession>
    <name>A0A1H5XQJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secondary thiamine-phosphate synthase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13988">
        <property type="protein sequence ID" value="SEG13988"/>
        <property type="gene ID" value="SAMN04489712_103362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG13988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="14676" checksum="5E77E03429D5BE39" modified="2017-01-18" version="1">MRSKVIRVTTGGRETVHDITSECASFAAEAGRQAGGDGLLHVFVPHATAGVALIELGSGSDEDLLAALADLLPADDRWRHRHGSRGHGRSHVLPALVPPYATIPVIGGRMALGTWQSVAVVDLNVDNPDRQVRLSFLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XT01</accession>
    <name>A0A1H5XT01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG14567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG14567">
        <property type="protein sequence ID" value="SEG14567"/>
        <property type="gene ID" value="SAMN04489712_103385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG14567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="74" mass="8356" checksum="E127CA227FB2E740" modified="2017-01-18" version="1">MQPSPEAVEWGRRQAARSPRWSDAKWQQVATIFGVVLAPRQDAHQDDQAEQDQADQQHDEHQADEHQAAGRDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YKQ0</accession>
    <name>A0A1H5YKQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24713">
        <property type="protein sequence ID" value="SEG24713"/>
        <property type="gene ID" value="SAMN04489712_10469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG24713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="75" mass="8229" checksum="769993DA6F0D49A9" modified="2017-01-18" version="1">MTSSRAARRRHLPTSPFNPPQAAPAPETYALHDQVTHEKYGLGRVVGVEEGVAVIVDFGLPTLRIVAPYHKLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZL1</accession>
    <name>A0A1H5YZL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28857">
        <property type="protein sequence ID" value="SEG28857"/>
        <property type="gene ID" value="SAMN04489712_104241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="118"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG28857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="300" mass="32843" checksum="6192AE28005CB995" modified="2017-01-18" version="1">MEPGRPGAASNPAGLMPHEIRSARAASDDAARRTGAVQRKAYAVCRGFRPPGIADPRGILRIRLPSATVAEIAAGAVPSPNIWNSPQVYEIENRAVDPDGVLESALRRIRPWAGATVLDLGCGTGFHLPMFAREASRVVGVEPHAGLAAAARRRVRDLTNVTVRVGAAQAIPLPDASVDVVHARWAYFFGPGCEPGLAELRRVVRRGGAAMIIDNDATRSTFGGWFRRWLPSYDSGAVERFWARQGFAREPLTFRWSFGSRQDLAAVLRIEFPAELAEAFLAEHPGLEVDYAVNLWWRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z4Q3</accession>
    <name>A0A1H5Z4Q3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_104317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30635">
        <property type="protein sequence ID" value="SEG30635"/>
        <property type="gene ID" value="SAMN04489712_104317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG30635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="30626" checksum="CC990E3AF700AF2F" modified="2017-01-18" version="1">MGTRTRLNGDGPATAARRETVPTVRRTLPLRVEAVRQLRRRRTLVAFAILLVLPWVLVAAFQIGGDPGREAPGLVTVATASAMNFALFALFVSAGFLLVVAVALFCGDTVAAEAGWSSLRYLLAAPVPRARLLRQKLVVALGYAALAVFSLPAMSLLAGTVAFGWGAVELPTGGTVPAGTALGRMAVIVGYALVSQLVVAALAFLLSVTTDSPLGAVGGAVGLVIVSNILDAVTALGGVRDFLPTHWSYSWMDALQPQIQWTGMAKGTAISVAYSVVLLALAFRRFRGKDVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZBF5</accession>
    <name>A0A1H5ZBF5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="8" type="ORF">SAMN04489712_104422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32696">
        <property type="protein sequence ID" value="SEG32696"/>
        <property type="gene ID" value="SAMN04489712_104422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG32696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="13181" checksum="71AD40F7913D303C" modified="2017-01-18" version="1">MTGRVTSARAKSRARRHLRVRKKVVGTAERPRLVVTRSTKHMFAQVIDDTVGHTLASASTMEADLRAADGDKTAKSRQVGELLAARAREAGVAKVVFDRGGNRYHGRIAALADGAREGGLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZIT0</accession>
    <name>A0A1H5ZIT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_104550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35557">
        <property type="protein sequence ID" value="SEG35557"/>
        <property type="gene ID" value="SAMN04489712_104550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="12">
        <location>
            <begin position="128"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG35557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="224" mass="23338" checksum="90D2B9DC0749F7B3" modified="2017-01-18" version="1">MPASTQAHVATAGKGSPHPERDAERARLRRELHDGLGPILTAVAMRAATAGRLLDGGSAEAAGAMLDLIQSDVQGAVAELRALLDGLRPPCLEAHGLAAALYELAAPGDPGPVVEVRVGEPLGNLPPAIETAAYRIACEAVHNARRHAEATRVRVTLVREGDWRLVLTVADDGHGRVPGGSAGLGLATMRQRAEEVGGELTLDAVPGHGVTVRADLPLYPRMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZUB4</accession>
    <name>A0A1H5ZUB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-phosphate glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_10516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40123">
        <property type="protein sequence ID" value="SEG40123"/>
        <property type="gene ID" value="SAMN04489712_10516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG40123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="198" mass="19468" checksum="51D8CABC6AB24706" modified="2017-01-18" version="1">MGSVLAAVIGGYLLGSVPVAVLVCRRHGLDPREAGDRNPGFWNVRELLGGRAAVPVFLGDLLKGTAAGLLGLAVSGAETGALGVVAGASVVPVYAAVAAAMAGHAWPVFAGGRGGRSILTFAGGFAVICPPAFGLGLGLVVVTGLLGRSFSLGARVGVFSLPVLQLAFAPAAQAAATGALMGLIGLRFGQAALAGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZXI1</accession>
    <name>A0A1H5ZXI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41159">
        <property type="protein sequence ID" value="SEG41159"/>
        <property type="gene ID" value="SAMN04489712_10567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG41159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="43927" checksum="AE7A1371DCA0EFC0" modified="2017-01-18" version="1">MNWRIRTHAREEQAREEQARTHDEQDRMRNEQAQALDEREPGLPDREGTRDERARPGNGQTPARHAGDERRAADGAAPAAGQEEDSPTSLSKKSWVQAVKRTFREFKTDNLTDWAAALTYYGVLSIFPAMLVIVSLVGLGGTSLSQSIVQNVGDLAPGAVRDVLANALAELQRGRGGAGLFAIIGLLAAVWSASGYVAAFMRASNAIYDIPEGRPIWKTMPLRIGVTLAALVLLSASAIAVVLSGPLAQKVGNLLGMGAAAVTAWNIAKWPVMLVAISFLFSLLYWASPNVKQGFRWVTPGGILALVVWLLASAGFAFYVANFGSYNKTYGSLAALIIFLVWLWISNIALLLGVELNAELQRGHAIAEGHPQDEEPYVEPRDTRKFPDDLRTEDRDRPSRDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZXU9</accession>
    <name>A0A1H5ZXU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40804">
        <property type="protein sequence ID" value="SEG40804"/>
        <property type="gene ID" value="SAMN04489712_10551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG40804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1089" mass="117495" checksum="173EF08EAB666EB0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A139</accession>
    <name>A0A1H6A139_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41667">
        <property type="protein sequence ID" value="SEG41667"/>
        <property type="gene ID" value="SAMN04489712_10592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG41667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="196" mass="21593" checksum="664C0D7041446263" modified="2017-01-18" version="1">MDVRRTGDGELVVHHDRIIGGLPLGRCTYQRILAAGTGRVPLLRDALAAIAGRAMGHLDLKEPGCEHEAVELALQRLGPGRFVVTTRYTQSIRLIKRDFPEVRTALSLGRALWERGAVRDLSPLSLVRGCGADMVALNHRLARIGVLRQCARAGFPAMVWTVNAEPLMRRFLTDHRVAVLITDRPERALALRSGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A1N1</accession>
    <name>A0A1H6A1N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42351">
        <property type="protein sequence ID" value="SEG42351"/>
        <property type="gene ID" value="SAMN04489712_105133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG42351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="32295" checksum="05BE4DB8AE9B2DA1" modified="2017-01-18" version="1">MAICRYGLGVRGWEWRRRRPVVVLLVIVVALGAGGYVVWSYVRPYLHGSNCEVAAVERTVPLDLEQAANAATIAGVAFRKSLPERAVVIAYATAIQESHIRNLPGGDRDSVGIFQQRPSQGWGRVDQLRDPVYATSKFFDSLVKVKDYLDRDLHDAAQQVQRSADGRAYAPHEDRAKQLAEAYTGRRPAAVRCWFSPSKRTEPRREEAVRALHQTFGTSRLPVTRDGDRHTVKVPTRRTGWAVASWAVSHAQGYGLSEVRYAGYRWKSEAGHDGWTEDGHAPADHVAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AGA0</accession>
    <name>A0A1H6AGA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ORF">SAMN04489712_105400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47097">
        <property type="protein sequence ID" value="SEG47097"/>
        <property type="gene ID" value="SAMN04489712_105400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="233"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG47097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="325" mass="35374" checksum="5241C5C384C007FA" modified="2017-01-18" version="1">MSGIKASGEKKLMLFSGRAHPDLAKEVADNLRVELTPTAAYDFANGETFVRFLESVRGSDAFVIQSHTAPINQWIMEQLIMVDALKRASANRITVVAPFFGYARQDKKHRGREPISARLMADLFKTAGADRLITVDLHTAQIQGFFDGPVDHLFALELLADHVESKLDTSQVTVVAPDAGRVRVAERWTDRLGCPLAIIHKRRDPEVANEVKVFEVVGEVEGRTCVIVDDMIDTGGTIVKAADALFEQGAARVVATATHGVLSGPAVDRLKNSRISEVILTNTLPIPEDKQFDKLTVLSIAPLIAQAIHEVFSDGSVTSLFGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AL03</accession>
    <name>A0A1H6AL03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_105530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49409">
        <property type="protein sequence ID" value="SEG49409"/>
        <property type="gene ID" value="SAMN04489712_105530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="135"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="239"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG49409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="399" mass="43285" checksum="030ECD643B9907E6" modified="2017-01-18" version="1">MSLHDTGQEVAGETETGLDDLAQEVRKWCAVRDATGWAARMAAADPQARADLQREWFLRLAEQGYAYPHWPAAWGGGRSRAEQLVIARELIRGGAPRLDLHFVALYHAAATLIVAGTPEQRETHLPAIRTGRRWCQGFSEPEAGSDLASLRCRAVPAEGGYRVTGHKTWSTGAAHADMCLLLARTGGPGRAGISYFLLDLASPGVEVRPIRNASGQEEFCEIFCNDVFVPEESRVGAENEGWRIANATLSEERGLTMLERSEEMATGMQHLVRLVAGLAPGSREEGLRILGRYSERVEAFRLLVARVLDASVEGADVAAASILKLVYSELLQDISDAGLSLAGLDGHVDGTSWTGTWQSGHWFADYLGSWEWTIGGGANDVLRNVVGERVLGLPRGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ANM2</accession>
    <name>A0A1H6ANM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, luciferase family (Includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49667">
        <property type="protein sequence ID" value="SEG49667"/>
        <property type="gene ID" value="SAMN04489712_105543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG49667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="321" mass="33737" checksum="44BA148197552CF6" modified="2017-01-18" version="1">MSDMGSGPPGGDTPTCEIGLAIQADLLTADGTDLAAFGRAVLDAGLGYVSIGDHVSHRGGQGLDGIVAATALLAAQPRLRVVVGAYQLALRHPFVVARQLATLTALAPRRLILAVGAGGDDRREVLNCGVDPRTRGDRLNESIALLHRLLAGENVDHHGTHFDLEQAFISDGGPPPDLVVAGRGEAASKRAARFGTGWLGLLVTPGRYHEMRTSVVAEAEALGRPTPTWFGLNVWCAPAENERESRERLAESLTRSFGSAADRALRYCGVGDTTKIASWLAGYVHAGAAHLSLTVPARHAEEAVERAHSLATALAEHVQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYS3</accession>
    <name>A0A1H6AYS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53514">
        <property type="protein sequence ID" value="SEG53514"/>
        <property type="gene ID" value="SAMN04489712_10697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293236" evidence="2">
        <location>
            <begin position="30"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="159"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="283"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG53514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1149" mass="122552" checksum="50C7E65FF0A3E342" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B291</accession>
    <name>A0A1H6B291_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_106195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54993">
        <property type="protein sequence ID" value="SEG54993"/>
        <property type="gene ID" value="SAMN04489712_106195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG54993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="30005" checksum="3B8C4E5568B386E8" modified="2017-01-18" version="1">MTDNLDQNAGNTPVVDQTVPQTARIWNYWLGGKDNYEVDRKVGDDILQIIPDMAVMARATRQFLIRAVRYLSGEAGVRQFLDIGTGLPTVDNTHEVAQAVAPEARIVYVDNDPLVLAHARALLTSSPEGATTYIDADLHDPGRILDEARKTLDFDRPIALMLMGILGHITDFAQAQSIVRQLLDALPSGSYLALYDATNVIRSPETNEAIRIWNESAKPPYVLRSPDDLARFFDGLDLVEPGIVSCPRWRPAPGLPGEPDEMDEFCGVGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B7I4</accession>
    <name>A0A1H6B7I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator / MocR family aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56809">
        <property type="protein sequence ID" value="SEG56809"/>
        <property type="gene ID" value="SAMN04489712_106338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG56809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="522" mass="54872" checksum="FD2541FC1102D1F9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BF65</accession>
    <name>A0A1H6BF65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PS-10 peptidase S37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="9actn-a0a1h6bf65">
        <property type="family name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59005">
        <property type="protein sequence ID" value="SEG59005"/>
        <property type="gene ID" value="SAMN04489712_10739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008761">
        <property type="entry name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05576">
        <property type="entry name" value="Peptidase_S37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293785" evidence="1">
        <location>
            <begin position="29"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="470" mass="52950" checksum="CD0FC9CE48BBCD65" modified="2017-01-18" version="1">MRGWGQRVLAAVTVAGMLGVGTAIPSHAAPAGDIVERLNAIPGMKVLWERPSGAADYRFFLLSYRQPADHRKPGTGTFEQRFTLLHKDTGRPMVLHTTGYNLRETASRSEPTQLLEGNQISVEQRFFTPSRPQPADWSDLTIWQAATDHHRLVKALKPVYSAKWVSTGASKGGMTSIYHRRFYPADVDATVSYVAPNDVVNSEDKAYDRFFEKVGSDPSCRNALKDVQHEVLERRAEFVPRYEAYAKENGFTFGNLGNADRALEATVLDVEWAFWQYSLEADCAQVPSANASTDTLWDFVDSVAGFSFYTDQGLAPYLPYYFQAGTQLGWPEPKFRYLKDVRNYPEIYRPRAFMPADLRAQMRFNPVVMADIDRWVRSHGNRLMFLYGGNDPWGAEPFRLGRGTRDSLWYEVPGLNHSAQLIRALPAGQREQAIAALRRWAGVGDTASVRLKGVSPLDGYDELQVRRPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNJ7</accession>
    <name>A0A1H6BNJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3alpha(Or 20beta)-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62212">
        <property type="protein sequence ID" value="SEG62212"/>
        <property type="gene ID" value="SAMN04489712_107281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG62212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="26437" checksum="435A3035A759E24E" modified="2017-01-18" version="1">MGQLDGKVAIITGGARGMGRSHVRRFVAEGASVVFGDILEQEGAELAGELGEAVRFVRMDVTSPEDWKNAVETAVAAYGKLDVLVNNAGIIQHKRIEDMSLQECRRILEINLIGQWLGIKAVIEAMKEAGGGSIVNVSSTEGFIGAAGLAAYSASKFGVRGLTKAAARELGEHNIRVNSIHPGGILTPMVMDPDVVAATADSADSFMKALPLGRMGRTREVSGLVAFLASDDAAYCTGSEVLVDGGMLTGAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BW55</accession>
    <name>A0A1H6BW55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase family M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64910">
        <property type="protein sequence ID" value="SEG64910"/>
        <property type="gene ID" value="SAMN04489712_10863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="144"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG64910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="285" mass="30570" checksum="D2C19635545DCC87" modified="2017-01-18" version="1">MSDRFARHLARVRTPLLLAGLAVAFSARFHGFGWVGTVMIVVGLVLIVLPAGAVRRRPPVEVDAPVRGRWVAVNSPADKVPSHGTHEFGQAYAIDLVHQPDPAADRGTVRRWPPARRPETFPSFGRPILSPADAVVVRAVDGQRDHWSRDSWPGLVYLFVVEGIVRGVGAAVSPRFLLGNHLILDLGDGVYAALAHLRRGSLRVRPGQRVRAGEQVAECGNSGNSSEPHLHFQLMDGPRPMVAAGLPFAFAFQADGTEHYGVPKGAQPFTTGPLAPDPAAAGTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BWZ5</accession>
    <name>A0A1H6BWZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RsbT co-antagonist protein RsbR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64975">
        <property type="protein sequence ID" value="SEG64975"/>
        <property type="gene ID" value="SAMN04489712_10868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025751">
        <property type="entry name" value="RsbRD_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14361">
        <property type="entry name" value="RsbRD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="155"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="280" mass="30470" checksum="9ECCA532AF76153D" modified="2017-01-18" version="1">MTNPQSGGQAHIVQLLSTRQDAALDRWTELAGATLRGRTTQTELRGELRELLSLTLASLEREDDTARSELRAVLADMSGRRARQNFTPKETAVAVFTLKQVVHELIEDADEDQAINEFVAFSRYVDDLGLLTFETYAATREQVIADQAEQLLELSTPVVKLWEGIVAVPLVGTLDSARTQVVMEALLQTLVDTGSESAVIDITGVPAVDTEVAQHLMKTIMAARLMGAECVISGIRPQIAQTIVALGIEFGDIVSKATLADALEYLLSRNGVRIVREVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXI5</accession>
    <name>A0A1H6BXI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein, AIM24 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65398">
        <property type="protein sequence ID" value="SEG65398"/>
        <property type="gene ID" value="SAMN04489712_108102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG65398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="21560" checksum="CE1E96692D779D53" modified="2017-01-18" version="1">MLAVDLMGETIRALNGSMVAYDGQMNFKRQGMTGGEGLRGALRRRVAGESMTLMEITGQGTVYLASEATEVTLIPLQGDTLFVESESLLAFDGQLRTGVQFTGLRGMGTGQGLATTKVEGHGMVAILSDGPAIGLEVTPGVPLCVDPHAYVAHRGQLQQDFVTDVNWRTVLGQGSGESVQFRYQGHGLVYVQPAERGGGIMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BZ92</accession>
    <name>A0A1H6BZ92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">moaA</name>
        <name evidence="14" type="ORF">SAMN04489712_108152</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65953">
        <property type="protein sequence ID" value="SEG65953"/>
        <property type="gene ID" value="SAMN04489712_108152"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEG65953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="329" mass="35860" checksum="C22531682443BB87" modified="2017-01-18" version="1">MLVDGFGRIATDLRVSLTDRCNLRCAYCMPPEGLDWLPKPELLTDDEVIRLVSLGVERLGITEVRYTGGEPLLRRGLPQIVRRTAALTPRPQISLTTNGIGLDRLAPALAEAGLDRVNVSLDTLDPEVFRRLAHRDRLADVLAGLAAAERAGLSPVKVNAVLMRGVNEHEAIPLLRYCLEHGYQLRFIEQMPLDAQHGWRRENMVTADEIMALLSGTFELTPDDPRARGSAPAETFLVDGGPARVGVIGSVTRPFCGACDRVRLTADGQVRNCLFATEESNLRDAMRAGATDDELAERWSAAVRAKRAGHGIDDPGFLQPARPMSAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7J0</accession>
    <name>A0A1H6C7J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68934">
        <property type="protein sequence ID" value="SEG68934"/>
        <property type="gene ID" value="SAMN04489712_10933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="302"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="546"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG68934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="730" mass="79399" checksum="0A8324F3AE859A58" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CBI9</accession>
    <name>A0A1H6CBI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cobalt transport protein CbiM</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Energy-coupling factor transporter probable substrate-capture protein CbiM</fullName>
            <shortName evidence="11">ECF transporter S component CbiM</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cbiM</name>
        <name evidence="12" type="ORF">SAMN04489712_109155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CbiM family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70258">
        <property type="protein sequence ID" value="SEG70258"/>
        <property type="gene ID" value="SAMN04489712_109155"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01462">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018024">
        <property type="entry name" value="CbiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43627">
        <property type="entry name" value="PTHR43627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00123">
        <property type="entry name" value="cbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 11" id="KW-0171">Cobalt transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG70258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="239" mass="24798" checksum="0299B87FCD430680" modified="2017-01-18" version="1">MTTVHEVLERSGVTPVHIAEGYLPVTHAVAWSAAAAPFIVHGVIRLNRQIQAAPEDKLLLGASGAFCFVLSALKIPSVTGSCSHPTGTGLGAILFRPPIMTVLGTITLLFQALLLAHGGLTTLGANAFSMAVAGPWAGYAAYLLTRRLGLLPAVFAGAFVADLTTYCVTSVQLALAFPDAESGFTGALAKFGGIFAVTQIPLAVSEGLLTVLVVRLLRTSAAADLIRLGVLRKREEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJ66</accession>
    <name>A0A1H6CJ66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG72990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG72990">
        <property type="protein sequence ID" value="SEG72990"/>
        <property type="gene ID" value="SAMN04489712_11058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG72990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="235" mass="24657" checksum="557EB82BAEA7251E" modified="2017-01-18" version="1">MSGPDTPLVELDQAGKEYPGGVTALRDVSLTIGEGELVAVVGPSGSGKSTLLNLVGTLDRPSYGTVRIAGLDVGRLTDRELSALRARLIGFVFQQFHLADGVSALDNVADGLLYTGVPPRERRLRAAAALDRVGLGHRLDHRPHQLSGGERQRVAVARAVVGEPRLLLADEPTGNLDTASGAEVLRLLHGLHASGTTVVIITHDPEVAEAAPRRIRVRDGSVTTDDTAATVGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJD7</accession>
    <name>A0A1H6CJD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73040">
        <property type="protein sequence ID" value="SEG73040"/>
        <property type="gene ID" value="SAMN04489712_11064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="500" mass="52508" checksum="C2F89D4EE55F9D1B" modified="2017-01-18" version="1">MTVLDRPVQAPESAGAVRAVLALARVEARRLLLHPMVAIALAGYLLWPLWSGSWRDTHQVLQEVDRESQLGPLLVGLAGLLAANSAVLRSLRHGTEAHFGVLVMPPWRRTVAHALSVLPLTLVVAAAVAGMFAWEATRPGAVGHASGFELATGPLMVLFFGVLGVLLGRLVPSMFAGATAVVAILAVTFVFAVLPDGVRWLVPLVADEGAAPLPSDLVGRPARWHALYLVGLTVLAGAVAALASGGRTAAVRATALGALGVTVAGTVMQVTGPSAALVEARERATRDPASVQECLRRGTTTYCAFPEFVPWVDEWRVVVDGVRSLAGEPAASRGLVVRQRVNALDGPSGGGPSGIVEELPPGPRGEVTVSTVWGDEGRLGLAVSVARGMVVDDENHGVYCDARGVLMMWMAVNGAPGGRAAFARTQTSTLWSPLLEIRLRDRENAVVRALLERPAAEVARQVKASWAELVRPDASTDRVAALLGVTAPAETAADREWRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLB9</accession>
    <name>A0A1H6CLB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase AhpD family core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73455">
        <property type="protein sequence ID" value="SEG73455"/>
        <property type="gene ID" value="SAMN04489712_110112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="20647" checksum="5EF797F553ECCC2F" modified="2017-01-18" version="1">MTARVRPGGLREVGSFTWVFARVSGRIAGTGPPNLFLTLGRRRGLFHAWLWFAGRLMPGGGLPRRESELVILRVAHLRDCRYEWEHHVRLARRAGLGTKEIDRIAQGPDAEGWTPREHALLTAVDRLHRYRDLDDAAWARLRGHLSEPECIELCMLASHYEMLATVITTLRIQPDQARSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLK5</accession>
    <name>A0A1H6CLK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_110165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73874">
        <property type="protein sequence ID" value="SEG73874"/>
        <property type="gene ID" value="SAMN04489712_110165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG73874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="78" mass="8362" checksum="ADD5FD1BD21EA924" modified="2017-01-18" version="1">MAAVRIIDDLGVVVHEITADRLELAADLAARSMLRMYDALFVQLAIERKLPLLTADAKLCSAVDGTVGTELLRGVGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CN32</accession>
    <name>A0A1H6CN32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73886">
        <property type="protein sequence ID" value="SEG73886"/>
        <property type="gene ID" value="SAMN04489712_110166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="185" mass="20616" checksum="C2AB873D3D45640E" modified="2017-01-18" version="1">MSRPWLRDERTELAAERILDAAERVFTERGVGATEMSHIAQAAGCSRATLYRYFDSRHALQVAYMHRQTHRVVQDIARHLQHLTDPRERLIEAILAALAAVRDDPALAAWFTSADSTHSAELATASPILETLCAAFLGDPSDPDTRLRARWLLRIIVSLLSTPGHDPTDERTMIELFAAPVLSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CNB9</accession>
    <name>A0A1H6CNB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_110196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74173">
        <property type="protein sequence ID" value="SEG74173"/>
        <property type="gene ID" value="SAMN04489712_110196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG74173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="230" mass="25503" checksum="4250EDB0A0A877D3" modified="2017-01-18" version="1">MLTVDKLSAWYGEAQVLREVSLDVAEGEIVTLVGRNGAGKTTLLRCVMGLHGRTSGTMSLLGDDLTALPPHRRARRGIGYVPDDRGIYATLSVEENLLLPPVSGPAPWSLEEIYQTFPRLRERRRFPGTRLSGGEQQMLALARVLRMGSRLLLCDEPTEGLSPLIVQQIGEILRQVKGRGVTVLLVEQNVHFATTVADRHYLLAEGRVVESLDNEQVRAREHELLEHLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CPK4</accession>
    <name>A0A1H6CPK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74356">
        <property type="protein sequence ID" value="SEG74356"/>
        <property type="gene ID" value="SAMN04489712_110217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="63" mass="6765" checksum="7E703940F0E32AFA" modified="2017-01-18" version="1">MTEQWRKSSHSGGANDSACVELAGLPAGVGIRDSKDPEGGRLTVRRAAFGELVRRIREGALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CU35</accession>
    <name>A0A1H6CU35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">His Kinase A (Phospho-acceptor) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_111183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76589">
        <property type="protein sequence ID" value="SEG76589"/>
        <property type="gene ID" value="SAMN04489712_111183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="156"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG76589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="372" mass="39377" checksum="DB37CD111FEE72AB" modified="2017-01-18" version="1">MIPFADLLWVAWYAAVAAAVVAVVGLVLLHALRGRSMAVQLAVVGVATVLATVSGIVVITLMMYLDAHDRSVALAVVIAAGTVAMGVSVLLGRRLVAANRMLVDAVRADPYRPPEGRLPAELAELARELDAAYGRLAAAHEREQALEASRRELVAWVSHDLRTPLAGMRAMAEALEDEVVSDPETVRAYHGRIRQEIDRLTGMVDDLFELSRIHAGALRLYRRRVGLDDLVAEAVEGTEPLARAKGVQLNGRAREGLPLEVDAAELGRALRNLVVNAIRHTPSDGTVEVVGGVEDGMACVTVSDACGGIPEDDLPRVFDVAFRGETARTPGGGGAGLGLAIARGIVEAHAGKIGVTNAETGCRFMIRLPLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZI8</accession>
    <name>A0A1H6CZI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78184">
        <property type="protein sequence ID" value="SEG78184"/>
        <property type="gene ID" value="SAMN04489712_11242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="16642" checksum="A643C45BD223A914" modified="2017-01-18" version="1">MSGIDGFYWWGESPGARFPTARLKDDRYRNLAGLLTSDIQTHGAGVLDALLLVEQARGGRTDIEEWVGNSTSAYFRPDGVSITDLGPEPQTQRYSLGEVHEALIKYWEFLCPSGGERRSALEEWARSYRQEHPQTTDPQHPCLAHLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZY3</accession>
    <name>A0A1H6CZY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78711">
        <property type="protein sequence ID" value="SEG78711"/>
        <property type="gene ID" value="SAMN04489712_112115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="486" mass="52464" checksum="0A98DF8DDC1FFE68" modified="2017-01-18" version="1">MTHIAFRSASELAKALRNKEISSRELLEEYLSRVARFNPGLNTVVTLAEEEARRRALAADEALARGELWGPLHGLPMTVKDAIETAGIRTTGGVPELAEHVPDTDADTVARLRKAGAVIFGKTNVPVGSTDWQSFNPIFGCTNNPWNVDRTPGGSSGGSAAALAAGLAGFELGSDIAGSIRTPAHYCGVYGLKASHGIIPAHGHIPPSPGGLGEMDLAVLGPMGRSPEDLDLGLDILSGAAPERAVAWRLELPPPRATSLADFRIAAWLDDPYCTVDREVLEVMQDAVEAIRKAGAKVDDTARPVGLEESHRVYLGLLMGVGAGVLGDEEFGAALAMEAEEIDAVFHPRLVTQRARDWHRYDEERHRIRARWAEFFKDHDVLLCPVVPTAAIPHDHTPEQEDRRTTVNGETRSYLSDMTTWSGLINMPLLPSAMAPIGRTRSGLPVGIQIVAPYLEDRTATGFARLLRDLLGGFQPPPGYAHHEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D042</accession>
    <name>A0A1H6D042_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted metal-dependent hydrolase, TIM-barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78662">
        <property type="protein sequence ID" value="SEG78662"/>
        <property type="gene ID" value="SAMN04489712_112108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="7"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="297" mass="34158" checksum="B6C2385956190663" modified="2017-01-18" version="1">MADLPFVDTHVHFHDLGHPRLRYEWLEPDAPHDPVVGPDEAIRARRYWADDFVAETRFHNVHKVVHVQAAIGTDDPVEETRWLQAFADRLGVPHGIVGYADLTRPDTAETLARHAEFPNFRGIRDLRYDAYLTDESWLRGYALLERHELVCCDDPLLEQFPEARRLAERVPGVTLCIDHAGYPRHRDSEYFRRWRDAMRDIAKAPNVVVKISGLGQADHRWTTASLRPWVLECIDAFGTERAFFGTNWPVDRLYSSYGDVVNAYADIISDFAEAERRAMFSGNAERIFRLGTEEAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1H4</accession>
    <name>A0A1H6D1H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_112135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78868">
        <property type="protein sequence ID" value="SEG78868"/>
        <property type="gene ID" value="SAMN04489712_112135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG78868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="215" mass="23404" checksum="54A0FCC1813383D9" modified="2017-01-18" version="1">MGEVVSIAVVDDQDVVLSGVRAWVTEDLAGRVEIVHTATDLGGLDSGPAATADVLVIDLRIGGELVFDQIAELAKAGRRIVVFSQHAEAECVHRAEMAGAHAYITKESNEGQRHLIEAILAVAAGDTYTTPSQAGAMLADTRRDRPRFSEQELRTMRLWLGGLTRAAVARQMGISEHTVKQYLARAREKYAKAGREVPTRIDLYREAQRDGIVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2P8</accession>
    <name>A0A1H6D2P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol-disulfide isomerase or thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79278">
        <property type="protein sequence ID" value="SEG79278"/>
        <property type="gene ID" value="SAMN04489712_112193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="14781" checksum="461217D559B6007D" modified="2017-01-18" version="1">MTGAFVAALVLLTATVFGLVRRRRDGRLRAGKGSGLDGSRDRLSPAELGAELGERATLVQFSTAFCAPCRTTRRVLADVAAMVDGVAHVEIDAEAHLDLVRRLGIVRTPTVLVLDAAGNVVRRAAGAPRRADVIAALGAAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2Q6</accession>
    <name>A0A1H6D2Q6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_112143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78936">
        <property type="protein sequence ID" value="SEG78936"/>
        <property type="gene ID" value="SAMN04489712_112143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG78936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="168" mass="18925" checksum="21AFF45BA8FEA7B3" modified="2017-01-18" version="1">MVHLIRNSLRPVPRKHRAAVAAELRKVYTAPDAALDALAAFAGTDLGRRYPQAARIWETAWERFVPFLAFTPAVRKLLYTTNSIESLSYQLRKVTKARGHFPTDDAVVKLLWPAIVNIEDKRARQRAARARQDGIRAGYPGRLIEGTKTYGWTDALNELAAAYPGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5N4</accession>
    <name>A0A1H6D5N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_113105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80571">
        <property type="protein sequence ID" value="SEG80571"/>
        <property type="gene ID" value="SAMN04489712_113105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019139">
        <property type="term" value="F:cytokinin dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009690">
        <property type="term" value="P:cytokinin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015345">
        <property type="entry name" value="Cytokinin_DH_FAD/cytokin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09265">
        <property type="entry name" value="Cytokin-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG80571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="382" mass="40922" checksum="459A3965DD17CF60" modified="2017-01-18" version="1">MIGDFGGIVRLIPRQTVRPATAGEVAAVLRAARVPVVPRGYGHSTYGQAQVADGVLLDMRGLRTVHEVRPDRVVVDAGATWREVLDATLPRGRTPPVLTDYLDVTVGGTLAAGGVGGTSHRYGVQADQVLALEVATPAGEVVTCSPEENRALFDAVRAGLGRHGVITRAVLRLVPAPERVRSFKLLYATAGALLDAQRRIPADHISGQAKLGLGLRYELTAVCHDPGRRIDGAFEEEELPYAEFADRMRPDVEELIRLGEWARPHPWGIVFLPARRAAEVIETTLAETGPTGLGLSGVVLISPLTVRDVPALRVPADPVMFALLRTASPGAASPDAMVAANRRLHERARRVGGTRYPIDAAPPDPHRPVRTPPPEGADQESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6A2</accession>
    <name>A0A1H6D6A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_113180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80937">
        <property type="protein sequence ID" value="SEG80937"/>
        <property type="gene ID" value="SAMN04489712_113180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="971"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG80937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1309" mass="141699" checksum="93147EFB38FCF49B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6M8</accession>
    <name>A0A1H6D6M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_113179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80931">
        <property type="protein sequence ID" value="SEG80931"/>
        <property type="gene ID" value="SAMN04489712_113179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="71" mass="7941" checksum="AC1D8578AAB8E2A5" modified="2017-01-18" version="1">MTNPFEDPDGTFLVLVNDEGQYSLWPSFAEVPAGWTVAKTADTRQACLDYVEANWTDMRPKSLVEAMEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8N8</accession>
    <name>A0A1H6D8N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81797">
        <property type="protein sequence ID" value="SEG81797"/>
        <property type="gene ID" value="SAMN04489712_114145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="421" mass="46742" checksum="4B3C34515F2868FC" modified="2017-01-18" version="1">MEFQAGRGEWFCALEWARLLGHRGQREQALEVLAPYIATNWWPAARARAELLEGWGRVEEAIAVSRPYAEAGDRLALVFFARLLARHGHSGEAFMLLRAGIQDWFLAECLVDVAEAAGMDEEAAALLESRVEAAVPACNDPDCNNLRMEPSNAVDLLATIRERQGRIEEAIALLHTREATSVNGRDQLADLLARHDRITELRAYAASEFHGHAVQRLAEVLEERGDVEGAIAAYRTFGATPDGMWHVAVPLSELLVRHGRGDETIEVMRALAERPGGAEDWIVHTLCTLYADHGRPRDGLAYLDALKARSGGKEEWDFFRMRLPLMADCGLLDEAIEQARAHAEGDTWYAAWALSDVLAEAGRTEEAAAVLEQHPTFNSSLRAERLIDLGRIEDAVRVLRQPRTKPITPAWDGAYSTEPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D993</accession>
    <name>A0A1H6D993_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81772">
        <property type="protein sequence ID" value="SEG81772"/>
        <property type="gene ID" value="SAMN04489712_114139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="416" mass="45499" checksum="51751D981AE47B82" modified="2017-01-18" version="1">MTSSIPAERGRLGEDGDERTTPERSAEPEVSERPCGYCGRPVPQRPGRGRPREYCAGSDCQARAKRERELRRATPGLEGALARAEDLYERMEQGLAAVLAPLAQALESELSPRGVEARVSAVRAEAQAQVAAAMAGREEATDRAVQAEEAADKARERARAARQRAQEAERERDAALETAERERAEAAASVQAAHEEAERTVQAVRREADGLVRAARQEAERAVAEARAAAEQAQTEAAAASRDAQEARREADAALRQARQARTQAEAAREEAARADREQAVAQARAQAAEEARERAEARMQAAEESRERAEARAQEETTLRAGAVAEAERAQAMVQDATRAAERYRAEAATAGQEAERLRRELEETRAELRAERLRADGLERDRDQARAEATAQRERAVVAELQALRARDRPEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAJ8</accession>
    <name>A0A1H6DAJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR C-terminal helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82351">
        <property type="protein sequence ID" value="SEG82351"/>
        <property type="gene ID" value="SAMN04489712_11513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="274"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="34886" checksum="C1C54B395F30FED1" modified="2017-01-18" version="1">MKELAGRLAALDPDAGAAMQVITYFDRLLEGRAGLAALVRGAAVLTGHPVRLADEPHRVFVRVDAEGRRMDGGGLPDPAWPSAPLEPDGPPALWLERPGPAGVVEAMVLERASAAIRTVLVRTRGWAHEAAPDQAMTEVLLDAAAPRGARLRAARRLGLDVAGRARAVALAGGAARVQAVDATRPDAVDAGDERAGIGPAVPVADLPESLAAARTALRFTAEGTDRDPGPRVVHADRLGGLAVLASAVGPDTEPVPDVRALERAVAAAPWMLVTLDAVATGSSLRAAAAAINVHHSTLQDRLAGAEHELGWSVHDPQGRLRLQLALALRRLHRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DC06</accession>
    <name>A0A1H6DC06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82343">
        <property type="protein sequence ID" value="SEG82343"/>
        <property type="gene ID" value="SAMN04489712_11512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295724" evidence="2">
        <location>
            <begin position="32"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="627" mass="66567" checksum="07F66D0C3B959E00" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DD46</accession>
    <name>A0A1H6DD46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_115166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83189">
        <property type="protein sequence ID" value="SEG83189"/>
        <property type="gene ID" value="SAMN04489712_115166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="15060" checksum="9CE6A0DA5F2BF14F" modified="2017-01-18" version="1">MGRAGAARDVRRLLEAGLRLVHLGAEGTGISEQAFLEVERLAVELSRRHGRLRFVGMLAVVVQRGVGELARLTGRSPEDIAAEHTGFCPDRGLREWMAEVMRAPAGAAWSPPPADAPIAPAMALVHLHVTVCLALCGAPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE54</accession>
    <name>A0A1H6DE54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83501">
        <property type="protein sequence ID" value="SEG83501"/>
        <property type="gene ID" value="SAMN04489712_1167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025361">
        <property type="entry name" value="DUF4265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14085">
        <property type="entry name" value="DUF4265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="18963" checksum="2EDFEBFB0A0A1B4F" modified="2017-01-18" version="1">MASREPAYERQPVFVTHQDPVGRAEQNQIAQADLAPYGMADQVEQLWLLDQGNGTYALACIPFCVHGLALHDRVRLSDDGRWVTGLVEPSGHRALRMLWTPTTDHAQLTHRTARVKTEIATAGLLSEWRGRHVAIDLPPAIRPQPLLALMAQEVDAGQASWKWADTEPFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEQ6</accession>
    <name>A0A1H6DEQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_115165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83185">
        <property type="protein sequence ID" value="SEG83185"/>
        <property type="gene ID" value="SAMN04489712_115165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="242" mass="25936" checksum="4903A53EF337E96A" modified="2017-01-18" version="1">MAAGGAFVPKYVQIVETLRRRIKDGTYPIGSKLPSEADLVREFGVSRPTVVRSLQEMALLGEIEREHGRGSFVRAVAENREERRPALAVLDRQETDDSVKVVQVGPEAAPARVAARLGVVEGARVHLRRSVSFLDADTPGEVVSVWTPLDVAKAAGLEPSGPLTVPLRRLLTAGTGERLSHVTELLTARHPVGSEAELLGIAPDEPVLGVLASVVDATDRVVLVVEVVLPGSLHDLEDTYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGV7</accession>
    <name>A0A1H6DGV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2786 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_116117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83983">
        <property type="protein sequence ID" value="SEG83983"/>
        <property type="gene ID" value="SAMN04489712_116117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="1">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="27439" checksum="2A5B0E0A66D8C7C9" modified="2017-01-18" version="1">MDAERIEARVRALLARAEHPATPRPEAEAAHAKAAELMLRHALDEAALRADQGQVPDPAVYWERIAPGGGGHARARTAAAGAVIKAYGGRYAVRGDGTRGQDITLLIVTTRAARDALLLLLPSLELQMEGAGRRETDAYMATVPKDAFARRSDRSRWANNYFRAFIVGYGDAVARRIEQARQGLLAQDGGGSSRALVLAGEDRRVAAEFAARFPELGRPRVQRLRADGYRAGRVAGDRADLGDGRLGASRPAITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DHT5</accession>
    <name>A0A1H6DHT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein DedA, SNARE-associated domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84780">
        <property type="protein sequence ID" value="SEG84780"/>
        <property type="gene ID" value="SAMN04489712_11767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG84780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="26873" checksum="C6CD976E1E58AFC9" modified="2017-01-18" version="1">MIDQVLEGLRGAVTSPWFYAALLAFACVDAFFPAVPSESLVIMAGVYAASGEPNLVGVVACAAAGAFVGDHVAFWMGRSSRGRVSRWRRRTRRGRALERAERTLRRRGGLVLVVARYVPGGRTAVTVTMGAVGYPARLFVVFAAVAAVSWAWYAALAGYVGGRAFEEDPVRGLLVGFGLAVGITAGVESARFAWSRRAGRAGRGARRGATPLPAGTARDGADAAGGVGCAGTLRSRPASTRSIRSCPRFGDLRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKF4</accession>
    <name>A0A1H6DKF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85599">
        <property type="protein sequence ID" value="SEG85599"/>
        <property type="gene ID" value="SAMN04489712_11842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296064" evidence="4">
        <location>
            <begin position="39"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="5">
        <location>
            <begin position="63"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="6">
        <location>
            <begin position="453"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG85599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="732" mass="77543" checksum="FC7A3ACB638D6D12" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKS2</accession>
    <name>A0A1H6DKS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85739">
        <property type="protein sequence ID" value="SEG85739"/>
        <property type="gene ID" value="SAMN04489712_11870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="500" mass="53210" checksum="2A8B8B610687FBC0" modified="2017-01-18" version="1">MAPDHSNAVPSPDDTGAPPAVQPDAHPGRTQHRVLTALAGLGVAALAAGTFVLTYEDLRTLALAGGAARRWAPVYPVLVDVLIVVTVLALVATRHARWWSRWPRWALLLVVVAGAAAASVQRAVKGYEALPDDPLKVGVAVAPYVILVIVTWLWLAMFRQFRRSSPRRAAPAPAPEPVDDPEPEAPAPPPLAVPAPRSDDTWLFGDTDDETREDSRVPDVSPDEPEPVSYQTAAHPPEPLPYQATAHPHPPEPARPVTPLFDSPEPPRPIAPVFDSPEPPQPIAPVFDSPEPFPGEAPPLESIPRKAPPMEPVSRKAPPLEPLPNEAPPLEPLPGEAPDLEPLPSEARDLESPEPLHDVAQDWDPAAPYSDDPAPQTSEPSRDVDIDDDPTPPIEFPSLLPTDVELVRGGARPAVKPAATTRPDIVMPTEQELANGHPVPEPDPAEDDDAPVVDRAEDPDGGGEDPVPSSDDLVTGAEDDPAEPSPPSGSLRSSPIPPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLU2</accession>
    <name>A0A1H6DLU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86168">
        <property type="protein sequence ID" value="SEG86168"/>
        <property type="gene ID" value="SAMN04489712_1194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG86168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="38" mass="4055" checksum="7EE3E2E80284186E" modified="2017-01-18" version="1">MVEIDVAAAVRRASLGIRVIAHGWNHAFGGGRLPGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLZ8</accession>
    <name>A0A1H6DLZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86228">
        <property type="protein sequence ID" value="SEG86228"/>
        <property type="gene ID" value="SAMN04489712_11927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="37164" checksum="C67FA5A70A5DD3E2" modified="2017-01-18" version="1">MGPTRFSASSSPRHWDCRSEREVATIELQQLRYFVAVAEAQSISGAGTTLDVTQSTISQSVHALEKELGALLFHRTGRGMTLTSAGHGLLGPARRILRETRQAEAAVSAEPRRSAPRLDIAALPPTLNGPLAEVLAAFLRSNPGTVVHVHELGSEQEAAEVLASGTAEVVATRLPLDIGRTGDRLATLPLGTYDVYVAHPPSPGEEPATTGHEPPIGLTELHDVPLVLMPPRPILSAGMEAMIEESGPHLVRRAVVGQRETRTAWMLEGIAATLLGSRRAVEAARCGARLAPLRGVTDLTVGLAWDPRTTSPVARLFVASAHAATTRSPAAPGPPASTAPGDGPVQPGGTPAGPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNW0</accession>
    <name>A0A1H6DNW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Long-chain-acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86225">
        <property type="protein sequence ID" value="SEG86225"/>
        <property type="gene ID" value="SAMN04489712_11926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG86225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="381" mass="41908" checksum="98FA9C0C0F90776E" modified="2017-01-18" version="1">MQTSIYHEEHETFRQSVRAFLEKEVVPRFPDWEAAGCVPHEVYQKLGDLGMLGLRVPVEYGGGGEDSFLYSSVWSEECSRAGVSLGGAATHMNLVIPYILHQGTEEQRKRWLPDMVAGRRMGAIAMTEPGTGSDLAGIRTTARLEGDHWVLSGSKTFITGGINADLVVVVARTSEHANRRVGLSLLVVDANSEGFSRGRNLEKIGLKATDTAELFFDDVAVPVDHLLGEEGQAFRYLAHNLVQERLGIALGAQVSAEKALRITVSYVKDRKAFGQPVSSFQNTKFKLASCHVEVTAGRALLDQAMRAHEAGELTAAEASTVKVYCTEMQNRVIDRCLQLHGGYGFMREYEIARMYTDSRISRIYGGTNEVQRVIIAKALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPT5</accession>
    <name>A0A1H6DPT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_120115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87342">
        <property type="protein sequence ID" value="SEG87342"/>
        <property type="gene ID" value="SAMN04489712_120115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="260" mass="27673" checksum="C937EB962165308C" modified="2017-01-18" version="1">MLTEEQRRDAADRLREAELNRAPIPPLVETFPGIDAVDAYEIQLINIGRRVAAGAVVGGHKVGLSSKAMQQMMGVDEPDYGHLLGDMALRQDEPVEAARYCYPRVEVEVGFVLGADLPGEDCTEDDVLAATERVVPALELIDSRIVDWRIALADTIADNASSAGYVIGAGRPPAGLDLTAIEATLYRDGEPVVSGRSDAVLGNPVTCVAWLARKVASFGVRLRAGHLVLPGSCTRAIDVAAGQTFTADFTDLGSVSLTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRN4</accession>
    <name>A0A1H6DRN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_120120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87373">
        <property type="protein sequence ID" value="SEG87373"/>
        <property type="gene ID" value="SAMN04489712_120120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="144"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG87373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28603" checksum="8397703B3285BCCC" modified="2017-01-18" version="1">MNAGQWRGRGLGTRTAAYDEDEAILYALAVGASPGDLDLVFEERLRVLPTFALTRAQWAPDALGSAGAFDVTTAVHGSQRLRVRRPLPRSGELEMTARVAEVWDKGRAAIFEVVVDSAYFEATWSLFAPGRGGFGGERGPSARRRPDAPPDHELTVQTAPNQAALYRLLGDRHHMHIDPEAAKTAGMPRPFLHGLCTLAAVTLPLAEAAGAHPADLVELEGRFAAPVFPGDRLQVTGWNDGEAVLFEAAVDGTTVVSGGRAQFRVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSA7</accession>
    <name>A0A1H6DSA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG88118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88118">
        <property type="protein sequence ID" value="SEG88118"/>
        <property type="gene ID" value="SAMN04489712_12180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="5">
        <location>
            <begin position="164"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG88118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="27605" checksum="71402BAE8E7CCFB5" modified="2017-01-18" version="1">MRVGFIGLGSQGAPMARRIIDAGYPMTLWARRPASLEPFADTSADVAASPAELAAASDLVCVCVVNDADVQEVVTGERGVLAGLREGGVIAVHSTVHPDTCRSLAEQAAAHGVSLIDAPVSGGGPAAAEGRLLVMAGGDAETVERCRPVFATYADPVVHLGDLGSGQLTKVLNNLLFTAHLATAASVLSLGRDLDVDPGRLAEVLSHGSGASFALGRVAAAGGTLERMASHAGPLLQKDVRLVADLAEAAKATPGTVLETADAALALMGHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTV6</accession>
    <name>A0A1H6DTV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88708">
        <property type="protein sequence ID" value="SEG88708"/>
        <property type="gene ID" value="SAMN04489712_12263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG88708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="254" mass="26318" checksum="A8935B9D1C6100AA" modified="2017-01-18" version="1">MSDEVLVEHSGGVTVITINRPQARNAVNRAVSDGIAAALEEFESRKDLTAAVITGAGGTFCSGMDLKAFVAGENVVHPERGFAGIAHKPPRKPVIAAVEGYALAGGCEIALACDLIVAAEDARFGIPEVKRGLVAGAGGLLRLPRRVPYAVAMRLALTGDFLTAPEAERHGLVTEITAPGKALEAARALAEAIAANAPLAVAATKEVIVASADWSSDEAFAKQDQVIHPVLTSADAREGATAFAEKRPPVWRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVJ7</accession>
    <name>A0A1H6DVJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89301">
        <property type="protein sequence ID" value="SEG89301"/>
        <property type="gene ID" value="SAMN04489712_12362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="324"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="412" mass="46974" checksum="71600191BB9A232E" modified="2017-01-18" version="1">MSSATDPHGRVDEDGTVYVKTADGGERVVGSWQAGAPEEALAYFKRKYEALVTEIELLEQRVRTTDLAPAQAEQSIARLRESVTDAHAVGDLDALARRLDSLGELVGKRREEVRAQREHARHEAREVKERIVAEAERIAAEETHWKNGGERLRQLVEEWKAADRIDRPTETALWKRLSAARNAFTKRRKAYFATLEDQREQARVEKERLVVEAEAMSGSTDWSETAAAYRDLMRRWKSAGRAGRDTEEELWARFKGAQDTFFAARAAAYAERDHELRGNAEVKEHILTEAERLLPVRDVRHARQALRSIQERWEAAGPVPRDSRDRLEGRLRKIEDAVRAAEEAEWRRTNPEARARAEATVGQLRSSIEQLEKRLAKARDAGRDKDAKDAEEALAARRAWLEEAERTLAEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXF3</accession>
    <name>A0A1H6DXF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyphosphate kinase 2, PA0141 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90030">
        <property type="protein sequence ID" value="SEG90030"/>
        <property type="gene ID" value="SAMN04489712_12518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="5">
        <location>
            <begin position="12"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG90030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="32198" checksum="C581FFD4212372CA" modified="2017-01-18" version="1">MNGPEKARRLPRRLYAEELLRLQAELVKLQEWVRAEGARLVVVFEGRDAAGKGGAIKRITEYLNPRVTRIAALPVPTERQRTQWYLQRYIEHLPAAGEIVLFDRSWYNRAGVERVMGFCTEQEYRRFFHQCPIFERLLVEDGILLRKYWFSVSDGEQERRFRARLDDPLRCWKLSPMDLESISRWEDYSLAKDDMFVHTDIPEAPWYVVEADDKRRARINMIAHLLSTVPYQDVRPPELELPARPPSRGYRRPSRDTQTYVPDHAATLISGDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXP7</accession>
    <name>A0A1H6DXP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89844">
        <property type="protein sequence ID" value="SEG89844"/>
        <property type="gene ID" value="SAMN04489712_12487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="255" mass="26771" checksum="193B61AC1B425200" modified="2017-01-18" version="1">MAAGLSGMELARRAGVPQPTVSRVETGRRVADVEVVVRLLGGLELAPAELERLASVVREAYAGSVPRRVDAGVSFRRGLAVELERAASVVRSFEAMVVPGLLRTAGYVQAAKPVSAGDGVERSAVLGDEGRRFTFVISEHVLRTWPGSGACMPGQLAHLVAVAGRPNVRLGVVPAGVGVDSGWSGVPLHGFTLYDEAAVTVETFTRELTLTGEADVRAYVEIFKGFARSAVFGDEALGLVERAGRDLGKALGSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ88</accession>
    <name>A0A1H6DZ88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-related amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90491">
        <property type="protein sequence ID" value="SEG90491"/>
        <property type="gene ID" value="SAMN04489712_12654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="22117" checksum="6473CF526188D372" modified="2017-01-18" version="1">MSLDRWLGTGRTPALLVSECQNGLINPEYATTMAGLARQAAERDIVSKIARLAGSFRSAGLPVAHATIEPAADWAGFDLSSPLAAHTRRRDEFKEGTPLPLIHPGLRPHEGDLLFPRRTGMTAFFRSGLGAALRERAVDTVVLVGISTNVAIPGTTVEAVNRGLPVVVVEDATAGTSDEVQRFTFTHVLPALATISTTDDVIAAIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3W6</accession>
    <name>A0A1H6E3W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91969">
        <property type="protein sequence ID" value="SEG91969"/>
        <property type="gene ID" value="SAMN04489712_13149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_dim" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="12312" checksum="77EE4F03E964ECB4" modified="2017-01-18" version="1">MPQVVFTEPEIASVGLTAAAAVAAGLRTRVVYHDLGAVAGSALHADGYRGHARMVVDEDRKVIVGFTLAGPDVAELLHAATIAVACEVPLDRLWHAVPAFPTVSEVWLRLLEAYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7M6</accession>
    <name>A0A1H6E7M6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="9" type="ORF">SAMN04489712_13727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93149">
        <property type="protein sequence ID" value="SEG93149"/>
        <property type="gene ID" value="SAMN04489712_13727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="28"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG93149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="477" mass="53118" checksum="1314D1FE564BBB9A" modified="2017-01-18" version="1">MTPQSEDFSAWYNELVIKAQLVDRGPVRGTMVIRPYGYRIWELLQADLDRRIKEAGHDNACFPMFIPESYLRREAEHVEGFSPELAVVTVAGGKELEEPLVVRPTSETVIGEYMAKWIGSHRDLPLLLNQWANVVRWEMRPRMFLRTTEFLWQEGHTAHIDEADAMRETMWALDAYAAVARDLAAMPVVPGEKTPGERFAGAVRTYTIEGMMRDGRALQAGTSHYLGTNFAKAFEIQYQDEAGKLTLAHTTSWGMSTRMIGGVIMTHGDDTGLVLPPRLAPYQVVIVPIGRKEQGEATAAEARRLGAAIKSMGIRVHVDDNRPQLSPGFKFNDWEMRGVPIRLEIGPRDLENGVATLVRRLPTVEGQGKEAVPLERVPEIMPQILADFQAFLLARAETFRGDHTRAVEVWDDFGAQVAEGWALAFHCGRAECEDDIKADTAATPRCIPAEGPAEQGVCVKCGQPSAYGKRVIFGKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8J2</accession>
    <name>A0A1H6E8J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94138">
        <property type="protein sequence ID" value="SEG94138"/>
        <property type="gene ID" value="SAMN04489712_14320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="317" mass="35872" checksum="84FB0AC6073E2E42" modified="2017-01-18" version="1">MDVRDAARRKERGERLRASSEVFEVAIDSCAHVWQAGRLKRRSIEIRTCFIVGDPNGRTAPLSRLIRPRGIAWQVYLLALFEAQCSRTGGSAVLANKRPLVPSRPGEVAWSNLVLPEMREALIDQSKVERQLKTALTALEKVDLVVLPERPRARNRCQGFRLLHESAESTRVTPVMYTVPDRNEPRIALPVDFFTKGWVHVLSPAETAVYLMLRHLKLKYPREHDLKGVYAAEAVREGVYGIRRDTYERHRELAAYGLIQLIPDPSRRPDGKIRGYRAGEDGSPLNHRFQVLPDSALRRNALEVVASSSVRANASMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8J4</accession>
    <name>A0A1H6E8J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93459">
        <property type="protein sequence ID" value="SEG93459"/>
        <property type="gene ID" value="SAMN04489712_1394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="140"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="348" mass="37344" checksum="B6A828A047CA903F" modified="2017-01-18" version="1">MAGTAIVVGAGVSGLATAIGLRRAGWEVSILERRAEPERYGTAFGIHPTAQSALDRLGVGQALSDRAVPYRGARIRTPEGSVMASLPLERIERRAGRPELLISRPYLIDALMAELDALGSASPKFGEAVFDVGSLVAGNDLVIGADGIRSVVRTACFGERSGPRPIGTVAWIGIADFESGVYGETWGSGRFFGMTPIEPGRTNWYAIVPEAGTEGELRGHFEGWHDPIPRILAETDPSTWIRYEMRHLFPALPTFVHGGKVALVGDAAHAMTPNLGQGACTAILDAEALARAVAEHGPTGLPSALRAYDAERRRSAQRVAFASRNLHRLMTTEHTRLRASLLRLLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9D2</accession>
    <name>A0A1H6E9D2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_14615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94327">
        <property type="protein sequence ID" value="SEG94327"/>
        <property type="gene ID" value="SAMN04489712_14615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG94327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="545" mass="57944" checksum="E3C1B2A9D8D77744" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9H1</accession>
    <name>A0A1H6E9H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_14712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000047">
        <property type="protein sequence ID" value="SEG94410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94410">
        <property type="protein sequence ID" value="SEG94410"/>
        <property type="gene ID" value="SAMN04489712_14712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="42597" checksum="81B0A7FA27624364" modified="2017-01-18" version="1">MLTRRFGDFDAAEDAVQEALLNAAAQWPAEGVPGNPRGWLIQVASRRMADQLRGEQARRRREELVAAWSPPDRRVAPPADDPDAAGRDDTLTMLFLCCHPTLTPASAIALTLRSVGGLTTAEIARAFLVPEATMAQRISRAKQRIKSSGVPFRMPGPDERARRLASVLHVLYLIFNEGYVGSAGPELQRVELAREAIRLTRMLHRLLPGECEVAGLLALMVLTDARRPARTGPDGAPIPLAEQDRTLWDAEAVAEGIALVTAALARGAVGPYQLQAAIAAVHDEAPTAEDTDWPQILALYGLLERMSDNPMVALNRAVAAAMVHGPATGLDMLRALDADGRLAGHHRLHAARAHLLEMAGDHEAAVAEYRSAANRTTSIPERDHLITRAAHLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB19</accession>
    <name>A0A1H6EB19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000045">
        <property type="protein sequence ID" value="SEG94269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94269">
        <property type="protein sequence ID" value="SEG94269"/>
        <property type="gene ID" value="SAMN04489712_1454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="11582" checksum="84465CCDBF3F8562" modified="2017-01-18" version="1">MPTITGAGRTTPGQNWQNYTDGPGIYLDVNTSSAGFNPALGTPVYTISLGGNQRMWYLAGSSSVYEPTVTGFRVYLRKLELEDGELTVNDAQQWGLHINWIGAQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S363</accession>
    <name>A0A1H5S363_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ORF">SAMN04489712_10161</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF45042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF45042">
        <property type="protein sequence ID" value="SEF45042"/>
        <property type="gene ID" value="SAMN04489712_10161"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SEF45042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="251" mass="24281" checksum="3279F3051C1E1125" modified="2017-01-18" version="1">MTDGPRLAISLLTVVPVRAGRIDPRTAGRAMLLAPAVGLLVGGAGALVMAAGDLLGLGGLLRAALALAAMALLTRALHLDGLADLADGLGSGRPAAGALEIMKRSDIGPFGVVTLLLVLLVQAAALAESPHGAYAVILAAVAGRLAFPWACRDGVPAARPGGLGATVAGTVRTPDAVAVTVVVLVIAMACGALLGGVPGIALSGLAVAAGLGAALLLLGHAVRRLGGVTGDVLGALAETATTAALVVLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SGU4</accession>
    <name>A0A1H5SGU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49011">
        <property type="protein sequence ID" value="SEF49011"/>
        <property type="gene ID" value="SAMN04489712_101177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="13581" checksum="3DBDF95065425281" modified="2017-01-18" version="1">MAIRDKMQANAAPFLRPGETVQAVFGAQTLSQYYIVISALILFIWNSYRVVVVTDQRILVCRSGKFTTTPVKEVLRELPRRTRIGPASGLWWRCEALGERLYVHKRYHKDVAAADAVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SKR6</accession>
    <name>A0A1H5SKR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ORF">SAMN04489712_101256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51189">
        <property type="protein sequence ID" value="SEF51189"/>
        <property type="gene ID" value="SAMN04489712_101256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF51189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="334" mass="36594" checksum="9498991BD107B9C7" modified="2017-01-18" version="1">MHDRVSAPQAGHIPVLLDRVLSLLAPAVESVPPGRDPVYVDATLGLGGHAEAMLQAHPRLRLIGLDRDPSALERSARRLERFAERITLVHAVYDELPRVLADLGEPHADAVLFDLGVSSPQLDEGERGFAYSYDAPLDMRMDPTQSLTAAEVVNGYPAEELARILREYGEERYARRIAAAIERERAREPLRSTARLAELVRAAIPAATRRTGGNPAKRTFQALRIEVNGELTIWRRALPAALDALPVGGRVVVLSYHSLEDRITKRVLAEHSTDTTPPGLPVPLPDRQPRFRLLTRGAELPTDEEIAANPRAASVRLRAAERIREPVTGPGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5STR3</accession>
    <name>A0A1H5STR3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">polA</name>
        <name evidence="15" type="ORF">SAMN04489712_101363</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54002">
        <property type="protein sequence ID" value="SEF54002"/>
        <property type="gene ID" value="SAMN04489712_101363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="13">
        <location>
            <begin position="12"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="12">
        <location>
            <begin position="312"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="14">
        <location>
            <begin position="655"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEF54002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="899" mass="98177" checksum="34170A5F667FEA2C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T2E8</accession>
    <name>A0A1H5T2E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacid CoA-transferase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56217">
        <property type="protein sequence ID" value="SEF56217"/>
        <property type="gene ID" value="SAMN04489712_101432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF56217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="215" mass="22369" checksum="C46D41072B69A34B" modified="2017-01-18" version="1">MAWTRDQMAARAAAELTDGSCVNLGIGLPTLVPGHVPPGVRVVLHSENGVLGVGPYPREDEVDPDLINAGKETVTVLPGASYFDSALSFGMIRGGHIDTAILGAMQVSARGDLANWVIPGAMVKGMGGAMDLVHGARRVIVLTTHNAKDGTPKIVEECDLPLTGRRCVHRIITDLAVLDVTPAGLVLVETAPGVSADEVAERTGAKITIAEGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T5Q0</accession>
    <name>A0A1H5T5Q0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1998 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58192">
        <property type="protein sequence ID" value="SEF58192"/>
        <property type="gene ID" value="SAMN04489712_101496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1998" evidence="1">
        <location>
            <begin position="477"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF58192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="609" mass="68391" checksum="936ECA15C63BF864" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TVP4</accession>
    <name>A0A1H5TVP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66839">
        <property type="protein sequence ID" value="SEF66839"/>
        <property type="gene ID" value="SAMN04489712_101763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF66839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="26717" checksum="90E82D55254372AC" modified="2017-01-18" version="1">MDAERLRSLFDLSGRVAVVTGGTRGIGRAIAEGFVAAGASVVVASRKPEACAETETHLKAMGGSALGVPTHLGDLDALDTLVTRTVDTFGRLDILINNAANPLALPLGSFTPEAFAKSQDVNVRGPVFLVQRALDQLTESPCASVVNVVSAGAFLFSPYVSMYAAAKAAMVAYTRSMAAEFASRGIRVNALAPGTVDTDMVRNNPPEFQTAMEQASLQRRMADPDEMVGPALFLASDASSFVTGQVLIADGGLVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TXV4</accession>
    <name>A0A1H5TXV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crotonobetainyl-CoA:carnitine CoA-transferase CaiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67599">
        <property type="protein sequence ID" value="SEF67599"/>
        <property type="gene ID" value="SAMN04489712_101786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF67599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="429" mass="47540" checksum="19D730089EBAA5F9" modified="2017-01-18" version="1">MSTPLDRRPRKRRGPLAGLVVADFCWMGVGSVATRLLADFGADVIKIEDRSRLDMPRRLPFYKGEVRTYGEEDPNPDPDKGGLFNNYNRNKLGVTINMRTERGRRIAERLISQASVVTENFAPGVMERWGLTYERLRELRPDVIYGRMSGYGHEGPHSEYRSYGPVIQAVSGLTHISGLPGREPSGWGFSHMDNQAAYYNSAALLMAVLQREITGQGTEVDVSAVEVGINLLGPVMLDVAVNSRSTRGADFPTGNRLEHPQAAPHGVYPAAGEDRWVAIAVFDDADWKALVTELDAAEWAADPRFATQAGRFAHQDALDEHLSAWTRERDPHKIMHRLQAAGVAAAAVQHAGDLNERDPQLAHRGTFFELDHPVIGEARFEGSPVLFSGIEPDHWRSAPLLGEDNEYVFTTLLGMPQEEIAELTREGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UUU1</accession>
    <name>A0A1H5UUU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_10239</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78819">
        <property type="protein sequence ID" value="SEF78819"/>
        <property type="gene ID" value="SAMN04489712_10239"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
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        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PGDH"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="455"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEF78819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="529" mass="55690" checksum="D738014D7D692D82" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V7Y2</accession>
    <name>A0A1H5V7Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nickel superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82871">
        <property type="protein sequence ID" value="SEF82871"/>
        <property type="gene ID" value="SAMN04489712_102186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036502">
        <property type="entry name" value="NiSOD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014123">
        <property type="entry name" value="Superoxide_dismutase_Ni-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09055">
        <property type="entry name" value="Sod_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109770">
        <property type="entry name" value="SSF109770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02753">
        <property type="entry name" value="sodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF82871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="15489" checksum="57D28EDBEA999C4C" modified="2017-01-18" version="1">MQVLAKLLRPKTTVSAHCDLPCGVYDPAQARIEAESVKAIIEKYHANEDPVFRTRALIIKEQRSNLVKEHLWVLWTDYFKPPHFEKYPQLHQLFNEATKLAGAAGTKQSMDVKVAEDLLAKINEISEIFWETKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V802</accession>
    <name>A0A1H5V802_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83314">
        <property type="protein sequence ID" value="SEF83314"/>
        <property type="gene ID" value="SAMN04489712_102203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="223"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF83314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="444" mass="47677" checksum="9AFD636897DD49D5" modified="2017-01-18" version="1">MRGLPPAAWAYVSGVVALAAVAIATTPLADLDPQTLAVLAALFLICDSAPAKLNVERARVSLSYAASLASVVLLGPDGAALVGVTAIVTGQRIFAPVKRLFNGAQFALSGYAAGMVFGALGGDRYRPGQAEWVEHVIGPFLGALVAFVTVNLLLMAGILLISRQAAWQELLRESGELVFGCLGYGMFGLLIAGLWDAVGPFAAVLVLLPLFIARWALAQTHAQQQAHTATLAALCQAVETKDYYTRGHSERVSRGSVMIAQEIGMRADRVAAIRYAGMLHDVGKLGVPTKVLQKTGPLTEEEFAAIQLHPMRGLEIVREIGFLDEALAGIMHHHERMNGRGYPMGLAGDEIPEFARVISVADAFDSMTSTRSYRAARTKEEAIEELRRGAGDHFDPVMVEAFLRALEREGWEPPQPVVLPDDDVVETTQQDHDDPSVPIRIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VAH4</accession>
    <name>A0A1H5VAH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84204">
        <property type="protein sequence ID" value="SEF84204"/>
        <property type="gene ID" value="SAMN04489712_102235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF84204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="378" mass="39708" checksum="CCC9005E20C69518" modified="2017-01-18" version="1">MATGKVRPRRSTAPVVAVTGAASGAGRLLARRLAVSDEVRKVVAIDGHRGDAPGVLWRVANVRDPMLSNRLADVDVLVHVDVDRSPDTDPRERRTYNVRGAQTVVTACAAARVRHVVLVTSAMVYGAATDNPVPLAEDAPLNAEANASIVGDYLEMEEVAAQAPLTHPGLTVTVVRPAALVGPGVDTVMTRHFEAPRLLAVKGRSPCWQFCHIEDLAAALEQIATGALTAGPGSGAAPGNAGDRTPTAIGVGCDGWLELEEVEEITGKRRFELPAALTFGTAQRLHRLGLTPAPATDLHYVAYPWVVDCATLRSAGWKPAYDNASALRVLLEETAGRHAVVGRRVGGKEATMATAAGATVAVIGAAAAVRRARKRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VMT1</accession>
    <name>A0A1H5VMT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88609">
        <property type="protein sequence ID" value="SEF88609"/>
        <property type="gene ID" value="SAMN04489712_102385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF88609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="19126" checksum="3E272914DBADAC91" modified="2017-01-18" version="1">MRTPAERRAEPADPLTVVHTRWAEEGMAGGPWPFLAMCSLSRLHQILARALEDRLKSLELSRTGYFVLTTLALMNGGRALLSTLGRLMMIHPTTVKLTVDQLERAGLVTRQRHPHDRRATVVRITELGAERARAANAALENADEGPLGGLAGRHEELFDALRDLRLATGDTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VS50</accession>
    <name>A0A1H5VS50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein YloU, alkaline shock protein (Asp23) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89347">
        <property type="protein sequence ID" value="SEF89347"/>
        <property type="gene ID" value="SAMN04489712_102411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF89347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="13434" checksum="1F053CDAAC36D27D" modified="2017-01-18" version="1">MSTGLLRSDHGTTVITDRVVTKIASRAVAEMEQAHGTGRSILGVRLGRARRARVRATLDGSMAVARVEISVEYPTSILAVTRQARERIRDQIQSLTGLTVRHVDIDVTALEPPEPRRVARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VVR5</accession>
    <name>A0A1H5VVR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90667">
        <property type="protein sequence ID" value="SEF90667"/>
        <property type="gene ID" value="SAMN04489712_102457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="43"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF90667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="319" mass="34062" checksum="86F25D851426BFDA" modified="2017-01-18" version="1">MASRDFSLHGAVDLGARQAAAKRQQERRAQAGGGGAAGGGAGAAGGVHVVDVTDQTFNTEVVERSRSVPVLVDFWAEWCGPCKQLGPILERLAEEAAGQWVLAKVDIDANPQLAAYMQQMGVRGIPFVAVVVAGQLMPFLNGAAPEPQVRQAIGQLFEALRQEGILPEDGQAPAEGPGVMPEVDPAYAEAEAALQRGDMDAAKDAFQRILDSSPQDTEAKRGLALVELSRRVGGIDAGQALREADEQPGDVARQTRAADVELLSGRIEDAFERLVATVRRTSGDDRDTARKHLLSLFEVLPSDDPRVTQARRRLQSALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VW61</accession>
    <name>A0A1H5VW61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91101">
        <property type="protein sequence ID" value="SEF91101"/>
        <property type="gene ID" value="SAMN04489712_102473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="189"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="304"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="469"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF91101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="560" mass="58116" checksum="FDE9223432327264" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W9S6</accession>
    <name>A0A1H5W9S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-N-acetylhexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95557">
        <property type="protein sequence ID" value="SEF95557"/>
        <property type="gene ID" value="SAMN04489712_102623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009288039" evidence="5">
        <location>
            <begin position="42"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="6">
        <location>
            <begin position="78"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="7">
        <location>
            <begin position="489"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF95557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="562" mass="58653" checksum="FD9B814DD3839FA0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WXD7</accession>
    <name>A0A1H5WXD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug efflux pump subunit AcrA (Membrane-fusion protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04289">
        <property type="protein sequence ID" value="SEG04289"/>
        <property type="gene ID" value="SAMN04489712_1037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009288812" evidence="1">
        <location>
            <begin position="25"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="127"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG04289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="358" mass="36806" checksum="1B6655329E3B9937" modified="2017-01-18" version="1">MARRIRTLALVAGGAVALGGAGWAAVGFGGADPAAPERSSLPPATATVERTTLVETEEVEGTLGYGAARTLSAARGGSSGQGLLTWLAGEGSTVSRGETVYKVDAVPVPLLYGKLPVYRTMRSGVEGSDVLQLERNLRALGYTGFTVDKTFSSATAEAVRQWQEDLGVTETGRIEPGSVVIASGRIRITDHKKAVGDPASGALLTYTGTTRMVTIDLDVDLQNLAEKGAKVTVEIPGGDSVEGRIAKVGSVATQQGGEAEEAEAASTIEVVVSLSDDRGLGRLDQAPVDVRLTADRERDVLAVPVAALLALPDGGYGVQVVEGSTTRTVAVEVGMFADGMVEVEGTGLGEGMKVGIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X0F2</accession>
    <name>A0A1H5X0F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flp/Fap pilin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05262">
        <property type="protein sequence ID" value="SEG05262"/>
        <property type="gene ID" value="SAMN04489712_10338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007047">
        <property type="entry name" value="Flp_Fap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04964">
        <property type="entry name" value="Flp_Fap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG05262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="6414" checksum="97D32EAE74F9B671" modified="2017-01-18" version="1">MVNRMITALAVRLQAARDRDDAGVTAVEYGLMIAVLVAIIVAAATALGGGITAAFDAAAEALTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X2S0</accession>
    <name>A0A1H5X2S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05660">
        <property type="protein sequence ID" value="SEG05660"/>
        <property type="gene ID" value="SAMN04489712_10352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="449"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG05660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="726" mass="76839" checksum="FD3A9C109FA69B7D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XEE0</accession>
    <name>A0A1H5XEE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_103216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10079">
        <property type="protein sequence ID" value="SEG10079"/>
        <property type="gene ID" value="SAMN04489712_103216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289338" evidence="3">
        <location>
            <begin position="29"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG10079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="279" mass="28935" checksum="BDE565DC145EA895" modified="2017-01-18" version="1">MRITRLVTGAACGATALALTAPAAAAWADPGPKAVANVPTTFEPGDDLRVRVTGCGDARPRTGAGLTNEIFAAAPAFRRDGDVWRTVGATRTGLRPGRTYLTEFRCGPPDRRRTFPLEVTVPRRSPSPGEDFEFGFDKVKLSSRTVTPGGEMTFTVTCPTEVSARSASFAEAPEFTEDGEDSFEGTATFKETLPSIVAIKVFCADHGHVTYSTRPDEDDLGDGGPKIPKGAPNTGGGTGGQGPGATPFGGAALALLAAGALGALGARSLRRRAGEQRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XGU0</accession>
    <name>A0A1H5XGU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellobiose ABC transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10929">
        <property type="protein sequence ID" value="SEG10929"/>
        <property type="gene ID" value="SAMN04489712_103246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG10929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="302" mass="32964" checksum="4356531AF828DDAA" modified="2017-01-18" version="1">MTLVAGPDLGGREPRRAARAHRRPGRMRGLWEASPLTYLTLIVALVLSVFPVYWMIIVATRGNDIVGDVPPPMLPGGELGKNLGAVFDAEEASFAKGLVNSAVVATSVTVSTVLFATMAGFAFAKLRFRGKNALLLTVIATMMIPVQMGIIPLYIMMGWFGWQGELQSVILPFLITGFGVFMMRQYTQQAVPDELIEAARVDGCSTFRIYWSVVLPALRPAAGVLALLTFMQTWNDFMWPLAVLSPDNPTVQLSIRQLNSAYFQDYTLVFAGTTVATLPLLIVFVIFSRQIIGGIMEGAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XK45</accession>
    <name>A0A1H5XK45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11717">
        <property type="protein sequence ID" value="SEG11717"/>
        <property type="gene ID" value="SAMN04489712_103278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG11717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="227" mass="24060" checksum="5C45E86F1A7D9A11" modified="2017-01-18" version="1">MSDAAATDTEPARERPVTYDTVEAAVRAQLSKALGGVRGMVEAAVPTIGFTATYVLTHQVRTAVVVGVISAVVLLVVRLVQRSTPQFVINSLLGIAIAAFFALRSGKAEDAFLPGILYNAGYAAAMIFSVLVRWPVVGFIIGSVTGDPTAWRADPGIVKLCSRLTWFLILPCALRVVVQYPLYLAGQVGWLGASKIALGWPLQVAALGAMVWVLARGRTPLQGKPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XP94</accession>
    <name>A0A1H5XP94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine synthase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_103341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13453">
        <property type="protein sequence ID" value="SEG13453"/>
        <property type="gene ID" value="SAMN04489712_103341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023927">
        <property type="entry name" value="SbnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03945">
        <property type="entry name" value="PLP_SbnA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="4">
        <location>
            <begin position="18"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG13453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="323" mass="35100" checksum="EA428138118643BD" modified="2017-01-18" version="1">MLFEAPHDIVLDDIFLKLDGFAHGTDLALKLEGLNPAGSVKLKTAVALIDDAEASGRLLSGGRVIESSSGNLGVALSMLAAARGYRFTCVTDQNAQAAHITAMHRLGAEVVIVTRRDRHHGYLGERIRYIQERLREDPSLVWPNQYANLANRDVHRDTTAAAILREFGRVDFLFAGAGTTGTLMGCAQLFRRRSPGTRIIAVDAAGSVTFGDTPRSRHIPGLGTSRRPEIARPEDMDDVLFIEEPEAVETCREVAVRYGLLVGGSTGSVLAGVRRYAGRFSHDAVVVAISPDLGDRYLDTVYSDAWVDEKYGLDGTRPTRPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y2K0</accession>
    <name>A0A1H5Y2K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17917">
        <property type="protein sequence ID" value="SEG17917"/>
        <property type="gene ID" value="SAMN04489712_103514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG17917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="126" mass="13757" checksum="729F3CAFEDE194DD" modified="2017-01-18" version="1">MPLDTKPVSWRKSSHSSMDENSQCVEVAALPIPPSATWRKSAHSSMDENSMCVEIVTLPIGPSPSEWHKSSRSGGEDHAMCVEVAASGVTVAVRDSKDPDGPYLTFAPDQWRALAERIRQGRLDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YK40</accession>
    <name>A0A1H5YK40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Truncated hemoglobin YjbI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_10460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24481">
        <property type="protein sequence ID" value="SEG24481"/>
        <property type="gene ID" value="SAMN04489712_10460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG24481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="253" mass="28653" checksum="FE3CFFF96E3AF819" modified="2017-01-18" version="1">MIVEYIRYRIDQVDAEEFEAAYGRAAACLAVAPQCVEYELTRCVDEPEWYILRIVWTSADDHLQGFRGGEHFAAFFAEIKLYVRQIEEMRHYKRTAVRGAGGSVPSLYEWAGGAEAFEGLTETFYAKVLADELIGPLFAHMDPGHPKYVAMWLSEVFGGPDRYTRERGGYHHMLIQHLGKAITEPQRRRWVSLLMDAADEVGLPSDPEFRAAFTGYIEWGTRLALANSQPNASPPMQAPVPHWGWGVAPPYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YL68</accession>
    <name>A0A1H5YL68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein E (SpoIIE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24883">
        <property type="protein sequence ID" value="SEG24883"/>
        <property type="gene ID" value="SAMN04489712_10476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="185"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG24883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="414" mass="44904" checksum="19914DE63816A749" modified="2017-01-18" version="1">MAGEEQRSSEIAVDRPAGFGERLLGVLLDRARELPPQLIAPVIAEEIGRIGGRDVSVLLQDYDQLMLTPLPGGKLVAGEPERIDDSPAGRAFLRAVPVEQPLADGVRMFLPLLDGSDQVGVLALTLDSADDDDRRLLRRLASLVGNMLLTKSGYTDLFFRARRRETMSVAAEIQWSLLPPLAMTAPQVAVAGILEPAYDIAGDSFDYALNEGILHLAVIDAMGHGLNAAVLATVAIGAYRHARRTDVGLAELYAFMDTAIDEQFGPDQFVTAQMSRLDTATGHLEWVNAGHPAPLLIRDRRVARRLEGPGTLPVGFGGDQPQTNELGLRPGDRLLFFTDGLVEEHRPGGEEFGEERLIHVIEGTGRDGENVRETVRALSHTLMRERRGITTDDATLLLVEWRGGGADHLTAPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YMB3</accession>
    <name>A0A1H5YMB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG24637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG24637">
        <property type="protein sequence ID" value="SEG24637"/>
        <property type="gene ID" value="SAMN04489712_10466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG24637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="161" mass="17190" checksum="EEB61DA3C2B92CE0" modified="2017-01-18" version="1">MAHDINDCTIDPGPVRPYPRGARLSLAAGAAHRGALDGGWWPRSRDARAELPELAATLVEHLGRVTHLAVDPYRWERIPADITIAGRRVKVGRFPGLGHMVAVIRGRMDTFLLLVVPPEAARACAQAALSESATGTASERPDRILAACDISTAPATTATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YNA7</accession>
    <name>A0A1H5YNA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25643">
        <property type="protein sequence ID" value="SEG25643"/>
        <property type="gene ID" value="SAMN04489712_104102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG25643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="272" mass="30826" checksum="3FF584BA308C653B" modified="2017-01-18" version="1">MTLRHRTLQRADCEIHYWIGGPDDGPPIVFTHGATLDHRTWEPQIEAFTARYRILLWDVRGHGRSIPNRVPWTLREAADDLLAILDREDIERTVLVGQSMGGNLSQEIVYHHPGRASGLVALGCAGNTLPLSRRERLQARAVVRMLPWYPRKTLIRQEARASARDPQVREYVREAASRMAHRDMVAVMASLVGALHPEPGYRIEIPELLLHGEHDRLGNFRTAMPVWERRDPLARHLVVPDAAHLANQDNPDFFNDAVLSFLAEHGLDSPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YQ72</accession>
    <name>A0A1H5YQ72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tight adherence protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26243">
        <property type="protein sequence ID" value="SEG26243"/>
        <property type="gene ID" value="SAMN04489712_104126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG26243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="296" mass="32008" checksum="AB417ED133B2E118" modified="2017-01-18" version="1">MTALAVVAGLLTACGILIVVRELWPGPPRLEAALARIQATPLPSAPSRPAGGWEDLGRWLADHLARPAGMLAVPRGDLALLDRAVERFMLDKLALFLTGLVMPSVFFGLVALVGGAVSWTLPVLASLALGVGLSFVPDWNVRSEARRRRRDFRYAFTSYLQLVVLERESGAALNSALEDPAKVADGWPFQRVHQALTRARHAQQQPWRALARLGEDIDVRDLIDLAHTAEIAGGEGAKMHDVLVAKIASMRHEASAAARSEANSRTTAMWVPTSLLMLGFVILVGFPFFSRLLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YXS4</accession>
    <name>A0A1H5YXS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28642">
        <property type="protein sequence ID" value="SEG28642"/>
        <property type="gene ID" value="SAMN04489712_104231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG28642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="286" mass="30621" checksum="9C8C3E863911D2E4" modified="2017-01-18" version="1">MRFAYGTNGFANHRLDDALAVLADLGYDGVALTLDSGHLDPYDGDLAQQVGKVAARLAELGLGVVVETGGRYVIDPRRKHHPTLLSAPEDAARRIDLLLRAVRVAADLGAEAMSFWSGTAEPDVSPELAWQRLTAGVAEVVAEADRYGVRLGFEPEPGMFVDTIAGFEELHARLGAPAALGMTLDIGHCRCLEPQPVPDCVRRAAPHLVNVQIEDMRRGVHEHLEFGRGEIDFPPVLAALAESGYRGLVGVELPRHSHAAPAVAEHSIGFLRAAAAEAGITKEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z7M4</accession>
    <name>A0A1H5Z7M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG32040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG32040">
        <property type="protein sequence ID" value="SEG32040"/>
        <property type="gene ID" value="SAMN04489712_104390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01782">
        <property type="entry name" value="MCEVIRFACTOR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="40"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="141"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG32040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="361" mass="39483" checksum="7ECC2F6FE7F63F39" modified="2017-01-18" version="1">MRVPFRERNPVPIGLISFGIIAVLMVLAANLGNLPLLGGGPTYSAQFSEAAGLRSGEEVRVAGVRVGKVTGLDLAGDHVKVTFRIEEDGVRLGDLTRAEIKIKTMLGAHYLALVPRGTGRLNREIPLSRTSVPYNVVPAINDLSRQVDQIDHREVARSFQTLADTFENSPEEIRASLRGLRRLSETISSRDTELHELADRARSVSQLLADRNADFARLVDDGDRILQAVQARREVIHQLLVRTVLLSQQVNALISENEAQLRPMLDNLKRVNDVLLRNQRSLDRMLELYGPFTRQFADATGSGRWFDNYIQNLLPIPASIKNAPSGNGGAGGTGDAGGRPGTGQPSSTPRPSKDNPLPFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZCE8</accession>
    <name>A0A1H5ZCE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34068">
        <property type="protein sequence ID" value="SEG34068"/>
        <property type="gene ID" value="SAMN04489712_104482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="684" mass="73499" checksum="8D7E3F4EC50DDA8B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZDU0</accession>
    <name>A0A1H5ZDU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease, Uma2 family (Restriction endonuclease fold)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34224">
        <property type="protein sequence ID" value="SEG34224"/>
        <property type="gene ID" value="SAMN04489712_104489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="192" mass="21628" checksum="1658298403135531" modified="2017-01-18" version="1">MGMPAVAEDYMSIWNHPGEWTEEDYLALPRGAAKIELIDGRLLVSPMPSRLHQKYMQRLAVHLDAQSPDALDVVIEVNLRVGTDKILIPDLLATYEPGDTYVHDAKHVLLVGEIVSPSNRGEEWMQKSRFYARAEIPWYLLVERDAEGGPTLILGRREGECYVEHARATPGQELVFPEPLGTMDPAVLLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZEL3</accession>
    <name>A0A1H5ZEL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_104512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34711">
        <property type="protein sequence ID" value="SEG34711"/>
        <property type="gene ID" value="SAMN04489712_104512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="301"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG34711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="754" mass="83474" checksum="57AD38A4E03306F4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZWQ0</accession>
    <name>A0A1H5ZWQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PucR C-terminal helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40590">
        <property type="protein sequence ID" value="SEG40590"/>
        <property type="gene ID" value="SAMN04489712_10541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="205"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="369"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG40590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="459" mass="49136" checksum="400589968EC2150B" modified="2017-01-18" version="1">MSGGFSTETLTGADTVRAERSRILSDLLHHVDDLAATALAAMRAEIPAYRDRDAGFLADARDQIARHYRTKLAVLLEERTVTLDDIAFTRRAAMRRARAGLALADYINAFRVGQQVFWEAVVERAGRTFAGHEAALTLAAPLMRYCDFASTQAANAYMEFQQYAAAEAVRESRDLLETLLDGEAPTRGPQLAAAGAHGLTPGTRTPLVVVVAVLVGPADRTAVATGPDQGADARHAACAAIARTGVNGLRTLSVVRRSEIVAVPALGPGGDAGRLCDRLQAVREGLLGEGIALAMGISTVACGIGQVPQAYREARAALEFLPEDGGVAALPRLTPFQYLAMRADDTARHLVDPRIAALLAEDRERGGVLTATIRAFAAADLNLRASAERLQIHHNTAQYRLRRIQERTGRNLRHITDLVELLVAIALQDSRPRATNPGRKRLVSATNEDGRSADVPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A511</accession>
    <name>A0A1H6A511_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43819">
        <property type="protein sequence ID" value="SEG43819"/>
        <property type="gene ID" value="SAMN04489712_105218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="87"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG43819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="168" mass="17939" checksum="0C85425B6F7F8CDF" modified="2017-01-18" version="1">MPPPQHGGRPLTPPPHGREATLLPPDEAGHRGSPDSTAFMCPHCEAVLSNPAAAQCDNCLRPLRQQAPVLRVVFPSGELKISVGQHLVLGRDAGQSPVASTFTQYDNVSRRHSTVWLDPSGTAWVRDEGSTNGTFVNGERLPRGVEAPLRDGDQLRLAADVTGTVQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADL3</accession>
    <name>A0A1H6ADL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46808">
        <property type="protein sequence ID" value="SEG46808"/>
        <property type="gene ID" value="SAMN04489712_105384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="134"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="42660" checksum="69C93D2D7B80C78A" modified="2017-01-18" version="1">MTATAWVETVAALWPGARVEPSGARDGGPARREFVFLPDADRPRLLLPAGLPGAAAAALRRYSHDLGPAQRISRSLTATAVRTGLPERALRDRLRVVGGDGESVEERLGGLLGRQVVVSVGLGTVRANRKPILHVLTPAGEPVAFVKVGDNPTARGLIAAEAAALERLAGLSPPGLSVPRVLHHGDWQGLGLLVLSPLPTSALGWRPRRNPPVAAMRALAGAAGIERAALEDSPYWTGMRQVPARLADTAVAERLAGVIERIGARHGARKLDFGAWHGDWTPWNMAWHRGVLQLWDWERFAVGVPFGFDLLHYRLQEAARLSARSPYEAWPDGAPALLEPLGASVSGGAGRATVELYYLELCARYLLAAQEPIGDPLREQSRRLLDLLHDHAGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AHG3</accession>
    <name>A0A1H6AHG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dolichyl-phosphate-mannose-protein mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SAMN04489712_105421</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47445">
        <property type="protein sequence ID" value="SEG47445"/>
        <property type="gene ID" value="SAMN04489712_105421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="92"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG47445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="516" mass="57536" checksum="A26EB1C521876A99" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AK51</accession>
    <name>A0A1H6AK51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48447">
        <property type="protein sequence ID" value="SEG48447"/>
        <property type="gene ID" value="SAMN04489712_105476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292772" evidence="1">
        <location>
            <begin position="29"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG48447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="649" mass="70362" checksum="EF37052FD3C76E87" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AUH5</accession>
    <name>A0A1H6AUH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52319">
        <property type="protein sequence ID" value="SEG52319"/>
        <property type="gene ID" value="SAMN04489712_10622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="18471" checksum="CF12E4701EA25349" modified="2017-01-18" version="1">MDVPREPRWLSEEEMTAWLALASVLIRLPAALDGQLQRDAGISHFEYQVLAGLSMSPERTMRMSELAQLADGSLSRLSHVVSRLEKRGWVRRTPDPANGRYTLAVLTDDGWEKVVATAPGHVEAVRTLVLEPLTRTQIRQLSEIGSRIARAVDPDGDCPTTRFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AVN2</accession>
    <name>A0A1H6AVN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52344">
        <property type="protein sequence ID" value="SEG52344"/>
        <property type="gene ID" value="SAMN04489712_10624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9521" checksum="6F15D50981B58140" modified="2017-01-18" version="1">MIDADLSWISWRKSSRSMRRDNCAEVGMWCKSGHSAGNSGECVEVAPGNAMVPARDSKDPDGPVLGFEMDERHAFVFAIKAGQLDPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWM2</accession>
    <name>A0A1H6AWM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52467">
        <property type="protein sequence ID" value="SEG52467"/>
        <property type="gene ID" value="SAMN04489712_10633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="16365" checksum="5B6CFE00B1409518" modified="2017-01-18" version="1">MQGDPPPQLRDMADFACLPSAARWARKHTVGVLHRWQLCHFADTAELLVSELVTNAYRASGVDVERNGYAALARVPCISMRVASDRRSLLIEVWDANPEPPVLKEADVHAEGGRGLLLVDSLAERWNFYFPLAGGKVVWCEIAGRDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZ57</accession>
    <name>A0A1H6AZ57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53682">
        <property type="protein sequence ID" value="SEG53682"/>
        <property type="gene ID" value="SAMN04489712_106109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="229" mass="24851" checksum="C4EDF493A487BA42" modified="2017-01-18" version="1">MTTSAAGESTERSPSTRFMVWFFFVSLGALVLTVWLLSLGAKGSEISGVLSLLVALVSPFIPVFIDRLSREQGGPGLPLPSRKWLMFVTAALLGMTLSLVYWFAYHKPDLNVTDRVVLGKAAGLRDGSTATVRIRPPLGRSHLYLVFGLTNRSEVGDCVDPATLRGTLTVDGVDRGEIDARAGQELRYPLGKAENSVDLTVTLSEEKGDRTCSVDLRVTEAVLYNEGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2J5</accession>
    <name>A0A1H6B2J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54822">
        <property type="protein sequence ID" value="SEG54822"/>
        <property type="gene ID" value="SAMN04489712_106182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293260" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG54822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="43" mass="3954" checksum="34338E56B14E9B91" modified="2017-01-18" version="1">MQVVCYAVATAGFSVATPGLTAANADVVSADAARALGGTAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B396</accession>
    <name>A0A1H6B396_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54845">
        <property type="protein sequence ID" value="SEG54845"/>
        <property type="gene ID" value="SAMN04489712_106184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="284"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG54845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="544" mass="56494" checksum="C81677AF6F1651A8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B4G8</accession>
    <name>A0A1H6B4G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-8X methylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_106254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55733">
        <property type="protein sequence ID" value="SEG55733"/>
        <property type="gene ID" value="SAMN04489712_106254"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="6">
        <location>
            <begin position="26"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG55733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="21951" checksum="BA409866CFFC8C92" modified="2017-01-18" version="1">MSEHVTKAAPGRPGGERPSARRPHPIEVRSYEILRSRVDLSPMPPLWRAVAERVIHASADLEYAVDLVTDEDHLARGLAALRAGAPVVTDVGMVAAGITARPTLCHIGDPAAARMAKAAGITRSAAAVRLSYSEVGPGAVWVVGCAPTALEEIIKLDVRPALVIGLPVGFVGAAESKQALRASGLPQVSNVSEKGGSAVAAAAVNALLYYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BHI5</accession>
    <name>A0A1H6BHI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monoamine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59855">
        <property type="protein sequence ID" value="SEG59855"/>
        <property type="gene ID" value="SAMN04489712_10794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293859" evidence="1">
        <location>
            <begin position="44"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG59855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="535" mass="57585" checksum="86776D8F540C8A72" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BI78</accession>
    <name>A0A1H6BI78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40-like Beta Propeller Repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG60095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG60095">
        <property type="protein sequence ID" value="SEG60095"/>
        <property type="gene ID" value="SAMN04489712_107109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG60095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="35383" checksum="EA92CDE96EEFF0B6" modified="2017-01-18" version="1">MAVAASLVLTGIAVAYTVRAADERRPTPGKATGAAFDLTAGRLVFRDMRPGRGRDAVAAVPLARTRDGRTSADLRCVRFYAAAGTGVCLNTAPGPVPRTYAAVLDRNLREVRRVALPGVPSRARVSASGRMISWTVFVQGDSYSDGSFSTRTGVLDTRTGRTVTSLEGIALTLDGRRHRSPDVNFWGVTFAADDDLFYATVSTGGRTYLVEGSFTRWTARTLRENAECPSLSPDGRRLVFKKRVSRDPADPWRLYALDLRTLRETPLAEPHSVDDQAAWLDARTVMYARPRESGGSDVWAVPADGSGPPRLLVPDAASPSALGRAKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BRC8</accession>
    <name>A0A1H6BRC8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">SAMN04489712_107321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62776">
        <property type="protein sequence ID" value="SEG62776"/>
        <property type="gene ID" value="SAMN04489712_107321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="210"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG62776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="344" mass="36948" checksum="00AAD74994FF18DD" modified="2017-01-18" version="1">MGNKLSFLGRDMAVDLGTANTLVYVRGRGIVLNEPSVVAINTNTGKIHAVGIEAKRMIGRTPGNIVAVRPLKDGVIADFDVTERMLRYFIQKVHKRRHFAKPRIVVAVPSGITGVEQRAVKEAGYQAGARRVYIIEEPMAAAIGAGLPVYEPTGNMVVDIGGGTTEVAIISLGGIVTSQSVRVGGDELDQAVIAFSKKEYSLMLGERTAEEIKMAIGSAYPSADEEPHAEIRGRDLVSGLPKTVVISAEEVRRAIEEQVNAIVDAVKTTLDKCPPELSGDIMDRGIALTGGGALLKNLDERLREETGMPIHLVDNPLDSVVLGTGKCVEDFEALREVLVPEPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BX22</accession>
    <name>A0A1H6BX22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase RsbT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65005">
        <property type="protein sequence ID" value="SEG65005"/>
        <property type="gene ID" value="SAMN04489712_10870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG65005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="134" mass="14260" checksum="49F5998C31E19C15" modified="2017-01-18" version="1">MSDVHEVRVGSSDDIVGIRKMVRTIAGDIRMSLVDQTKLVTAASELARNIVVHGGGGTVRIERLTGPTGRTGVRMIFSDEGPGISDVDLALTDGWSSGQGLGLGLPGSRRLVDEFELDTAVGRGTRITVTKWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXF1</accession>
    <name>A0A1H6BXF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65369">
        <property type="protein sequence ID" value="SEG65369"/>
        <property type="gene ID" value="SAMN04489712_10899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG65369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="23417" checksum="1B8ECEE522D004C7" modified="2017-01-18" version="1">MIRVLVADDQAAVRAGLVLILRSAPDIEVVGEAADGLEAVALARRLRPHVVLMDVRMPRLDGISATRELAGVDADVLVLTTFDVDEYVFGALRAGAAGFLLKDIDADRLVEAVRTVAAGEGVLAPAVTRRLISAFAGRPRPVGAAPPPGLADLTPREREVFGCLGEGLSNGQIAARLHMAETTTKTHVSRILAKLGLRSRVQAAILAQETAESGLPAGGPDAGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1K0</accession>
    <name>A0A1H6C1K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_108205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66577">
        <property type="protein sequence ID" value="SEG66577"/>
        <property type="gene ID" value="SAMN04489712_108205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294326" evidence="7">
        <location>
            <begin position="19"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="18"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="290"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="483"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="735"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG66577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="833" mass="86723" checksum="21069AD65BD25DB3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C3I6</accession>
    <name>A0A1H6C3I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative mycofactocin binding protein MftB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67205">
        <property type="protein sequence ID" value="SEG67205"/>
        <property type="gene ID" value="SAMN04489712_108263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023850">
        <property type="entry name" value="MftB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03967">
        <property type="entry name" value="mycofact_MftB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG67205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="108" mass="11386" checksum="D7F3B9506F512EA1" modified="2017-01-18" version="1">MPEPSPPGAGAQSAGFDLDAAWELHPQVAVRPEPFGALLYHFGTRRLSFLKDRTLLTGVRALADQPSARAALRSAGVEEDDLGRYQAALATLADSAMLVRRAAAAGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7K6</accession>
    <name>A0A1H6C7K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68902">
        <property type="protein sequence ID" value="SEG68902"/>
        <property type="gene ID" value="SAMN04489712_10930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG68902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="157" mass="16015" checksum="CCAB8B79584AA52E" modified="2017-01-18" version="1">MSTGMCAGIGRGALAGAAGTTALNTVTYLDMVWRGRPSSSAPERSAERLSEISGLPVPGDERTRENRLTGLGALLGIAAGVGIGMAAGALRSAGVRMPSWLEPIAIGALAMAAMDTSMAAVGVTDPRNWSGKDWASDVIPHLAYGVVTYRTLEATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAA7</accession>
    <name>A0A1H6CAA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69929">
        <property type="protein sequence ID" value="SEG69929"/>
        <property type="gene ID" value="SAMN04489712_109127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010840">
        <property type="entry name" value="YqiJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07290">
        <property type="entry name" value="DUF1449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG69929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="217" mass="22982" checksum="122229CBC6E987F0" modified="2017-01-18" version="1">MGEFVGTVFAFPTVLFTFSLLVVVGYWAFVVLGAADLDLLDGDAEAGAAGLGGFLGALRLGEVPVTVALSLLIAFSWFFSLVGAVVLDRFDLSSPLTLALGLLALTLAVVAGWLVTCLVVMPLRKALPQVRESSRHDFVGRMCVIRTSTVGPDFGQAEITSPDGSSAIIQVRQETPDPLAEPLTVGSSALIFDYDTAGEFFRVMPYDAALDPDRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCE7</accession>
    <name>A0A1H6CCE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_109176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70513">
        <property type="protein sequence ID" value="SEG70513"/>
        <property type="gene ID" value="SAMN04489712_109176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG70513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="23038" checksum="6D77869EE256A877" modified="2017-01-18" version="1">MRVVLAEDLALLREGLVRLLEATGFEIAAAVDNGPDLLRALVDHRPDVAVVDVRLPPSFTDEGLQAALAARREVPGLPVLVLSQYVEQLYARELLADGSGGVGYLLKDRVFDSEQFVDAVRRVAAGGTAMDPEVVSKLMTRGGQPLSRLTPRELETLELMAQGRSNAAIAQQMVVTERAVAKHIANIFTKLDLAVSDDDNRRVLAVLAYLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CKS4</accession>
    <name>A0A1H6CKS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73599">
        <property type="protein sequence ID" value="SEG73599"/>
        <property type="gene ID" value="SAMN04489712_110130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="109" mass="11754" checksum="D196B582881F0965" modified="2017-01-18" version="1">MRYLMTNKAAETAPAPDERLHAEMGKFIEELTAAGVLLATGGLEPGGIRVASHGDEITVTDGPYAEAKEAVAGFALIEVRSQEEMLELARRFRKIVGDGECEIHQVFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CM43</accession>
    <name>A0A1H6CM43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74041">
        <property type="protein sequence ID" value="SEG74041"/>
        <property type="gene ID" value="SAMN04489712_110183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295079" evidence="2">
        <location>
            <begin position="30"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG74041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="423" mass="44028" checksum="0E179AE6B5CE786A" modified="2017-01-18" version="1">MGLRRLLTCVVAGTTMAAAGLVAAPSATAAPLLCLSTDEGIYTSPGTITGKPGDLISCRPTALPQIPGGVRMKAWKIKYVSTDVKGAKIAVSGFVAIPDAAWTGGGSRPTVAFTPGTLGSGSQCALSKQMAGEQVDSYEARNLQKFLEAGYAVAASDGVGYMNGQVHTYTVGLNAGHAVLDAVRASRQIPGGSLRSDSKVGITGYSEGGFNSLWAAQLASSYAPELNVVGAAAGGVPGDLKLVAERLNGSAFAGFLADAVVGLSAAHPEMPFNELLNDRGRQAVEDVRSNCLFGTLGAFAFQKLENFSTDRLTLAQIYALRGSNGVSWGEVIDAQKVGVGIGTGSSGARYRIGFPVYQYRGALEEIIPHEAEDGTRERYCQAGITTQWRTYAGEHLTTDWLAAGDVTDWLGDRFTGKPATGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMJ1</accession>
    <name>A0A1H6CMJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_110160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73835">
        <property type="protein sequence ID" value="SEG73835"/>
        <property type="gene ID" value="SAMN04489712_110160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG73835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="34863" checksum="DD582D938373AE2F" modified="2017-01-18" version="1">MTLPTPAPAPATSASPSARLGIGLDVGGTKIAGGVVTENGEIVHRLRVSTPPGADADTTVEVLRDLVDRLRDRHPEVAAVGAGAPGMVRWPEGHIEYAPNNAYRGLALRRRLAEATGLPTVVDNDANAAAWAETCFGKGKGRDNVIVLTVGTGIGGGLVLGGALYRGQTGLGGEVGHIIVNPVDGHECGCGAVGCLEAEASGTALRRMGRQAAEREPDGPIATLAAGTELTGEIVHQAARQGDPTAVDLFDRLGTWLGVGIASLVNVFEPELVIIGGGLVQTGDLLLGPARTAYGRYAFARDLRPLPPITTAALGNEAGIVGTAALALAAAHDAGHDAGLERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMU9</accession>
    <name>A0A1H6CMU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74379">
        <property type="protein sequence ID" value="SEG74379"/>
        <property type="gene ID" value="SAMN04489712_110220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="153"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG74379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="28972" checksum="9FF945D9721E700F" modified="2017-01-18" version="1">MTRTTTDRITWADLPRVVRDQVRERTGRVTGSRPAGGDRSDITATLDTATGPVFIKGAHGGVFARSLNNEARVSPHVAGIAPGLLWRFEVDGWTVLGFEYIEGRHADYSPGSADLGLLHTAVSHLQTIPVPEVVTRGAERHYGGLDVLTGGNLLHTDLHPENVLITPRRAYIVDWAWACKGAAWAEPAMLAFRLMAAGHTVESAEAWGRSFPSWTDGRPLAAFVAANARVWERAAQQDPQEWKIRAAALARQWADYHRPEAGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT61</accession>
    <name>A0A1H6CT61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron complex transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_111118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76068">
        <property type="protein sequence ID" value="SEG76068"/>
        <property type="gene ID" value="SAMN04489712_111118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295169" evidence="1">
        <location>
            <begin position="36"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="58"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG76068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="327" mass="34699" checksum="14F64F1032B513B2" modified="2017-01-18" version="1">MMGRRPLSLLLALASVLFVAACGGSSGGAGAGAPAAEGFPVTVTNCGVRTTYQRPPQRAVTLNQHATEIVLALGLERSMVGTGYLDDEVLPELRAAYDQVKVLSKEYPSYEALLSAEPDFVYGGWSSAFAEKEGRSRAALRKAGIATHLNIEECPSGPVTMATVEEEIRTIAKIFGVPERAERRIASLRTVLDGVEGALAGVAPVKAAVYDSGDKTVFTAGGAGIGNEMIRLAGGTNLFSDVQKAYGDVSFEQLAERAPEVIVIYDYGERSAEDKKRFLLANPALKDVPAIRNERFAVLPLSSTVTGIRVAGAVESLARQLHPDRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CV79</accession>
    <name>A0A1H6CV79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG76892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG76892">
        <property type="protein sequence ID" value="SEG76892"/>
        <property type="gene ID" value="SAMN04489712_111221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG76892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="116" mass="13192" checksum="4B4996DAD6EA0F6A" modified="2017-01-18" version="1">MAQDDPLSVTFAALADPTRRAILARLAEGEATVGELAEPFDVSLPAISKHLKVLQRAGLVEQGRQAQWRPCRLRPQPLQEVAAWMAQYREFIGQSYDRLDDYLQELQQDREKEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CVN5</accession>
    <name>A0A1H6CVN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77091">
        <property type="protein sequence ID" value="SEG77091"/>
        <property type="gene ID" value="SAMN04489712_111247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG77091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="34113" checksum="695E9DA9DACFD907" modified="2017-01-18" version="1">MTGCAPVAETARRLCDRALSWLHAHRELDTLPSTSDLGDPDSVYKPLGETTLAASLVVRDGTAGPGRRAAARSLLDFTWAQMRGGDLLYERLLQHTLLTDPAETYAHFVRAGYRHPRLDELLAHQVRLRSVRAVELIPDRKLAVANAHRIIGLDDDADWDALIRATWLGGLPEPWAIDWMTAYQMTHTVFHSTDWGALPYRLPADLTAYLHDWLPVWIDIWREIRQWDLVAELLVVGACLEEPYCDPDDWRALAEIQHEDGFVPRDGDPIDENPVQRFKDHQHTVVVTAVAGTIAAARASAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYS2</accession>
    <name>A0A1H6CYS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78172">
        <property type="protein sequence ID" value="SEG78172"/>
        <property type="gene ID" value="SAMN04489712_11240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="164" mass="17299" checksum="27B6172967AB60BA" modified="2017-01-18" version="1">MGLQLPGELASLLGMLGYTWPEADEEKLFQMGRDWLDFAADFGGAAQDADGHAGQVWAMNEGEAIKAFQQAWNEPDSPVPALQDGQVAANIMGAGLMVCGMIVLTLKIAVIIQLIQLAIQIAMAIAQAVPTFGASLVQIPIFKMITGLLIDMAISMALEAILGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CZY7</accession>
    <name>A0A1H6CZY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_11265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78344">
        <property type="protein sequence ID" value="SEG78344"/>
        <property type="gene ID" value="SAMN04489712_11265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG78344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28276" checksum="2C6780376027E597" modified="2017-01-18" version="1">MTPAHGGHGHGSPLLAVLLPLVAVAVAAAGYVLLAVRDRDWSGRRTVSFLAGCAVLAVGLTPGLSPWAEGDFRGHMLQHLLIGMVAPLGLVLAAPITLVLRSVPPRTGRLIGRALRSRPARVITHPVTALTLNVGSLGVLYFTPLYGVLGTHPLLHLHFLAAGYLFAWVITGPDPAPHRPSVPVRLVVLGVAVTVHAVLSQLMYAGLFVQVPAPADQLRGAGELMYYGGDIAEMLLALSLLATWRPRPARARPATGPRWRLSPRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0F3</accession>
    <name>A0A1H6D0F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78066">
        <property type="protein sequence ID" value="SEG78066"/>
        <property type="gene ID" value="SAMN04489712_11222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG78066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="72" mass="7747" checksum="880DD23DE52B158C" modified="2017-01-18" version="1">MRGTVYAVCDSGSAQQLRHSRLTHLAEDGWSAPTLMALSGHENIRSLAIYTDVSAEAVGTALAEQGPARRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1N6</accession>
    <name>A0A1H6D1N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78705">
        <property type="protein sequence ID" value="SEG78705"/>
        <property type="gene ID" value="SAMN04489712_112114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="424"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG78705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="526" mass="57865" checksum="8EAA1A240B3208BC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D1Y9</accession>
    <name>A0A1H6D1Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_112142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78923">
        <property type="protein sequence ID" value="SEG78923"/>
        <property type="gene ID" value="SAMN04489712_112142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG78923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="219" mass="23186" checksum="D2A19FC2DA6405C7" modified="2017-01-18" version="1">MIRTLIADDATLMRAGIRLILEHADDIEVVAEAADGPAAVRACREQEIDVALLDVHMPGGDGLTAIAGIARESPRTNIAMLTAYDDDRNVAEALRAGAIGFLLKDTAPTELIRAVRVAATGESILAPQITRRLIERHLISGSGGAEAAARSRIERLTDTERDVLRLVSAGLSNAEIAERLYMAAGTVKAHISRILTKLDCANRVQAAILAHDAGLPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2A2</accession>
    <name>A0A1H6D2A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79407">
        <property type="protein sequence ID" value="SEG79407"/>
        <property type="gene ID" value="SAMN04489712_112211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="25415" checksum="46E1555748E8644D" modified="2017-01-18" version="1">MTGTGPNAASADVHVDPDSGLKPEIRKNPDGSLDVVVPKGPGHPEDVRIHVDPGKHVRIDLDKNPDGTLKVKVGKAPPHPEGPAPGADPAKLPGGQSSPEMPKPPGGGPPGGGGMPPGGGGGMPSGGGGPSGGGGPSGGGGPSGGGMPRMPQGPPGPGGPGGGDRQVDSTAVRKLGDDIDIQAGGKMDAAKRRMDNTEVSWPAFGVLGFPLNMAHGQVKGSASQYLADGRSTLTDWKRSLHRNADTWKGAEDANTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D3J4</accession>
    <name>A0A1H6D3J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_112238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79568">
        <property type="protein sequence ID" value="SEG79568"/>
        <property type="gene ID" value="SAMN04489712_112238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG79568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="278" mass="28866" checksum="31DC197F9A6C1B7D" modified="2017-01-18" version="1">MAAPQSRPQAAVLEGRPRTSGPQSRPRAAVLEDRSEKMVPKGHPQTAVAEGRSRVAGRRGRLGTAAPQGRLRAAHGPSTAGRAEGRRPVRARERSAVPTPVAAAQPGPPVRTGAEAAARRGPRTPPAAGRPGAGAAARDPPAADRPGLVDPARAHRDPPPRAPTAAGRRASGGRRCRPPYRLRPPCSPQSPLVAARARRAPPHTGEVGIVSGIAGRNGMAQLSRAGRPARPPGRPPARPGGAPCGPPATCRRPPSRRRRRPPARRASSRRGRTARSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4J9</accession>
    <name>A0A1H6D4J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-lactate dehydrogenase complex protein LldG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80279">
        <property type="protein sequence ID" value="SEG80279"/>
        <property type="gene ID" value="SAMN04489712_11354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="111"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="208" mass="22061" checksum="D61148960DBBBD08" modified="2017-01-18" version="1">MSSAREEILGRVGRILGPGRTPAATAYTAIERPYLRRHHEDGVLDLFAERTADYRATVHRVDPADLPGAVARALTGSRYAVPGGLPAEWLAEVDPARLAHDPGIGELDGLDGVVTGCAVAIAETGTIVLDHGPGQGRRALTLVPDYHLIVVTADQVAPDVPEALERLDPARPLTFISGPSATSDIELNRVEGVHGPRTLEVILTVRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D560</accession>
    <name>A0A1H6D560_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho termination factor, N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80118">
        <property type="protein sequence ID" value="SEG80118"/>
        <property type="gene ID" value="SAMN04489712_11317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009317">
        <property type="entry name" value="ChaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037205">
        <property type="entry name" value="ChaB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06150">
        <property type="entry name" value="ChaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140376">
        <property type="entry name" value="SSF140376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho_N" evidence="2">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="133" mass="14969" checksum="55423932D758FF77" modified="2017-01-18" version="1">MPGREELPSTLRRSPEKAQRTWIKAHDSAVEEYGEGRRAHQTAFAALKHAFEKVGDRWQPKGRKGPSDKRAATPRPQSRKQPSAEGVDANASKQHLYEVAKSLGVQGRSTMSKDELVQAIKKENRRRTAKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D6Z5</accession>
    <name>A0A1H6D6Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylglucosaminyl deacetylase, LmbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80844">
        <property type="protein sequence ID" value="SEG80844"/>
        <property type="gene ID" value="SAMN04489712_113162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="29877" checksum="0AE5CD61EF213B9B" modified="2017-01-18" version="1">MDRELTLMAVHAHPDDEVLGTGGAFARYREEGLRTVLVTCTNGEQGDGPGGVKPGDPGHDERDVSRRRLAELRESAAHLGIGHVELLGYRDSGMDGWDANHASDAFTNIPVQDAARRLAVLMERYRPQVVVTYDENGGYGHPDHIQAHRITLAAAELSGIPDKLYYTAVSRARIAQMFAYAKEQGLDLGDEELPDDFGTPDELITTSLDVSAYADRKRKALQAHASQGDSIFLLNMPEEIQLRAFGEEHFVRRLSRVDAPAQEDDLFAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DA78</accession>
    <name>A0A1H6DA78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81723">
        <property type="protein sequence ID" value="SEG81723"/>
        <property type="gene ID" value="SAMN04489712_114128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="15967" checksum="1CCAD27A4AA417F8" modified="2017-01-18" version="1">MDDILLALAAAAGTSVVEAAGTSSWQAFQQALVRWFGRGNAVAEQHTRARLERTAAALTSGADDVAEARIGERAAWRALVEATLEGMEPQERQTAVAELRQLLNLHAHGGGASAGPEGIAVGGDIKVNAHDQAVAAVKIGTVSTGNPQPPDANRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCV5</accession>
    <name>A0A1H6DCV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaA</name>
        <name evidence="15" type="ORF">SAMN04489712_115153</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83130">
        <property type="protein sequence ID" value="SEG83130"/>
        <property type="gene ID" value="SAMN04489712_115153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="13">
        <location>
            <begin position="439"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="14">
        <location>
            <begin position="651"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="232"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="447"/>
            <end position="454"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEG83130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="748" mass="81703" checksum="D7731916C24390F4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DDZ7</accession>
    <name>A0A1H6DDZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82766">
        <property type="protein sequence ID" value="SEG82766"/>
        <property type="gene ID" value="SAMN04489712_11581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG82766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="56" mass="6084" checksum="A3C2BF265071ED65" modified="2017-01-18" version="1">MIYDTMSGLLFLGGDTPEAAAKVIAKVAIPGGGGRSAMTIKGWPRRPRNRLFTWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEQ4</accession>
    <name>A0A1H6DEQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_11666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83779">
        <property type="protein sequence ID" value="SEG83779"/>
        <property type="gene ID" value="SAMN04489712_11666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG83779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="378" mass="42811" checksum="6A79AAE5EB21EF69" modified="2017-01-18" version="1">MGAAATKLRDELRRLVAEHVPPDYLGAFTDDPADLETAQKFCRLLAERGLLCLAWPREYGGRDASPWEQTVVREEMWAHHEPRGAQYMGVNWVGPTIMRHGTDGQRRRHLPPIARGEVIWCQGFSEPDAGSDLASLRTVARRDGDGWLISGQKVWTSYATMAQWCFLLARTSRRERRQQGLTIFLVPMDAPGVEVRPIDCLMGPHHLNEVFFDDVRVTEADVLGTVDEGWKVVQEVLSFERVGIARYARCERLLQAAPRVLGDGWEDLPAELRVRWARMLTHCRRARLLAYRVIALQSRGQVRPNDAAAYRIAVTRLDQDSAEVLMDIAALAPQDDAQTRWFRLEVEDHWRYSHASTVASGSIDVQRILLARALLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIN2</accession>
    <name>A0A1H6DIN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_117143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85128">
        <property type="protein sequence ID" value="SEG85128"/>
        <property type="gene ID" value="SAMN04489712_117143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG85128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="239" mass="24977" checksum="F11B6235D1D09698" modified="2017-01-18" version="1">MVDLELDQGLAVITINRPQARNAIAPATMDELDRALDKAARARALVITGAGDRAFVSGGDLKELAKIRTEDEALAMALRMRGVCDRLAAFPGPVIAALNGHALGGGAEVAVAADIRVAADDIRIGFNQTALAIMPAWGGAERLAALVGRGRALMLAGSGTVLEAAEAQRVGLVDQVLPRTCFAAGWRALARSLATVPAGEIKRVVSGGLTAEEAARAFARLWVADEHWAAAERVMNRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLT0</accession>
    <name>A0A1H6DLT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86222">
        <property type="protein sequence ID" value="SEG86222"/>
        <property type="gene ID" value="SAMN04489712_11925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="28335" checksum="4AF0206B64F1FE55" modified="2017-01-18" version="1">MKQESSPGDEVRLTFEGSVATITINRPAVRNAMNRDAWTVLVDHLGAVTRSEARVLVLTGTDGHFCAGADTSAQRRTDLHPLDRLSHVTAALVALQELPLPVVAKVDGPAVGAGLSLALSADLVVATTRSRFGTAFSRRGLSLDTGSSWLLPRIVGLQTAKRLAYLAETLDAEKAHRLGLVTWLVSPDEVDPFTDDLALRLAAAPPVAVRLDKELLNHSHERSFREAVAAENVAQVVNMGTDSPTAREALARGERPAFTGRWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPR7</accession>
    <name>A0A1H6DPR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR HTH family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_120109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87312">
        <property type="protein sequence ID" value="SEG87312"/>
        <property type="gene ID" value="SAMN04489712_120109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="23136" checksum="CFAE6A70F040871D" modified="2017-01-18" version="1">MRISELSERSGLPVQTIKFYIREGLLPRGVASAATRAEYDQTHLDRLRLIRALREVGNLPVAAIRRIVEAVEDPAVGLHDLFGTAQYALRPRVQAPEDDPDWGAARRDVDALIAELGWQVTERAPARDLLTQTFVALRRLDFTVTPDDLRPYVEAAVALAEHETGGLAEDASRARAVRGMLATVLYEQVLIALHRLAQEDASARHFGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQI7</accession>
    <name>A0A1H6DQI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 family transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_120147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87511">
        <property type="protein sequence ID" value="SEG87511"/>
        <property type="gene ID" value="SAMN04489712_120147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="282" mass="29682" checksum="90F2F572CF5229D0" modified="2017-01-18" version="1">MTAPATSRPGTSASTDDPPARFGDLLAAEWIKLWSLRSTFWVLGLGALTLIGLNVQATLADHRLMASWSAQRLADYNWMNDAFGQSPYLLLMICTGAIGAITIAGEYTSGLIRTTFAAVPARRSVVAAKAAVVTVVMTILGTVVAVTSFGVTQAILSTRGGGYSFTDPGVPQAIAASALIAPVCALIGMGVGALIRHTAASVIGVFAVLVMLPELTKGRSYAWVVDLHNAMPWPAWATLRNSPWQDVPDPYAATATGSWIVLALWPLAAVLLATLAVHRRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQK0</accession>
    <name>A0A1H6DQK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_120117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87354">
        <property type="protein sequence ID" value="SEG87354"/>
        <property type="gene ID" value="SAMN04489712_120117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="262"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG87354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="384" mass="40069" checksum="37F23AC6F56A71AE" modified="2017-01-18" version="1">MAEAYIVDAVRSPVGRRGGGLSGVHPADLGAHVLTALMERTGVDPGAVEDVVFGCVDAIGPQAGDIARTCWLAAGLPEHVPGVTVDRQCGSSQQAVHFAAQAVLSGTSDLVVAGGVQNMSQIPIGSAMTAAAPLGFTDGPFAGSRGWTARYGDVEVSQFAGAEQIAREWDLSREDMEAFAYRSHQRAIAAIDGGLFTKETAPLEGVSDDEGPRRDTTLEKMASLKTLMDGGRLTAAVSSQISDGAAALLIASERAVREHGLTPRARVHHLSARGEDPIRMLSAPIPATEHALRKTGMTIDQIDAVEINEAFASVVLAWLKDTGADPARVNPHGGAIALGHPLGATGARLMTTLLHHLERTGGRYGLQTMCEGGGQANVTIIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DS06</accession>
    <name>A0A1H6DS06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized OB-fold protein, contains Zn-ribbon domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_120124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87395">
        <property type="protein sequence ID" value="SEG87395"/>
        <property type="gene ID" value="SAMN04489712_120124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="4">
        <location>
            <begin position="11"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DUF35_N" evidence="3">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="2">
        <location>
            <begin position="256"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG87395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="338" mass="37627" checksum="1B033B06A3237CAA" modified="2017-01-18" version="1">MNEYEERLRSWVGRELSVPKPGQDPVNVPMIRHWVEAMADPNPVYLDEEAARATGRDGIVAPASMMQAWTMRGYAATVNPRPGAGDGMAELIALLDEGGYTSVVATDSEFEFHRELVPGDHVSAGEVVEAISPEKNTALGAGRFITTVRTYRDQDGEVVAVQRWRTLRFRPKAPQERPEAPQERPEAPQERPEAPQEREKPRALRPRPAVNLDNAFWFEAAREHRLVVQRCAACKALRHPPGPCCPQCGSFDWDTVDSAGDGHVYSYVVNHHPPHPAFDMPYIVAVVELAEGTRLITNLTGVAPEEVEIGMPVVLEWLEADPELTLPVFRPAAPRKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTK7</accession>
    <name>A0A1H6DTK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88580">
        <property type="protein sequence ID" value="SEG88580"/>
        <property type="gene ID" value="SAMN04489712_12236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="103" mass="10495" checksum="D4381ED941EAF2C4" modified="2017-01-18" version="1">MKLRPGRQVASTVDGTRMIVVRAPGDDIVLTCGGAEMVDPAEAGTGEGGVADPGQQEGTVLGKRYTHDGLGLELLCTKPGQGTVAVDGEPLVLKEAKPLPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWG7</accession>
    <name>A0A1H6DWG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89611">
        <property type="protein sequence ID" value="SEG89611"/>
        <property type="gene ID" value="SAMN04489712_1244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="465" mass="50327" checksum="C6182DD2BF5574A6" modified="2017-01-18" version="1">MPHAALSPVAVRDMAAKMNRSDFRQWAARTRALGGCVQPVHLRGRVEHLDPLTGEVLHRYTTSCEPGGTLRVACKTRRASRCPACAETYRADTYHLVRAGLVGGKGVPESVTAHPAAFVTLTAPSFGPVHARREKPGGTVQPCHPRRDAGKCPHGRRLSCTARHSADDPRLGEPLCPDCYDHTGSVLFNALAPELWRRFTLALRRRLAKAAGLTVTALGDALTVSFAKVAEYQRRGVVHFHAVIRLDGPGGPAATPPGWVTYATLAEAVQQAARAVTVTTPDSNEAPARSLAWGTQLDVRPITTTGELTDKAVAGYIAKYATKAAECVGTLDRRIRATDDPNALPVSAHARRLITACLRLGALEEMAELRLAEWAHMLGFRGHFSTKSRHYSTTLGRLRTDRTTHNQRKHEITTGRLPLTDEDQVLVIADWRYIGQGLTPGEVLLTAALTGTPLPPINPRDGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWI5</accession>
    <name>A0A1H6DWI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argC</name>
        <name evidence="7" type="ORF">SAMN04489712_12394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89444">
        <property type="protein sequence ID" value="SEG89444"/>
        <property type="gene ID" value="SAMN04489712_12394"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG89444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="34741" checksum="42047476D8FE77F1" modified="2017-01-18" version="1">MGIRAAVAGASGYAGGELLRILAGHPEFEIGTLTAGANAGAELGSLQPHLWPLAGRVLAETTAETLAGHDVVFLALPHGQSGPLAEQLGDDVLVVDCGADFRLRDAADWEGFYGSPHAGTWPYGLPELPGQRAVLRDTRRIAVPGCYPTVSTLAMFPAFAAGIAEPDVVVVAASGASGAGRSLKPHLLGSEVMGSVAAYGVGGVHRHTPEIVQNLGAVAGEPVTVSFTPTLAPMSRGILATCTARVRPGVGAAAVREAYESAFDGEPFVRLLPEGRWPATAMTLGANTALVQVALDERAGRLVAVAAIDNLTKGTAGGAVQSANLALGLPEELGLTTIGVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXA1</accession>
    <name>A0A1H6DXA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4829 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89829">
        <property type="protein sequence ID" value="SEG89829"/>
        <property type="gene ID" value="SAMN04489712_12481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032256">
        <property type="entry name" value="DUF4829"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16111">
        <property type="entry name" value="DUF4829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4829" evidence="1">
        <location>
            <begin position="44"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="158" mass="16883" checksum="7FD73B2198766DA3" modified="2017-01-18" version="1">MEPGLGGVRIPLLVLLAGVALVTGCGSEGPKSRVGIPPVGASPQEVVTAYVAAINAHDKEAGRRLSTPHFAQQQEGGEDDQFRNIVEISHLQVQTPLSNGGHESADGKRYQDAVYVPVTFILKQREVVSMPNGHTAWGYILVRTGADQPWRINDHGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXA6</accession>
    <name>A0A1H6DXA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation elongation factor 2 (EF-2/EF-G)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89215">
        <property type="protein sequence ID" value="SEG89215"/>
        <property type="gene ID" value="SAMN04489712_12343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="25"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG89215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="720" mass="77066" checksum="DA2D85D82A02FCE0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYJ8</accession>
    <name>A0A1H6DYJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske [2Fe-2S] domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90397">
        <property type="protein sequence ID" value="SEG90397"/>
        <property type="gene ID" value="SAMN04489712_12625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="41"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG90397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="422" mass="48004" checksum="883C184D1AD9AF60" modified="2017-01-18" version="1">MTERSVVDTGTGYGRRKPSHDARLTEVGPGTPMGEAMRRYWHPIATSATLTPDVPHRTRVLGEDLIVFRDGRGRPGVVFERCAHRGASLYYGRIEEDGIRCCYHGWKFDVQGRCLEQPCEPDQGRRRDVARQPWYPVEERYGLVFAYMGPPERKPVLPRYDCLEPQEEGERYHTEWPVPGMTVTGLQQDFNWLQIYENAIDPGHINWLHSQHSGFQFLGTGNTGFPEDFYDPYTVSDRLTYKRTEYGAKYGIRFLDKEEDGVRPERAWGAELHLPNVLVLPDFVKLVPDAPADMLLWVVPSDDTSHRSFFSLRTTDPERLDRFLLGVKQNGKDPWELTEEERQRYPGDGEAQQSQGPITLHSEETLATTDRGVVMLRRLLKAMVDDVEAGRDPQGVSLVEVPPRRTEAGMFTLSATAPAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYZ8</accession>
    <name>A0A1H6DYZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Act minimal PKS ketosynthase (KS/KS alpha)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_1267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90339">
        <property type="protein sequence ID" value="SEG90339"/>
        <property type="gene ID" value="SAMN04489712_1267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="9"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG90339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="426" mass="44698" checksum="2483BB53483CBC1B" modified="2017-01-18" version="1">MSGGHVRRPVITGVGVTAPGGVGVKEFWKLLTDGRTATRRISFFDPSPFRSQVAAEADLDAELSGLTPQETRRMDRAAQFAVVTAREAVADSGLDFAGLPPHRTGVTVGSAVGATMGLDQEYRTVSDGGRLELVDHTYAVPHLYNYMVPSSFATEVAWAVGAEGPATVVSTGCTSGLDAIGYAADLIREGSADVVVAGATDAPISPITLACFDAIKATTPRNDDPEHASRPFDATRNGFVLGEGAAMFVLEDLDGARARGATIYAEVAGFATRSNAFHMTGLRPDGREMAEAIRVALDAARLAPEDIDYINAHGSGTKQNDRHETAAFKRSLGEHAYRTPVSSIKSMIGHSLGAIGSIEVAASILAMTHDVVPPTANLHHPDPECDLDYVPLTAREQRVDAVLSVGSGFGGFQSAIVLADPERSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0I6</accession>
    <name>A0A1H6E0I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90889">
        <property type="protein sequence ID" value="SEG90889"/>
        <property type="gene ID" value="SAMN04489712_12768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="161" mass="17919" checksum="9CCEB098D59BA042" modified="2017-01-18" version="1">MEREWVAEESVLVAAEPARVYAAVADLRRMGEWSPECFGVWVRGGRVEPGTGFVGFNRIRWRVWFTTGRVTAAVPGAAFAFRVSSFGMPVALWGYRLEDVGDGSTRLTEYWEDLRRDHRGAALVSLLGKVFTGVAAEERAELNRRGMRTTLGRIKAALEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0P9</accession>
    <name>A0A1H6E0P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_12655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90495">
        <property type="protein sequence ID" value="SEG90495"/>
        <property type="gene ID" value="SAMN04489712_12655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG90495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="226" mass="25028" checksum="CB98510FE11DE956" modified="2017-01-18" version="1">MTASASPAAGGDGLDGGEGSCLARIRQLVLTGQLLPGQKVNQGEIAARLGVSRVPVREALAALRSEGLMESRANTGFTVVRPTVDDLVEIYLMRNLLESELLRSVDLAAVDVELLERVNGEMARLDPVVSFEAYRLANERFHFAIFDRASLRLVRREVGRLWTLSEFYRSIYIHGEGAHQRVIEDHVRIIDAVRRRDHEALVAVSTEHRGETEISMSRVLGRRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2M7</accession>
    <name>A0A1H6E2M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91872">
        <property type="protein sequence ID" value="SEG91872"/>
        <property type="gene ID" value="SAMN04489712_1319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="238" mass="26029" checksum="E0DD3CB735C605DF" modified="2017-01-18" version="1">MSAPERTVAPAGLPTTADLDGFPSGVAANETLRTIGTARAMRRLRPDPVPDELIRTLVWAGTRAASPNNSQLWRFVVVRDPGRRAAIGAALERFVRWIDSLGKPADDGDAHIRAEARHLVVNVAQAPVLLFVCAEHSYPERGPDPRYLWSAVNTASQNVLVAARSLGLGATLTMMQVGNEQGVRDVLGLPDDVHIGTMIPVGWPDRPFGPARRRPLDDVIHHDRWRGGSRVQDERDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3C8</accession>
    <name>A0A1H6E3C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92067">
        <property type="protein sequence ID" value="SEG92067"/>
        <property type="gene ID" value="SAMN04489712_13210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="14678" checksum="A2376E96FB66E9FC" modified="2017-01-18" version="1">MTEAMDNRLGWMLDDALRMPETRQAILLSADGLLMAHSERISRDEAERQAAGMSGLQSLARSTAEFCGGADSAWRQTVTEFDDGYVFLVAAGPGAYLAVSATPQVDMEAVSFRLQELVQRLGKELTSPPRRGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3G3</accession>
    <name>A0A1H6E3G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monosaccharide ABC transporter substrate-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000029">
        <property type="protein sequence ID" value="SEG91546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91546">
        <property type="protein sequence ID" value="SEG91546"/>
        <property type="gene ID" value="SAMN04489712_12955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="374" mass="38943" checksum="5705081B2D48F8F9" modified="2017-01-18" version="1">MAEAGGRTASHSGEDESSRVPAVDRAITVLYEIADHGPASLADLTRRLALPKSSLLGICQSLVEERLLAQDLGGRYVLGLGLAELAAAQLQHPPGLSRLGMSVPNGTNPFYAVEIEGVRRAAAELGAEVTAVDAGQDVDEQARQLGRFVRDRVDAIVLDAVHSTAIAAAVAEAEAAGVPVIAVNVGAEGASATVTTDNVQAGQMIGRYLATVLDGKGEVAIVDGQPVTAVADRIVGFMAALRDFPGLRVVARHRGDHSPQSGERIARRLLDRHPGLSAIFAINDPMAMGVVTALVDLGVSIPVVSVDGAAIAVSSIGTDGPWWATAAQDPAGLGGLAVRFAARLRSGDPPHSRRRMLPTRLITRENIADYEPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6D5</accession>
    <name>A0A1H6E6D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_13538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92813">
        <property type="protein sequence ID" value="SEG92813"/>
        <property type="gene ID" value="SAMN04489712_13538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG92813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="6936" checksum="110EB21D3689012A" modified="2017-01-18" version="1">MPGKVAGFPRATDLEPAERAALDQGVTVRRGQGYTLRVSAVPAVHRQLLTRCEPLDGGQGIPAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E865</accession>
    <name>A0A1H6E865_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93887">
        <property type="protein sequence ID" value="SEG93887"/>
        <property type="gene ID" value="SAMN04489712_14121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="89" mass="10162" checksum="EFF2C37175EDCBA5" modified="2017-01-18" version="1">MNEPRLQQRFGHVADRRPHGSGYGGRMGVYVVHDSETGEDFTFSYVDIVTEGFRTVRTGERVRFMTDPDQPGTAVYVIRLDLPDVEAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8N3</accession>
    <name>A0A1H6E8N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94082">
        <property type="protein sequence ID" value="SEG94082"/>
        <property type="gene ID" value="SAMN04489712_1436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="41893" checksum="A43766C912E2C5A0" modified="2017-01-18" version="1">MNHLYYLLAATCWTAAAYKARDLRRAPASPALQGTCLTLGLLGLAFLVLADSSRTVIDRVAGVEDLARWVGNSCTLAAGCSIQIVLAHFTRAPGSPAPDIRPRIALLAGAVIPMGVLMLTEQPPDCTDFVNVHAHRGPVVAYLLIYLSYLGLVMADALRLSWRYAPHAGSGPLRLGLRLIAVGSSLGLLYCLYKAAFALCRFWGLPTIGTEGVVGPALGLLAALLIVAGLTVGAWGAALTEHLQRWRSYRRLEALWRPLVQAVPQVVLPTEQQGVAEKLYRRVIEIRDAQLALSPYRDDAFAVQARRAAQNAGLTGQDLEAAVEGTVLAAALAAKRLGRRSSDAVLTDMKDQVGPDLASEVAWLEKVTVAFISPLVPPSHVADSRATEATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EB96</accession>
    <name>A0A1H6EB96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94329">
        <property type="protein sequence ID" value="SEG94329"/>
        <property type="gene ID" value="SAMN04489712_14616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="119" mass="12800" checksum="D027B15240186BB8" modified="2017-01-18" version="1">MRQAFAHEAVVAMDPGQDIRAPGAAITVALCGHWEHQPPCPLAPHHTDARRSGTRVRLRVLFASAPAAEASVRTRIEQALSESSLTGPDGVTTHWRLLNTQPSAVRTGEAEHAEQLIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SC04</accession>
    <name>A0A1H5SC04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48112">
        <property type="protein sequence ID" value="SEF48112"/>
        <property type="gene ID" value="SAMN04489712_101150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF48112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="15916" checksum="6BCC1996C9BE6EC2" modified="2017-01-18" version="1">MHPNVERVAAALKELGATGQIVELPEAARTAEAAAEQLGCPVGAIANSLVFAADDTPLLVLTSGAHRVDTAKAAALAGARRVRRATPEFVREATGQPIGGVAPVGHPAPIRTLVDTWLGEHEVVWAAGGHPHTVFPTSFEELVRITGGTPADVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SF30</accession>
    <name>A0A1H5SF30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49283">
        <property type="protein sequence ID" value="SEF49283"/>
        <property type="gene ID" value="SAMN04489712_101187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF49283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="149" mass="16376" checksum="3AA3171A6F1282CE" modified="2017-01-18" version="1">MRSSDLPSLPVVWRPRRTRIVAYTMAGVIVLGMVVLAIVVAPPFTVFDRVLLVALGLFLGWLLHMFARCRVVADQRGVTVVNAFRTRRLEWPEVLSVTMAPGEPWPTLDLADGTSIGAMGINGAEKPRAAHQLTELRALLAEHAEAPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SHH4</accession>
    <name>A0A1H5SHH4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="15" type="ORF">SAMN04489712_101184</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF49197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF49197">
        <property type="protein sequence ID" value="SEF49197"/>
        <property type="gene ID" value="SAMN04489712_101184"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="227"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="159"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="221"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="271"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="315"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEF49197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="421" mass="45594" checksum="3FF2FFCF65D86BC4" modified="2017-01-18" version="1">MTGDQTDGRTDGMDETVNSGIFDPVEDALADIAAGKAVVVVDDEDRENEGDIIFAAAKATPELLAFTIRYTSGVICMPMLGEDLDRLQIPLMTAQNRDRMRTAFTVSVDARDGVSTGISAADRARTIRTLCDSATEPYEIVRPGHIFPLRYHEGGVLARRGHTEASVDLARLAGLPPAGVLAEVVNDDGTMARLPELQVFAKEHGLKLISIEQLVEYRKRTETMVRREVETRLPNRYGTWRAVGFSSAIDGGEHVALVYGDIGDGEDLLVRAHSECLTGDVLHSERCDCGTQLDAAMEAIAAEGRGVVLYLRGHEGRGIGLLAKLRAYALQDAGSDTVDANLELGLPADAREYSNAAQMLLDLGARSIRVLTNNPAKLAGLKGFGLEVRGRVPMPVVPTEHNLRYLTAKRDRLGHRIEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SR62</accession>
    <name>A0A1H5SR62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpC</name>
        <name evidence="10" type="ORF">SAMN04489712_101331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53086">
        <property type="protein sequence ID" value="SEF53086"/>
        <property type="gene ID" value="SAMN04489712_101331"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEF53086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="268" mass="27851" checksum="2AF4335EF632D86F" modified="2017-01-18" version="1">MSVLEEILEGVRADLAERQAAVPLEALKEKAAAAPPPRDALGALRSDGVSVIAEVKRSSPSKGALAAIADPAALARDYEAGGAKVISVLTERRRFGGSLADLAEVRANVDIAVLRKDFIVTAYQLWEARAHGADLALLIVAALEQDALVSLVERAESIGLVPLVEVHTEEEVARALEAGAKVVGVNARDLKTLRVDRGVFARLAPLIPRDVVKIAESGVRGPHDLLAYASSGADAVLVGESLVTGGDPRSAVADLVAAGAHPALRQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SUL0</accession>
    <name>A0A1H5SUL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF54272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF54272">
        <property type="protein sequence ID" value="SEF54272"/>
        <property type="gene ID" value="SAMN04489712_101372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF54272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="122" mass="13269" checksum="4A237EB06BB722AF" modified="2017-01-18" version="1">MRTVGGMTSMTLRREDDFSVTVLRHADRAVVYVSGDIDLSTEGHLRQALLSLIGGRVRKVIVDLRDVGLFGSDALRVLAQAQRVADVADVSLILAAVPRGALRIIEITGMVDTFNIRRLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T4F8</accession>
    <name>A0A1H5T4F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Golgi phosphoprotein 3 (GPP34)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57690">
        <property type="protein sequence ID" value="SEF57690"/>
        <property type="gene ID" value="SAMN04489712_101480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF57690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="28550" checksum="CC35475951F861DE" modified="2017-01-18" version="1">MTPPEADNGRPSLTLPEDVLLLCAQPGTGRLELPRYVNRPLAGAVLAELALRGAIVIQDDQITEVRPLTVGDPVTDRLLARLIDDVRLGVPGLHRIRLADHGDEHPAPRGRFAAARGAMFAAAAQVRPPWRLEEWVTWPRFHALDQGYLQALHARGLLTAARRRTLGFLPRTAWASTAPDHAARTAARITQAIHSHGPGHDDSRSLRLAALAAAADLTGRLFPGTRHDDMRYRVEHLAHTDPIAVAVLKAISSDRLRNAGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T5R4</accession>
    <name>A0A1H5T5R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_101474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57508">
        <property type="protein sequence ID" value="SEF57508"/>
        <property type="gene ID" value="SAMN04489712_101474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="244"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEF57508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="415" mass="44898" checksum="423CFC915FE497F1" modified="2017-01-18" version="1">MPDTPEQAAFRARARAWLAANAPEFAGTVRHRLHFEAARSAEQYEKDEAESVRAAQAWQARLHEGGWAGISWPKPFGGHGGTPAEEAVFAEEAAAHDVSTGPLLIGLAMVGPTLMRHGTPEQRAEHLPPLLRGERVWCQLYSEPEAGSDLAALRTRAVLDGDTWVVNGQKVWTSSARVADWAILLARTDPDVPKHQGITYFLVDMRTPGIEVRPLRQMNGSYHFNEVFLDDVRIPAGHVVGEVGGGWKVAHTTLASERAMIGGGGGAKAGALLALARAHGRDTDPLVRQRLAEVHTLDEILRILGLRMRAALNRGRPPGPEGSIMKLLVARRAHRAAELGLAIEGAGGLLTGQDAPGGGDWQQQLLSAQGLRIGGGTDSIQRNAIAERILGLPRDRAADRDVPFRELITRRAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T8A0</accession>
    <name>A0A1H5T8A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA:oxalate CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58984">
        <property type="protein sequence ID" value="SEF58984"/>
        <property type="gene ID" value="SAMN04489712_101520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF58984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="401" mass="42531" checksum="5A53C5AEFAE15C3A" modified="2017-01-18" version="1">MGRPLDGVRVLALEQMQALPYATQLLARLGADVVKVEPPRGGDSGRASLPAMTDPQGRRVGATFLRNNLGKRSICVDLKDPRGRDLVLRLAPRFDVVAENSKAGAMRRLGLGYDDIAAVHPAAIYVSVSGFGNTVPTPYGDRPAFAPIVEAMSGVYEMKRTGDRPPTVAPVGALGDIGAALYAAIGVLAALRHREATGRGQYVDIAMLDAVIAMTDIVTNLWSMGLRGGQLGPLILHGFRAKDGWFVLQVAREQHFARLVELIGHPEWAADPRFATRQGWVAHLEDVLRPAIEGWAAGLTKAQACQAMGAAGIPAGPCLGAEEVVADEHVAARDMLVSVPRTDGVAQPVLVPGDPVRMSAVPRADETRPPWLGEHTSEVLSTELGLTSAEIQTLRSAGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T8L5</accession>
    <name>A0A1H5T8L5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58431">
        <property type="protein sequence ID" value="SEF58431"/>
        <property type="gene ID" value="SAMN04489712_101503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF58431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="168" mass="18234" checksum="A80E04D56241C8E6" modified="2017-01-18" version="1">MADARTEPGAGRNDATRNDNAPAEGVPAEDVRTGDVRAVRDELEIRTVLARIAQLSDMGDLDDYGAQFTEDAEWEMPGVPPKHGRAEIRAAGAARRAQGATGPGSRTRHVVGTVAVTVDGDAAVAESYWQFYTDTATAPRLHSMGHYRDTFRRTSQGWKLARRQITLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TNF1</accession>
    <name>A0A1H5TNF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase family protein, VC1184 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64300">
        <property type="protein sequence ID" value="SEF64300"/>
        <property type="gene ID" value="SAMN04489712_101688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011340">
        <property type="entry name" value="Cys_dSase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01976">
        <property type="entry name" value="am_tr_V_VC1184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="22"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF64300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="42835" checksum="82A010F385BCEFDF" modified="2017-01-18" version="1">MAYDVAAVRAQFPSLKAGCAHFDGPGGTQTPLPVIDAIADALANPLSNRGHGTPGERNADTIVGDARQAMADFLGAHPSGIVFGRSATQLAYDFARALAKTWSPGDEVVVTRLDHDSNIRPWIQAAQSAGATVRWADFDPATGELHPEAIGAVLSERTRLVAVTAASNLIGTRPAVAEISRSVHDAGALLYVDGVHYAAHVSVDVERLGADFFACSPYKFLGPHLGVLASRPELLDTLRPDKLLPSTDVVPERFELGTLPYELLAGARAAVDFIAGLGPRTEGGRRARLVSAFAALEEHEDVLRRRIEEGLSALEPVTVHSRAAERTPTLLMTIDGRSTVDAYHHLAERGVVAPSGSFYALEASRRIGLGDDGGLRVGLAPYNNAEDVDRLLQGLADFLRQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TNH8</accession>
    <name>A0A1H5TNH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64334">
        <property type="protein sequence ID" value="SEF64334"/>
        <property type="gene ID" value="SAMN04489712_101689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF64334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="447" mass="48810" checksum="9DAFE2ED716AC4DE" modified="2017-01-18" version="1">MSVHGTEESNVTTSPSAYPVDVLIVGGGIGGLSAAFALAREGLRVRVLEQAREFGEVGAGLQIAPNCTRILHDYGLLDEAKHLGVLPKSMVMRDAVDGSELTRLDLVDLEREYGFPYMVIHRSDLHGIFLRACRRAGVDLITDARVSGYENTVSGARVLLADGRVDKARIVIAADGLHSVARRLLVDDEPVSSSYVAYRAALPIEQVGRDVDLSEVSVHVGPRCHFVRYGLRGGAMLNQVAVFQSPKALAGEEDWGTPDELDDAFAATCPDVQAGIPLMWRDRWWRMFDRDPIMTWGDGGIALLGDAAHPPLQYMAQGAIMAIEDGWVLAKHVAARRAEDGSIDWQGALAAYEAVRPEHCRRVLTTARAWGELWHLDGVARLQRNTLLRARDTYDYSFTDWIYGPTALTPEEEPPMFSPIPLDSVDVSGLADRVEASPVPAEHSPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TP31</accession>
    <name>A0A1H5TP31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64544">
        <property type="protein sequence ID" value="SEF64544"/>
        <property type="gene ID" value="SAMN04489712_101695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="17"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF64544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="312" mass="33824" checksum="C9B2ABFF467131B1" modified="2017-01-18" version="1">MTHVNVHPLVSPWGRFGLYSFFIDAPQPAIVDTGIASSPTEGMAPALEAVGRRIEDVRWILLTHGHIDHVGGAHALWELTGRRAQVVIHQADAPMLRSRRAHVDEYLHGRARYLNDPEGEAKVTAAANAVISGEMEPTMLLKGGETLSLGGGVTVSVHAVPGHTPGSVAYVIDGQRSVFVGDAVQVHGAANGFPGYMDPAAYRASLRYLRDEIRPRHLYLGHPYRRADGMPYGVELDADQAREALQGSLDIEAGVGEAACRCLQDGLRETNSPYSPFAPVAERLGYTGDPTLEPSPFFTSMHGYRTHFDQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TZA7</accession>
    <name>A0A1H5TZA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-(Acyl carrier protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67518">
        <property type="protein sequence ID" value="SEF67518"/>
        <property type="gene ID" value="SAMN04489712_101783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF67518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="27661" checksum="FFCACC6100951C69" modified="2017-01-18" version="1">MTAAQQHSGEAGAGLLRGQWAVVTGGSKGIGYAIAERFVGEGANVLIAARDKAALDEAAGRLRALAGDGQRIESLPADLGGRAGIDALFDHIARELPVLNIFVANVGYGIFRSFLEVTDEEWDGIVSTNLTGTFRCTQAAARLMRDRPADNRAILVISSIRAQGARPNTLPYSTTKAGLNQLVRVAAYELAPLGIRVNALSPGLVVTPMALSHNPQAAELGAELAPLNRAGMPSDMAEGALYLCNPAASFVTGTNLVVDGGESLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U1Q2</accession>
    <name>A0A1H5U1Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68181">
        <property type="protein sequence ID" value="SEF68181"/>
        <property type="gene ID" value="SAMN04489712_101807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF68181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="221" mass="24668" checksum="16CD906E7EBD2A84" modified="2017-01-18" version="1">MPEHTAKERLREAAFALFEERGYERTTIDDITERAGVGRTTFFRTFRSKEDVIFPDHEALLAAVRARLAGSTRQTALVAVCEAARLVLLHYLDEGELALARYRLTRSVPALRDRESADTLQYQRVFREFVHTWMGGGQDTALRAELTAAAVVTAHNHVLRRWLRGLTEEPEAEFDAAMARTLALFTEPATKGDTGSIVAFRTTKDLDAILPALRGILGEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U4Q4</accession>
    <name>A0A1H5U4Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF69257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF69257">
        <property type="protein sequence ID" value="SEF69257"/>
        <property type="gene ID" value="SAMN04489712_101846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF69257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="245" mass="26465" checksum="E8C9F8BEAE996AF3" modified="2017-01-18" version="1">MSRLLELSGLSAGYGGVRALDGLDLHVDEGEFVVLLGPNGAGKTTTMKTVSGLLKPNSGRITFAGRDLAKVPGWRRAGLGLGHVPEGRQIFPEHTVLENLALGGFPTRHRRGENERRRDELLEIFPRLAERSSQLAGTLSGGEAQMLAVARALMAGPRLLMLDEPSLGLAPLKVAELFGYLKRLHAEHGLTILLVEQQAGTALRLADRGYVLERGRVVVEGTAAELRDDPRVQAAYLGRLRQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VHP3</accession>
    <name>A0A1H5VHP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86576">
        <property type="protein sequence ID" value="SEF86576"/>
        <property type="gene ID" value="SAMN04489712_102321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF86576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="66" mass="7078" checksum="1BA31FF6C3223D37" modified="2017-01-18" version="1">MSDATKIEWRKSSYSDAGSGDCVELATLPGVVGIRDSKNPAAGHLQVGRRHLAALFTEVKTGRHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VLY3</accession>
    <name>A0A1H5VLY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88244">
        <property type="protein sequence ID" value="SEF88244"/>
        <property type="gene ID" value="SAMN04489712_102372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF88244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="27609" checksum="90FC3A69B8AEE84A" modified="2017-01-18" version="1">MTEIVYPPVIAAAKAMFRALDLRCTVEGAHNIPRTGGAVLVSNHISYLDFIFAGLAAQPARRLVRFMAKKEVFDHRISGPLMRGMKHIPVDRQAGAAAYRDALNALKGGEVLGVFAEATISRSFTVKDIKGGAVRMAASAKVPMIPMALWGTQRLWTKGRPRNLRQRHVPITILVGEPMHPTRVRDFTPVVDELHTRMSRLVERAQREYPELPRPGEEWWQPAYLGGTAPTPEEAAAMDKAEAEDRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VRS9</accession>
    <name>A0A1H5VRS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rph</name>
        <name evidence="7" type="ORF">SAMN04489712_102434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90009">
        <property type="protein sequence ID" value="SEF90009"/>
        <property type="gene ID" value="SAMN04489712_102434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="160"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF90009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="239" mass="25789" checksum="C54B509D737091CC" modified="2017-01-18" version="1">MARPDDRAPDQLRPVRIQRGWLDHAEGSVLVEFGGTRVLCAASVQDSVPRWRRESGLGWVTAEYAMLPRATNTRNDRESVKGRLGGRTQEISRLIGRSVRACLDFKALGENTVVLDCDVLQADGGTRTAAITGAYVALADAVAWMRARKMTKGDPLITSVAAVSVGLIDGEPRLDLCYAEDVKAGTDMNVVATGDGRLIEVQGTAEGRPFDRAELDALLDLALGGCAELTRLQREALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VXQ7</accession>
    <name>A0A1H5VXQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92069">
        <property type="protein sequence ID" value="SEF92069"/>
        <property type="gene ID" value="SAMN04489712_102510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF92069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="215" mass="23438" checksum="FDC840BB8EF58DED" modified="2017-01-18" version="1">MRVVIAEDSVLLREGLVRLLADAGIETVAVVGDGPGLLETVQEHRPDLAIVDVRMPPSFTDEGLRAALRVRQSRPRQPILVLSQYVEERYATDLLGGGAQGVGYLLKERVSDVGEFIDAVRRIAAGGTMIDPEVIGQLLGRRRDGDRLEALTPREREVLGLMAEGRSNAAIARELVVTEGAVEKHISNIFLKLDLPPTQHDHRRVMAVLAFLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W929</accession>
    <name>A0A1H5W929_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">secA</name>
        <name evidence="20" type="ORF">SAMN04489712_102634</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95974">
        <property type="protein sequence ID" value="SEF95974"/>
        <property type="gene ID" value="SAMN04489712_102634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="2"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="88"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="422"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="843"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="875"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="906"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SEF95974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="946" mass="106189" checksum="A5D245064C2721FD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WBW1</accession>
    <name>A0A1H5WBW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96681">
        <property type="protein sequence ID" value="SEF96681"/>
        <property type="gene ID" value="SAMN04489712_102653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF96681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="352" mass="38352" checksum="D97740B81E21F3D6" modified="2017-01-18" version="1">MEYRRLGASGLEVPALSFGAGTFGGRGPLFGAWGDTDAREARRLVDICLEAGVTMFDTADVYSDGASEEVLGQAISGRRDQVIVSTKTGLPTGDGPGAAGTSRARLVRACEDALRRLGTDRIDLLQLHAFDAGTPIEEVLSALDDLVRAGKVRYVGVSNFSGWQLMKSLAIADRYGRPRYVAHQVYYSLAGRDYEWELMPLGADQGVGALVWSPLGWGRLTGKVRRGRPLPVQSRLHRTADYGPPVDDELLFRVVDALDEIAEETGRTVPQIAINWLLQRPTVCSVIIGARTEEQLRQNLGAVGWTLAPEHLAKLDAASTVTAPYPYFPYRRQEGFARLNPPLETRMSSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WE16</accession>
    <name>A0A1H5WE16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97431">
        <property type="protein sequence ID" value="SEF97431"/>
        <property type="gene ID" value="SAMN04489712_102677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF97431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="298" mass="33036" checksum="9CA3B0509DC9A6EA" modified="2017-01-18" version="1">MTVVCRTRTWRPPWPLDVAGTLEPHCRGRHDPAYRVTADGAVWRASFTPDGPGTLRVRERADLGVVEASAWGPGAGWLLDGLPELLGAEDEPGSLEPVHAVVKEGLARWRGLRVGRSNRVFEALVPAVLEQKVVTTEAWRAWGYLLRRFGEPAPGAPEMRVPPPPAVWARIPSWEWHRAGAEAVRARTIVNAARAASRLEEDAAERRLRSLPGIGVWTAAEIRQRAVGDPDAVSVGDYHLPALVGWALAGRRVDDAGMLELLEPYAGHRYRVTRLLERSGPRPARRGPRMPVRDYRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X9Q7</accession>
    <name>A0A1H5X9Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08087">
        <property type="protein sequence ID" value="SEG08087"/>
        <property type="gene ID" value="SAMN04489712_103141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG08087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="60" mass="6590" checksum="9CAE4DB27FB7FD0D" modified="2017-01-18" version="1">MSERAVPFYCPYCGDEDLVPYEADGSWHCRACARAFQLKFLAVRAPHTAGTPAADDGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X9T9</accession>
    <name>A0A1H5X9T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PucR C-terminal helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08534">
        <property type="protein sequence ID" value="SEG08534"/>
        <property type="gene ID" value="SAMN04489712_103158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="249"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG08534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="365" mass="40524" checksum="C745E92AAADA2284" modified="2017-01-18" version="1">MTKKTRTLAGGEARTGERRRLHQLTPDPKPQAWHDDFERAFEQPEDLARHGPEHTDRLWCAAGALATAENAEGPCRCDGPCDVHRRDLLELLLRSPCDPDRLRKAAVRAGWEVPRTLAAVAMYRAPRPVPARRFLPPNVLTGLHQGLPCLIFPDPDGPGRRAVLRALLSEDPGVVGPTVETCRAGSSWRLARRGLELLPADLPARHTAVHVLDHVRDLLLLQDRGLSRELAARKLAPLQRLRPARRACLAETLLAYLECGRSAVAIAERLHVHPQTVRHRMRQITHLFGPDIDDPSQALDYLIALHTWRLLPDDHSSPHGGHRLDDAAPRQGPHGGPPRRQGGATGGSHRRSPRKNQRKAAPHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XJJ0</accession>
    <name>A0A1H5XJJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11803">
        <property type="protein sequence ID" value="SEG11803"/>
        <property type="gene ID" value="SAMN04489712_103281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG11803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="153" mass="16553" checksum="BCEB499551267380" modified="2017-01-18" version="1">MLARELARDFPTIDLDSDALEAARLLVERGLPGLIVVDSARHPVAVLPGSQLLRFVVPRYVQDDPTLAHVYAERQADRLADRLRGHRVRDLLPERPQRLPVVEGGATAMEIAALMAAEHSPLVAVVESGSGPEPPMIGAISVVDLLARALPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XPS6</accession>
    <name>A0A1H5XPS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG13256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG13256">
        <property type="protein sequence ID" value="SEG13256"/>
        <property type="gene ID" value="SAMN04489712_103333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG13256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="347" mass="38320" checksum="A908E2CB791108D3" modified="2017-01-18" version="1">MPQTLAPPARTRAPGSDFAPLARRVRDSGLLERRRGYYAWIIAVNVLATAGIWLAVALADGSWWAVAAAVPAAVVFARTGFLGHDAGHRQIARSPRANRWLGLLFGNLMTGMSYGWWNDKHNRHHANPNHVDKDPDVAAGVLVWTAEQAAERNGFAGWVTRHQARLFFPLLTFEGWALKVASALDLRNRPLRDALVEGGLLAAHMAGYLALAFTLMSPAQAVTFILVHQALFGLHLGCAFAPNHKGMAMPAPGERWDHLRRQVLTSRNIRGGAINDWLLGGLNYQVEHHLFPSVPRCNLRKVQPLVREHCARVGLPYTETGLLESYAQALGHMHEVGDPLRGDRDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XZ95</accession>
    <name>A0A1H5XZ95_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="16" type="ORF">SAMN04489712_103478</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16942">
        <property type="protein sequence ID" value="SEG16942"/>
        <property type="gene ID" value="SAMN04489712_103478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
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            <end position="202"/>
        </location>
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            <end position="426"/>
        </location>
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            <end position="642"/>
        </location>
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            <end position="798"/>
        </location>
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            <begin position="1"/>
            <end position="27"/>
        </location>
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            <end position="73"/>
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        </location>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG16942.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="838" mass="92590" checksum="F03DB8EAAAC1544E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y0S7</accession>
    <name>A0A1H5Y0S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mce-associated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103501</name>
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        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SEG17561"/>
        <property type="gene ID" value="SAMN04489712_103501"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SEG17561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="322" mass="32498" checksum="D41741FA881F00A0" modified="2017-01-18" version="1">MEKDTVSADGNPHNGLPATVVSAPRPNDDDPPADGTATNGRTETDGHSPSEAASRADDELPPGADGGAPSGAGAAGQAEASRDATAGGGEKAKANDGPSGEAEGTEGAGRSGGSDVGTAGEDTAATDGGPASEGDDTASPGDKTGEAGKTGGGSRSRAAWLRDPLVLALVFVVVGAALLVRAAQVRGDEAAENRALTDVERTEVVIGDVSNALGKVFSYSYANTAVTEQAARDVLAGRAFNQYQTLFGQVKQQAAAQRLTLTSRVVRAGVVRMSGDTAQLLVFLDQTVHRKDKPGGTTAAAQLSVTARLSDGHWRIVDIQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YKP8</accession>
    <name>A0A1H5YKP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="SAMN04489712_10470"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG24729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="92" mass="9742" checksum="CB95FEE56C365588" modified="2017-01-18" version="1">MPILNRGYGPAVWVARPEAAPVSQASWRKQVWPAAIALTAVIVFVAFLVPTTLPLAVIMALATVVAGGILATLVSGTAWVTRLRLLIAELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YQS2</accession>
    <name>A0A1H5YQS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
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    <gene>
        <name evidence="7" type="ORF">SAMN04489712_104121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
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            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTAD"/>
    </dbReference>
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        <property type="entry name" value="LysM_dom"/>
    </dbReference>
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        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="175"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="645"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="645"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG26150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="904" mass="97552" checksum="E40C355C5B63CC04" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YTE3</accession>
    <name>A0A1H5YTE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG27473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG27473">
        <property type="protein sequence ID" value="SEG27473"/>
        <property type="gene ID" value="SAMN04489712_104180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG27473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="29966" checksum="042480CF55AA8E67" modified="2017-01-18" version="1">MAAPRFRQIAEELIRRIDNGAYPEGTQLPTEVQLMDEFDASRNTIRDAVKLLIGRGLVHTSPGRGTFVLRAVEPFALTLASVGTAGQTSESEAYRFEARLQGREANVSDPRVEIKKAAGSVAQALGIEAGQRVVIRHQERRIDGRPWSLQTSWYPMAYVTQGADRLIDAEDIREGVVKYLQEELGVEQAGYRDKITARVPNAHEASFFNLPDSGSTVIVHDRIAYGRDKKPIRLTNTVYPADRNELYVEVGDVPPRTGPTPTVPVEGDDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YZ83</accession>
    <name>A0A1H5YZ83_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="17" type="ORF">SAMN04489712_104263</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG29331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG29331">
        <property type="protein sequence ID" value="SEG29331"/>
        <property type="gene ID" value="SAMN04489712_104263"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="172"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="318"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SEG29331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="434" mass="45460" checksum="F42BB88E313B0F1E" modified="2017-01-18" version="1">MTILVVGLSHRSAPVAMLERAAATGDALNKLLHEVHESTHVAEALIVSTCNRVEVYAVVDKFHGGVSDISELLARHSGLPLDDLARHLYVHYEDRAVQHAFSVACGLESMVVGESQILGQMREAFKLAQTEGTVGRDLHELIQQSLRVGKRAHSETGVDQAGASLVSVGLNVAEGHLGELTGRRALVVGAGSMSGLAVATLARAGVGEIVVANRTYARAERLAAAAEVPARAIELTDLTAALAEADLVVSCTGAAGLVITAEQVPATGERRFFLDLALPHDVDPAVRTLPGVALAGLDDLRTAEEAAQAVGPRAVEAVRRIVAAEVAAFLNAARAAAVAPTVVALRSKAAEVVEAELTRLTGRLPALDERDRAEIAQTVRRVVDKLLHAPTVRVKELAAAPGGDTYAVALRELFDLDPKAPEAVARPDIEGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z1S7</accession>
    <name>A0A1H5Z1S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG30281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG30281">
        <property type="protein sequence ID" value="SEG30281"/>
        <property type="gene ID" value="SAMN04489712_104302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG30281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="78" mass="8538" checksum="631803D4BD65DC2D" modified="2017-01-18" version="1">MSPKEIPPTGGLADELAAVVALRELADRLEDAAVERAMRAGWSWTQVAEALGVTRQAVHKKHLRRLVAAGIELRRRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZFV2</accession>
    <name>A0A1H5ZFV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_104542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35349">
        <property type="protein sequence ID" value="SEG35349"/>
        <property type="gene ID" value="SAMN04489712_104542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG35349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="42601" checksum="DB0F3363401822A0" modified="2017-01-18" version="1">MAIDFKASRGATLGVEWELQLVDAQTGLLRQEARQVLAALPGLSEGGEIPRLRHELMESTVEVVTGICHTVGEATADLAATIAQLRSVTASRDIELACTGTHPISDWRDAVMAPVQRYADLVQQMQWLARRIQTFGVHVHVGVRDGAKAIPIVNALAAYLPHFLALTASSPYWSGHDTGLASSRAVVWGQLPTAGPPHLLADWAEFEEYMDTLLRAGSIRSIKEVWWDIRPHPDFGTIEIRMFDGIPTLREVGMAAALCQSLVTLFDQQLDRGYTLPRPAAWVVRDNKWRATRYGLDAIVITDDGGSTAPLRDDLYELIRELEPVADRLGCAEQLKVAGEVLEHGAPYERQRAIRAEGGTLENLVKAAVTELLEDRFVSPREVAYGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZHG9</accession>
    <name>A0A1H5ZHG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_104535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35185">
        <property type="protein sequence ID" value="SEG35185"/>
        <property type="gene ID" value="SAMN04489712_104535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="8">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="109"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="301"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG35185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="396" mass="41583" checksum="8E54449BE74A1B9F" modified="2017-01-18" version="1">MNTLVAAFEEAYGRAPQGVWRAPGRVNLIGEHTDYNDGLVLPFALAQGVSVAAARRDDGVLELRSLQAAADGRSLPIDGLAPGTVDGWAAYPAGVAWVLREHGAGGASLLVDSDLPQGAGLASSAALECATALALCDLYGLEIERAELARRARRAEAEFAGVPCGIMDQSAALLCTAGHALLLDCRSGLSGQVPLRLGEDLSLLVVDTRAAHALTGGEYARRRAECEQAAALLGLDSLRDVTDLASTLERLPAVQSRPSLPFRRRSGQTGPDPATLRRRVQHVVTENHRVEATVGLLRADALAEIGGMLTASHLSLRDQFEVSWPQADATVEAALRAGARGGRMVGGGFGGSVLVLTATDRATHVREAIDAAYQARGWPAPHYQDAVPSQGAHRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZWD5</accession>
    <name>A0A1H5ZWD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40759">
        <property type="protein sequence ID" value="SEG40759"/>
        <property type="gene ID" value="SAMN04489712_10549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG40759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="193" mass="21665" checksum="59CB3F816A314C26" modified="2017-01-18" version="1">MRKIINSTYVSLDGVIARPNEWTFEYFNEEAQKFAYDQLFSCDALLMGRKSYEGFAASWPHMEEETGDFGVRMNTMSKYVVSTTLKDPEWKNTAVISDNVVKEIAELKERPGQDILQYGYGPVTRLLIEHGLLDELRLWIHPVIVGTGDPEELLTREGFGASFEAAETKVFTNGVIIATYRPAAKEAAEGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZXG4</accession>
    <name>A0A1H5ZXG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plsX</name>
        <name evidence="6" type="ORF">SAMN04489712_10518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40156">
        <property type="protein sequence ID" value="SEG40156"/>
        <property type="gene ID" value="SAMN04489712_10518"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG40156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="377" mass="38500" checksum="1612148BC9A99B67" modified="2017-01-18" version="1">MVPELTGRKEAGQPGRPKTDEARTVPGKRREENARWPGLSDKESGGAVLGECREEDARARPVVLDAMGGDHGPAETVRGAVTARREYGVPVLLVGRAPEVHRELLRHDAAGEIEMVHAADVVRMAERGSGAAARRESSLMVGCELVRRGAGAAFVSAGSTGAVVTCAVRVLGRELGVLRPALAVAVPSVTGGATVLVDAGATTDPTPEMVARFALLGAGYARRVLGVADPLVGLLSVGAEPGKGNRLARRAAGLLPRLPVRFHGNIEGHDVLAGTVDVVVTDGFTGNVVLKSVEGCVRATLALVADAGVAAPDRLREVARRYAAETHGGAALLGLAGTVVVAHGSSRSTAIARACVVARDLAAGRPAGACPPVGPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZZF3</accession>
    <name>A0A1H5ZZF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-formylglutathione hydrolase FrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41344">
        <property type="protein sequence ID" value="SEG41344"/>
        <property type="gene ID" value="SAMN04489712_10575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG41344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="299" mass="33236" checksum="55EF26CC4F8CE757" modified="2017-01-18" version="1">MAITREPPGLLGERRLGPRLYELAVRSAAVGRTVKMHLLVPHGWSREADRTWPLLYLFHGGDDDYRSWVRETDVDGLSAGSDVLVVIPDGGRAGGYTNWWNFDRPGAPQWETFHLEEVGRLMRETYRAGDAQALAGVSGGGYGALIYSARHPGAYRYAAAFSSPCSIRSPLVATSLLLATASVGRTNPLAMWGLPVVHDRIWRSFDPVRMAHGLRGTGLYLSAGTGRRGPLDPPDARRDMAALAEPIVRSTIGPFLRRLRELNIPITTHLYDRGTHSWPYWRRELHYAWPLIMRSLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2S5</accession>
    <name>A0A1H6A2S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma E regulatory protein, MucB/RseB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42046">
        <property type="protein sequence ID" value="SEG42046"/>
        <property type="gene ID" value="SAMN04489712_105114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038484">
        <property type="entry name" value="MucB/RseB_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG42046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="357" mass="37130" checksum="7CDB50F3A6F5894A" modified="2017-01-18" version="1">MTSAQTTPFGPSGPFGGRSAWVVGGLAAALLLAWTLAGNAGAGRRADSDPEALELLRETAAAARRTPYEGTQIRTTLTGGGHTRTAVKVAHATDTVTPLHGILVQDASSTTGGAADVTATGGLAGFTPALLALLTRNYTVVQAADDDACGRAAHVVEARRADGGTAGRFRIDAETGIMLHRELLDDGGRVVSALGFSDVRIAEPRTPAVAGASRAAPWAAVGAAEVAGLRGRGWTVPQDLPGGFVLNEVRRSGPADGGTLHLGYSDGLAAVSVFVQRGRLDERRLAGWRRSGAVFHREDSQRWAVWAADGHVYTVVTDAPRAASDTVVAALPQADTGLWGRLRRGVRRIGTWANPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A7N3</accession>
    <name>A0A1H6A7N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44738">
        <property type="protein sequence ID" value="SEG44738"/>
        <property type="gene ID" value="SAMN04489712_105268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG44738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="15484" checksum="12CB4D2B71D897DF" modified="2017-01-18" version="1">MPPRRTLKAVEPQTNDRETPNLCQAVLGALEAMTWLTESDSALIALALRYADEIEQATEQAAELERLTRDLAGDEGAYKRLKALEAKVDVTKRVGWLGPQLQGVLRDLGGTPAARKAMGADKPVGGRLAELRRGAGKGAGKYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ADQ3</accession>
    <name>A0A1H6ADQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-tubulin suppressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46909">
        <property type="protein sequence ID" value="SEG46909"/>
        <property type="gene ID" value="SAMN04489712_105390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009292594" evidence="2">
        <location>
            <begin position="35"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG46909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="444" mass="44972" checksum="02ED63290D652E5D" modified="2017-01-18" version="1">MDMHRRRTLPAALPPALAALCLLSGCSDAGPAAGDKPRVVSPPPAGTAGKVSGEVWTAGYNTDGQLGRRTAKDMDVALGPAMGLQGQGRLRGVLAMAGGGRHSLAILADHRVVAWGANDKSQLGDGTKTARAFPTPVRAPDGKPGNLSDVAAVAADADFSMALLGNGTVVTWGTGESGQRGIGRKAAPAFPTTLRRPDGRGPLTGVTAIAVNGRTGLALTKSGTVFGWGANRYGMVGDGTATDRPLPRPVRGPNGAPKLTGVRQISLGGRHALARLANGTVVAWGANNAGQLGDGTRRNHAAPTTVAGPHGLPILRNVTSVSAGANHNYALRGDGTVVAWGENVSGQLGNGSVEDSLRPVPVLGVRSSHLRGVAQIHASGTYGVAVLTDGTALTWGSGGKGQLGSGNLMPRSRPGTVVLTGGRPAGRVIGVGTGQRHLQLLMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ANH0</accession>
    <name>A0A1H6ANH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional regulator, FadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_105540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49595">
        <property type="protein sequence ID" value="SEG49595"/>
        <property type="gene ID" value="SAMN04489712_105540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG49595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="274" mass="29670" checksum="B9E59BDB07756FBD" modified="2017-01-18" version="1">MPDATPSPSSAHPAAQLAQPAIADLVAESIRDRIISGELVEGDLLPRQEEMLRELNVSRPSYREALRILEAEGLISVRRGNRGGVVVHSPSQHTTTYTLGLLLRYRQVSLGDLSDAISEIEPLCAGVAAGLPDRHEKLIPELNTLVDTQERALGEAQEFTRIGREFHEALVGGCGNMTLISTAGALAQLWSKQELEWADVVAANAAYPAVEQQRQVLQTHRMIVAAVAAGDRQQATNLARAHSLASHHHVLEGRRDLTVIHPRSSRVPGRGTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AUT8</accession>
    <name>A0A1H6AUT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52409">
        <property type="protein sequence ID" value="SEG52409"/>
        <property type="gene ID" value="SAMN04489712_10629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG52409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="588" mass="66320" checksum="61DE62509507338C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AVM7</accession>
    <name>A0A1H6AVM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_10650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52718">
        <property type="protein sequence ID" value="SEG52718"/>
        <property type="gene ID" value="SAMN04489712_10650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="180"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="240"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG52718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="458" mass="48573" checksum="D713C5EC5C04282C" modified="2017-01-18" version="1">MDVRQGPAKGRPLRRQVLVAIVGVTALAIVLFALPLAVAVQRLYRDEAITRLQRDATRVAAVVPDDINHQPRPVPRLAGLSPQLAIGVYRLDGGRLTGTGPSVSPLAAQSHDGRVHDGLERGQLAVSAPVASDGGINTVVRVSAPYDLTTDRVERTWLAMAGLAVLVIGCAALLAQYQARRLALPLERLTAAAQQLGGGDFSVHTRRSGLREADAAGLALEATARRLGAVLDRERAFSADVSHQLRTPLTGLLLGLESALERPGADLRAAIGTALERGRRLQSIIDDLLDLARDSEPAHQVLNVPALLEQARRRWHGPLAAQGRRLDIEIRRPLPQVRAAPAALSQIMDVLLDNALEHGRGRVTVRAGDVGDGLAIDVTDQGPGIPDDAPDVFARRSPRPPDGDTPSAGHGIGLALARSLAEAEGGRLVLGSPRPPVFTLLLPADDTYPDQDVHPVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWB9</accession>
    <name>A0A1H6AWB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Trigger factor</fullName>
            <shortName evidence="6">TF</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tig</name>
        <name evidence="11" type="ORF">SAMN04489712_1065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 8">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52086">
        <property type="protein sequence ID" value="SEG52086"/>
        <property type="gene ID" value="SAMN04489712_1065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG52086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="487" mass="53114" checksum="6F770742FE19826B" modified="2017-01-18" version="1">MKTDVEELTPTRVKLTVEVPFDELKPNLDRAYKEISKQVRIKGFRPGKVPAPLIDQYVGRGAVLQEAVNDALPELYGRAVEETEIFVLGQPDVEITTLDDGKELAFTAEVDVRPKFEVPDYDDLEVTVEEAAVTDEEIEETLNTLRERFGSLTAADRPAQEGDFVSIDLAAAIDGEAVEDASTTGYSYEVGSGSSVEGLDDALAGMSAGESTTFTSTLVGGERAGEQAEITVTVQSVKVKNLPEADDEFAQLASEFDTIEELRADLRTRLGRNKRMQQIGQARDKALEALLGRVDIPLPDKVVEDEIQRRNEQLEQQLQWSGLTRDAYLANEDKTAEEFDAEIAEAARQAVKGGFLLDQLALDEELGVENEELSEYVVTQAMQMGVQPQQLAQHLTDSGQIPALVSEVLRSKALNLLVEHVKITDEAGNELDLEAIQRELNGETAEAAEAGTETAEEAAETAEATEAAEAEDKAADKAEEAKDKPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWI7</accession>
    <name>A0A1H6AWI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52610">
        <property type="protein sequence ID" value="SEG52610"/>
        <property type="gene ID" value="SAMN04489712_10642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG52610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="18197" checksum="F4CBCD0C262E7814" modified="2017-01-18" version="1">MTHDQPESRRRDDDATAGLAQDLYEQVRQLNHATAGAPGLTRPSTAYTILGNLSASAYGLDQTFVQLGRFLRRELDGGRLGHDRGHHPAQAVQDACDALSEARDITTRLARSLGNAQSAINAVHGPVHPAAALAGDDFPLSVSEAVKAGPADDRSGPSPSPSTKTARSARKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B373</accession>
    <name>A0A1H6B373_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_106171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54667">
        <property type="protein sequence ID" value="SEG54667"/>
        <property type="gene ID" value="SAMN04489712_106171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293272" evidence="3">
        <location>
            <begin position="21"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG54667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="369" mass="37900" checksum="050EB33C0E0AB33B" modified="2017-01-18" version="1">MRLVAVAALLAACTITPAQAAAGPRPGVSVEPGQAAAGTSARVRGSAWTPGTTVQIQVCGANAVHGSADCDTEHGVTAMVAPTGAFEAGLTVGAPPAACPCVIRVSTLPGGAGEPVTVVTPFTVQGHRVEPVIKDVVPVRADVVGLEVVGGGERGELFGGRPRRTLVLQIRNSGPEPIENAPLVAGWGAGDTPDTPLDAPRTGILQPGQTATYRIPVELPPASFGRFVVGGRYAGSVPFETAFSTYPWGLLGVNLLAALLLLFGIRLALGRWAARRRRRRTAASSARGATSAAGAGPAHHRVAPRSSDAVEVADLIAYLDSVASSPSGAYVVDRDELIGYLEGRRGGAMEPVDIEALDRFLALPRGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BDS5</accession>
    <name>A0A1H6BDS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58938">
        <property type="protein sequence ID" value="SEG58938"/>
        <property type="gene ID" value="SAMN04489712_10734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="189"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG58938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="405" mass="43092" checksum="B5F8E8BEDC072AA8" modified="2017-01-18" version="1">MKAIVWHAVGDIRLEDVTEPKIEYPSDAVVRITGSAICGTDLHFVRGTVPGMRPGTILGHEGVGVIEELGPQVRNFFEGDRVVIASTIGCGRCVHCRAGHYAQCDVANPRGRDAGTALYGGPESTGPFDGLQAEYARVPYAHTNLVPIPPGVTDEQALMVSDIFPTGWFGARLAGVGGGDVVCVLGAGPVGQLAALSARIQGAGRVLIVDGLPDRLETARMQNAETIDFNTEDPVAVVRELTGGVGADRVIEAVGVDAQRPVGGPAAQLLDDRTAAEFEHEREQVAPHAHLHGRQWMPGDAPGQALRWAVEMVDKAGTIGIIGDYPPQYTHFPLGRAMNRNLTVQAGNCDHRRYMPGLLSRIASGGADPTTVITQQEDMPTAIEAYEAFDRHEPGWTKVVLEIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BND6</accession>
    <name>A0A1H6BND6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="5">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">truB</name>
        <name evidence="9" type="ORF">SAMN04489712_107239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61726">
        <property type="protein sequence ID" value="SEG61726"/>
        <property type="gene ID" value="SAMN04489712_107239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015225">
        <property type="entry name" value="tRNA_psdUridine_synth_fam2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09142">
        <property type="entry name" value="TruB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="6">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="8">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C" evidence="7">
        <location>
            <begin position="232"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG61726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="30005" checksum="398BF34989FA1AB0" modified="2017-01-18" version="1">MTSGLVIVDKPAEWTSHDVVARLRRLAGTRRVGHAGTLDPMATGVLVVGIDKATRLLGHLALTEKVYEATIRLGQSTNTDDAEGEITAAAPAGAVTDAELTTAIKALTGEILQVPPQVSAIKVNGQRAYKMARKGEEVELAARPVTVSEFMVTAVRRAGDLIDVDATITCSSGTYIRALARDLGAALGTGGHLTALRRTRVGPYGLDLARTLDQLAERCEVLPIGDAVAAAFPRRDVTAEQARTVAHGGRLPAAGLGPGPVGVFAPDGALLALVEEQGKVAKPLAVFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BWV0</accession>
    <name>A0A1H6BWV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein subunit 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65178">
        <property type="protein sequence ID" value="SEG65178"/>
        <property type="gene ID" value="SAMN04489712_10883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG65178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="34784" checksum="BA24FDAA4A328134" modified="2017-01-18" version="1">MSSVAERSENPLARVRDAVWRPTPASLRLLALLSVVVNAGIIVTGGAVRLTKSGLGCSTWPKCTPDSMIPTSSPDHSPMHMAIEFGNRTLTFLVLAAGIAVLVAALRSVPRRRDLVRLAAVQPFGVLAQAAWGGLTVLTDLHPAVVAGHFMLSPLLLIACVALYVRAGEGDGPARPLVSERLRALSLALAGVTALLMVAGTVVTGTGPHGGDDRSKRFGFEIEQVTRVHSALAWITVALTVALLIGLWRSGAPHSVRRPVLVLLAVELAQGVIGYVQYFLGVPELLVALHMLGSALLWIAVLRVVLATRDRGPLPAAEPVPAPARPAPQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C7D6</accession>
    <name>A0A1H6C7D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YwqG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68647">
        <property type="protein sequence ID" value="SEG68647"/>
        <property type="gene ID" value="SAMN04489712_1099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG68647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="262" mass="28918" checksum="B4689197BBA1C789" modified="2017-01-18" version="1">MDVSRVMAEIERHCVEVLGEHGGAEMAALVRRGHALVPVGDGEAPAGRSRLGGAALLESGTPWPEVEGIPLSLLAVLDTDALARWLGAELPVRPGLLNFFFLEPDLPYEEYRHLDFLGDERCRRVIAADPAFAVETSVPAPATVFDERPVTARPLLTLPGNEESVVASLDLGPGNEDKWPVMEAYNIRTTWPSDAQQEGHRAFGWPWPFQSPVMEEDEVHLLQLDSDDHFQWGDMGVLYFTIPADALRKGDFGQVRIDMHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CAI4</accession>
    <name>A0A1H6CAI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA thioester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69893">
        <property type="protein sequence ID" value="SEG69893"/>
        <property type="gene ID" value="SAMN04489712_109124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="167" mass="18594" checksum="A185C0BFEBFDAEF3" modified="2017-01-18" version="1">MTPPAGTGPNGPLATLEHKLLAVNAEYGYWETVPTRWKDNDVYGHVNNAVHYSVMDTVINAWLIREAGLDIHRSRSIGLCVESQCVYKGSIEFPEPFRVGLRVGHLGRSSVRYEVGLFREDGETPVAEGRFVHVFVDRETRRPVEIGEPMRSAMNALLTGPTEETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CBI6</accession>
    <name>A0A1H6CBI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70025">
        <property type="protein sequence ID" value="SEG70025"/>
        <property type="gene ID" value="SAMN04489712_109135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG70025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="220" mass="23843" checksum="3EE1AB32EBCC572A" modified="2017-01-18" version="1">MSERMRRPAPDNGLRATGRTDQAVGDRRRLRGAESRQAITRHAVDLASLEGLNGLSLGRLATDLGISKSGIQTLFRTRENLHLAVIETAERLFADAVVLPALDAAAGTARLRALVEHWIGYAEAPLFPGGCFWAANLADFDSRPGPVRDRLAHQHQGWVALLAEELRQAVDSGEVADLDVELAAFQIDAVLMAANTALRLGDRDAAGKVRRVVGELLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJB5</accession>
    <name>A0A1H6CJB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73074">
        <property type="protein sequence ID" value="SEG73074"/>
        <property type="gene ID" value="SAMN04489712_11068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="61"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="455" mass="49841" checksum="E5208CFCAB0D93D0" modified="2017-01-18" version="1">MAGSIDPGLLRRTAHSPSYFALARAGGGRHDELIDFCIPCNPYFPTPEMFGRLGGMLETVLKYYPSDADTITAELCGTLGLNPQTVAMGNGSTELITWIDHLLVRESLATPIPTFGRWTDQPLETGKRVDMFRLPEAHDFAFDVDAFTGFVRERGSRVAVVCNPNNPDGGYVARREVLRLLDLLVDLDLVVVDESFIDFVDAEPLTSVADEAAIRPNVIVLKSLGKNFGLHGIRFGYLVANPALAGRVRRALPKWNLNSFAEVVVFLLKEHREEYLQSLARLAADRRAMAGQLESLPGLKVFPSQGNFIMIRLPDGRDGVGLRDYLLNEHGVFVRECGNKLGGGSQFLRLVVRPQPDVHRLVTGLAAYLYGTDKARPISHLQLYEPSGHAQPAEQTASADRIPFTNQAPPTQPVRLPPPDQDPRTVCACGCGDPLSHSSATTNALLEAIYSSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQP6</accession>
    <name>A0A1H6CQP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MYXO-CTERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75339">
        <property type="protein sequence ID" value="SEG75339"/>
        <property type="gene ID" value="SAMN04489712_11121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG75339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="236" mass="24824" checksum="5440695EE5E64D5D" modified="2017-01-18" version="1">MATSESRPTAARSQQNGSAGAHQAEAKDGAQELRTDIERTRAELGETVEALASKADVKTRAKDKAGQFKENITAQAQHGIETVRDRTAPAAQKAQEKTRELAAKARETSSSEEVRAKAAPGGAAAAAGTGAAAVAVWLWRRRRARRTTRWQAAMQTAQQAGVQVRDQLRSGAAGISSASGDLMNAQVPAKVAAQARTAMSSPTTRPRVQGAAAAALVLLAAGRIRRRRARKAAMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRB4</accession>
    <name>A0A1H6CRB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75287">
        <property type="protein sequence ID" value="SEG75287"/>
        <property type="gene ID" value="SAMN04489712_11111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="97" mass="11062" checksum="29229C2FC61C6CDC" modified="2017-01-18" version="1">MSSDYPDAVVAILAESFPRLAEPAAAQAAAEAIRRHTLQPDEAFEYIVDDQEQADWRIHADRRNPGRVMLSCFRYTLTAFDYHREERVNTALAELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CT76</accession>
    <name>A0A1H6CT76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75873">
        <property type="protein sequence ID" value="SEG75873"/>
        <property type="gene ID" value="SAMN04489712_11193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="135" mass="15073" checksum="D2247B87A7CCA9C5" modified="2017-01-18" version="1">MTVGRLAARAGVRTDTIRYYERAGLLPSPQRTSGEHRRYDERALDRLLFIRGAQRLGLRLSEIRRLLEVRDTGVCACEPAATLLHRHVSEIDAEMNRLAALRGELTRMLAAMPGPDCPDPVPGTWCPPALETEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CW12</accession>
    <name>A0A1H6CW12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized domain 1-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_111266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG77221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG77221">
        <property type="protein sequence ID" value="SEG77221"/>
        <property type="gene ID" value="SAMN04489712_111266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG77221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="17450" checksum="CD9C67D10DC81952" modified="2017-01-18" version="1">MSETSEARSRTVRWEDPDAGLMKALSMEGIDAVNAILKGELPAAPMSRLLGIRGVEAEKGRVVVALEPAEYHSNGTGGVHGGLAASLIDSAAWLALHTEMPAGAFCSTLQLNIHYVRPLRIGGGEVFAEGRVLHCGRTAATAEASITDDRGKVLAHGTTHCTVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CYS7</accession>
    <name>A0A1H6CYS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase (Flavoprotein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78289">
        <property type="protein sequence ID" value="SEG78289"/>
        <property type="gene ID" value="SAMN04489712_11258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="35659" checksum="2B79B69B68ED13FF" modified="2017-01-18" version="1">MSGGHDLLVVGGGPAGLATALHAVRAGFDVVVAEPRRTPVDKACGEGLMPGAVRALHALGVPVPGHPITGIRYVQGACHVQAAFRRSPGLGVRRTGLHAALHQAVIDAGVPVLPVRVGEIRQDATGVTAVGAGLRARWLAAADGLHSPIRRALGLEAATRGTPRYGLRRHYAVPPRSSCVEVHWGPCGEAYVTPLGPALVGVALLTTQRSPFDTQLTAFPGLAARFPAEAALTAVRGAGPLRQSARTRVHGRVLLVGDAAGYIDALTGEGISLALAGAEALVGNLRRGTPGNYETDWRNATRRYRLLTEGLIRARRHPALGHRIVPLAERLPGVFAAAVNALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D728</accession>
    <name>A0A1H6D728_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase HrpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_11367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80356">
        <property type="protein sequence ID" value="SEG80356"/>
        <property type="gene ID" value="SAMN04489712_11367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010225">
        <property type="entry name" value="HrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005496">
        <property type="entry name" value="ATP_hel_hrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01970">
        <property type="entry name" value="DEAH_box_HrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="216"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG80356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="851" mass="90305" checksum="AFF5BA0C49E10B6D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8W8</accession>
    <name>A0A1H6D8W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine/homoserine efflux transporter RhtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_114110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81659">
        <property type="protein sequence ID" value="SEG81659"/>
        <property type="gene ID" value="SAMN04489712_114110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="154"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG81659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="324" mass="32570" checksum="FB3E7F4A2E00FDAD" modified="2017-01-18" version="1">MTGAKSWGLVLALVSSVCFGASGPFGKALIGAGLDPLQAVWVRVTGAALVLVPLVLAVRGRRALAAAGPYWPQLAAYGAVAIAACQALYFVAASRLPVGIAILLEFTGPVLVLAWIWLVRRTRVHPGAAAGVGVAMAGLAIVVEIWSGMSLDPLGLVAGLGAAACQAAYFLLVERLTGQVDPLVMTAAGTVVGAALLTGLASPWALPWHVLGDGVAVGEHTAPGWLLAAWIIVVSTVLAYLTGVAAVQRLSAQVAGGICYVEAVAATLIAWAALGERLTAPQLIGGAIVLTGAFLAQRAASAPSRPPVTAPPALPTVADAALTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D8Y8</accession>
    <name>A0A1H6D8Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81303">
        <property type="protein sequence ID" value="SEG81303"/>
        <property type="gene ID" value="SAMN04489712_11421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28897" checksum="04D8746762092B47" modified="2017-01-18" version="1">MTPVVVQRNGRAATAEELAPLAFAGYAHFTAMQVRGGKVRGLDLHLERLRFASVELFGRALPDDRVRSYLRAALEAGPADISLTATVYSSPGEFTAGGDDVEPEVLIRTGPPASGPAGPLTLATVEYERVLPAVKHVGEVAKTYFMRRAVREGFDDAAFVDRRGRLSEGTIWNLAFWDGSAVVWPDAEMLVGTTMGIVRRQLDRLGVPQRVQEITPADLPTLAGAVVMNSWTPGVAVHRIGSAPVPEAPRFLELLHQAYQAEPLTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9X7</accession>
    <name>A0A1H6D9X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81495">
        <property type="protein sequence ID" value="SEG81495"/>
        <property type="gene ID" value="SAMN04489712_11470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="142" mass="15478" checksum="44287FB600BFFF18" modified="2017-01-18" version="1">MPLGRRVSKDVMERYAADQELAGTYRARLDAAAEAEEAYRRARAAEAAHPGQGLRDLAIALDKALTEALLAAEAAERVAMGPKTYAPEDAKDSGRARRDAEIARRKAKARPAVRPWTDEVDRLRTAREAHRLGHRVGPGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAE2</accession>
    <name>A0A1H6DAE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine-5'-phosphate glycosidase</fullName>
            <shortName evidence="6">PsiMP glycosidase</shortName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psuG</name>
        <name evidence="7" type="ORF">SAMN04489712_114115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-ribose 5-phosphate + uracil = H2O + psi-UMP</text>
            <dbReference type="Rhea" id="RHEA:18337"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="4.2.1.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the pseudouridine-5'-phosphate glycosidase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81675">
        <property type="protein sequence ID" value="SEG81675"/>
        <property type="gene ID" value="SAMN04489712_114115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046113">
        <property type="term" value="P:nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="PTHR42909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="SSF110581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG81675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="31818" checksum="0E2863565A7C585D" modified="2017-01-18" version="1">MPEPLLRLSPEVADALEGRSPVVALESTIISHGLPRPRNLEVARELEELVRAGGAVPATIAVLDGVAHVGLDDAALERVACDPDLRKLGYRDLPPAAATGAGGATTVSATAFLAARAGIRVFATGGLGGVHRGWADSWDESADLALLSRTRITVVCAGVKSILDVPATLQRLETLNVTVAGYRTSTFPGFYLHSSGEPVDWTLTEPEQVAAAMRAQDALDGPAAALVVANPVPVERQLDPGLHDRVLGEALAAAERQAVTGQATTPFLLDYLVRGTGGASLEANLAAVRGNVALAAEIARCWAAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAN7</accession>
    <name>A0A1H6DAN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4158 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_114142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81785">
        <property type="protein sequence ID" value="SEG81785"/>
        <property type="gene ID" value="SAMN04489712_114142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025296">
        <property type="entry name" value="DUF4158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13700">
        <property type="entry name" value="DUF4158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4158" evidence="1">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG81785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="223" mass="26046" checksum="57DD13697ED41605" modified="2017-01-18" version="1">MPVEFLTDEQAEAYGAFTEVPTRPELERFFFLDDDDRDLIALRRTDAHRLGMAVQICTVRYIGRFLDEDPLAVPWEAVEYLAGQLGIADASCVKRYPERRRTPYEHAAEIQERFKYRDFTDRRWGREFRGFLYGRAWTHAEGPVALFNHAVTWLRKNRVLLPGVPVLARQVSEARTAAERRLYEAVTRAAHRADPALARRWLSCWWCRRAGGSRSWSGCARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DC56</accession>
    <name>A0A1H6DC56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative peptidoglycan lipid II flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_115133</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83057">
        <property type="protein sequence ID" value="SEG83057"/>
        <property type="gene ID" value="SAMN04489712_115133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG83057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="527" mass="55776" checksum="2FF321C2005A4A54" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEK3</accession>
    <name>A0A1H6DEK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar lactone lactonase YvrE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83857">
        <property type="protein sequence ID" value="SEG83857"/>
        <property type="gene ID" value="SAMN04489712_11683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="35"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="535" mass="55276" checksum="7D668054458419DD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEX0</accession>
    <name>A0A1H6DEX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83774">
        <property type="protein sequence ID" value="SEG83774"/>
        <property type="gene ID" value="SAMN04489712_11665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="168"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="313" mass="33423" checksum="B19F0E46D6D9E493" modified="2017-01-18" version="1">MNIELSEAAAEYGRQALRALRAAGGDRLVQLAEREPGRREDLVAPVLRELGAWDLDPRGDADDLEAAAALCRSAGYWAVAYPVAERLARPADLDVDGLVVVADSAPKGAVAGLGLRWVAVTLDGRRGDAVARTPNVPPRTSAFVTDLDVRPLDEAGAGDVALGLVLPCWTLLGMLDRAIELTRSHVLARHQFGGPLAERQGVQFQLTDAEVERSGAEALAKYALWSVQAGLAEALDDALALRLAALEAAETVFRTAHLLHGAIGFCDETTLSWVSRYSQPVRRLPLGLSATRDRLTRQIGRRGLTGLFPGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFA9</accession>
    <name>A0A1H6DFA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_116100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83914">
        <property type="protein sequence ID" value="SEG83914"/>
        <property type="gene ID" value="SAMN04489712_116100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="106" mass="11902" checksum="4DDE7B5F2B58A1B9" modified="2017-01-18" version="1">MPKGVMVIQTSPSDPSREDEFNEWYSNTHLPEVCEVPGIVAARRYRVLDDTDPARHSYLAIYELEADDLTATLKELRARTASGQIGLSDTLRLDPPPSIAIYELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DI69</accession>
    <name>A0A1H6DI69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-hydroxycyclohexanecarboxyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_117150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85157">
        <property type="protein sequence ID" value="SEG85157"/>
        <property type="gene ID" value="SAMN04489712_117150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="237" mass="24862" checksum="C2B73746087D683E" modified="2017-01-18" version="1">MVVRNAVVTGGASGIGRAIAQRLSADGHRVAVLDLNPPAGDESAFKADVTDRGQVDEALAAVRERLGPVTILVNAAGLDGFKRFTDLSFEAWQRVIDVNLNGVFHCVQAALPDMLEAGWGRIVNISSSSAHSGQPFMTHYVAAKSAVNGLTKALALELGPKGITVNAVPPGFIDTPMLRKAEERGLLGGTVEDHIARTPVRRIGRPEDLAATCSFLASEDAGYITGQIIGVNGGRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKA2</accession>
    <name>A0A1H6DKA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coenzyme PQQ synthesis protein D (PqqD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85541">
        <property type="protein sequence ID" value="SEG85541"/>
        <property type="gene ID" value="SAMN04489712_11828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="83" mass="9042" checksum="92C8402302803C17" modified="2017-01-18" version="1">MNLSPDVIVTETDTGTVLLDERTGRYWTLNPTGGAVLRLLVDGRTPEEAAGELARRHPAFADRIAQDVRALVGSLLEEKVMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNM4</accession>
    <name>A0A1H6DNM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="6" type="ORF">SAMN04489712_12015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86838">
        <property type="protein sequence ID" value="SEG86838"/>
        <property type="gene ID" value="SAMN04489712_12015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG86838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="104" mass="11357" checksum="10498D586F775956" modified="2017-01-18" version="1">MYAIVRAGGRQEKVTTGDVLTVDKLGDEVGATVTFPAVLVVDGDNVVTSPAELAKYEITAEVLGAVKGPKINIMHYRNKTGYKRRMGHRQPYTRVKVLEIKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPG3</accession>
    <name>A0A1H6DPG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_119105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86536">
        <property type="protein sequence ID" value="SEG86536"/>
        <property type="gene ID" value="SAMN04489712_119105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="84"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="358"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG86536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="527" mass="56865" checksum="F2D8AB79488427A4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQX8</accession>
    <name>A0A1H6DQX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87817">
        <property type="protein sequence ID" value="SEG87817"/>
        <property type="gene ID" value="SAMN04489712_1218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG87817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="324" mass="31900" checksum="1F6CE05D2C23D72B" modified="2017-01-18" version="1">MTALTALKGQARLALPPGVSRHAGLLTVLLAIGTVTALKSDAFLTGSNLLNVSQQIAVVAVLAAGLTLLMTAGGIDFSLGAIAALAHGVVAQLIVAGFNEWTAVGLALALGAAIGLVNGLVVTLLKVVPFVATLATSTILGGAALLVIDGKSISIGEHLVSLGFGEVAGAVPALVVIAMVVCVAAGLVLRWTAFGRNAFAIGGNENAARLAGIPVVRTKLLLYTLGGLLAALGGVMLVARLGAASPGTGGLHLELTVVAAVVIGGTALHGGSGTLVGTVLGVVLLGVVANSLNLLQINAHYQDVALGTVLLIAAITNHLRGGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRJ2</accession>
    <name>A0A1H6DRJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">kdpB</name>
        <name evidence="15" type="ORF">SAMN04489712_12130</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87899">
        <property type="protein sequence ID" value="SEG87899"/>
        <property type="gene ID" value="SAMN04489712_12130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="408"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEG87899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="725" mass="75907" checksum="84FFA370E985EBE5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DRL1</accession>
    <name>A0A1H6DRL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87860">
        <property type="protein sequence ID" value="SEG87860"/>
        <property type="gene ID" value="SAMN04489712_12120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="27759" checksum="6DBDAFA8CB2E482C" modified="2017-01-18" version="1">MANSSIPGAGPRPVNVRYAETWLQMHGLGDGSPTPLLTARLAVRQRVRLLGSVLQAVLILGAALALAFGGSGSHRPTPVLALSALVVALVLARTLLDAWIRRVDRQAGAALARRAAHPVQLGWRALLGRPYAVLVASTFAGAFALGASALAVGEGTARYAAVVVLVAVVGVGIGEALQLRELLARPVVAEDEVSLMADVIMRIEDARDGTMPTVLWSLPMVLLFGSAPGWWNAASIGFVVLGMVAYITVQFRAPGAAAVAREVVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSA2</accession>
    <name>A0A1H6DSA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87944">
        <property type="protein sequence ID" value="SEG87944"/>
        <property type="gene ID" value="SAMN04489712_12142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="566" mass="60980" checksum="F51D29C19BCF5F53" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTM3</accession>
    <name>A0A1H6DTM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88697">
        <property type="protein sequence ID" value="SEG88697"/>
        <property type="gene ID" value="SAMN04489712_12261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="434"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG88697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="526" mass="55458" checksum="764268E1286AF6AF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU54</accession>
    <name>A0A1H6DU54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Maleate isomerase</fullName>
            <ecNumber evidence="1">5.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Maleate cis-trans isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">maiA</name>
        <name evidence="2" type="ORF">SAMN04489712_12276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>maleate = fumarate</text>
            <dbReference type="Rhea" id="RHEA:13169"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
            <dbReference type="EC" id="5.2.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction is initiated by nucleophilic attack of cysteine at the double bond, yielding a covalent succinylcysteine-like intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the maleate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.1" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88769">
        <property type="protein sequence ID" value="SEG88769"/>
        <property type="gene ID" value="SAMN04489712_12276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050076">
        <property type="term" value="F:maleate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00943">
        <property type="entry name" value="Maleate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028615">
        <property type="entry name" value="Maleate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="S-(2-succinyl)cysteine" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="245" mass="26533" checksum="F7A0E4A02F102873" modified="2017-01-18" version="1">MTALRFGMIVPSSNTTMETEIPAMLRAREQIAPERFTFHSARMRMQHVDPEQLRAMDDQSVACAEQLADADVDVMAYACLVAIMAHSPGYHRISQERLSKAAGRAPVLTSAGALVEALEHLGAKKISVITPYMKPLTQTVCEYIQAEGVEVQDAVSLEVSDNLAVGRLDPQNLPEIAAKVDTSGVDALVLSACVQMPSLPVVQQIQDSFDIPVVTASIATVWRTLRELGLEPVVPNAGWLLADRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUP5</accession>
    <name>A0A1H6DUP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88473">
        <property type="protein sequence ID" value="SEG88473"/>
        <property type="gene ID" value="SAMN04489712_12210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="45" mass="4838" checksum="0E65FED866FD7D69" modified="2017-01-18" version="1">MTTHDEDERSGEPDVQLAAELIERAGAEGVSLENITVTPWTALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVV0</accession>
    <name>A0A1H6DVV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase components of ABC transporters with duplicated ATPase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89430">
        <property type="protein sequence ID" value="SEG89430"/>
        <property type="gene ID" value="SAMN04489712_12391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG89430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="538" mass="57695" checksum="71D56697D9FAB5C5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYE7</accession>
    <name>A0A1H6DYE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Act minimal PKS acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90347">
        <property type="protein sequence ID" value="SEG90347"/>
        <property type="gene ID" value="SAMN04489712_1269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG90347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="86" mass="9307" checksum="017A44E5B2BABA6D" modified="2017-01-18" version="1">MPRSQFTLDELRTVLREAAGTDEGVDLDGDIIDVSFDALGYESLALLETASRIERDHGISLDEEALVAAKTPRELIDLVNAHLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZS8</accession>
    <name>A0A1H6DZS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90165">
        <property type="protein sequence ID" value="SEG90165"/>
        <property type="gene ID" value="SAMN04489712_12557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="50" mass="5377" checksum="3D61D9A9CA86C17F" modified="2017-01-18" version="1">MTIDAGDAVSQPAPPDPQEVEPRFHLYETAARAEEILPLNAEGLGCSNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E122</accession>
    <name>A0A1H6E122_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91111">
        <property type="protein sequence ID" value="SEG91111"/>
        <property type="gene ID" value="SAMN04489712_12839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="139" mass="14350" checksum="CE35CE50E20F5CF4" modified="2017-01-18" version="1">MTSLRSVTDGGLFTDGRRLLRAALRIDAVITGVNGLAYLALAGPLESLLGLPTGPGRAIGALLLVYAVAVWAVSMPDRIGRGAAMAVVEANLLWTVLSIVAVATGRPELNVAGGVWAVLQALVVAGFAALQYTALRQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1B0</accession>
    <name>A0A1H6E1B0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_12738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90786">
        <property type="protein sequence ID" value="SEG90786"/>
        <property type="gene ID" value="SAMN04489712_12738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="28"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG90786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="290" mass="30843" checksum="CD303A56D7D60DA8" modified="2017-01-18" version="1">MGLDGGVNESPFTDLGRPPLNEQALNRMLVRSGSLWRRIEVVAETGSTNADLAEAARRDAPEGQVLVAEAQTAGRGRLGRSWTAPPRSGLMFSVLLRPRVDPAALGWLPLLTGLATATALRRVTGRAASGDFGRPGGSGLDVRLKWPNDLLVGERKLAGILAEKVADAVVVGVGLNVSLRTDELPVPTATSLACEDATFQEREALLRAVLRELETWYREWTALKGDPETSGLRTAYKDLCATLGRRVRVLLPGDRTLTGEAVDIDAAGCLVVATPEGDQVVGAGDVVHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1W0</accession>
    <name>A0A1H6E1W0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91163">
        <property type="protein sequence ID" value="SEG91163"/>
        <property type="gene ID" value="SAMN04489712_12851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="65" mass="7001" checksum="C8ED3895A8B913C9" modified="2017-01-18" version="1">MTQEALSRAVWRKSSHSGNGGNCVEIADLSTGIAIRDSKNPDGPRIVLPLTQWTALVHTIKDSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E1W7</accession>
    <name>A0A1H6E1W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG90996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90996">
        <property type="protein sequence ID" value="SEG90996"/>
        <property type="gene ID" value="SAMN04489712_12810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025048">
        <property type="entry name" value="DUF3987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13148">
        <property type="entry name" value="DUF3987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="525" mass="56387" checksum="B3CB7BE4766B8601" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E417</accession>
    <name>A0A1H6E417_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91774">
        <property type="protein sequence ID" value="SEG91774"/>
        <property type="gene ID" value="SAMN04489712_13047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038965">
        <property type="entry name" value="InsF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46889:SF1">
        <property type="entry name" value="PTHR46889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="2">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="127"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="203" mass="22488" checksum="C5A723B12B7386D1" modified="2017-01-18" version="1">MSRLRFVADHRALFGVKRLCRVLGVSRSGLYRWQATADARAERVRADTELAAQITEVHAAFDGTYGSPRVTAELRGQGLRINHKRVERVMRCFGIVGVHLRRKVRTTVPEPDAAPVPDLLRREFTAPAPNRKYVGDITYLPIAGGEFLYLATVLDLGSRRLAGWSIADHMRTELVIDALQAAAATRGGNLDGVSFPPLHGHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E440</accession>
    <name>A0A1H6E440_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92347">
        <property type="protein sequence ID" value="SEG92347"/>
        <property type="gene ID" value="SAMN04489712_13323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="970" mass="106013" checksum="020AD9D097C04145" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6M6</accession>
    <name>A0A1H6E6M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mutator mutT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000034">
        <property type="protein sequence ID" value="SEG92604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92604">
        <property type="protein sequence ID" value="SEG92604"/>
        <property type="gene ID" value="SAMN04489712_13446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="41"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG92604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="216" mass="23024" checksum="7B7E69B6B26C62ED" modified="2017-01-18" version="1">MSEPLDGPPDDPLTSLTAFTDLARERLAAHDHTVLDGGPGVRRAAVALCVVEHEGAPSVIVIKRAARGRNAGQWGLPGGGVDAGETAEQAALRELHEEIGLSAGPADVLGRLDDFPAASGFVITPLVLMPADPGPLRPSPDEVHSVHHVGLRRLAADDAVRWVPQLDGGRLLQMTLGPRMVIHAPTGAMLWQFREVVLLGRAARVADFLQPDWTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E770</accession>
    <name>A0A1H6E770_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type branched-chain amino acid transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93507">
        <property type="protein sequence ID" value="SEG93507"/>
        <property type="gene ID" value="SAMN04489712_13918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296601" evidence="1">
        <location>
            <begin position="28"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="57"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="436" mass="46253" checksum="0C4963896E60C670" modified="2017-01-18" version="1">MTPRPKLMLAAALGAAGLLTTACGGSAVSDSSNASGQGSGLARGCPDNGTTGLTDTTIKLGLSQPLSGPYVSVGGQLYGMQAYFAYVNSQGGIQGPDGRKRKVELVYKDDAYTATKAKANVDQLVNRDKVFALLGQFGTAGNLAARPIIAQQCVPSLFATTGAPELANPKYPWAIAGSISYATEGRILGQYVRDKHPNATVAVLEQDDDLGRAYLQGFEQAIAGSGVKVVATQTFEAGEPDVKNQITTLAATKADLYFNVASGLTGLQALNHVHASGWRPEVIQVAQLPVTLLRRLQPGAGDRLITGGTGPDFANPEVAAGNEEFQLYMQWFRKTPGADKIDPLSASQGWFQGRLLDWTVRHATTMDRVGVMESARSIDYTGPSFTLPGIKIHTTPDDPHLFEGMQLNRFDAAKGRLVPLGEVIDIDGQVKYEPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7G1</accession>
    <name>A0A1H6E7G1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plsX</name>
        <name evidence="6" type="ORF">SAMN04489712_13740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93193">
        <property type="protein sequence ID" value="SEG93193"/>
        <property type="gene ID" value="SAMN04489712_13740"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG93193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="376" mass="39436" checksum="B806AB038B867F45" modified="2017-01-18" version="1">MTGDDTGAPARPVAIDTMGGDHAPEEIIAGAVTAVREHGVRLVLVGQAPRVRAELDRHGVTREIPIVHAEETLAMDEGALASWRKPRSSVAVACHLIKTGRASALVSAGTTAGVVATSRLRLKAQQGVLRPAIAVTLPTRPRPTVLLDSGATADVKPEALVQFAALGTAYAQVALGVERPRVGLLTIGAEPGKGNKVVRRAHELLAGGQHGIEFAGNVEGDDLLTGAVDVVVTDGFTGNVALKTMEGAARMAMAELQETLRSSTTAKMGALLQRRRLQALRDRLSSETYGGGVLLGLNGTVVIAHGASRARAITSACLLAHELAAGHIVERIRDQIAATRTSRFVLRLGEKADKEAKEAKEHRTEQEPPARPEPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7U2</accession>
    <name>A0A1H6E7U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93323">
        <property type="protein sequence ID" value="SEG93323"/>
        <property type="gene ID" value="SAMN04489712_13820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="77" mass="8623" checksum="753CB93926CD9C37" modified="2017-01-18" version="1">MTQDASQPTNGHQGTTPDRAYPVRRGDRIDYRFTDGLLTEVADVLAARGYPTIDPNGGDHEELAFALWNFIYGRPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8A9</accession>
    <name>A0A1H6E8A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93186">
        <property type="protein sequence ID" value="SEG93186"/>
        <property type="gene ID" value="SAMN04489712_13738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296629" evidence="2">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="15693" checksum="A3C5858D944AF9E4" modified="2017-01-18" version="1">MTIRPFPACAALAGLALLLSGCSVTRTISAGAYRTAVADGTVAELRRLGITAERRPQCHMPDTGSPTVVRITCTGRTVTGQPIGVRGVVTAADTSRPDEHYVITVAGREVLRKSCLGLGCTAQHTPVHQHEPRYENGQVPEKPARHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8F5</accession>
    <name>A0A1H6E8F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH:flavin oxidoreductase / NADH oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000042">
        <property type="protein sequence ID" value="SEG94010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94010">
        <property type="protein sequence ID" value="SEG94010"/>
        <property type="gene ID" value="SAMN04489712_14225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="18962" checksum="9F6CBEAB7C2C22DE" modified="2017-01-18" version="1">MSAPDVFAPARLGPLTLRNRIIKAATFEHMAPGALVSDDLIEFHRAHAAGGVGMTTVAYCAVAPEGRTERNQIWMRPEALEGLRRLTEAVHAEGAAVSAQIGHAGPVANGKSNGLPALAPTATFSPLSMQRIRRATAADIERITKAHADAALMAAEAGFDLPADHQGQPAVVTRRGHRGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8V1</accession>
    <name>A0A1H6E8V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase conserved C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94127">
        <property type="protein sequence ID" value="SEG94127"/>
        <property type="gene ID" value="SAMN04489712_14317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="751"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116251" checksum="390503FEC7E6ADED" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E907</accession>
    <name>A0A1H6E907_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase and inactivated derivatives, TnpA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_1442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000044">
        <property type="protein sequence ID" value="SEG94192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94192">
        <property type="protein sequence ID" value="SEG94192"/>
        <property type="gene ID" value="SAMN04489712_1442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002513">
        <property type="entry name" value="Tn3_Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01526">
        <property type="entry name" value="DDE_Tnp_Tn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DDE_Tnp_Tn3" evidence="6">
        <location>
            <begin position="236"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG94192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="653" mass="72065" checksum="5C00D948D5F27EDB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9B5</accession>
    <name>A0A1H6E9B5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queE</name>
        <name evidence="7" type="ORF">SAMN04489712_1418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93851">
        <property type="protein sequence ID" value="SEG93851"/>
        <property type="gene ID" value="SAMN04489712_1418"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="22"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="41"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG93851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="25584" checksum="BE6EF72EB21104A7" modified="2017-01-18" version="1">MSGKELLVSEIFGPTFQGEGPSAGVRAAFLRLSRCPLACRWCDTPYTWDTSRYDLTTETRRMSEEEVLADLLARPAPLVVITGGEPLLQQDRLTWLIDMCRARRRRVEVETSGTVVPSRGVLGAAHRFNVSPKLANSGMPQHRRINPDALRAFTRSGKAAFKFVVEGLADLEEIAELEAEYGLAPIWVMPQATTAEGVLDGLRTVADEVLARGWNLTGRLHVLLWGDVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EAS3</accession>
    <name>A0A1H6EAS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94341">
        <property type="protein sequence ID" value="SEG94341"/>
        <property type="gene ID" value="SAMN04489712_14620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="138" mass="15769" checksum="A9C1264DC7F1A20C" modified="2017-01-18" version="1">MISCVLQDGDPRGYGRYALTETEHGQVLGVCAEVEGLFREPQRGMYEMVGWLPEELPEGVRRWVGDRVWLVPVDEALGPWLLEDAVVRRRQVRLTYSGRERVVAIATSTHRNDDYSALLFTWSHGPELRAYLAANRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBR8</accession>
    <name>A0A1H6EBR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_15020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000050">
        <property type="protein sequence ID" value="SEG94721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94721">
        <property type="protein sequence ID" value="SEG94721"/>
        <property type="gene ID" value="SAMN04489712_15020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="62" mass="7254" checksum="60284B50379B7ECE" modified="2017-01-18" version="1">MASRLQASCPGWLVMWSPWRRKFTAFACLMPESMIIDESTAELLIEQIHRMEMRSVIPAGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S0W0</accession>
    <name>A0A1H5S0W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MinD-like ATPase involved in chromosome partitioning or flagellar assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44004">
        <property type="protein sequence ID" value="SEF44004"/>
        <property type="gene ID" value="SAMN04489712_10127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="105"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF44004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="35863" checksum="86D7DE06E1A32034" modified="2017-01-18" version="1">MEGVPPSFGATSDPVAPVTDVRPPQPSPRQPVARPPDSEPVPPVKPAAAPSISPDELVARPVHGDSLLRRIGRGAVRPFVPAGDVQALAEHGRWIQHPVTTGRRIAVTSLYGGAGKSTLAALIASVFARYRQDRVLALDLDPELGSLPLRLGIGAEHALADLVDAEPGTASFEQIQPYLAHLGGRLWGLAGTHGVPGGPDAALYRAAGIPLSRFFGVTVTDCGAGIHTELHRVVLAAAHAQVLVAPTTGGAAGVGRVLDWMSANGLDGLAERTLVVFTVQSPHNDRLVDVPRAAQILAEVGVGAIKLGYDRHVAVGATLDPARLAYATRVTAIAVAAEALRRSLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SAN5</accession>
    <name>A0A1H5SAN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reductase C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF47649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF47649">
        <property type="protein sequence ID" value="SEF47649"/>
        <property type="gene ID" value="SAMN04489712_101138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="309"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF47649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="41447" checksum="BAAEC12EC544D674" modified="2017-01-18" version="1">MDHVIVVGGGLAGVRSVEALRAKGYEGGLTLVSAEPHRPYDRPPLSKAVLTGDSDDTTVDADWAALRCELLLGERATGLRPADGGGGTVTTTAGDLPFDGLMIATGATPITLPGDGPQRVLRTIDDARRLRAGLREGARIVIVGAGWIGAEVATAAARKGCAVTVVEAADAPLANAIGPEVGAHTAPWYAEAGVELRTGVKVAAVEHGGLTLADGGRIDADEVVVGVGVRPETGWLEGSGLEVAGGVVTDAALRTNRPGIVAVGDCAAWWSRRYGRRMLVEHWDTALNAPEVAAATLLGQEAVYDAVPYFWSEQFGRMVQYAGHHPVAERMVRRGDPGDPKWAVCWLTGDRLEAVLTVDRPRDLVQARRIIAAGDRVDAVALADPEIPLRKTLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SCB9</accession>
    <name>A0A1H5SCB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_SAV_6107 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48175">
        <property type="protein sequence ID" value="SEF48175"/>
        <property type="gene ID" value="SAMN04489712_101152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040891">
        <property type="entry name" value="HEPN_SAV_6107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18726">
        <property type="entry name" value="HEPN_SAV_6107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_SAV_6107" evidence="1">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF48175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="123" mass="13136" checksum="E7174A8EADD42721" modified="2017-01-18" version="1">MCLAEAAEATSPAVRYVSAHLAALRAAAAVLATREPLETHRRGRPRSVWVLLPEADPALREWAAFFAAGADKRAAAEAGLPRAVTPREAEELMHDAEIFVSLVEDTLGVPSQPTLPMPETRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SD83</accession>
    <name>A0A1H5SD83_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">SAMN04489712_101158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF48374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF48374">
        <property type="protein sequence ID" value="SEF48374"/>
        <property type="gene ID" value="SAMN04489712_101158"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="49"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF48374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="429" mass="45176" checksum="E7EAE1B1141F3647" modified="2017-01-18" version="1">MSGTYVIKGARILGGEPADLLLRDGEIAETGRGLAAAGAEVIDADGLVALPGLVDLHTHLREPGREDAETVESGTRAAARGGYTAVHAMANTHPVADTAGVVEQVWRLGREAGFCDVHPVGAVTQGIAGRQLAELGAMADSAAQVRVFSDDGHCVSDAVIMRRALEYVKAFDGVIAQHAQEPRLTEGAQMNEGEVSAALGLPGWPAVAEEAIIARDCLLAAHVGSRLHVCHVSTAGSVEIIRWAKSKGWRVTAEVTPHHLLLDDAVVRGYDPIYKVNPPLRTVDDVTALRHALADGTIDAVATDHAPHPVEAKETEWAAAAMGMIGLETALSVVQQSMIETGLLDWPGVADRMSYRPARIGRLNGQGRPLEAGAPANVVLYDPAPRTVVDPSGFASKSRNSPFAGLELPGRVVATFLRGRPTVLEGKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5STX6</accession>
    <name>A0A1H5STX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate synthase (NADPH/NADH) small chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53418">
        <property type="protein sequence ID" value="SEF53418"/>
        <property type="gene ID" value="SAMN04489712_101342"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF53418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="487" mass="53003" checksum="13A7DEF711D3D91A" modified="2017-01-18" version="1">MADPKGFLTVPRELPERRPVDVRIKSWSEVYESFGRDRLEKQASRCMDCGIPFCHQGCPLGNLIPEWNDLVYRTDWREAVERLHATNNFPEFTGKLCPAPCETACVLGINSDPVTIKRVEAEIIDRAWAEGWVAPRPPAVRTGRKVAVVGSGPAGLAAAQQLTRAGHEVTVYERDDRIGGLLRYGIPEFKMEKRHLERRLEQMRAEGTEFKTSVNVGVDVTAEQLRERYDVVLLAGGATVRRDLPVPGRDLAGVYQAMEYLPDANRVQEGDYAEPKITAAGKHVVVIGGGDTGADCIGTAIRQGAASVTQLEIMPRPPQTRPDSQPWPTYPMLYKMESAHEELAGLGGERLYALNTVEFLGDEDGNVRALKVVGVEGPQTGFKPIPGTERELPAQLVTLAMGFLGPQREGLLEQLGVELDQRGNVVRDASYATSVDGVFAAGDMGRGQSLIVWAIAEGRAAAAGVDAYLSGTTALPYPIPPTARPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SZH7</accession>
    <name>A0A1H5SZH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF55950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF55950">
        <property type="protein sequence ID" value="SEF55950"/>
        <property type="gene ID" value="SAMN04489712_101424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF55950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="27356" checksum="AF70301B016F4CC6" modified="2017-01-18" version="1">MLLRDRVVVISGVGPGLGRGLALRCAAAGADVVLGARTEARLAEVAKEVAGLGRRAVTVRADITDEASCRGLAEAALESFGRVDGLVNNAFAIPPLTDLGSVDLDAVRAGLETNVLGTLRLTRLLTPALTEHAGSVVMINSAVLRHSRRTFGAYKMAKSALLALAQSLATELGPQGVRVNTVAPGYIWADNLKWYFDHLAKKRGVTAQQVYDETAATTDLRRLPEPDEVADAVVFLLSPLARAVTGQCLDVNCGEWHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TDX8</accession>
    <name>A0A1H5TDX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF60964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF60964">
        <property type="protein sequence ID" value="SEF60964"/>
        <property type="gene ID" value="SAMN04489712_101580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF60964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="267" mass="28781" checksum="4AB17511B98225DE" modified="2017-01-18" version="1">MADALRLYALLIWTWIRAAAQFPVSMVLLGLASAAVAALDMVGIMLLFAHTPRIAGFTAPEVLFLYGTSAMSFVVADVLLGGTERLGEHVRQGTLDTMLVRPVSPLIQIATEDFSPRRMAKLLPPVVVLAFVLPRLPADWTAGRVVMVPVMLVSGTVIFAALWVLTASVQFVVIDVHAATKSVTYGGAFLTQYPMSLYARDFVRGMTFTIPLAFVNWQPALYVLDRPDPLGLPAALRFAAPAVAVALCAVAALAWRAGLRHYRSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TJN4</accession>
    <name>A0A1H5TJN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62973">
        <property type="protein sequence ID" value="SEF62973"/>
        <property type="gene ID" value="SAMN04489712_101645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009285096" evidence="2">
        <location>
            <begin position="38"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF62973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="331" mass="35339" checksum="490C24254DF1DB9A" modified="2017-01-18" version="1">MTDVKTGMTRRLRAALLVALLAGALAAGAVQGTPASASAHSRAGGPDVLPSLRPHLVMYYDFDHPVPGDPARERDRGRSGTDLDLVNGGAAMRVKDHAHRGSRSALQTRQVDPQVAGNDDWKAGVYSATGVPTLRAFNGARQITVMGWFKRTGEGPAPNSGTADPGDRYNAIGLAGVLTGDSDGHGVRALLEIINVGGELRVVALGRRVDGGASQTFAADEDWRSILPIGRWVFLAATFDYDQGTMALYKDGRPLTGFFTVSGDPWGVSGPPEPDLTSPTDPRGIKIGGSFPQNTAERNPCDCRMDSLMFLDRTVSAQEIWKQYRRMAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TT49</accession>
    <name>A0A1H5TT49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kynurenine formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65974">
        <property type="protein sequence ID" value="SEF65974"/>
        <property type="gene ID" value="SAMN04489712_101736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF65974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="28268" checksum="DCFEF4AE2850DB1F" modified="2017-01-18" version="1">MRLIDLSSPVDSSSYEPDPVTHEVLTPREGAVHMSSEMREHFGIEFDPAELPDAEFLSLDRIALTTHTGTHVDAPSHYGSRASYGDGVPKHIDQMPLEWFFNPGVVLDLTDAATGAVGADRVKEALDRVGYTPRPFDIVLLHTGAQRHAGTSRYFTDFAGLDGSAVHLLLDMGVRVIGTDAFSLDAPFGDIIARYRATGDRSVLWPAHFAGRDREYCQLERLANLESLPRPHGFRVACFPVKIAGGGAGWTRAVAVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TVU8</accession>
    <name>A0A1H5TVU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Act minimal PKS chain-length factor (CLF/KS beta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF66161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF66161">
        <property type="protein sequence ID" value="SEF66161"/>
        <property type="gene ID" value="SAMN04489712_101741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="4">
        <location>
            <begin position="252"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF66161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="420" mass="43585" checksum="FAE1F1723A7F104E" modified="2017-01-18" version="1">MTAATVVTGMGVLAPTGLGTTAHWSATLRGRSAIGPITRFDGTPYSSRLAAEINGFVAADHLPSRLLPQTDHMTRLALVAADWALQDAALVPAELPEYGAGVVTASSAGGFEFGHRELEKLWSKGPEHVSAYQSFAWFYAVNTGQISIRHGLRGPSGVLVTEQAGGLDAIAQARRHLRAGIPAMIGGGVDGSPCPWGWVAQQTSGRLSVARDPARAYLPFGEGAAGHVPGDGGALFVLERADTAAERGVRWYGEIAGYAATFDPPPGSGRPPTLRRAIERALDDAGAAPADIGVVFADAAGVPDLDRAEAEALRAVFGPYGVPVTAPKTMTGRLGAGGAALDLATALLALERGVIPPTVNVTRPVPAYEIDLVPRPRRVPLTAALVLARGHGGFNAAMVVRGGRGTRLPDNARRSETCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V5B7</accession>
    <name>A0A1H5V5B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82612">
        <property type="protein sequence ID" value="SEF82612"/>
        <property type="gene ID" value="SAMN04489712_102176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046086">
        <property type="entry name" value="DUF6104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19599">
        <property type="entry name" value="DUF6104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF82612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="59" mass="7067" checksum="921DE325F857FB90" modified="2017-01-18" version="1">MYFTDRGIEELAERRGAEEVSLHWVAERLREFVDLNPEFETPVERLATWLARLDDDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V6V5</accession>
    <name>A0A1H5V6V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83105">
        <property type="protein sequence ID" value="SEF83105"/>
        <property type="gene ID" value="SAMN04489712_102195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="34"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF83105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="386" mass="40348" checksum="4FD266A54F265F28" modified="2017-01-18" version="1">MRDPLARLREATERRDTAGLRRRLRPRSEDHDGLIDLASNDYLGLSRDPRLVEGAVRAVREWGTGSTGSRLVTGTTRLHRELDQRLAAFTGTPAGLVFSSGFLANLGAVTALSGPGALVVSDQVNHASIVDACRLSRSRVVIAPHRDVAAVQRALADRDEERALVVTDAVFSVDGDLAPLRELHQVARRHGALLVIDEAHALGVVGPHGRGAAHEAGLAAEPDVVLTLTLSKSLASQGGAVLGAPEVIETLVDTGRSFIFDTGLAPAAVGAALAALDVLAAEPELPARARDRAQRIRLLAEGLGFETTGPQGPAAAVVPVVLGDPHAAVRAAEICAEHGARVGCFRPPSVPPGRACLRLTARASLTEAELTVLEGALQKVRAETGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VC70</accession>
    <name>A0A1H5VC70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84830">
        <property type="protein sequence ID" value="SEF84830"/>
        <property type="gene ID" value="SAMN04489712_102257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF84830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="94" mass="9829" checksum="D9E386033D89067C" modified="2017-01-18" version="1">MEREPAALAMRIGVVAAQAALASFARNLDLDEVAEGGVDFRGAIGPAEWPVFSLVVDTLAAADPADDRPLDERRVDALNDLARICLAAKQAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VI39</accession>
    <name>A0A1H5VI39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86904">
        <property type="protein sequence ID" value="SEF86904"/>
        <property type="gene ID" value="SAMN04489712_102331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF86904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="189" mass="19292" checksum="B092C2214D43F025" modified="2017-01-18" version="1">MTGGLALLERAVNYTLGSLLAVTPQAMSRPTPCRDWDLRALLAHMNDSLLALYEAADLGRVDLEAPADPGGDPVAALRASACRLLGAWTGTAGGGSVAVADLPLAAEVVTAAGALEIAVHGWDVARACGLDRPIPDALAEELLPLSALLVTEVDRPARFAAPVPASPSAAPGDRLVARLGRTPGPIAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VUW5</accession>
    <name>A0A1H5VUW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90337">
        <property type="protein sequence ID" value="SEF90337"/>
        <property type="gene ID" value="SAMN04489712_102445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2017" evidence="1">
        <location>
            <begin position="8"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF90337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="178" mass="20162" checksum="EBA490BF711EED1A" modified="2017-01-18" version="1">MSEVKRVRRGIRLRLDPEEAALVRMMAEQLLALLGEPDEPDRSADPLAAALGISEHAEKPDDPVLARLFPDAYAEDAGAAREFRRYTEMGLRDGKREAAGIVLATVRSGEDVMLDKEQAQAWLRALNDVRLALGTRLDITEEWYEEVAELDRDDPRFAMYAAYDWLTMLQEQLVQALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W425</accession>
    <name>A0A1H5W425_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF94133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF94133">
        <property type="protein sequence ID" value="SEF94133"/>
        <property type="gene ID" value="SAMN04489712_102578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF94133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="79" mass="8742" checksum="1AE5405740EA10F6" modified="2017-01-18" version="1">MKTETREFLSDYTRTQVEQGRAEGKVEGIAEAILRLLAKRGIEVSAEVRDTVSGCTDMDQLDAWLLAAAKVDRAEDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W8D4</accession>
    <name>A0A1H5W8D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BadF/BadG/BcrA/BcrD ATPase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95516">
        <property type="protein sequence ID" value="SEF95516"/>
        <property type="gene ID" value="SAMN04489712_102622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="2">
        <location>
            <begin position="2"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF95516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="392" mass="38380" checksum="54C4E7F9596FD365" modified="2017-01-18" version="1">MIGVDAGGTRTRVAVLTLGGALAGSGTGPGANPNSGGDTAGALTTALGAALGDLDRSLVLNGVFGIAGAGSAGRPAALAAARRAWHAVGLHGSPAVVTDIAVAFAAGTGAPEGIVVFSGTGAGAAVINDGKIVQRADGYGWLVGDQGSAVWLGREAVLATLAALDGRGEPTLLAESVPRALLGPAAVDSLADGSARAPTAPVAEGPAGGRAMRARTPPERAFALASATAGASGALMPRGSDGPARPAAVDDEPPPDGRAPTTTLDRPDRMPPADPALAQAIIKEVYGRPPAALGRLGPVVCAAATAGDPVAQHITEEAAQWLLRDVDAVRPALTDPCSPVVMAGSVLGDGPVADAVRAGLRERFPVEPQQAGDGAVGAAGMALRRLGLRPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WDM1</accession>
    <name>A0A1H5WDM1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FO synthase</fullName>
            <ecNumber evidence="9">2.5.1.147</ecNumber>
            <ecNumber evidence="8">4.3.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SAMN04489712_102674</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the radical SAM superfamily. CofH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the radical SAM superfamily. CofG family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="9"/>
    <dbReference type="EC" id="4.3.1.32" evidence="8"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97356">
        <property type="protein sequence ID" value="SEF97356"/>
        <property type="gene ID" value="SAMN04489712_102674"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00293">
        <property type="entry name" value="((2_3_4_5-tetrahydroxypentyl)a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="77"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="530"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SEF97356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="873" mass="96341" checksum="76DA18BEDC179EDB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WEP0</accession>
    <name>A0A1H5WEP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell envelope-related function transcriptional attenuator common domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97828">
        <property type="protein sequence ID" value="SEF97828"/>
        <property type="gene ID" value="SAMN04489712_102691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="101"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="359"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF97828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="470" mass="50650" checksum="4252D0567AD58E6D" modified="2017-01-18" version="1">MNSNPMYMEYVDDADPAPERRRGWRVLGWVAIGLSVTLVSSSLGVYGYYRKLNGNIARENINYGPRPEKLNDALNILVLGSDTRTGANAKYGKSMKNDPPRSDTMILLHLSPGGEQAIGISFPRDLMVPIPSCRSREGGTVPASSLAMINESFTRGGAACTVKTIEHLTNIKIDHFLQVDFVGFKSITSAVGGVEVCLPKDVNDPQARLRLSKGRHTIEGETALAYVRVRKGLGNGSDTDRIKRQQQFLASLANKAMSAGVLSNPVKLNALLSASTKSLTTDEELNIGAMTKIARGMQGLTAGKLRFVTVPWGAYAPDPNRVALRQPDADRFFSAIRSDTGIAEERPAAGSSSKISPRQVRVRVYNASGIDGQARRVADQLEEQGYQVAGVGNLSSRRNTRVLYGPGAEHQAQALAEVVSGADRPAARANGSPGIVDLVVGPDWTALKPRKTGIPRQQDEVRATDDVCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X9E1</accession>
    <name>A0A1H5X9E1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_103151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG08359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG08359">
        <property type="protein sequence ID" value="SEG08359"/>
        <property type="gene ID" value="SAMN04489712_103151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="6"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG08359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="26165" checksum="CB27874CBEF7DE14" modified="2017-01-18" version="1">MSASTAVLKAELRLFSREPFSLFWIVAFPAVLLTILGLIPSFREPDPGLGGSRVIDLYVPVNVLLAMIMAGIQALPPVLSGYRERGILRRMSTTPVRPAALLTAQIVLHFAAALFSSLLVIAIGRLAFDVALPGHLPGYLLALLLGALGALALGAAVTAVTPTVKATTVVGSIVFFPMMFFAGVWVPVQAMPEVLRGIVEYSPFGAASQALHQAAEGGWPDWTHLGVTAAWAAVLIAAAVRWFRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XI97</accession>
    <name>A0A1H5XI97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11185">
        <property type="protein sequence ID" value="SEG11185"/>
        <property type="gene ID" value="SAMN04489712_103257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="35"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="478"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG11185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="569" mass="62741" checksum="1A76552790165265" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XIB5</accession>
    <name>A0A1H5XIB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11491">
        <property type="protein sequence ID" value="SEG11491"/>
        <property type="gene ID" value="SAMN04489712_103269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289485" evidence="2">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG11491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="10042" checksum="3C74A4F3BC915D10" modified="2017-01-18" version="1">MRSAGPWPRYRRLLGLSMVAAAAGGLAVAALGGTGAAAVTVGAGLAGTVVPFAVAIVLVLHDIREQQRRIIDQLETQTRILHRAARLAGELTDDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XVE1</accession>
    <name>A0A1H5XVE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15749">
        <property type="protein sequence ID" value="SEG15749"/>
        <property type="gene ID" value="SAMN04489712_103429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="41"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG15749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="28706" checksum="97FB5A29B366D099" modified="2017-01-18" version="1">MCGIPRRPADPEEIVVIAGRPRDLPLGGACLWALPLDASIAARARQLVGDVLGALAFPREQLDNGRLAVSELATNAFQHARPPAPLRPFGQVAPAELWMWARTYPRRELVVTVFDACRDRVPVARAGGGLDEYGRGLGMVAELCASWGTGPSRSLLQTRPIPGKTVWFTLPLPDPWPGAARLASPSRTAESLHAMLARRGVHGVITRHAKGVSLVSAPCGINVTMEPAAMRYMGTEGTYVRRPLTDLNDLAEHIVRRNETPTIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XWG4</accession>
    <name>A0A1H5XWG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG15875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG15875">
        <property type="protein sequence ID" value="SEG15875"/>
        <property type="gene ID" value="SAMN04489712_103434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG15875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="19347" checksum="3B36BA254BBF4DB9" modified="2017-01-18" version="1">MFEEESVKPEPVGAQERLALLDRLLTLPFREDEPLDDDHSAGPDHHLYALLASQDFWEDRSEEVVEAAQEEIDAAHRALAEAMTARWGKPETVDLWPYLERALDETAPVPEPIGTLCGLSGEMQVWRRPETGRWVALAVGQADPEFPIELLAAVGEIPALDAAMSAVRAADEGIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YYB1</accession>
    <name>A0A1H5YYB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28425">
        <property type="protein sequence ID" value="SEG28425"/>
        <property type="gene ID" value="SAMN04489712_104222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG28425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="20453" checksum="B30B854C6430ACD8" modified="2017-01-18" version="1">MTGSAADRYAQLFVEVTIRRARTADVPVIRRYIDTYAGNGRTLRKSTVTLYEDVQEFWVADDAELGVVGCGALHVMWEDLAEVRSVAVDGRCGGRGIGHRIVSRLLETARELGVRRVFCLTFEVEFFARHGFRPILGTPVSPEVYEELLRSYDEGVAEFLDLDRVKPNTLGNTRMLLRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZET7</accession>
    <name>A0A1H5ZET7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SAMN04489712_104507</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34600">
        <property type="protein sequence ID" value="SEG34600"/>
        <property type="gene ID" value="SAMN04489712_104507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="171"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="296"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SEG34600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="398" mass="45007" checksum="0992E64F0D3D25DA" modified="2017-01-18" version="1">MPTAVKRAFKYRFYPTPEQAAELARTFGCVRKVYNMALAARTQAWALRRQRITYNQTSAMLTTWKKTEELAYLNEVSSVPLQQALRHLQAAFTNFFAKRAKYPRFKSRKKSRDSAEYTTSAFRYRDGQLTLAKMAEPLHIVWSRPLPVGAKPSTVTVSRDSAGRWFVSLLVEDPTVRPLPASGNAVGIDAGLDHLLTLSTGEKITNPRHERADRERLARAQRNLARKAKGEGANRAKARRVVARIHARITDRRRDHLHKITTRLVRENQTLVIEDLHVRNMIKNGTLARAISDAAWSQFRSMLEYKAAWYGRDVIAVDRWFPSSKLCSECGARQEKMPLNVRTWTCTCATTHDRDVNAAKNILAAGLAVSACGAGVRPQRRPPGGQSAMKQEALRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZF27</accession>
    <name>A0A1H5ZF27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ORF">SAMN04489712_104520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34871">
        <property type="protein sequence ID" value="SEG34871"/>
        <property type="gene ID" value="SAMN04489712_104520"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG34871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="295" mass="30629" checksum="06540FD073F26BEF" modified="2017-01-18" version="1">MAIWLTDNSKVIVQGMTGSEGSKHTARMLRAGTNVVGGVNARKAGQSVDFDGRSLPVFGTVAEAMAETGADVSVVFVPPKFTKDAVVEAIDAAIGLCVVITEGIPVHDTAYFWSYASSKGNVTRIIGPNCPGIASPGKSNAGIIPADITTPGRIGLVSKSGTLTYQMMYELRDIGFSTCVGIGGDPVIGTTHIDALQAFQEDPETDAIVMIGEIGGDAEERAAAYIEQHVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAEAKKEALEKVGVRVGKTPSETARLMREIMKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZGK0</accession>
    <name>A0A1H5ZGK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34757">
        <property type="protein sequence ID" value="SEG34757"/>
        <property type="gene ID" value="SAMN04489712_104514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG34757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="211" mass="20354" checksum="2E1CC12D622D561D" modified="2017-01-18" version="1">MNASDFAAWIRRAAELVTADAERLTALDAAIGDGDHGLNLARGFGAAVTALDGLPAGTTPGKVLIGAGRAIVSKTGGASGPLYGTALRRAGKTLGDAAEPDAAALGTALRAALDGVRELGGAGEGDKTMVDALAAAVTAYETAVDGGAGLPAAARAAATGAAEGAEATVPMVARKGRASYLGPRSAGHLDPGAASTVLLLRALADVTGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZHT9</accession>
    <name>A0A1H5ZHT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AIG2-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG35811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG35811">
        <property type="protein sequence ID" value="SEG35811"/>
        <property type="gene ID" value="SAMN04489712_104562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG35811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="153" mass="16815" checksum="723245E0E9AD7650" modified="2017-01-18" version="1">MALYAAYASNMDPEQMARRAPHSPLRGTGWLQGWRLTFGGQDVGWDGALATVVEDPDEHVFVVLYDVPAWDEQELDAWEGAALGVYRKIRVRVQTLDGDVLCWMYVLDDYEGGLPSARYLGILADAAEAAGAPDDYVKGLRTRPCKSLGEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZXZ2</accession>
    <name>A0A1H5ZXZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol uptake facilitator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41368">
        <property type="protein sequence ID" value="SEG41368"/>
        <property type="gene ID" value="SAMN04489712_10576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG41368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="276" mass="28953" checksum="BFF255FE5A5D2494" modified="2017-01-18" version="1">MAEQRTPVPGTVGEMAAEFAGTMILILFGVGVVAQVVAGGLGDHDSIAWAWGLGVTLGVYVSARVSGAHLNPAVTFTLAVFRDFPWRKVLPYTLAQTAGAFVAALIVRWNYAEVLAKVDPDHTLKTQGVFSTLPGNGTLPVHTMGALRDQIIGTAILLFLILALTDPRNSGPAANLGPVVIGLVVVAIGFAWGTDAGYAINPARDFGPRLASFLTGYQGAWRDQYGELYFWVPIVGPLVGGVLGAGLYKGLVGRFLPTGDGTPPVDVPSRSHYEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A043</accession>
    <name>A0A1H6A043_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG41604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG41604">
        <property type="protein sequence ID" value="SEG41604"/>
        <property type="gene ID" value="SAMN04489712_10588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG41604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="190" mass="21071" checksum="66E30901C695FDFE" modified="2017-01-18" version="1">MARRRQLLGAAQEVFVAQGYHAAAMDEIAERAGVSKPVLYQHFPGKLELYLALLDEHAEALVKIVREALESTTDNKRRVQASMQAFYDFVAGDGEAYRLVFESDLRNVAPVRARVERANHQCAEMIARVIAEDTQAPSDEAFLLGMGLVGMAEVSARYWLSQHRSIPKDTAEKLIARLAWRGISGFPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2W4</accession>
    <name>A0A1H6A2W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42307">
        <property type="protein sequence ID" value="SEG42307"/>
        <property type="gene ID" value="SAMN04489712_105130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG42307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="210" mass="22785" checksum="5244357ECCFDC059" modified="2017-01-18" version="1">MRIPLVNPGLDLTSMAEPTLTSSTPGERPLRADARRNRERVLAAARAAFAQEGEEVQMEAIAKRAGVGVGTVYRHFPTKRALLDTLRRQWLADGAAHATLALSHVEPAKALTVFVRRAADLLARDRGIREAFERLDRGSGETVWSPEFEGYRTGVARLLDRAHEAGVLREEIDLSRFLALLSGVGAAVGNGLDPRLAADVLLQGIRPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A3I9</accession>
    <name>A0A1H6A3I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42635">
        <property type="protein sequence ID" value="SEG42635"/>
        <property type="gene ID" value="SAMN04489712_105150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG42635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="31159" checksum="35DCA6E3F0384527" modified="2017-01-18" version="1">MTYTEIEYEVQDRVATVTLNRPDRMNAYTFTMRNEMLDVFDRIDADDEVRAVVVTGAGRAFCAGADLEGGGDTFNKDKRQDMFGGDDLLEDGTPRDGGGTVALRIARCLKPVIAAFNGAAVGVGVTMTLPMDVRLASDKAGFGFVFARRGIVSEAASSWFLPRLVGISQAMEWAATGRVFDAREALAGRLVSRVYAPDELLPAAYELAREIADNTSGVSVAAIRRLMWSGLSSSTPWDAHVADSRLMAALGAAPDAAEGVTSFLEKRPAVFPMRVSTDLPAEVPDWPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AE74</accession>
    <name>A0A1H6AE74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46791">
        <property type="protein sequence ID" value="SEG46791"/>
        <property type="gene ID" value="SAMN04489712_105383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG46791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="482" mass="52305" checksum="3B64F8F120B25420" modified="2017-01-18" version="1">MPGAVPHFGRTGRRPGPIGALRARLGPGWPLTVIFIGFPVWWLLGLGAIIFLLMTVPMALHLWRHRDRVVVPRGFGWWLFFLAWVMLGVGTLWADAPGAVLGGGAGRLFVFLWRMSWYLAATVVLLFIGNLSERDLPTRRVADLLALMFIFTTAGGLVGSFLPNLELTSPMELVLPNALAKNAFVYDWIHPKVASIETILGFEQARPQAPFGYANVWGSAYAFFLPFFIITWLIQGGRWRRVTGTLILAISLWPVVYSLNRGLWLSLGLMSAFVIGKILMSGNVRAVRRTLAALTVGALLFAASPLPGLIQARLDNPHSNNRRGLLAEQTVRSALTGSPIVGFGSTRDVQGNFASVAGGDRPGCRACGVPPMGTQGHIWLLVFATGVGGTVSFIAFFVVRFARHWRERSHYGIAGCAILLCFGQFLFTYDLVEIPLFTVMVSTALTWRARRTADAAPGGRPGSDAEATAAIALGPAAAEPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AFP8</accession>
    <name>A0A1H6AFP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_105429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47589">
        <property type="protein sequence ID" value="SEG47589"/>
        <property type="gene ID" value="SAMN04489712_105429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG47589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="364" mass="37177" checksum="FE973A102EA43FE3" modified="2017-01-18" version="1">MPGSGRQTSRPAAGPGGRSDGRSDGVDGAATGPSGRPATRPTSRDVAQLAGVSQSTVSLVLAGKWTGRVSPGTAEAVHEAAARLGYRPNQAARSLRLGRTRTVLLVLPTLSSPFFGALYTGAARVAAGHGFRIVVYPWPDGAGPADNPFAAPHEAIDGILASSMAVEALSEFRGTPVVMLDSDPAGAAPTVDFDVADGMRRVAGHVLGLGHRHVGHVAADVDEWTFRSRGRALAAAVEATPGGRLSRVTAAIDVAAARRAAGGLLRRPDRPTVLVCDDDQLAAGAYKAARELGLDVPAGLSITGFDDVLLATALEPELTTVRLPAEELGAAGMATLLEMLEGGAPRSRSLPGELVVRGSTAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AH48</accession>
    <name>A0A1H6AH48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_105428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG47570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG47570">
        <property type="protein sequence ID" value="SEG47570"/>
        <property type="gene ID" value="SAMN04489712_105428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG47570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="409" mass="41101" checksum="CA045CFFCE3915D8" modified="2017-01-18" version="1">MRAYVAFLRLPYAGRLLGGTLLGRLPNGMGALAIVLHVRDQGGGYPLAGALAAVYGLATAAGQPVLGRVMDRLGQPRVLTASAWAAAAGFVLLAVLGTDPLPLTVAAVVLAGFATPPLEAGLRALWPVVLPGPAHVRAAYALDAASQEILFTVGPLVVVAAATLSTETALWLTGALGIAGTVVVTSSRPSREWRGEPRAADWAGPLRSPGMRTLVAALACAGIALGVYSVAVVAYAERLGSEAASGLLLAVMSGGALTGGLVYGARPWPGEDHRRLPYLLGGLALGYLPLALAPALPIMLVLAFLSGVFLAPVLACSFTLVDRLAPRGTVTEAFAWIVAAIGAGAALGSAVAGLGQDLAGVPGAFAGAGAGGILALAVCLLARHTIRPTKADVTILPMPGPQVGADETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AJP2</accession>
    <name>A0A1H6AJP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48983">
        <property type="protein sequence ID" value="SEG48983"/>
        <property type="gene ID" value="SAMN04489712_105508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG48983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="18671" checksum="94E38C09CC414378" modified="2017-01-18" version="1">MLGDRWGVTDREILRAYPCDDFVVSPTLRAWRGVGVNAPATVVWPWVAQVRLAPYSYDWIDNLGRRSPRQLVGLPEPRVGEAFTTAGGRKRGRILSVEPGKQLTGRIMNAVMSYVLVPEEHNTTRLLLKVVMRTNRVVALGLSVGDLVMARRQLLTFKQLAERCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AL25</accession>
    <name>A0A1H6AL25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG49241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG49241">
        <property type="protein sequence ID" value="SEG49241"/>
        <property type="gene ID" value="SAMN04489712_105522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG49241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="265" mass="29246" checksum="DA86C5FD738CAD5F" modified="2017-01-18" version="1">MSGDRRLRAAFDAAAALYQNARPDYPAELYGDLLAITGIAPPAHLLEVGCGPGKATLPLARRGFQITAIELGDALAAQARRHLAGFPDVSVITSSFEDWQPPAGVLFDLVYAATAWKWVDPQVKYAKAAALLPQGGHLAVWNAGHAFPAGFDPFFTEIQQVYDELGEGDGGPWPPPPPQERPDPTATEFETSGRFTVVGTRRYVWALRYTADEYLALLDTFSGHIAMAPAKRERLHREIRHRLATRPDRRLTRHWSAVLTIGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AXK1</accession>
    <name>A0A1H6AXK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52546">
        <property type="protein sequence ID" value="SEG52546"/>
        <property type="gene ID" value="SAMN04489712_10638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG52546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="524" mass="57697" checksum="0196B107EB997419" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AZX3</accession>
    <name>A0A1H6AZX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53615">
        <property type="protein sequence ID" value="SEG53615"/>
        <property type="gene ID" value="SAMN04489712_106104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="395" mass="40932" checksum="E5E1B880CD75923C" modified="2017-01-18" version="1">MAERKGGTVRDLRRDNRAVLLRALYFSGPRSRQELSAATGLSPASVSNVMRELLGEGVVAEVGSVDSDGGRPRVLLQVNPEYGYVVGVDVGETRVQVELFDLAMTERAKADFPLDPARHPADAVVSRILAGLDAVLADSGVPAEAIFGVGIGVPGVVQQRPEVVVDAQTFGWDRVPLERLLRAGTDLPLLIDNGANTMGQAELWFGSGRGTHNAVVGLIGSGVGAAIITHGTADRGSTASAGEWGHTPVVVGGRTCRCGNVGCLEAYVGAEAMLERYAEAGGTLAAADQESALAAMILEAGTPGTVGARIIDETVRYLGAAVGGLINLLNPERVILGGWAGLLLGETHLDAIREAARCHALKHPFATTSIELCTLGPDAVALGAATLPLELFLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B2L4</accession>
    <name>A0A1H6B2L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phenylacetaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54784">
        <property type="protein sequence ID" value="SEG54784"/>
        <property type="gene ID" value="SAMN04489712_106179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="11"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG54784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="483" mass="49629" checksum="EE2A65E74F2E0738" modified="2017-01-18" version="1">MTPRDLVAGEWADSSAELDLVLEDPATGEPLGPARATDGQRLERALAAAEAAADGWAARPAGERAELLEAVAAALEPAVDRIVALEAAATGVPIRQAAPLGMIVTGSFRLAAAGLREGGLEQAMTREDGRAVEVRRLPWGPALCLVPWNAPAPMAAHKVANALAAGCPALLKPSEFAPFGAQRFAEVVAQALAERGVPGGVFQLVHGDGATGARLTGDPRIRAVSFTGGAAGGRSVAAACAAGIKPVQLELGGNNPLVVMPDADPQRAARAAVDLLTTLNGQWCRALGRLIVPAGAQDALLEAIGERLAALRAGPPLEEDTDLGPLVHSRHRDLVAARRDALGGRLVSTTKVPDQGNYLAPALVVGVAPADATEEIFGPVATVHPYRTTEEAVALANGTSYGLEGYVVGADEDAALAVARRIRAGEVKVNGSSVMSLHLFAPRPAWGASGLGEEGTAETLRFFTNPRVVGVEGGFALHSRETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3I9</accession>
    <name>A0A1H6B3I9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WxL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG54696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG54696">
        <property type="protein sequence ID" value="SEG54696"/>
        <property type="gene ID" value="SAMN04489712_106173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027994">
        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
        <property type="entry name" value="WxL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293289" description="WxL domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="2">
        <location>
            <begin position="318"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG54696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="439" mass="42706" checksum="2C508BBB6CAFD756" modified="2017-01-18" version="1">MRRTRTALRGAAAALTAAGAVTVPLAAATPAHAGTGQVAYQCQIFGTKFDYNATVTVTAPASAKVGDEVTVEADFSDLPGVAPLPVNKWTTSGSLTVSGAQSGSVSIAVPERVGPIPAYGAVPIGKATGKLTLTTPGEVKLAPAALSILADAGAQATIACTPKSAPGPLAAIDVATGGPGVSVAPGTIHQGGAITLTGAGWEPGAVDVALCDSNGTECKAEDLTDVSASVGADGKLTGSATIAEEAAPGARTIVVTQGAVSKSVALTVTEKTPPPTGQCADKPVGQCGEQKINLTVNGGPLTMSQQPGEVDLTPITLNGTEQTATGDLRQVEVVDARGGSTGWSLTGTLTDFSSAAGTKISAGNLSWTPACTAGPGASAVTPGSAGPLDDTTAATLCSAPDGAGQIVGGTYTAGAALNLKVPPATGAGQYTAILTLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3N6</accession>
    <name>A0A1H6B3N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-aminobutyrate aminotransferase apoenzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55222">
        <property type="protein sequence ID" value="SEG55222"/>
        <property type="gene ID" value="SAMN04489712_106214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003867">
        <property type="term" value="F:4-aminobutyrate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009448">
        <property type="term" value="P:gamma-aminobutyric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004632">
        <property type="entry name" value="4NH2But_aminotransferase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00700">
        <property type="entry name" value="GABAtrnsam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG55222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="454" mass="48247" checksum="8D9D63F0792E06ED" modified="2017-01-18" version="1">MTSEYTAGVSELPQERRLVTEIPGPRSRELQQRRVGAVPPGVGSTLPVYVTDAGGGVLVDVDGNSLIDFGSGIAVTNVGNANPRVAGRVREQAGRFTHTCFMVTPYESYVAVCEALNRLTPGDHDKRSILVNSGAEAVENAVKIARYATGRPAVVVFDHGYHGRTLLTMTLTAKNMPYKHRFGPYAPEVYRMPLAYPYRWPTGPDNCGPEAAAQAIDQITKQIGADNVAAVVIEPIAGEGGFIEPAPGFLPALAEFCRANGILLVADEVQTGFARTGDLFACEHEGVVPDLVTTAKGIAGGLPLAAVTGRADIMDKVHPGGLGGTYGGNPLACEAALAVLAEIEEGKLVERARRIGEIMLPRLRDLAARHPQIGDVRGRGAMIAIELVRPGTKDPDPDLTARIVRHCHQSGLLVLTAGTYGNVLRFLPPLVIPEHLLNEGLDILTEALEATTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B3W8</accession>
    <name>A0A1H6B3W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55541">
        <property type="protein sequence ID" value="SEG55541"/>
        <property type="gene ID" value="SAMN04489712_106239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="560" mass="60907" checksum="D94246BCC07D058C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BDA6</accession>
    <name>A0A1H6BDA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG58821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG58821">
        <property type="protein sequence ID" value="SEG58821"/>
        <property type="gene ID" value="SAMN04489712_10724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG58821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="143" mass="15624" checksum="71188F1F3226D4F1" modified="2017-01-18" version="1">MLICHENLSEVVVEDIVVDMVVVDSERHTVVLLCGEIDCYTGPGLQTRLLDLAVTTGRPLILDMGGVSFCDGSALRMLSVTQRECATRGVALAVVGLRPFLANLFRALDMHERIPLCAALDEALWRLLPPADADIHRWLDTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BM20</accession>
    <name>A0A1H6BM20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7 8">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recA</name>
        <name evidence="13" type="ORF">SAMN04489712_107196</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61236">
        <property type="protein sequence ID" value="SEG61236"/>
        <property type="gene ID" value="SAMN04489712_107196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="11">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="12">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG61236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="367" mass="38739" checksum="936CFEA451E74D8A" modified="2017-01-18" version="1">MAANDRDKALETALAQIERQFGKGSVMRLGDEARVPIEVIPTGSISLDIALGIGGLPRGRVVEVYGPEGSGKTSIALHAVASVQKQGGIAAFVDAEHALDPEYAAKLGVDTDALLVSQPDTGEQALEIADMLVRSGAIDIIVIDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKMTGAINQTKTTAIFINQLREKIGVMFGSPETTTGGRALKFYASVRLDVRRIETLKDGTEAVGNRVRVKVVKNKVSPPFKVADFDLLYGQGISKEGGLIDLGVEHGFVRKAGAWYTYEGDQLGQGKENARNFLKNNPDIADEIEKKIKEKLGVGPRLDKEADAAPPAPAPAAPAAPTGRKAGAKAAKSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNC5</accession>
    <name>A0A1H6BNC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_107238</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61716">
        <property type="protein sequence ID" value="SEG61716"/>
        <property type="gene ID" value="SAMN04489712_107238"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="183"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG61716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="314" mass="34566" checksum="6823BC72E793F9C1" modified="2017-01-18" version="1">MVRRWHGLDEVPADWGRSVVTIGVFDGVHRGHQRIVGTAARLARERGLRSVVITFDPHPDEVVRPGTHPPLLSSTRRRAELLEELGTDVVILLPFTLELSRMSPDEFVQSVLVDRLHAAHVIVGEDFRFGHKAKGDVALLRELGDKYDFTAEGMPLVADGDTISSTYIRGRLAAGDVTAAATALGRPHRVEGVVVRGHQRGRALGFPTANLETMPHVAIPADGVYAGFLVCDSDRYPACRWPAAISIGTNPTFEGPGERTVEAYALDRDDLDLYGEHVAVDFTERIRDTLKFDSVEALVEEMHRDVARARELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNX1</accession>
    <name>A0A1H6BNX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62374">
        <property type="protein sequence ID" value="SEG62374"/>
        <property type="gene ID" value="SAMN04489712_107292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG62374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="163" mass="18215" checksum="16296A5935FA8F2E" modified="2017-01-18" version="1">MGNPPPTPPVPPPGYQYQYGHGPYDQWYGYGPPGVPADPQQGGPVTGDDTTWGLMCYLGTLIFGFLAPLVIYFARKNRSAFVRFHAAQALNYQITIFIQVMAPFLVAIPLAVVTNDPVWLVLVAPLAVFHMFAQWVFLILGTIRASQGRYHRFPVWTCFPMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPV0</accession>
    <name>A0A1H6BPV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62704">
        <property type="protein sequence ID" value="SEG62704"/>
        <property type="gene ID" value="SAMN04489712_107315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG62704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="248" mass="24796" checksum="12228250CDF3CB10" modified="2017-01-18" version="1">MDLGLTGRRAAVAAASGGLGLATARALAAEGVRVAICGRDRERVEQAAASLGADAVAIVADVGTPDGATGFVQRAQEALGGVDILVTNAGGPPPGTFESTGLDAYPAALDLNLMSVVAMCKAAVPPMRERGWGRVLAITSISVRQPISNLILSNTARAGATGFLKTLALEVAGDGVTVNSLQPGLHATDRLRTLHGGDLSAAAAGIPVGRVGDPDDFGAYAAFLCSEHARFVTGAAIPVDGGAYSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BVF5</accession>
    <name>A0A1H6BVF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64417">
        <property type="protein sequence ID" value="SEG64417"/>
        <property type="gene ID" value="SAMN04489712_10822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="18374" checksum="1D25F7FB78A8FC10" modified="2017-01-18" version="1">MSKLPQFPPNLPEVHVTGTSWRPRPMLLAVLAAFALAVTGCGGGGDGDKNGSAGAGQEGQGGQGGAYSSDGSPAPKEGAPLPKVQPVQVRPLVGRWVGAGPTKDYFVFRADGSGAWMARGRALWKGQVIPDGANKFRFSWEGRDPQQASYWGVTLESGGRKLVFGGTNQTYTKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C157</accession>
    <name>A0A1H6C157_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66704">
        <property type="protein sequence ID" value="SEG66704"/>
        <property type="gene ID" value="SAMN04489712_108216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG66704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="456" mass="49601" checksum="C7D75F3A9A59BC7D" modified="2017-01-18" version="1">MSGDGDPFTRAEHDTRATVAAPWWATAAPLQRQQALIARLVSLPDRSWWMYGAWARWYRWHPADGRWFPCSPPRGTMVRRSARPAQPGLSPPPIPAEILPAGPDFAYDHGPPLALAGRPVSGALLYRLRSVIQEAALAPPMDYPLGWSYFLHGTPSTIAATWSAMLWCASVPVFDPDLDSGGSPGLLGLWEPYLAQPFDDHGRLRWLVPPLLRTVIGLYAERMRAGRADAAGQIVRCMVMTAQALRDDPRFKVRASALLSIIEPLQANPALDHRSLPYGDEAMEREWTSRCPPALGTTLFADTAPGERFQMAVYDLAEALRPMCGDPESTAFTEPRYAAVALLAADMAGYRPDLAAPIGNWLDPELRGLLSDVIGQPGHGLRRLWPSRGRLPEDFRPADTDTALKALSAAAAVDFAWCRLAHGIPIPPDGFTVPDAFAAALDALAAKPATGEASEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C1F1</accession>
    <name>A0A1H6C1F1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3291 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_108222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66768">
        <property type="protein sequence ID" value="SEG66768"/>
        <property type="gene ID" value="SAMN04489712_108222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021708">
        <property type="entry name" value="DUF3291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11695">
        <property type="entry name" value="DUF3291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3291" evidence="1">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG66768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="19459" checksum="04EFC3E6DDD5A669" modified="2017-01-18" version="1">MLGGMSDFHLAQFNFARLRAPLDAPEMAGFLALRDPLNALAEGTPGYVWRPVSPVEGADEWPYGPDVLINYSVWESRETLWEYAYRSGHLEAMRRRREWFERAAEVYQVLWWIPAGHRPGPDECVERLELLRREGPGPRAFTFRTPYTAAEAARAEAEHATITQLDAARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C2Q1</accession>
    <name>A0A1H6C2Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66925">
        <property type="protein sequence ID" value="SEG66925"/>
        <property type="gene ID" value="SAMN04489712_108238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG66925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="412" mass="45264" checksum="0595997DD85EB030" modified="2017-01-18" version="1">MERQSRPLVLDPAGGDIHAEAAELRRRGAATQVELPGGVVAWAVTERDALRRLLADPRVSKDPYRHWPAWINGEIPQDWPLQLWVAVRNMFTAYGDEHRRLRSLVSKAFTVRSTAALRPQVEQITTGLLDRLAALPPDRRTDLREEFAYPLPIEVICRLFGIPEEARPELRTVVDGVFNTSATAEEAAANVQRLYAILTELVAAKRSAPGDDLASALIAARDEDGSRLEENEMVDTLILLISAGHETTVNLLDHAITALLTHPDQLALVRTGRASWDDVIDETLRWQPPVANLPLRYAVEDVEVGGVTIPKGEAILAGYAAVGRDPALHGADADRFDVRRPNKEHLSFGHGVHYCLGAPLARMEAEIALPALFDRFPDLALAVPPGELRPVASFISNGHRTLPVNLHKAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C372</accession>
    <name>A0A1H6C372_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Coenzyme PQQ synthesis protein B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pyrroloquinoline quinone biosynthesis protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pqqB</name>
        <name evidence="8" type="ORF">SAMN04489712_108284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in the transport of PQQ or its precursor to the periplasm.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PqqB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67401">
        <property type="protein sequence ID" value="SEG67401"/>
        <property type="gene ID" value="SAMN04489712_108284"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00653">
        <property type="entry name" value="PQQ_syn_PqqB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011842">
        <property type="entry name" value="PQQ_synth_PqqB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="49"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG67401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="304" mass="32345" checksum="735C3A0389DF73F7" modified="2017-01-18" version="1">MKIRVLGTAAGGGSPQWNCSCVQCARARRAGPPSWRTQDSLAVSGTGDTWYLVNASPDVRAQILLAPELTPRPGTRETPLRGVLLSSAELDHTIGLAVLREGAPLNVYAPPAVIGALSSAFPLRDVLAPYADHRWHAVEPGDPLRLDERLVVTAVSLGDKRPRYARGLPGRDWVVAYSIEDEVTGRRLVYAPNLASWPEEFDKAAAGADVLIADGTFWSDDELRRATRTPPRTAPTPPRATVMGHLPVAGPGGVGERLAALPGGRRLLTHLNNTNPLLDATSDQSLALASSSVEVAADGMVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C3W8</accession>
    <name>A0A1H6C3W8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="5">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ribA</name>
        <name evidence="7" type="ORF">SAMN04489712_108250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="5"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG67066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG67066">
        <property type="protein sequence ID" value="SEG67066"/>
        <property type="gene ID" value="SAMN04489712_108250"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="6">
        <location>
            <begin position="11"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="54"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG67066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="217" mass="23676" checksum="8F527B4AF7F84EB0" modified="2017-01-18" version="1">MHDLALTREDIAEADLVTRRGTFRTLAFRDPVDGHEHLALVLGEVGMREGVLVRVHSECVTGDIFAAMRCECGDQLDAALKAIVREGRGVLVYLRGHEGRGIGLVAKVRTHVLQDEEGLDTVDSATVLGFPVDRRDFGPAARVLRYLRVGSVRLMSNNNDKVHAMEAHGIAVASRVPLLIPANDHNIRYLTAKRDRLGHELPHLDASSRNGLGAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C934</accession>
    <name>A0A1H6C934_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HlyD family secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69403">
        <property type="protein sequence ID" value="SEG69403"/>
        <property type="gene ID" value="SAMN04489712_10980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="249"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG69403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="376" mass="36792" checksum="981C24F37174808E" modified="2017-01-18" version="1">MTRRPLIRRLPQAPVPARPALAVAIAVSVVIAVAVVVLWPGGGASAPAAASRGAADAEAVTTVTAAGTVRSADTRELAFGTSGTVTGLGVRVGDKVRAGQVLARLDDTEAREALEVAEAALNAAIEARDRPSGGGTQDQCVTTTMATTGSPLPTATRTVQPTPSPTRSTSPGGGGGDQPGGDGGDRSGGGGGGDQPGDGGGGRSGGGGRSGDDQSGGGCQAGGGGQAGGTGSSDRSAVQAEAQVTQAEARVRQARRALAGTRLTAPIDGTVLAVSGTTGTQVSGTGAGGFITLGDLTELQVEGMFSQSDLARLKIGQEAGITVTARPGEHFTGTVVHIDPAATVDGDLVRYGVKIAFDDSPQGLLEGMNAGVTITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CBE0</accession>
    <name>A0A1H6CBE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70244">
        <property type="protein sequence ID" value="SEG70244"/>
        <property type="gene ID" value="SAMN04489712_109153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="124" mass="13493" checksum="227CE045D1A1A2CB" modified="2017-01-18" version="1">MEFWHHGQVHLVPADRAHRPAIDQHRACEAIAAIGDRDRVAAWARRFDLLSEPGRLTLLLAIDSAGPISVTDLATAAGMSDTAVSQALRLLRTAGVVEPQRDGRVVRYRISDPGIRPLLKAATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEE8</accession>
    <name>A0A1H6CEE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_109261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71334">
        <property type="protein sequence ID" value="SEG71334"/>
        <property type="gene ID" value="SAMN04489712_109261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG71334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="155" mass="16856" checksum="0257DA5308B58D22" modified="2017-01-18" version="1">MPTLIVLRHAKAAEGLGLADIDRPLAGRGRRDAAATGDWLRENDLVPDLVLCSTALRTRETLEGLALPSPVEFEPGIYDNHVDVLLSLVQAVDDEVDRLLLIGHNPSVHGLVHELTNQAPREFPTCALAVIELSGGWYDTWSGTGTLALYRTPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLQ4</accession>
    <name>A0A1H6CLQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73376">
        <property type="protein sequence ID" value="SEG73376"/>
        <property type="gene ID" value="SAMN04489712_110103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295064" evidence="2">
        <location>
            <begin position="44"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG73376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="315" mass="34481" checksum="2081BAF6ECE878EC" modified="2017-01-18" version="1">METPDSTRGKRTARGGFRRATMALTTAAGAFLLASATAQPVAADPDNIKKVAELTKEIKSLEKEYGGNLEQLRDTRKEAKKALEKVELLRRDLIGARALVAQLAASQYMTNGIEPTVQIVASDDPGSVLSNASLARHLSQTHSAKVQQIASLVAQQDKARQEAEAKIKALEKDIAEIAKERDRVQLLLKKYKPESPMVGSGGMTPRMIKVRDEIEAEYGPFPVIGCTRPGDPLDHGSGRACDFMESTAGAMPSSARLAHGDAVSDYAIRNASRLGIKYIIWKQRIYDLRSPGWKMMSDRGSITQNHFDHVHISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CP40</accession>
    <name>A0A1H6CP40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74365">
        <property type="protein sequence ID" value="SEG74365"/>
        <property type="gene ID" value="SAMN04489712_110218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG74365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="63" mass="7053" checksum="F4F7EAD3816C68A1" modified="2017-01-18" version="1">MAIHWRKSSHSGSSNDEFCVELAELPAGVAIRDSKDPEGEWLTVRRTAFAELIRLIQDGALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CQM5</accession>
    <name>A0A1H6CQM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (Catechol pathway)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75309">
        <property type="protein sequence ID" value="SEG75309"/>
        <property type="gene ID" value="SAMN04489712_11115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG75309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="32304" checksum="25C5B20D6241C27B" modified="2017-01-18" version="1">MKLITFDEGRVGRLDGDDVIELDVPSTRAFFEREGRVGETGERLKLDQVRLRAPIRPRKFFHTAGNFADHHEELQAVNWSHPVHKGIVFFQNVDAIIGPDEPVVHPEHLTEELDYEIELAVIIGRPGKFFGPEQATEHIAGFTVFNDITARDIQRREMESGVFSFSKAIDTFCPIGPWIVTADEIEDMQDLALQLRVNGEVRQTGHTGQMRVSIPHLVAYHSPQVYSAGDIITTGTVSGVAAVQPNPFDFYLRPGDVIEAEIEGVGVLRNPVVSWQDAYGEPAPERVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2J0</accession>
    <name>A0A1H6D2J0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_112184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79218">
        <property type="protein sequence ID" value="SEG79218"/>
        <property type="gene ID" value="SAMN04489712_112184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="82"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG79218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="299" mass="32247" checksum="186766CA63EE1E6E" modified="2017-01-18" version="1">MSVKGAELELKSLPRVSARRRMADRTVQSLVYAAFVIAIIPLVSVLWMVVTRGMERLDLDFLTFSMNGLSSSDEGGGANHAIVGTLQQVGLTAVMAVPLGILTGVYLVEYGGNSRLARVITFFVDVMTGIPSIVAGLFILAFWLLALGFEYSGFAGALALAILMMPTVVRATEEMLKLVPNDLREASYALGVPRWRTICFVVLPTALTGIVTGVMLAVARVMGETAPLLLLVFITDAINSNPFEGPQGSLPTFIWYQAGDPNPQAIERAWAAALTLILIIMLLNLGARLLARLRKPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D4R0</accession>
    <name>A0A1H6D4R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80337">
        <property type="protein sequence ID" value="SEG80337"/>
        <property type="gene ID" value="SAMN04489712_11364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="92" mass="9186" checksum="CCC19614BBBC4E6B" modified="2017-01-18" version="1">MVTRQRAAIAESAQAAVSAAGRRTAAPATARPAPTRRSGEGGRQAGPSDGRPDGRKVQTSDGRGGNNGGGNNGGGDDSDRYAEGFERGGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D644</accession>
    <name>A0A1H6D644_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA processing exonuclease, beta-lactamase fold, Cft2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_113156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80810">
        <property type="protein sequence ID" value="SEG80810"/>
        <property type="gene ID" value="SAMN04489712_113156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="232"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="3">
        <location>
            <begin position="459"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG80810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="647" mass="69726" checksum="A41408BCB85FE72E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DAF0</accession>
    <name>A0A1H6DAF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, AcrR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82427">
        <property type="protein sequence ID" value="SEG82427"/>
        <property type="gene ID" value="SAMN04489712_11524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041673">
        <property type="entry name" value="TetR_C_23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17931">
        <property type="entry name" value="TetR_C_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="23518" checksum="5700ABBC01C8AC51" modified="2017-01-18" version="1">METALRLFRERGYEATTMRAIAKEAGVSVGNAYYYFGSKEELIQAYYDELQDDHMAACRAVLERERDFAPRLLGVLRARVDTMVPYHQFAGKFFKFAAEPNSPLNPFSAESGTARAAAIAIYREVVDGSTLRIDPDFRQELPELLWLYSMGIVLYWVHDSSPGCRKTYLLIERTVPLVNKMVSMSRMPGFKTVTRELVDVIRDVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DBR2</accession>
    <name>A0A1H6DBR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82771">
        <property type="protein sequence ID" value="SEG82771"/>
        <property type="gene ID" value="SAMN04489712_11582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG82771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="134" mass="14250" checksum="F845540FE5788A58" modified="2017-01-18" version="1">MAGVAVVDASAGVEVQYPSVQDDPLVEGGAEGPMQAVLKVELAPPVDDMGEEVTVERGVSGQQGLKIQFSFGRDQLVQPYLARRDLRPVPGPEPMLGVGTSVTDSLEDHPKSLRRGIKPEKAPGLAVHHFSNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCZ3</accession>
    <name>A0A1H6DCZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_115141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG83084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83084">
        <property type="protein sequence ID" value="SEG83084"/>
        <property type="gene ID" value="SAMN04489712_115141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG83084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="205" mass="22298" checksum="605D7350626C691B" modified="2017-01-18" version="1">MSRRLVNITLDNLDDLPRRCRGCVFWELDPVGGERAAEAGDPGLEKEAWISSTLLEWGSCGKIVYVDGVPAGFVLYAPPLYVPRSVAFPTSPVSADAVLLMTAHVLPEFSGGGLGRMLVQGVAKDLVRRGVKAIEAFGDLKGEEGGCMVPADYLLSVGFKTVRPHHRFPRLRLELKSALSWREDVEVALERLLGSMTPEGALRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DG95</accession>
    <name>A0A1H6DG95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylformamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83626">
        <property type="protein sequence ID" value="SEG83626"/>
        <property type="gene ID" value="SAMN04489712_11638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="74"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG83626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="293" mass="31313" checksum="9B2B52E547973806" modified="2017-01-18" version="1">MSVSPPDMAVREELDREYSPSLCARDAAATLARYAADSAEARRGLDCRPDIPYGPSPDERLHLFPPPRPDAPLLVFVHGGHWQESSKEDACFAAPAMVEAGAGYVALGYGLAPRRRLGEMVASVRRGLHWVREHAAEFGGCADAVHVAGSSAGAHLAAMAIAEVRVLADPRPPAEVAGAYLLSGVYDLEPIRRCYVNDALGLDDGAAADLSPVRWLPLRAGEVLVARGEAETRAYARQHALMVMALRAAGQRAADLVAPGRDHFELPLDLGVPGTPLGREVLRRMGLHGRRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DGI2</accession>
    <name>A0A1H6DGI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Butirosin biosynthesis protein H, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG84597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG84597">
        <property type="protein sequence ID" value="SEG84597"/>
        <property type="gene ID" value="SAMN04489712_11731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026935">
        <property type="entry name" value="BtrH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032369">
        <property type="entry name" value="DUF4872"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14399">
        <property type="entry name" value="BtrH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16169">
        <property type="entry name" value="DUF4872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BtrH_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4872" evidence="2">
        <location>
            <begin position="155"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG84597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="36488" checksum="C486F231020C6882" modified="2017-01-18" version="1">MTTVIDIDARGTQHCETTALGVLLRHQGLDLSEPMLFGLGSGLSFIYWDSKNMGFPFLGGRVKPFELTRNLAAGLGLELLVQETTSPRRAWENVTAAIDAGHPVGLQLDSYYLDYFTSKVHFGGHVVAMYGYDDHDAYLVDTDQQGGTVSTSLTSLAQARAARGPMTARHRSFTLTVPGNPPSPQGRIVPAITACADVFLNPPIANLGHRGIEKAGRLVRTWLQRTDDPQRDLPQAALLMEKAGTGGALFRNLYRDFLAECAQLLDSSHLRTGHGLYAEAATLWTETAALITKAGESGDAQCLVQAGAILCDLSRIEREAMQALIRLESEAPNALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DIH7</accession>
    <name>A0A1H6DIH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA reductase (LuxC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_117130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85070">
        <property type="protein sequence ID" value="SEG85070"/>
        <property type="gene ID" value="SAMN04489712_117130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07080">
        <property type="entry name" value="ALDH_Acyl-CoA-Red_LuxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008670">
        <property type="entry name" value="CoA_reduct_LuxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05893">
        <property type="entry name" value="LuxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="466" mass="51325" checksum="5EB277BB18374943" modified="2017-01-18" version="1">MSLTDTGTRIRVPHFVRGRLVWGEDTEYHSRDFGVPFVTPRLRLDELFEPRTVPGPAFDVPVSEIIDLLVETGRHLALDSNPYLQESLEMTARVSPLPRRVIENTYHRPGQFLTRRALEYRLERTFGGLDVLDGWVEHTDPDGNVSRVRAFPPRLVHMLAGNSPSGAMMSIADAALVKAVNVFKMPSADPFTTVAVLRTMADIAPDHPVLRSMSAVYWRGGDAQVEGVLYRSQYFDKLVAWGGGAAIESAAKYVAPGFQLISFDPKVSMAVIGREAFASEETLREVAELAATDATIYNQDACVAPRIIFVEGGIERADRFCALLCERLGMDRQFASAVGPKPPGDVREAVEGMRFLEPDYRIWGGYDGRGLVVRSPEPVDFHPTNKTVNVVPVDAMLDAAAHATVATQTVGVYPAHRKAELRDRLATAGVQRVVKLGSALKGSIGVPHDAMYPLHRMVHWVVDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKB4</accession>
    <name>A0A1H6DKB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_11830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85549">
        <property type="protein sequence ID" value="SEG85549"/>
        <property type="gene ID" value="SAMN04489712_11830"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="11">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEG85549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="18626" checksum="0FA47520B94080FE" modified="2017-01-18" version="1">MRDFLALAVQGVVAGVFALAVLGKLRGRDGFGRFATTVGRLTMRPGRPAVVIAAVVTAVEVVTTVLVAVPATARAGCWAASGLLVLFVAVVFRAVRGRVFAECGCFGGRGSVMSYPLLLRNLLLLALALTGAALAPADPPHPVPVHGAALVLGLAAAAVFLRSYDRLTAVVLTRLDPWAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKT1</accession>
    <name>A0A1H6DKT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4">3.7.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_11872</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85749">
        <property type="protein sequence ID" value="SEG85749"/>
        <property type="gene ID" value="SAMN04489712_11872"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="PTHR43069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="SSF63433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="FAA_hydrolase_N" evidence="9">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="117"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG85749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="416" mass="44746" checksum="D9EB05A0557B514F" modified="2017-01-18" version="1">MTDVSWAPVPEDSGFGIENLPYGVFTRPGELPRIGVAIGTAVLDLAGLAADGLLEDRRWFAAGSLNGFMAAGRPAWLASRARIIELLTIATYRERVEPHLIPLSQVELVRPVEVADFADFYSSIHHAANVGQIFRPDAIPLTPNWRRLPIAYHGRAGTVYVSGTPIFRPWGQRRDAHDSEPSYGPSQRLDLEAEVGYVVGVPSAPGWPLPTSAFRDHVFGFVLVNDWSARDIQFWESQPLGPFVGKSFATSVSPWVVPVAALEAARVPPPAQDPPVLPYLRCDEPWGLDLTLEIELNGHVIARPPFSSMYWTPPQQLAHATVGGAAVRTGDLFASGTVSGAGRPERGCLLELTWNGLEPLQLPDGTRRAYLQDGDTVTIRAFAPTATGARLAMGEVTGVIHPAPGSPAGTPTPGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKX7</accession>
    <name>A0A1H6DKX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_118122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85980">
        <property type="protein sequence ID" value="SEG85980"/>
        <property type="gene ID" value="SAMN04489712_118122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296013" evidence="2">
        <location>
            <begin position="33"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="4">
        <location>
            <begin position="42"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="162"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG85980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="492" mass="52600" checksum="E206AE0A632EFEB7" modified="2017-01-18" version="1">MICCRPSRRDIVRLSAILAGASLVPGLDPAQAYGSAVTASPVNLELVTLTETSAVFTWYTGEPGTDDGLGRMKPAPADGEIVYGTRPGRLNRRVAGERNTPYHYVEVTGLEPGRTYYYQARSRGRAASATFLAGGHAAGRPADRPRVFSFTTPQPPPGRFLFSVALCNDLHLGETVAGLVGQLPWIKGISQVPGHPPYPEIMTAALVADAGRRGAAYLLAAGDITSEAEPQDVGVARRLLDRFGTLGTDYFVARGNHDRGHEGAEYAGCGPGQWQGRDCFRDGFLDGTEPSYFARDLHGLRVVGLDTYDKPGDGGDAGGLSDEQLSWLRADLRAHRDQPTIVFGHHPLITPDAPQAITGGTSLQVRQAGAVLAEYSRAPGVFLHHAGHTHRNKRFALPGATGVLQQEVAAVKEYPGGFTLLRVHTGGYALNFYKTRAPLAREWSERSRQELAGLWPQLSLGSSVADRNTVVARDLSGVGRPVAGRASAARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLA8</accession>
    <name>A0A1H6DLA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_118115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85949">
        <property type="protein sequence ID" value="SEG85949"/>
        <property type="gene ID" value="SAMN04489712_118115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="15"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="4">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG85949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="35210" checksum="94CD5D6DCC77E5F2" modified="2017-01-18" version="1">MESPLLSLPGAVAADRPDQEVAAHYGEPAHEQRALESGTAFVDRSNRGVVRVSGPDRLSWLHSLLSQHLDRLEPHRPTQALLLSPNGHVEHHLHLVDDGEAVWAHVEPGTASALVEFLDRMRFMLRVEVADVTGEYAVVTGAVDVPGALELPDVAGPSRIIERSALPGLPEAARPAGLWAYEAFRIAAHRPRLGLDTDHRTIAHEAGWIGEAVHLDKGCYRGQETVARVHNLGRPPRRLVMLHLDGSADRLPAHGDPVELNGRTVGFTGSAARHHELGPIALAMVKRTVPVDATLLAGGVAAAQEVVVSPDTGANADIALRRRPAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DLG3</accession>
    <name>A0A1H6DLG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_118120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85971">
        <property type="protein sequence ID" value="SEG85971"/>
        <property type="gene ID" value="SAMN04489712_118120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG85971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="115" mass="11919" checksum="47A31AC2A0B8FBD7" modified="2017-01-18" version="1">MIKATSGTDGMERCNQAFTVAAAGVAAGSRVSLWLTGEAAWYALPGRAEEFELPHATPLQDLLEVVLAGGTVTVCTQCAARRDIGPDDVIPGVRIAGAPTFVEEISAEGAQALVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DN52</accession>
    <name>A0A1H6DN52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000019">
        <property type="protein sequence ID" value="SEG86183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86183">
        <property type="protein sequence ID" value="SEG86183"/>
        <property type="gene ID" value="SAMN04489712_11910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG86183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="294" mass="30227" checksum="37A545628DBC789A" modified="2017-01-18" version="1">MELHQLRAFLSVRDTGSATAAAARLGVRQSTVSAAIRALEQELAAQLFHRVGRGMSPTPAGHALVGPARRILRDCEQAAETLAAAGQGGRLELAALSTVVSGPFSSLVSAWLGAAPGRAIRVHDLDREDAVAEVLTGGTAEIVCTRLPVSPPVNDALTVLPIGSWGWRVAFPPQSGAVPEDAVTMRELSAVPTVLVAAGRNSALERATTRTPLSAAVVADQREARTALMLAGVGATIVGPRLAVDAAAAGAHVRPLDPPFTQSIGLVFDPVRLSPLAREFVAAAGEFDEGNAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DPT0</accession>
    <name>A0A1H6DPT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-2-oxovalerate aldolase</fullName>
            <shortName evidence="7">HOA</shortName>
            <ecNumber evidence="7">4.1.3.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-keto-pentanoic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-oxopentanoate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_120113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:36003"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17153"/>
            <dbReference type="ChEBI" id="CHEBI:73142"/>
            <dbReference type="EC" id="4.1.3.43"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36004"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22624"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:73143"/>
            <dbReference type="EC" id="4.1.3.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 4-hydroxy-2-oxovalerate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.39" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87332">
        <property type="protein sequence ID" value="SEG87332"/>
        <property type="gene ID" value="SAMN04489712_120113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008701">
        <property type="term" value="F:4-hydroxy-2-oxovalerate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07943">
        <property type="entry name" value="DRE_TIM_HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01656">
        <property type="entry name" value="HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017629">
        <property type="entry name" value="4OH_2_O-val_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012425">
        <property type="entry name" value="DmpG_comm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035685">
        <property type="entry name" value="DRE_TIM_HOA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07836">
        <property type="entry name" value="DmpG_comm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03217">
        <property type="entry name" value="4OH_2_O_val_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="17"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG87332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="344" mass="36408" checksum="E3666E9A7DE0FF8D" modified="2017-01-18" version="1">MPYSDTLDIRVTDSSLRDGSHAKRHQFTVDHVTSVVAALDEAGVPVIEVTHGDGLGGSSFTYGFSRTPEQELIKAAVKTATQAQIAFLMLPGVGVKDDIREAADNGARICRIATHCTEADVSVQHFGLARELGLETVGFLMMAHSQPPEVLARQGRIMADAGCQCVYVVDSAGALILEDTSDRVAALVAELGDDAQVGFHGHENLGLGVANSIAALRAGAKQIDGSVRRLGAGAGNTPVEAFVAVCDRLGIRTGIDVFKIVDAAEDVVRPVMDSECLLGRMEIMMGYAGVYSSFLKHAARHAERYGVSGAQILVRAGERKLIGGQEDQLIDIALELSKERAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQ92</accession>
    <name>A0A1H6DQ92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_120125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87401">
        <property type="protein sequence ID" value="SEG87401"/>
        <property type="gene ID" value="SAMN04489712_120125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG87401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="41988" checksum="809B684B20C8D84C" modified="2017-01-18" version="1">MDVRESAALGELRAELRAYFTGLLPEDERRRAGEQGVGGERFREVVKMLGADGWLGYGWPVEYGGQGRSVSEQYVLFDEVQRAGLPFPFVTVNTVGPTLMRHGTEEQKRRFLPGILSGDIVFAIGYTEPGAGTDLASLSTRAVRVGDEFVIDGAKVFTSGANTADYIWLACRTDPDAPRHRGISILIVPTDAEGFSWSPIRTVGGMSVTATYYSGVRVPATEVVGEVNGGWGLITTQLNHERIGLAALGGRMIRLWEDVLAWARDNGALELPWVRRDLARTHAKLEAMRLLNWRMTIAVERDELTGAEAGAAKAYGTETHIDVQRTLTGILGAAGRIRPESPGAVLAGQIEQLSRQGIVNTFGGGVNEVLRDMVATQGLGLPRSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQT6</accession>
    <name>A0A1H6DQT6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ORF">SAMN04489712_12058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87046">
        <property type="protein sequence ID" value="SEG87046"/>
        <property type="gene ID" value="SAMN04489712_12058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="8915" checksum="0C0C05A90DF4E18A" modified="2017-01-18" version="1">MLEEALEHLVRGIVEHPDDVQVRPRRIKGGRVLEVRVHPEDLGKVIGRSGRTAKALRTVIGGLSGGRYVRVDLLDVNEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DS64</accession>
    <name>A0A1H6DS64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_120133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87445">
        <property type="protein sequence ID" value="SEG87445"/>
        <property type="gene ID" value="SAMN04489712_120133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG87445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="86" mass="9355" checksum="A084F7278A41809A" modified="2017-01-18" version="1">MNIPVDPLSERERQAVILAHDVHDHLLCWLTRQGVIPGGLVVSPFVDASGQPSVLVRLSAPAARTLLRALTEPPPPAGPPRSRHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSE7</accession>
    <name>A0A1H6DSE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_120151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87535">
        <property type="protein sequence ID" value="SEG87535"/>
        <property type="gene ID" value="SAMN04489712_120151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="234"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG87535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="42336" checksum="1063F4114BC80A92" modified="2017-01-18" version="1">MSDEVLEAVRGLLPGIADRARSVDEKGRIPETTIRELTGAGVFRMLQPARYGGAEDDPVAFYRVVRDVAGACGSTGWVTAVLGVHAWHLALFPDAAQREVWDAGPDVLVASSYAPIGRLTPVEGGYELSGRWGFSSGCEFASWVLLGGLVVGAEGRPVDFMTVLVPAQDYEIHQVWDSMGLRGTASDDIVVDRAFVPEHRTMRNYDLAHLRAPGRKVNTGPLYRMPFGTVFTTTVAASVIGTVDGCYRSYVAAMRDRIRLSLGGGRFVEDQFAQVSVARAASEIDAAVLQTERNIREVYEHAVAGEPIPMELRLRARRDQVRGTERAIEAIDILFKTAGGNSLRRGHVIERAWRDAHAGSVHVANDPERALSMYGRGEFGLTVEDNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DSZ3</accession>
    <name>A0A1H6DSZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88487">
        <property type="protein sequence ID" value="SEG88487"/>
        <property type="gene ID" value="SAMN04489712_12212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG88487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="49" mass="5706" checksum="8A8E564D21F099C2" modified="2017-01-18" version="1">MHRSVRAHIEHALAHMKCWKILRDHHRKARSLHDTMAGIAYLHNLALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DTK4</accession>
    <name>A0A1H6DTK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_12257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88677">
        <property type="protein sequence ID" value="SEG88677"/>
        <property type="gene ID" value="SAMN04489712_12257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="208"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="359"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="459"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="565"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG88677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="716" mass="75434" checksum="62E69DFFDE9EB75F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU20</accession>
    <name>A0A1H6DU20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88750">
        <property type="protein sequence ID" value="SEG88750"/>
        <property type="gene ID" value="SAMN04489712_12272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="26113" checksum="B70A6EA68291CEED" modified="2017-01-18" version="1">MILTGAGAGIGRAVVARYVAEGARVVAVDIDEEGLASLADECGGAVVPLAVDVRSWEGNVAAVRTAVTEFGGLDVLVVNAGITDGARPLLDIDGPDLTGAFQELFAVNVLAGLLAVRAAADALIASRGAVIMTGSYASFHASGGGALYTASKHALLGVVRQLAYELAPDVRVNGIAPGIAPTRLRGIDALGQERSDSVLEGTAAVLPLQEVPSTESYGGLYTLLANATDSGHVTGTMISADSGLSIRGLARPGGRVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DVP2</accession>
    <name>A0A1H6DVP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89340">
        <property type="protein sequence ID" value="SEG89340"/>
        <property type="gene ID" value="SAMN04489712_12371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="136" mass="14221" checksum="67CACB99495B7211" modified="2017-01-18" version="1">MALFWAILVSFLAYALLRLARLLGEATKLVSELADQAAPLLDDMADTVRRANEQLGRTDVITKQVAGVTQNVSAVTTVMSTVFGGPVVKAAAFSYGVRKALGNNRDAERAETRAALPARRGSGGSGSSGGSGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWH8</accession>
    <name>A0A1H6DWH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89700">
        <property type="protein sequence ID" value="SEG89700"/>
        <property type="gene ID" value="SAMN04489712_12433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="52" mass="5828" checksum="077E9E0D38227381" modified="2017-01-18" version="1">MCGYARDCDAAVERLRSQGVRVLEEPADQPWGERMARVLDPDGNRLVILSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DWH9</accession>
    <name>A0A1H6DWH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator, heat shock protein HspR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89687">
        <property type="protein sequence ID" value="SEG89687"/>
        <property type="gene ID" value="SAMN04489712_12428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG89687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="148" mass="16552" checksum="0F2CBFD73E01B582" modified="2017-01-18" version="1">MDHFGDDTPVYVISVAAQLSGLHPQTLRTYDRLGLVCPGRTAGRGRRYSMRDIVMLREIQRLSQDEGINLAGIKHILELQRDNDRLRDELARLRAAVEELSNELESTRAVAARLAAQLRRGPAGPAGGDLVPIRRTSVVLWRDRNSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXZ1</accession>
    <name>A0A1H6DXZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000025">
        <property type="protein sequence ID" value="SEG90197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90197">
        <property type="protein sequence ID" value="SEG90197"/>
        <property type="gene ID" value="SAMN04489712_12566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="80" mass="8157" checksum="29A772C9E08D2C0E" modified="2017-01-18" version="1">MRKPAVLAPLLLGGMLTADCHSDGTAAGKPSAASALTAEPTAVPSAVPNGVERLTAQEILDRARETSLAVGSVRMRGEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYU3</accession>
    <name>A0A1H6DYU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90497">
        <property type="protein sequence ID" value="SEG90497"/>
        <property type="gene ID" value="SAMN04489712_12656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_C" evidence="1">
        <location>
            <begin position="246"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="388" mass="40532" checksum="D6B26FA5252EB033" modified="2017-01-18" version="1">MNDERRLRGGTAIVGVAESDLGEVGPDVTALDLMAQAAGRALDDAGLTIGEVDALFAHSAFFPMPTVVLAEHLGIRPRHSDSTATGGSSFVAHLRHAAAAIDAGLCEVALIAYGSTQRSASGGLISSGRSFLPSYETPFRPRLPVSAYALAAARHMHQFGTTREHLAEVAVAARRWARLNPAAFARDELSIDDVLGSRMVSSPLTVRDCCLVTDGGGAVVVTSAERARDLRRPPVYYLGAAEAHWHMNISQAPDLTLTAASQTGPRAFELAGLRPADVDVVQLYDAFTINVLLFLEDLGFCEKGAAGDFVAGGGIAPGGHLPVNTNGGGLSYCHPGMYGIFLLIEAARQLRGEAGDRQVADARVALVHGNGGMLSSQVTALLGDASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZY1</accession>
    <name>A0A1H6DZY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90847">
        <property type="protein sequence ID" value="SEG90847"/>
        <property type="gene ID" value="SAMN04489712_12756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="322" mass="34945" checksum="CB3EA87A59068743" modified="2017-01-18" version="1">MVMPVLNEERHLSDAVRAILGQDYPGELELVLAVGPSRDRTQEIAEKLATEDPRIIVVANPTGRTPQGLNIAIKASQYSIVVRVDGHSLLPADYVRAAVETMEETGADNVGGVMAAEGITPFEKAVARAMTSKIGVGAARFHTGGEAGEVETVYLGTFRRSALERVGGYDETFVRAQDWEMNHRIRQSGGLVWFTPRMRVTYRPRPDLRSLAKQYFHTGRWRRVVGREHQGTLNLRYLAPPLAVVAMAAGAVAGALGFWPGWLLPGGYVAVIMVGGSVATGRGLPLAAWLWLPLVYATMHISWGVGFLTSPPGLGQPSAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E055</accession>
    <name>A0A1H6E055_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90749">
        <property type="protein sequence ID" value="SEG90749"/>
        <property type="gene ID" value="SAMN04489712_12727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG90749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="137" mass="15305" checksum="0DBE245AF6484FED" modified="2017-01-18" version="1">MSEQGWRELTPETIPALLSVVECGDGCIRELTLRSTYGPDAAQSASVVIDVQHASEPGWVQLTIELRGLVHRKIVDIDTFSWVMLDQPQVVRDEAGLLHLDLDPTGEIRTPADMTQHSHVYLAARQLRWRLDPLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0U8</accession>
    <name>A0A1H6E0U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91192">
        <property type="protein sequence ID" value="SEG91192"/>
        <property type="gene ID" value="SAMN04489712_12858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG91192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="456" mass="48949" checksum="86B30B37AAEEE6B7" modified="2017-01-18" version="1">MRGASCGTVRIGPDGRRGRRGSGAGAASRSTPVSRHGRRPGHGLASRTGAATAVLLLGGLAAGCGPGDGGRPVIHLYNAPQRSIGALVERCNRLAHGRYRIVVGILPRDAAGRRAQIVRRLAAGDPGPDVIGMDVTWTAELAEAGWIRPWTGVHARRARQGTLARPLETATWRGRLYGAPYHTNVQLLWYRSDLIPRPPATWRGLIRESRRLAAAGKPHFGEVTGAPYEGIVVWFNSLVASAGGSVLTSAGDAVSLGEPGLRALRVMRDYDRSPAADPSLPSMRDDDARLAMEGGGVAYQVNWPFVYPSMAANRPHMLRHLRWAPYPGITGPGRAPLGGANFGISAHSRHPGQAFRAALCLRDAESQQIAAVRDGLPPTIRAVYDKPEMARAYPMRQEILRALDTAAPRPRTPSYQHVSTAISTVLSPPEAIDPPRTLARLRDLISKALEGRRAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E0Y4</accession>
    <name>A0A1H6E0Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative flippase GtrA (Transmembrane translocase of bactoprenol-linked glucose)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_12749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90823">
        <property type="protein sequence ID" value="SEG90823"/>
        <property type="gene ID" value="SAMN04489712_12749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG90823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="218" mass="23360" checksum="2BCE3E12089ADF23" modified="2017-01-18" version="1">MSLVANLYRRFEHLVRELAKFGSVGALAFVITIGVANALQFGLHLGPLKSNAAATVVATTFAYAANRYWTFRHRDRSGLGREYALFFALNGIGLVITNLVIGFTHYGLGQDGPLAYNAALIVGTGIATLFRFWSYKKWVFLPAEAPPVDPASGLPETPPAPRPDAVDDAVNGVTAPANVPANGVTGRGARHRAHNGVRVRDHDVPAEPAGRPAPARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E477</accession>
    <name>A0A1H6E477_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000032">
        <property type="protein sequence ID" value="SEG92069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92069">
        <property type="protein sequence ID" value="SEG92069"/>
        <property type="gene ID" value="SAMN04489712_13211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="431" mass="45697" checksum="AA9CBC5F7870C54A" modified="2017-01-18" version="1">MGQFLLSATLACLGAGLVVTALLLARQRNVTDRLRRRNAELADVLRLQEEELRHLAAVRLPQLRDRLEGRPVTVSGPLDERRIAATGLDKTMTAVMRLFTEAVESAKANAEQSAKGTLKAMMRTVQSLANEQQLAISDMQQRHDDPEVLAGLLRIDHMNAQLGRRAQATAVLFGSWPGQQRSAAPVVDVVRGATSRIRDYLRVQVSSEVSVAIVGRAVEPVVLAVAELLDNAARHSQPNTPVEVNFQLAHNGVAIMIDDAGVAMNSEEIQRASALLSGRDLGDIARLGDPPRIGFAAVGVLAARYGFTVSVDTRSPYGGVRAVVFVPNDLLTKVDDGQDAAPAAPAEPKTVPATRSAPGPLPRRRRMDAARDASADPAGPAAARPARPPKEVAAGLGAWQRGTRSGRAAAAGADPGNATEPASDIEGNERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E562</accession>
    <name>A0A1H6E562_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92830">
        <property type="protein sequence ID" value="SEG92830"/>
        <property type="gene ID" value="SAMN04489712_13543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="2">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="83" mass="9536" checksum="C18D5B8F234CE056" modified="2017-01-18" version="1" fragment="single">MIREIHAESRGSHGSPRVHAEPALGLGEQVNRKRVERLMRRAGLQGVYRRRGRRDLVNAATEEDLVQRHFDVAGPDRLWLTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E663</accession>
    <name>A0A1H6E663_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000038">
        <property type="protein sequence ID" value="SEG93278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93278">
        <property type="protein sequence ID" value="SEG93278"/>
        <property type="gene ID" value="SAMN04489712_1386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG93278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="234" mass="25220" checksum="02D42656BAAC0B7A" modified="2017-01-18" version="1">MTARAGKQADIDQVGTEVTSSANPPPWLDRFLTEAPRMTVPSYMRPPDGARPAAVLILFGEGPQGPDVLLTQRAATLSKHAGQPAFPGGRIDPTDDGPVAAALREAYEETGLEPSGCDVLTTLPELYLLRSNYRVTPVVAWWREPSEVSPGHPGEVAAVARVPLAELTDPDNRLSVRHPSGYAGPAFRVRGMLVWGFTAGLMTQILRLGGWERPWDPDRTEDLPPDVVALSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E6X5</accession>
    <name>A0A1H6E6X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000039">
        <property type="protein sequence ID" value="SEG93452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93452">
        <property type="protein sequence ID" value="SEG93452"/>
        <property type="gene ID" value="SAMN04489712_1392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="36" mass="3846" checksum="2524A6BD92EB7D57" modified="2017-01-18" version="1">MGKHDEKKDGDGKWDKPVPPPDPKNPPGGGRHEKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E8R9</accession>
    <name>A0A1H6E8R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_14321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000043">
        <property type="protein sequence ID" value="SEG94140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94140">
        <property type="protein sequence ID" value="SEG94140"/>
        <property type="gene ID" value="SAMN04489712_14321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG94140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="159" mass="16860" checksum="2893659A128E2819" modified="2017-01-18" version="1">MRSREQLLEVMDRVCADVRDKAVNAAEVPERLVVVAGGTGSVAHPEGVDVYEGGGVIAFVNDSGVPFVEQAEQLIAKAVTLKPEAVLLGGSALIGRPGGAYRRILAVQLFSELHGIRMARVADVDPSKGPIRSVAPWREAKAGPPMWAEEILTRAGHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9Z0</accession>
    <name>A0A1H6E9Z0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_14819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000048">
        <property type="protein sequence ID" value="SEG94547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94547">
        <property type="protein sequence ID" value="SEG94547"/>
        <property type="gene ID" value="SAMN04489712_14819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG94547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="176" mass="19800" checksum="DEDC78688101EF30" modified="2017-01-18" version="1">MSWEKEPLVPLRALANPLRIRIVSLLTGTAMSATEVAEELGLAHASASYHLRQLAAAGFLEQVDDDPAVKGRPGRGRSPKRYRYDPTSAERLDRSSGRRLLQEATFTDLRRRLDAMTRQRQSADAEVWLHTEDWERVCSLVGEAVRLLHENARPPRSEGTVHVSMTTILFEMPDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EA59</accession>
    <name>A0A1H6EA59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_14015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93695">
        <property type="protein sequence ID" value="SEG93695"/>
        <property type="gene ID" value="SAMN04489712_14015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG93695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="258" mass="27753" checksum="C00F769D1554183C" modified="2017-01-18" version="1">MTAPLSPEPVLRVRNLATGYGDLRVVWDVSLDVRPGELTVLLGRNGAGKTSTLRAVAGLNKASAGSVELAGADVTRTPAHRRVRQGLAYVQEGKRVFHRQTVEQNLVVGGYTRGMSRSALRAEAEGIYEIFPVLGDKRNVLAGDMSGGQQQMLAIGQALMAAPKVLLLDEPSGGLAPVIVGQVMEQVARLREHGIGVLLVEQALEASIRVADHIVVLDMGRVLVSVRKDDLDDIATLREAYFGRRAGHEPLRSSPDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S0G6</accession>
    <name>A0A1H5S0G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44102">
        <property type="protein sequence ID" value="SEF44102"/>
        <property type="gene ID" value="SAMN04489712_10130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF44102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="100" mass="10706" checksum="CCDA5284DEF20E27" modified="2017-01-18" version="1">MGDGRRSYDTGASGEAQGNIHTIISRLEALIGSRDADVATAMSDFEATGVSEEYRAKELKWHNAANETREIIQLVKATLEKNDEIAQTTLGKAGAAVQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SPV4</accession>
    <name>A0A1H5SPV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51871">
        <property type="protein sequence ID" value="SEF51871"/>
        <property type="gene ID" value="SAMN04489712_101282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="52"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF51871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="558" mass="60327" checksum="746CFBD8143CA4FC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SRW4</accession>
    <name>A0A1H5SRW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="7" type="ORF">SAMN04489712_101309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF52517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF52517">
        <property type="protein sequence ID" value="SEF52517"/>
        <property type="gene ID" value="SAMN04489712_101309"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF52517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="197" mass="21088" checksum="921E3E7E510472CB" modified="2017-01-18" version="1">MSRIGRVERGTKETTVAVEIDLDGTGQVDVATGVGFFDHMLAQLGKHGLFDLTVKTTGDLHIDSHHTIEDTAIALGQAFAQALGDKAGIRRFADASVPLDESLAQVTVDLAGRPYLVHTEPAGMAPMIGPDYDTTLTRHILESFVSNARIALHVHVPYGRNAHHIVEAQFKALARALRDAVALDPRVQGVPSTKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SSG5</accession>
    <name>A0A1H5SSG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF53370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF53370">
        <property type="protein sequence ID" value="SEF53370"/>
        <property type="gene ID" value="SAMN04489712_101340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF53370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="29192" checksum="4AAE76D8E94E7F46" modified="2017-01-18" version="1">MRGGPEPVRRDHDPAGPGEPRPRPGRRGFPPVVLFGAAAVIIVVLVAGIAVLTAGAGEEDTVRRAGGPQASVGRPADSGSSPSSYSSSPSTDAYAGIDQRGEDGSPLTEEEAFPSSARSLTVKEAGSRLKLVGKRLDGDCAHAVWGRAVGDELRRGGCLQAVRGMYADTGRGYALSVTIFNLASSADADRLVDALGRGRGGGFVRPLTGADDGVTVRPTASATAGASALEGFGQGFSMARGLAMGHYAVISWAQRLDGEGDETDEALLALLIEGGKAPAVLGRAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T4T8</accession>
    <name>A0A1H5T4T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450, family 142, subfamily A, polypeptide 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF57037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF57037">
        <property type="protein sequence ID" value="SEF57037"/>
        <property type="gene ID" value="SAMN04489712_101458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF57037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="402" mass="45278" checksum="7AF4CBECF60D2C33" modified="2017-01-18" version="1">MPDHSVNDAINLISGEFWGRNPHEELRWMREHAPVYRDELGGVWGISKHADLKLVSRTPEVFSNAHGIRADAMPMPMMIDMDDPAHKMRRKLVSAGFTPRRVAAQEDYLRRICDEIIDGVCERGECDFVADIAAPLPLIVIGDALGFAPEDRHLLLTWSDDMVRGLTGGDNPDLLVKAGEAFNGFTEYAGRAVAARRDHPRDDLLSILVHAEVDGDRLDHDSLVQESLLILIGGDETTRHVVSGGMYQLCVHPDQRRKLIEDPGRIPTAVEEMLRWVSPIKNMNRTATRDFELRGQQIKAGDKVLLLYPSANRDEEVFTDPFRFDVERTPNDHIAFGNGPHFCLGNSLARLELRVMFEQLLKRLPDIEPVEDEEPAHRPANFVSGYETFKVRFTPSPRLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TIM6</accession>
    <name>A0A1H5TIM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62732">
        <property type="protein sequence ID" value="SEF62732"/>
        <property type="gene ID" value="SAMN04489712_101637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021487">
        <property type="entry name" value="DUF3140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630">
        <property type="entry name" value="PTHR40630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11338">
        <property type="entry name" value="DUF3140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF62732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="114" mass="12841" checksum="2CEDE1E08D6030D5" modified="2017-01-18" version="1">MHERVSPEVETLWEEFHHAVNMSSQELRTWLLTEASGEVEFPADPDLNVPELGGRVLQVLSKRKVDLTGDDIETMRQVVGTVSRRLADPPRKGAGDDHWRHALMTLGHDPLKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TS57</accession>
    <name>A0A1H5TS57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase auxiliary protein/glycosyltransferase auxiliary protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65580">
        <property type="protein sequence ID" value="SEF65580"/>
        <property type="gene ID" value="SAMN04489712_101725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030958">
        <property type="entry name" value="P450-rel_GT_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04515">
        <property type="entry name" value="P450_rel_GT_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF65580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="451" mass="48249" checksum="8950DDB0B81ECBC0" modified="2017-01-18" version="1">MREGIEGGYSACSYVGRMVQTATDSKLGDNLLTLRGVQWILGTKDDPYALLLRAASDDPRELGRRIRERGPLSFSHAMAWVTASAEPGEAVLGDARLSPRHPDDRTETAEDADAGAEAMPWDIPVLRKVLPLRDAFVTLDRADYVRLARWAEPVIAGALARRREVIADRYRARVRDLPGEFDLMTGLARDVSAAVVADLLGLPAGRRERFAQLCAGTAGTLDATLCPPRLAAARDLLTSLAEMRKLLGEAVESARTSPGEGLAGELLRAAADDAETGPDDVLAVCVLLAVVGSDTAANLVCETVAALLDHPDQWKLVRADPGLAAAAVEETLRYAPPIRLHQRYAQEDLELAGQRIETGQEVVVVAEAANRDPAVHGDPDGFDIRRPRIRHLTFPEGSPVALAASLARAQAAAAVTAVATGLPDLRRADGVLRRLRSPATAAVLRLPVRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TX03</accession>
    <name>A0A1H5TX03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted kinase, aminoglycoside phosphotransferase (APT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67303">
        <property type="protein sequence ID" value="SEF67303"/>
        <property type="gene ID" value="SAMN04489712_101777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="36"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF67303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="36912" checksum="734375AD6ABDFACA" modified="2017-01-18" version="1">MSTETAPLDGLDLPALERFFAERVPGFGGRLTAELMQGGRSNLTYRLSDGCTTWVLRRPPLGGLTPSAHDMQREYRVVAALSDTDVPVARAVAFAEADVLGVPFAVVEYVDGTVIRTIEELHALPQEEITGCGHGLIDVLARLHAVDPAEVGLAGFGRPDGYLARQVRRWYDQWQRVRTRELGDIDRLHERLAATCPAESGACIVHGDYRIDNAILDPADPGTVRAVVDWEMATLGDPLADLGLHLVYADPAFAPVLAGTAASTSPRLPGIADLAQRYARSSGRDLGDLQFYLALGYFKIAIIAEGIHARFRQGMTRGTGFDTVGQAVAPLAAAGLRTLAQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TXC0</accession>
    <name>A0A1H5TXC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_101781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF67446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF67446">
        <property type="protein sequence ID" value="SEF67446"/>
        <property type="gene ID" value="SAMN04489712_101781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF67446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="6914" checksum="BB6FEB0DED46B7C7" modified="2017-01-18" version="1">MLAKLEIDIPMCQAHGRCYETAPDVLDADDNGVAVLKSDEPIDAERARAIAATCPEFAILVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UTY4</accession>
    <name>A0A1H5UTY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF78420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF78420">
        <property type="protein sequence ID" value="SEF78420"/>
        <property type="gene ID" value="SAMN04489712_10220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF78420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="455" mass="46413" checksum="5BF91E08C9A6CFAF" modified="2017-01-18" version="1">MPTPEPCSNPTDPGCVQQSPESEDTGGGSPFGVPGPEDIGAGALDGIADAMRAGLRWFLENTMTWWVKLDSPDLQQEPAVGQLQQFMLPITGAVAVLAMLAAAGKMALTHKANPLLNVGGGLALIAVTGAIGVALPNQLLKFGDAWSDWVIRSAAGEDFEKRMPTLLGLEGLPAALVIVFGLVAMVVAAIQAILMMFRHGALLILAGVLPLAAAGTLTGVTRPWFKKVTGWMLALIFYKPAAAAVYAAMFTLIGKGNDIRAVLMGFAMMLVSLVAFPVLLKFFTWTTGTLEAGSGGAFMGALIGGATAVGALRGPLSGSASDHASFLNQQLGPSGADTDSPEGARPQHGRSETTSADGHSATSAPGPGQGRPPGPGPGQSHPLDFQDTPSNTGQSTSGVDPDEPVGPVVWQTARNEERRGRDTLRWLNHPTGSGPSGAADSGPEGGDGGSGGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UX65</accession>
    <name>A0A1H5UX65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_10274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79675">
        <property type="protein sequence ID" value="SEF79675"/>
        <property type="gene ID" value="SAMN04489712_10274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF79675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="18974" checksum="6A4BB2FBCA65A0F7" modified="2017-01-18" version="1">MADRAEFGQYVAARSERLLRTAYLLCRDWATAEDLVQTVLTKAWLAWDRVGDDPDPYVYRILTNTHVSWWRRRWRGEVPTERLPEPSVPPGPLTSQVEDRDLLWDALGRLGRRERAAVVLRYFADLEHTAIAEILGCSPGTVRGHISRALAKLRADLAVAPVRERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5UY03</accession>
    <name>A0A1H5UY03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, GT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF79893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF79893">
        <property type="protein sequence ID" value="SEF79893"/>
        <property type="gene ID" value="SAMN04489712_10282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF79893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="339" mass="36646" checksum="3ED1C09464942894" modified="2017-01-18" version="1">MNISVVICAYTERRWDDVHAAVASVRAQRHRPYEIILVVDHNPDLLQRLAASLPEVTVVANAERRGLSGGKNTGVAVARGDVVAFLDDDAVAAPGWLAAFAKHYDDPAVAGVGGRTLALWPGSPSSAELRYGHRLLEGGEPAEAGRRPAWFPEEFDWTVGCTYRGMVPGPIRNLMGGNASFRREVFAVAGGFADGIGRSHHRRPLGCEETEFCIRLRQRSPRSELVYDEEAVIWHRVPAERARFAYFRERCYAEGLSKALVTRSVGTGDGLASERAHALRTLPRGVARGLRAAVRGDAAGLGRAAAITVGLAWTVWGYGVGSASGVRRSEEPAMVGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V191</accession>
    <name>A0A1H5V191_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine dioxygenase type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF80984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF80984">
        <property type="protein sequence ID" value="SEF80984"/>
        <property type="gene ID" value="SAMN04489712_102120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF80984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="165" mass="18572" checksum="DD79763858834605" modified="2017-01-18" version="1">MALDGLPERNLDRRELQKLVDGLAERPELWRDQVAYSSDRRHYASLHRDEYVDVWLLCWTPDNDTGWHDHDVSSGAVRVVSGALKECNPRIGGAHLETVVPEGSSFSFGPDHIHRLVGAADASVSIHAYSPPLWRLGQYSIDRNGVMRRVSVSYADELRPLDEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VLC5</accession>
    <name>A0A1H5VLC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-Dimethylarginine dimethylaminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF88079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF88079">
        <property type="protein sequence ID" value="SEF88079"/>
        <property type="gene ID" value="SAMN04489712_102366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF88079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="302" mass="32639" checksum="75BE036E986D5A00" modified="2017-01-18" version="1">MTVSPAMEPTTSTSPSSQTGSPAVATGPDATAARERVALPRRFLMCRPEHFAVTYAINPWMDPVAGADRDLALAQWEALRAAYLSLGHRVELIEPIEGLPDMVFAANGALVVGGRVYGARFHHPERRAEGPAYAEWFRRNGFTEILEPAHVNEGEGDFLTLEEVILAGTGFRTEIAAHQEAQEHLGRPVVTLRLVDPRFYHLDTALFPLGGHNVAYYPGAFSPGSRAVLERLFPDAVLADEADAAVLGLNAVCDGRHVVINAEAAGLIGALRRRGYEPVPVDLSELRKAGGGPKCCTLEIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W7D7</accession>
    <name>A0A1H5W7D7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murQ</name>
        <name evidence="5" type="ORF">SAMN04489712_102620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95449">
        <property type="protein sequence ID" value="SEF95449"/>
        <property type="gene ID" value="SAMN04489712_102620"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="55"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF95449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="298" mass="30813" checksum="DB3FABAC977268D5" modified="2017-01-18" version="1">MIDCDVPTEGRNPRTVDVDVLPTIEVLRLINAEDTTVPAVVAAVLPQIAELVDLAVESLRAGGRVHYFGAGTSGRLAVIDAAELPPTFGLWGRVVAHHAGGLGALSQAIEDVEDDADLGARDAADVHPGDIAIGIAASGRTPYVAGALRAAVRTGARTALISANPRAPLGEEVDVHIGLATGPEVITGSTRMKAGTATKLVLNAFSTTLMIRLGRTYSNLMVSVNALNDKLRARLVRILTEATGMDAGICETALSEAGGDTRVALVSLLGEVPAARATLALQESQGGVREALQRLRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WCD7</accession>
    <name>A0A1H5WCD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinicin-like metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF97132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF97132">
        <property type="protein sequence ID" value="SEF97132"/>
        <property type="gene ID" value="SAMN04489712_102666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF97132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="158" mass="17385" checksum="1CF3C6C7A762D157" modified="2017-01-18" version="1">MSEKAPGARIRRRDRHGRGVRGPLMPPEAPFALTRAERFDGLVRDEVNRLGRRWGRELAQVEFAVEDVPRIEPLAGVLDVGDPVPLSQTHPAANGRPPRIVVFRRPLEARAGLADTGGSGIDERELTRLVRDVLVEEVADLLGLSPESVDPSYDSPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WYD9</accession>
    <name>A0A1H5WYD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone DnaK (HSP70)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_10320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG04679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG04679">
        <property type="protein sequence ID" value="SEG04679"/>
        <property type="gene ID" value="SAMN04489712_10320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG04679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="527" mass="57190" checksum="4BBC431EF485FC75" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XFM3</accession>
    <name>A0A1H5XFM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_103233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG10551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG10551">
        <property type="protein sequence ID" value="SEG10551"/>
        <property type="gene ID" value="SAMN04489712_103233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009289378" evidence="2">
        <location>
            <begin position="27"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG10551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="432" mass="46002" checksum="3A47821DE46FB8D2" modified="2017-01-18" version="1">MRRTPLVSVLAGLALALTACGGDGDGDTTTAGSGGGELTGRGPITLVSGKDRSGNMQKMVDGWNAAHPNETVRIIELPDEPNDQRQQMIQNATTRSDAYTVLNLDVVWTAEFAANRWLAELPKNQLDTAKLLPATVTTGEYRGRLYAMPLTSDSGLLFYRTDLLKKAGVSEPPKTWAEMWDACDKVKKLPEGKGVDCYLTEVGKTEGLTVTAAEAINSTGGNIVDASGKPAVNTPQAKEGVDFLVNAIKDGRMPKAALTLDGEGGRRHFQAGKLLFHRQWPYQYGLANTDDGSSKVVGKFAVAPIPGPNGPGAANLGGHNYAISAFAKNKATALDFIKYMADEKQQKANSLATSQAPTVAALYDDPEMIKKYPYLPTLKAAIQNAKSRPVVVRYGDVTAAIQGSVYDALGGKTPTGQAMTDLQNKLTELTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XJD9</accession>
    <name>A0A1H5XJD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_103273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG11585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG11585">
        <property type="protein sequence ID" value="SEG11585"/>
        <property type="gene ID" value="SAMN04489712_103273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="648"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG11585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="683" mass="73641" checksum="B261304959577B6D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XX07</accession>
    <name>A0A1H5XX07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEXXH motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG16329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG16329">
        <property type="protein sequence ID" value="SEG16329"/>
        <property type="gene ID" value="SAMN04489712_103452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG16329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="614" mass="65318" checksum="AA290DA920820DA4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YP76</accession>
    <name>A0A1H5YP76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG25919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG25919">
        <property type="protein sequence ID" value="SEG25919"/>
        <property type="gene ID" value="SAMN04489712_104112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG25919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="518" mass="56765" checksum="E6C56BE714282DA3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YSK0</accession>
    <name>A0A1H5YSK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Replication-relaxation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG26642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG26642">
        <property type="protein sequence ID" value="SEG26642"/>
        <property type="gene ID" value="SAMN04489712_104143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025855">
        <property type="entry name" value="Replic_Relax"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13814">
        <property type="entry name" value="Replic_Relax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG26642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="33513" checksum="591D4596C7ABBE99" modified="2017-01-18" version="1">MTRSSKTANRMRGAHGHRPRMSPELIADLAYRLTGRDRKILELVWEHRVLTTDQLTAIFFPSLVRARQRLRQLRELFALVRFQPWTSVGTSPQHWILGPAGAHVLAAQRGISLRNLGYRQDNAMAISLSPKLGHQVGVNDFFAHLHAYAGRRGDGTALAEWWSERRCASLWGDLAHPDAFGRWTEPQEIGPSATIDFFLEHDTGSEPLSRVAAKLTGYAALAESTGIATPVLFWLPSAAREANLHEVLGTPDVPVATAVHTPRAAVDGPAGPVWLPAGTTGPRCRLVALADAWGPHDRQHGTGPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5YWE4</accession>
    <name>A0A1H5YWE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG28401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG28401">
        <property type="protein sequence ID" value="SEG28401"/>
        <property type="gene ID" value="SAMN04489712_104220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="227"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG28401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="342" mass="36781" checksum="D78B11CCF72E06F3" modified="2017-01-18" version="1">MESTRPEPDPVTSRTGRPAGRRRGRPTRSRARAALLTGAVLAASGLLPAAPGHADPDPSTKELTSQAHKLADRLEQLTERYNGLKVQLSQAQRAAKVAAANAARQEEALESVREKVGSLAATSYMQNGVDPAVALATGGDPQALLDQAATLRYFAEQDGTKVQGLVQAMQAAQRARKSAEDRAEQVTKLRTQLDDQREEVTELYEKIRGKIVKRDPSALADLPVIGTGKAAQALRYAMGKLGRPYVWGAAGPSTFDCSGLTMWAYKQVGINLPHYTGSQWNAGTHISRSQLKPGDLVFFHSDLHHMGMYVGDGKFIHAPQTGDVVKISPLDGRPYAGAVRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z5T2</accession>
    <name>A0A1H5Z5T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_104354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31370">
        <property type="protein sequence ID" value="SEG31370"/>
        <property type="gene ID" value="SAMN04489712_104354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG31370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="96" mass="9981" checksum="B3C4BB8F9D098D55" modified="2017-01-18" version="1">MTVDELTAWRLRCRVCQVTSGGLTWVKLLGLRGGPSCSSCGAKEVTAQEPASGAAVVFPRPLAPLGELWRCCNCGGTGLDAYGDTCPHCAGLGHCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z6F6</accession>
    <name>A0A1H5Z6F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_104385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31931">
        <property type="protein sequence ID" value="SEG31931"/>
        <property type="gene ID" value="SAMN04489712_104385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="329"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG31931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="365" mass="39688" checksum="459B19DF1400201F" modified="2017-01-18" version="1">MGVEIRVEGLTKSFGRQVIWQDVSLTLPAGEISVLLGPSGTGKSVFLKSLVGLLKPDRGNIWIGDRNLPYLPEGQLYDTRKLFGVLFQDGALFGSMNLFDNIAFPLREHTRKSESEIKRIVLEKMEMVGLLGAEKKLPGEISGGMKKRAGLARALVLDPEILLVDEPDSGLDPVRTAYLNQLIVDLNAQINATFLIVTHDINTARTVPDNIGLLFRRELVMFGPREMLLSSEEPVVRQFLNARRQGPIGMSEEKDVSELEAEARMGADPGRLPPIPPQLMPSDGRVRPAQSPPGAWLRAHGVQPPPGSFVDETGRNWIEEWPRYVATMGPVGAAAGPGQAPPPGPPPQHPHGPKPGMPPAGGPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z711</accession>
    <name>A0A1H5Z711_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rplA</name>
        <name evidence="11" type="ORF">SAMN04489712_104380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG31830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG31830">
        <property type="protein sequence ID" value="SEG31830"/>
        <property type="gene ID" value="SAMN04489712_104380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SEG31830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="236" mass="25503" checksum="885841F63758F57D" modified="2017-01-18" version="1">MKRSKTYRRNTELIDRDRLYTPAEAVGLARKTSVTKFDATVEVALRLGVDPRKADQMVRGTVNLPHGTGKTARVLVFAGGAKADEAREAGADYVGTDDLIERIQGGFLDFDAVVATPDMMGKVGRLGRVLGPRGLMPNPKTGTVTMDVAKAVSDIKGGKIEFRVDRHANLHFIIGKASFDDRQLVENYAAAIDEITRLKPAAAKGRYIKKAAITTSMGPSIPVDPNVVRNLTAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZDM5</accession>
    <name>A0A1H5ZDM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_104508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG34623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG34623">
        <property type="protein sequence ID" value="SEG34623"/>
        <property type="gene ID" value="SAMN04489712_104508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG34623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="209" mass="22438" checksum="A7DFCD9EF8370858" modified="2017-01-18" version="1">MTTVVLVDDHQMFRTGVKAELGDGIEIVGEAGDVDEAVRVISATRPDVVLLDVHLPGGGGIEVLRRLSGAVPSRFLALSVSDAAEDVIGVVRGGARGYVTKTISGPELTDAIGRVAEGDAVFSPRLAGFVLDAFAATDAPAVDPELDQLTQREREVLRLIARGYAYKEIAKELFISVKTVETHVSSVLRKLQLSNRHELSRWAAARRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZEM9</accession>
    <name>A0A1H5ZEM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_104472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33836">
        <property type="protein sequence ID" value="SEG33836"/>
        <property type="gene ID" value="SAMN04489712_104472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG33836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="39712" checksum="45D1AA01A30D9735" modified="2017-01-18" version="1">MENNHSFRQAVGQPVSDRMRELLARAAQDHVHDQRSHGQVLDELRRRMEGVEWLLREVRERELGGLTGRLDGVLGQLDRLSGRPPQWAEGLAEHIDAVAERAEPVAELPALRADVTVVAEQVDEGLSRLQGVLDGTRDVQATAEQAAQRMDEMARRLDRLQGSMEAASVRFNRIDRALAELGHRGERLEHSVRQITVRVERSCAELAERVEHGLDAVDGRVEGVGGRLAGLDGRLEGFSGRLAEFSRRFEDGHDDVRRRIEGIHEEVARRVDGALADLTARVDVVSRRVESVHGDVTRRVEAVHDEIGKQVTGVHGDVAAQVGVVREDVLRRLATLEKTMLALAEVLLRPRQEDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZUG2</accession>
    <name>A0A1H5ZUG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG40138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG40138">
        <property type="protein sequence ID" value="SEG40138"/>
        <property type="gene ID" value="SAMN04489712_10517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG40138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="216" mass="24160" checksum="2FC236CC6E8C856B" modified="2017-01-18" version="1">MRHMAFDRPVLRGTGGLTFWRLLGTGRGRSMSLGADLRRWALFAVWDGEAALEDFLGCSPVAARWRAQAVESWHVRLAPRVWHGRWGGSDPLGGTRSRWRDDAPVAVLTRASIRPSRLMAFYRSVPEVDGALGRQDGCLASVGIGEWPLARQATFSLWRDDAAITRFAYRGAAHRGVIARVHAERWYSEELFARFVPYGSEGTWDGRDPLRPRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A2K4</accession>
    <name>A0A1H6A2K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SAMN04489712_105139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG42454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG42454">
        <property type="protein sequence ID" value="SEG42454"/>
        <property type="gene ID" value="SAMN04489712_105139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG42454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="380" mass="42301" checksum="D12FC424EF44205C" modified="2017-01-18" version="1">MGREIFTEEHEAFRDMVRSFIEKEIAPYHEQWEKDGIVSRDVWLAAGRQGLLGIEVPEEYGGGGIDDYRYYMIFNEELARAGVHGPGFAVHNDINGAYLLKLCNEEQKRRWLPGYCSGEIITAIAMTEPAAGSDLQGMKTTAVRDGDHYVLNGSKTFISNGILSDLVIVAAKTDPSAGARGVSLLVVERGMEGFERGRNLDKVGMHAQDTAELFFDNVRVPKENLLGEEGMGFIYLMQNLARERLSIGATALAGAETAFEQTLEYCKTREAFGRPIGKFQHNRFTLAEMKTELTVARAFTDQCVLKESEGELSAEEAAMLKYWNTELVKTVVDRCVQLHGGYGYMTEYPIGKAYQDVRIQTIFGGTTEIMKEIIGRSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A4G4</accession>
    <name>A0A1H6A4G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG43242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG43242">
        <property type="protein sequence ID" value="SEG43242"/>
        <property type="gene ID" value="SAMN04489712_105186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG43242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="256" mass="29122" checksum="56FDDFAB09A05097" modified="2017-01-18" version="1">MSYQAKFRVWRGDDGDGELVDYTVEVNEGEVVLDIIHRLQATQAPDLAVRWNCKAGKCGSCSAEINGMPRLMCMTRMSTFTEDETITVTPVRTFPVIRDLVTDVSFNYEKARQIPSFDPGDTKPGEFRMMQQDVQRSQEFRKCIECFLCNNVCHVIRDHEENKPQFAGPRFLMRIAELEMHPADESDRRQIAQDDHGLGFCNITKCCTEVCPEHIKITDNALIPMKERVAGKRYDPLVWLGSKLGIVKKGQDTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AAE3</accession>
    <name>A0A1H6AAE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45713">
        <property type="protein sequence ID" value="SEG45713"/>
        <property type="gene ID" value="SAMN04489712_105319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG45713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="173" mass="19408" checksum="8D5289A785C92E1D" modified="2017-01-18" version="1">MNTSEAADKLRGWFTGRLPQDWFAGPPEVVVDREEVSVIGTLAPPPAAEGMSDAERTAMLAGHVQRFREETRERRIAIAREAEHRFGHKVSWGVECGGLREMFTTLSVPVMTRLRQPERRVLDTLVEAGVARSRSDALAWCVRLVGRNADEWLAELREALQHVERARAAGPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ABU1</accession>
    <name>A0A1H6ABU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized membrane protein YckC, RDD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_105332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG45921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG45921">
        <property type="protein sequence ID" value="SEG45921"/>
        <property type="gene ID" value="SAMN04489712_105332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="74"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG45921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="227" mass="24242" checksum="FDF41C3C378F89EE" modified="2017-01-18" version="1">MTQPPHGPSPDEQPWKPPHEQPHPGWQPGPYGGGRQPPPYPGPYGGQPPPYGGYGGLPGYPGEPGGYVDPAAGLASRWARLAAAIVDLVLLTIIIGLVTFPFINYRRIIETGNTGAVPAGQWAANFVSVVIAFLYYWLLTYKWGQTLGKKLLGIQVVRAADGGAVTQGQAVGRSAFFTVLGGLCGCIGFIDVLWLLWDPRRQALHDKVAQTVVRKVPPGGPDPYAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AD87</accession>
    <name>A0A1H6AD87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_105353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46240">
        <property type="protein sequence ID" value="SEG46240"/>
        <property type="gene ID" value="SAMN04489712_105353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="11"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG46240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="454" mass="50252" checksum="44DB6B7239219494" modified="2017-01-18" version="1">MPATNARKTTRVLIVGGGYVGMYTALRLQRKLRREISRGQVHITVIDPQSYMTYQPFLPEAAAGNLEPRHVVAPLRRVLNRCTILNGRVLSIDHAARRARVRVVGAELMADGERELTYDRLVVALGSVSKTLPIPGLSECGIGFKTLGEAIYLRNHVLAQMDIAASSEDERVRRRTLTFVFVGGGYAGVEALGELEDMARDACKWYPAITPGDMRWVLVEATGRILPEVGEEMGRWTVETLRRRGIEVKLGTQLKSAEDGTIVLSDGEEFESGTLVWTAGVKPNPVLAATSLPLDERGRLKVTAELVVEGVEGVYSAGDNAAVPDLTKPGQYCAPNAQHAVRQARRLADNLVADLRGQPRQPYRHAYVGSVASLGLYKGVANVYGTKLRGFPAWFLHRTYHLSRMPTINRKARVTADWTLSTFFRREIVSMGEIHRPREEFALATGRREASLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AEK9</accession>
    <name>A0A1H6AEK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_105385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG46822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG46822">
        <property type="protein sequence ID" value="SEG46822"/>
        <property type="gene ID" value="SAMN04489712_105385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="PTHR10605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransfer_1" evidence="2">
        <location>
            <begin position="35"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG46822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="289" mass="32833" checksum="2C38EF0BCA01EC30" modified="2017-01-18" version="1">MISRRDAPLWVKQTGRAVSRGAGRLTAGTRMLPGFLMVGTQRGGTTSLFRSLAEHPGIVQPNFHKGVHYFDVNYHRGPTWYQGHFPTRAAARKRAAGTTDRPLAFESAGYYMHHPLAPGRIAADLPGVKLIVLLRDPVERAYSAHKHELARGFETEPFERALELEPERLAGEVEKMRADDAYLSHSHRHHSYVNRGQYADQLEVLFELFGQDRVLVLFAEDFFAEPEPHYDRVIDFLGLPHWRPASFERHNARPSSPMPATVRARLSAHFEPYDEKLAALLGEVPAWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWY5</accession>
    <name>A0A1H6AWY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53108">
        <property type="protein sequence ID" value="SEG53108"/>
        <property type="gene ID" value="SAMN04489712_10673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG53108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="608" mass="67385" checksum="16C8C60FAE632948" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AX54</accession>
    <name>A0A1H6AX54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53138">
        <property type="protein sequence ID" value="SEG53138"/>
        <property type="gene ID" value="SAMN04489712_10675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG53138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="799" mass="87741" checksum="085A854BFD6171F8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B344</accession>
    <name>A0A1H6B344_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein E (SpoIIE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55273">
        <property type="protein sequence ID" value="SEG55273"/>
        <property type="gene ID" value="SAMN04489712_106218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="166"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG55273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="379" mass="41006" checksum="C4396579204CAD29" modified="2017-01-18" version="1">MLGTVPEMLQRLVHLLPPRVRAFLRRIPVLVRFYQWLRRGRLTRERYMFVVLALVAVGLGFSATWSEAWAPSGALVLTVLAGGLLLRVRSLVALLGVVAVMLGYDMWQLSVAKVGPGMIATVVITAVLALTLARTRQQLGVQGLRGEYMLLELRDRLRRQGEMPPLPPGWGAQVVLLQAGGSSFGGDFVVSSCDGKTLEVALVDVSGKGVDAGTRALMLSGAFGGLLGSIQPDRFLPSCNDYLHRQRWDEGFVTAVHLVLDLTTGDYVVESAGHPPTAQFDSTVGTWQVNSAKGVVLGVVPELRCEPERGTLRSGDALLLYTDGLVEAPGQDLDAGIDRLLTEAERLVPQGFGKGAKELVETMAAARDDDCALVLIWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5M8</accession>
    <name>A0A1H6B5M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_106230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55416">
        <property type="protein sequence ID" value="SEG55416"/>
        <property type="gene ID" value="SAMN04489712_106230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG55416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="468" mass="49594" checksum="9E13E373FF812AB3" modified="2017-01-18" version="1">MVEQAAAIRARDLSPVELTDHYLDRIERLDAQVGAYVTVTAEAARDQAARAAERVLRCADPVTLPPLHGVPVPIKDLNMVRGVRMMLGSAAFDDLVGFADDTVVVRLREAGTVLLGKTATPEFGLPCYTETDVSPPARTPWDLTRSAGGSSGGAAAAVAAGLAPAAQGSDGGGSIRIPSSVCGLFGIKPTRGRISHGPINPDLFGLATNGPIARTVRDAAALLDAMHGPEPGDLYTAPPLPPGETFAGYAGRDPGRLRIARTITPAVPGAEVHPDCVAAYEKTSVLLEELGHEVVELPVLFGPELVPDFELLWGVMATLTPVDPARGDRLLPLTRWLRERGHAVTGPELLMAQARFQAAMRAAFPVMNGFDAILSPTLAQPPMPVGHFHDAEPAENFHRQTRFTPFCAVYNVSGQPAVNVPLHWNADGLPIGVMLAGRLGGEGTLISLSAQLEAAHPWHDRRPPIWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6D5</accession>
    <name>A0A1H6B6D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Poly(A) polymerase central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_106307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56368">
        <property type="protein sequence ID" value="SEG56368"/>
        <property type="gene ID" value="SAMN04489712_106307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004652">
        <property type="term" value="F:polynucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043631">
        <property type="term" value="P:RNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MJ1316" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="7">
        <location>
            <begin position="123"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PAP_central" evidence="9">
        <location>
            <begin position="692"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG56368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="955" mass="102597" checksum="F7FA6E4E8EAED242" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6N0</accession>
    <name>A0A1H6B6N0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG56501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG56501">
        <property type="protein sequence ID" value="SEG56501"/>
        <property type="gene ID" value="SAMN04489712_106317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="2">
        <location>
            <begin position="34"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG56501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="170" mass="17511" checksum="A90C3750E05560AF" modified="2017-01-18" version="1">MRRQLENLIERLTKVTVQPPADGRTPAVPGASVLGELHALRHRLPGLTGSLVASADGLPVAADLPPQVEPAGMAALTTSGLALSQRIALTVQDGGFQEVVIRATGGYVVTYAAGLVASLTVLAGPGVNVGRLHLESRPAAARIAALLEEAGAAAPRPPPAEGPRHRRNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B6S1</accession>
    <name>A0A1H6B6S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55917">
        <property type="protein sequence ID" value="SEG55917"/>
        <property type="gene ID" value="SAMN04489712_106270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="301"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG55917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="393" mass="40618" checksum="B127024BE99A26CB" modified="2017-01-18" version="1">MNSGVVVQEDALERIHSCGGVLVRAAVRGLSGFFLLLCLLLVGPSPVRLGLVVAAGVAAFGAVSVRGTAIWTVAASGASVVVTVLLVQPSAPALSPAMVVEGPGLVVLLVRMVWRAPAHRVPLLAPLPALALAVMPLRASPMFAVAASIPLAGLLVTAVCIGLYLRALDARRARTITDARRDERLELARDLHDFVAHHVTGIVVQAQAARFAAGSGAAQTPEQLDAMLGGIEKAGTEALTSMRRMVGLLRDDGDTSPDGHAHGGRTRPVGDLDRLEELVAGFNDPPASLVVDPGVRGLPPEVATSAHRIVQEALTNARKHAADATAVHVSVRRFPEGVEIAVRDDGRGGGRRLPGGGYGLTGLAERVHALGGRLHAGPSPVGGWEVVAFLPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BEH7</accession>
    <name>A0A1H6BEH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:solute symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59209">
        <property type="protein sequence ID" value="SEG59209"/>
        <property type="gene ID" value="SAMN04489712_10754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG59209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="575" mass="59883" checksum="D8CE68C0616035CF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BFZ6</accession>
    <name>A0A1H6BFZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component system, LytT family, sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59257">
        <property type="protein sequence ID" value="SEG59257"/>
        <property type="gene ID" value="SAMN04489712_10757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="286"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="405" mass="43375" checksum="FCF1E659F00B65AC" modified="2017-01-18" version="1">MDVALAVVAAVAVTGGLAAVPWWRGRRELGSPADRATFQTLHTASLAAPPLRAGLTEQGAQKAARHLRELLGSAALAITDGERLLAWDGSGDHHAEGALAHAAGPMDSGRTEVLGPDTVACAYLDCPVKHAVVVPLTTDDRVVGTLAAYGDDVSAGLIRAAEEVGHWVDAQLQLAELDRSRTLLMEAEVRALRAQISPHFIYNSLTTIASFVRTDPERARELLLEFADFTRYSFRRHGDFTTLSEELHSIDRYLLLQRARFGDDRLRVTLRIAPEVLPVAVPFLCLQPLVENAVRHGLQDRTGPGQITIIAEDAGADAVISVEDDGIGMDPERLRHILAGEYRGAEPDGEGSPEAAGIGLGNVDGRLRQVYGDEYGLQVETATGAGTKVTLRVPKYRPGVTASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BME6</accession>
    <name>A0A1H6BME6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YjbI, contains pentapeptide repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61853">
        <property type="protein sequence ID" value="SEG61853"/>
        <property type="gene ID" value="SAMN04489712_107251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG61853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="206" mass="21782" checksum="2ECFCE9FE4926920" modified="2017-01-18" version="1">MADRKHGRPVPPTDITIRSEDWDGRDLSGHEHANVAFVDVDMTEASGRGAVFSECVFRGVRFNASTHTDAAFVNCTFVRCSFFDTAFTGCKLVGSMFDGCTYGLLKAEGGDWSFAGLPGADLRGSSFTGVRMREADLTGARCAGASFRDVDLSGAWLHKADLSGCDLRGSNLSSLDPRTAALAGAVIDPVQAIVLAGALGLEVRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BN42</accession>
    <name>A0A1H6BN42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62090">
        <property type="protein sequence ID" value="SEG62090"/>
        <property type="gene ID" value="SAMN04489712_107272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG62090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="225" mass="24425" checksum="8773CE5E22EC3E79" modified="2017-01-18" version="1">MVTFPDPFDDPPWAMQLAVQVEKAAPPVHGAVCEAAAMAVVRLLTDPRSTEPEGEWHARVRRWESGRIRKVARRARGVRWREAQELPGVTVDHDGARVRAFVPGPVDEVPPQLAKLQVAGLDLVREESKPPPEPPYAALALNPGVTMSTGKSAAQSGHAAQLLLRQGSRRDVAAWLAAGARVHLADDVPWRECVRQATAVVRDGGFTEVPPGTMTAIAWLVTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BUE7</accession>
    <name>A0A1H6BUE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64252">
        <property type="protein sequence ID" value="SEG64252"/>
        <property type="gene ID" value="SAMN04489712_1087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG64252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="182" mass="18931" checksum="A28DD0FC76ADEC4C" modified="2017-01-18" version="1">MGIQGPQGPEDSPGEERSTLGREAGNADRRASGGAGGAGTAFGGADTASGGEGGAGAEPSGGVYEWYTRGLELLGAGSPAAAVQLLQRAAEAEPSSRSIREALARAQYGSRRFADAADSFRWIVEDNPSEDYALFGLGLSLSRLGDFEEAVEHLALAVAMRPENKHYTNALRHVRATLAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BWJ2</accession>
    <name>A0A1H6BWJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgl</name>
        <name evidence="9" type="ORF">SAMN04489712_10874</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65061">
        <property type="protein sequence ID" value="SEG65061"/>
        <property type="gene ID" value="SAMN04489712_10874"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="12"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG65061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="260" mass="27276" checksum="53F98D91C2A92CA7" modified="2017-01-18" version="1">MSAPPAVLVHHDQTMLARSAAARLVTRIVDVQAARGSASIVLTGGGVGTAVLAELAASRARDAIDWGRLDLWWGDERFLPSGDPERNETGARAALLDHVPVDPARVHPMPASDGPDGNDPEAAAERYAALLRAASRPEDHGPVPSFDVLMLGMGPDAHVASLFPEMPALYDERPVVAVRGAPKPPPTRITMTLPTILAAREVWVIAAGESKADAVRLGLSEAGPVQVPVAGARGRQRTLFLLDRGAAAKLPPGLERIASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BXI6</accession>
    <name>A0A1H6BXI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein, AIM24 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_108103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG65410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG65410">
        <property type="protein sequence ID" value="SEG65410"/>
        <property type="gene ID" value="SAMN04489712_108103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG65410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="216" mass="22606" checksum="2F33354BE8219C3A" modified="2017-01-18" version="1">MPAFSPINSKMLQAPVGPGQELYSKRGAMLAYVGRVRFEPSVTGGAGIGGAIGRAMAGESAPLMHVTGQGSVMFGHGGLYVNVIELQGDTLYVEADRLLVYDASLQSGTMFLGEQGGLSGVIRGQMTGQGLFTTTLSGHGSVAVLSHGGVIELPISPQRPIYVDPQAYVAHRGQVTNRLKTSMGLRDMVGRGSGEAFQLELSGHGIVYVQASEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C0Z5</accession>
    <name>A0A1H6C0Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_108206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66592">
        <property type="protein sequence ID" value="SEG66592"/>
        <property type="gene ID" value="SAMN04489712_108206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG66592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="264" mass="28134" checksum="F4F39743C61216D9" modified="2017-01-18" version="1">MTHTAPTTDEGLAAPGAGDLAARAQQITKVYGSGDARVVALDGVTLGIPRGRFTAIMGPSGSGKSTLMHCMAGLDSIDSGTVLIGDVELNRLDDKRLTRLRRDRVGFVFQAFNLVPTLTALENITLPMDIAGRKPDRQWLDRVIDTVGLRPRLGHRPSQLSGGQQQRVACARALASRPEIIFADEPTGNLDSRSGAEVLGFLRDSVREMGQTIVMVTHDPAAAAYADEVVFLADGRIVDTMAAPTAEKVLERMKGFDLPGATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C825</accession>
    <name>A0A1H6C825_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase expression/formation protein HypD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_10919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypD family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG68785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG68785">
        <property type="protein sequence ID" value="SEG68785"/>
        <property type="gene ID" value="SAMN04489712_10919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11750">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG68785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="375" mass="41211" checksum="A86C9833B5FF7B87" modified="2017-01-18" version="1">MRFVDEYRDADRARVLAAGIAALCEPGRHYKFMEVCGGHTHAIYKHGLEDYLPEAVQLVHGPGCPVCVIPMGRVDDAIAIARNPDVILTSFGDMLRVPGGHGSFLDAKAAGADIRMVYSPLDALKLARRNPDRRVVFMAIGFETTAPSTAMTVLRAAAEGVQNFSVFCNHVTIIPAIKAILDSPDLRLDGFIGPGHVSTVIGCRPYGFIPRDHGRPLVCAGFEPLDVLQAVHMLLRQLAEGRAEVENQYTRVVPWNGNHRALEAINRVMELRPYFEWRGLGFISHSALRMRDAYAAFDAERIFQVPGVRVADPKACQCGEVLKGVLKPWECKVFGVACTPETPIGTCMVSAEGACAAYYNFGRFTRQRTRKASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CA56</accession>
    <name>A0A1H6CA56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hemolysin, contains CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_10991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69515">
        <property type="protein sequence ID" value="SEG69515"/>
        <property type="gene ID" value="SAMN04489712_10991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="281"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG69515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="337" mass="35729" checksum="0A610EF493423A55" modified="2017-01-18" version="1">MDPLTAIAVTVLLLIGNGFFVGAEFALVAARRPRLERAARAGSRPAAAAVAGIRELSLMLAGAQLGITMCTLGLGVVTEPAFEKVLAGPLHELGAPEGASHAVALTVALTVVTFLHMVIGEMVPKSWAISHPERSALILAMPFRAFARVARPILAVMNGLSNGFLRLIGVPPRDALDSHTDPQRLGHLLGESRRLGLIDRRDHDLLDRVITIRDAAIGDLTVPADRVTTVPSAAGPLDIRRAAEASGHVRTLVRDEDGAILGVVHVRDAIIARNGQRAADMCYPVPRLDAQTSVLDAATRLRRDRAQLALVTESDGSIRGIVSMDDLLGQLLAANPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCA7</accession>
    <name>A0A1H6CCA7_9ACTN</name>
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        <submittedName>
            <fullName evidence="4">Sortase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70538">
        <property type="protein sequence ID" value="SEG70538"/>
        <property type="gene ID" value="SAMN04489712_109178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009294685" evidence="3">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG70538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="201" mass="21183" checksum="0379638A159B29C9" modified="2017-01-18" version="1">MITFCGIGITLLGILAITVVVRIPAVAARPPVPQAAASPSPSPVRELGPADGLPPSRPVTLEIPRLQVRTALLTLGRNADGSLEVPSAAHVQRAGWYRYGAAPGSPGPAVIAGYVDSAAGPAVFHRLGELVPGDHVTVLRRDRRVAVFRIDRVELVEQGGFPTRKVYGKVSYPGIRLVSIGGSSGRYPQRVIAYGRLVQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CCD9</accession>
    <name>A0A1H6CCD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyisoprenoid-binding protein YceI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70679">
        <property type="protein sequence ID" value="SEG70679"/>
        <property type="gene ID" value="SAMN04489712_109191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG70679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="182" mass="19756" checksum="6BF46BCEE2A1DB12" modified="2017-01-18" version="1">MSLAAVAPGLTAGTWNIDPSHSEVTFTIRHLMSKVRGTFTEFSGTVVIADQLSASSANVEIKMASVDTRNADRDNHIRSAEILDIAAHPTMTFRSTGLRVEGGDHYLDGELTIKGVTRPVTLEVEYNGVGEDPWGGFRAGFSAKTAINRKDWGVEFNVPLQGEKVLLSDKVDIQLEVQAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CDI9</accession>
    <name>A0A1H6CDI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Permease of the drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_109226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG70968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG70968">
        <property type="protein sequence ID" value="SEG70968"/>
        <property type="gene ID" value="SAMN04489712_109226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="148"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG70968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="338" mass="34335" checksum="F28D0675C6A3D578" modified="2017-01-18" version="1">MSGRGWALFALMSVIWGIPYLMIKVVVEGVSVPVLVFARTAVGAAVLLPLALRGGGLAGLRPYWRPLAAFAALEIIVPWWLLSDAERHLTSSMTGLLIAASPIVAAVLSRLTANAERLSAVRWAGLAVGLAGVAVLAGPQLHGGAPWPIAEVLLAAACYATAPLIAAHWLRDVPALPMTAACLGLAALVYTPPAAMTWPDALPAGRVLAALAGLAIVCTALAFIVFFALIREVGTSRALVFTYVNPAVAVTAGVLVLNEPLTATILASFALILGGSVLATASQSGDKNETTTASQADGNEATASQAGENETAASQVGDGNEAGAARQAPAPERAPAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CF22</accession>
    <name>A0A1H6CF22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71472">
        <property type="protein sequence ID" value="SEG71472"/>
        <property type="gene ID" value="SAMN04489712_109274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="64" mass="6695" checksum="D3D6F1900DF0FC6B" modified="2017-01-18" version="1">MQVARKALGRRCRSARDLGMSTAEYAVGTVAAAAFAGLLFKLVTSSEVKSLLLGIIRDALQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CL93</accession>
    <name>A0A1H6CL93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73216">
        <property type="protein sequence ID" value="SEG73216"/>
        <property type="gene ID" value="SAMN04489712_11084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="336" mass="34555" checksum="EAB36C43E8B5F036" modified="2017-01-18" version="1">MDIPRWALPVAALATAGMLLTACGGESPKQNVAAGSKQTAEPLEDPSADPSADVEATSLEVADDPELGKIVVDGEGNTLYRFDKDTADPPASNCNGACAKAWPPVTTSDDAAVKGLDADLVGTVKRSDGTEQVTLNGWPLYRYAKDESPGDTRGQGVQGTWFVSTPTGKKAGATPSPAPRNQNNGGGNGGRWTGKTTLKAVQNDRLGAIVVDGQGRTLYRFDKDVPKSGKSNCNGACAKAWPPVKFTANMTLTGIKGKVGNIMRADGVCQATLNGWPLYRYVKDQQAGDILGQGVQGTWFVSDPNGRKALGAGDADGGGNGGGGGGYGNGDGGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLX5</accession>
    <name>A0A1H6CLX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_110172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73940">
        <property type="protein sequence ID" value="SEG73940"/>
        <property type="gene ID" value="SAMN04489712_110172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="105" mass="11744" checksum="77189D9840359A67" modified="2017-01-18" version="1">MITWRKSSYSGSTSTQSDCVELTRLTGGIGVRDSKTPKARHLSLSLQSFATLVARVKRDELSVSARPLVTALEEYRQRREPAHVLDLADETGRDHRNLLDRLGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CRP4</accession>
    <name>A0A1H6CRP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_11156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75558">
        <property type="protein sequence ID" value="SEG75558"/>
        <property type="gene ID" value="SAMN04489712_11156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="9882" checksum="397C2B6FE052E91A" modified="2017-01-18" version="1">MNLTDATRMIMAESAAFPELMRAARDVYDELSAGRRVHYTALNWILREAGRKDLYGVLRQKHGTGAFEDMVTALCREIDRQAPVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CSM7</accession>
    <name>A0A1H6CSM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_111104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000011">
        <property type="protein sequence ID" value="SEG75974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG75974">
        <property type="protein sequence ID" value="SEG75974"/>
        <property type="gene ID" value="SAMN04489712_111104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG75974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="103" mass="11565" checksum="40621A380A1C2A37" modified="2017-01-18" version="1">MGTFRFRALVTIDPAAARTWDRSSAIRHLVIRVHRDEPERICFFDAVLSTDDQEPLVPGDTDHVVTMTLTDETALDVLAPGEHFELWGHGEAGHGVISRRVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D0S5</accession>
    <name>A0A1H6D0S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein, DUF427 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG78405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG78405">
        <property type="protein sequence ID" value="SEG78405"/>
        <property type="gene ID" value="SAMN04489712_11273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG78405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="125" mass="13979" checksum="DFFB42450A77C07A" modified="2017-01-18" version="1">MYDERPDYRVELLARTNAMTAWLGETRLAHSDACLIVDEQDHGLVVYFPRDAVDFSRLEPIDRRTVCPFKGQAVYWRASGGAGPGVAWSYPEPFPQVARLAGYVAFDQDAVRVTIGTGRFTGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2A5</accession>
    <name>A0A1H6D2A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type VII secretion-associated serine protease mycosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_112210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79400">
        <property type="protein sequence ID" value="SEG79400"/>
        <property type="gene ID" value="SAMN04489712_112210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009295500" evidence="6">
        <location>
            <begin position="26"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="54"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG79400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="436" mass="44477" checksum="B5B131AE60FD8B69" modified="2017-01-18" version="1">MVRRLIRVAAATLAIALAGAPTAAAEAVPRPNINVQWWFDSWAIEQLVWPATKGRGVTVAVIDTGVNAQLPDLQGVLLPGKNFLGGGNVVRRDTDEEKFGHGTGMISLIAAQGGRTGFVGLAPEAKVLPIVANTGEDTIGPAVRYAADQGAKVINISKGASAGNIECPPGLQAAVVYAAKKDAIVVASAGNSGNLSNFPEYPASCPGVVGVGAIDNQGAPWEQTQRQDYVVMAAPGVGISAISRDGRVWGNGEGTSQAAALASGAFALVRSRFPDMSAREVVQLVTNTTVDVGPKGRDDMTGFGAISLRRALREKVPASAPNPVYERLDKVMAQSSPGSSGAPSSADDGDDGGSGNLTLILVVGLVLVGIAVVGVPISIARDRKKKRGRDQPPPPGGGPGTPPSFGAPPGGQPPYTQAPYGPPSGPQPPYPPHRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D2E4</accession>
    <name>A0A1H6D2E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_112157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000012">
        <property type="protein sequence ID" value="SEG79033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG79033">
        <property type="protein sequence ID" value="SEG79033"/>
        <property type="gene ID" value="SAMN04489712_112157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG79033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="91" mass="9628" checksum="7B8478BF9AC8EB43" modified="2017-01-18" version="1">MTRGLSPAEIRSLPVTIDLVTAGRALGVGRTKAYQLARAGRFPCRVLRIGRSYRVATADLLAVLGLPAQGDPAPFGRAMEDGRPSQHGGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D459</accession>
    <name>A0A1H6D459_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl diphosphate synthase, type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80112">
        <property type="protein sequence ID" value="SEG80112"/>
        <property type="gene ID" value="SAMN04489712_11316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="346" mass="35764" checksum="B469EE61FDEE0A79" modified="2017-01-18" version="1">MATTERTDGRPAGQVLAWARELVDPALHTAVDTLPSPVRRIAGYHFGWWDELGRPLQGAGGGKALRPALALLAAEAAGGTADAALPAAVAVELVHNFSLLHDDVMDGDTTRRHRPTAWSVFGANTAILTGDALLALAADVLAVPGNPDPQGTQRMLAATVQDLVAGQLADLVMEERHDITVRECLGMAEGKTASLLGCSCALGAAFTGAAPDRVAALRGFGARLGLAFQIADDLLGIWGDPAVTGKPVHSDLRNRKKTLPVVAALCSGTAAGQELAALYRRADPPTGAELAHTMTLIERSGARAWCEERAGALLEDALGALSSAGPGGRAAGELAALARLAVRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5H1</accession>
    <name>A0A1H6D5H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty-acyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_113114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80617">
        <property type="protein sequence ID" value="SEG80617"/>
        <property type="gene ID" value="SAMN04489712_113114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="438"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG80617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="530" mass="55710" checksum="3748DC2A7D4B1089" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D5N3</accession>
    <name>A0A1H6D5N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000013">
        <property type="protein sequence ID" value="SEG80374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG80374">
        <property type="protein sequence ID" value="SEG80374"/>
        <property type="gene ID" value="SAMN04489712_11370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG80374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="121" mass="12465" checksum="9818C339B6410667" modified="2017-01-18" version="1">MTEPLATVIIVAALVIAGYGLLAALRDRPMDRLHLAGLTVVEALLLAQAVLGLVKVAGDEGPAETATFVGYLLGILLIPPAGAGWGLLERSRWGPAVIVVAGLAVAVMTVRMNQIWSGTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6D9F2</accession>
    <name>A0A1H6D9F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_114147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000014">
        <property type="protein sequence ID" value="SEG81802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG81802">
        <property type="protein sequence ID" value="SEG81802"/>
        <property type="gene ID" value="SAMN04489712_114147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG81802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="181" mass="19748" checksum="4719BBE3503EB097" modified="2017-01-18" version="1">MRAELLAHLREEKVEQPAADRIRRIVGKAISQAEKAQTALIASRVPAEAVARMLALIAQSADPGTEEDQAGTEDGALFDAEEVTGVDLFAKIREEPGNVSVKTIEKEVFKLRSISAIGLPDGLFADVAPKVLQGWRARVSAEAPSHLRVHPHDIKARAGSGMKDWRPPYSITCRTDRCRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DCE2</accession>
    <name>A0A1H6DCE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_11514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000015">
        <property type="protein sequence ID" value="SEG82355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG82355">
        <property type="protein sequence ID" value="SEG82355"/>
        <property type="gene ID" value="SAMN04489712_11514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="99"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG82355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="332" mass="35621" checksum="EFDC66458C9C48D9" modified="2017-01-18" version="1">MTPSSSSSRADRMPPPPFDPELAAALEVIREHVPPSIRLETLDTMRQLRRQLGPSDEDLRRDGAFDVTERRVPGPQGAPDVSLLICRPTGATAPLPAVYYVHGGGMIMGDNRTGIEEPLDWARELGLVLVSVEYRLAPDHPHPAPVEDCYAGLVWTAGNAAELGIDPDRLIVAGTSAGGGLAAALALMVRDRGGPTPAGQVLLCPMLDDRNETPSSHQMEGLGIWDRNSNDTGWTALLGESRGGPDVSPYAAPARAEDLSGLPPTFIDVGSAETFRDEDVAYATRIWQAGGQAELHVWPGGFHGFDMLAPHAALSQDARAARLRWLRRLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DE67</accession>
    <name>A0A1H6DE67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83727">
        <property type="protein sequence ID" value="SEG83727"/>
        <property type="gene ID" value="SAMN04489712_11656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="270"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG83727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="394" mass="40849" checksum="F08CDFA51ED8F091" modified="2017-01-18" version="1">MSRQAVIVSGARTAVGTAFRGSLVDVDALELGTKAVAEAVRRSGIPPELFDDVVMGESLYGGGAIGRYAAIEAGLVNAPGIAHNRHCASGLSTLQTAAASVIAGMDRVVVAGGVQSSSTMPRTGRRIPGTDDWEEDWLAPSHRETPDAPIRDMTVTVGWNTAAKAGLTRAEMDAWAYRSHRRAVAGIDDGSFAEEIFPIEVTRRDGTACTFAVDEHPKRNSTLDKLASLKPLHPEIEGFSITAGNSAGVNDGAAAVVVTDRSFAEEAGLRPLAVVRSWASVGVPPADTGLAPQRAVPKALDRAGLSVADISLWEINEAFASVSVAATRALGLDEDRVNVLGSGCSLGHPVAMTGTRMVLTLIHELRRRGGGFAVAAMCAGGGMGTAVVLEVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DEX9</accession>
    <name>A0A1H6DEX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] synthase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_116106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83938">
        <property type="protein sequence ID" value="SEG83938"/>
        <property type="gene ID" value="SAMN04489712_116106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="24"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG83938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="437" mass="43974" checksum="39B17D3D92B35959" modified="2017-01-18" version="1">MSADDPRDLRRRLPLSGSGPATRVAVTGMGVKSPAGSTVKDAYATVLSGKPQAVHVPAFLDLGLPVTMGCPVQGFCPEAYFSKAERRRLDRTAQLGVAAAADAVTDAGPGFAGDPARSGVYVGSGGVSLAAAMELTDHGRVDAAMPVTTVPRIMPNATAAWISIRHRMQGPCVTVTAACVSGAMAVGEAVQAIRAGRIDRAVAGGVDAPLAPAFIAAFARLGALSRRNDAPCEAGRPFDDRRDGFVLGEGAAFLTLERTEDAEKRGARIYGEITGYAVATDAAHIVGPRDDGALLARAMTTALEEAGLTPHDVGHVNAHGSSTRPGDRAEAAALRTVFGGSASGATPPIAAVKGVTGYLLGAGGAFEAAIALLCAGDGLVPPVPNFGGGADSAGLDIVTTSPRRLAPAPALSCSTGFGGQNAALVLDPVPSRWAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DFA1</accession>
    <name>A0A1H6DFA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_11699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000016">
        <property type="protein sequence ID" value="SEG83910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG83910">
        <property type="protein sequence ID" value="SEG83910"/>
        <property type="gene ID" value="SAMN04489712_11699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="17"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG83910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="485" mass="50332" checksum="DAE12EABA9648F62" modified="2017-01-18" version="1">MDDRLMHRREFFIGGAWTAPAGGDLLDVVSPSTEEVVGEVPVATAADVDRAVTAARTAFDEGPWPRMTPAERADVLARAATVLRGREAEIAAVTVDEMGCAISQAPRSQTGMVAPLFDYYAGLARGYAFEREVAAGDRAGLVTEEPVGVAAVIVPWNAPVTLAAWKTAPALAAGCSVVVKPPPEAPLSGYVLAEALAEAGVPHGVVNLVPGGRQVGEHLVRHPGTDKVAFTGSTAAGKRIMSLCGERITRVSLELGGKSAAVVLDDADVAAVVPAIVGGAMHLSGQVCGAHTRVLLPRFRYAEAVEAAAAAAAAVPVGDPHDPATVVGPLVAERQRERVEGYIALARDAGARVAAGGGRPAHLPRGWYVEPTILADVDNSMRVAREEIFGPVLCLIPYDGEDDAVRIANDSPYGLAGGVWAGDPARGLRVARRLRTGSVAINGVHPPFPHVPFGGFKESGLGRELGPEGLRSFLEPRSIGLPPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DKA0</accession>
    <name>A0A1H6DKA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_117138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000017">
        <property type="protein sequence ID" value="SEG85106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85106">
        <property type="protein sequence ID" value="SEG85106"/>
        <property type="gene ID" value="SAMN04489712_117138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="4">
        <location>
            <begin position="6"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG85106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="525" mass="57456" checksum="DD9E5CDE33C2540F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DMQ4</accession>
    <name>A0A1H6DMQ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ORF">SAMN04489712_118124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000018">
        <property type="protein sequence ID" value="SEG85986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG85986">
        <property type="protein sequence ID" value="SEG85986"/>
        <property type="gene ID" value="SAMN04489712_118124"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="72"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="313"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG85986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="423" mass="45826" checksum="2BFBA15EC5427E5E" modified="2017-01-18" version="1">MFQANPEEQESMSDLPLRAQMAVALGRTAAKMSRLAGRGDGSVIGGRIGLKLDPELLTRLARDRNLVLVSATNGKTTTTRLITAAMTPLGQVATNAFGANMPTGHVSALAAAPDAKYGVLECDEKYVPMVLRETGANVVALMNLSRDQMDRAAEIWLLAGKWRKALEAAPDSHVIANCDDPLVTWGAATAKSVTWVAAGQHWREDSWSCPECGGPLDREGTNWACRECSFARPKPDWILHGGRVTAPGGRTYELSSLQLPGRANRSNAVIALAVVARFGVEPDVALPLLGQVKSVAGRYTTVEHEGRRIRLLLSKNPAGWLEAFDVLQPAPGPVALAINAQGPDGRDTSWLWDVDYRILRGRPVWATGERRLDLAARLEAAEVEFTLVEDIEQAVMAVPPGHLDVIANYTAFQDIRTRYGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DNS7</accession>
    <name>A0A1H6DNS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG86888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG86888">
        <property type="protein sequence ID" value="SEG86888"/>
        <property type="gene ID" value="SAMN04489712_12027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG86888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="261" mass="27735" checksum="75307ED6D03D944B" modified="2017-01-18" version="1">MQGIADYDFVRSLGQGNHGEFFLAHRPDRLPVEAEYVTVKVVGGTGEDAFRRATRELKAFAAVRSPHLVTLYDAGQQAGIFYYSMEYLPGGSLASPAGPRERADYYRALACAARAAQALHDSGIVHRDINPSNILLTEDGGKLADLGLAQVLAPGVTITGMGALPSVEYTDPASLRGEPTTTAVDLWSLGATLHWFAAGTGIYGGLPVHDPLLTLRKVLSSPPKVSEDLPPKIADLVRSCLGDPSTRPTAGQLADQLDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DQE6</accession>
    <name>A0A1H6DQE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_120148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000020">
        <property type="protein sequence ID" value="SEG87518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87518">
        <property type="protein sequence ID" value="SEG87518"/>
        <property type="gene ID" value="SAMN04489712_120148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG87518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="33476" checksum="D20A698EA4E82C6D" modified="2017-01-18" version="1">MARCRAAPAHGTVGRVIEVNELTKRYGRTTAVDGLTFTVRPGHVTGFLGPNGAGKSTTLRIVLGLDDPTSGSATVNGRRFRDRPRGLRHAGALLDAGDVHGGRSARAHLSALARSNGIPRRRVAEVLAEVGLAEVARRRVGGFSLGMKQRLGIAAVLLGDPPVLLFDEPLNGLDPEGVLWVRGLFRRLAAEGRTVLVSSHLMGEMEHTADRLIVIGRGRLIAAETVPEFAARVTRPRVTVRASDPTALTALLTAEGAAVRPDGAGTLTVTGLDAARVGELAAGRGIALHELATRTASLEEAFMKLTADSVEYPAGDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT20</accession>
    <name>A0A1H6DT20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional regulator, FadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88542">
        <property type="protein sequence ID" value="SEG88542"/>
        <property type="gene ID" value="SAMN04489712_12227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="279"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG88542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="494" mass="53159" checksum="10002C16D4C3F1BE" modified="2017-01-18" version="1">MVKAGARPAPGPDDDGPLSGTGDPGRAGGSVGKLAAQVARQIEAEVIRRGWPVGEILDSEPVLRERYGVSRTVLREAARLLEHHQVARMRRGPGGGLVICAPDAEPTVRAVVIYIEYANADLRDVLHARRLIEPLVGRLVTERINERGIAALRNALAAEIPPKDPGGWADNLFHAMLSEMTGNPVLQLFTDVLEQLAFRYVSLAARIPLAEVLRFTEISYRQHAEIVDATVAGDAPRAQIKLIEHLDEVAEWLGTGTDRERPGSIMPVSAVSPGLGMGATLAETVAVRIYEDIVAQGRPVGSVLGSEAELMERYETSRAVLRAAVRLLEHHSVATSRRGPGGGLVVTRPEPRAAVDAAALYLAYRGVTAENLHVVREAIEVGTTARVAARREEPDIARRLKTLADRPPGQARGDGSAVQDFHAELAELAGNPVLSLFLRIITDLSRRTRAAHGRPDSAGMCLDDSDPAHGEILSAIRDGDAGLAQHRMRRHLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DT44</accession>
    <name>A0A1H6DT44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000021">
        <property type="protein sequence ID" value="SEG87886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG87886">
        <property type="protein sequence ID" value="SEG87886"/>
        <property type="gene ID" value="SAMN04489712_12126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG87886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="156" mass="17074" checksum="908A6507E1F75BB0" modified="2017-01-18" version="1">MTATDPAPTALAQGWCALSLLHGRIEAHIERALQAGHDLSVREYSLLDVLSRQHDGEGGHLQMKQVADAVVLSHSATTRLVTRLEERGLLQRYLCPTDRRGIYTDVTEAGRRLLEEARPTNDAALREALDEAAEHPELAPLVSAVKSFHVPAPTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DU31</accession>
    <name>A0A1H6DU31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aromatic ring-opening dioxygenase, catalytic subunit, LigB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000022">
        <property type="protein sequence ID" value="SEG88791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG88791">
        <property type="protein sequence ID" value="SEG88791"/>
        <property type="gene ID" value="SAMN04489712_12280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="105"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG88791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="378" mass="40786" checksum="D5A0F7916B99CC4B" modified="2017-01-18" version="1">MDAKVLENAILSLGRDTALLARFRADPAGVGAELGLDAEWAAVIADGRRDRLRSAGVVDGITILVSRWFADDLGDSTSSSRFHVEASAPLPDPDVPENLVFAGGCSHVPDLLARPEIDPADAVERLTDGYRRLAERLAAADPEVLLVTADCHFQSFRTGAFVIGTGASHTGSMEFFKRPDLDLTLTGDPEFAQAMVDAVRAEGMEVEESDRIDLDHGLIVPLRQLLPRPDLPVIPIITQPARSFSPFGARAFGQVLRTVVESRGRRVAMLATGGLSHWLDPGRFGGVDVEFDTYILEMLQAGRGNDLGNLEPYPLLDHGQYEFLNWLIMLGLAGPGVRGEVLAYEPMEASGGGWTVVDLPLPDRAPRDEGGRACLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DUT5</accession>
    <name>A0A1H6DUT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_12310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89051">
        <property type="protein sequence ID" value="SEG89051"/>
        <property type="gene ID" value="SAMN04489712_12310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG89051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="403" mass="47679" checksum="707D08EFA3A3B9A1" modified="2017-01-18" version="1">MTFNPLEHRGIPLDRQLRNWRELNVEPVDPDRADPYTKCRIITLNGIEIESIMFSHHFARVCPDLEIKQQLAEVRYIEQQQQKVVNWLLPGQSSVLETTISYEQVATDLTAWVARMEPDPYLRQAYEFGVLEDFDHLYRYANLYEMIEHRKAEKIVDNLTEVIPGRPTPLHHRDPVDNVREPYNRNEADPISKLHALTIMSAEQQTMNFYMNVGPLYMEPIARQLYQEIGLIEEEHVTHYESLVDPGETWWERLVNHEYNECYVYYSFMETESDPRVKAVWELHLNMELEHLRLACDMMRKHDGRDPESILARELPAPLTFEPNKEYLRNLLATQVDLTTLGTGYVREAHERFERMQERIHDAVTPPSDAVIDEHREMYGDEYRLQTEGEHPVKSLQHVRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DV50</accession>
    <name>A0A1H6DV50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH2:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000023">
        <property type="protein sequence ID" value="SEG89148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89148">
        <property type="protein sequence ID" value="SEG89148"/>
        <property type="gene ID" value="SAMN04489712_12331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="318" mass="33396" checksum="0A120769A2302F7A" modified="2017-01-18" version="1">MRAIQITEFGGPEVLTPAELPRPVAGPGEVLIEVSRAGINYADTHQAEDSYLSRSTLPMVPGGEVVGRTADGRRVVALTGSGGYAEWAVASAAMTWEVPDGVDDVTALGMVVQGASAWVLLRRSVHLAPGETVVVHAAAGGVGTLAVQLAKAWGAGRVIATASSKDKRELALELGADVAVDAGAEDMKSALIEANDGRRVDVVLEMTGGTVTDQSLRALAPFGRLAFYGMASRKPPAPVDPATLMAHSTTIAGMWLTHVFRLPGDVMRTALDELFALVAEGRLRVICGGEYALDEARKAHEDLRARRTTGKLVLDPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DXY6</accession>
    <name>A0A1H6DXY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000024">
        <property type="protein sequence ID" value="SEG89603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG89603">
        <property type="protein sequence ID" value="SEG89603"/>
        <property type="gene ID" value="SAMN04489712_1242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG89603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="56" mass="5526" checksum="4C600142FBC26B23" modified="2017-01-18" version="1">MPTPDPAGPPAAGTASADRPPVSPVAVRRWVCCHCGGTGLTGDGGTCPHCHGHGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DYT3</accession>
    <name>A0A1H6DYT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_12662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90520">
        <property type="protein sequence ID" value="SEG90520"/>
        <property type="gene ID" value="SAMN04489712_12662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEG90520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="15929" checksum="F54ADB422D0F200B" modified="2017-01-18" version="1">MRDLPGAIGLELGPSPWLTIDQARIDDFARATGDHQWIHVDVDRAARGPFGRTIAHGYLTLSMVPQLLSEILDVTNRGSGVNYGIDRVRFISPVVEGARIRMRGRLTEATPRGEGVRYRLELVIELEGSQRPAMVGEFIVLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZ98</accession>
    <name>A0A1H6DZ98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_1277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90680">
        <property type="protein sequence ID" value="SEG90680"/>
        <property type="gene ID" value="SAMN04489712_1277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7597" checksum="140A7BC01312E0DE" modified="2017-01-18" version="1">MAAFKKPFGFQPLEQQLAQRQAEQEARKPAQGKYFDHPTAKYVFIALTVVTVLAHVIALVVFGIMGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZB0</accession>
    <name>A0A1H6DZB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_12641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000026">
        <property type="protein sequence ID" value="SEG90449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90449">
        <property type="protein sequence ID" value="SEG90449"/>
        <property type="gene ID" value="SAMN04489712_12641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG90449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="308" mass="31601" checksum="5422A2AC2EAF9FA6" modified="2017-01-18" version="1">MSFVDFEGRSVVVTGAGGGLGREYALALARHGARVVVNDLGGTVDGAGGGAGMADGVVREIREAGGEAVACYDSVSTPEGGQAIIDAAMDAFGQVDAVIHNAGILRDRSLSNLSPEELDAVIDVHLKGGFNVTIPAFRVMKAASYGRIVLTSSSSGLLGNFGQANYGAAKTGLVGLMHVAAIEGARYGILANCIAPGARTRMTAGMLGELDELLDPAQVAAMAVYLASPQCTHTHEIYSAGGGRFARYVVGVNEGWFTPDGPASADDVLMHLDEIRDIGTLHVFDSGAEELALLRRMAAQAGALNPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6DZN3</accession>
    <name>A0A1H6DZN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterioferritin-associated ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_12742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000027">
        <property type="protein sequence ID" value="SEG90800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG90800">
        <property type="protein sequence ID" value="SEG90800"/>
        <property type="gene ID" value="SAMN04489712_12742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG90800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="144" mass="14823" checksum="A5349CE5D4FAB7E4" modified="2017-01-18" version="1">MYVCLCNGVTENDVHMSIAAGAGSTRDIRAACGMKPGCGVCTKRLFALLSEHRATNDPLKVTTGAAPAATPAVPRPSEPFSAEPFPSEPFPSEPFSAEPFPSEPFQPESFPSGPGRVPALPGAPGLPVALGLPRIPGARQETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E112</accession>
    <name>A0A1H6E112_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_12835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000028">
        <property type="protein sequence ID" value="SEG91101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91101">
        <property type="protein sequence ID" value="SEG91101"/>
        <property type="gene ID" value="SAMN04489712_12835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="94"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="226"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG91101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="456" mass="50806" checksum="C47DA38A87A90DDF" modified="2017-01-18" version="1">MTVTLLPVPDEPEEPEESAGRKSRKSRSRKRANGEGTIYQRKDGRYEGAAFVPTTAGTFKRVRLYGRTHDEVRRKLTKLLEQADQGIPVAAESWTVGQYLTYWLDNVVRPERKPRTAQGYESVIRLYLIPELGNKRLGKLAARDVRAFISRVRALCLCCKHGVDAAREVPRCCALKGGECCQSRLSVRMVQSIHAVLRNALETAVREEVIPRNVAKLVQVSAPKYKVNRGLTVDQARAVLQAAKDERLYALYVLALCLGLRRGELLGLRWQDIALMPCRACDGEGGEADGAECEVCAGNGIESATLEVVQTLQRVGGALRFVRPKTDDSERTIPLPALCITALCEHKIRQHAERADAWPDWQDHGLVFPSRLGTPMEPDNLRRSWGRIRETAGLEGVRFHDMRHTCVSLLLHLGVAPDVVREIVGHSDIEVTMTIYAHTSLDEKRAALRKLGDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E226</accession>
    <name>A0A1H6E226_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SAMN04489712_13030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91718">
        <property type="protein sequence ID" value="SEG91718"/>
        <property type="gene ID" value="SAMN04489712_13030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SEG91718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="1176" mass="129110" checksum="23E70A260E7C1DDB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E2X4</accession>
    <name>A0A1H6E2X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type sugar transport system, substrate-binding protein, contains N-terminal xre family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91887">
        <property type="protein sequence ID" value="SEG91887"/>
        <property type="gene ID" value="SAMN04489712_13115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296482" evidence="1">
        <location>
            <begin position="30"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="89"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG91887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="375" mass="38555" checksum="5ACCB4E9583E5131" modified="2017-01-18" version="1">MTRGRLRAGATLVAAMVLLTACGGGEGSAPSGATGPAAATNQEAAAEVKALLAGDVEFPMPTEPVNPGAHRVAVIASGLASPGPSVLAENSMEAIKAIGWTADPPGDGKFTPTTQAQLIEKAVLDKVDGIILVSITPSAVAAAVKAADDAGIPVVCALCGPDLPEGMVGVGNDHKAAGRAQAAYAASLAKPGDTIVVYQNTEFKQSEEQMAEAAAAVKEMCPDCKVKTPSLLLAEAMQPNAPIFTSLLNDYRKGSLSSVVMPFDSPASVLANSAAQLGRDDFAVIGLGALSPFVDMVGTGRPAVAKADVLISTPLYGWASVDELARMLAGAKTWAADRMPVALVDQETYGNYEKGKLFVLPKFDYKAKFTELWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E3K2</accession>
    <name>A0A1H6E3K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_1307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000030">
        <property type="protein sequence ID" value="SEG91644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91644">
        <property type="protein sequence ID" value="SEG91644"/>
        <property type="gene ID" value="SAMN04489712_1307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="236" mass="25094" checksum="36B4FFB62F37E184" modified="2017-01-18" version="1">MTETTDALEIRGLSAGYRGVPAIRDIDLRVAAGSILALLGPNGAGKSTTLRAAAGLLPALGGTVTAAGSPVTGSVERATRSGLCLIPDNRGVFHRLTVAENLRLAKARGGFGPALDRFPQLRPLLNRRCGLLSGGEQQLLAIAKTLLLRPRVLLIDEMSMGLSPVAIKQILPELRRLADEDGTAIVLVEQHIDQALSVADEAVVLHHGRVVLIGPAADLREDRDQIQRAYFGDKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E4G6</accession>
    <name>A0A1H6E4G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_13118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000031">
        <property type="protein sequence ID" value="SEG91894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG91894">
        <property type="protein sequence ID" value="SEG91894"/>
        <property type="gene ID" value="SAMN04489712_13118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="229"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG91894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="370" mass="38409" checksum="7C3FE6BB6BF1F4C7" modified="2017-01-18" version="1">MISAEELRALRDATRRLVRAWTPQSADDHEAAASAPPDRRTWAGMARRLGLQGVRVPEELGGTGLELEAELVVHEEMGGALHGGPFLPVVGQAVPALLTLAGDERARTMLAEIAAGTSVVVPADARWYEPDAALPVLSDGADGPTVSGVVPGVMAGAAADGWLVPADAGGRTALAWVPAGTAGAATEPMTTIDLTRGFATLRLQDAAAVVLARDGEAERARDAMETGAALALAAECVGIAAEALDLTVAYVKVREQFGQVIGAFQGVKHQLADLYVTLESARSALAFAARSVGESPPLRDAALAVARRRCGAAAFKIANEAIHLHGGIGFTWEHRVHLYYRRAKTNQVLLDTGGGQARTIAANVAALYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E624</accession>
    <name>A0A1H6E624_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_13349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000033">
        <property type="protein sequence ID" value="SEG92416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92416">
        <property type="protein sequence ID" value="SEG92416"/>
        <property type="gene ID" value="SAMN04489712_13349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG92416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="150" mass="15697" checksum="15B2B655FE8C585F" modified="2017-01-18" version="1">MSGYGDQSSGGWSDPYSYQSGGHDPAGQQGWDPYGQYAQHQQPTGQMYGYGYGPPGVPQGRVDNSSAIVALVCNSVATLICCNLLCIGGIVTSAIALGRAQTDPHESRSLVKWSWVILGVSLVLQILLIAVLMMAGAFSEDGSGYDSGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E765</accession>
    <name>A0A1H6E765_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_13515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000035">
        <property type="protein sequence ID" value="SEG92735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG92735">
        <property type="protein sequence ID" value="SEG92735"/>
        <property type="gene ID" value="SAMN04489712_13515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009296613" evidence="1">
        <location>
            <begin position="32"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG92735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="963" mass="104044" checksum="CB838D44CC5E9FBB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7C7</accession>
    <name>A0A1H6E7C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_14023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93728">
        <property type="protein sequence ID" value="SEG93728"/>
        <property type="gene ID" value="SAMN04489712_14023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="183"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG93728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="328" mass="33866" checksum="4C23E57FDB7C53F6" modified="2017-01-18" version="1">MRFALSNEQRGFAQALDDLLGDAQVPAVSRSWADGDAATGLELWKRLADLGVTALCVPESHGGLAAEPADMVVAFEALGRHLAPGPYIESAVLAPALLTAAGGGPSLDEVASGSAIVTAAAPPMTPFALDADVADHVLLVDGTTLRAAQAGEPRTSVDRSRRLFEARPGEPLGSVDPVQVGRAFDAATLACSAQLLGAGEHVLATSVEYARSRWQFGRAIGEYQAVKHALADVRVALDFARPLVYGAAVALGDDGADASRDVSAAKAAASAAAYRASRTALQTHGAIGYTEEYDLGLWITKIRALTTAWGTVGFHRARVLDAVTAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E7Z3</accession>
    <name>A0A1H6E7Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000037">
        <property type="protein sequence ID" value="SEG93076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93076">
        <property type="protein sequence ID" value="SEG93076"/>
        <property type="gene ID" value="SAMN04489712_1375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG93076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="32639" checksum="C8CAC8DD812FE714" modified="2017-01-18" version="1">MTPETPGAGSTVRRILLGSQLRRLRERKGVSRQEAGYVIRASESKISRLELGRVSFKERDVADLLTLYDVTDEAEREALLQLARDAKTPGWWHRYNEVLPKWFQAYVGLEEAAALIRTYECQFVPGLLQSEEYARAVIRLGNAGATEDEIEDRVTVRMQRAQRLTAPHAPRLWAVLDEAALKRQIGGPEVMRSQFEHLIAMSKLPNVTIQVMPFRFGGHAAEGGAFSILRFPEPDLPDVVYVENLVGALYLDKRDDVDNYLQAMERLCVDSETPERTVEMLGDLLRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9G6</accession>
    <name>A0A1H6E9G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_14617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000046">
        <property type="protein sequence ID" value="SEG94332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94332">
        <property type="protein sequence ID" value="SEG94332"/>
        <property type="gene ID" value="SAMN04489712_14617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="87" mass="10043" checksum="6A1FF0D8F4DEECD0" modified="2017-01-18" version="1">MDRFLPGLSEEEVDRWVPSACVLWMRMLDRLHGPHRPRLVVIDPRVTPVAREADVHLAARPGANVNQPRHPTGHRSWLDRQHHCAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6E9H7</accession>
    <name>A0A1H6E9H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase/fumarate reductase, flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_14033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000040">
        <property type="protein sequence ID" value="SEG93769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93769">
        <property type="protein sequence ID" value="SEG93769"/>
        <property type="gene ID" value="SAMN04489712_14033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="13"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEG93769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="515" mass="54331" checksum="620DC62D41553004" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EA99</accession>
    <name>A0A1H6EA99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000041">
        <property type="protein sequence ID" value="SEG93854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG93854">
        <property type="protein sequence ID" value="SEG93854"/>
        <property type="gene ID" value="SAMN04489712_1419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG93854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="259" mass="28663" checksum="367B2056318BA8BA" modified="2017-01-18" version="1">MPFLGERFLARALREGGRRRSTAGADGMTWAAYRRQAHVLIPRLAQALHEGTWRPGPLRRTSFATYTGKELPCAIPTVQDRIVHRAMRAAVEPILEARAFADWVSGYRPRRNRITAMRQAMAHTDAGCRWVADVDVKQVSAGSNAAEVTDWLARYVHDGTFLDRFRTAVAGLPSPLAPGSGLTPILINLRLTPADRLLADLRIVRFADNYCAFASERGEAERAFHRITETLAAIGLSANRTKSRVRAEACVEDLFLIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6EBP5</accession>
    <name>A0A1H6EBP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_1731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000073">
        <property type="protein sequence ID" value="SEG95187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG95187">
        <property type="protein sequence ID" value="SEG95187"/>
        <property type="gene ID" value="SAMN04489712_1731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG95187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="120" mass="12951" checksum="E668EB570B18A2E2" modified="2017-01-18" version="1">MQAFQTGEIPHGFAINENGGLIHYKYAIVLAVPMANQSGWSGDGFLSFGSDWADVRLRVAIHNGSTWSVIKTYDVTAGGLRVGDQLPASSQKVSIGRVKKGPNDTVDNAPVSWLLQYQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6ECI8</accession>
    <name>A0A1H6ECI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000057">
        <property type="protein sequence ID" value="SEG94983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG94983">
        <property type="protein sequence ID" value="SEG94983"/>
        <property type="gene ID" value="SAMN04489712_1574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG94983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="288" mass="31635" checksum="F948E9A8B177E0D2" modified="2017-01-18" version="1" fragment="single">MTITTTFKATVATARDRWTARRRYFGTEEVFNETWQSLYSIEHPIPRGVTLGKLADICDALHDQHVAAFGDTLRAETLAANEQLLSMAASCELQLARSTWKPVDELRAGDSFEFAGEWAKVLDVTQTQPAVFQVRFAMADIGEDDGGIKTLEWDAGETVRTSGADRPDLEVTGLACGYGITGQELTEWQRLATTADRDHRAGIYATLADLAEQRLGTGAAETLRELAATEVELIRPVPLPKPICPREVRAFFAVVLAVFGAQVAVLAQTPVLTWPWFVQFGTYALVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5S0U8</accession>
    <name>A0A1H5S0U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF44209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF44209">
        <property type="protein sequence ID" value="SEF44209"/>
        <property type="gene ID" value="SAMN04489712_10134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045436">
        <property type="entry name" value="DUF6507"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20117">
        <property type="entry name" value="DUF6507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF44209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="115" mass="11607" checksum="7F3A13E0C6B2A56D" modified="2017-01-18" version="1">MTGWNIAPGEVANVVTTVGGYIGDADGGDGLVGQIEDFARHVEDAAMAASSMPIGTALKEYVTHTSPGLKGMVTKTASCVTGAVQATKAYINGDLEMAAEAQRNAVDAPAPRIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5SLS8</accession>
    <name>A0A1H5SLS8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="7" type="ORF">SAMN04489712_101269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF51536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF51536">
        <property type="protein sequence ID" value="SEF51536"/>
        <property type="gene ID" value="SAMN04489712_101269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEF51536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="177" mass="20021" checksum="2CBFA1D84A7028EE" modified="2017-01-18" version="1">MASAMRKMAVYLGLVEDDRYDDKYDDYDEYDVYDDETADHGRRRSEESGGQLTRAEDGPDRDRDHHAPSPPDRRSVALYESGSSDLARITTLHPRTYNEARIIGEHFREGTPVIMNLTEMSDSDAKRLVDFAAGLIFGLHGSIDRVTNKVFLLTPANVEVTAEDKARMAERGFFNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T135</accession>
    <name>A0A1H5T135_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_101440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF56486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF56486">
        <property type="protein sequence ID" value="SEF56486"/>
        <property type="gene ID" value="SAMN04489712_101440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="281"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF56486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="376" mass="39477" checksum="67F1B4530C9A1667" modified="2017-01-18" version="1">MTSDGTTRLRLPRGRAADAALAIAAFLLSITGTVQAFVGGPDEPWATTVLGWLLIAVACAALYVRRRHPVAVAALVFAATCAYYLTSIYDGPLLATLVVALYTVAAQGRLQAAVALSSLTVISVGAGTLAGNREIDGLALFLLTGWLVAVVALGWVAHSRRVYFREVRQRAASEERLRIARELHDVVGHHMSLINVQAAAALHRIGRDPAQAETALGAIKESSREALRELRATLGVLRQADEDAPTAPAPGLDRLAELVRSAEQTGLRVRVDGAPGPLPTEVDLAAYRIVQESLTNVARHAHARTVTVRLGDGPGEVTVEVEDDGHGPVPGSSGTGIGGMRERARALGGELTAGPRPGGGFAVRARLPRRNGASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5T7V3</accession>
    <name>A0A1H5T7V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF58895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF58895">
        <property type="protein sequence ID" value="SEF58895"/>
        <property type="gene ID" value="SAMN04489712_101517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF58895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="271" mass="29655" checksum="49BBD842F8B879C8" modified="2017-01-18" version="1">MGAEPMGLKGDDLGTPYLRFERRGPLAWCVVDRPGSRNALTSAMYFGVRRAVDLVNRDPELAALIITGTGDVFIPGGELRGDEPDRWLDFPDLLGLDSTPFEAIRRSPKPVVSAVNGIAQGGGLLIAMLSDVAVAGESVTVRAPELLRGIADTGYAAYLPAQIGIARARDMLLTGRVVTAREAESWGMFSRVVPDERVLAEAEEVAIQICRTAPQARLHLKRIINDNYGRVDRTTFDALLFNEEMREGGRAFAERRDPSWVPPHFRTGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TFN7</accession>
    <name>A0A1H5TFN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF61626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF61626">
        <property type="protein sequence ID" value="SEF61626"/>
        <property type="gene ID" value="SAMN04489712_101601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024029">
        <property type="entry name" value="Pyridox_Oxase_FMN-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04025">
        <property type="entry name" value="PPOX_FMN_DR2398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF61626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="212" mass="23679" checksum="2D8D711E02390E32" modified="2017-01-18" version="1">MASDTGFVEVASEARLRELLGTPMPRAVAKERARLHEMDRRWLAASPFCLIATADAEGNCDVSPKGDPPGFVHVLDETTIAVPDRPGNRRVDGFRNILANPRVGLIFLVPGRGETLRINGRARLLSDAPFFDAMVVKGHRPRLALVVEIEQIFFHCAKAFLRSDLWRPETWDPGALPSHAAITKSVMNTEETLEELERYYGAEYAKSLYVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TJL8</accession>
    <name>A0A1H5TJL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted arabinose efflux permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_101620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF62207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF62207">
        <property type="protein sequence ID" value="SEF62207"/>
        <property type="gene ID" value="SAMN04489712_101620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="32"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF62207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="493" mass="51072" checksum="86ADFA74E47E4FC5" modified="2017-01-18" version="1">MTATVTRKPRENHPAPDRPEERQRWPARLWGVLIVLSLVLFLDGLDVSMVGVALPSIGAELGLGTSSLQWIVSGYVLGYGGFLLLGGRTADLLGRRRVFLAALAVFALASLLGGLVDSGPLLIATRFVKGVSAAFTAPTGLSIITTTFAEGRARNRALSIYTVFGASGYSSGLIFGGLMTGLGWRWTFLMPVPIAAAALVAAHLLIPRDRPAAGGGHDPLGALTSTGAMLLLVYNLVSAPERGWTAPVTLALFAAVAALLAAFVAVERRLAHPLVRLGILRKGTLVRANAAIVALFGSYLSFQFIVTLYLQDVLGWEPLTMALALLPAGLLVALSAPYAGSMIDRFGTARFIIGGMAALTAGYVLFLPIGTDPVYLTAVLPSVVLLGVGFALGFPAINVQATSGIHDDEQGLAAGLVQTSGQVGAALVLAVTTALITADGTGDGSAQAMLDAFRPGLVFVTFVALAGLAIVLVPLLRRRSAETVPVTAAAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TLL7</accession>
    <name>A0A1H5TLL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF63666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF63666">
        <property type="protein sequence ID" value="SEF63666"/>
        <property type="gene ID" value="SAMN04489712_101669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF63666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="52" mass="5749" checksum="9671C309A2346A80" modified="2017-01-18" version="1">MITGGRSRPGRGHGVRPKCQIDNRPNGLYRGDVNHSKLVNVLQRQIHTPACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TMN1</accession>
    <name>A0A1H5TMN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_101681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF64033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF64033">
        <property type="protein sequence ID" value="SEF64033"/>
        <property type="gene ID" value="SAMN04489712_101681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF64033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="158" mass="17277" checksum="E5FD40EA5A755C66" modified="2017-01-18" version="1">MGSSGGEPGSESTPAGPAAVKAPPSLLYMVKRLELAARSRLEGLVRPAGVTALQYTALTVLERHDGLSAAQLARDSFVTAQSMADMVRALENRGLIRRERNPANRRELLIHLTDTGRALLADLAEPVRRLEEHMTGDLTSQQVAQFRHALSRTWRTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TRP3</accession>
    <name>A0A1H5TRP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase, activator-dependent family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_101722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF65475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF65475">
        <property type="protein sequence ID" value="SEF65475"/>
        <property type="gene ID" value="SAMN04489712_101722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="DUF1205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030953">
        <property type="entry name" value="Glycosyl_450act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="DUF1205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04516">
        <property type="entry name" value="glycosyl_450act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1205" evidence="4">
        <location>
            <begin position="223"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF65475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="437" mass="48120" checksum="39DA975A93A5ACC3" modified="2017-01-18" version="1">MRVLFVTLPVKAHLYVQVSLAWALRAAGHEVCVAGQSQVVDDITHTGLTAVPIGAPLDHEAAMAEVRQRQEESQEAEERGEEAHPWETEWEKVLDITESRPEKLTHDYLHGVNTVWTFNIQTLSPPDMTDDLVTFARTWRPDLVIWDALIYAGPVAAKACGAAHARMLFSLDLLGRMRQRYKGELARRPVEVWDDPMEEWLGATLDRYGCGYSDDLMSGQWTIDPVLPSMRLPVDLPYVPVRFVPYNGRAEVPGWLSEPAESRRLCLTLGLSLRSMGGDRVSVAELLDAVADLDVEVVATLNAEQLAGVDKVPDNVRAVDFVPLNELLPGCSAIVHQGGFGQTQTAMAHGVPQVVLPNGYWDTVLRAGQVQDFGAGLAVGDPDRVSAAEIREKVVRVLQEPGFAVSAARLREEMLATPAPAEIVPLLERLTAEHRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5TZR6</accession>
    <name>A0A1H5TZR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_101812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68315">
        <property type="protein sequence ID" value="SEF68315"/>
        <property type="gene ID" value="SAMN04489712_101812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF68315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="179" mass="19913" checksum="D7D7D89E9F3AB700" modified="2017-01-18" version="1">MTVHEAGIGRYFEDYTVGDVYQHPFGRTITEADNTWFTLLTLNTNQNHFNADFAARAPYGKVIVNSGLTVALVLGLSVVDMSQNALLNLGWTDIKLTHPLFVGDTVYAESIVTETRESKSRPYAGIITMRTRGLNQDGEEIVSWVRSVMIYKRGATHDKNYFPEAKTGRLRLPSAGDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5U1W9</accession>
    <name>A0A1H5U1W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_101810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000001">
        <property type="protein sequence ID" value="SEF68257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF68257">
        <property type="protein sequence ID" value="SEF68257"/>
        <property type="gene ID" value="SAMN04489712_101810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="1">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF68257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="166" mass="18115" checksum="66FAC25F5BC9608E" modified="2017-01-18" version="1">MTLLTDEIRALVGLKRIYTAPEELGAAAGRYFGLAVGDHNPLYSDSEYARAQGLEGVTAPLTLICETNQYADLPIPPDGYAGHEWGIELPGTRKVRGGNSYTFHRRVRPDDVITATWEITDVTEKTTRSGAEMLIIASRATYTDQQGGLLAENEETIIFVALEAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5V633</accession>
    <name>A0A1H5V633_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Malate dehydrogenase (Oxaloacetate-decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SAMN04489712_102183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF82789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF82789">
        <property type="protein sequence ID" value="SEF82789"/>
        <property type="gene ID" value="SAMN04489712_102183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="5">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="4">
        <location>
            <begin position="172"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SEF82789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="399" mass="41863" checksum="AC58FFCA6A838F3B" modified="2017-01-18" version="1">MTGVAVAAESDSTYDYDNDPAFILHQGGKLEVRSTVPVRDADDLSLAYTPGVARVCTAIADHPELAYDYTWTSKVVAVVTDGTAVLGLGDIGPAASMPVMEGKALLFKQFADVDSVPIALNCTDTEEIIETVIRLAPSFGGINLEDISAPRCFEIEDRLRAALDIPVFHDDQHGTAIVALAALRNAARLVGKPLSRLRAVVAGAGASGVAVTRILLNAGIGDIAVSDSKGLIYQGRDGLNPIKQALARDTNSAGLKGSTEEALNGADVFIGLSGSTVREECIATMSDDAIVFALSNPTPEVHPEAARRHARVVATGRSDFPNQINNVLAFPGIFRGALDVRAHTITEGMKLAAAEALAAVVGDELSADYVIPSPFDERVAPAVTTAVAEQARREGVNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VAK6</accession>
    <name>A0A1H5VAK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-2-hydroxyglutarate oxidase LhgO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF83848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF83848">
        <property type="protein sequence ID" value="SEF83848"/>
        <property type="gene ID" value="SAMN04489712_102221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF83848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="391" mass="42104" checksum="789CA73C7450C2A0" modified="2017-01-18" version="1">MTHIGVVGAGILGLATARRLAAAGAEVTVLDKEGRVAAHQTGHNSGVAHAGLYYAPGSLKATLCRRGIGMLKEYCAERGLPYVECGKVVVARDQGEVPRLREIERRATENGVPGLRWLDAAGLHEVEPHASGVAALRSPYTAIVDFPAVTRAFAEDVTKAGGTVRLGFEVTRIRAMGGEVVVNEELVFDRLVVCAGLQSDRVARLAGDSPAPAIVPFRGEYYRLVPSRTDLVRGLIYPVPDPRYPFLGVHFTRRVDGGVDVGPNAVPALAREGYRRRDLRPADLWETLRWPGFRRLARRHWRTGLREMYGSAFKHAFAAEARSFVPELAAADLVPAPAGVRAQAVDPDGSLVDDFRIGRRGPVVTVRNAPSPAATSSLAIAEHVAAQVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VCY4</accession>
    <name>A0A1H5VCY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biotin carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84698">
        <property type="protein sequence ID" value="SEF84698"/>
        <property type="gene ID" value="SAMN04489712_102253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="111"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF84698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="387" mass="41437" checksum="66B9A540BBAF2711" modified="2017-01-18" version="1">MDARLPLVLLAGKATDSVTHGFLPAAARLGLRVTVLTDRPGDHLGRYAGVAVTGCEVTDYRAVVDAVCRLGEPPAAIFSNSDFLQAPAALAAAYFGLPGKDWRAATRTKNKALLRWHLASIDPVFSAQVTEDGVPEGPYPLVLKPREGVASEDVFLVDGPEELAARYAEIRERRADPLVAEEYLPGRLHTLETLGDGERLHVLGSFRTTVSPPRFVEERLDWAPPPPESGQVLAQLAALGVGFGACHTEFVVHAGRARIIEVNYRIIGDHGDFLLADLLGVPVFEQVLRVHLGEPLGPPPPPAAGHAVIDSVIADRAGVLRAAPEFTERTDGGVRLTYRPVRRAGDTVTLTGTNRDYLGTVQAIGPDAATVDAALARFRAACTWEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VDB6</accession>
    <name>A0A1H5VDB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">whiB</name>
        <name evidence="14" type="ORF">SAMN04489712_102244</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF84457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF84457">
        <property type="protein sequence ID" value="SEF84457"/>
        <property type="gene ID" value="SAMN04489712_102244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SEF84457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="89" mass="9780" checksum="8B3EE5D56E521F80" modified="2017-01-18" version="1">MQGALAMSDEDLTLPCRTDPELFFAEAPADVELAKALCLDCPIRKECLAGALERQEPWGVWGGELFVKGEIVARKRPRGRPRKNAEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VEZ2</accession>
    <name>A0A1H5VEZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A-factor biosynthesis hotdog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF85935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF85935">
        <property type="protein sequence ID" value="SEF85935"/>
        <property type="gene ID" value="SAMN04489712_102299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005509">
        <property type="entry name" value="AfsA_hotdog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03756">
        <property type="entry name" value="AfsA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AfsA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AfsA" evidence="2">
        <location>
            <begin position="209"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF85935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="351" mass="37341" checksum="502A08D5A24F51DE" modified="2017-01-18" version="1">MAAGQEVAAPPADFGYTRTVDRTLVHRAAVSEVFVTDIRTVAELDEAGLSGGRAWVAAQLPLSHAYYSDHIQEPALFDPLLLLEACRQAAICGTHAHAGIPVGTSIVVGTFTLELDDLPGLAVGERPGELAVDTEFVGKPTRRGRLRNVGVEQRLYLGGAPVGRHSMQVMMLTARQYEVLREAGRDTPAPWTTDYVGKPRTGLVEPRRVGRVHPGNVVLADPVREGGAVSARLAPDFANRGLFDHDYDHLPAMILAEAARQLALLALDGGGTGRQVAALTARFGRFAELDAPLTATAVVDPPDGPAGPSEPSGPDGGRVRLRVDFTQNSTEVAAFSLTLADLSRAAERNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VG30</accession>
    <name>A0A1H5VG30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SAMN04489712_102307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF86160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF86160">
        <property type="protein sequence ID" value="SEF86160"/>
        <property type="gene ID" value="SAMN04489712_102307"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SEF86160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="246" mass="26327" checksum="B9594861BF1C0122" modified="2017-01-18" version="1">MSENKIVIVTGGSRGIGRAVALHMAREGYDVAFCYRSASPAAEKTAEDVRGYGVRCHHAPCDVADAAAVEAFTESVSERLGKPDVLVNSAGILRDNALVLMTRDDWDAVIDTNLSGTFNFCRAVVFDFMKRRSGVIVNLSSVTGIYGNPGQVNYSAAKAGINGMSRALAKEVARHGIRVNVVAPGFIETDMTNELPEKLRKAALQKVGMRRFGRAEDVAETVAFLASDKASYITGQVIQVDGGIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VQB2</accession>
    <name>A0A1H5VQB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SAMN04489712_102406</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 43163</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF89196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF89196">
        <property type="protein sequence ID" value="SEF89196"/>
        <property type="gene ID" value="SAMN04489712_102406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="188"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SEF89196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="457" mass="48254" checksum="0CB04B3DE5E1C4C8" modified="2017-01-18" version="1">MAISVFDLFKIGIGPSSSHTGGPMAAAHRFARGLHRDGLLDKTGSVRAVLYGSLGLTGKGHGSDKAVILGLEGDKPELVDVDTVPDRLAAVRERGVLRLFGRVEVPFTVGEHLVFERRESLPGHPNGMRFTAFDANGEELRSRVYYSVGGGFVVDESATGADRIKADDTVLPYPFDSGAELLARCAETGLSISALMLENEKAFGRSEAEINAGLVELWQVMRACVRRGCTTEGLLPGGLKVRRRAPRLHRRLVGEPPSDPLHAMDWVTLFALAVNEENAAGGRIVTAPTNGAAGIIPAVLHYYERFVPGADDSGAVRFLLTAGAIGVLFKQNASISGAEVGCQGEVGSACSMAAAGLAEVLGGTPEQVENAAEIGIEHNLGLTCDPVGGLVQVPCIERNAVGAVKAITAARIALRGDGHHFVSLDKAIKTMRDTGRDMLDKYKETSRGGLAVNVIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VRV5</accession>
    <name>A0A1H5VRV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease BN, tRNA processing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_102435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF90039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF90039">
        <property type="protein sequence ID" value="SEF90039"/>
        <property type="gene ID" value="SAMN04489712_102435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEF90039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="249" mass="26755" checksum="B3F4D28FB3C684FD" modified="2017-01-18" version="1">MRVTVIGCSGSFPGPESPASSYLVEADGFSLLLDLGNGALGSLQRFHDVLDIDAICFSHLHPDHCLDLTVYWIARVYCPFGRAPLIPVYGPTGTADHMAKAYEPEPNPDMGVAFEFHGFPAGPFDLGPFRVTAALMNHPVEAYGLRIEHGGSVLAYSGDTGRCDALVDLARDADLFICEAAFVEGRNNPPDMHLTGREAGDHAARAGVDRLVLTHLLPWNDPAVTLAEAKMSDYAGMIELAQVGTVYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VX02</accession>
    <name>A0A1H5VX02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_102484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF91401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF91401">
        <property type="protein sequence ID" value="SEF91401"/>
        <property type="gene ID" value="SAMN04489712_102484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEF91401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="281" mass="30733" checksum="8B586485E73E4CE1" modified="2017-01-18" version="1">MSSAVRVSGLAKRYGEVRAVDGIDLEIERGEVFALLGPNGAGKSTTVEILEGHRRRDAGRVEVLGHDPGRATRQWRARLGIVAQTTREAPELTVREMVRHFAGYYPRPRDPDEVIEAVGLTDKTRTRLAGLSGGQRRRVDVALGIVGDPELLFLDEPTTGFDPEARRAFWELIRGLAHDGTTIVLTTHYMEEAEVLADRVAVIAGGRILAVDTPRELGGRATEVAEVSWLEPAEGRRTLRAASPTQVVAELAERFGGEVPGLTVARPTLEDVYLRMIGETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VXK2</accession>
    <name>A0A1H5VXK2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="8" type="ORF">SAMN04489712_102508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92009">
        <property type="protein sequence ID" value="SEF92009"/>
        <property type="gene ID" value="SAMN04489712_102508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="7">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF92009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="356" mass="39358" checksum="D8D0D2A0FFC73180" modified="2017-01-18" version="1">MNLDELIGEYADIEGRLADPAVHADQNTARRLGKRYAQLRPIVETVRQVRTVTDDLATARELATEDATFAAEATELEGRRAELEERLRKLLVPRDPNDDKDVILEIKAGEGGEESALFAGDLLRMYLRYAERIGWKTEIIASQPSDLGGYKDVTVAVKARPGADDEGGAWARLKFEGGVHRVQRVPVTESQGRIHTSAAGVLVTPEAEEVDVQIDPNDLRIDVYRSSGPGGQSVNTTDSAVRITHLPTGVVVSCQNEKSQLQNKEQALRILRSRLLAMAQEEADAAAAAERKSQVRTVDRSERVRTYNFPENRISDHRVGYKAYNLDQVLDGDLHNVIQALVDADTERRLAEAQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5VZ38</accession>
    <name>A0A1H5VZ38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_102528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF92542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF92542">
        <property type="protein sequence ID" value="SEF92542"/>
        <property type="gene ID" value="SAMN04489712_102528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEF92542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="141" mass="15246" checksum="797182F5ED147152" modified="2017-01-18" version="1">MGRASAARDVRRLLEAGLRIPYAGPEGIGRTEQALWEVERLAARLSRRHGRLRFLGMLAVTVQRGVGELARLTGRSPEDIAAEHTGFCPDRGLREWMAEVMSAPAGAAWSPPPADAPIDPAMALVHLHVTVCLALCCATDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W2V7</accession>
    <name>A0A1H5W2V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phage shock protein PspC (Stress-responsive transcriptional regulator)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_102559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF93481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF93481">
        <property type="protein sequence ID" value="SEF93481"/>
        <property type="gene ID" value="SAMN04489712_102559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEF93481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="68" mass="7624" checksum="4B1AAB1A8B904AE0" modified="2017-01-18" version="1">MTGLYRPRQGRVIAGVCAALARRSGLTPWTVRALALLSCLLPGPQFVVYLVLWVMLPNEEKYLVHSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5W874</accession>
    <name>A0A1H5W874_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SAMN04489712_102624</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF95600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF95600">
        <property type="protein sequence ID" value="SEF95600"/>
        <property type="gene ID" value="SAMN04489712_102624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="21" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="20">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="18">
        <location>
            <begin position="178"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="19">
        <location>
            <begin position="276"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="464"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="SEF95600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="587" mass="58946" checksum="A7BEDDE24C2D6A43" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5WA98</accession>
    <name>A0A1H5WA98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_102645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000002">
        <property type="protein sequence ID" value="SEF96402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEF96402">
        <property type="protein sequence ID" value="SEF96402"/>
        <property type="gene ID" value="SAMN04489712_102645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="2">
        <location>
            <begin position="127"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEF96402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="217" mass="24068" checksum="CD40A76AF181DAB8" modified="2017-01-18" version="1">MRIDPIGRDEARELARRELEKGIYRRDEPSWLERAWNNFNDWLNELFNRAAEPTAPGNGGGWLSLLIILVLLAATVALVGWLMRGRFNVRSARESLLADQPSTAKDHRSAAERLAEAGQWAEAIRERLRAIARDLEERVILDPRPGRTADELAAEAGAALPDHAEGLRTGVRIFDDVWYGDRPGTREGYAALVALDERLRAAKPKAIESGEPAGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X117</accession>
    <name>A0A1H5X117_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tight adherence protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SAMN04489712_10345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG05471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG05471">
        <property type="protein sequence ID" value="SEG05471"/>
        <property type="gene ID" value="SAMN04489712_10345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="168"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SEG05471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="307" mass="32422" checksum="5169882F55D279F1" modified="2017-01-18" version="1">MTGVLTLLAGMAAIAGGLILLLAPPRRADRPTGVAGALHSIETEYAGRAGGGTTPASRDERLAEPLMRRLRMLAKSLSPGTGPERLQHRLDIAGNPGTWTPERILAYKGLGLFLLGATGALIASGSVVGLLLGAAVGAAAGFFLPDILLYNAGLRRQAELHRALPDILDLLVVSVEAGLGFDAALTRVAQNTDGPLADELARVLQEIRIGKSRQDALRAMGERVSVEEVRAFIAALVQAGELGMPIGQVLREQAREARIKRRQQAEEAAQKVPVKIIFPVVMCILPALLIVVVGPGILSIMESPLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X5F5</accession>
    <name>A0A1H5X5F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG06988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG06988">
        <property type="protein sequence ID" value="SEG06988"/>
        <property type="gene ID" value="SAMN04489712_10396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG06988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="343" mass="35820" checksum="D3450DCFE64B631A" modified="2017-01-18" version="1">MRVFVTGASGFVGSYAVAALLAAGHTPRALVRDPARAARVLAALGVDTGRVDMVTGDMLDEAAVGEALDGCQAAIHAAASVGVTGAGGDLVEINVGGTRNVVGGAVRRGLDPVVHVSTVAVFVPPRDPVITVDGPLASPRTGYGRSKVAAERYVRGLQDEGAPVTIVYPGGVCGPCQPVLDSLMEGLVGALGKMWPLPPGGVSVIDVRDLGEALARAVVPGQGPRRWLLGGHYLTWREYADLCDALTGVKCRRLRVPGTALLAMGALLDAAKRVRDFRYPLTRDAAEFMTRLVPTDDRPALEALGLGLRPIEETLSDGLRWLAEAGHLDPRKAGRLAPVAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5X5H6</accession>
    <name>A0A1H5X5H6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="13" type="ORF">SAMN04489712_10397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG07014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG07014">
        <property type="protein sequence ID" value="SEG07014"/>
        <property type="gene ID" value="SAMN04489712_10397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="606"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="696"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="364"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG07014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="798" mass="85728" checksum="2AAB8487D1623336" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XKI6</accession>
    <name>A0A1H5XKI6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coproporphyrin III ferrochelatase</fullName>
            <ecNumber evidence="7">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cpfC</name>
        <name evidence="9" type="ORF">SAMN04489712_103296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="7"/>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12271">
        <property type="protein sequence ID" value="SEG12271"/>
        <property type="gene ID" value="SAMN04489712_103296"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SEG12271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="335" mass="36469" checksum="E49C2DDE2F6D2C1E" modified="2017-01-18" version="1">MTSYDALLLVSFGGPEGPQEVIPFLENVTRGRNIPRQRLEQVAEHYYLFGGVSPINRHCRELKAAIEADLAAHGIDLPVYWGNRNWTPYLADTVRQMAADGVRRAAAFVTSAYSGYSSRGQYADDIARARAEVPGAPEIDKLRTYYNHPGFVEPFVEATHAALDRLPAELRDGAHVAFTAHSVPLDQPGRERYAAELADIAAVVAERAAPGHDRALVYQSRSGPPTQPWLEPDIGDHLRKLHAAGTRAVVVVPIGFVSDHMEVKYDLDVEAAELAAELGLAFERAATPGTHPRYVAMVRELLLERTAGPDAPRPALGTLGPHPDDCTAGCCRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5XKR3</accession>
    <name>A0A1H5XKR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_103299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG12344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG12344">
        <property type="protein sequence ID" value="SEG12344"/>
        <property type="gene ID" value="SAMN04489712_103299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG12344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="505" mass="53733" checksum="F08D4E5EB69CDC06" modified="2017-01-18" version="1">MQELRLVAVSEDGTYLVLATAGRGTRFTLPVDDRLRAAVRGHFSRLGQFEIEVESPLRPKEIQARIRAGETAEEIAESAGIPVERVRWFEGPVLQEREYMAQQAQRVPVRRPGESAPGPPLGEQVEERLNRGGVDLEDVEWDSWKCEDSSWRIRLSFFDDGRPHAAEWLFDPRRRHLSPLDEVAARLSGLEWEDGSGDEGGDTVTPLLPRRPAMKIVQDPRDVPPPALAPRPAPAPGPRREHLTEPGLAADPRQAPREMTAAAPPAPAAPLAPAPPAPAALERPAAVPPHEPAPAPQPVPAAPRPQAAAPQTAAPQDGEPPADAEAEAEPAAPQTVEAEAAAPQTPPVEEPEAGDTGETGETARPTTETEPEQPAAEPEAPAPEPASATEAEAEPATPQTAEAKPEPEPEQPAASPAAAEPRPPARPAPPKQRPRRDKVPGRPAAPAAGPPVGEPPAAAARDVPVPAPATPAQQRQPAARRRKAKGKRASVPSWDEIMFGARRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Y0G5</accession>
    <name>A0A1H5Y0G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_103493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000003">
        <property type="protein sequence ID" value="SEG17352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG17352">
        <property type="protein sequence ID" value="SEG17352"/>
        <property type="gene ID" value="SAMN04489712_103493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG17352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="402" mass="42908" checksum="556B871EB2A61C6A" modified="2017-01-18" version="1">MGSEAQPEAHYEGVMTGLLVSPASPHWTVVHSAVRVCRRPLPVGRLRGMNSPTTRTERPTLKIQSPHDAVSAVPYLLGFHPADSLVAIGFDGPGATCALRLDLPRPGTADLPHGLAEHVSDLLARNGFRQALLLGYGAPERVTPLIDASRQVLAARGITVREALRVADGRWWSYLCQEPACCPPEGTAYDISSSVVAAEATLAGHVAYADRAELQRTVAPLTGPARQAMREATDRAEARFLLWAAGGLQPAQIRERMVEEAVPLIAGLTARAAGADPPSDDEIAWLGVLLTDLRVRDEAWVRMNADDPAADIAFWRDVLRRVEDPYAAAPACLLAYAAYTNGDGGLANVALDRALATDPAYSLAGILREVIDAGIPPSKARLSLTPEELAAAYAEQDQNPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5Z9K3</accession>
    <name>A0A1H5Z9K3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="13" type="ORF">SAMN04489712_104445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33209">
        <property type="protein sequence ID" value="SEG33209"/>
        <property type="gene ID" value="SAMN04489712_104445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="158"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="258"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="374"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG33209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="445" mass="45864" checksum="1DF435162ED38CEF" modified="2017-01-18" version="1">MGRLFGTDGVRGVAGRDLTARLAMDLSVAAARVLGEAGAFEGHRPVAVVGRDPRASGEFLEAAVVAGLAEAGVDVLRLGVLPTPAVAYLTHTLDADLGVMLSASHNPAPDNGIKFFDRSGYKLADEIEDSIEAHLGEDWDPPTGAGVGRVRDAYGAVEQYVAHLLSTLPVSLDGLRVVVDCAHGAASSVAPEALRRAGAEVVTIGAAPDGLNINAGCGSTHLEALQAEVVRQGADAGIAHDGDADRCLAVTAAGEVVDGDQIMAILATELREAGRLAKDTVVATVMSNLGFKLAMRETGIGMVETAVGDRYVLEAMREGGYTFGGEQSGHVIMLDHATTGDGVLTGLHLLAAMARRGHPLDELAKVMNRLPQVLINVRGVDKSKAASSPELAAAIAEAETELGDGGRVLIRPSGTEPMVRVMVEAGTHDRAQAVAERLAAVVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H5ZCV7</accession>
    <name>A0A1H5ZCV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">SAMN04489712_104474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000004">
        <property type="protein sequence ID" value="SEG33890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG33890">
        <property type="protein sequence ID" value="SEG33890"/>
        <property type="gene ID" value="SAMN04489712_104474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG33890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="102" mass="10997" checksum="841F6007219A2471" modified="2017-01-18" version="1">MTTATKVALKPLEDRIVVQPLEAETTTASGLVIPDTAKEKPQEGTVLAVGPGRVDDKGNRVPLDVKVGDVVLYSKYGGTEVKYNNEEYLVLSARDVLAIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6A756</accession>
    <name>A0A1H6A756_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_105258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG44568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG44568">
        <property type="protein sequence ID" value="SEG44568"/>
        <property type="gene ID" value="SAMN04489712_105258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG44568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="171" mass="18804" checksum="7231424EBE00D7F9" modified="2017-01-18" version="1">MTAIKLDSKLGRSATDALEPHVLPLYGRLGARIVAVLEFEAIERNQVAEDADKDAWVKLRITGMEIPTREQENALREAMRVLYLQRTAFGTLEEDGSIELSEDTLKHAAGVLADIEAAKLRAGVAHWAGRVRRTTGAAKDFTVAELLAEMRQIRDGLDALLDRGQLALEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AHG7</accession>
    <name>A0A1H6AHG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_105462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000005">
        <property type="protein sequence ID" value="SEG48203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG48203">
        <property type="protein sequence ID" value="SEG48203"/>
        <property type="gene ID" value="SAMN04489712_105462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG48203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="231" mass="24592" checksum="CEBC9047D77D2B5E" modified="2017-01-18" version="1">MILELKDVHAGYGSLSVIRGVSLTVEPGQIVTILGPNGAGKTTLLKSLSGLIRPTGGSVILSGTDITRLPAHRRARQGLLHVPEGRGIFDDLTVEDNLRLGGQRLDRSTQDRRADEMYEMFPVLSERRRSRAGLLSGGQQQILAVARGLMSRPKLLMIDEPTMGLAPIMVSEIIASLQGVLDSGTSILLAEQNAAVATRVATTVQVLSNGELSEHSADTGDADAIFDAYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AWQ7</accession>
    <name>A0A1H6AWQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG52764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG52764">
        <property type="protein sequence ID" value="SEG52764"/>
        <property type="gene ID" value="SAMN04489712_10652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG52764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="94" mass="10070" checksum="E00526266E498B26" modified="2017-01-18" version="1">MVRGVLRARGGRVIGEEYLWQVGENAWVVVDDRAERAGGAMITLGVTDLDDILARLAVHGIGHEPVETYGNGVRHVVVRDPDGNSLSLAQAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYD6</accession>
    <name>A0A1H6AYD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53354">
        <property type="protein sequence ID" value="SEG53354"/>
        <property type="gene ID" value="SAMN04489712_10688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG53354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="140" mass="15544" checksum="325144A7AD2F6E90" modified="2017-01-18" version="1">MRYEITADIDAPAERVWEVLVDVERWPEWTASMDEVRRLEDRPFGTGATVRIKQPKLPTAVWEVTDFVPGSSFTWVSKSSGITSTAVHELTSAPGGPVTVRLVFDQSGPLAPLLGVFAGRLVRRYLTLEAEGLKRRSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6AYP6</accession>
    <name>A0A1H6AYP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cholesterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_106112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG53728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG53728">
        <property type="protein sequence ID" value="SEG53728"/>
        <property type="gene ID" value="SAMN04489712_106112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="2">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG53728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="543" mass="57878" checksum="889F4CBD0DE0BD84" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6B5H8</accession>
    <name>A0A1H6B5H8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_106247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000006">
        <property type="protein sequence ID" value="SEG55645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG55645">
        <property type="protein sequence ID" value="SEG55645"/>
        <property type="gene ID" value="SAMN04489712_106247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG55645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="204" mass="23016" checksum="C9E1503E1224C02C" modified="2017-01-18" version="1">MNEAQVTVIGWLAQDPFFTMTANGTPFLALRVGCTPRRYDRQSGQWQDLEPMFLTVNCWRSLAENVNASDMKRGEPVVVSGRLRIREYVKDGRLRFSAEIEATTVGHDLSRGSAQFRRVQRGTMTEEDRREARELTDQWSLAESPTDGETTRDSATDTENPQATEPTDTLRNEDADLFGEPADPRATATDTDDHDLFELRTQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BGE3</accession>
    <name>A0A1H6BGE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_10793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG59829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG59829">
        <property type="protein sequence ID" value="SEG59829"/>
        <property type="gene ID" value="SAMN04489712_10793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009293677" evidence="1">
        <location>
            <begin position="25"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG59829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="214" mass="22253" checksum="885F083B851B2363" modified="2017-01-18" version="1">MRRKIVTGAVALTMLVGFGGAASAAPERKPKPPKPTEVKVALPEGQSNPSIANGVGVGSLVTTYTSSGLGPAGTNTSAPAGTPERYVDFPGGALPPGVTLTEAQSINALRQISANLQAAGLTPRDVISMRAYLSNPPGSDTADFAGWNRAYRQFYANTDLVTGKVVNVPLGTAAPAPPLYVNPARPARVTLEIENLPVQGWLVEVEVVAAYRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BN78</accession>
    <name>A0A1H6BN78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_107255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61905">
        <property type="protein sequence ID" value="SEG61905"/>
        <property type="gene ID" value="SAMN04489712_107255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG61905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="128" mass="14061" checksum="126E59468BCFD67A" modified="2017-01-18" version="1">MQSWTDPPGERWIDEAAGPLVRPYALTGGRARPRGEPLDIVAILIGSGRPVPGHVRLTREQQRLLALCRRPYTVADLASELDLPLGVVVVLVDELLEQGLIEVARPAAPAARPDPRLLRRVIDELRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNC6</accession>
    <name>A0A1H6BNC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG61955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG61955">
        <property type="protein sequence ID" value="SEG61955"/>
        <property type="gene ID" value="SAMN04489712_107260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG61955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="405" mass="43107" checksum="7E2437671420E312" modified="2017-01-18" version="1">MTDQPPDDDRTREIAIPERVSPDALDQTRQDEPAGAAATAPQPLPAEPERASRPERASQDERASRPEQASEAQPGPPPPGPAKATAPQVVPPEPPASPPAPQPTLQQPLPQQSAPQQPQPQPQPVQVTPPPPPQPMQAPSVPPPLPDLPGQQPRRVTFHRFHYPIGIFMVAYGVSTLLLSVLGWSAHRMEMAGYLGEGAASPALIAVKVVEGLLVLLALVGLVRRRDVWFLPALFGWVLGFAVFCVLAGVEGKMMDLVEHGAYLVVFTFLLCLSYALGVKARVAARQAVPPEPGQGSGGSGPDQGSGRLTRTQEIALAALNRWQRQQPAPPQGPHQPGPAPQQPQPPHQQFPPQPGPPQQSQAPHQPQASQQPQAPQQYGPPPQQQGAAPQGPGQFYSEPSPGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BNE3</accession>
    <name>A0A1H6BNE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62228">
        <property type="protein sequence ID" value="SEG62228"/>
        <property type="gene ID" value="SAMN04489712_107282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG62228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="83" mass="8422" checksum="361226913E2C9D6A" modified="2017-01-18" version="1">MVSAASMIGIAVVALQNLILGGTQITVAMIGNTLITLTAGGLAVFLARRPAWTRAQRAFMATVLGGPAVKMATDRSRAVAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPJ8</accession>
    <name>A0A1H6BPJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_107309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62621">
        <property type="protein sequence ID" value="SEG62621"/>
        <property type="gene ID" value="SAMN04489712_107309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG62621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="431" mass="46063" checksum="23F2E437E4DBBBC6" modified="2017-01-18" version="1">MSDLLARHRAVMPDWLALNYDRPIEIVSGKGSRVTDSEGNTYLDFFVGILTNMIGYDVEEVRQAVERQLATGIVHTSTVYLLRGQVELAEKIARLSGIDNAKVFFTNSGTEANETALLLATYARRSDQVLAMRQSYHGRSFGAIGVTSNRSWKNNSYSPLNVHFLHGADRHLPQFARLSDHDYIKVCTEDLRHVLATATGGDVAALIAEPIQGVGGFTMAPDGLFAAYKDVLDEYGALFISDEVQTGWGRTGQSFFGIQSHGVTPDMMTFAKGLGNGFAVGGVVARGDLMDSLHAVGLSTFGGNPISMAAANATLDYVLDHDLQANAARTGSFLIAGLKEAARRLPVVGDVRGKGLMFAVELVDPATGEPAPALAATVMEETRKRGLLAGKGGLYGNVIRMAPPLTLTEAEAKEGLGILTDSLEATNEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BPN2</accession>
    <name>A0A1H6BPN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_107294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000007">
        <property type="protein sequence ID" value="SEG62405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG62405">
        <property type="protein sequence ID" value="SEG62405"/>
        <property type="gene ID" value="SAMN04489712_107294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG62405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="275" mass="29867" checksum="CD4D7A02B7976D1B" modified="2017-01-18" version="1">MPLVTATRYVAPLREGGSLPGIVEADDLGTYVMKFTGAGQGRKALVAEIVAGELARRLGFRVPDLVVIDLDPVIARHEPDPDVQDLLKASTGWNLGVDFLPGSLGYDPLGWTADPAVASRLLWLDAFIGNVDRSWRNPNLLVWHGDMWLIDHGASLYFHHAWANAAKLVLRPYDVDDHVMVPYATRLAEAEQTLLPQVTKELLREITALVPDAWLAGEPGFTDAEAVRDAYVELLTARAAEPRAWLPDLTAGGRRPAPAPRPGAGRPSWLGGPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BU38</accession>
    <name>A0A1H6BU38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_1083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64218">
        <property type="protein sequence ID" value="SEG64218"/>
        <property type="gene ID" value="SAMN04489712_1083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG64218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="385" mass="40257" checksum="8C94B5A3742D941F" modified="2017-01-18" version="1">MPQGPALPEDVTGEELDAEARVELRTLPRDLATKVARHLVMAGRLVDDDPQTAFRHAQAARRLASRVGIVREAAGLAAYHTGEWSEALAELRAARRLRNTEEAYLPILADCERGLGRPERALDLAKSPAARDLDQADRIELKIVESGARRDLGQLDAAVVTLQIPELRDKRLQPWSARLFYAYADALLEAGREEEAGEWFARAAAADRDGETDAAERYAELAGLEIIDVEDDEDQALETDVTVEESPAEAGRAAAGPEEAGTSAQTDVESTTAVEEPDVSDRPEAQDTVGEPSAPGSPGTDEATGTGPADADAPEATGDSGAGTPEASVSEVQGVTDASDAATAEATEVAGEPGPVDASGGEPAERTAPPADEPNTENGVSPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6BWB5</accession>
    <name>A0A1H6BWB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SAMN04489712_10851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG64745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG64745">
        <property type="protein sequence ID" value="SEG64745"/>
        <property type="gene ID" value="SAMN04489712_10851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SEG64745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="349" mass="38376" checksum="C4C8DFB708CAD6E5" modified="2017-01-18" version="1">MSAFWAWTVFGVAVLVSVVVVEGIRRLLAGRLSARWPGAGEAARRVTAPAFAAAVMFSAQASLPAAEHLGGPGVDRVARHLLWIGGVATATWLLLRITYALTDPALDRLTRVEGERNRRARRARTQMLLLRRIAGAVVVIVAVGAVLFSFPAVRVMGAGVLASAGVAGLVVGIAARPVLGNLLAGLQLAFSDALRLDDVVVVDGEWGRIEELTLSYVVVRTWDERRLILPVSYFTEQPFENWTRQGSRVVGAVLFHVDWTVPVDDLRTELYRFLREHPLWDQRDWVLQVTEVLPNGLVQLRALMSAADAASAWDLRCDAREHIVDYLRQEHPRALPRLRTELPIGTGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C0P7</accession>
    <name>A0A1H6C0P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_108201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000008">
        <property type="protein sequence ID" value="SEG66531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG66531">
        <property type="protein sequence ID" value="SEG66531"/>
        <property type="gene ID" value="SAMN04489712_108201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="104"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG66531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="586" mass="63518" checksum="4DA94AAAB99EBCC7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6C8C6</accession>
    <name>A0A1H6C8C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SAMN04489712_10963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG69229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG69229">
        <property type="protein sequence ID" value="SEG69229"/>
        <property type="gene ID" value="SAMN04489712_10963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SEG69229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="129" mass="14181" checksum="0788E6D2EA707A3B" modified="2017-01-18" version="1">MDPAGPGPAREEDQLNRCTVTSGFFVLGHCGRTAVAPCAQCGRPTCQEHYGPDGLCAECRAAASPTRSPYDEQWVRGYRRGYYSRSSQTYGDATWYSGFDEYDRGAFNPGQGHYLGDYDHDGDDGFVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CEF9</accession>
    <name>A0A1H6CEF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_109262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000009">
        <property type="protein sequence ID" value="SEG71344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG71344">
        <property type="protein sequence ID" value="SEG71344"/>
        <property type="gene ID" value="SAMN04489712_109262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG71344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="37" mass="3659" checksum="0ABCAFF2886F7619" modified="2017-01-18" version="1">MSGGKAPMSGAKGFAVVIGGMFAIILVLWVLAALLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CJX7</accession>
    <name>A0A1H6CJX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Valine dehydrogenase (NAD+)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SAMN04489712_11093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 43163</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73291">
        <property type="protein sequence ID" value="SEG73291"/>
        <property type="gene ID" value="SAMN04489712_11093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="6">
        <location>
            <begin position="148"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="184"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SEG73291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="362" mass="38370" checksum="3365483C2C477857" modified="2017-01-18" version="1">MTNVFGSPHKGSGPSHEQVVFCQDEASGLRAIIAIYSTALGPSLGGTRFYPYGSEDEALTDVLNLSRAMAYKNALAGLDLGGGKAVIIGDPELDKSEALLRAYGRFVQSLNGRYYTACDVGTYSEDMDVIARESTYVTGRTVAHGGAGDSSVLTAYGVFQGMRAAAQALWGSPTLRGRRVGIEGVGKVGHRLVEHLREDGAEVVICDVSEAAVDRVRRLHPEVEVVADGDALVKTDLDVYSPCALGGSLNDETVPLLRARIVCGGANNQLAHPGVEKRLADRGILYAPDYVVNAGGVIQVADEIEGFSFERAKAKATQIFDTTARIFALAAEEGVPPAVAADRLAERRMTAVGRLRGIFLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CL16</accession>
    <name>A0A1H6CL16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome d ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SAMN04489712_110143</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 43163</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73699">
        <property type="protein sequence ID" value="SEG73699"/>
        <property type="gene ID" value="SAMN04489712_110143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SEG73699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="463" mass="50951" checksum="662B98C8075C6208" modified="2017-01-18" version="1">MNALDLARWQFGITTVYHFVFVPLSIGLTALVAVMQTMWRIRRDDRYLRLTRFFGKLMLINFAIGVVTGIVQEFQFGMNWSDYSRFVGDVFGAPLAMEGLLAFFLESTFLGLWIFGWDRLRPSLHLACIWLLALGTTLSAYFILAANSWMQHPVGYRINPDTDRAELTSIWKVLTNVTTLVTFPHVLFGALITAGMFVAGISAWYVAGRRDTEVFRPALRLGLAVTLLASAGVMVSGDLQARVMTEQQPMKMAAAEALYETSAPASFSIFTIGSLDGRAELWSLRVPHVLSFMATGSPDGTVEGINDVQRAYEAQYGPGSYIPVVPITYWSFRLMIGFGVLAGLVAVWGLWLTRGGRSPQGRWFRRAALAAIATPFLANTMGWIFTEMGRQPWVVHGVLQTRDGVSPTVGSGSVVISLTVFTLLYGVLAVVAGALMVRYARQGPPPAAQQTAEADEPVPSFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CLD7</accession>
    <name>A0A1H6CLD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase small domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SAMN04489712_11086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG73236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG73236">
        <property type="protein sequence ID" value="SEG73236"/>
        <property type="gene ID" value="SAMN04489712_11086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="149"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SEG73236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="484" mass="51421" checksum="B3F60FA4E951B182" modified="2017-01-18" version="1">MGERGDAPGRVRSFFERAGYTVAGVRELLGPVAGGALARDEIVPALRAASGGSPLEAAVRLCWLQVPVPESAIPEADALVALGLAERAGGELRPLLHVEPLEGTDGGHLGHVVSDLKVRPGDGSALRPDHVVGSGGASAGLAQLAIHSPVDNALDLGTGCGVQVLHLRGRAARLTATDLNPRALRLARMSFALSGLDGVELLEGSLYEPVRDRRFDLIVANPPFVISPGGGLVYRESGLPGDDVCRRLVTGAADRLNAGGWCQLLANWLHIDGMPWQERVAGWVPAGCDAWVVQRDVQDPAEYAELWLRDSCEVGTPEYAARYEAWLDYFERQRVTGVGFGWITLRNSGADHPVVRVEEIRHAVEQPVGAYVARILDGLTAGPRFSTGCPQGLRTAEGVVQEQIGPPGAEDPERIVLRQRDGLRRAAGVGTVEAALAGVCDGSFPLPPLLDAIAELMDLPREQVHAHADAVLPELIADGFFEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1H6CMB3</accession>
    <name>A0A1H6CMB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SAMN04489712_110187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermomonospora echinospora</name>
        <dbReference type="NCBI Taxonomy" id="1992"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptosporangiales</taxon>
            <taxon>Thermomonosporaceae</taxon>
            <taxon>Thermomonospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Varghese N."/>
                <person name="Submissions S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 43163</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="FNVO01000010">
        <property type="protein sequence ID" value="SEG74080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SEG74080">
        <property type="protein sequence ID" value="SEG74080"/>
        <property type="gene ID" value="SAMN04489712_110187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000236723">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="838"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SEG74080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000236723"/>
        </source>
    </evidence>
    <sequence length="905" mass="96246" checksum="13D1C95BBB3D5883" modified="2017-01-18" v